Gene PTPN12
PTPN12
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of PTPN12.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | PTPN12.AA | Subfamily.N12.PD | 27-294 | 60 | 7.79999999999e-137 | 446.2 | In-house | 1-269 (270) | Show / Hide |
Range on Protein: 27-294 Range on HMM: 1-269/270 Sequence Identity: 60% (164 aa) NFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNV .||..|..|..||.||..||.|.|..|||||||||||||||||.|.|||.|. .. ...||||||||||||.|...|.|.||||..|. ||||||||.|| efakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdyinanfikgvegkleyiaaqgPLpktlddfWrmiweknv VIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQART-DYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDV |.||||||.|.|.|||||||| .||....|..|....|.|.| . |..|||| .|.|.|||..||||| .||||.|||| .|.|..|.|.|..||.||. eivvmaCrevelgkkkCeryWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhytaWPDhgvPssaksllelielvrelqeseda PICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF |...|||||.||||.|.||||...||||.|||||..||.|..|.|.||...||||||||||..|.|.|. PlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv |
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| Phosphatase | PTPN12.AA | PTPc | 27-295 | 36 | 7.4e-129 | 435.3 | SMART | 1-308 (308) | Show / Hide |
Range on Protein: 27-295 Range on HMM: 1-308/308 Sequence Identity: 36% (115 aa) NFARDFMRLRRLSTKYRTEKIY----PTATGEKEENV--KKNRYK-DILPFDHSRVKLTLKTPS----QDSDYINANFIKGVYGPKAYVATQGPLANTVI |.. |.||.|. .. ... .| .. .....||. .||||| ||...||.||||. . ..|||||||.|.| ..||.| .||||| .|. GFWEEFERLQRMTPWDLMS-NYDPCCSCTCACWPENREMDKNRYKCDIPCYDHTRVKLKPPPGESHCYEGSDYINANYIDGYWRPKRYICTQGPLPHTIE DFWRMIWEYNVVIIVMACREFEM--------GRKKCERYWPLYGEDPITFAPFKISCEDEQART-DYFIRTLLLEFQN----------ESRRLYQFHYVN |||||.|.... |||| |...|. ||.||..|||. | |. ... |..|. || .||. ..... |.| ....|| | DFWRMVWQQKCHIIVMLCNCMEKCTENRDQNGREKCHQYWPDE---PMTYGHITVTCKSEEKCPDDYTMRTFEVTNTGCNCKYSMACSETRTVTHYHYTN WPDHDVPSSFDSILDMISLMRKYQEHE-------------------DVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAV ||||.||.| ||.||.| ..|..|.|. . ||..||||||||||..||||. ...... ...|.....||.||. .| WPDHGVPESPDSFLDFIRQVRHWQSHSPNMYMNMVSSNSKYHHTCPTGPIVVHCSAGCGRTGTFCAIDIMCQQIEN------VDIFQIVKMMRNQRPGMV QTKEQYELVHRAIAQLFE ||.||| ..|.|..... QTEEQYIFCYRCILEYIK |
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| Phosphatase | PTPN12.AA | Y_phosphatase | 58-292 | 44 | 1.1e-120 | 412.03 | Pfam | 1-243 (243) | Show / Hide |
Range on Protein: 58-292 Range on HMM: 1-243/243 Sequence Identity: 44% (109 aa) NVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYG-PKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGR-KK-CERYWPL-YGED | .|||||||...||.||||. . .||||||||.|.|.|. |||| .||||. .|. |||||.|.... .||| |...|||| .| |..|||. .. NKEKNRYKDIPCYDHTRVKLQPIPGDEDSDYINANYIDGPYWNPKAYICTQGPMPHTIEDFWRMVWQQKCTCIVMLCNCMEMGRDEKTCHQYWPDNKEGQ PITFAPFKISCEDEQARTDYFIRTLLLEFQN----ESRRLYQFHYVNWPDHDVPSS-FDSILDMISLMRKYQE-HEDV--PICIHCSAGCGRTGAICAID |.|. .|.. |..|. .|| .||. ... . |.|.....|| |||||.||.| ..|.||.| .||.|. ... ||..||||||||||. |||| PMTYGDFQVTCVSEEHCPDYTVRTFEVTN-GDQKQETRTVTHYHYTNWPDHGVPESQPKSMLDFIRQVRKWQPNPDHGCPPIVVHCSAGCGRTGTFCAID YTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ . . ........ ..|.....||.||. .||| |||. ....|.. IMCQQMEHEGTV---DIFQIVKHMRNQRPGMVQTEEQYIFCYQCILE |
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| Phosphatase | PTPN12.AA | Subfamily.R_Sponge_2.PD | 43-293 | 40 | 1.3e-79 | 258.8 | In-house | 10-260 (262) | Show / Hide |
Range on Protein: 43-293 Range on HMM: 10-260/262 Sequence Identity: 40% (103 aa) RTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLkTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKK ..|. . .....||| |||.|.|||.|.|||.|. . |.|||||||.|. | .|||.|||||| .|| |||||.|||.| .||| . | |..| eketefslsiaklkenvgKnRfkeilpydmsRvrLrt-dgskdsDYinAsfvdgykrrkayiatqgPlketveDfWRmvweykvstivmltnleengkek CERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQN---ESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQE-HEDVPICIHCSAGCGRT |..||| .. .. ||. ..|....|| ||.| | .. ... . |||.|.||.|.||.. |.|..|. ... |. .....| ..||.| ||| cakYWPekvdeeveygkfkvtlkeeekladyiirklklskekssegeadvtqfhfvaWpehevPkdatsllelikrvlraqkksgnkaitvvCsdgvgrt GAICAIDYTWNLLkagKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQL |. .|.| . | |. || .||......||.| ||...||. .| |.... Gtfialdsvlerl---kaeeeidvfevlktlrtkriglvqdaaqYvfihdalley |
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| Phosphatase | PTPN12.AA | Subfamily.RB.PD | 47-294 | 41 | 8.8e-79 | 256.0 | In-house | 15-260 (261) | Show / Hide |
Range on Protein: 47-294 Range on HMM: 15-260/261 Sequence Identity: 41% (102 aa) IYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERY .... |...| .|||.. |||.|||||||. ..|.||||||.|.| |. |.|||||| .|| |||||.|| .. |||| . .| |..|||.||| dqavkaaeeavnraknrftnilpydhsrvkLaalkdesdtdyinanyipgynspreyiatqGPlpetvddfWrmvwekkssiivmltqlvEkgkekceeY WPLyGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHE--DVPICIHCSAGCGRTGAICAI |.|... |.. |. ... ||.. .| ..|.|.. |.|.. ||||.||.. ...||.. .|.. |.. . || .||||| ||||. |.| WPa-deepvlyGdikvtllaekeldewvirefkiekgkekrkvrqyhftsWpdhgvPektktlldfvrtvreaiekkaskkPivvHCsaGvGRtGtfial DytwNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF .||.| . . .|| .. |.|..| . |||..|| ..|.....|. d---rllqaieendyvdvfgvvaelReeRnllvqtekqyifiheclldll |
