Gene PTPN1
PTPN1
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of PTPN1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | PTPN1.AA | Subfamily.N_Nematode_egg.PD | 2-235 | 25 | 6.4e-24 | 76.3 | In-house | 1-214 (257) | Show / Hide |
Range on Protein: 2-235
Range on HMM: 1-214/257
Sequence Identity: 25% (59 aa)
EMEKEFEQIDKSGswaaiyqdirheaSDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQE----DNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWE
|.|..||....| . . . | .... | . | . ||.||. . .|.| | .| ..||.| || || || ||...
elerrfeilersv-------------deislttaasdnylekarskrvhckessrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvedfwr
MVWEQKSRGVVMLNRVMEKgsLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIK--SYYTVRQLELenLTTQetREILHFHYTTWpDFGVPESPASFLNFL
| . .|||. .| .| |||. |.. . . .|... . | | ..| .|| . .. .| |. . . |. | |. | |.|.
mvfqekvqyivmltsakes--erceyywpkaeseslvtvpGslrienlkvdskadplfrvtklkl--vGgd--deelflehwqg-dvnylsdvysplrvl
FKVRESGSlspehgPVVVHCSAGIGRSGTFCLADTCLLLM
||||.. |. ...|. ... || .
rklrnlsk------pvvvqdilGvskaatlvaieiallsl
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| Phosphatase | PTPN1.AA | Subfamily.N1.PD | 16-279 | 67 | 4e-144 | 470.5 | In-house | 2-268 (268) | Show / Hide |
Range on Protein: 16-279 Range on HMM: 2-268/268 Sequence Identity: 67% (180 aa) WAAIYQDIRHEASDF--PCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRV ...|...|..|.... ..|.||||.|...||||||||.|||||||...|.|||||||...|||.|.|||||||||.|..|||.|||||.|..|.|||.| ykeilleidkeskekeletreaklpenrglnryrdvspydhsrikleradvdyinaslveleeakrrYiLtqGPLphtadHFWqmvWeqnskavimLnkv MEKGSLKCAQYWPQKEEK-EMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVV .||...||||||||.||. |...|.|.||..||||..|||..||.||||.|.|||||||||||||||||||||||||.||.||||||||||||...||.| vEknqikCaqywpqeeeeaellleetklkvkliseerksyflvrlleLedletqetreilhfhyttwpdfgvpespaafLkfLfkvresgsLssdvgpav VHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAK .|||||||||||..| ||||....|..| ..|||||||||.||.|.|||||.|||||||.|..|||| ihCsagigrsgtlslvdtclveiektgdlnavdikkvLlelRkyRvGLiqtpdqLrFsyiailegak |
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| Phosphatase | PTPN1.AA | PTPc | 15-279 | 35 | 6.1e-128 | 432.25 | SMART | 1-308 (308) | Show / Hide |
Range on Protein: 15-279 Range on HMM: 1-308/308 Sequence Identity: 35% (113 aa) SWAAIYQDIRHEASDF---------PCRVAKLPKNK--NRNRYR-DVSPFDHSRIKLHQ--------EDNDYINASLIKMEEAQRSYILTQGPLPNTCGH . ........ . .. .|..|..|.|. ..|||. |. ..||.|.||.. |..|||||. |.... ...||.||||||.|. . GFWEEFERLQRMTPWDLMSNYDPCCSCTCACWPENREMDKNRYKCDIPCYDHTRVKLKPPPGESHCYEGSDYINANYIDGYWRPKRYICTQGPLPHTIED FWEMVWEQKSRGVVMLNRVMEK--------GSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKS-YYTVRQLELENLTT--------QETREILHFHYT || |||.||.. .|||.. ||| | ||.||||.. .| .. ....|..||.... .||.|..|..| .. .|||.. |.||| FWRMVWQQKCHIIVMLCNCMEKCTENRDQNGREKCHQYWPDE---PMTYG--HITVTCKSEEKCPDDYTMRTFEVTNTGCNCKYSMACSETRTVTHYHYT TWPDFGVPESPASFLNFLFKVRESGSLSPE-----------------HGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGL .|||.|||||| |||.|. .||.. | ||. .||.|||||||.||.||||..|... .... |||.... .||. |.|. NWPDHGVPESPDSFLDFIRQVRHWQSHSPNMYMNMVSSNSKYHHTCPTGPIVVHCSAGCGRTGTFCAIDIMCQQIEN------VDIFQIVKMMRNQRPGM IQTADQLRFSYLAVIEGAK .||..|..| | ...| .| VQTEEQYIFCYRCILEYIK |
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| Phosphatase | PTPN1.AA | Y_phosphatase | 40-276 | 44 | 1.5e-116 | 398.31 | Pfam | 1-243 (243) | Show / Hide |
Range on Protein: 40-276 Range on HMM: 1-243/243 Sequence Identity: 44% (111 aa) NKNRNRYRDVSPFDHSRIKLH----QEDNDYINASLIKM-EEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGS-LK-CAQYWPQ-KEEK ||..|||.|. ..||.|.||. || |||||. |.. .. ||.||||.|.|...|| |||.||.. .|||...||.| | |.||||. ||. NKEKNRYKDIPCYDHTRVKLQPIPGDEDSDYINANYIDGPYWNPKAYICTQGPMPHTIEDFWRMVWQQKCTCIVMLCNCMEMGRDEKTCHQYWPDNKEGQ EMIFEDTNLKLTLISEDIKSYYTVRQLELENLTT--QETREILHFHYTTWPDFGVPES-PASFLNFLFKVRESGSLSPEHG--PVVVHCSAGIGRSGTFC .| . ... |..||. ...||||..|..| .. ||||.. |.|||.|||.||||| | |.|.|. .||.. . .|.|| |.|||||||.||.|||| PMTYG--DFQVTCVSEEHCPDYTVRTFEVTN-GDQKQETRTVTHYHYTNWPDHGVPESQPKSMLDFIRQVRKWQP-NPDHGCPPIVVHCSAGCGRTGTFC LADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE ..|... .|.. ... ||.... .||. |.|..||..|..| | ...| AIDIMCQQMEHEGTV---DIFQIVKHMRNQRPGMVQTEEQYIFCYQCILE |
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| Phosphatase | PTPN1.AA | Subfamily.N3.PD | 19-275 | 40 | 2.4e-78 | 254.5 | In-house | 5-257 (261) | Show / Hide |
