• Phosphatome.Net

Gene PTPN22

PTPN22
Species: Human
Alias: PTPN22, LYP1, LYP2, LYP, PEP, PTPN8
External Links: COSMIC , Entrez Gene
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: Classic_PTP
Subfamily: N12
Protein domain

Protein domains of PTPN22.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase PTPN22.AA Subfamily.N6.PD 22-289 38 2.9e-72 234.7 In-house 12-293 (295) Show / Hide 
Range on Protein: 22-289
Range on HMM: 12-293/295
Sequence Identity: 38% (110 aa)

EEFANEFLKLKRQStkykADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLI-TSDEDSSYINANFI--------KGVYG--P---KAYIATQGPLS
| .|| .|..|     . |.|  . .||..| .|||||.|||.| .|| |.   .|  .| |||||.|        .|         | ||||||.|..|
lgfweefeelqkqe----seklysrkegekienkeknryknilPfDhtrvilkdgepsvpgsdYiNanyirlpkaskssgenveseehqkryiatqgcLk

TTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLeFGPFSVSCEAEKRKSDYIIRTLKV---KFNSETRTIYQFHYKNWPDHDVPSSIDP
. |||||.|.    .|||. .|.| ||.|| ||| . .. .  .|  .|..  || ..||..|...|   ....|.|.|.|.|.|.||||.||..   .|
dtvsdFWrmvwqensrvivmttkevergknkCarYWPdeetkke-tGvitvtsisEkstadYtlRefsvshkdkdkeareifqyhfkaWPdhgvpkdpgv

ILELIWDVRCYQED--DSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLEL
... ||.  ||.  .. ||..|||||.|||| .  ||    ...   .  .  . . |...|.||  ||||..||. ||.||  .  
vlnfledvnkkqeelekagpivvhcsaGiGrtGtfividivlkiieqsgldvdidisksikdvrsqrsglvqteaqykfvykavqfy
Phosphatase PTPN22.AA Subfamily.N12.PD 23-291 63 1.1e-136 445.5 In-house 1-270 (270) Show / Hide 
Range on Protein: 23-291
Range on HMM: 1-270/270
Sequence Identity: 63% (171 aa)

EFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSV
|||.|| |||..|.||||.|.|.|...||..|.||||||||||||.|||||| |...|.|.||||||||||.|...|||.||||..|| ||||||||..|
efakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdyinanfikgvegkleyiaaqgPLpktlddfWrmiweknv

LIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKS-DYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSV
 |.||||.|.|.|||||||||.| ||..||||.|.|..|.||. . |..||||||....|.|..|||||..||||.||||....||||..||..||....
eivvmaCrevelgkkkCeryWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhytaWPDhgvPssaksllelielvrelqeseda

PICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK
|...|||||.||||.|.||||...|||...|||...||.|. |.|.||..||||.|||||||.||.||.|
PlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvk
Phosphatase PTPN22.AA PTPc 23-291 37 9.5e-131 441.59 SMART 1-308 (308) Show / Hide 
Range on Protein: 23-291
Range on HMM: 1-308/308
Sequence Identity: 37% (119 aa)

EFANEFLKLKRQSTKYKADKTY----PTTVAEKPKNI--KKNRYK-DILPYDYSRVELSLITSD----EDSSYINANFIKGVYGPKAYIATQGPLSTTLL
 |..|| .|.|. .. .   .|    ..|.|..|.|.  .||||| ||..||..|| |. . ..    |.| |||||.|.| ..||.||.|||||  |. 
GFWEEFERLQRMTPWDLMS-NYDPCCSCTCACWPENREMDKNRYKCDIPCYDHTRVKLKPPPGESHCYEGSDYINANYIDGYWRPKRYICTQGPLPHTIE

DFWRMIWEYSVLIIVMACMEYEM--------GKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKS-DYIIRTLKVKFNS----------ETRTIYQFHYKN
|||||.|.. . |||| |.. |.        |..||..|| .     ...| ..| |. |. .. ||..||..|..            ||||....||.|
DFWRMVWQQKCHIIVMLCNCMEKCTENRDQNGREKCHQYWPDE---PMTYGHITVTCKSEEKCPDDYTMRTFEVTNTGCNCKYSMACSETRTVTHYHYTN

WPDHDVPSSIDPILELIWDVRCYQEDD-------------------SVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLV
||||.||.| |..|..|..|| .|.                     . ||..||||||||||..||||. ......      ...| ....||.||| .|
WPDHGVPESPDSFLDFIRQVRHWQSHSPNMYMNMVSSNSKYHHTCPTGPIVVHCSAGCGRTGTFCAIDIMCQQIEN------VDIFQIVKMMRNQRPGMV

QTQEQYELVYNAVLELFK
|| |||  .| ..||..|
QTEEQYIFCYRCILEYIK
Phosphatase PTPN22.AA Y_phosphatase 54-288 46 1.1e-120 412.01 Pfam 1-243 (243) Show / Hide 
Range on Protein: 54-288
Range on HMM: 1-243/243
Sequence Identity: 46% (114 aa)

NIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYG-PKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGK-KK-CERYWAE-PGEM
| .|||||||..||..|| |. | .|||| |||||.|.|.|. |||||.||||.. |. |||||.|.. . .||| | . |||. .| |..|| .   . 
NKEKNRYKDIPCYDHTRVKLQPIPGDEDSDYINANYIDGPYWNPKAYICTQGPMPHTIEDFWRMVWQQKCTCIVMLCNCMEMGRDEKTCHQYWPDNKEGQ

QLEFGPFSVSCEAEKRKSDYIIRTLKVKFNS----ETRTIYQFHYKNWPDHDVPSS-IDPILELIWDVRCYQE-DDSV--PICIHCSAGCGRTGVICAID
 ...|.|.| |. |. ..||..||..|..      ||||....||.|||||.||.|  ...|..|. ||..|.  |.   ||..||||||||||. ||||
PMTYGDFQVTCVSEEHCPDYTVRTFEVTN-GDQKQETRTVTHYHYTNWPDHGVPESQPKSMLDFIRQVRKWQPNPDHGCPPIVVHCSAGCGRTGTFCAID

YTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE
. . ..... ..   ..| ....||.||| .||| |||. .| ..||
IMCQQMEHEGTV---DIFQIVKHMRNQRPGMVQTEEQYIFCYQCILE
Phosphatase PTPN22.AA Subfamily.RB.PD 39-290 41 3.2e-78 253.9 In-house 11-260 (261) Show / Hide 
Range on Protein: 39-290
Range on HMM: 11-260/261
Sequence Identity: 41% (103 aa)

KADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKK
| .|. ... ||...| .|||.. |||||.|||.|. . ...|. |||||.|.|   |. ||||||||..|  |||||.||  . ||||| ||.|||.||
kvgkdqavkaaeeavnraknrftnilpydhsrvkLaalkdesdtdyinanyipgynspreyiatqGPlpetvddfWrmvwekkssiivmltqlvEkgkek

CERYWAEPgEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDD--SVPICIHCSAGCGRTGV
 .  | .  .|  .|.  |||......||..|.. ..|.|.. |.|.. ||||.||.. ...|...  || . |..  . ||.||||| ||||.  |.| 
ceeYWPad-eepvlyGdikvtllaekeldewvirefkiekgkekrkvrqyhftsWpdhgvPektktlldfvrtvreaiekkaskkPivvHCsaGvGRtGt

ICAIDYTWMLLKDgiiPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELF
    ...    .   ||... |.|..| .||||..|| ......|.|.      
fialdrllqaiee---ndyvdvfgvvaelReeRnllvqtekqyifiheclldll
Phosphatase PTPN22.AA Subfamily.R_Anemone_2.PD 25-289 41 4.8e-78 253.5 In-house 3-260 (262) Show / Hide 
Range on Protein: 25-289
Range on HMM: 3-260/262
Sequence Identity: 41% (111 aa)

ANEFLKLKRQStkykaDKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLI
.|. .|.|..     ...  .. | .| | .|||| .||.|| .||.|. ....|.| |||||.| |    |||||||.||. |. |||||.||    .|
seeyerlsrse-----etsvtlksalepvnkaknryanilaydktrvklqmlegeegsdyinanyidGyrrkkayiatqaPlpetiedfWrmvWeqnsav

IVMACMEYEMGKKKCERYWaePGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFN--SETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQ-EDDSV
||   | | ||.|..|||  |..   ..|   |  . |.. |||..|..||| .  .|.|.. |||| .|||..||.|   .|.|. .|. .| | .  |
ivmltqeeergkakvhryW--PskgsrsygklvvelkeevelsdyvlrsfkvkrteeeeerqvrqfhytsWpdegvpesgaslldlvrqvekaqqesgag

PICIHCSAGCGRTGVICAIDYTWMLLKDGiipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLEL
| .||||| ||||| .|.|     .|.    .   ||  ....|.||. .|||..|||..|...||  
pivvhcsaGvGrtGvfiavdillerikae---alvdvfqtvkqlreqrnlmvqtkdqyefiydvllea
Phosphatase PTPN22.AA Subfamily.R_Sponge_2.PD 37-289 41 1.1e-76 249.0 In-house 8-260 (262) Show / Hide 
Range on Protein: 37-289
Range on HMM: 8-260/262
Sequence Identity: 41% (106 aa)

KYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLiTSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGK
. . ..   .. |....|. |||.|.||||| |||.|.  .  .|| ||||.|. |   .||||||||||..|. |||||.||| |.||| .   | ||.
sveketefslsiaklkenvgKnRfkeilpydmsRvrLrt-dgskdsDYinAsfvdgykrrkayiatqgPlketveDfWRmvweykvstivmltnleengk

KKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSE---TRTIYQFHYKNWPDHDVPSSIDPILELIWDV-RCYQEDDSVPICIHCSAGCG
||..|| |  . . |.| | |  . |.. .|||||.||.. ...   .... |||. .||.|.||..  ..|||| .| |  ... ...| ..||.| ||
ekcakYWPekvdeeveygkfkvtlkeeekladyiirklklskekssegeadvtqfhfvaWpehevPkdatsllelikrvlraqkksgnkaitvvCsdgvg

RTGVICAIDYTWMLLKDgiiPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLEL
||  .|.|   . ||     |.  ||......||.|. |||...||. ...|.||. 
rtGtfialdsvlerlka---eeeidvfevlktlrtkriglvqdaaqYvfihdalley
Phosphatase PTPN22.AA Subfamily.N_Choan_1.PD 39-289 38 8.7e-74 239.4 In-house 11-260 (262) Show / Hide 
Range on Protein: 39-289
Range on HMM: 11-260/262
Sequence Identity: 38% (98 aa)

KADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKK
....  ..| .....|..||||..|  || .||...  ...... ||||||..|. |.|.|||||||. ..| .||.|.||..| .|||   | | || |
eigvdntataskadenvlknrysnivayDatrvkvtpneenkntDyinanfvpgykgekeyiatqgPvPaslvsfWqmvweqkvsaivmvtreieagklk

CERYWAEPGEmQLEFGPFSVSCEAEKRKSDYIIRTLKV-KFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDV-RCYQEDDSVPICIHCSAGCGRTGV
| ||| .. . .|..| . |. ..|..|. || |..|. . ..|||.. |..|..|||| ||..   .||   .| .. ...  .|..|||||| ||||.
ChryWPdens-elklgdvtvkslseeekktyierkfkleresgetreveqlaytaWPdhGvPattkellefrkavlkatkkktkaplvihCsaGvGrtGt

ICAIDYTWMLLKDGIipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLEL
  |.|     ...    |. .| ....|.| .|  .|||  ||| || |||. 
yialDrlvkaveeka--ealdvkavvaelrkernlmvqtlvqyefvykavlda
Phosphatase PTPN22.AA Subfamily.N3.PD 38-290 40 5.2e-72 233.4 In-house 10-260 (261) Show / Hide 
Range on Protein: 38-290
Range on HMM: 10-260/261
Sequence Identity: 40% (104 aa)

YKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSlitsDEDSSYINANFIK----GVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYE
|.      ...| ||.|..||||.||||||  ||.|.    .... |||||...    .    . ||||||||..|  |||.|.|| .. .|||| |..|
yrkkpglaisaarkpenlaknryrdilpydatrvklk----esetdyinanyvnmeipstglvnryiatqGplaktakdfWqmvweqkstlivmlttlve

MGKKKCERYWAEPGEmQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNS--ETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGC
| .|| |... .|||| ||| || |.... |..| | .| ..  | |.|.|. | .||||.||.. . .||..  || ... .. |. .||||| |||||
rGrvkChqyWPeted-elefgefsvrcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGi

GRTGVICAIDYTWMLLKdgiIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELF
. ... . .|.    . |.. .  ..|.|| || .||||..||..| .|.|...     
grtGvlilletalalie---aaepvypldivrtmrdqramlvqtvsqykfvCeailkay
Phosphatase PTPN22.AA Subfamily.R_Anemone_1.PD 31-289 38 6.9e-72 233.4 In-house 9-256 (258) Show / Hide 
Range on Protein: 31-289
Range on HMM: 9-256/258
Sequence Identity: 38% (99 aa)

LKrqstkykADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACM
||         |.  . ||.|..| |||||.||...| ||| |.  ..||.| |||| ....  . .|.||||.||..|. |||||.|.. . .|||   
lk-------eikeeekevarkaenkkknryadivaldhsRvvLeklsndeesdYinasylrasdktrafiatqapleetvedFWrmvwqekigviVmLtn

EYEMGKKKCERYWAEpgeMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFN--SETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCS
  |. ||||..|| .    . ..| ..|| . .. ..|||||||... .  .|.|...|.|. .|||. ||.    .|.|  .|.  .. .. |. .|||
liegekkkchqYwPd---stekygelrvslrkkevfadyiirtlvlskkketeerevvqyhftvWpdkgvPqyatavLglrrkvqksslagarpvvvhCs

AGCGRTGVICAIDYtwmLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLEL
|| ||||. ..||    .|.     .   .|  .. .|..|| .|||.|||  ...|||| 
aGvgRtGaflvida---mleqakkekvvDifnyvkairedrphmvqtkeqyvfihlavlea
Phosphatase PTPN22.AA Subfamily.N_Choan_2.PD 42-288 40 2e-71 231.5 In-house 9-263 (266) Show / Hide 
Range on Protein: 42-288
Range on HMM: 9-263/266
Sequence Identity: 40% (104 aa)

KTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYG-PKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCE
..  ... |  .| . |||.||||   .|| |. ...|. ..|||||...|. | .|.|||..||| ||| .|||||||  |  |||.    | |.||||
evseeaiPeyarnkrlnRyndiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCe

RYWAEPGEMQLEF--GPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSID------PILELIWDVRCYQE--DDSVPICIHCSAG
|||..  . ....  |  .|  ..|.... ||.. |... ..|||..  |.|..|||| ||.. |       .|... .||  ..  |.. |. .|||||
rYWpaepkekvkladgkikvlalseekeegyiltrlrlekkgetrrlvHfwyntWpdhgvpreedsslstdqllkmlravrrvrkeldkaePllvHcsaG

CGRTGVICAIDYTWMLLKDGiipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE
 ||||.. |||..  ||.     ..  | ..|.|.| .|. |||..|||||.|.||.|
vgRtGtliaiDiavrlLeet---kkvdvlaiieelRkdRmalvqhpeqyellykavve
Phosphatase PTPN22.AA Subfamily.R_Ecdysozoa.PD 24-289 37 4.2e-70 227.2 In-house 2-267 (269) Show / Hide 
Range on Protein: 24-289
Range on HMM: 2-267/269
Sequence Identity: 37% (102 aa)

FANEFLKLKRQStkyKADKTypTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVL
...|. ||...    . .|.  |.|.||  |  ||||.|| ..|  || |. |. .|||.||||.||||    | .|| |.|. .|. ||||||.| .| 
leeeyekLearl---eisks--tkvsekkenalknryedikafDktrvkLkkingkedsdyinasfikgykekkkfiaaqdPveatigDfWrmiaeqevt

IIVMACMEYEMGKKkCERYWAEPgeMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNS-----ETRTIYQFHYKNWP-DHDVPSSIDPILELIWDVRCYQE
.|||   . |. .| |..||..    . ..|   | .  |. .||||||.|.|  .      ..| . |..|..|. |  || .   .|.||  || ...
livmlsnlteknrk-cakyWpie--devqygdilvklvseekhsdyiireldvskkkeesvedsrkvvqysytgWksDskvPevargllklieqvrelyk

DD-----SVPICIHCSAGCGRTGVICAIDYTWMLLKdgiIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLEL
 .       || .||||| ||.|.. |.|  .  ||     .. ..|  ....|||. |||  |||. .| |...  
lnklsgsrsPivvhCsaGvgrsgifvaldlllqqlk---aedkvdifetvkkLrsqrnllvqsleqyvflyralady
Phosphatase PTPN22.AA Subfamily.N13.PD 45-290 38 1.4e-68 222.4 In-house 17-258 (259) Show / Hide 
Range on Protein: 45-290
Range on HMM: 17-258/259
Sequence Identity: 38% (97 aa)

PTTVAEKPKNIKKNRYKDILPYDYSRVELSlitsdEDSSYINANFIKGVYGPKA--YIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERY
..|..| .| .||||...|||| .||.|.     ....||||..||   | .   |||.|||| .|  |||.|.|| .. .|.|  .| | || ||.|||
tcevgkkkenkdknryrnvlPydetrvklg-----deggyinaslikvpvgedeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchry

WAEPGEMQLEFGP-FSVSCEAEKRKSDYIIRTLKVKFN--SETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEdDSVPICIHCSAGCGRTGVICA
 |  . .|     . |. .  ...... .|.|.|| .  .|.| . .... .||||.|||| ....... .||  |. |. || .||||| ||.||. .|
wPerknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaelvqfvaevrllqt-dagPivvhcsaGiGrsGvlit

IDYTWMLLKDGIipeNFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELF
|    |..      .| |  ..|..| || ..|||..|| .||.|.||.. 
idvvlglierdk---efdvkeivrklreqrqgvvqtkdqyifvykailevl
Phosphatase PTPN22.AA Subfamily.RA.PD 46-289 39 4.2e-68 220.8 In-house 19-264 (266) Show / Hide 
Range on Protein: 46-289
Range on HMM: 19-264/266
Sequence Identity: 39% (97 aa)

TTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAE
.|.|..| ||||. .|||||.||| || .   |.| |||| ||.|    . .||.|||.. |. ||||||||.    |||     | ...||.|| . | 
lrtankeenkkknrvvqilpydfsrvilsvkeGeeesdyinasfidGyrekdkfiaaqGpkeetvedfwrmiweqksativmltelkerkeekcaqywpd

