Gene PTPN2
PTPN2
Species: Human
Alias: PTPT, TC-PTP, TCPTP, PTN2, TCELLPTP, PTPN2
External Links:
COSMIC
,
Entrez Gene
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of PTPN2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | PTPN2.AA | PTPc | 4-277 | 36 | 2.5e-117 | 396.99 | SMART | 1-308 (308) | Show / Hide |
Range on Protein: 4-277 Range on HMM: 1-308/308 Sequence Identity: 36% (118 aa) TIEREFEELDTQRRWQPLYLEIRNESHDY----PHRVAKFPENR--NRNRYR-DVSPYDHSRVKLQN--------AENDYINASLVDIEEAQRSYILTQG ...|||.|.... |. . | .| . ..|..|||| ..|||. |. .|||.||||.. .|||||. .|... ...||.||| GFWEEFERLQRMTPWD-------LMS-NYDPCCSCTCACWPENREMDKNRYKCDIPCYDHTRVKLKPPPGESHCYEGSDYINANYIDGYWRPKRYICTQG PLPNTCCHFWLMVWQQKTKAVVMLNRIVEK--------ESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKS-YYTVHLLQLENINS--------GETRT |||.|. .|| ||||||....|||....|| .||.|||| . .| .. ...|...||.... .||.. ....| . .|||| PLPHTIEDFWRMVWQQKCHIIVMLCNCMEKCTENRDQNGREKCHQYWPDE--PMTYG--HITVTCKSEEKCPDDYTMRTFEVTNTGCNCKYSMACSETRT ISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPD-----------------HGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKY . |.|||.|||.|||||| |||.|. .||.. | .|. .|| |.|||||.||.||| ..|... ..|. ..|.|.. ||.. VTHYHYTNWPDHGVPESPDSFLDFIRQVRHWQSHSPNMYMNMVSSNSKYHHTCPTGPIVVHCSAGCGRTGTFCAIDIMCQQIEN---VDIFQIVKMMRNQ RMGLIQTPDQLRFSYMAIIEGAK |.|..||..|..| |..|.| .| RPGMVQTEEQYIFCYRCILEYIK |
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| Phosphatase | PTPN2.AA | Subfamily.N1.PD | 18-277 | 67 | 5.4e-141 | 460.0 | In-house | 2-268 (268) | Show / Hide |
Range on Protein: 18-277 Range on HMM: 2-268/268 Sequence Identity: 67% (180 aa) WQPLYLEIRNESHDY--PHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRI .....|||..||... ..|.||.||||..|||||||||||||.||..|..||||||||..|||.|.|||||||||.|..||| |||.|..|||.|||.. ykeilleidkeskekeletreaklpenrglnryrdvspydhsrikleradvdyinaslveleeakrrYiLtqGPLphtadHFWqmvWeqnskavimLnkv VEKESVKCAQYWPTDDQ--EMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAV |||...|||||||.... |.|..|| ..|||.||..|||..|.||.||.... |||.|.|||||||||||||||||.||.|||||||||||..|.|||| vEknqikCaqywpqeeeeaellleetklkvkliseerksyflvrlleLedletqetreilhfhyttwpdfgvpespaafLkfLfkvresgsLssdvgpav IHCSAGIGRSGTFSLVDTCLVLMEKGDD---INIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAK ||||||||||||.||||||||..|| .| ..||.|||..||||.|||||||||||||.||.|||| ihCsagigrsgtlslvdtclveiektgdlnavdikkvLlelRkyRvGLiqtpdqLrFsyiailegak |
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| Phosphatase | PTPN2.AA | Y_phosphatase | 42-274 | 44 | 1.1e-117 | 402.01 | Pfam | 1-243 (243) | Show / Hide |
Range on Protein: 42-274 Range on HMM: 1-243/243 Sequence Identity: 44% (110 aa) NRNRNRYRDVSPYDHSRVKLQ----NAENDYINASLVDI-EEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKES-VK-CAQYWPT--DDQ |...|||.|. .|||.||||| . |||||. .|. .. ||.||||.|.|. .|| ||||||....|||....|.. .| |.||||. ..| NKEKNRYKDIPCYDHTRVKLQPIPGDEDSDYINANYIDGPYWNPKAYICTQGPMPHTIEDFWRMVWQQKCTCIVMLCNCMEMGRDEKTCHQYWPDNKEGQ EMLFKETGFSVKLLSEDVKSYYTVHLLQLENINS--GETRTISHFHYTTWPDFGVPES-PASFLNFLFKVRESGSLNPDHG--PAVIHCSAGIGRSGTFS .| . .|.|.. ||.....|||. ....| .. .||||. |.|||.|||.||||| | |.|.|. .||.. . ||||| | |.|||||.||.||| PMTYG--DFQVTCVSEEHCPDYTVRTFEVTN-GDQKQETRTVTHYHYTNWPDHGVPESQPKSMLDFIRQVRKWQP-NPDHGCPPIVVHCSAGCGRTGTFC LVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE ..|... .||......|.|.. ||. |.|..||..|..| |..|.| AIDIMCQQMEHEGTVDIFQIVKHMRNQRPGMVQTEEQYIFCYQCILE |
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| Phosphatase | PTPN2.AA | Subfamily.N3.PD | 33-274 | 42 | 3e-78 | 253.9 | In-house | 17-258 (261) | Show / Hide |
Range on Protein: 33-274 Range on HMM: 17-258/261 Sequence Identity: 42% (104 aa) PHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQ----RSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWP .|. ||| ..|||||..|||. ||||...|.|||||. |..| || |||||..|. .|| |||.||.. .||| .||. ||| ||||. . aisaarkpenlaknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGplaktakdfWqmvweqkstlivmlttlverGrvkChqyWP TDDQEMLFKetGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLnpDHGPAVIHCSAGIGRSGTFSL .|. | .|||.. .|| .. | . | |.. .. | |.| .. |. ||| |||...|.||.|. .||. | .. | |.||||||||.| . |..| etedelefg--efsvrcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsg--keePvvvhCsaGigrtGvlil VDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE .| |.|. ..... ... .|| |. |.||..| .| ||.. letalalieaaepvypldivrtmrdqramlvqtvsqykfvCeailk |
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| Phosphatase | PTPN2.AA | Subfamily.RB.PD | 22-273 | 37 | 8.3e-76 | 246.1 | In-house | 6-257 (261) | Show / Hide |