Range on Protein: 19-275 Range on HMM: 5-257/261 Sequence Identity: 40% (103 aa) IYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQ----RSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVM .. . .. .. . .|..|.| ..|||||..|.|. |.||.....|||||. ..|| || |||||..|. .||.|||||||. .||| ..| qfeelyrkkpglaisaarkpenlaknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGplaktakdfWqmvweqkstlivmlttlv EKGSLKCAQYWPQKEEkEMIFEdtNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGslSPEHGPVVVH .| || ||||..|. |. | ...... .|| .. | .|.| |.. .|.| |.||.. |. ||| |||...|.||.|. .||.| .. |||||||||| erGrvkChqyWPeted-elefg--efsvrcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr--sgkeePvvvh CSAGIGRSGTFCLADTCLLLMDKRKDpssVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVI ||.| . | .|.| |...... | . ... .|| |. |.||..| .| |.. CsaGigrtGvlilletalalieaaep---vypldivrtmrdqramlvqtvsqykfvCeail |
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| Phosphatase | PTPN1.AA | Subfamily.RB.PD | 19-275 | 38 | 1.2e-77 | 252.4 | In-house | 5-257 (261) | Show / Hide |
Range on Protein: 19-275 Range on HMM: 5-257/261 Sequence Identity: 38% (99 aa) IYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKL----HQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVM |..... .| ... |....|...||.. . |.||||.|| ...|.|||||. |. . .| || ||||||.| .||.||||.||. .||| ...| eyeelkkvgkdqavkaaeeavnraknrftnilpydhsrvkLaalkdesdtdyinanyipgynspreyiatqGPlpetvddfWrmvwekkssiivmltqlv EKGSLKCAQYWPQKEEKeMIFedTNLKLTLISEDIKSYYTVRQLELENltTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVH || || .|||..||. ... ..|.||..|. .. ...|....|. .|.|.. ..|.|.|||.||||.... |.|. .|||.. .....|.||||| EkgkekceeYWPadeep-vly--Gdikvtllaekeldewvirefkiek--gkekrkvrqyhftsWpdhgvPektktlldfvrtvreaiekkaskkPivvH CSAGIGRSGTFCLADTcllLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVI ||.||.||| |. |... .. ||. |. |.|. |. |.|| .| | . ... CsaGvGRtGtfialdr---llqaieendyvdvfgvvaelReeRnllvqtekqyifihecll |
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| Phosphatase | PTPN1.AA | Subfamily.N13.PD | 20-276 | 41 | 4.7e-75 | 244.0 | In-house | 6-256 (259) | Show / Hide |
Range on Protein: 20-276 Range on HMM: 6-256/259 Sequence Identity: 41% (104 aa) YQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNdYINASLIKM--EEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKG ....|. . |.|.| .||..||||.| |.|..|.|| .| . ||||||||. .| . .||..|||||.|. || ||||||.. ..|.||| .|| fkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg-yinaslikvpvgedeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekg SLKCAQYWPQKEEKEMIFEDtNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVREsgsLSPEHGPVVVHCSA .|||....|.. .. |...|. .. ..||.|..... ..|.||. |.....||| ||| |.|....|. .||.| ..||.||||||||||||. kvkchrywPerknkklkvsn-rlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaelvqfvaevrl---lqtdagPivvhcsa GIGRSGTFCLADTCLLLMDKRKdpsSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE . |. | |... | ..|.|... ..|. | |..|| || | | |..| GiGrsGvlitidvvlglierdk---efdvkeivrklreqrqgvvqtkdqyifvykaile |
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| Phosphatase | PTPN1.AA | Subfamily.N9.PD | 20-278 | 41 | 6.7e-75 | 243.6 | In-house | 6-274 (275) | Show / Hide |
Range on Protein: 20-278 Range on HMM: 6-274/275 Sequence Identity: 41% (114 aa) YQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQED----NDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVME |.|||.|. ..||. | ..||| || .|..|.|| ..| |||||. .. . ....|.|||||..|. || |||||. . .||||.|.| yadirnepveGtflasklranleknrytdvlcydetrvklakldedeasdyinanfvdGykqkkafiatqGplkktvsdfwrmvweqevlvivmttrvve KGSLKCAQYWPQKEEKEMIFEDtnLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLS---------- |||.||||..||. . | | |... .. . .. |.||.||..| .|.|.|.. || ...|||.|||.| ||.|..| |||| .|. . rgrlkcgqywpleeessaefgd--lsvsnveveveedykvrvleiknvkteesrkvthfqflswPdyGvPssaaslldvlekvrekqalavkelgdeskg -PEHGPVVVHCSAGIGRSGTFCLADTCLllmDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGA . |.||||||||||.|||. | || .. .. . ||..... .|. | ||| .| | ||||.| | hlsgPPivvhcsaGiGrtGtfitldicl---arleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya |
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| Phosphatase | PTPN1.AA | Subfamily.N12.PD | 26-276 | 39 | 1.7e-73 | 238.6 | In-house | 18-267 (270) | Show / Hide |
Range on Protein: 26-276 Range on HMM: 18-267/270 Sequence Identity: 39% (101 aa) EASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKC . . .. ... ..|...|||.|. |.|.||..|.. |..|||||..|| | . .|| .|||||.| || |.||.. . |||. |..| | || aekvysteagekeenvkknrykDilPydksrvelskieeeegsdyinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkC AQYWPQKEEKEMIFEDtnLKLTLISEDIKS-YYTVRQLELENLttQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSlsPEHGPVVVHCSAGIG ..|||.. |.|. |.. ...||..|. . ...|.|..|. .|.|.. |||| ||| |||.|. | |... .||| .|. |.|||||||.|| | eryWpeegeeelefge--fevtleeekavdddflirtLkveaq--kesrkvyqfhytaWPDhgvPssaksllelielvrelqe--sedaPlvvhCsaGvG RSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE | . | |. ..| |...|. ...||.|| | |.|| .| .. | ||.| rtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae |
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| Phosphatase | PTPN1.AA | Subfamily.R_Anemone_1.PD | 17-276 | 38 | 4.5e-73 | 237.6 | In-house | 3-255 (258) | Show / Hide |
Range on Protein: 17-276 Range on HMM: 3-255/258 Sequence Identity: 38% (99 aa) AAIYQDIRhEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNR || .| .. |. .. ||. ..||..||| |. ..||||. |.. |. |||||| .. . .|..|.||.||..|.. |||||..|. .|||. . aaefqrlk-eikeeekevarkaenkkknryadivaldhsRvvLeklsndeesdYinasylrasdktrafiatqapleetvedFWrmvwqekigviVmLtn VMEKGSLKCAQYWPQKEEKemiFedTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESgsLSPEHGPVV .|. || ||||...|| . ..|...| ... .. |..|.| |.. ...|.||. ..|.|.||||||. .. |... ||..| ... ||||| liegekkkchqYwPdstek---y--gelrvslrkkevfadyiirtlvlskkketeerevvqyhftvWpdkgvPqyatavLglrrkvqks--slagarpvv VHCSAGIGRSGTFCLADTCLllmDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE ||||.||.|.|. |. | .. | ||| ... .|. | ..|| .|| .|||.| vhCsaGvgRtGaflvidaml---eqakkekvvDifnyvkairedrphmvqtkeqyvfihlavle |
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| Phosphatase | PTPN1.AA | Subfamily.N6.PD | 27-274 | 38 | 4.4e-72 | 234.4 | In-house | 27-290 (295) | Show / Hide |
Range on Protein: 27-274 Range on HMM: 27-290/295 Sequence Identity: 38% (101 aa) ASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQE-----DNDYINASLIK-------------MEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVV . . .. .. ..||. |||... ||||.|..|.. ..|||||. |. || |..|| |||.|..| ||.|||...|| .|| eklysrkegekienkeknryknilPfDhtrvilkdgepsvpgsdYiNanyirlpkaskssgenveseehqkryiatqgcLkdtvsdFWrmvwqensrviv MLNRVMEKGSLKCAQYWPQKEEKEMifeDTNLKLTLISEDIKSYYTVRQLELENL-TTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPE . . .|.| |||.|||..|.|. ....| |||. .. ||.|...... . .|.||| ..|...||| |||..| .||||.|.. . ..| mttkevergknkCarYWPdeetkke---tGvitvtsisEkstadYtlRefsvshkdkdkeareifqyhfkaWPdhgvpkdpgvvlnfledvnkkqeelek HGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAV |.|||||||||| ||| . |. | .. ... .||.|.. ..|..| ||.||..|..| | || agpivvhcsaGiGrtGtfividivlkiieqsgldvdidisksikdvrsqrsglvqteaqykfvykav |
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| Phosphatase | PTPN1.AA | Subfamily.N_Choan_1.PD | 16-276 | 33 | 7.4e-71 | 230.1 | In-house | 2-259 (262) | Show / Hide |
Range on Protein: 16-276 Range on HMM: 2-259/262 Sequence Identity: 33% (90 aa) WAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKL----HQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLN .. |..... | ... .| ..|...|||.... .|..|.|. .....|||||. .. . .. || ||||.|... .||.|||||| . .||. fieeyeklaeigvdntataskadenvlknrysnivayDatrvkvtpneenkntDyinanfvpgykgekeyiatqgPvPaslvsfWqmvweqkvsaivmvt RVMEKGSLKCAQYWPqKEEKEMIFedTNLKLTLISEDIKSYYTVRQLELeNLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEhGPV | .|.| ||| .||| |..|. . ...... .|| |. | |...| . .. ||||. ...||.||| |||.... .|.| .|.. . . . |. reieagklkChryWP-denselkl--gdvtvkslseeekktyierkfkl-eresgetreveqlaytaWPdhGvPattkellefrkavlkatkkktk-apl VVHCSAGIGRSGTFCLADTCLLLMDKRKDpsSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE |.|||||.||.||. |. . ...... .|.| |. |.|| |. ..|| | .| |.|| . vihCsaGvGrtGtyialDrlvkaveekae--aldvkavvaelrkernlmvqtlvqyefvykavld |
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| Phosphatase | PTPN1.AA | Subfamily.R_Anemone_2.PD | 20-276 | 37 | 1.1e-70 | 229.7 | In-house | 6-259 (262) | Show / Hide |
Range on Protein: 20-276 Range on HMM: 6-259/262 Sequence Identity: 37% (98 aa) YQDI-RHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVM |. . |.|.. . .. | | ||..||| .. ..|..|.||.. |. |||||. | .....|| ||.|||.|. || |||||.|. .||| ... yerlsrseetsvtlksalepvnkaknryanilaydktrvklqmlegeegsdyinanyidGyrrkkayiatqaPlpetiedfWrmvWeqnsavivmltqee EKGSLKCAQYWPQKEEKEMifedTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESgSLSPEHGPVVVH |.| |...|||.|. ... .|. .| .| |.|..|...... ..|.|.. ||||.||| |||||.||.|... .|.. ....||.||| ergkakvhryWPskgsrsy----gklvvelkeevelsdyvlrsfkvkrteeeeerqvrqfhytsWpdegvpesgaslldlvrqveka-qqesgagpivvh CSAGIGRSGTFCLADTcllLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE ||||.|| |.|. |. |... |. . ||. ... ..|. | ..|| || || ...| csaGvGrtGvfiavdi---llerikaealvdvfqtvkqlreqrnlmvqtkdqyefiydvlle |
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| Phosphatase | PTPN1.AA | Subfamily.R_Sponge_2.PD | 19-275 | 34 | 2.1e-68 | 222.2 | In-house | 5-258 (262) | Show / Hide |