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| Phosphatase | PTPN12.AA | Subfamily.R_Anemone_2.PD | 52-292 | 40 | 7.4e-77 | 249.8 | In-house | 21-259 (262) | Show / Hide |
Range on Protein: 52-292 Range on HMM: 21-259/262 Sequence Identity: 40% (98 aa) TGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPlyG . .. | .|||| .||..|..||||. .. ...|||||||.| | |||.|||.||..|. |||||.|| | .||| .|| |..|..|||| .. salepvnkaknryanilaydktrvklqmlegeegsdyinanyidGyrrkkayiatqaPlpetiedfWrmvWeqnsavivmltqeeergkakvhryWP--s EDPITFAPFKISCEDEQARTDYFIRTLLLEFQ--NESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQ-EHEDVPICIHCSAGCGRTGAICAIDYTW ..... .. ..| .|| .|.. .. . .|.| . |||| .|||..||.| |.||.. ..|.| |.. || .||||| |||| .|.| . kgsrsygklvvelkeevelsdyvlrsfkvkrteeeeerqvrqfhytsWpdegvpesgaslldlvrqvekaqqesgagpivvhcsaGvGrtGvfiavdill NLLKAGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ .|| .. .||. ....|.|| ||||.|||... .. . erikaeal---vdvfqtvkqlreqrnlmvqtkdqyefiydvlle |
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| Phosphatase | PTPN12.AA | Subfamily.N_Choan_1.PD | 51-293 | 37 | 2.1e-73 | 238.4 | In-house | 19-260 (262) | Show / Hide |
Range on Protein: 51-293 Range on HMM: 19-260/262 Sequence Identity: 37% (90 aa) ATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPlY ...|||.||||..| .|..|||.| .. ....|||||||..|. |.|.|.|||||. ... .||.|.||..|..||| || ||. || |||| .. taskadenvlknrysnivayDatrvkvtpneenkntDyinanfvpgykgekeyiatqgPvPaslvsfWqmvweqkvsaivmvtreieagklkChryWP-d GEDPITFAPFKISCEDEQARTDYFIRTLLL-EFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHED-VPICIHCSAGCGRTGAICAIDYTW .... .... . |.... | |.. | . ..|.|.. |..|..|||| ||.. .|. . ..|......|..|||||| ||||. |.| . .. enselklgdvtvkslseeekktyierkfkleresgetreveqlaytaWPdhGvPattkellefrkavlkatkkktkaplvihCsaGvGrtGtyialDrlv NLLKagKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQL . |. .| ....|.| .| ||| ||| |..|. . kave--ekaealdvkavvaelrkernlmvqtlvqyefvykavlda |
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| Phosphatase | PTPN12.AA | Subfamily.N6.PD | 40-293 | 37 | 5.6e-73 | 237.2 | In-house | 22-293 (295) | Show / Hide |
Range on Protein: 40-293 Range on HMM: 22-293/295 Sequence Identity: 37% (102 aa) TKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLK-TPSQDSDYINANFI--------KGVYG--P---KAYVATQGPLANTVIDFWRMIWEYN .|. .|| | ||| || .|||||.||||||.||.|. . . ..|||||||.| .| | |.||||.| .|| |||||.|. | qkqeseklysrkegekienkeknryknilPfDhtrvilkdgepsvpgsdYiNanyirlpkaskssgenveseehqkryiatqgcLkdtvsdFWrmvwqen VVIIVMACREFEMGRKKCERYWPLYGEDPItFAPFKISCEDEQARTDYFIRTLLL---EFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEH .|||. .| | |..|| |||| ... . .... .|.. .|| .|.... ....|.|...|.|. .||||.||.. .|.... ..| ||. srvivmttkevergknkCarYWPdeetkke-tGvitvtsisEkstadYtlRefsvshkdkdkeareifqyhfkaWPdhgvpkdpgvvlnfledvnkkqee --EDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQL . ||..|||||.||||.. || .... .. . .. . |...|.|| |||..||. | .|.... lekagpivvhcsaGiGrtGtfividivlkiieqsgldvdidisksikdvrsqrsglvqteaqykfvykavqfy |
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| Phosphatase | PTPN12.AA | Subfamily.R_Anemone_1.PD | 44-292 | 37 | 1.1e-72 | 236.2 | In-house | 11-255 (258) | Show / Hide |
Range on Protein: 44-292 Range on HMM: 11-255/258 Sequence Identity: 37% (94 aa) TEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKC ..| . ...|.|| |||||.||...||||| |. .. ..|||||| .... . .|..|||.|| .|| |||||.|.... .||| |. ||| eikeeekevarkaenkkknryadivaldhsRvvLeklsndeesdYinasylrasdktrafiatqapleetvedFWrmvwqekigviVmLtnliegekkkc ERYWPLygeDPITFAPFKISCEDEQARTDYFIRTLLLEF--QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAI ..||| . ... ...| . ... .|| ||||.|. ..|.| ..|.|...|||. ||. ..|.. . ..| ..... |. .||||| ||||| hqYwPd---stekygelrvslrkkevfadyiirtlvlskkketeerevvqyhftvWpdkgvPqyatavLglrrkvqksslagarpvvvhCsaGvgRtGaf CAIDytwNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ ..|| .|. | . ..|| .. .|..| .||||||| .|.|. . lvid---amleqakkekvvDifnyvkairedrphmvqtkeqyvfihlavle |
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| Phosphatase | PTPN12.AA | Subfamily.N3.PD | 42-294 | 38 | 3.3e-71 | 230.9 | In-house | 10-260 (261) | Show / Hide |
Range on Protein: 42-294 Range on HMM: 10-260/261 Sequence Identity: 38% (99 aa) YRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTlktpSQDSDYINANFIK----GVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFE || . . . | ||..||||.||||.|. ||||. ....||||||... . . |.|||||||.|. |||.|.|| .. .|||| ||.| yrkkpglaisaarkpenlaknryrdilpydatrvklk----esetdyinanyvnmeipstglvnryiatqGplaktakdfWqmvweqkstlivmlttlve MGRKKCERYWPLyGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQN--ESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGC | .||| || ..|. |.. || |.... | .| |.|. .. |.|...|. |..||||.||.. ...|.... .||... .. |. .||||| |||| rGrvkChqyWPe-tedelefgefsvrcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGi GRTGAICAIDYTWNLLKAgkiPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF . ... . |. | |.... .....|| || . |||..||..| || ... grtGvlilletalaliea---aepvypldivrtmrdqramlvqtvsqykfvCeailkay |