Range on Protein: 22-273 Range on HMM: 6-257/261 Sequence Identity: 37% (96 aa) YLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKL----QNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVE | |... ..| ... |. ..||..||.. . ||||||||| .....|||||. .. . .| || ||||||.| .|| |||..|....||| ..|| yeelkkvgkdqavkaaeeavnraknrftnilpydhsrvkLaalkdesdtdyinanyipgynspreyiatqGPlpetvddfWrmvwekkssiivmltqlvE KESVKCAQYWPTDDQEMLFKEtgFSVKLLSEDVKSYYTVHLLQLENinSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCS | .|| .|||.|....|. . .|.||.|. .. .... ...|. |.|.. ..|.|.|||.||||.... |.|. .|||. ... ..| |.|||| kgkekceeYWPadeepvlyGd--ikvtllaekeldewvirefkiek--gkekrkvrqyhftsWpdhgvPektktlldfvrtvreaiekkaskkPivvHCs AGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAII |.||.||| .|. | .|. | ... |. ..|. |. |.|| .| | . ... aGvGRtGtfialdrllqaieendyvdvfgvvaelReeRnllvqtekqyifihecll |
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| Phosphatase | PTPN2.AA | Subfamily.N13.PD | 34-274 | 41 | 1.6e-75 | 245.3 | In-house | 18-256 (259) | Show / Hide |
Range on Protein: 34-274 Range on HMM: 18-256/259 Sequence Identity: 41% (101 aa) HRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENdYINASLVDI--EEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDD .|.| ||...||||.| |||..||||.. . ||||||. . .| . .||..|||||.|. ||.|||.||.. ..|. .||. |||.||| .. cevgkkkenkdknryrnvlPydetrvklgdegg-yinaslikvpvgedeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPerk QEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVResgSLNPDHGPAVIHCSAGIGRSGTFSLVDT | . . |.|| .. ..|. |......|||.| ..|.....||| ||| |.|....|. .|| .|. |.|| |.||||||||||.. .|. | nkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaelvqfvaevr---llqtdagPivvhcsaGiGrsGvlitidv CLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE |.|. ....|... ..|. | |..|| || | | ||.| vlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile |
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| Phosphatase | PTPN2.AA | Subfamily.N9.PD | 22-276 | 40 | 7.4e-75 | 243.2 | In-house | 6-274 (275) | Show / Hide |
Range on Protein: 22-276 Range on HMM: 6-274/275 Sequence Identity: 40% (105 aa) YLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAE----NDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVE |..||||. ..| . | ..||| || ||..||||.. . |||||. || . ....|.|||||..|. ||.|||.|.. .|||.||. yadirnepveGtflasklranleknrytdvlcydetrvklakldedeasdyinanfvdGykqkkafiatqGplkktvsdfwrmvweqevlvivmttrvve KESVKCAQYWPTDDQEMlFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSL-----------N .||.||||...... . . .||. .. .|.. |.|. |...|....|.|...|| ...|||.|||.| ||.|..| |||| .|... | |.||||| rgrlkcgqywpleeess-aefgdlsvsnveveveedykvrvleiknvkteesrkvthfqflswPdyGvPssaaslldvlekvrekqalavkelgdeskgh PDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGA |||.||| .| || .|. . ....... ..|. | ||||.| | |.|..| | lsgPPivvhcsaGiGrtGtfitldiclarleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya |
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| Phosphatase | PTPN2.AA | Subfamily.N_Choan_1.PD | 19-274 | 36 | 1.1e-71 | 232.6 | In-house | 3-259 (262) | Show / Hide |
Range on Protein: 19-274 Range on HMM: 3-259/262 Sequence Identity: 36% (95 aa) QPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKL----QNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNR . | .... | . . .| .||...|||.... ||..|||. .| ..|||||. |. . .. || ||||.|... .|| |||.|| .|.||. | ieeyeklaeigvdntataskadenvlknrysnivayDatrvkvtpneenkntDyinanfvpgykgekeyiatqgPvPaslvsfWqmvweqkvsaivmvtr IVEKESVKCAQYWPtDDQEmLFKETGFSVKLLSEDVKSYYTVHLLQLeNINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDhGPAVI .|.. .|| .||| |... | . . || ||| |. | . ..| . .|||||......||.||| |||.... .|.| .|.. . . . | || eieagklkChryWP-dens-elklgdvtvkslseeekktyierkfkl-eresgetreveqlaytaWPdhGvPattkellefrkavlkatkkktk-aplvi HCSAGIGRSGTFSLVDTCLVLMEKGDD-INIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE |||||.||.||. .|. . .|. . ...|.|. ..|| |. ..|| | .| | |. . hCsaGvGrtGtyialDrlvkaveekaealdvkavvaelrkernlmvqtlvqyefvykavld |
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| Phosphatase | PTPN2.AA | Subfamily.R_Anemone_1.PD | 28-274 | 36 | 2.7e-70 | 228.3 | In-house | 11-255 (258) | Show / Hide |
Range on Protein: 28-274 Range on HMM: 11-255/258 Sequence Identity: 36% (91 aa) ESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQN----AENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKC |... . ||. .||...||| |. ..||||| |.. | |||||| .. . .|..|.||.||..|. || ||||.|. ..|||. ..|.| || eikeeekevarkaenkkknryadivaldhsRvvLeklsndeesdYinasylrasdktrafiatqapleetvedFWrmvwqekigviVmLtnliegekkkc AQYWPTddQEMlfKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESgsLNPDHGPAVIHCSAGIGRS ||||. .. | . ..|.| ...|.. |.. | |.. .. |.|.. ..|.|.||| |||. .. |... ||..| .... | |.|||||.||. hqYwPd--ste--kygelrvslrkkevfadyiirtlvlskkketeerevvqyhftvWpdkgvPqyatavLglrrkvqks--slagarpvvvhCsaGvgRt GTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE |.| .|. | . | ..| ... ..|. | ..|| .| | ..|..| GaflvidamleqakkekvvDifnyvkairedrphmvqtkeqyvfihlavle |
