Gene PTPN21
PTPN21
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of PTPN21.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| FERM | PTPN21.AA | B41 | 19-222 | 29 | 4.5e-69 | 236.7 | SMART | 1-232 (232) | Show / Hide |
Range on Protein: 19-222 Range on HMM: 1-232/232 Sequence Identity: 29% (68 aa) SKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLEL--REVTYFSLWYYNKQNQRRWVDLEKPLKKQLDK--YALEPTVYFGVVFYVPS----VSQ |. ....|....... .||.. ..|||. ...|...... || ||.|||... ..|.| |..|...|| | ...|..| | ||.| ..| SPKPRFCRVYFMDGTTLEFEVDSSTTGQDLCDHVCRHCGISPREHWYFGLWYEDPHEDRHWLDHWKTIMKQDVKWHKSEPWTLHFRVKFYPPDWHGFPNQ LQQEITRY-QYYLQLKKDILEGSIPCT-LEQAIQLAGLAVQADFGDFDQY---------ESQDFLQKFALFPVGWLQDEKV--------LEEATQKVALL ||...||| ..|||...|||.| .||. | ..||| |.||...||.|.. . | .. . ..| |....|. ..| ..... . LQEDPTRYNYFYLQCRHDILQGRHPCPHEEECLQLAALQVQIEYGDYDPEETNNKKMTKHVQKYKSYKRFLPKQWIDSIKQSFMHYQMHHKEWRKRIMEW HQKYRGLTAPDAEMLYMQEVERMD-GYGEESY |....|.| .|.. |.| ..| . .|| | . HKNHCGMTPEEAKLKYLQICQRWPPMYGVEHF |
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| FERM | PTPN21.AA | FERM_M | 107-222 | 22 | 3.2e-34 | 118.66 | Pfam | 1-171 (171) | Show / Hide |
Range on Protein: 107-222
Range on HMM: 1-171/171
Sequence Identity: 22% (38 aa)
SVSQ-LQQEITRYQYYLQLKKDILEGSIPCTLEQAIQLAGLAVQADFG-DFDQYE--SQDF-LQKF-------------------ALFP-----------
... .|.|.||.|.|||.| ||||| .||. |.|..||....|..|| |..... ..|. .... ...|
DPNRDIQDEVTRHQFYLQAKWDILEGRYPCSEEEALMLAAYQCQIEFGSDYNPPQKHKSDYMEKEWWEQQEGMEVWLRCDNEQQERYWPAHCRLASKGRT
------------------V-GWLQDEKVLEEATQKVALLHQKYRGL-TAPDAEMLYMQEVERMDGYGEESY
| |.. . ... .|... .|...||. .. .|.. |.|...| ..|| . .
MADSSYSEVSIRINPHCYVSPWYCKKMKQKQWEQRILEQHKNHRGMCSPEEAMLQYIQICQRWPMYGVHFF
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| FERM_C | PTPN21.AA | FERM_C | 226-312 | 27 | 5.4e-30 | 108.69 | Pfam | 1-99 (99) | Show / Hide |
Range on Protein: 226-312 Range on HMM: 1-99/99 Sequence Identity: 27% (27 aa) DSQGSD-ISIGACLEGIFVK--HKNGRH--PVVFRWHDIANMSHNKSFFALEL-------ANKEETIQFQTEDMETAKYIWRLCVARHKFYRLNQCNLQ |..| | . .| |. || | ..| . . |.| .|...|.... | ..| ..|.|..|........||.|..||. |.|.|| .. .. DKKGTDTWWLGVCAKGINVYQVQDNNKITPMNTFPWPEIRKISFKRKKFFIKLRDDPDEGEKYEHTHTFYMPNYRACKYLWKCCVEHHQFFRLRRPPDT |
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| FERM | PTPN21.AA | FERM_N | 27-105 | 31 | 6.6e-26 | 95.56 | Pfam | 1-93 (93) | Show / Hide |
Range on Protein: 27-105 Range on HMM: 1-93/93 Sequence Identity: 31% (29 aa) IQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWY---YNKQ--NQR-RWVDLEKPLKKQLDK--------YALEPTVYFGVVFYV ..||. . .|.|. ...|||| ...|.|.|..|| ||.|.. | ||. .|.|..|...||... . . .|..| | ||. VHLLDDTQLECTCDKKTTGQELFDQVCQHLNIRECWYFGLQFCKQNDKKEGNQHMHWLDPDKKICKQMKDGWKHKIKKKCPPCTLFFRVKFYP |
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| Phosphatase | PTPN21.AA | Subfamily.N14.PD | 895-1169 | 67 | 4.1e-150 | 489.7 | In-house | 1-275 (275) | Show / Hide |
Range on Protein: 895-1169 Range on HMM: 1-275/275 Sequence Identity: 67% (187 aa) MVFTEYERILKKRLvDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIA .|||||||| |||. |...|||.||||||.|||.|||||.|.||||.|||||.|||||||.|||||.| |..||..||||..|.|||||||||||...|. kvfteyeripkkre-dallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfwqmvweqgvqliv MVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNST |.|.|||.|.||||.|.|.|.|...||..|.||.||.|..||....|||||.|||....|||||||||||||.||.|||.|||||.|||.|||||.|||. mlteeeedgkeksfkylPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsfLeevqsvrrktnse SDP-QSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK ... .. .||.|||||||||||||.|||...||.|||||..||..||..||.|||.|||||.||.|||.|||..|| vesvkeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLrkqrmllvqtlaqykfvykvlikylk |
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| Phosphatase | PTPN21.AA | PTPc | 895-1169 | 31 | 1.8e-112 | 380.84 | SMART | 1-308 (308) | Show / Hide |
Range on Protein: 895-1169 Range on HMM: 1-308/308 Sequence Identity: 31% (100 aa) MVFTEYERILKKRLVD--------GECSTARLPENA--ERNRFQ-DVLPYDDVRVELVPTKE-----NNTGYINASHIKVSVSGIEWDYIATQGPLQNTC ....|.||. . . | .|..|..|||. ..||.. |...||. || | |... ....||||..|.. . . ||.|||||..|. GFWEEFERLQRMTPWDLMSNYDPCCSCTCACWPENREMDKNRYKCDIPCYDHTRVKLKPPPGESHCYEGSDYINANYIDGY--WRPKRYICTQGPLPHTI QDFWQMVWEQGIAIIAMVTAEEEG--------GREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSG-CYATTGLKMKHLLT--------GQERTVWHLQ |||.|||.|...||.| . ..|. |||| .|||. ..|||....|.. . .| .. .. .. . ...|||.|.. EDFWRMVWQQKCHIIVMLCNCMEKCTENRDQNGREKCHQYWPDE-----PMTYGHITVTCKSEEKCPDDYTMRTFEVTNTGCNCKYSMACSETRTVTHYH YTDWPEHGCPEDLKGFLSYLEEIQSVRRHT----------NSTSDPQSP-NPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMML ||.||.||.||. ..||...... ....| || .. ... ..| .||||||.||||. .. .||. ..|. .||. .. |.|.||... YTNWPDHGVPESPDSFLDFIRQVRHWQSHSPNMYMNMVSSNS-KYHHTCPTGPIVVHCSAGCGRTGTFCAIDIMCQQIEN---VDIFQIVKMMRNQRPGM VQTLCQYTFVYRVLIQFLK |||..|| |.||......| VQTEEQYIFCYRCILEYIK |