Range on Protein: 19-275 Range on HMM: 5-258/262 Sequence Identity: 34% (89 aa) IYQDIRHEaSDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQ---EDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVME .......| ..| . |||..|. .||.... |.|.||..|.. .| |||||| . . . .|| |||||..| . || ||||.|.. .||| . | eeksveke-tefslsiaklkenvgKnRfkeilpydmsRvrLrtdgskdsDYinAsfvdgykrrkayiatqgPlketveDfWRmvweykvstivmltnlee KGSLKCAQYWPQKEEKEMIFEDTnlKLTLISEDIKSYYTVRQLELENLTT-QETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSpEHGPVVVH .| |||.|||.|...|. . .. | || .| . |..|.|.| . .. ...... .||...||. .||.. .|.|... .|... | . ....|. ngkekcakYWPekvdeeveygkf--kvtlkeeekladyiirklklskekssegeadvtqfhfvaWpehevPkdatsllelikrvlraqkks-gnkaitvv CSAGIGRSGTFCLADTClllMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVI ||.|.||.|||. |. ... | ...|. .|| ..| |.||.|.|.| | .|. CsdgvgrtGtfialdsv---lerlkaeeeidvfevlktlrtkriglvqdaaqYvfihdall |
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| Phosphatase | PTPN1.AA | Subfamily.RG.PD | 20-275 | 37 | 7.9e-66 | 213.7 | In-house | 6-260 (264) | Show / Hide |
Range on Protein: 20-275 Range on HMM: 6-260/264 Sequence Identity: 37% (98 aa) YQDIRH-EASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVM ...| . ...|... .| ..||..||. .. ....||.||.. ...|||||| |. . .. || |||||..|. || |.||.... .||| . feeiqklkpkdieaesskkeenkeknReinivaversRvklsplpgkdgkDYinAsyidGyrrskeyivtqgplketiedFWrmiWehnaqiivmltdld EKGSLKCAQYWPQKEEKEmifEDTNLKLTLISEDIKSYYTVRQLELENLTTQETRE--ILHFHYTTWPDFGVPESPASFLNFLFKvrESGSLSPEHGPVV ||| ....|||.|.| . | .||.||.|.. .|.||||.. |.| ... .| . ..|||.||| |.||| . .|.| | |. . . | ||.| ekgrrdedvyWPkkdepl---elealkvtllskeklskytvrdfvlkntkddkekervvrqyhytkWPdmgsPestlfvlifvkk--eeaankeeaGPiv VHCSAGIGRSGTFCLADTCLLLMdkrKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVI ||.||| ||.||.. || | . .. ..|.. .|| .|. | ||..| .| .| | |.. vhdsaGvgragtyialdtllqql---ekeeavnvyqvlklirakRpglvtteEqyvfiydall |
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| Phosphatase | PTPN1.AA | Subfamily.N14.PD | 20-276 | 39 | 3.3e-65 | 211.5 | In-house | 6-272 (275) | Show / Hide |
Range on Protein: 20-276 Range on HMM: 6-272/275 Sequence Identity: 39% (106 aa) YQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH---QEDNDYINASLIKME--EAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVM |. | .. | . .||||.|...||..|| |....|..| .....||||| ||. ..|||| .||||..|. ||.|||||. . .||| . yeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfwqmvweqgvqlivmlteee EKGSLKCAQYWPQKEEKEMIFEDTNLKLTL-ISEDIKSyYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVR---E-SGS-LS--- |.| |. .|.|..|.|. | . |.| ||| .| .. ..|.|. | ..| |...|. || ||| |||| . .||.|| .|.. . | . .. edgkeksfkylPkleskkktvefgkfkvttkfsedsds-vittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsfLeevqsvrrktnsevesvk PEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKdpsSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE ||.||||||.||.| |.| . ... . ..|||||| .|| || |.|| | .| | ..|. eskPPvlvhCsaGvGrtGvlilsdlliatlehne---eidikkvlarLrkqrmllvqtlaqykfvykvlik |
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| Phosphatase | PTPN1.AA | Subfamily.RK.PD | 29-276 | 31 | 3.1e-63 | 205.0 | In-house | 18-264 (267) | Show / Hide |
Range on Protein: 29-276 Range on HMM: 18-264/267 Sequence Identity: 31% (80 aa) DFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQ---EDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRV-MEKGSLKCAQY | .||...|...||. |. ..|.|...|.. ...|||||.|| . . .| |||||..| || .|..... .|||. . .|.|.|| .|||.. sedcdiakkdrnreknrsmdilaydrslvflisvdgdssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmlteldvevgrvkClky WPQKEEKemIFedTNLKLTLISEDIKSYYTVRQLELEN--LTTQETREILHFHYTTWPDF-GVPESPASFLNFLFKVRESGSLsPEHGPVVVHCSAGIGR |. . ..|..|.. .... . || . .|. . .|.||. .|....||.. .||.| |.|... .| .| . |.|..||||.|| |||||| WPedtev--ry--gdikvelveaeldadlvvrifrveklargqeeirevrqfqflgWpeyrdvPvskrsllklirrvkksqee-eeeGrivvhClaGaGr SGTFCLADTCLLLMdkrKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE . |. | .. . . ||. .. ..|. .. ...| .| .| | ...| sGtfiaidivlemi---eregvvdvfnavktlrnrkvnmveteeqykfvydvile |
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| Phosphatase | PTPN1.AA | Subfamily.N_Choan_2.PD | 34-276 | 35 | 4.5e-63 | 204.4 | In-house | 15-263 (266) | Show / Hide |
Range on Protein: 34-276 Range on HMM: 15-263/266 Sequence Identity: 35% (90 aa) VAKLPKNKNRNRYRDVSPFDHSRIKLHQEDND----YINASLIK-MEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQK . . .||. |||.|. | ..|..|.....| |||| .. .......|| ..||||.| .|| |.||.|.. .||. ..||| ||..|||.. iPeyarnkrlnRyndiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpae EEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENltTQETREILHFHYTTWPDFGVPESPA------SFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRS .... ..| ..| . .|| .. | ...|.||. .|||.. ||.|.|||| |||... . |. |.||.. . . .|..||||||.||.| pkekvkladgkikvlalseekeegyiltrlrlek--kgetrrlvHfwyntWpdhgvpreedsslstdqllkmlravrrvrkeldkaePllvHcsaGvgRt GTFCLADTCLLLMDKRKdpsSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE |. . |... |....| .||. ... |.|| || |.|. .| .. | ||.| GtliaiDiavrlLeetk---kvdvlaiieelRkdRmalvqhpeqyellykavve |