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| Phosphatase | PTPN2.AA | Subfamily.N12.PD | 28-274 | 37 | 3.5e-68 | 220.9 | In-house | 18-267 (270) | Show / Hide |
Range on Protein: 28-274 Range on HMM: 18-267/270 Sequence Identity: 37% (95 aa) ESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNA----ENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKC ... |. ... .||...|||.|. |||.|||.|.. ..|||||... | . .|| .|||||.| || |.|..... |||. |.|| . || aekvysteagekeenvkknrykDilPydksrvelskieeeegsdyinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkC AQYWPTDDQEML-FKEtgFSVKLLSEDVKS-YYTVHLLQLENInsGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSlnPDHGPAVIHCSAGIG ..||| .| | | | |.|.| .|. . ... |..|. .|.|.. |||| ||| |||.|. | |... .||| ... | |.|||||.|| | eryWpeegeeelefge--fevtleeekavdddflirtLkveaq--kesrkvyqfhytaWPDhgvPssaksllelielvrelqe--sedaPlvvhCsaGvG RSGTFSLVDTCLVLMEKGDD---INIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE | .| |.... ... ...|..|| | |.|| .| .. |.|..| rtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae |
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| Phosphatase | PTPN2.AA | Subfamily.R_Anemone_2.PD | 26-274 | 35 | 2e-66 | 215.5 | In-house | 11-259 (262) | Show / Hide |
Range on Protein: 26-274 Range on HMM: 11-259/262 Sequence Identity: 35% (91 aa) RNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNA----ENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESV |.|.. . | | |...||| .. .||..|||||. . |||||. .| .....|| ||.|||.|. || |||.|... .||| ...|. . rseetsvtlksalepvnkaknryanilaydktrvklqmlegeegsdyinanyidGyrrkkayiatqaPlpetiedfWrmvWeqnsavivmltqeeergka KCAQYWPTDDQeMLFKEtgFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESgSLNPDHGPAVIHCSAGIG |...||| .. . ... |.| .| |.|.. ..... .. |.|.. ||||.||| |||||.||.|... .|.. ....|| |.|||||.| kvhryWPskgs-rsygk--lvvelkeevelsdyvlrsfkvkrteeeeerqvrqfhytsWpdegvpesgaslldlvrqveka-qqesgagpivvhcsaGvG RSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE | |.| ||. | ... ... |.. ..|. | ..|| || | | ...| rtGvfiavdillerikaealvdvfqtvkqlreqrnlmvqtkdqyefiydvlle |
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| Phosphatase | PTPN2.AA | Subfamily.N6.PD | 25-272 | 34 | 2.9e-66 | 215.0 | In-house | 23-290 (295) | Show / Hide |
Range on Protein: 25-272 Range on HMM: 23-290/295 Sequence Identity: 34% (94 aa) IRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNA-----ENDYINASLVD-------------IEEAQRSYILTQGPLPNTCCHFWLMVWQQKT .. .. | .. .. .||.. |||... |.||.||.|.. .|||||. .. || |..|| |||.|..| || ||||.... kqeseklysrkegekienkeknryknilPfDhtrvilkdgepsvpgsdYiNanyirlpkaskssgenveseehqkryiatqgcLkdtvsdFWrmvwqens KAVVMLNRIVEKESVKCAQYWPTDDQEMLfkETGFSVKLLSEDVKSYYTVHLLQLENI-NSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSL .||. . ||. |||.|||. .. .|. .||. .. ||. ..... . |.|.| ..|...||| |||..| .|||| .|.. . rvivmttkevergknkCarYWPdeetkke--tGvitvtsisEkstadYtlRefsvshkdkdkeareifqyhfkaWPdhgvpkdpgvvlnfledvnkkqee NPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKG---DDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAI ..|| |.|||||||| ||| ..|. | ..|. ||.|.... ..|..| ||.|| .|..| |.|. lekagpivvhcsaGiGrtGtfividivlkiieqsgldvdidisksikdvrsqrsglvqteaqykfvykav |
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| Phosphatase | PTPN2.AA | Subfamily.R_Sponge_2.PD | 30-274 | 34 | 3e-65 | 211.6 | In-house | 13-259 (262) | Show / Hide |
Range on Protein: 30-274 Range on HMM: 13-259/262 Sequence Identity: 34% (84 aa) HDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQN---AENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQY .. || .|| .||.... |||.|||.|.. . |||||| || . . .|| |||||..| || ||| .|.. .|||..|.. |||.||| tefslsiaklkenvgKnRfkeilpydmsRvrLrtdgskdsDYinAsfvdgykrrkayiatqgPlketveDfWRmvweykvstivmltnleengkekcakY WPTDDQEMLFKETGfSVKLLSEDVKSYYTVHLLQLENINS-GETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESgSLNPDHGPAVIHCSAGIGRSGT . .| . |.| .| . |... |.| . .| ........||...||. .||.. .|.|....|... . .. ...||.|.||.||| WPekvdeeveygkf-kvtlkeeekladyiirklklskekssegeadvtqfhfvaWpehevPkdatsllelikrvlra-qkksgnkaitvvCsdgvgrtGt FSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE .|. | ... ..|.. .|| ..| |.||.|. .| | . |. | fialdsvlerlkaeeeidvfevlktlrtkriglvqdaaqYvfihdalle |
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| Phosphatase | PTPN2.AA | Subfamily.N14.PD | 22-274 | 38 | 1.9e-64 | 208.8 | In-house | 6-272 (275) | Show / Hide |
Range on Protein: 22-274 Range on HMM: 6-272/275 Sequence Identity: 38% (101 aa) YLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQ---NAENDYINASLVDI--EEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIV | .| ....| .|| ||| ..||..|| ||...||.|. .....||||| . . ..|||| .||||..|.. || |||.|... .||| .. yeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfwqmvweqgvqlivmlteee EKESVKCAQYWPTDDQ-EMLFKETGFSVKL-LSEDVKSYYTvHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVR----ESGSLN---- |. |. .|.| ... . . | | .||| .|. | . |.|. . |.| ||. |. || ||| |||| . .||.|| .|... | . . edgkeksfkylPkleskkktvefgkfkvttkfsedsdsvit-tglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsfLeevqsvrrktnsevesvk PDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE | ..|||||.||.| |.| . .|....|.||.|| .|| || |.|| | .| | ..|. eskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLrkqrmllvqtlaqykfvykvlik |