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| Phosphatase | PTPN12.AA | Subfamily.N13.PD | 49-293 | 37 | 7.2e-71 | 230.1 | In-house | 17-257 (259) | Show / Hide |
Range on Protein: 49-293 Range on HMM: 17-257/259 Sequence Identity: 37% (93 aa) PTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPsqdsdYINANFIKGVYGPKA--YVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERY . .|.|.|| .||||...||.|..|||| ... ||||..|| | . |.|.|||| .|| |||.|.|| .. .|.| | | |. ||.||| tcevgkkkenkdknryrnvlPydetrvklgdegg-----yinaslikvpvgedeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchry WPLYGEDPITFAP-FKISCEDEQARTDYFIRTLLLEFQ--NESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEhEDVPICIHCSAGCGRTGAICA | ..... .... .. | . .. .|.| .. . .|||.. ....|.||||.|||| .... ... .|. |. . || .||||| ||.|.. .| wPerknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaelvqfvaevrllqt-dagPivvhcsaGiGrsGvlit IDYTWNLLKAGKipeEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQL | .|.. | ||.| ......| ||.. ||||.|| .|..|| .. idvvlglierdk---efdvkeivrklreqrqgvvqtkdqyifvykailev |
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| Phosphatase | PTPN12.AA | Subfamily.N9.PD | 54-291 | 39 | 4.3e-70 | 227.7 | In-house | 22-271 (275) | Show / Hide |
Range on Protein: 54-291 Range on HMM: 22-271/275 Sequence Identity: 39% (100 aa) EKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGED .. |..||||.|.| .|..||||. . .. ||||||||..| .||..|||||| .|| |||||.|| .|..|||. | |.|| || .|||| |. klranleknrytdvlcydetrvklakldedeasdyinanfvdGykqkkafiatqGplkktvsdfwrmvweqevlvivmttrvvergrlkcgqywpleees PITFAPFKISCEDEQARTDYFIRTLLLE--FQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQE-------------HEDVPICIHCSAGCGRT . |. ...| . ... || .|.| .. ..|||.. | .. |||. |||| |.||... .|..| .. || .||||| ||| saefgdlsvsnveveveedykvrvleiknvkteesrkvthfqflswPdyGvPssaaslldvlekvrekqalavkelgdeskghlsgPPivvhcsaGiGrt GAICAIDYTWNLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIA |. ...|.. . |. . .|.. .. .|||| ..||.||||. . |. Gtfitldiclarleev---gtvdvvetvkllrtqrafsiqtpeqyefcylavl |
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| Phosphatase | PTPN12.AA | Subfamily.RA.PD | 50-292 | 38 | 2.9e-69 | 224.8 | In-house | 19-263 (266) | Show / Hide |
Range on Protein: 50-292 Range on HMM: 19-263/266 Sequence Identity: 38% (96 aa) TATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPL |..|||| ||||. .|||.|.||| |. | ..|||||| ||.| . ..|.|||...|| ||||||||.. ||| | ...||.||| | lrtankeenkkknrvvqilpydfsrvilsvkeGeeesdyinasfidGyrekdkfiaaqGpkeetvedfwrmiweqksativmltelkerkeekcaqywpd YGEdpITFAPFKISCEDEQARTDYFIRTLLLE------FQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDV-PICIHCSAGCGRTGAIC .|. ... .||. || .| .|.. ...|| . |||. .||. ||.. .|... ..| |. . || .||||| ||||. ...| eGl--vtyGeirvevkdetvledytvrdflvtqlpdatrekksrlvrqfhftswpevGvpaegkGmlkllkkvkklqqqsanhpivvhcsaGvGrtGtfi AIDYTWNLLKAGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ . .|| .. .||. ....|.|| |||.||||...... . vldavlervkaerk---ldvfeavkrlrlqrpqmvqtleqyefiykvlle |
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| Phosphatase | PTPN12.AA | Subfamily.N5_RR.PD | 58-292 | 39 | 6.3e-69 | 223.7 | In-house | 23-262 (265) | Show / Hide |
Range on Protein: 58-292 Range on HMM: 23-262/265 Sequence Identity: 39% (95 aa) NVKKNRYKDILPFDHSRVKLTLKTPSQD-SDYINANFIKGV-YGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGED-- . .|||||.||| ..||| |. ...... |.|||||.||| . ||||||||||.||. ||||||.. .| .||| . |. |.||..|.| . sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntiadfWrmiyqeevqvivmltklkeanrqkcavyfPdaedyei PITFAPFKISCEDEQARTDYFIRTLLLEFQNE-SRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHED---VPICIHCSAGCGRTGAICAIDYTWN .. ..| |. | || .|.|.|..... .|... . | .||||..| . ...||.. ... .|.|. |. .||||| ||||. ||. . . serygdveikveeiverndysvrklvlkylerversvkhywytdWPdhksPddintlldlvleveesreeenaklaPvvvhcsaGiGrtGcfiaisiavr LLKAgkiPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ |.. . .|.... ..| .| |||.|||||.|||... qlre---eivvdvlkivcnlrldrGGmvqtseqyelihralcl |
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| Phosphatase | PTPN12.AA | Subfamily.R_Ecdysozoa.PD | 49-292 | 38 | 2.5e-68 | 221.5 | In-house | 18-266 (269) | Show / Hide |
Range on Protein: 49-292 Range on HMM: 18-266/269 Sequence Identity: 38% (96 aa) PTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKkCERYWP | ..||.|| ||||.|| .||. ||||. . ..|||||||.|||| | ..| |.|. .|. ||||||.| .| .|||. |. || |..||| stkvsekkenalknryedikafDktrvkLkkingkedsdyinasfikgykekkkfiaaqdPveatigDfWrmiaeqevtlivmlsnlteknrk-cakyWp LYgeDPITFAPFKISCEDEQARTDYFIRTLLLEFQN-----ESRRLYQFHYVNWP-DHDVPSSFDSILDMISLMRKYQEHE-----DVPICIHCSAGCGR | . . . . .|. .|| ||.| . .. .||.. |..| .|. | || . ..|..|. .|...... || .||||| ||.| . ie--devqygdilvklvseekhsdyiireldvskkkeesvedsrkvvqysytgWksDskvPevargllklieqvrelyklnklsgsrsPivvhCsaGvgr TGAICAIDYTWNLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ |.| .. ||| .. ..|. ....| || || |||. ..||.|. sgifvaldlllqqlkae---dkvdifetvkkLrsqrnllvqsleqyvflyralad |