PGemQLEFGPFSVSCEAEKRKSDYIIRTLKVK------FNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSV-PICIHCSAGCGRTGVIC
  . .|   |. . |.   || .| . |.       . ..| . |||...||.  ||..   .|.|.  |.  |.  .  || .||||| ||||  ...|
eG--lvtyGeirvevkdetvledytvrdflvtqlpdatrekksrlvrqfhftswpevGvpaegkGmlkllkkvkklqqqsanhpivvhcsaGvGrtGtfi

AIDYTWMLLKDgiiPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLEL
     .|     .   ||  ....|.||| .|||.||||..|...||    
vldavlervka---erkldvfeavkrlrlqrpqmvqtleqyefiykvlley
Phosphatase PTPN22.AA Subfamily.N9.PD 47-289 41 4.9e-68 220.8 In-house 19-273 (275) Show / Hide 
Range on Protein: 47-289
Range on HMM: 19-273/275
Sequence Identity: 41% (105 aa)

TVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEP
...... |..||||.|.| || .|| |. .  || | ||||||..|   .||.|||||||  |  |||||.|| .||.|||.    |.|. ||.|| .  
lasklranleknrytdvlcydetrvklakldedeasdyinanfvdGykqkkafiatqGplkktvsdfwrmvweqevlvivmttrvvergrlkcgqywple

GEMQLEFGPFSVSCEAEKRKSDYIIRTLKVK--FNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQED-------------DSVPICIHCSAGC
| . ||| .|||    . ..|| .|.|..|   ..|.|..  | .  |||. ||||   .|...  || .|               .|| .||||| |||
eessaefgdlsvsnveveveedykvrvleiknvkteesrkvthfqflswPdyGvPssaaslldvlekvrekqalavkelgdeskghlsgPPivvhcsaGi

GRTGVICAIDYTWMLLKDGiipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLEL
|  ...|..   |..    ..  |.  .. .||||   .||.||||. | ||||    
GrtGtfitldiclarleev---gtvdvvetvkllrtqrafsiqtpeqyefcylavley
Phosphatase PTPN22.AA Subfamily.RK.PD 43-289 35 6.5e-68 220.0 In-house 18-265 (267) Show / Hide 
Range on Protein: 43-289
Range on HMM: 18-265/267
Sequence Identity: 35% (91 aa)

TYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDeDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMA-CMEYEMGKKKCER
.    .| |..| .|||..|||.|| |.| |  .  | .| ||||..| .   |.|.|.|||||  |. ||||.....    |||   .. | |. || .
sedcdiakkdrnreknrsmdilaydrslvflisvdgd-ssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmlteldvevgrvkClk

YWAEPGEMQleFGPFSVSCEAEKRKSDYIIRTLKVKF----NSETRTIYQFHYKNWPDH-DVPSSIDPILELIWDVRCYQED-DSVPICIHCSAGCGRTG
|| | .|..  .|.. | .   . ..|...|...|.     ..|.|.. ||.. .||.. ||| |   .|.||  |   ||. .  .|.||.||.||.|.
yWPedtevr--ygdikvelveaeldadlvvrifrveklargqeeirevrqfqflgWpeyrdvPvskrsllklirrvkksqeeeeeGrivvhClaGaGrsG

VICAIDYTW-MLLKDGIIpenfSVFSLIREMRTQRPSLVQTQEQYELVYNAVLEL
 .|||    |. ..|..     ||  ....|.... .|.|.|||..||...||  
tfiaidivlemieregvv----dvfnavktlrnrkvnmveteeqykfvydvilea
Phosphatase PTPN22.AA Subfamily.N5_RR.PD 52-288 38 9.5e-68 219.6 In-house 21-262 (265) Show / Hide 
Range on Protein: 52-288
Range on HMM: 21-262/265
Sequence Identity: 38% (94 aa)

PKNIKKNRYKDILPYDYSRVELSLI-TSDEDSSYINANFIKGV-YGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEM
... .|||||.||| . ||| |.   ..||||||||||.|||  .  |||.||||||..|. ||||||.. .| .|||     |. ..||..|. .  ..
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntiadfWrmiyqeevqvivmltklkeanrqkcavyfPdaedy

--QLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSE-TRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDS---VPICIHCSAGCGRTGVICAIDYT
  . ..| ...  |  ... || .|.| .|. .. .|... . | .||||..| .|...|.|. .|.  .|...    |. .||||| ||||.  ||. .
eiserygdveikveeiverndysvrklvlkylerversvkhywytdWPdhksPddintlldlvleveesreeenaklaPvvvhcsaGiGrtGcfiaisia

WMLLKDGIIpenFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE
   |.. |.     |.... ..| .|  .|||.|||||...|. .
vrqlreeiv---vdvlkivcnlrldrGGmvqtseqyelihralcl
Phosphatase PTPN22.AA Subfamily.RG.PD 40-289 35 1e-66 216.3 In-house 13-262 (264) Show / Hide 
Range on Protein: 40-289
Range on HMM: 13-262/264
Sequence Identity: 35% (89 aa)

ADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKC
..|  ... ..|..| .|||. .|.... |||.|| ..  ... ||||..|.| .  |.||.||||| .|. ||||||||  . ||||     ||.....
kpkdieaesskkeenkeknReinivaversRvklsplpgkdgkDYinAsyidGyrrskeyivtqgplketiedFWrmiWehnaqiivmltdldekgrrde

ERYWAEPgEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFN----SETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTG
.|| .  .  ||.. ..|   .....|.|..|.. .| .    ...|...|.|| .|||...|.|. . |  .      ..... ||.|.||| ||.|. 
dvyWPkk-deplelealkvtllskeklskytvrdfvlkntkddkekervvrqyhytkWPdmgsPestlfvlifvkkeeaankeeaGPivvhdsaGvgrag

VICAIDytwMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLEL
.|.|    ||..    |.  |. ... .|..|| ||.|.|||  .|.|.|||  
tyiald---tllqqlekeeavnvyqvlklirakRpglvtteEqyvfiydallel
Phosphatase PTPN22.AA Subfamily.RN.PD 37-288 42 8.9e-62 199.9 In-house 11-261 (264) Show / Hide 
Range on Protein: 37-288
Range on HMM: 11-261/264
Sequence Identity: 42% (106 aa)

KYKADKTYpTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYG-PKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMG
.|.|...  ..||...||.||||.|..|||| |||.|.  .|.|.| |||| .|        ||||||||||.|. |||.|.||  | .||. .| | |.
ayeaepst-kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplsstiadfwqmvweqGvvvivnltrleeeg