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| Phosphatase | PTPN2.AA | Subfamily.RG.PD | 25-274 | 36 | 4.5e-64 | 207.7 | In-house | 9-261 (264) | Show / Hide |
Range on Protein: 25-274 Range on HMM: 9-261/264 Sequence Identity: 36% (93 aa) IRN-ESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAE----NDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKE | . ...| . .| .||...||. .. ....|||||.. .|||||| .| . .. || |||||..|. || |.|..... .|||..|| iqklkpkdieaesskkeenkeknReinivaversRvklsplpgkdgkDYinAsyidGyrrskeyivtqgplketiedFWrmiWehnaqiivmltdldekg SVKCAQYWPTDDQEMLFKEtgFSVKLLSEDVKSYYTVHLLQLENINSGETRT--ISHFHYTTWPDFGVPESPASFLNFLFKVreSGSLNPDHGPAVIHCS ....|||..|. . ... ..|.|||....|.|||. ..|.|.. . .. . ..|||.||| |.||| . .|.| | . .. . || |.|.||| rrdedvyWPkkdeplelea--lkvtllskeklskytvrdfvlkntkddkekervvrqyhytkWPdmgsPestlfvlifvkke--eaankeeaGPivvhds AGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE ||.||. .|| | .|| . .|. ||| .|. | ||..| .| .| | |..| aGvgragtyialdtllqqlekeeavnvyqvlklirakRpglvtteEqyvfiydalle |
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| Phosphatase | PTPN2.AA | Subfamily.N_Choan_2.PD | 34-274 | 35 | 5.3e-64 | 207.2 | In-house | 13-263 (266) | Show / Hide |
Range on Protein: 34-274 Range on HMM: 13-263/266 Sequence Identity: 35% (89 aa) HRVAKFPENRNRNRYRDVSPYDHSRVKLQNAEND----YINASLVD-IEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWP ... .. |.. |||.|. | ..||.|.. |.| |||| | .......|| ..||||.| .|| |.|..|..|.||. ..|| ||..||| eaiPeyarnkrlnRyndiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWp TDDQEM-LFKETGFSVKLLSEDVKSYYTVHLLQLENinSGETRTISHFHYTTWPDFGVPESPA------SFLNFLFKVRESGSLNPDHGPAVIHCSAGIG .. .| ... .| ||| .. | . |.||. .||||.. ||.|.|||| |||... . |.| .||.. . . .| ..|||||.|| aepkekvkladgkikvlalseekeegyiltrlrlek--kgetrrlvHfwyntWpdhgvpreedsslstdqllkmlravrrvrkeldkaePllvHcsaGvg RSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE .||. ..|... |.|. ... ... ..||.|| |.|.|.| .. | |..| RtGtliaiDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyellykavve |
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| Phosphatase | PTPN2.AA | Subfamily.RK.PD | 34-274 | 32 | 6.3e-63 | 203.7 | In-house | 21-264 (267) | Show / Hide |
Range on Protein: 34-274 Range on HMM: 21-264/267 Sequence Identity: 32% (80 aa) HRVAKFPENRNRNRYRDVSPYDHSRVKLQNAE---NDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRI-VEKESVKCAQYWPT .|| ..||..||. |. .||.|.|.|. . .|||||.|.| . . .| |||||..| || .|..... ..|||. . ||. |||.||| | cdiakkdrnreknrsmdilaydrslvflisvdgdssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmlteldvevgrvkClkyWPe DDqEMLFKEtgFSVKLLSEDVKSYYTVHLLQLENI--NSGETRTISHFHYTTWPDF-GVPESPASFLNFLFKVRESGSLnPDHGPAVIHCSAGIGRSGTF |. ... . |.|.. .... . | ....|.. . |.|.. .|....||.. .||.| |.|... .| .| . ..|. |.||.|| |||||| . dt-evrygd--ikvelveaeldadlvvrifrveklargqeeirevrqfqflgWpeyrdvPvskrsllklirrvkksqee-eeeGrivvhClaGaGrsGtf SLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE |. | ..|. . ... .. ..|.... ...| .| .| | .|.| iaidivlemieregvvdvfnavktlrnrkvnmveteeqykfvydvile |
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| Phosphatase | PTPN2.AA | Subfamily.N5_RR.PD | 37-274 | 30 | 2e-60 | 195.7 | In-house | 18-262 (265) | Show / Hide |
Range on Protein: 37-274 Range on HMM: 18-262/265 Sequence Identity: 30% (73 aa) AKFPENRNRNRYRDVSPYDHSRVKLQN-----AENDYINASLVD-IEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTD . . . ..|||... | ..||| |.. . .|||| . .| .. |. |||||||| ||.|..|.... .||| .. |..|||.|.|.. levfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntiadfWrmiyqeevqvivmltklkeanrqkcavyfPda D-QEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSgETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDH-GPAVIHCSAGIGRSGTFSL |. . .....| . . |.|. | |.. .. .|.. |. || ||| .|... ..|... .|.|| . . . .| |.|||||||| | | .. edyeiserygdveikveeiverndysvrklvlkyler-versvkhywytdWPdhksPddintlldlvleveesreeenaklaPvvvhcsaGiGrtGcfia VDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE .. ... ... .. |.| | |..|| .| .. . |... isiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl |
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| Phosphatase | PTPN2.AA | Subfamily.RA.PD | 34-274 | 34 | 6.2e-60 | 194.1 | In-house | 19-263 (266) | Show / Hide |
Range on Protein: 34-274
Range on HMM: 19-263/266
Sequence Identity: 34% (86 aa)
HRVAKFPENRNRNRYRDVSPYDHSRVKLQNA----ENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPT
|.|. .||...||. .. |||.||| |.. | |||||| .| . . ..| .|||. .| || |.|.||....||| . |.. |||||||..