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| Phosphatase | PTPN12.AA | Subfamily.N_Choan_2.PD | 54-292 | 40 | 3.7e-67 | 217.7 | In-house | 17-263 (266) | Show / Hide |
Range on Protein: 54-292 Range on HMM: 17-263/266 Sequence Identity: 40% (102 aa) EKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYG-PKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGE | | . |||.|||| ..||.| . . . |||||...|. | .|.|.|..|||..|. .||||||| .| |||. | |||||||||| . eyarnkrlnRyndiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk DPITFAPFKISC--EDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFD------SILDMISLMRKYQEHED--VPICIHCSAGCGRTGAIC . ...| ||. . |. .. | .. | || ..|.||| |.|..|||| ||.. | ..|.|. .|.... | |. .||||| |||| . | ekvkladgkikvlalseekeegyiltrlrlekkgetrrlvHfwyntWpdhgvpreedsslstdqllkmlravrrvrkeldkaePllvHcsaGvgRtGtli AIDYTWNLLKAGKipeEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ ||.. .||. | . .| ..|.|.| .| ||. |||||...|... aiDiavrlLeetk---kvdvlaiieelRkdRmalvqhpeqyellykavve |
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| Phosphatase | PTPN12.AA | Subfamily.RG.PD | 48-293 | 35 | 1e-66 | 216.5 | In-house | 17-262 (264) | Show / Hide |
Range on Protein: 48-293 Range on HMM: 17-262/264 Sequence Identity: 35% (88 aa) YPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYW .... .|||| .|||. .|.....|||||. .. ...|||||..|.| . |.|..|||||..|. |||||||| |. |||| | ||.....||| ieaesskkeenkeknReinivaversRvklsplpgkdgkDYinAsyidGyrrskeyivtqgplketiedFWrmiWehnaqiivmltdldekgrrdedvyW PLYgEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNE----SRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICA ..|... .|. ... .| .|...|. .. .|. .|.|| .|||...|.| | .. . ...| || .|.||| ||.| .|. Pkk-deplelealkvtllskeklskytvrdfvlkntkddkekervvrqyhytkWPdmgsPestlfvlifvkkeeaankeeaGPivvhdsaGvgragtyia IDytwNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQL | ||. . | ||..... .|..| |.|.||| .. |. .| ld---tllqqlekeeavnvyqvlklirakRpglvtteEqyvfiydallel |
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| Phosphatase | PTPN12.AA | Subfamily.RK.PD | 50-291 | 36 | 9.4e-66 | 213.1 | In-house | 21-263 (267) | Show / Hide |
Range on Protein: 50-291 Range on HMM: 21-263/267 Sequence Identity: 36% (89 aa) TATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSqDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACRE-FEMGRKKCERYWP .. |..| .|||..|||..|.|.|.|. .||||||..| . |.|...||||| .|| ||||.....| ||| | || || .||| cdiakkdrnreknrsmdilaydrslvflisvdgd-ssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmlteldvevgrvkClkyWP LYGEdpITFAPFKISCEDEQARTDYFIRTLLLEF----QNESRRLYQFHYVNWPDH-DVPSSFDSILDMISLMRKYQEH-EDVPICIHCSAGCGRTGAIC .| ... ..|. . . .. .|. .|.. .| |.| | . ||....||.. ||| | |.|..| . | ||. |. .| .||.||.||.|. .|| edte--vrygdikvelveaeldadlvvrifrveklargqeeirevrqfqflgWpeyrdvPvskrsllklirrvkksqeeeeeGrivvhClaGaGrsGtfi AIDYTWNLLKAGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIA | .... .. .||| ....|... |.|.|||..|. .| aidivlemieregv---vdvfnavktlrnrkvnmveteeqykfvydvil |
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| Phosphatase | PTPN12.AA | Subfamily.RN.PD | 41-292 | 39 | 7.4e-60 | 193.8 | In-house | 11-261 (264) | Show / Hide |
Range on Protein: 41-292 Range on HMM: 11-261/264 Sequence Identity: 39% (98 aa) KYRTEKIYpTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYG-PKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMG .|..|. ......|.||||||.|..||.|||||||. .. ...|||||| .| ||.||||||..|. |||.|.|| ||.||. .| | | ayeaepst-kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplsstiadfwqmvweqGvvvivnltrleeeg RKKCERYWPLYGEDpiTFAPFKISCEDEQA-RTDYFIRTLLLEF--QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCG |.|.|||| |.. .. ... | ||..|.. | ..|.| . |||.. ||...||.| |.|.. . ||| .|||.|.||||. .. vkqckrywpdeGse--vyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaG RTGAICAIDYTWNLLKAGKipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ || . |. | | .. .. .| ||. |.||.|.|.. |.|. rtGvyilidlvlerllkGv--keidiaatlehlrdqrpglvktkdqfefaltavae |
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| Phosphatase | PTPN12.AA | Subfamily.N_Nematode_1.PD | 52-294 | 34 | 1.2e-57 | 186.6 | In-house | 20-264 (265) | Show / Hide |