KKKCERYWAEPGEMQleFGPFSVSCEAEKR-KSDYIIRTLKVK--FNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVR-CYQEdDSVPICIHCSAGC
|.||| . |.    .. . |   .|.    ||..|.. .|   .|||||. |||.  ||...||.|  ..||.   |  .|.| || .|||.|.||||| 
vkqckrywpdeGsev--yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG-rscpivvhcsdGa

GRTGVICAIDYTWMLLKDGIipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE
..||     |. |.   .  . . .  .| ||| ||.|..|.|... || |      
GrtGvyilidlvlerllkGv--keidiaatlehlrdqrpglvktkdqfefaltavae
Phosphatase PTPN22.AA Subfamily.RC.PD 43-289 35 2.3e-59 192.2 In-house 15-286 (288) Show / Hide 
Range on Protein: 43-289
Range on HMM: 15-286/288
Sequence Identity: 35% (93 aa)

TYPTTVAEKPKNIKKNRYKDILPYDYSRVEL-------------------SLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVL
..  .|.|..| .|||| |.||||| ||||                   . | |.| | |||| ||.. . |. |||.||||  |. ||||||.|  | .
krtikiarkeenksknrysdvlpydynrvelkhelemskesehdsdessdddidseegskyinasfidsykkpekyiaaqGplketvddfwrmiferkvk

IIVMACMEYEMGKKKCERYWaepGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFN--SETRTIYQFHYKNWPDHDVPSSIDPILELIW----------D
|||     |  ..|| .||   .| .  .|   |  . ... ||||.| |... .   ..|...|. | .|.....|     .|.||. ....  | |. 
vivmltelkeGdrekcaeyw---eeGkrayGdvevdlkdtdkssdyilrklelvnkkrkdsrevtqiqytswsveqlpeepkellkliqvvkqklpqkrs

VRCYQEDDSVPICIHCSAGCGRTGVICAIDytwMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLEL
.||..| .|||. .|..    ||.     |   || .....| .|| .|...||| |.|... |              
seafknfkstpllvhcrdGsqrtGifiall---allesleaeekvdvfqvvkklrkarplmvsveeqyillydvlvet
Phosphatase PTPN22.AA Subfamily.N14.PD 46-289 37 5.1e-58 187.6 In-house 18-273 (275) Show / Hide 
Range on Protein: 46-289
Range on HMM: 18-273/275
Sequence Identity: 37% (95 aa)

TTVAEKPKNIKKNRYKDILPYDYSRVELSLiTSDEDSSYINANFIKGVYGPK--AYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYW
...|. |.| .|||.||.|||. .|||||  | .... ||||  || . | |   ||..|||| .|. |||.|.||  | .|||   | | ||.|. .|.
lstaklpenaeknrfkdvlPyednrvelsp-tkenstgyinassikvsvggkersyivaqgPleltvqdfwqmvweqgvqlivmlteeeedgkeksfkyl

AEPG--EMQLEFGPFSVSCEAEKRKSDYIIRTLKVKF--NSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVR--CYQEDDSV--------PICIHCSA
 . .  . ..||| | |. .  .  . .| ..||.|.   .| ||.. . |..||||.||. ... |. . .|.  ... ...||. .||||| |||||.
PkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsfLeevqsvrrktnsevesvkeskPPvlvhCsa

GCGRTGVICAIDYTWMLLKDGiipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLEL
   |     |. .   |.  . . .. .|.|| .||||  ||..||.....         
GvGrtGvlilsdlliatlehn---eeidikkvlarLrkqrmllvqtlaqykfvykvliky
Phosphatase PTPN22.AA Subfamily.N1.PD 37-288 35 1.7e-53 173.0 In-house 11-265 (268) Show / Hide 
Range on Protein: 37-288
Range on HMM: 11-265/268
Sequence Identity: 35% (88 aa)

KYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSlitsDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGK
|   .| ..|..|..|.| ..|||.|. |||.||..|     ..|  ||||....     . || |||||. |   ||.|.||     ..|| .. ||  
keskekeletreaklpenrglnryrdvspydhsrikle----radvdyinaslveleeakrrYiLtqGPLphtadHFWqmvWeqnskavimLnkvvEknq

KKCERYWAEPGEM-QLEFGP--FSVSCEAEKRKSDYIIRTLKVKF--NSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCY--QEDDSVPICIHCSA
|| .  |  .|..    ..|   .|.||| .. |.|...   ..|||.|..||| .|||  ||.|   .|...  ||.| .|. |||||| ||.| .. .
ikCaqywpqeeeeaellleetklkvkliseerksyflvrlleLedletqetreilhfhyttwpdfgvpespaafLkfLfkvresgsLssdvgpavihCsa

GCGRTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE
|   ... .    .   .   . |.| .|  |.||..| .  | |.||           
gigrsgtlslvdtclveiektgdlnavdikkvLlelRkyRvGLiqtpdqLrFsyiaile
Phosphatase PTPN22.AA Subfamily.N_Nematode_1.PD 26-290 32 1.5e-51 166.4 In-house 4-264 (265) Show / Hide 
Range on Protein: 26-290
Range on HMM: 4-264/265
Sequence Identity: 32% (89 aa)

NEFLKLKRQSTKYkadktyPTTVAEKPKNIKKNRYKDILPYDYSRVELSliTSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLII
.|| .||. . .        ... .. .. .||||||.   | .|| |.  ..   | || ||..     || .| .|.||  |. ||| |.    |  |
defralkkfndee------kvkafkeaqeadknrykdvgcldknrvkla--eeplpsdyihanyvgtptnpkrficaqaPldktiadfwymvlqekveai

VMACMEYEMGKKKCERYWAEPGEMQLEFGPF--SVSC------EAEKRKSDYI-IRTLKVKFN-SETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCy
|| |   |.|||||. |..   . .|||      ..       .  ..... | . .|.|... ..||.. ......|||. ||.    .|||. .||  
vmlckliekgkkkcaeyfpakegeklefkekgqkitvenslgvkkleedeevikvtvlevegaGektrkvthyqWtdWPdrGvPpadlaalelleavrg-

qedDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSvfSLIREMRTQRPSLVQTQEQYELVYNAVLELF
   . .|| .||||| |||| | ||.|    | .| . |. .   |....|||   .||. ||  |.. .|. | 
---skgPivvhCsaGiGrtGtivaieyildkllegkqiedme--klvkkireqrnysiqtdaqylfvhrvllnyf
Phosphatase PTPN22.AA Subfamily.N23.PD 66-288 33 2.1e-49 159.7 In-house 114-347 (350) Show / Hide 
Range on Protein: 66-288
Range on HMM: 114-347/350
Sequence Identity: 33% (78 aa)