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| Phosphatase | PTPN21.AA | Y_phosphatase | 921-1166 | 34 | 2e-103 | 354.69 | Pfam | 1-243 (243) | Show / Hide |
Range on Protein: 921-1166 Range on HMM: 1-243/243 Sequence Identity: 34% (87 aa) NAERNRFQDVLPYDDVRVELVPT-KENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGR-EK-SFRYWPRLGSR | |.||. |...||. || | |. .... ||||..|.. ... .. ||.||||...|. |||.|||.|....|.|.. ..|.|| || .||| . NKEKNRYKDIPCYDHTRVKLQPIPGDEDSDYINANYIDG-PYWNPKAYICTQGPMPHTIEDFWRMVWQQKCTCIVMLCNCMEMGRDEKTCHQYWPD-NKE HNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLT--GQERTVWHLQYTDWPEHGCPED-LKGFLSYLEEIQSVRRHTNSTSDPQSPNP--PLLVHCSAGV . ..|||.|..|.. . .| .. ..... . ...|||.|..||.||.||.||. |..|........... .. .. | .||||||. GQPMTYGDFQVTCVSEEHCPDYTVRTFEVTN-GDQKQETRTVTHYHYTNWPDHGVPESQPKSMLDFIRQVRKWQP--------NPDHGCPPIVVHCSAGC GRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ ||||. .. .||. ..||....||. .. ..|.||...|||. || |.|..... GRTGTFCAIDIMCQQMEHEGTVDIFQIVKHMRNQRPGMVQTEEQYIFCYQCILE |
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| Phosphatase | PTPN21.AA | Subfamily.N3.PD | 896-1166 | 38 | 6.3e-79 | 256.0 | In-house | 2-258 (261) | Show / Hide |
Range on Protein: 896-1166
Range on HMM: 2-258/261
Sequence Identity: 38% (104 aa)
VFTEYERILKKRlVDGECSTARLPENAERNRFQDVLPYDDVRVELVptkENNTGYINASHIKVSVSG--IEWDYIATQGPLQNTCQDFWQMVWEQGIAII
| ...|.. .|. . .|.||.|||...||..|.||||. ||.|. |..| ||||..... ... . ||||||||..|..||||||||| . .|
vlaqfeelyrkk-pglaisaarkpenlaknryrdilpydatrvklk---esetdyinanyvnmeipstglvnryiatqGplaktakdfWqmvweqkstli
AMVTAEEEGGREKSFRYWPRlgsRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRrhtns
|.| | || | .|||. ......|.|... . . . | . | .|. | .||.. .|||..||.|| |.| . ||...|.....|
vmlttlverGrvkChqyWPe---tedelefgefsvrcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr-----
tsdpQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ
.. ..|..||||||.|||||.|| |. .| .|..| . .. .. ..|.||.||||| ||.|| ...
----sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtvsqykfvCeailk
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| Phosphatase | PTPN21.AA | Subfamily.N13.PD | 907-1169 | 37 | 2.5e-71 | 231.4 | In-house | 13-259 (259) | Show / Hide |
Range on Protein: 907-1169 Range on HMM: 13-259/259 Sequence Identity: 37% (97 aa) RLVDgECSTARLPENAERNRFQDVLPYDDVRVELvptkENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREK . .| .|.... || ..||...|||||. ||.| ....||||||.||| | |..|||.|||| .|..||||||||| .|||||| |.|. | kpld-tcevgkkkenkdknryrnvlPydetrvkl----gdeggyinaslikvpvgedeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvk SFRYWPRLgSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRhtNSTsdpqspnpPLLV |||| ..... ..|.... .. .. |..|.. .|. | | ||....||.|| | . .. .. |...... ... |..|| chrywPer-knkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaelvqfvaevrllqt--dag--------Pivv HCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK ||||.||.||.| .... .|... .|. .. ||.|| .||| || |||..... || hcsaGiGrsGvlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk |
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| Phosphatase | PTPN21.AA | Subfamily.N_Choan_1.PD | 908-1168 | 36 | 4.4e-67 | 217.4 | In-house | 13-261 (262) | Show / Hide |
Range on Protein: 908-1168 Range on HMM: 13-261/262 Sequence Identity: 36% (96 aa) LVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKE-NNTGYINASHIKvSVSGiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREK || .. .. .|| ..||.... || ||.. |..| .|| ||||.... ...| | .|||||||. .....|||||||| ..|.|||.| |.|. | gvdntataskadenvlknrysnivayDatrvkvtpneenkntDyinanfvp-gykg-ekeyiatqgPvPaslvsfWqmvweqkvsaivmvtreieagklk SFRYWPrlgSRHNTVTYGRFKITTRFRTDSGCYATTGLKMkHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNStsdpqspnPPLLV |||| ......| ..... .... |.. .|. . .|..|.| .|.|| ||.|| |.. |.|.. ......... . ||..||| ChryWP---denselklgdvtvkslseeekktyierkfkl-eresgetreveqlaytaWPdhGvPattkellefrkavlkatkkktk--------aplvi HCSAGVGRTGVVI-LSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL |||||||. | | .. |. |..|.||. |. ||..|...|||| ||.|||... . | hCsaGvGrtGtyialDrlvkaveekaealdvkavvaelrkernlmvqtlvqyefvykavldal |
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| Phosphatase | PTPN21.AA | Subfamily.R_Anemone_2.PD | 896-1168 | 36 | 5.7e-66 | 213.9 | In-house | 2-261 (262) | Show / Hide |