Range on Protein: 52-294 Range on HMM: 20-264/265 Sequence Identity: 34% (85 aa) TGEKEENVKKNRYKDILPFDHSRVKLtlKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYG . ..... .||||||. |..|||| .... |||| ||.. || .. .|.|| .|. ||| |. .| ||| |.|.|.|||. |.|. .. afkeaqeadknrykdvgcldknrvkl--aeeplpsdyihanyvgtptnpkrficaqaPldktiadfwymvlqekveaivmlckliekgkkkcaeyfpake EDPITFAPF--KISCED-----EQARTDYFIRTLLLEFQN---ESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKyqehEDVPICIHCSAGCGRTGAI ..| ||. |. ..... .|.. || . ..|.. .... .|||. ||. ..|.... .|. . .|| .||||| ||||.| | geklefkekgqkitvenslgvkkleedeevikvtvlevegaGektrkvthyqWtdWPdrGvPpadlaalelleavrg----skgPivvhCsaGiGrtGti CAIDYTWNLLKAGKIPEEFNvfNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF |.| . | .||. |. . .|....| ||. ..|| || ||| . .| vaieyildkllegkqiedme--klvkkireqrnysiqtdaqylfvhrvllnyf |
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| Phosphatase | PTPN12.AA | Subfamily.N14.PD | 50-292 | 34 | 4e-55 | 178.4 | In-house | 18-272 (275) | Show / Hide |
Range on Protein: 50-292 Range on HMM: 18-272/275 Sequence Identity: 34% (87 aa) TATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSqDSDYINANFIKGVYGPK--AYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYW . |.. .||..|||.||.||....||.|. . ...|||| || . | | |...|||| .|| |||.|.|| .| .||| .| | |..|. .|. lstaklpenaeknrfkdvlPyednrvelsptken-stgyinassikvsvggkersyivaqgPleltvqdfwqmvweqgvqlivmlteeeedgkeksfkyl PLYG--EDPITFAPFKISCEDEQARTDYFIRTLLLEF--QNESRRLYQFHYVNWPDHDVPSS---FDSILDMI-SLMRKYQEHED------VPICIHCSA | . .. ..| ||.. . . . . ..| |.. .| | .. . |..||||.||. | | |... |. || ... .|. .||||| |||| PkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsfLeevqsvrrktnsevesvkeskPPvlvhCsa GCGRTGAICAIDYTWNLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ . | . |. . || .. . .. .|.|| . ||| ||..|.... . GvGrtGvlilsdlliatlehn---eeidikkvlarLrkqrmllvqtlaqykfvykvlik |
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| Phosphatase | PTPN12.AA | Subfamily.RC.PD | 47-293 | 30 | 2.7e-54 | 175.7 | In-house | 15-286 (288) | Show / Hide |
Range on Protein: 47-293 Range on HMM: 15-286/288 Sequence Identity: 30% (84 aa) IYPTATGEKEENVKKNRYKDILPFDHSRVKL--TL-----------------KTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVV .. ..|||| .|||| |.||.|. ||.| | . |.|||| ||.. . |. |.|.|||| .|| ||||||.| | . krtikiarkeenksknrysdvlpydynrvelkhelemskesehdsdessdddidseegskyinasfidsykkpekyiaaqGplketvddfwrmiferkvk IIVMACREFEMGRKKCERYWplyGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQ--NESRRLYQFHYVNWPDHDVPSSFDSILDMISLMR-------- ||| . | |.|| .|| .| .. .. .|.. .|| .| | | . .|| ..|. | .|.....| .|..|... vivmltelkeGdrekcaeyw---eeGkrayGdvevdlkdtdkssdyilrklelvnkkrkdsrevtqiqytswsveqlpeepkellkliqvvkqklpqkrs --KYQEHEDVPICIHCSAGCGRTGAICAIDytwNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQL .... |. .||..| .||| .|.. .||.. . | .||......| .| |...||| |.. .... seafknfkstpllvhcrdGsqrtGifiall---allesleaeekvdvfqvvkklrkarplmvsveeqyillydvlvet |
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| Phosphatase | PTPN12.AA | Subfamily.N1.PD | 45-291 | 32 | 5.2e-53 | 171.6 | In-house | 15-264 (268) | Show / Hide |
Range on Protein: 45-291 Range on HMM: 15-264/268 Sequence Identity: 32% (81 aa) EKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTlktpSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCE || ..|.. ...|| ..|||.|. |.||||.|| ..| |||||.... . |. |||||..|. ||.|.|| | ..| . |.. || ekeletreaklpenrglnryrdvspydhsrikle----radvdyinaslveleeakrrYiLtqGPLphtadHFWqmvWeqnskavimLnkvvEknqikCa RYWPLYGED-PITFAP--FKISCEDEQARTDYFIRTLLLEF--QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQ--EHEDVPICIHCSAGCGR ||| |. ... .|. |. . . |.| || ..|.| ...||| .||| ||.| ..|... .|. .. .|. |||||| ||. qywpqeeeeaellleetklkvkliseerksyflvrlleLedletqetreilhfhyttwpdfgvpespaafLkfLfkvresgsLssdvgpavihCsagigr TGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIA |... .| .. . . . .. . . |.| .|. .|| .| . || sgtlslvdtclveiektgdlnavdikkvLlelRkyRvGLiqtpdqLrFsyiail |
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| Phosphatase | PTPN12.AA | Subfamily.N20.PD | 52-288 | 37 | 2.6e-50 | 162.8 | In-house | 20-250 (257) | Show / Hide |
Range on Protein: 52-288 Range on HMM: 20-250/257 Sequence Identity: 37% (90 aa) TGEKEENVKKNRYKDILPFDHSRVKLTlktpsQDSDYINANFIKGVYGPK--AYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPL .|.. | .||||.||||.| .|| | . |||||..|. | . |.|||||| .|. |||.|. | | .| | || | | || .|||. sgnqpsnreknryrdilpydstrvplg-----kskdyinasyirivncgeeyfyiatqgpllstiddfwqmvlennsnviamitreieggiikcyhywpi YGEDPITFAPFKISCEDEQARTDYFIRTLLL--EFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKyqEHEDVPICIHCSAGCGRTGAICAIDYT . |. . |.. |. | . || . . . |. . |... .|||| |.| ||.. | || | |. .||||| |||| . ..| slkkplelkhfrvflenyqilqyfiirmfqvvekstgtshsvkqlqftkwpdhgtpasadsfikyiryark--shltgpmvvhcsagigrtgvflcvdvv WNLLKAgkiPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHR . . ||..... .|| || ||||||| ... fcaivk---ncsfnimdivaqmreqrsgmvqtkeqyhfcyd |
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| Phosphatase | PTPN12.AA | Subfamily.N23.PD | 70-290 | 31 | 4.1e-50 | 162.1 | In-house | 114-345 (350) | Show / Hide |
Range on Protein: 70-290
Range on HMM: 114-345/350
Sequence Identity: 31% (73 aa)
FDHSRVKLT-LKTPSQDSDYINANFIKGVYG-PKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDE
|..|||| . |.| .||||| ..| . ..|||||.|.|. ||| |.|| . .||| .| |....||..||| ... .| ....|.....