YDYSRVELS-LITSDEDSSYINANFIKGVYG-PKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAE
| .||.|  .    . . |||| ..| .      .||||||. .|| ||| |.||  . .|||   | |..|.||..|| .  .    ||...||.. ..
hdpnrvklqqstqpgqqddyinatylkeltpmsPpfiatqgPiastlaDFWlmvweqqssviVmltkevegnklkcdqYwPidegetnlfgdlrvslksl

KRKSDYIIRTLKVKFN--SETRTIYQFHYKNWPDHDVPSSIDPILELIWDVR-CY--QE------DDSVPICIHCSAGCGRTGVICAIDYTW--MLLKDG
  . .| |.|....|  |  |.. ..|...|... ||.| . .|... .|. .|  |       .   || .||||| ||||..|.      .  ..|||
rssegwiervlhlqhndvstvrlvchlhtttWseiGvPksPedllaflgevetayaqqrktetegeggkPiilhCsaGvgRtgtfcvvysaireltagng

IIpenfSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE
     .  ..|..| ||   ||...... .|.||||  
ii----niprvvrrlrqqRkymvqkkvilkklyeavle
Phosphatase PTPN22.AA Subfamily.N20.PD 49-290 37 3e-47 152.6 In-house 21-256 (257) Show / Hide 
Range on Protein: 49-290
Range on HMM: 21-256/257
Sequence Identity: 37% (91 aa)

AEKPKNIKKNRYKDILPYDYSRVELSlitsdEDSSYINANFIKGVYGPK--AYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEP
..| | .||||.|||||| .|| |      .   ||||..|. |   .   |||||||| .|. |||.|. |    .| |   | | |  ||.||    .
gnqpsnreknryrdilpydstrvplg-----kskdyinasyirivncgeeyfyiatqgpllstiddfwqmvlennsnviamitreieggiikcyhywpis

GEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNS--ETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRcyQEDDSVPICIHCSAGCGRTGVICAIDYTW
  ||.  | |  |  .    .||| ..|  .|   .... |... .||||  |.| | ... |   |  .   . |. .||||||||||. ..|  .  .
lkkplelkhfrvflenyqilqyfiirmfqvvekstgtshsvkqlqftkwpdhgtpasadsfikyiryar--kshltgpmvvhcsagigrtgvflcvdvvf

MLLKDGIipeNFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELF
       .| .. .. .|| ||  .|||.||| ..|. |||..   
caivknc---sfnimdivaqmreqrsgmvqtkeqyhfcydivlevl
Phosphatase PTPN22.AA Subfamily.N_Nematode_4.PD 30-290 32 1.1e-46 150.5 In-house 4-263 (264) Show / Hide 
Range on Protein: 30-290
Range on HMM: 4-263/264
Sequence Identity: 32% (87 aa)

KLKRQSTKYKADKTYPTTVAEkpKNIKKNRYKDILPYDYSRVELSliTSDEDSSYINANFIKGVyGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMAC
||.|.  | ||  .  ... |  || .||||.|||  | .|| |     | |  || |....       ||.|||||. || ||| |...  . ..|| |
kltrdfvkgkappnvtasase--knsdknryadilcidetrvvlk--nrdpdndyihaswmrmP-dkfryistqGPlketlsdfwhmvytekiavvvmlc

MEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRK--SDYIIRTLKVKFNS---ETRT----IYQFHYKNWPDHDVPSSIDPILELIWDVRCyqEDDS
   | | .||.||..|  |   .|| . .    .| .  .| |...|||       .. .    .  .... |.|.  |    |...|.  |.   .. .
dlieegvekcaryypeksekvvkfGkyritlvekkeeviadvilnslkvtntekkkdapseplvvkhvqvdwwrdqvaPldaapviklykavkk--kkke

VPICIHCSAGCGRTGVICAIDYTWMLLKDGiipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELF
 ||..||||| |||  .  |||. . ...     .  |  ..||.|. |||.. |.  ..  ..|||   
kPivvhcsaGvGrtatlvGidyatiriren---seievldivrelramrlkavqshlqflfllvvlielf
Phosphatase PTPN22.AA Subfamily.R_Nematode_2.PD 53-282 32 3.2e-45 145.7 In-house 28-252 (261) Show / Hide 
Range on Protein: 53-282
Range on HMM: 28-252/261
Sequence Identity: 32% (75 aa)

KNIKKNRYKDILPYDYSRVElslITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLE
.  |.||.|.   . ..||   . .|.  . | ||..     || .|||||||. |  ||| |.  . |  ||| |   |  |.|||.|..   . .|..
lpkdkhRypdvPCkpetave---vivdgkrvpihanwvptagnpkrfiatqgPlentsedfWamviqekvekivmlcqkvekekekceeYfpletsqkld

FGPFSVSCEAEKR--KSDYIIRTLKVKFNSE---TRTIYQFHYKNWPDHDVPSSIDPILELIWDVRcyqeDDSVPICIHCSAGCGRTGVICAIDYTWMLL
| ||.    ...  | .   |||||. ..    |||.  . |..|||..|| | . . ||.  |...  || .||||| |||. . ...|    ..    
lgrfsiktvsaekilkdeiekrtlkvedstgkfatrtvthyqyeeWpdrgvPkshaelfeLlelvk----ksekPivvhCsaGiGRtmafigteylarev

KDgiiPENFSVFSLIREMRTQRPSLVQTQEQYELV
 .. ..  ...|.| .|.  .||..|.  .     
ea---dptieltealkelrehRwkgiqtesqlywl
Phosphatase PTPN22.AA PTPc_motif 184-288 44 1.3e-41 145.51 SMART 1-92 (92) Show / Hide 
Range on Protein: 184-288
Range on HMM: 1-92/92
Sequence Identity: 44% (49 aa)

TIYQFHYKNWPDH-----DVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQ
|....|| |||||      ||.  |.|||.|. ||        ||..||||||||||..||||. ...         ...| ...|||.||| .||| ||
TVHHYHYTNWPDHVEKDSGVPE--DSILEFIRHVRK-------PIVVHCSAGCGRTGTFCAIDMMMQQ---------VDIFQTVKEMRKQRPGMVQTEEQ