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| Phosphatase | PTPN1.AA | Subfamily.N5_RR.PD | 35-275 | 33 | 1.3e-61 | 199.8 | In-house | 18-261 (265) | Show / Hide |
Range on Protein: 35-275 Range on HMM: 18-261/265 Sequence Identity: 33% (81 aa) AKLPKNKNRNRYRDVSPFDHSRIKLH-----QEDNDYINASLIKM-EEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQK ........|||... | ..||. |. .|| .|||| || .| .. |. |||||||| ||.|....... .||| .. |.|||.|.|..|. | levfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntiadfWrmiyqeevqvivmltklkeanrqkcavyfPda EEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTqETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEH-GPVVVHCSAGIGRSGTFCL . . ...... . . |.||.| |..|. .|.. |. || ||| .|... ..|... .|.|| . . .. .|||||||||||| | | .. . edyeiserygdveikveeiverndysvrklvlkyler-versvkhywytdWPdhksPddintlldlvleveesreeenaklaPvvvhcsaGiGrtGcfia ADTCLLLMDKrkdPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVI . ... . ||. |. ..| | |..||..| .. . |.. isiavrqlre---eivvdvlkivcnlrldrGGmvqtseqyelihralc |
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| Phosphatase | PTPN1.AA | Subfamily.RA.PD | 32-276 | 35 | 1.4e-61 | 199.7 | In-house | 19-263 (266) | Show / Hide |
Range on Protein: 32-276 Range on HMM: 19-263/266 Sequence Identity: 35% (89 aa) CRVAKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQ .|.|....||..||. .. |.|.||. | . |. |||||| |. . . ..| .|||. .| || |.||||| .||| . |.. |||||||. lrtankeenkkknrvvqilpydfsrvilsvkeGeeesdyinasfidGyrekdkfiaaqGpkeetvedfwrmiweqksativmltelkerkeekcaqywpd KEekemIFEDTNLKLTLISEDIKSYYTVRQLELENLT----TQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHgPVVVHCSAGIGRSG . .. ...... | . ||||.. ...|. ...| . ||.|.||..||| .. |..| ||.. | .| |.|||||||.||.| eG----lvtyGeirvevkdetvledytvrdflvtqlpdatrekksrlvrqfhftswpevGvpaegkGmlkllkkvkklqqqsanh-pivvhcsaGvGrtG TFCLADTCLllmDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE ||. |. | .. | .|. ... ..|. | ..|| | | | .. | tfivldavl---ervkaerkldvfeavkrlrlqrpqmvqtleqyefiykvlle |
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| Phosphatase | PTPN1.AA | Subfamily.R_Ecdysozoa.PD | 27-276 | 34 | 5.7e-60 | 194.3 | In-house | 14-266 (269) | Show / Hide |
Range on Protein: 27-276 Range on HMM: 14-266/269 Sequence Identity: 34% (90 aa) ASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH----QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLkCA .. ..|.. |. .|||.|. .||. |.||. .|| |||||| || . ....| |.|. .| | || |..||.. .||| . || ||. eiskstkvsekkenalknryedikafDktrvkLkkingkedsdyinasfikgykekkkfiaaqdPveatigDfWrmiaeqevtlivmlsnlteknrk-ca QYWPQKeeKEMIFEdtNLKLTLISEDIKSYYTVRQLELENLT---TQETREILHFHYTTWP-DFGVPESPASFLNFLFKVRESGSLS---PEHGPVVVHC |||. .|. .. .. .|.||. .|.|. |.|.. . ...|... ..||.|. |. |||... |... .||| .|. ..|.|||||| kyWpie--devqyg--dilvklvseekhsdyiireldvskkkeesvedsrkvvqysytgWksDskvPevargllklieqvrelyklnklsgsrsPivvhC SAGIGRSGTFCLADtclLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE | ||||.| | ||... | .||| .. ..|. | |.| .| || |... saGvgrsgifvald---lllqqlkaedkvdifetvkkLrsqrnllvqsleqyvflyralad |
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| Phosphatase | PTPN1.AA | Subfamily.RN.PD | 24-276 | 41 | 1.7e-59 | 192.7 | In-house | 11-261 (264) | Show / Hide |
Range on Protein: 24-276 Range on HMM: 11-261/264 Sequence Identity: 41% (105 aa) RHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQE----DNDYINASLIKMEE-AQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGS ..|| . . ||| .|| ..||...| |.||||.||..| ..|||||| | .. . .|| |||||..| .||.||||| . .|.| |. |.| ayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplsstiadfwqmvweqGvvvivnltrleeegv LKCAQYWPQKEEKemIFEdtNLKLTLISEDIKS-YYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESgsLSPEHGPVVVHCSA .|..|||.. .. ... .. |.|| | . | || . | || |.||| . ||. .||. ||| |. |.|.| || ||.|||||.| ||.|.. kqckrywpdeGse--vyh--iyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnks--yrGrscpivvhcsd GIGRSGTFCLADTCLLLMDkrKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE .| | | . | .|| | .| | ||..| ||..| . ||.| GaGrtGvyilidlvlerll--kGvkeidiaatlehlrdqrpglvktkdqfefaltavae |
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| Phosphatase | PTPN1.AA | Subfamily.N23.PD | 53-278 | 34 | 3.2e-57 | 185.6 | In-house | 115-349 (350) | Show / Hide |