hdpnrvklqqstqpgqqddyinatylkeltpmsPpfiatqgPiastlaDFWlmvweqqssviVmltkevegnklkcdqYwPidegetnlfgdlrvslksl
QARTDYFIRTLLLEFQNES--RRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQ---EHE------DVPICIHCSAGCGRTGAICAIDYTWNLLKAGK-
. |.| |.... | | . ..|. .|... ||.| ...|... .... . . || .||||| ||||..|. . |.||. |.
rssegwiervlhlqhndvstvrlvchlhtttWseiGvPksPedllaflgevetayaqqrktetegeggkPiilhCsaGvgRtgtfcvvysaireltagng
IPeefNVFNLIQEMRTQRHSAVQTKEQYELVHRAI
|. ......| ||. ||.|.... . .|.
ii---niprvvrrlrqqRkymvqkkvilkklyeav
|
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| Phosphatase | PTPN12.AA | Subfamily.R_Nematode_2.PD | 58-289 | 29 | 2.2e-47 | 152.9 | In-house | 29-255 (261) | Show / Hide |
Range on Protein: 58-289 Range on HMM: 29-255/261 Sequence Identity: 29% (69 aa) NVKKNRYKDILPFDHSRVKLtlKTPSQDSDyINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITF . |.||.|. ....|. ... . .. | ||.. || ..|||||| ||. ||| |. ..| ||| |. | ..|||.|.|| .. ... pkdkhRypdvPCkpetavev--ivdgkrvp-ihanwvptagnpkrfiatqgPlentsedfWamviqekvekivmlcqkvekekekceeYfpletsqkldl APFKISCEDEQA--RTDYFIRTLLLEFQNE---SRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEhedvPICIHCSAGCGRTGAICAIDYTWNLLK |.| ... . . ||| | .. .| . . | .|||..|| | . . ....|..| .. || .||||| |||.|. ...| . .. grfsiktvsaekilkdeiekrtlkvedstgkfatrtvthyqyeeWpdrgvPkshaelfeLlelvkksek----PivvhCsaGiGRtmafigteylareve AgkiPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRA | .. .. ....|.| .| ..||..|. .... a---dptieltealkelrehRwkgiqtesqlywltlg |
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| Phosphatase | PTPN12.AA | Subfamily.N_Nematode_4.PD | 40-290 | 29 | 5.8e-47 | 151.6 | In-house | 7-259 (264) | Show / Hide |
Range on Protein: 40-290 Range on HMM: 7-259/264 Sequence Identity: 29% (76 aa) TKYRTEKIYPTATGE-KEENVKKNRYKDILPFDHSRVKLTLKTPsqDSDYINANFIKGVyGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEM ... .| |. | . |.| .||||.||| |..|| | . | | ||| |.... |..||||| .|. ||| |... . ..|| | .| | rdfvkgkappnvtasaseknsdknryadilcidetrvvlknrdp--dndyihaswmrmP-dkfryistqGPlketlsdfwhmvytekiavvvmlcdliee GRKKCERYWPLYGEDPITFAPFKISCEDEQAR--TDYFIRTLLLEFQN-----ESRRLY--QFHYVNWPDHDVPSSFDSILDMISLMRKyqEHEDVPICI .||.||.| | .| ..| ... .| ...| . . |..|. ... |.|. | ...... ..| .... ||..| gvekcaryypeksekvvkfGkyritlvekkeeviadvilnslkvtntekkkdapseplvvkhvqvdwwrdqvaPldaapviklykavkk--kkkekPivv HCSAGCGRTGAICAIDYTWNLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAI |||| ||| .. |||. .. | .| ....|.|. | |||..|. . . hcsaGvGrtatlvGidyatiriren---seievldivrelramrlkavqshlqflfllvvl |
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| Phosphatase | PTPN12.AA | Subfamily.N_Nematode_6.PD | 58-290 | 32 | 5.6e-42 | 135.3 | In-house | 24-248 (253) | Show / Hide |
Range on Protein: 58-290 Range on HMM: 24-248/253 Sequence Identity: 32% (76 aa) NVKKNRYKDILPFDHSRVKLTlktpSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITF . ..|||..| .| .|.||. .. || ||..| |. .. ||.|| .|. .||.|| | ||| | | |..|. .| . | . fkdrnrytniqCcdagrlkla----ddedfyihanlvkistkprrlictqaplegtieefwkmilssgveyivmlcelvekgkeksaeylsdkvGdarki APFKISCEDEQARTDYFIRTLLLEF----QNESrRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEhedvPICIHCSAGCGRTGAICAIDYtwnLLKA . . . .. | . |. ..|. . .|. ||||| || ||.| | ..|...| .|| .||||| ||||.. | .|.| . |. tklctvikigrkdidkilvrslkrivkagdeev-ivkhihWanWPdhGvPdsflsalrllsvvkkdkk----PivvhCsaGvGrtGtlalili---ilea GKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAI .| .|. .| .| ||||. || ..| . lrlpdfqgvkdllvklreerfravqtevqylyalrcv |
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| Phosphatase | PTPN12.AA | PTPc_motif | 188-292 | 41 | 6e-42 | 146.59 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 188-292 Range on HMM: 1-92/92 Sequence Identity: 41% (46 aa) RLYQFHYVNWPDH-----DVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQ ....|| ||||| ||. ||||..| ..|| ||..|||||||||| .||||. ... ...|....|||.||. .|||.|| TVHHYHYTNWPDHVEKDSGVPE--DSILEFIRHVRK-------PIVVHCSAGCGRTGTFCAIDMMMQQ---------VDIFQTVKEMRKQRPGMVQTEEQ YELVHRAIAQ | ..|.|.. YIFCYRCILE |