YELVYNAVLE
|  .| ..||
YIFCYRCILE
Phosphatase PTPN22.AA Subfamily.N_Nematode_5.PD 52-291 29 8.1e-41 131.1 In-house 23-258 (258) Show / Hide 
Range on Protein: 52-291
Range on HMM: 23-258/258
Sequence Identity: 29% (70 aa)

PKNIKKNRYKDILPYDYSRVelslITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMqL
||.||||.||.  .| .||    . .|||.|||||. ||     | .| || ||..|  |||||. . ..  .|..... |...... .  | |.  |..
eknlkknrskdvkilDetrV----kltdeddsYinaskiklddlekkliltQlPlpdteedFWrmvyqekitsvvllvedeelketavsffpletgdy-l

EFGPFSVSCEA---EKRK-SDYIIRTLKVKfNSETRTIYQFHYKNWPDHDVPSSIDPILE-LIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWML
| . . . .   .... . | . .|  . .||   .   |...|... ||..  ....  |  |. ... |.......|.||.| . ....  . |..|.
nlgkmfinnrkvevkedekkeytvevlpeg-csesvfakvyhlttWkkkkvPdkvkkvikraiekvlskkqgknapvvvvsdlGlgRagtflllsvaieq

LKDGIIPEnfsVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK
 |.   .  .....|.|||  |..  ||  || |||. .|     
lnngkepn---ideilkkirsqRpgavesliqyasvyaavldyik
Phosphatase PTPN22.AA Subfamily.N_Nematode_6.PD 53-289 34 1.9e-39 126.9 In-house 23-251 (253) Show / Hide 
Range on Protein: 53-289
Range on HMM: 23-251/253
Sequence Identity: 34% (81 aa)

KNIKKNRYKDILPYDYSRVELsliTsDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLE
|. ..|||..|  .| .|..|   . |..  || ||..|    |. .| ||.|| .|. .||.||    |  ||| |   | ||.|. .| ..    .  
kfkdrnrytniqCcdagrlkl---a-ddedfyihanlvkistkprrlictqaplegtieefwkmilssgveyivmlcelvekgkeksaeylsdkvGdark

FGPFSVSCEAEKRKSDYIIRT-LK--VKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRcyqeDDSVPICIHCSAGCGRTGVICAIDYtwmLLKD
.. .    . .... | |.   ||  ||   |   .  .|..||||| || |..  | |.  |..|  || .||||| |||| .  |     .|.    |
itklctvikigrkdidkilvrslkrivkagdeevivkhihWanWPdhGvPdsflsalrllsvvk----kdkkPivvhCsaGvGrtGtlalili---ilea

GIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLEL
.  .| .|.  .| .|   |||. ||  ..  |||     
lrlpdfqgvkdllvklreerfravqtevqylyalrcvley
Phosphatase PTPN22.AA Subfamily.R_Nematode_3.PD 43-289 27 1.4e-37 120.8 In-house 21-265 (267) Show / Hide 
Range on Protein: 43-289
Range on HMM: 21-265/267
Sequence Identity: 27% (71 aa)

TypttvaekpKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGpKAYIATQGPL--------STTLLDFWRMIWEYSVLIIVMACMEYE-
.         |.....|..... .  .|| |    .   . .|.||...   |    | ||.|.         .|.  || ||.. | ..|| |  .|  
s---------kkvsedrrvevpllektrvvLkgygkrfkddfihAnvvecpng-lklIltqsPqkkdkekkkkstieKfwwmieqekveqvvmlcdfvee

--MGKKKCERYWAEPGEMQLEFGPFSVSC-EAEKRK-SDYIIRTLKVKFN-SETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQeddsVPICIHCS
  ...|| .|. |  . .|.|. .||.| . .| .  |   |||.|.|.  .. |.   .|| |....| . ...||||  |....     |. .|||.|
dgeeeekcseYypekvdgelkfegvsvkctdikkelsedvekrtlvvtfekkkeftvthllykgWkelnapeepkealelikfveksk----tpvvVHCs

AGCGRTGVICAIDYTWMLL--KDGiipeNFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLEL
 .|.... ||..   |.  ..|    .... ||| |.| ||.  .||....  |   .|.|  
dGisRsatlaaielgyqliikskg----kldllslikelrkqRagaiqtelelafvilgilkl
Phosphatase PTPN22.AA Subfamily.N_Nematode_egg.PD 26-290 24 1.5e-27 87.9 In-house 4-256 (257) Show / Hide 
Range on Protein: 26-290
Range on HMM: 4-256/257
Sequence Identity: 24% (66 aa)

NEFLKLKRQStkykadKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLII
..| .|.|        .  . | | .  . .| | | .   ..|||.| |        .| ||..||      .| .| |||  |||||...  |  |||
rrfeilersv------deislttaasdnylekarskrvhckessrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvedfwrmvfqekvqyi

VMACMEYEMgkKKCERYWAEPGEMQLEF--GPFSVSCEAEKRKSDYIIRTLKVKFNSETRTiyQFHYKNWP-DHDVPSSIDPILELIWDVRcyqeDDSVP
     |   ..|| ||    .  | .  | . . .   ..|.| ..|  |.|     .   .. . |  | .  | .   |...  .|    . | |. .
vmltsakes--erceyywpkaeseslvtvpGslrienlkvdskadplfrvtklklvGgdde--elflehwqgdvnylsdvysplrvlrklr----nlskp

ICIHCSAGCGRTGVICAIDYTWMLLKDGIIpENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELF
..  |. ..... ||. . . |  | |   . |   .  .| .|.  |..  .| .||  ||  .   
vvvqdilGvskaatlvaieiallsllrGpi-tkslvlravvflrlrrrlsvesvllylfvyrlvlffi
Phosphatase PTPN22.AA Subfamily.N_Fungi_PTP1.PD 54-146 40 1.2e-23 74.9 In-house 45-151 (343) Show / Hide 
Range on Protein: 54-146
Range on HMM: 45-151/343
Sequence Identity: 40% (41 aa)

NIKKNRYKDILPYDYSRVELS--------LITSDEDSSYINANFIKGV-----YGPKA-YIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKC
|||||.||||. |||.|            | . . |||||..|         |.  |||||.||  |. ||...| .  |.|..   . |.. .||.|||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

ERYWAEP
 |     
yrYWqeg
Phosphatase PTPN22.AA Subfamily.N_Fungi_PTP1.PD 179-290 35 1.5e-19 61.4 In-house 209-342 (343) Show / Hide 
Range on Protein: 179-290
Range on HMM: 209-342/343
Sequence Identity: 35% (42 aa)