Range on Protein: 53-278 Range on HMM: 115-349/350 Sequence Identity: 34% (82 aa) DHSRIKLH-----QEDNDYINASLIKMEEA-QRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDtnLKLTLIS |..|.||. .. .|||||. .| . ..| ||||...| . || |||||.|. .||| . |.. |||.||||..|.. . |.||...| |. dpnrvklqqstqpgqqddyinatylkeltpmsPpfiatqgPiastlaDFWlmvweqqssviVmltkevegnklkcdqYwPidegetnlfgd--lrvslks EDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESG------SL-SPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDkrK ... |.|.|. .. |.. |.|.|||...|||.|| ..|.|| .|.. . |...|||||.||.||||. . . .. .. lrssegwiervlhlqhndvstvrlvchlhtttWseiGvPksPedllaflgevetayaqqrktetegeggkPiilhCsaGvgRtgtfcvvysairelt--a DPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGA ..| .|. ..|. | .|. ..|...| ||.| | gngiiniprvvrrlrqqRkymvqkkvilkklyeavleaa |
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| Phosphatase | PTPN1.AA | Subfamily.N_Nematode_1.PD | 38-269 | 35 | 1.3e-50 | 163.6 | In-house | 24-255 (265) | Show / Hide |
Range on Protein: 38-269 Range on HMM: 24-255/265 Sequence Identity: 35% (85 aa) PKNKNRNRYRDVSPFDHSRIKL--HQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIF .....|||.||. |..|.|| . .||| | . . . .| .|.|| .|. .|| || .| .||| ...||||||.|.| ||.... |... aqeadknrykdvgcldknrvklaeeplpsdyihanyvgtptnpkrficaqaPldktiadfwymvlqekveaivmlckliekgkkkcaeyfpakegeklef EDTNLKLTL-ISEDIK------SYYTVRQLELEnLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESgslspeHGPVVVHCSAGIGRSGTFCLA . |.|. | ..| . .| .||.| . ..||.. |...| ||| |||. . |..|.||.| .||.||||||||||.|| . kekgqkitvenslgvkkleedeevikvtvleve-gaGektrkvthyqWtdWPdrGvPpadlaalelleavrgs------kgPivvhCsaGiGrtGtivai DtclLLMDKRKDP-SSVDIKKVLLEMRKFRMGLIQTADQLRF ...|| . . |..|.. ..|. | ||| | | e---yildkllegkqiedmeklvkkireqrnysiqtdaqylf |
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| Phosphatase | PTPN1.AA | Subfamily.RC.PD | 18-276 | 29 | 2.4e-50 | 162.9 | In-house | 4-285 (288) | Show / Hide |
Range on Protein: 18-276
Range on HMM: 4-285/288
Sequence Identity: 29% (84 aa)
AIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKL-----------H------------QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGH
| .| . . | .. ..|. ..||..||| || |.|. |..| | .| .||||| |. . || .||||.| . |
aefqrlpsvrskrtikiarkeenksknrysdvlpydynrvelkhelemskesehdsdessdddidseegskyinasfidsykkpekyiaaqGplketvdd
FWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWpqkEEKEMIFEDTNLKLTliSEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNF
|.|..|.| . .||| .. | |||.|| || . . | ...| .| | |..|.||| | ...||. .. ||.|....|| | .|...
fwrmiferkvkvivmltelkeGdrekcaeyw---eeGkrayGdvevdlk--dtdkssdyilrklelvnkkrkdsrevtqiqytswsveqlpeepkellkl
L-------F-KVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTcllLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
| . . .|..|||..| .|.|.|. .. |.. . ||. .|. ..|| | ..... .|. | ...|
iqvvkqklpqkrsseafknfkstpllvhcrdGsqrtGifialla---llesleaeekvdvfqvvkklrkarplmvsveeqyillydvlve
|
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| Phosphatase | PTPN1.AA | Subfamily.N20.PD | 36-276 | 37 | 9.1e-49 | 157.9 | In-house | 22-254 (257) | Show / Hide |
Range on Protein: 36-276 Range on HMM: 22-254/257 Sequence Identity: 37% (89 aa) KLPKNKNRNRYRDVSPFDHSRIKLHQeDNDYINASLIKMEEAQR--SYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEM . | |...|||||. |.| .|. | . .|||||| |.. .. || ||||| .| ||.|| |..| . |. | .| | .|| .|||.| . | nqpsnreknryrdilpydstrvplgk-skdyinasyirivncgeeyfyiatqgpllstiddfwqmvlennsnviamitreieggiikcyhywpislkkpl ifEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGsLspeHGPVVVHCSAGIGRSGTFCLADTCLL ... | .| |. .| ... . .| .. . ....| |||.| | | ||.... |.| | ||.||||||||||.| | | . . --elkhfrvflenyqilqyfiirmfqvvekstgtshsvkqlqftkwpdhgtpasadsfikyiryarksh-l---tgpmvvhcsagigrtgvflcvdvvfc LMDKRkdpSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE | |..| .. .||. | |..|| .| .| | |.| aivkn---csfnimdivaqmreqrsgmvqtkeqyhfcydivle |
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| Phosphatase | PTPN1.AA | Subfamily.N_Nematode_4.PD | 20-276 | 29 | 1.4e-47 | 153.8 | In-house | 6-261 (264) | Show / Hide |
Range on Protein: 20-276 Range on HMM: 6-261/264 Sequence Identity: 29% (78 aa) YQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQE--DNDYINASLIKMEeAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKG .| ... . . ||...|||.|. |..|. |.. ||||| || ..| . || |||||..| || ||...| |||| .|.| trdfvkgkappnvtasaseknsdknryadilcidetrvvlknrdpdndyihaswmrmP-dkfryistqGPlketlsdfwhmvytekiavvvmlcdlieeg SLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLT-----TQETREILHFHYTTWPDFGVPESPASFLNFLFKVREsgslSPEHGPVV |||.|.|.|.|| . | . ...|. | . . .. |.. | . | . |.... |.| |. .|. .... |.. ....|.|| vekcaryypeksekvvkfGkyritlvekkeeviadvilnslkvtntekkkdapseplvvkhvqvdwwrdqvaPldaapviklykavkk----kkkekPiv VHCSAGIGRSGTFCLADTCLLLMdkrKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE |||||.||. |. | . . . .. |.... ... |.|. |.. .|.| | .. .|| vhcsaGvGrtatlvGidyatiri---renseievldivrelramrlkavqshlqflfllvvlie |