Range on Protein: 896-1168 Range on HMM: 2-261/262 Sequence Identity: 36% (99 aa) VFTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKE-NNTGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIA ...||||. ... ....| | |. .||....|.||. ||.| .... ... ||||..| . . |||||.|| .|..|||.|||||. |.| lseeyerlsrseetsvtlksalepvnkaknryanilaydktrvklqmlegeegsdyinanyidGyrr--kkayiatqaPlpetiedfWrmvWeqnsaviv MVTAEEEGGREKSFRYWPRLGSRhntvTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRhtnst |.| ||| |. | |||| ||| .||. ... . ..... | .|.|. . .||.|.||.||..| ||. ..|. . ..... . mltqeeergkakvhryWPskgsr----sygklvvelkeevelsdyvlrsfkvkrteeeeerqvrqfhytsWpdegvpesgaslldlvrqvekaqq----- sdpQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL .| . |..|||||||||||| | .|.. .......|. ... .||.|| ..||| ||.|.| ||...| ---esgagpivvhcsaGvGrtGvfiavdillerikaealvdvfqtvkqlreqrnlmvqtkdqyefiydvlleal |
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| Phosphatase | PTPN21.AA | Subfamily.RB.PD | 904-1168 | 37 | 1.1e-65 | 212.8 | In-house | 9-260 (261) | Show / Hide |
Range on Protein: 904-1168 Range on HMM: 9-260/261 Sequence Identity: 37% (99 aa) LKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTK-ENNTGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEG ||| | ....|....| ..|||. .|||| ||.| .| |..| ||||..|. | . .||||||||..| .|||.||||. |||.| |.| lkkvgkdqavkaaeeavnraknrftnilpydhsrvkLaalkdesdtdyinanyipgyns--preyiatqGPlpetvddfWrmvwekkssiivmltqlvEk GREKSFRYWPRlgsRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHllTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNStsdpqspNP .|| .||| ...|.|| |.| .. ... .|... ..|.| ....| ||.|| ||. | |........... | . |.. gkekceeYWPa---deepvlyGdikvtllaekeldewvirefkiek--gkekrkvrqyhftsWpdhgvPektktlldfvrtvreaiekkas-------kk PLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL |||||||||||. | . .. .|.|...|. |. ||..|..||||. || |....|...| PivvHCsaGvGRtGtfialdrllqaieendyvdvfgvvaelReeRnllvqtekqyifiheclldll |
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| Phosphatase | PTPN21.AA | Subfamily.R_Sponge_2.PD | 909-1168 | 36 | 5.5e-65 | 210.6 | In-house | 13-261 (262) | Show / Hide |
Range on Protein: 909-1168 Range on HMM: 13-261/262 Sequence Identity: 36% (93 aa) VDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKENNTGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSF ....|.|.|.|| .|||...||||. ||.| ....... |||||.. . . . .||||||||..| .||| ||||. . .| |.| || |.||. . tefslsiaklkenvgKnRfkeilpydmsRvrLrtdgskdsDYinAsfvdgykr--rkayiatqgPlketveDfWRmvweykvstivmltnleengkekca RYWPRlgSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLT-GQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQsvRRHTNSTsdpqspNPPLLVH |||. ...|.||.||.| . .. . |.. ||... . ..|..| . ... ||||..|.|.|. ..... | ...| | .. |.||.| kYWPe--kvdeeveygkfkvtlkeeekladyiirklklskekssegeadvtqfhfvaWpehevPkdatsllelikrvl--raqkksg------nkaitvv CSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL ||||| | .... |...|..|. .|| || .|..|||. || |.. .| ... CsdgvgrtGtfialdsvlerlkaeeeidvfevlktlrtkriglvqdaaqYvfihdalleyi |
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| Phosphatase | PTPN21.AA | Subfamily.N9.PD | 898-1167 | 34 | 7.1e-64 | 207.1 | In-house | 4-273 (275) | Show / Hide |
Range on Protein: 898-1167 Range on HMM: 4-273/275 Sequence Identity: 34% (94 aa) TEYERIlKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKEN-NTGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMV ||. | ... | |. ...|. | |.||..||| ||. || | ..|. .. ||||.... . .|||||||..|..|||.|||||. .| |.| keyadi-rnepveGtflasklranleknrytdvlcydetrvklakldedeasdyinanfvdGykq--kkafiatqGplkktvsdfwrmvweqevlvivmt TAEEEGGREKSFRYWPRlgSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRR----HTN .| || | .||| ..... .| ..... . | .. |..|. |...|.| | |.. ||..| |.. . .|||.... . . ..| trvvergrlkcgqywpl--eeessaefgdlsvsnveveveedykvrvleiknvkteesrkvthfqflswPdyGvPssaaslldvlekvrekqalavkelg STSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQF . .||..||||||.|||| | .| .| ||. ...|. .. .||.|| .|| ||.| | .... deskghlsgPPivvhcsaGiGrtGtfitldiclarleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley |
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| Phosphatase | PTPN21.AA | Subfamily.N6.PD | 896-1168 | 30 | 1.2e-63 | 206.3 | In-house | 14-294 (295) | Show / Hide |