NSETRTIYQFHYKNWPDH---DVPSSIDPILE----LIWDV---RCYQEDDSVPICIHCSAGCGRTGVICAIDYTWM---LLK--------DGIIPEN-F
||  ..||...|||.|      | || ..||    || |      .... | || .|||||.||||.....|.       |..    .. .. |.| || 
vsepyevyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrD

SVFSLIREMRTQRPSLVQTQEQYELVYNAVLELF
|.||. .|.  .|.|.| .|              
lisiivnelrkqrismvqnldqfifiYeallfyf
Phosphatase PTPN22.AA Subfamily.N_Nematode_eak.PD 46-201 21 2.9e-18 57.4 In-house 18-172 (281) Show / Hide 
Range on Protein: 46-201
Range on HMM: 18-172/281
Sequence Identity: 21% (33 aa)

TTVAEKPKNIKKNRYKDILPYDYSRVELSLITSdEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAE
.|... .....||  .|.|.|.  |.|.     .   ||||  ..     . || |  .  . .  ||.|. |     ||.. |.. .| ..|. . .  
irvtarleavnrnrvvkivpqdrylvrltssql-nrdGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledveekleksdkyfpd

PGeMQLEFGPFSVSCEAE-KRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSS
.|..| . | .     ... .  | |...   ||  .. ...  | . ..|      
kt-evlkyGildverkeyavkrniletrllilrkGnethrvlhykvfGwtettlpky
Phosphatase PTPN22.AA Subfamily.PTPDC1.PD 185-283 31 1.8e-11 35.1 In-house 135-221 (229) Show / Hide 
Range on Protein: 185-283
Range on HMM: 135-221/229
Sequence Identity: 31% (31 aa)

IYQFHYkNWPDHDVPsSIDPILELIWDVRCYQedDSVPICIHCSAGCGRTGVICAidyTWMLLKDGIIPENfsvfsLIREMRTQRPSLVQTQEQYELVY
|| . .  ..|..|. |.. ||...  |        . | .|| || |||||. |   .... .. . .|.      |. .| .||  .||.|| ||| 
iyfynf-glkDygva-sleriLdivkvvdfal--eegkiavHCHAGlGRtGvlia---cylvyakrltaee-----aiklvrskrpksiqtreqvelve
Phosphatase PTPN22.AA Subfamily.DSP23.PD 194-284 28 5.2e-09 27.5 In-house 42-124 (128) Show / Hide 
Range on Protein: 194-284
Range on HMM: 42-124/128
Sequence Identity: 28% (26 aa)

PDHdVPSSIDPILELIWDVRcYQEDDSVPICIHCSAGCGRTGVICAIdytWmLLKDgiipENFSVFSLIREMRTQRPSLVQTQEQYELV--YN
||.  | ... . .|.  |    |.   .. .||  |.|||| . |    . |.|     |...    | |.| .|.  ..|.|| ..||.  
pdf-cPPaleqvarlvrive-eaekkeeavgvhcalGlGrtGtllac---y-lvke----eglaaddaiaevrkrrkGsietveqekavkdye
Phosphatase PTPN22.AA Family.DSP.PD 180-285 17 7.7e-09 26.5 In-house 148-243 (387) Show / Hide 
Range on Protein: 180-285
Range on HMM: 148-243/387
Sequence Identity: 17% (18 aa)

SeTRTIYqFHYKNWPDHdVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIdytWMLLKDGIIPEnfSVFSLIREMRtqrPSLVQTQEQ-
. .  |. ..  ...||  ..... ..| . |. . ..|..  . .|| || ||.|.....   ... . |.  |    . ..|. |   |. .....  
k-elgik-ylripidDh-napplenlfekaidfieegndskgvVlVHCkaGkgRsgtliia---Ylmksegltle--ealdwvrskR---pgvitpnqgf

YELVYNA
. .    
lkqlkdl
Phosphatase PTPN22.AA Subfamily.PTEN.PD 160-270 30 1.3e-08 25.8 In-house 49-140 (305) Show / Hide 
Range on Protein: 160-270
Range on HMM: 49-140/305
Sequence Identity: 30% (33 aa)

CEAEKRKSDYIIRTLKVKFNsetrtiyqfhyknwpDHDvPSSIDPILELIWDVRCY-QEDDSVPICIHCSAGCGRTGVIC-AidytwMLLKDGIIPENFS
.. || .||.  |  .. |.               ||  | ... . |.. ||  . .||.|  . .|| || |||||.  |      ||||| ...   
argekedsdfdgrvavypfd---------------Dhn-pptleLleeivedvdkwLkedksnVvavHCkaGkGRtGvmica-----yLlksgikksade

VFSLIREMRTQRP
 ..  |.||.   
alaiydekRtkdk
Phosphatase PTPN22.AA Subfamily.PRL.PD 164-267 24 7.6e-07 20.2 In-house 23-122 (140) Show / Hide 
Range on Protein: 164-267
Range on HMM: 23-122/140
Sequence Identity: 24% (26 aa)

KRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHD--VPSS--IDPILELIWdvRCYQEDDSVPICIHCSAGCGRTGVICAIdytwMLLKDGIIPENfsVF
|..   ..|. ......|.    . . .... .|  ||..  .|  |||.   . ..|...  ...|| || ||. |. |.     |. .|..|.    .
kenvkevvrvcepsydaeklkeegievldlafddGavPpkevvdeWlellk--ekfkeepkstvavhcvaGlGraPvlval----alieaGmkyed--av

SLIREMRT
.||| |  
efirekrr
Phosphatase PTPN22.AA Subfamily.N_Nematode_eak.PD 222-289 31 1.2e-06 19.2 In-house 214-279 (281) Show / Hide 
Range on Protein: 222-289
Range on HMM: 214-279/281
Sequence Identity: 31% (21 aa)

PIcIHCSAGCGRTGVICAIDYTWMlLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLEL
|| | .. |  |.||   ||     | |. . . .||  ||  ....|   | .. |. ..|..||. 
pi-iqsarGsaraGvfvvidllir-lidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldy
Sequence
Name Sequence Type Origin Length Description Download
PTPN22.AA Protein None 807 None Fasta, JSON
PTPN22.NA RNA None 2421 None Fasta, JSON
PTPN22.AA.PD_23-291 Protein Phosphatase Domain None 269 None Fasta, JSON