lrtankeenkkknrvvqilpydfsrvilsvkeGeeesdyinasfidGyrekdkfiaaqGpkeetvedfwrmiweqksativmltelkerkeekcaqywpd
DDqemLFKETGFSVKLLSEDVKSYYTVHLLQLE----NINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHgPAVIHCSAGIGRSGT
|. |.. | | ||| . .. . . ..| .. ||.|.||..||| .. |..| ||.. . .| | |.|||||.||.|||
eG---lvtyGeirvevkdetvledytvrdflvtqlpdatrekksrlvrqfhftswpevGvpaegkGmlkllkkvkklqqqsanh-pivvhcsaGvGrtGt
FSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE
.|. | .. . ... ... ..|. | ..|| | | | .. |
fivldavlervkaerkldvfeavkrlrlqrpqmvqtleqyefiykvlle
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| Phosphatase | PTPN2.AA | Subfamily.RN.PD | 27-274 | 40 | 5.9e-59 | 190.7 | In-house | 12-261 (264) | Show / Hide |
Range on Protein: 27-274 Range on HMM: 12-261/264 Sequence Identity: 40% (100 aa) NESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQN----AENDYINASL-VDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESV |... . ||| ..| ..||...| |||||||||.. ..|||||| .| . . .|| |||||..| ..|| |||.| . .|.| |.|.. .| yeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplsstiadfwqmvweqGvvvivnltrleeegvk KCAQYWPTDDQEMLfkeTGFSVKLLSEDVKS-YYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESgsLNPDHGPAVIHCSAGI ..||| . .|. . |.|.|| . . | | . | |... ||||.. ||. .||. ||| |. |.|.| || || |.|||.| ||.|.. |.| qckrywpdeGsevy---hiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnks--yrGrscpivvhcsdGa GRSGTFSLVDTCLVLMEKG-DDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE | . || .|.| | .| | ||..| ||..| ..|..| GrtGvyilidlvlerllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae |
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| Phosphatase | PTPN2.AA | Subfamily.R_Ecdysozoa.PD | 34-274 | 33 | 3.4e-57 | 184.9 | In-house | 19-266 (269) | Show / Hide |
Range on Protein: 34-274 Range on HMM: 19-266/269 Sequence Identity: 33% (83 aa) HRVAKFPENRNRNRYRDVSPYDHSRVKLQN----AENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVkCAQYWPT .|.. || .|||.|. ..|. ||||.. .. |||||| . . ....| |.|. .| || |...|. . .|||. ||. ||.||| . . tkvsekkenalknryedikafDktrvkLkkingkedsdyinasfikgykekkkfiaaqdPveatigDfWrmiaeqevtlivmlsnlteknrk-cakyWpi DdQEMLFKetGFSVKLLSEDVKSYYTVHLLQLENIN---SGETRTISHFHYTTWP-DFGVPESPASFLNFLFKVRESGSLN---PDHGPAVIHCSAGIGR |. . ||| ||. .|.|. |.. ... ..| . ..||.|. |. |||.. . |... .||| .|| ..| |.||||| ||||. e-devqyg--dilvklvseekhsdyiireldvskkkeesvedsrkvvqysytgWksDskvPevargllklieqvrelyklnklsgsrsPivvhCsaGvgr SGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE | .| | ... | ..| .. ..|. | |.| .| | | |... sgifvaldlllqqlkaedkvdifetvkkLrsqrnllvqsleqyvflyralad |
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| Phosphatase | PTPN2.AA | Subfamily.N23.PD | 52-276 | 35 | 4.6e-54 | 175.0 | In-house | 112-349 (350) | Show / Hide |
Range on Protein: 52-276 Range on HMM: 112-349/350 Sequence Identity: 35% (84 aa) SPYDHSRVKLQ-----NAENDYINASLV-DIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTD-DQEMLFKEtgFSVK | |..||||| . ..|||||. . .. ..| ||||...| ||||||.|... .||| . ||.. ||.||||.| .. .||. ..| | srhdpnrvklqqstqpgqqddyinatylkeltpmsPpfiatqgPiastlaDFWlmvweqqssviVmltkevegnklkcdqYwPidegetnlfgd--lrvs LLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESG-------SLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLME |. ... . |.|. . |...|.|.|||...|||.|| ..|.|| .|.. . | ..|||||.||.|||..| . . ... lkslrssegwiervlhlqhndvstvrlvchlhtttWseiGvPksPedllaflgevetayaqqrktetegeggkPiilhCsaGvgRtgtfcvvysairelt KGDDI-NIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGA |. | || .|. ..|. | .|. ..|...| |..| | agngiiniprvvrrlrqqRkymvqkkvilkklyeavleaa |
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| Phosphatase | PTPN2.AA | Subfamily.N_Nematode_1.PD | 35-268 | 35 | 6.3e-52 | 167.7 | In-house | 17-256 (265) | Show / Hide |
Range on Protein: 35-268 Range on HMM: 17-256/265 Sequence Identity: 35% (87 aa) RVAKFPENRN--RNRYRDVSPYDHSRVKL--QNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTD .| | |... .|||.||. |..|||| ... .||| | | . . .| .|.|| .|. .|| || |.| .|.||| ...|| .|||.|.|. kvkafkeaqeadknrykdvgcldknrvklaeeplpsdyihanyvgtptnpkrficaqaPldktiadfwymvlqekveaivmlckliekgkkkcaeyfpak D-QEMLFKETGFSVKL-LSEDVK----SYYTVHLLQLENINSG-ETRTISHFHYTTWPDFGVPESPASFLNFLFKVResgslnPDHGPAVIHCSAGIGRS . ... |||.| . . | .|| . ... .|| .| .||.. |...| ||| |||. .|..| .|| ...|| |.||||||||.| egeklefkekgqkitvenslgvkkleedeevikvtvlevegaGektrkvthyqWtdWPdrGvPpadlaalelleavr------gskgPivvhCsaGiGrt GTFSLVDTCLVLMEKGDDIN-IKQVLLNMRKYRMGLIQTPDQLRFS | .. | . .|. |. ..... ..|. | ||| | | Gtivaieyildkllegkqiedmeklvkkireqrnysiqtdaqylfv |