Range on Protein: 896-1168 Range on HMM: 14-294/295 Sequence Identity: 30% (88 aa) VFTEYERILKKRLVDG-ECSTARLPENAERNRFQDVLPYDDVRVELVPTKENNTG--YINASHI--------KVSVSGIE---WDYIATQGPLQNTCQDF . .|.|.. |. . ... .. .||.| ||....||.|. || | .... .| ||||..| . .... | ||||||.|..| .|| fweefeelqkqeseklysrkegekienkeknryknilPfDhtrvilkdgepsvpgsdYiNanyirlpkaskssgenveseehqkryiatqgcLkdtvsdF WQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNtvtYGRFKITTRFRTDSGCYATTGLKMKHL-LTGQERTVWHLQYTDWPEHGCPEDLKGFLSY |.|||.. .| |.| | | |..| |||| ..... .|. ..|. . | ....| ..|........||.||.|.| . .|..| WrmvwqensrvivmttkevergknkCarYWPdeetkke---tGvitvtsisEkstadYtlRefsvshkdkdkeareifqyhfkaWPdhgvpkdpgvvlnf LEEIQSVRRHTnstsdpqSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEV---LDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL |.... ... . . |..||||||.|||| .|. .|.. .|.. . .|| ... ..|.|| |||||| |||... ... ledvnkkqeel-------ekagpivvhcsaGiGrtGtfividivlkiieqsgldvdidisksikdvrsqrsglvqteaqykfvykavqfyi |
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| Phosphatase | PTPN21.AA | Subfamily.N12.PD | 914-1168 | 37 | 4.1e-63 | 204.2 | In-house | 25-269 (270) | Show / Hide |
Range on Protein: 914-1168 Range on HMM: 25-269/270 Sequence Identity: 37% (94 aa) STARLPENAERNRFQDVLPYDDVRVELVPTKENN-TGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWP .... .|| ..||..|.|||| |||| ..|.. .||||..|| . . . |||.|||| .| .|||.|.||. . |. |. | | |. | |||| eagekeenvkknrykDilPydksrvelskieeeegsdyinanfikgveg--kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCeryWp RLGsrHNTVTYGRFKITTRFRTDSG-CYATTGLKMKHLltGQERTVWHLQYTDWPEHGCPEDLKGFLSYleeIQSVRRHTNstsdpqSPNPPLLVHCSAG | ......|.|..|. . ||... ...|.| ..||.||.||.|. | |. |..||.. .| . ||.|||||||||||. eeg--eeelefgefevtleeekavdddflirtLkveaq--kesrkvyqfhytaWPDhgvPssaksllel---ielvrelqe------sedaPlvvhCsaG VGRTGVVILSEIMIACLEHNEV---LDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL .| ... |... . ||. .. ||.|| |||| ||..||. ..... vGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv |
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| Phosphatase | PTPN21.AA | Subfamily.N_Choan_2.PD | 907-1168 | 34 | 3.1e-62 | 201.3 | In-house | 4-265 (266) | Show / Hide |
Range on Protein: 907-1168 Range on HMM: 4-265/266 Sequence Identity: 34% (92 aa) RLVDGECSTARLPENAER---NRFQDVLPYDDVRVELVPTKEN-NTGYINASHIKvSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEG || | |. ..|| | ||..|.|| || | . .|. .| |||| ... ..| . |||..|||..| ..||.|.||. |.|.| || rldkqevseeaiPeyarnkrlnRyndiLPsPatRvrleeleedsataYinAnyvr-GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEk GREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHllTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNp ||.| |||| .. ....| |... . . | .| |.... |..|.. | .|..||.|| |.. . || . .. .| ..... . . grkkCerYWpaepkekvkladgkikvlalseekeegyiltrlrlek--kgetrrlvHfwyntWpdhgvpreedsslstdqllkmlravrrvrkeldkae- PLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL ||||||||||||||..|. .|.. .||... .|. .... ||..|| |||. ||...|...... PllvHcsaGvgRtGtliaiDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyellykavveya |
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| Phosphatase | PTPN21.AA | Subfamily.R_Anemone_1.PD | 899-1168 | 31 | 2.1e-60 | 195.8 | In-house | 5-257 (258) | Show / Hide |
Range on Protein: 899-1168 Range on HMM: 5-257/258 Sequence Identity: 31% (84 aa) EYERILkkRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVP-TKENNTGYINASHIKVSVSGieWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVT |..|. . . | ..|| .|| ..||..|....| || | ...... |||||....| .||||.||..|..|||.|||.. |..| |.| efqrlk--eikeeekevarkaenkkknryadivaldhsRvvLeklsndeesdYinasylrasdkt--rafiatqapleetvedFWrmvwqekigviVmLt AEEEGGREKSFRYWPRlgsrhNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVrrhtnstsdP .|| .| .||| .| .||..... | . . . | .. |.... . .||.| ....|||..| |. . |......|. . nliegekkkchqYwPd-----stekygelrvslrkkevfadyiirtlvlskkketeerevvqyhftvWpdkgvPqyatavLglrrkvqks---------s QSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL . . |..|||||||||||. . . |. . ...|.|| ... ..|..| .||| ||.|....... | lagarpvvvhCsaGvgRtGaflvidamleqakkekvvDifnyvkairedrphmvqtkeqyvfihlavleal |
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| Phosphatase | PTPN21.AA | Subfamily.R_Ecdysozoa.PD | 898-1167 | 30 | 7.7e-59 | 190.2 | In-house | 4-267 (269) | Show / Hide |
Range on Protein: 898-1167
Range on HMM: 4-267/269
Sequence Identity: 30% (83 aa)
TEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTK-ENNTGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMV
.|||.. .. .. ..... ||| .||..|. ..|. || | ... .... |||||.|| . ..|| |.|...| .|||.|..|| . .| |.
eeyekLearleiskstkvsekkenalknryedikafDktrvkLkkingkedsdyinasfikgyke--kkkfiaaqdPveatigDfWrmiaeqevtlivml
TAEEEGGREkSFRYWPRLgsrhNTVTYGRFKITTRFRTDSGCYATTGLKMKHLL---TGQERTVWHLQYTDWP-EHGCPEDLKGFLSYLEEIQSVRRHtN
. ..| |. .||| ..| || ... . |. |.. . ..| |.|| |. . || .| | ..|..... .. |. |
snlteknrk-cakyWpie----devqygdilvklvseekhsdyiireldvskkkeesvedsrkvvqysytgWksDskvPevargllklieqvrelykl-n
STSDPqspNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQF
. |..|||||||||.|... .... |. .. .|| ..||.|| .||| | ||.|.|| |...