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| Phosphatase | PTPN1.AA | Subfamily.R_Nematode_3.PD | 22-276 | 27 | 5.7e-47 | 151.8 | In-house | 21-264 (267) | Show / Hide |
Range on Protein: 22-276 Range on HMM: 21-264/267 Sequence Identity: 27% (72 aa) DirheasdfpcrvaklpKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINASLIKMEEAqRSYILTQGPL--------PNTCGHFWEMVWEQKSRGVVM . |. . .|. .|. . ..|..|.. .|.|.|....... . ||||.|. .|.|| |. ..|. |||| s----------------kkvsedrrvevpllektrvvLkgygkrfkddfihAnvvecpng-lklIltqsPqkkdkekkkkstieKfwwmieqekveqvvm LNRVME---KGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELeNLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESgslsp ..| ... ||..|.|.|...|. ||. ..| | |... . |.|.. .. ... . |.|. |.. ..||.| ..|. . .|..| lcdfveedgeeeekcseYypekvdgelkfegvsvkctdikkelsedvekrtlvv-tfekkkeftvthllykgWkelnapeepkealelikfveks----- eHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDpsSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE |||||||.||.||.|. .. |. |.|. ..|. ... |.|| || |||. .| |. | ... -ktpvvVHCsdGisRsatlaaielgyqliikskg--kldllslikelrkqRagaiqtelelafvilgilk |
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| Phosphatase | PTPN1.AA | Subfamily.N_Nematode_6.PD | 20-276 | 32 | 9.8e-47 | 151.0 | In-house | 6-250 (253) | Show / Hide |
Range on Protein: 20-276 Range on HMM: 6-250/253 Sequence Identity: 32% (81 aa) YQDIRHEASDFPCRVakLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSL |.| |||. ... . |.|.||||... .| .|.|| .... || |.|.|. .| .| ||.|| .|. .||.|. .. .||| ..|||. | ykdspneaseseata--flkfkdrnrytniqCcdagrlkladdedfyihanlvkistkprrlictqaplegtieefwkmilssgveyivmlcelvekgke KCAQYWPQKEEKEMIFEDTNLKlTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVREsgslspEHGPVVVHCSAGI .|.| ..| ... . . . . |... . .|| | ...| . |.|. ||| |||.|| | .| |.. .. |.|||||||.|| ksaeylsdkvGdarkitklctv-ikigrkdidkilvrslkrivkagdeevivkhihWanWPdhGvPdsflsalrllsvvkk------dkkPivvhCsaGv GRSGTFCLADTcllLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE ||. | . ... . | ..|..| .|. |. .|| | . .|.| GrtGtlalili---ilealrlpdfqgvkdllvklreerfravqtevqylyalrcvle |
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| Phosphatase | PTPN1.AA | Subfamily.R_Nematode_2.PD | 40-272 | 31 | 1.2e-45 | 147.4 | In-house | 29-254 (261) | Show / Hide |
Range on Protein: 40-272 Range on HMM: 29-254/261 Sequence Identity: 31% (73 aa) NKNRNRYRDVSPFDHSRIKLHQEDND-YINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDT .|...|| || ...... .... | | . .. .. .| ||||| ||. || || .| .||| ...|| ||..|.| ...... .. pkdkhRypdvPCkpetavevivdgkrvpihanwvptagnpkrfiatqgPlentsedfWamviqekvekivmlcqkvekekekceeYfpletsqkldlgrf NLKLTLISEDIKSYYTVRQLELENLTT-QETREILHFHYTTWPDFGVPESPASFLNFLFKVRESgslspeHGPVVVHCSAGIGRSGTFClADTCllLMDK ..| . . .| ..|.|. |. | .|| . |. |. ||| |||.| | . | |..|. |.||||||||||...| . . | .. . . siktvsaekilkdeiekrtlkvedstgkfatrtvthyqyeeWpdrgvPkshaelfeLlelvkks------ekPivvhCsaGiGRtmafi-gtey--lare RKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYL . ... | |.|..|. ||| || . | veadptieltealkelrehRwkgiqtesqlywltl |
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| Phosphatase | PTPN1.AA | PTPc_motif | 170-276 | 41 | 5.4e-44 | 153.39 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 170-276 Range on HMM: 1-92/92 Sequence Identity: 41% (46 aa) EILHFHYTTWPDF-----GVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTA .. |.|||.|||. |||| |.| |. .||. |.|||||||.||.||||..|... . |||.... |||| |.|..|| TVHHYHYTNWPDHVEKDSGVPE--DSILEFIRHVRK---------PIVVHCSAGCGRTGTFCAIDMMMQQ---------VDIFQTVKEMRKQRPGMVQTE DQLRFSYLAVIE .| .| | ...| EQYIFCYRCILE |
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| Phosphatase | PTPN1.AA | Subfamily.N_Nematode_5.PD | 37-275 | 28 | 1.8e-39 | 127.0 | In-house | 22-254 (258) | Show / Hide |
Range on Protein: 37-275 Range on HMM: 22-254/258 Sequence Identity: 28% (69 aa) LPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCaQYWPQKEEKEMIFE ||...||. || |..|.||..||..||||| ||........|||| |||.| ||.|| ..| ||.| . | . .. ...|..... . ... feknlkknrskdvkilDetrVkltdeddsYinaskiklddlekkliltQlPlpdteedFWrmvyqekitsvvllvedeelketav-sffpletgdylnlg DTNLKLTLISEDIKSYytvRQLELENLTT--QETREILHFHYTTWPDFGVPESPASFLNflFKVRESGSLSPEH-GPVVVHCSAGIGRSGTFCLADTCLL . . . .. . . .. .| | | . . |.|||.. ||.. . .. ... .| . . ||||....|.||.||| |... ... kmfinnrkvevkedek---keytvevlpegcsesvfakvyhlttWkkkkvPdkvkkvik--raiekvlskkqgknapvvvvsdlGlgRagtflllsvaie LMDKRKDPSsvdIKKVLLEMRKFRMGLIQTADQLRFSYLAVI | | |...| ..|. |.| .....| . | ||. qlnngkepn---ideilkkirsqRpgavesliqyasvyaavl |