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| Phosphatase | PTPN2.AA | Subfamily.N20.PD | 36-274 | 36 | 8.8e-51 | 164.2 | In-house | 20-254 (257) | Show / Hide |
Range on Protein: 36-274 Range on HMM: 20-254/257 Sequence Identity: 36% (87 aa) VAKFPENRNRNRYRDVSPYDHSRVKLQNAeNDYINASLVDIEEAQR--SYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQE . | ||..|||||. ||| .|| | .. .|||||| . | .. || ||||| .| || || ..... . |. | .| .|| .||| .. | sgnqpsnreknryrdilpydstrvplgks-kdyinasyirivncgeeyfyiatqgpllstiddfwqmvlennsnviamitreieggiikcyhywpislkk MLfKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSlnpdHGPAVIHCSAGIGRSGTFSLVDTCL . | | | .. |. ....|. . ..| .... ....| |||.| | | ||.... |.| || |.||||||||.| | || .. pl-elkhfrvflenyqilqyfiirmfqvvekstgtshsvkqlqftkwpdhgtpasadsfikyiryarkshl----tgpmvvhcsagigrtgvflcvdvvf VLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE . | .|| ... .||. | |..|| .| .| | ..| caivkncsfnimdivaqmreqrsgmvqtkeqyhfcydivle |
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| Phosphatase | PTPN2.AA | Subfamily.N_Nematode_6.PD | 35-273 | 31 | 1.8e-47 | 153.2 | In-house | 17-249 (253) | Show / Hide |
Range on Protein: 35-273 Range on HMM: 17-249/253 Sequence Identity: 31% (74 aa) RVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTD-DQE . | ....||||... .| .|.||.. |. || |.||.| .| .| ||.|| .|. .|| |. . .. .||| .|||. |.|.| . ... eataflkfkdrnrytniqCcdagrlkladdedfyihanlvkistkprrlictqaplegtieefwkmilssgveyivmlcelvekgkeksaeylsdkvGda MLFKETGFSVKLLSEDVKSYYTVHLLQLENiNSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVREsgslnpDHGPAVIHCSAGIGRSGTFSLVDTCL . . .|. .|. . |... ...| . |.|. ||| |||.| | | .| |..|. | |.|||||.|| ||..|. . | . . | rkitklctvikigrkdidkilvrslkrivk-agdeevivkhihWanWPdhGvPdsflsalrllsvvkk------dkkPivvhCsaGvGrtGtlaliliil VLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAII ...|..| ..|. |. .|| | . . .. ealrlpdfqgvkdllvklreerfravqtevqylyalrcvl |
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| Phosphatase | PTPN2.AA | Subfamily.N_Nematode_4.PD | 41-274 | 28 | 3.9e-47 | 152.1 | In-house | 25-261 (264) | Show / Hide |
Range on Protein: 41-274 Range on HMM: 25-261/264 Sequence Identity: 28% (69 aa) ENRNRNRYRDVSPYDHSRVKLQNA--ENDYINASLVDIEeAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEmLFKE .| ..|||.|. |..|| |.| .|||| || . . . || |||||..| || ||...|...|||| .|.. |||.|.| .... | knsdknryadilcidetrvvlknrdpdndyihaswmrmP-dkfryistqGPlketlsdfwhmvytekiavvvmlcdlieegvekcaryypeksek-vvkf TGFSVKLLSEDVKSYYTVHLLQ--LENIN-SGET----RTISHFHYTTWPDFGVPESPASFLNFLFKVREsgslNPDHGPAVIHCSAGIGRSGTFSLVDT . ..|. . .. . | | . |.. . .. . |.... |.| |. .|. .... |.. .. ..| |.|||||.||. |. .| GkyritlvekkeeviadvilnslkvtntekkkdapseplvvkhvqvdwwrdqvaPldaapviklykavkk----kkkekPivvhcsaGvGrtatlvGidy CLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE . . . .|.. ... ..|. |.. .|. | | .. .|| atirirenseievldivrelramrlkavqshlqflfllvvlie |
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| Phosphatase | PTPN2.AA | Subfamily.R_Nematode_2.PD | 42-270 | 33 | 1.5e-45 | 146.8 | In-house | 29-254 (261) | Show / Hide |
Range on Protein: 42-270 Range on HMM: 29-254/261 Sequence Identity: 33% (77 aa) NRNRNRYRDVSPYDHSRVKLQ-NAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKEtG .....|| || ....|. . . | | |. .. .. .| ||||| ||. || || |.| .||| . |||| ||..|.|.. .. | . pkdkhRypdvPCkpetavevivdgkrvpihanwvptagnpkrfiatqgPlentsedfWamviqekvekivmlcqkvekekekceeYfpletsqkldlg-r FSVKLLSEDVKSYY--TVHLLQLENINS-GETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESgslnpdHGPAVIHCSAGIGRSGTFSLVDTCLVLME ||.| .|.. .. |. |. . .|||. |. |. ||| |||.| | . | |..|. | |.||||||||...| .. .|. ..|. fsiktvsaekilkdeiekrtlkvedstgkfatrtvthyqyeeWpdrgvPkshaelfeLlelvkks------ekPivvhCsaGiGRtmafigteylareve KGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYM ... | ..|..|. ||| || . . adptieltealkelrehRwkgiqtesqlywltl |