klsgs---rsPivvhCsaGvgrsgifvaldlllqqlkaedkvdifetvkkLrsqrnllvqsleqyvflyralady
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| Phosphatase | PTPN21.AA | Subfamily.RA.PD | 899-1168 | 35 | 9.8e-59 | 190.0 | In-house | 5-265 (266) | Show / Hide |
Range on Protein: 899-1168 Range on HMM: 5-265/266 Sequence Identity: 35% (96 aa) EYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTK-ENNTGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVT |.... . .. .... || ..|| ..||. ..|||| || | . |... |||||.|. .||.|||...| .|||.|.|||| | |.| efkkltsvkiqkeklrtankeenkkknrvvqilpydfsrvilsvkeGeeesdyinasfidGyre--kdkfiaaqGpkeetvedfwrmiweqksativmlt AEEEGGREKSFRYWPRLGSrhntVTYGRFKITTRFRTDSGCYATTGLKMKHLL----TGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQsvrrhtns .| ..|| .||| |. |||| ... . | . |. . ...| ..| | . .| ||| | | . |||..|.... . . elkerkeekcaqywpdeGl----vtyGeirvevkdetvledytvrdflvtqlpdatrekksrlvrqfhftswpevGvpaegkGmlkllkkvk-------- TSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL .|| | |. ||||||||||| | . ... .. ...||. .... ||.|| .|||| ||.|.|.|| ... klqqqsanhpivvhcsaGvGrtGtfivldavlervkaerkldvfeavkrlrlqrpqmvqtleqyefiykvlleyi |
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| Phosphatase | PTPN21.AA | Subfamily.N5_RR.PD | 916-1169 | 33 | 1.7e-58 | 189.3 | In-house | 18-265 (265) | Show / Hide |
Range on Protein: 916-1169 Range on HMM: 18-265/265 Sequence Identity: 33% (85 aa) ARLPENAERNRFQDVLPYDDVRVELVPTK--ENNTGYINASHIKVsVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPR ... ....||....|| . || | . . .... |||| .|| .. . |.||||||.|| .|||.|.... . .| |.| .||.| .|.| . levfgsqtknryktilPnensrvllesessededssyinanyikG-ydeeskayvatqGPlpntiadfWrmiyqeevqvivmltklkeanrqkcavyfPd LGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTgQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDpqspnpPLLVHCSAGVG . . .|| ..|... .. | . | .|.| ||.| | |||||.| |.| . .|. ..|... |...| |..||||||.|||| aedyeiserygdveikveeiverndysvrklvlkyler-versvkhywytdWPdhksPddintlldlvleveesreeenakla------PvvvhcsaGiG RTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK . | .| . |....|.|. .. ||..| .||| || ...|.|...|| rtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk |
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| Phosphatase | PTPN21.AA | Subfamily.RG.PD | 898-1167 | 32 | 1.5e-56 | 182.9 | In-house | 4-262 (264) | Show / Hide |
Range on Protein: 898-1167 Range on HMM: 4-262/264 Sequence Identity: 32% (86 aa) TEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKE-NNTGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMV ..| | | . | |..... .|| |.|| ...... ||.| |. . ... |||||.|. . .||.|||||..|..|||.|.||..|| |.| eqfeeiqklkpkdieaesskkeenkeknReinivaversRvklsplpgkdgkDYinAsyidGyrr--skeyivtqgplketiedFWrmiWehnaqiivml TAEEEGGREKSFRYWPRlgsRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERT--VWHLQYTDWPEHGCPEdlkgflSYLEEIQSVRRHTNST .| ||.. ..|||. ..........|.| .. .| .. . .|. . .|.. | ...||.||..| ||| |... .|... ..... . | tdldekgrrdedvyWPk---kdeplelealkvtllskeklskytvrdfvlkntkddkekervvrqyhytkWPdmgsPe------stlfvlifvkkeeaan SDpqsPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQF ..||.||||||.|. | . .. ||..| .. .|| ..|..| .||.| ||.|.| .|... ke---eaGPivvhdsaGvgragtyialdtllqqlekeeavnvyqvlklirakRpglvtteEqyvfiydallel |
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| Phosphatase | PTPN21.AA | Subfamily.N23.PD | 937-1166 | 31 | 1.1e-55 | 180.3 | In-house | 118-347 (350) | Show / Hide |
Range on Protein: 937-1166 Range on HMM: 118-347/350 Sequence Identity: 31% (74 aa) RV--ELVPTKENNTGYINASHIKvSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRlgSRHNTVTYGRFKITTRFRT || . . .... ||||...| ... . ..||||||...| |||.||||| .| |.| |.||.. | .||| . .|...|.... . .. rvklqqstqpgqqddyinatylk-eltpmsPpfiatqgPiastlaDFWlmvweqqssviVmltkevegnklkcdqYwPi--degetnlfgdlrvslkslr DSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILS-EIMIACLEHNEV | . |...| . . |.| ||..| |.|.| |. . .| .|.|.... . . | .. |...||||||||||.. . .... ..| .. ssegwiervlhlqhndvstvrlvchlhtttWseiGvPksPedllaflgevetayaqqrktetegeggkPiilhCsaGvgRtgtfcvvysaireltagngi LDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ .||||. ||||| ||. .. ..|.. .. iniprvvrrlrqqRkymvqkkvilkklyeavle |
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| Phosphatase | PTPN21.AA | Subfamily.RK.PD | 899-1168 | 29 | 3.9e-54 | 174.8 | In-house | 5-266 (267) | Show / Hide |
Range on Protein: 899-1168
Range on HMM: 5-266/267
Sequence Identity: 29% (82 aa)
EYERI--LKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKENNTGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMV
|.| . . .| .|..| ...| |.||..|.|.|| .| |........ ||||. | .|.||||||.| .|||..|.... | | |.
efetlnsvtpelqsedcdiakkdrnreknrsmdilaydrslvflisvdgdssdyinaalidsykr--paafivtqgPlqetvkdfWrlvydencasivml
TAE-EEGGREKSFRYWPRlgsrHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQ--ERTVWHLQYTDWPEH-GCPEDLKGFLSYLEEIQSVRRHtn
| | || | .||| . .|.|| .|.. . . . .....| || |.| ..|.. |||. . |. ...|... ...... .