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| Phosphatase | PTPN12.AA | Subfamily.N_Nematode_5.PD | 56-292 | 26 | 5.1e-39 | 125.4 | In-house | 23-255 (258) | Show / Hide |
Range on Protein: 56-292 Range on HMM: 23-255/258 Sequence Identity: 26% (64 aa) EENVKKNRYKDILPFDHSRVkltlKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCeRYWPLYGEDPI |.|.||||.||. |..|| | . .|..||||. || | .. || || .|. |||||. . ... .|..... |..... ..|| .| . eknlkknrskdvkilDetrV----kltdeddsYinaskiklddlekkliltQlPlpdteedFWrmvyqekitsvvllvedeelketav-sffpletgdyl TFAPFKISCED---EQAR-TDYFIRTLLlEFQNESRRLYQFHYVNWPDHDVPSSFDSILD-MISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNL . . | . .. . | . .| | ..|| . |. .|... ||.. .. .| . .. .. |.......|.||.| . .... . |. nlgkmfinnrkvevkedekkeytvevlp-egcsesvfakvyhlttWkkkkvPdkvkkvikraiekvlskkqgknapvvvvsdlGlgRagtflllsvaieq LKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ .| .|.|. ......|.|| ||.. || |..|... lnng---kepnideilkkirsqRpgavesliqyasvyaavld |
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| Phosphatase | PTPN12.AA | Subfamily.R_Nematode_3.PD | 45-291 | 23 | 1.5e-37 | 120.8 | In-house | 10-263 (267) | Show / Hide |
Range on Protein: 45-291 Range on HMM: 10-263/267 Sequence Identity: 23% (62 aa) EKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGpKAYVATQGPL--------ANTVIDFWRMIWEYNVVIIVMACREF .|. .... . ...|...|..... . ..||.| .|.|.||... | . ||.|. ..|. || || ...| ..|| | aklakknatslskkvsedrrvevpllektrvvLkgygkrfkddfihAnvvecpng-lklIltqsPqkkdkekkkkstieKfwwmieqekveqvvmlcdfv E---MGRKKCERYWPLYGEDPITFAPFKISC--EDEQARTDYFIRTLLLEFQNESRR-LYQFHYVNWPDHDVPSSFDSILDMISLMRKYQehedVPICIH | . .|| .|.|. . ..| ....| .... | ||| ..|... .| |... .| . ...|..| ..|.. |. .| eedgeeeekcseYypekvdgelkfegvsvkctdikkelsedvekrtlvvtfekkkeftvthllykgWkelnapeepkealelikfveksk----tpvvVH CSAGCGRTGAICAIDYTWNLLKAGKIpeEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIA ||.| .|.... ||.. .|. | .... .||.|.| ||. |.||.... | | CsdGisRsatlaaielgyqliikskg--kldllslikelrkqRagaiqtelelafvilgil |
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| Phosphatase | PTPN12.AA | Subfamily.N_Nematode_egg.PD | 31-295 | 24 | 6.2e-33 | 105.7 | In-house | 5-257 (257) | Show / Hide |
Range on Protein: 31-295 Range on HMM: 5-257/257 Sequence Identity: 24% (66 aa) DFMRLRRLStkyrteKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIV .| .| | . . | .... .| | | . . ||||| |. |.| ||..|| .. .| || ||| |||||... .| || rfeilersv------deislttaasdnylekarskrvhckessrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvedfwrmvfqekvqyiv MACREFEMgrKKCERYWPLYGEDPITF--APFKISCEDEQARTDYFIRTLLLEFQNESR-RLYQFHYvNWpDHDVPSSFDSILdmiSLMRKYQEHeDVPI | | ..|| ||| .... . ..| . . . ..| ..| | . |.|. .. | . | | | ..|| .. |. . mltsakes--erceyywpkaeseslvtvpGslrienlkvdskadplfrvtklklvGgddeelflehw-qg-dvnylsdvyspl---rvlrklrnl-skpv CIHCSAGCGRTGAICAIDYTWNLLKAGKIpEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFE .. |. ..... ||. . | | | . | . .. .| .|. .|.. .| .|.| ... .. vvqdilGvskaatlvaieiallsllrGpi-tkslvlravvflrlrrrlsvesvllylfvyrlvlffir |
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| Phosphatase | PTPN12.AA | Subfamily.N_Fungi_PTP1.PD | 58-153 | 41 | 1e-26 | 85.1 | In-house | 45-154 (343) | Show / Hide |
Range on Protein: 58-153 Range on HMM: 45-154/343 Sequence Identity: 41% (44 aa) NVKKNRYKDILPFDHSRVKLT--L------KTPSQDSDYINANFIKGV-----YGPKA-YVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKC |||||.|||..|||||| | | . .||||||..| |. |.|||.|| .|| ||...| . .|.|.. ..|....||.||| lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc ERYWPLYGED . . | yrYWqegsyd |
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| Phosphatase | PTPN12.AA | Subfamily.N_Nematode_eak.PD | 49-207 | 23 | 6.7e-19 | 59.6 | In-house | 17-174 (281) | Show / Hide |
Range on Protein: 49-207 Range on HMM: 17-174/281 Sequence Identity: 23% (37 aa) PTATGEKEENVKKNRYKDILPFDHSRVKLTLKTpSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWP ... |.|..|| .|.|.|. |.|| . |||| .. . |. | . . | ||.|. | . ||. . |.. .| ..|.| . sirvtarleavnrnrvvkivpqdrylvrltssq-lnrdGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledveekleksdkyfp LYGeDPITFAPFKISCEDE-QARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFD . . . ... . . | . | | |. ||. |.. ... | . ..| | dkt-evlkyGildverkeyavkrniletrllilrkGnethrvlhykvfGwtettlpkyed |