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| Phosphatase | PTPN2.AA | Subfamily.R_Nematode_3.PD | 38-275 | 27 | 3.7e-44 | 142.3 | In-house | 19-265 (267) | Show / Hide |
Range on Protein: 38-275 Range on HMM: 19-265/267 Sequence Identity: 27% (70 aa) KFPENRNRNRYRDVSPYDHSRVKLQN----AENDYINASLVDIEEAqRSYILTQGPL--------PNTCCHFWLMVWQQKTKAVVMLNRIVE---KESVK .. .. . .|. .|. . ..||.|.. ..|.|.|..| ... . ||||.|. .|. || |. |.|...|||| .|| .|. | slskkvsedrrvevpllektrvvLkgygkrfkddfihAnvvecpng-lklIltqsPqkkdkekkkkstieKfwwmieqekveqvvmlcdfveedgeeeek CAQYWPTDDQEMLfKETGFSVKL--LSEDVKSYYTVHLLQLeNINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSlnpdhgPAVIHCSAGI |..|.|.. .. | | |.||| ..... |.. ... ... |..| .|. |.. ..||.| ..|. . .|..| . |.|.|||.|| cseYypekvdgel-kfegvsvkctdikkelsedvekrtlvv-tfekkkeftvthllykgWkelnapeepkealelikfvekskt------pvvVHCsdGi GRSGTFSLVDTCLVLMEKGD-DINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEG .||.|. .. |. | . .... ... ..|| | | |||. .| |. .|... sRsatlaaielgyqliikskgkldllslikelrkqRagaiqtelelafvilgilkl |
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| Phosphatase | PTPN2.AA | Subfamily.RC.PD | 64-274 | 28 | 7.8e-44 | 141.3 | In-house | 71-285 (288) | Show / Hide |
Range on Protein: 64-274 Range on HMM: 71-285/288 Sequence Identity: 28% (62 aa) AENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWptDDQEMLFKEtgFSVKLLSEDVKSYYTVHLLQLEN . .||||| .| . || .|||| .| || |....|.| .||| .. | . |||.|| .. . . . |.| .| | |...|.| | egskyinasfidsykkpekyiaaqGplketvddfwrmiferkvkvivmltelkeGdrekcaeyw--eeGkrayGd--vevdlkdtdkssdyilrklelvn INSGETRTISHFHYTTWPDFGVPESPASFLNFL--------FKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYR ..|.. .. ||.|.. ..|| | .|... | . . | .| ..||..| .|.|.| ... | .| . ... ||. ..|| | kkrkdsrevtqiqytswsveqlpeepkellkliqvvkqklpqkrsseafknfkstpllvhcrdGsqrtGifiallallesleaeekvdvfqvvkklrkar MGLIQTPDQLRFSYMAIIE ..... .| . | ...| plmvsveeqyillydvlve |
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| Phosphatase | PTPN2.AA | Subfamily.N_Nematode_5.PD | 35-273 | 27 | 2.4e-43 | 139.5 | In-house | 18-254 (258) | Show / Hide |
Range on Protein: 35-273 Range on HMM: 18-254/258 Sequence Identity: 27% (66 aa) RVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCaQYWP-TDDQE . .| .| ..||. || .|..||||.. ...||||| ..........|||| |||.| || || |.| ..||.| . |.. .. ...| . .. . tckafeknlkknrskdvkilDetrVkltdeddsYinaskiklddlekkliltQlPlpdteedFWrmvyqekitsvvllvedeelketav-sffpletgdy MLFKETGFSVKLLSEDVKS--YYTVHLLQLENINSgetRTISHFHYTTWPDFGVPESPASFLNflFKVRESGSLNPDH-GPAVIHCSAGIGRSGTFSLVD ... .. .. . ||| .| .. .| ... |.|||.. ||.. . .. .... | . .. |.|.....|.||.||| |... lnlgkmfinnrkvevkedekkeytvevlpegcses---vfakvyhlttWkkkkvPdkvkkvik--raiekvlskkqgknapvvvvsdlGlgRagtfllls TCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAII ...| .||...| ..|. |.| ... .| . |.|.. vaieqlnngkepnideilkkirsqRpgavesliqyasvyaavl |
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| Phosphatase | PTPN2.AA | PTPc_motif | 171-274 | 40 | 2e-40 | 141.56 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 171-274 Range on HMM: 1-92/92 Sequence Identity: 40% (44 aa) TISHFHYTTWPDF-----GVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQL |. |.|||.|||. |||| |.| |. .||. | |.|||||.||.||| ..|... . ..|.|.. |||.|.|..|| .| TVHHYHYTNWPDHVEKDSGVPE--DSILEFIRHVRK---------PIVVHCSAGCGRTGTFCAIDMMMQQ------VDIFQTVKEMRKQRPGMVQTEEQY RFSYMAIIE .| |..|.| IFCYRCILE |
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| Phosphatase | PTPN2.AA | Subfamily.N_Nematode_egg.PD | 7-269 | 24 | 3.6e-24 | 76.9 | In-house | 4-249 (257) | Show / Hide |
Range on Protein: 7-269
Range on HMM: 4-249/257
Sequence Identity: 24% (64 aa)
REFEELDTQRrwqplyleirnesHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNA----ENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVW
|.|| |. .. . . | ..... | . | . |||||. .|.| | |. . .||.| || || || ||.
rrfeilersv-------------deislttaasdnylekarskrvhckessrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvedfwrmvf
QQKTKAVVMLNRIVekESVKCAQYWPTDDQEMLFK-ETGFSVKLLSEDVKS--YYTVHLLQLENINsGETRTISHFHYtTWPDFGVPESPasfLNFLFKV
|.| . .|||. . || .| ||| ..| | .. .. | | |. ..| |.|. | . . |. . . . || |. | |.|.