teldvevgrvkClkyWPe----dtevrygdikvelveaeldadlvvrifrveklargqeeirevrqfqflgWpeyrdvPvskrsllklirrvkksqee--
stsdpqSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL
. . ...|||.|| ||.|. | .|.. .|...|.|. . ||.... .|.| ||.||| | ...|
------eeeGrivvhClaGaGrsGtfiaidivlemieregvvdvfnavktlrnrkvnmveteeqykfvydvileal
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| Phosphatase | PTPN21.AA | Subfamily.RC.PD | 914-1166 | 32 | 2.1e-52 | 169.3 | In-house | 19-285 (288) | Show / Hide |
Range on Protein: 914-1166 Range on HMM: 19-285/288 Sequence Identity: 32% (88 aa) STARLPENAERNRFQDVLPYDDVRVEL--------------------VPTKENNTGYINASHIKVSVSGieWDYIATQGPLQNTCQDFWQMVWEQGIAII || .|| ..||. |||||| |||| |. . |||||.|. |||.||||..| .|||.|..|. . .| | kiarkeenksknrysdvlpydynrvelkhelemskesehdsdessdddidseegskyinasfidsykkp--ekyiaaqGplketvddfwrmiferkvkvi AMVTAEEEGGREKSFRYWprlgsRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQ---SVRRH .| .|| ||| .|| . .|| .. . . | | |.... . |.| ..|||.|.... ||. | .|. .. .. .|... vmltelkeGdrekcaeyw-----eeGkrayGdvevdlkdtdkssdyilrklelvnkkrkdsrevtqiqytswsveqlpeepkellkliqvvkqklpqkrs TNSTSDPQSpnPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ . .. .| ||||||..|..|||. | . .. || .|..|. .|. ||..| ..|.. || ..| ||.. seafknfks--tpllvhcrdGsqrtGifiallallesleaeekvdvfqvvkklrkarplmvsveeqyillydvlve |
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| Phosphatase | PTPN21.AA | Subfamily.N20.PD | 906-1168 | 36 | 6.1e-50 | 161.4 | In-house | 11-256 (257) | Show / Hide |
Range on Protein: 906-1168 Range on HMM: 11-256/257 Sequence Identity: 36% (94 aa) KRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKEnntgYINASHIKVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGRE . . || . | | |.||..|.|||| || | .|. |||||.|.. | |. |||||||| .| .|||||| |. .|||.| | ||| | lknlpgefnsgnqpsnreknryrdilpydstrvplgkskd----yinasyirivncgeeyfyiatqgpllstiddfwqmvlennsnviamitreieggii KSFRYWPRlgSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEeiqSVRRhTNSTSdpqspnpPLL ..||| | .. . .|.. . ... || ..| .||.| ||.|| | |. |.|. . | |..||||||. kcyhywpi--slkkplelkhfrvflenyqilqyfiirmfqvvekstgtshsvkqlqftkwpdhgtpasadsfikyir---yark-shltg-------pmv VHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL |||||.. ....... .| ..| .. .|.|| .||| || |.| .... | vhcsagigrtgvflcvdvvfcaivkncsfnimdivaqmreqrsgmvqtkeqyhfcydivlevl |
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| Phosphatase | PTPN21.AA | Subfamily.N1.PD | 909-1166 | 33 | 1.2e-48 | 157.0 | In-house | 16-265 (268) | Show / Hide |
Range on Protein: 909-1166 Range on HMM: 16-265/268 Sequence Identity: 33% (85 aa) VDGECSTARLPENAERNRFQDVLPYDDVRVELvptKENNTGYINASHIKVsvSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSF . |...|.|||| ..||..|| ||| |..| ..... ||||| ... .. || ||||| .|.. |||||||| . |.| .. | . |||. keletreaklpenrglnryrdvspydhsrikl---eradvdyinaslvel--eeakrrYiLtqGPLphtadHFWqmvWeqnskavimLnkvvEknqikCa RYWPRlGSRHNTVTYGR--FKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIqsvRRhTNSTSDPqspNPPLLV ......... . .|.. . .. . . |... | | . |.. | .|| ||. | || .. ||..| .. |.. | |. |. .|||||. qywpq-eeeeaellleetklkvkliseerksyflvrlleLedletqetreilhfhyttwpdfgvpespaafLkfLfkv---re-sgsLssd---vgpavi HCSAGVGRTGVVILSEIMIACLEHNEV---LDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ ||.| . | . ... .|... .|| .|| ||..|. |.|| | | | ... hCsagigrsgtlslvdtclveiektgdlnavdikkvLlelRkyRvGLiqtpdqLrFsyiaile |
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| Phosphatase | PTPN21.AA | Subfamily.RN.PD | 905-1165 | 36 | 1.7e-46 | 149.8 | In-house | 11-260 (264) | Show / Hide |
Range on Protein: 905-1165 Range on HMM: 11-260/264 Sequence Identity: 36% (94 aa) KKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVP-TKENNTGYINASHIKvSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGG . . . ...|. ..|...|| ..|||||. ||.| ...... ||||| | . |||||||| .| ||||||||||...| ..| || | ayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasail-dhdprapayiatqgplsstiadfwqmvweqGvvvivnltrleeeg REKSFRYWPRLGSRHNTVtYGRFKITTRFRTDsgCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYleeiqsvRRHTNSTSDPQSpnPP .. |||| || . | .. .| | . .| | | . ||| . . |||.|.| | .| .|| | . .| |..||||. vkqckrywpdeGsevyhi-yevhlvsehiwcd--dylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllef-------rrkvnksyrGrs--cp LLVHCSAGVGRTGVVILSEIMIACLEH-NEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLI |.||||| || ..... | . .|| |. ||.|| ||.| |. |.. ... ivvhcsdGaGrtGvyilidlvlerllkGvkeidiaatlehlrdqrpglvktkdqfefaltava |
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| Phosphatase | PTPN21.AA | Subfamily.N_Nematode_1.PD | 919-1168 | 29 | 1e-43 | 140.8 | In-house | 24-264 (265) | Show / Hide |
Range on Protein: 919-1168 Range on HMM: 24-264/265 Sequence Identity: 29% (74 aa) PENAERNRFQDVLPYDDVRVELVpTKENNTGYINASHIKVSVSGieWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRH ..|..||..|| |. || | .. . || | .. ... .| .|.||..|..||| || . . | |.| |. | |.| ..... aqeadknrykdvgcldknrvkla-eeplpsdyihanyvgtptnp--krficaqaPldktiadfwymvlqekveaivmlckliekgkkkcaeyfpakegek NTVTYGRFKITT-------RFRTDSGCYATTGLKMKHlLTGQERTVWHLQYTDWPEHGCPEDLKGFLsyleeiqsvrrhtNSTSDPQSPNPPLLVHCSAG . ||| .|. . .| |.... ...|.| |.|.||||..| |.. | . .. .. . |..||||||.|||| | lefkekgqkitvenslgvkkleedeevikvtvleveg-aGektrkvthyqWtdWPdrGvPpadlaal-------------elleavrgskgPivvhCsaG VGRTGV-VILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL .. |. || ... |...... .|.|| . .|| || ||.|||.... iGrtGtivaieyildkllegkqiedmeklvkkireqrnysiqtdaqylfvhrvllnyf |