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| Phosphatase | PTPN12.AA | Subfamily.N_Fungi_PTP1.PD | 185-294 | 24 | 7.1e-16 | 49.5 | In-house | 211-342 (343) | Show / Hide |
Range on Protein: 185-294 Range on HMM: 211-342/343 Sequence Identity: 24% (32 aa) ESRRLYQFHYVNWPDH---DVPSSFDSILD-------MISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWN-LLKAGKIPEEFN-----------V | .||... ||.| | |. ..|. ... . || .|||||.|||| ....|. . .. ...|.. .. epyevyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDli FNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF ...|.| || | ||...|. .. |. .| siivnelrkqrismvqnldqfifiYeallfyf |
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| Phosphatase | PTPN12.AA | Subfamily.PTPDC1.PD | 191-288 | 31 | 8.2e-14 | 43.0 | In-house | 136-222 (229) | Show / Hide |
Range on Protein: 191-288 Range on HMM: 136-222/229 Sequence Identity: 31% (30 aa) QFHYVNWPDHDVPSsFDSILDMISLMRKYQehEDVPICIHCSAGCGRTGAICAIdytWnLLKAgkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHR |. . ..|..|.| ..|||.. .. |.. | .|| || |||| . | . |. | .... . |. .| .| ..||.|| |||. yfynfglkDygvas-leriLdivkvvdfal--eegkiavHCHAGlGRtGvliac---y-lvya----krltaeeaiklvrskrpksiqtreqvelvee |
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| Phosphatase | PTPN12.AA | Subfamily.DSP23.PD | 192-287 | 25 | 1.3e-10 | 32.9 | In-house | 36-121 (128) | Show / Hide |
Range on Protein: 192-287 Range on HMM: 36-121/128 Sequence Identity: 25% (24 aa) FHYVNWPDHdVPSSFDSILDMISLMRKYQEHEDvPICIHCSAGCGRTGAICAIdYtwnLLKAgkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVH .. .. ||. | . . . .. .. . ...|. .. .|| |.||||.. | | |.| |.. . | |.| .|. ...|.||..|. lrridipdf-cPPaleqvarlvriveeaekkee-avgvhcalGlGrtGtllac-y---lvke----eglaaddaiaevrkrrkGsietveqekavk |
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| Phosphatase | PTPN12.AA | Family.DSP.PD | 122-244 | 13 | 5.7e-09 | 27.1 | In-house | 129-205 (387) | Show / Hide |
Range on Protein: 122-244 Range on HMM: 129-205/387 Sequence Identity: 13% (16 aa) WEYNVVIIVMACrefemgrkkcerywplygedpitfapfkisCEDEQ--ArtdyfirtlllefqnesRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKY |..| || .. .. .| . ... ....|| .|. . |. . .. kelgvtkivnlt------------------------------ddkpqftk-----------------elgikylripidDhnapplenlfekaidfieeg QEhEDVPICIHCSAGCGRTGAICAI . . .|| || ||.| .... nd-skgvVlVHCkaGkgRsgtliia |
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| Phosphatase | PTPN12.AA | Subfamily.PTEN.PD | 182-279 | 22 | 3.4e-08 | 24.6 | In-house | 67-145 (305) | Show / Hide |
Range on Protein: 182-279 Range on HMM: 67-145/305 Sequence Identity: 22% (22 aa) FQnesrrlyqfhyvnwpDHDvPSSFDSILDMISLMRKYQEH-EDVPICIHCSAGCGRTGAICAIdYtwnLLKAGKIPEEFNVFNLIQEMRTQRHSAVQT |. || | ... . .... . |. .. .. . .|| || |||| . . | ||| |. ... . .. .|.||.. .| fd---------------Dhn-pptleLleeivedvdkwLkedksnVvavHCkaGkGRtGvmica-y---LlksgikksadealaiydekRtkdkkGVti |
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| Phosphatase | PTPN12.AA | Subfamily.PRL.PD | 207-280 | 24 | 7.9e-07 | 20.4 | In-house | 63-128 (140) | Show / Hide |
Range on Protein: 207-280 Range on HMM: 63-128/140 Sequence Identity: 24% (18 aa) DSILDMISL-MRKYQEHEDVPICIHCSAGCGRTGAICAIdytwNLLKAGKIPEEfnvfnLIQEMRTQRHSAVQTK . . . ..| ..|..|... ...|| || ||. . |. |. || .|. .. .|..|..|. .| evvdeWlellkekfkeepkstvavhcvaGlGraPvlval----alieaGmkyed-----avefirekrrgainsk |
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| Phosphatase | PTPN12.AA | Subfamily.N_Nematode_eak.PD | 212-291 | 23 | 1.8e-06 | 18.9 | In-house | 198-277 (281) | Show / Hide |
Range on Protein: 212-291 Range on HMM: 198-277/281 Sequence Identity: 23% (19 aa) MISLMRKYQEHE--DVPIcIHCSAGCGRTGAICAIDYTWNLLKaGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIA . |...||. || | .. | |.|. || .|. .|. . . | .|| ....| .| .. |. ... .. lrstlkkyihtppsfapi-iqsarGsaraGvfvvidllirlid-nkkknlysvedlilkvkskrihsvlvalqhsfiyeivl |
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