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| Phosphatase | PTPN1.AA | Subfamily.N_Fungi_PTP1.PD | 42-131 | 30 | 9.8e-22 | 68.9 | In-house | 47-154 (343) | Show / Hide |
Range on Protein: 42-131 Range on HMM: 47-154/343 Sequence Identity: 30% (33 aa) NRNRYRDVSPFDHSRIKLH------------QEDNDYINASLIKME----EA--QRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQ .|||... |..|||.||. . ||||||. .|.. | . || ||.|||.| |.... . | . ...|. .| . || .| aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr YWPQKEEK |.. . . YWqegsyd |
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| Phosphatase | PTPN1.AA | Subfamily.N_Nematode_eak.PD | 33-203 | 30 | 1.3e-21 | 68.7 | In-house | 19-187 (281) | Show / Hide |
Range on Protein: 33-203 Range on HMM: 19-187/281 Sequence Identity: 30% (51 aa) RVAKLPKNKNRNRYRDVSPFDHSRIKLHQ---EDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKE ||.. .. |||| .. |.|. ..| . . ||||||... | | |||| . . ||.|| |||| .|.|.|.. | .|.|.| .. rvtarleavnrnrvvkivpqdrylvrltssqlnrdGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledveekleksdkyfpdkt eKEMIFEDtnLKLTLISEDIK-SYYTVRQLELEnlTTQETREILHFHYTTWPDFGVPESpASFLNFLFKVRESGS . . |... . .| . . .|.|.|. .|| ..||... | .. .| ||. ..| | -evlkyGi--ldverkeyavkrniletrllilr--kGnethrvlhykvfGwtettlpky-edflalrkvmkevGv |
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| Phosphatase | PTPN1.AA | Subfamily.N_Fungi_PTP1.PD | 153-274 | 26 | 3.1e-14 | 44.2 | In-house | 195-338 (343) | Show / Hide |
Range on Protein: 153-274
Range on HMM: 195-338/343
Sequence Identity: 26% (37 aa)
YTVRQLELENLT--TQETREILHFHYTTWPDFGVPESPASFLNFLF--------KVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLL---LMD---
..... .| .| | |...... |.| .. | |.|. | . || . . . |..||||||.|| ||..| | .. |
dlnnnndltpvtaavsepyevyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenlt
K----RKDPSS--VDIKKVLLEMRKFRMGLIQTADQLRFSYLAV
. .. |. ...|.|| |. ..|. || | | |.
kesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeal
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| Phosphatase | PTPN1.AA | Family.DSP.PD | 155-228 | 30 | 9.4e-09 | 26.5 | In-house | 148-205 (387) | Show / Hide |
Range on Protein: 155-228 Range on HMM: 148-205/387 Sequence Identity: 30% (18 aa) VrqlelenlttqetREILHFHYTTWPDFGVPESPASFLNFLFkVRESGSlSpEHGPVVVHCSAGIGRSGTFCLA .. ... ..|...| | ... . |.| . ..| |.||| ||.||||| . | k-------------elgikylripidDhnapplenlfekaid-fieegn-d-skgvVlVHCkaGkgRsgtliia |
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| Phosphatase | PTPN1.AA | Subfamily.PTPDC1.PD | 169-268 | 30 | 1.2e-08 | 26.2 | In-house | 133-218 (229) | Show / Hide |
Range on Protein: 169-268 Range on HMM: 133-218/229 Sequence Identity: 30% (30 aa) REILhFHYTTWPDFGVPeSPASFLNfLFKVRESgSLspEHGPVVVHCSAGIGRSGTFCladTCLLLMDKRKDPSsvdikKVLLEMRKFRMGLIQTADQLR ..| |. ...|.||. | . |. . || .. .| |.| . ||| || || | .| |. || ... . . .|. |||| .|.. qgiy-fynfglkDygva-sleriLd-ivkvvdf-al--eegkiavHCHAGlGRtGvli---acylvyakrltae-----eaiklvrskrpksiqtreqve |
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| Phosphatase | PTPN1.AA | Subfamily.DSP23.PD | 163-266 | 25 | 8.6e-08 | 23.8 | In-house | 25-116 (128) | Show / Hide |
Range on Protein: 163-266 Range on HMM: 25-116/128 Sequence Identity: 25% (26 aa) LTTQETREILHFHYTTWPDFGvPESPASFLNFlFKVRESGslSPEHGPVVVHCSAGIGRSGTFCladTCLLLMDKRkdpssVDIKKVLLEMRKFRMGLIQ . .|. . | .. ||| | .. .. ... | ....| ||| |.||.||. .| |. .. . .. . |.|| | | |.| apyseaapsltlrridipdfc-PPaleqvarl-vriveea--ekkeeavgvhcalGlGrtGtll---acylvkeeg-----laaddaiaevrkrrkGsie TADQ .| tveq |
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| Phosphatase | PTPN1.AA | Subfamily.DSP1.PD | 207-228 | 59 | 1.4e-06 | 19.9 | In-house | 78-99 (139) | Show / Hide |
Range on Protein: 207-228 Range on HMM: 78-99/139 Sequence Identity: 59% (13 aa) EHGPVVVHCSAGIGRSGTFCLA ..| |.||| ||| || |..|| kgGrvlvhCqaGisrsativla |
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| Phosphatase | PTPN1.AA | Subfamily.N_Nematode_eak.PD | 206-276 | 23 | 2.1e-06 | 18.8 | In-house | 210-278 (281) | Show / Hide |
Range on Protein: 206-276 Range on HMM: 210-278/281 Sequence Identity: 23% (17 aa) PEHGPvVVHCSAGIGRSGTFCLADTCLLLMDKRKDpSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE | . | .. .. | |.|.| . | . |.|..| . .....| ... |. . .| | | | .|.. psfap-iiqsarGsaraGvfvvidllirlidnkkk-nlysvedlilkvkskrihsvlvalqhsfiyeivld |
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| Phosphatase | PTPN1.AA | Subfamily.DSP12.PD | 207-228 | 50 | 4e-06 | 18.5 | In-house | 80-101 (143) | Show / Hide |
Range on Protein: 207-228 Range on HMM: 80-101/143 Sequence Identity: 50% (11 aa) EHGPVVVHCSAGIGRSGTFCLA ..| |.||| ||. || |...| kegavlvHClagvSRSvtiviA |
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