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| Phosphatase | PTPN21.AA | Subfamily.N_Nematode_6.PD | 919-1168 | 28 | 1.3e-42 | 137.1 | In-house | 22-252 (253) | Show / Hide |
Range on Protein: 919-1168 Range on HMM: 22-252/253 Sequence Identity: 28% (69 aa) PENAERNRFQDVLPYDDVRVELVptkENNTGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPR-LGsr .. .|||.... .| |..|. ... || |. .|.| . .| ||.||..|...||.|. .|. | |.| |.||| .| . .| .. lkfkdrnrytniqCcdagrlkla---ddedfyihanlvkistk--prrlictqaplegtieefwkmilssgveyivmlcelvekgkeksaeylsdkvG-- hNTVTYGRFKITTRFRTDS-GCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLeeiQSVRRHTNstsdpqspnpPLLVHCSAGVGRTG .... .. .. . || ...| | |... .||.|| |.... || . |.... |..||||||||||| ..| .| -darkitklctvikigrkdidkilvrslkrivkagdeevivkhihWanWPdhGvPdsflsalrll---svvkkdkk----------PivvhCsaGvGrtG VVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL ....| . . .....| ||..|. ||| || ...|....| tlaliliilealrlpdfqgvkdllvklreerfravqtevqylyalrcvleyl |
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| Phosphatase | PTPN21.AA | Subfamily.N_Nematode_5.PD | 914-1169 | 24 | 7e-40 | 128.0 | In-house | 18-258 (258) | Show / Hide |
Range on Protein: 914-1169
Range on HMM: 18-258/258
Sequence Identity: 24% (63 aa)
STARLPENAERNRFQDVLPYDDVRVelvPTKENNTGYINASHIKVSVsgIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSfRYWPR
.. .| ..|| .|| .|. || .... .|||||.||. .| ..| || ||..| .|||.|| .. |. . ... .|| . . ..|
tckafeknlkknrskdvkilDetrV---kltdeddsYinaskikldd--lekkliltQlPlpdteedFWrmvyqekitsvvllvedeelketav-sffpl
LGSRHntVTYGRFKITTR-FRTDSGCYatTGLKMKHLLTGQ--ERTVWHLQYTDWPEHGCPEDLKGFLSylEEIQSVRRHTNSTSdpqspnPPLLVHCSA
..| . |..| . ... .. . .... | |. . . . ..| |... |..| . .|..| ....... .|..|....|
etgdy--lnlgkmfinnrkvevkedek--keytvevlpegcsesvfakvyhlttWkkkkvPdkvkkvik--raiekvlskkqgkn------apvvvvsdl
GVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK
.||.| ..| ...| .|.... ..| .| ..|.||. |..|.||..||.......|
GlgRagtflllsvaieqlnngkepnideilkkirsqRpgavesliqyasvyaavldyik
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| Phosphatase | PTPN21.AA | PTPc_motif | 1056-1166 | 31 | 3.9e-39 | 137.25 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 1056-1166 Range on HMM: 1-92/92 Sequence Identity: 31% (37 aa) TVWHLQYTDWPEH-----GCPEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMML ||.|..||.||.| |.|| ...|........ |..||||||.||||.... ..|. . .|| .. ..|.||... TVHHYHYTNWPDHVEKDSGVPE--DSILEFIRHVRK----------------PIVVHCSAGCGRTGTFCAIDMMMQQ------VDIFQTVKEMRKQRPGM VQTLCQYTFVYRVLIQ |||. || |.||.... VQTEEQYIFCYRCILE |
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| Phosphatase | PTPN21.AA | Subfamily.N_Nematode_4.PD | 910-1167 | 28 | 2.1e-37 | 120.1 | In-house | 15-262 (264) | Show / Hide |
Range on Protein: 910-1167 Range on HMM: 15-262/264 Sequence Identity: 28% (77 aa) DGECSTARLPENAERNRFQDVLPYDDVRVELVpTKENNTGYINASHIKVSvsgIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFR .. . .|...||..|.| |. || | .. . || || ... . ||.|||||..| .||| ||... ||.. |. .|.| || ||. ppnvtasaseknsdknryadilcidetrvvlk-nrdpdndyihaswmrmP---dkfryistqGPlketlsdfwhmvytekiavvvmlcdlieegvekcar YWPRlgSRHNTVTYGRFKITTRFRTDSgCYATTGLKMKHL--------LTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLeeiQSVRRhtNSTSDpqspn | ...|..|...|| .. ..| . |. .. . .. | |.|.. |... |.| . . . . |. .. . | yype--ksekvvkfGkyritlvekkee-viadvilnslkvtntekkkdapseplvvkhvqvdwwrdqvaPldaapvikly---kavkk--kkkek----- pPLLVHCSAGVGRTGVVI---LSEIMIACLEHNEVLDIprvLDMLRQQRMMLVQTLCQYTFVYRVLIQF . |||||||||| .. ...|.| . ||||| . ||. |. ||. |. |.. |||.. -PivvhcsaGvGrtatlvGidyatirirenseievldi---vrelramrlkavqshlqflfllvvliel |
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| Phosphatase | PTPN21.AA | Subfamily.R_Nematode_2.PD | 921-1167 | 29 | 4.2e-37 | 119.0 | In-house | 29-259 (261) | Show / Hide |
Range on Protein: 921-1167 Range on HMM: 29-259/261 Sequence Identity: 29% (68 aa) NAERNRFQDVLPYDDVRVELVPTKENNTgyINASHIKVsvSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLgsRHNT .....|..|| .. .|| . . | | .. .| . .|||||||.||..||| || . . | |.. |.|| .|.| ..... pkdkhRypdvPCkpetavevivdgkrvp--ihanwvpt--agnpkrfiatqgPlentsedfWamviqekvekivmlcqkvekekekceeYfple--tsqk VTYGRFKITTRFRTDSGC--YATTGLKMKHLlTG--QERTVWHLQYTDWPEHGCPEDLKGFLsyleeiqsvrrhtNSTSDPQSPNPPLLVHCSAGVGRTG |||.|.| . . ||.. || . ||| |.||..||..| |. .. . . . |..||||||.|||. .| .| . .|... . ldlgrfsiktvsaekilkdeiekrtlkveds-tgkfatrtvthyqyeeWpdrgvPkshaelf-------------eLlelvkksekPivvhCsaGiGRtm VVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQF . . |. ||..|.. .|| |. .. .... afigteylareveadptieltealkelrehRwkgiqtesqlywltlgalyr |
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| Phosphatase | PTPN21.AA | Subfamily.R_Nematode_3.PD | 920-1168 | 21 | 2.1e-31 | 100.4 | In-house | 22-266 (267) | Show / Hide |