qekvqyivmltsak--eserceyywpkaeseslvtvpGslrienlkvdskadplfrvtklklvGgd-deelflehwqg-dvnylsdvysp---lrvlrkl
RESGSlnpdhgPAVIHCSAGIGRSGTFSLVDTCLVLMEKGD--DINIKQVLLNMRKYRMGLIQTPDQLRFSY
|.|... |. ...|. ... |. . .|... .|. | .... . | |
rnlsk------pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvy
|
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| Phosphatase | PTPN2.AA | Subfamily.N_Fungi_PTP1.PD | 42-130 | 35 | 2.1e-22 | 70.8 | In-house | 45-151 (343) | Show / Hide |
Range on Protein: 42-130 Range on HMM: 45-151/343 Sequence Identity: 35% (36 aa) NRNRNRYRDVSPYDHSRVKLQ------------NAENDYINASLVDIE----EA--QRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKC .|||... ||.||||||. ||||||. . .. | . || ||.|||.| |. .. . | |...|. || . || .|| lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc AQYWPTD . yrYWqeg |
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| Phosphatase | PTPN2.AA | Subfamily.N_Nematode_eak.PD | 35-206 | 30 | 2.5e-22 | 70.8 | In-house | 19-189 (281) | Show / Hide |
Range on Protein: 35-206 Range on HMM: 19-189/281 Sequence Identity: 30% (51 aa) RVAKFPENRNRNRYRDVSPYDHSRVKLQNA---ENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDD ||.. |. |||| .. |.|. |.| .. .. ||||||.. | | |||| . . || || .||. |.|.|||.. | .|.| . ... rvtarleavnrnrvvkivpqdrylvrltssqlnrdGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledveekleksdkyfpdkt QEMLFKETGFSVKllSEDVKSYyTVHLLQLENINSGETRTISHFHYTTWPDFGVPESpASFLNFLFKVRESGSLN . | . || .. .|. || . |... | .. .| || ...| | |. evlkyGildverk--eyavkrn-iletrllilrkGnethrvlhykvfGwtettlpky-edflalrkvmkevGvll |
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| Phosphatase | PTPN2.AA | Subfamily.N_Fungi_PTP1.PD | 149-272 | 22 | 3.5e-12 | 37.2 | In-house | 190-338 (343) | Show / Hide |
Range on Protein: 149-272 Range on HMM: 190-338/343 Sequence Identity: 22% (34 aa) DVKSYYTVHLLQLENIN--SGETRTISHFHYTTWPDFGVPESPASFLNFLF--------KVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLV---- ... ..... .| .. .| .. .... |.| .. | |.|. | . || . | | ..|||||.||||. .| | ksddndlnnnndltpvtaavsepyevyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfei ---LMEKGDDI--------NIKQVLLNMRKYRMGLIQTPDQLRFSYMAI | .. . |.......|| |. ..|. || | | |. lenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeal |
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| Phosphatase | PTPN2.AA | Family.DSP.PD | 62-261 | 21 | 2.5e-08 | 24.9 | In-house | 79-232 (387) | Show / Hide |
Range on Protein: 62-261
Range on HMM: 79-232/387
Sequence Identity: 21% (33 aa)
QNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKtKAVVMLNRIVEKESVKCAqywptddqemlfketgfS------Vkllsedvksyyt
| . | |. . .| .. . . .|. . .| .| ... | . |.. . |.... | . .. ..|...| | ... . |.|
qaelngfidvhtfdldtydhfervengkpseilphlylgsllaa-knlewlkelgvtkivnlt-----------------ddkpqftk------------
vhllqleninsgeTRTISHFHYtTWPDFGVPESPASFLNFLFkVRESGSlNpDHGPAVIHCSAGIGRSGTfslvDTCLVLMEKgDDINIKQVLLNMRKYR
. ..| ...|| ||.||||| .. ||.. ... ..| .|. | | |.
-------------elgikylri-pidDhnapplenlfekaid-fieegn-d-skgvVlVHCkaGkgRsgt----liiaYlmks-egltleealdwvrskR
MGLIQT
pgvitp
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| Phosphatase | PTPN2.AA | Subfamily.PTPDC1.PD | 175-267 | 26 | 1.1e-07 | 22.9 | In-house | 137-219 (229) | Show / Hide |
Range on Protein: 175-267 Range on HMM: 137-219/229 Sequence Identity: 26% (25 aa) FHYTTWPDFGVPeSPASFLNfLFKVRESGSlnpDHGPAVIHCSAGIGRSGtfSLVDTCLVLMEkgdDINIKQVLLNMRKYRMGLIQTPDQLRF |. ...|.||. | . |. . || .. .| .|| || || | .|. . || . ... .. . .|. | ||| .|... fynfglkDygva-sleriLd-ivkvvdfal---eegkiavHCHAGlGRtG--vliacylvyak---rltaeeaiklvrskrpksiqtreqvel |
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| Phosphatase | PTPN2.AA | Subfamily.RC.PD | 32-62 | 45 | 1.3e-06 | 19.1 | In-house | 16-46 (288) | Show / Hide |
Range on Protein: 32-62 Range on HMM: 16-46/288 Sequence Identity: 45% (14 aa) YPHRVAKFPENRNRNRYRDVSPYDHSRVKLQ .. ..|. .||...||| || |||. ||.|. rtikiarkeenksknrysdvlpydynrvelk |
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| Phosphatase | PTPN2.AA | Subfamily.DSP23.PD | 206-264 | 30 | 2.4e-06 | 19.0 | In-house | 63-116 (128) | Show / Hide |
Range on Protein: 206-264 Range on HMM: 63-116/128 Sequence Identity: 30% (18 aa) NPDHGPAVIHCSAGIGRSGTfsLVdTCLVLMEKGddINIKQVLLNMRKYRMGLIQTPDQ . ... .|| |.||.|| |. .| .. |.| . .. . ..|| | | |.| .| ekkeeavgvhcalGlGrtGt--ll-acylvkeeg--laaddaiaevrkrrkGsietveq |
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