Range on Protein: 920-1168 Range on HMM: 22-266/267 Sequence Identity: 21% (57 aa) ENAERNRFQDVLPYDDVRVELVP-TKENNTGYINASHIKVSvSGIEWdyIATQGPL--------QNTCQDFWQMVWEQGIAIIAMVTAEEE---GGREKS .. . .| ..|. . . || |. | . ..|.|. .... .|... | ||.|. ..|.. ||.|. ... ....|. | .. ||. kkvsedrrvevpllektrvvLkgygkrfkddfihAnvvecp-nglkl--IltqsPqkkdkekkkkstieKfwwmieqekveqvvmlcdfveedgeeeekc FRYWPRlgSRHNTVTYGRFKITT-RF-RTDSGCYATTGLKMkHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRrhTnstsdpqspnpPLL .|.| . .. ....... . | . |.. .. ..| || ||.|..|.|..||. | .|. .. ..... | |..| seYype--kvdgelkfegvsvkctdikkelsedvekrtlvv-tfekkkeftvthllykgWkelnapeepkealelikfveksk--t-----------pvv VHCSAGVGRTGVVILSEIMIACLEHNE-VLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL |||.|..|... |. . . ... ||. ... ||.|| ..|| ...|| .....| VHCsdGisRsatlaaielgyqliikskgkldllslikelrkqRagaiqtelelafvilgilkll |
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| Phosphatase | PTPN21.AA | Subfamily.N_Nematode_eak.PD | 912-1168 | 24 | 9.6e-26 | 81.9 | In-house | 18-280 (281) | Show / Hide |
Range on Protein: 912-1168 Range on HMM: 18-280/281 Sequence Identity: 24% (65 aa) ECSTARLpENAERNRFQDVLPYDDVRVELVPTKENNTGYINASHIKVsvSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYW . |||| |. .||| ...|.| |.| ... |. |||||| .. | . || | . .. ||||| ||| .. . | . ||| .|.| . irvtarl-eavnrnrvvkivpqdrylvrltssqlnrdGyinaslaef--sevGrkyiltGiasedkvfafwqmvleqkspaivqlledveekleksdkyf PRLGsrhNTVTYGRFKITTR-FRTDSGCYATTGLKMKHlltGQE-RTVWHLQYTDWPEHGCPE--DLKGFLSYLEEIQSVR------RHTNSTSDPQSPN . . || ...... . . . | |... |.| | | .. | || |. . . |. . .|| || . pdkt---evlkyGildverkeyavkrniletrllilrk---GnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallrstlkkyiht PP---LLVHCSAGVGRTGVVILSEIMIACLEH--NEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL . .. | |.|| .. ...| .. ... ... ...|. | . |..|.| .....| ppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyl |
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| Phosphatase | PTPN21.AA | Subfamily.N_Nematode_egg.PD | 914-1168 | 25 | 2.5e-24 | 77.2 | In-house | 19-256 (257) | Show / Hide |
Range on Protein: 914-1168 Range on HMM: 19-256/257 Sequence Identity: 25% (64 aa) STARLPENAERNRFQDVLPYDDVRVELV-PTKENNTGYINASHIKvsVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGgrEKSFRYWP .|| .. |. | . | . ||.| . .| | ..| . ..| .| ||.|| .|||.||... .| |.|. | |. |||. ttaasdnylekarskrvhckessrvklelrrGqylddfihanrvk--Gkpllnefilaqaplkntvedfwrmvfqekvqyivmltsakes--erceyywp RLGSRHNTVTYGRFKITTrFRTDSGC---YATTGLKMkhllTGQERTVWHLQYTDWpehgcpeDLKgFLSYLEEIQSVRRHTNSTSDpqspnpPLLVHCS | . | ..|.. .. || . | ||. | .. .|.. .|.. .|| . | |. | | .|.. || ..... kaeseslvtvpGslrien-lkvdskadplfrvtklkl----vGgddeelflehwqg-------dvn-ylsdvysplrvlrklrnlsk------pvvvqdi AGVGRTGVVILSEIMIACLEHNEVL--DIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL . || . | . . | .||..|. |.. .| ||||....|. lGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlffi |
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| Phosphatase | PTPN21.AA | Subfamily.N_Fungi_PTP1.PD | 922-1022 | 30 | 4e-24 | 76.4 | In-house | 46-159 (343) | Show / Hide |
Range on Protein: 922-1022 Range on HMM: 46-159/343 Sequence Identity: 30% (34 aa) AERNRFQDVLPYDDVRVELV----PTK-----ENNTGYINASHIKVSVSGIE----WDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSF .||....|||. ||.| ... . ||||...|... ..| . |||||.||..| .||.... . ...| ..|.. | ..|| ||| faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy RYWPRLGSRHNTVT .... || rYWqegsydditvk |
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| Phosphatase | PTPN21.AA | Subfamily.N_Fungi_PTP1.PD | 1051-1166 | 31 | 7.6e-16 | 49.1 | In-house | 209-340 (343) | Show / Hide |
Range on Protein: 1051-1166 Range on HMM: 209-340/343 Sequence Identity: 31% (39 aa) TGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDP-QSPNPPLLVHCSAGVGRTGVVI-----LS--EIMIACLEHNEVLD------- .. .|..||. |.. . . . .|. || . . .. | .. .|.||||||||||||... || ||... . || | . vsepyevyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrD -IPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ . ||.||. .||.| |. |.| | lisiivnelrkqrismvqnldqfifiYeallf |
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| Phosphatase | PTPN21.AA | Family.DSP.PD | 1030-1147 | 26 | 8.4e-08 | 23.1 | In-house | 148-226 (387) | Show / Hide |
Range on Protein: 1030-1147
Range on HMM: 148-226/387
Sequence Identity: 26% (25 aa)
TrfrtdsgcyattglkmkhlltgqERTVWHLQYtDWPEHGCPEDLKGFLSYLEEIQSvrrhtnsTSDpqSpNPPLLVHCSAGVGRTGVVILSEIMIAcle
| . .|.. .. |..| . | . .. |.. | | . |||| ||.||.|..| .| . | | . ||..|..|
k-----------------------elgikylri-pidDhnapplenlfekaidfiee-------gnd--s-kgvVlVHCkaGkgRsgtliiaYlmks---
hnEVLDIPRVLDMLRQQR
--egltleealdwvrskR
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| Phosphatase | PTPN21.AA | Subfamily.PTPDC1.PD | 1106-1160 | 32 | 2.2e-06 | 18.5 | In-house | 171-220 (229) | Show / Hide |
Range on Protein: 1106-1160 Range on HMM: 171-220/229 Sequence Identity: 32% (18 aa) VHCSAGVGRTGVVILSEIMiacleHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFV ||| || |||||.| . .. ... |. . ....|..| .|| | .| vHCHAGlGRtGvliacylv-----yakrltaeeaiklvrskrpksiqtreqvelv |
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