PTPN23
Species: Human
Alias: PTPN23, DKFZp564F0923, KIAA1471, PTP-TD14, HD-PTP, HDPTP
External Links: COSMIC , Entrez Gene
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: Classic_PTP
Subfamily: N23
Protein domain

Protein domains of PTPN23.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
BRO1 PTPN23.AA BRO1 8-384 36 6.4e-170 575.6 Pfam 1-420 (420) Show / Hide
Range on Protein: 8-384
Range on HMM: 1-420/420
Sequence Identity: 36% (155 aa)

PMIWLDLKEAGDFHFQPAVKKFVLKNY-GENPEA---YNEELKKLELLRQNAVRV--PRDFEGCSVLRKYLGQLHYLQSRV--PMGSGQEAA-VPVTWTE
||||. ||.. .. .  ..|......| |..|..   |......|. |||.|...   ....|...| .|.|||..|..|.  |.. ... . |. ||..
PMIWIPLKKTKEVDWTKPLKNYIKNHYSGQDPWMQFYYEDDCAELNQLRQDARNPCPSPHESGLELLYRYYGQLCWLEKRFFPPFH-DDRHIGVEFTWYD

IF----SGK-----SVAHEDIKYEQACILYNLGALHSMLGAMD----KRVSEEGMKVSCTHFQCAAGAF---AYLREH----FPQAYSV-DMSRQILTLN
 |    .|.     .|.. ....|.||.|.|.|||.| ..|.      | ..||.| .|..||.|||.|   .||.|.    | .| || |||.. |   
AFDHRSHGSSFGRRPVCQNNLAFEKACVLFNIGALYSQIAASQYESDNRDTDEGLKQACHYFQQAAGCFDCAQYLNENVPAEFLHAPSVYDMSPETLKCL

VNLMLGQAQECLLEKSML---D-NRKSFLVARISAQVVDYYKEACRALENPDTASLLGRIQ-KDWKKLVQMKIYYFAAVAHLHMGKQA--EEQQKFGERV
|||||.|||||...|...   | ..|  |.|...|||.|||.|..||. . ...    ... |.|...||.|...|.||||.......  ||..|.||..
VNLMLAQAQECFWQKAINQDIDMGMKDSLIAKLAAQVSDYYQECHRAMQKSPYKCY--YWPWKEWIHHVQCKQHHFKAVAHYYHALHCCDEEKKKYGEAI

---AYFQSALDKLNEAIKLAKG--QPDTVQDALRFTMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTD-----PAVTGPDIFAKL
   |..| |...|.||.|..|.  ... .||.|....|.|. |...|.||||||||| || ...| |.|....|||.|.| ..     .....||.|.||
DLKAHLQHAQQCLKEAQKKHKKCYVNY-LQDDLKYLHDRIQEKLKRAEKDNDFIYHEPVPDEVSLPPIKPMDMVKPIPWNEVFEPQEATKHKCPDLFKKL

VPMAAHEASSLYSEEKAKLLREMM
|||| |||.|.|||.|.|..|.  
VPMAVHEAASIYSERKDKYVRNEI

Phosphatase PTPN23.AA Subfamily.N23.PD 1189-1453 43 6.30000000001e-106 345.4 In-house 38-349 (350) Show / Hide
Range on Protein: 1189-1453
Range on HMM: 38-349/350
Sequence Identity: 43% (135 aa)

GALDTVWRELQDA--QEHDARGRSIAIARCYSLKNR--HQDVMPY--------------------------------DSNRVVLR-----SGKDDYINAS
|. .|.|.||.|.  ||..|. .|||.|...| |||  ..|..||                                |.|||.|.     ..||||||..
gpvetlwseledyqgqeaiaadqsiasakrmsnknrqfnpdllpyhlqpttitavpqprhlqtegsGqqqgtpdsrhdpnrvklqqstqpgqqddyinat

CVEGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSL
.. |.|..||..|||.|.. |.|||||||.||..||||||..|.|..|.|...|.|...|.....|.|...|.|.||.|...||||.||..|.| .|...
ylkeltpmsPpfiatqgPiastlaDFWlmvweqqssviVmltkevegnklkcdqYwPidegetnlfgdlrvslkslrssegwiervlhlqhndvstvrlv

VHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHT------PIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLH
|||. ||.|.|.|.||..||.|..||...| .||  .|      |||.|||.||||||.|...|.|..|..|||||...|..|||.|||||.|.|.| .|
chlhtttWseiGvPksPedllaflgevetayaqqrktetegeggkPiilhCsaGvgRtgtfcvvysaireltagngiiniprvvrrlrqqRkymvqkkvi

LRFCYEAVVRHV
...||||.... 
lkklyeavleaa

Phosphatase PTPN23.AA PTPc 1190-1454 27 6.8e-94 319.16 SMART 1-308 (308) Show / Hide
Range on Protein: 1190-1454
Range on HMM: 1-308/308
Sequence Identity: 27% (87 aa)

ALDTVWRELQDAQEHDAR-----GRSIAIARCYS----LKNRHQ-DVMPYDSNRVVLRS--------GKDDYINASCVEGLSPYCPPLVATQAPLPGTAA
 . . . .||... .|.       .|. .|. .      |||.. |...||..||.| .        . .|||||. ..|  ..     .||.|||.| .
GFWEEFERLQRMTPWDLMSNYDPCCSCTCACWPENREMDKNRYKCDIPCYDHTRVKLKPPPGESHCYEGSDYINANYIDGY-WRPKRYICTQGPLPHTIE

DFWLMVHEQKVSVIVMLVSEAEM--------EKQKVARYFPTERGQPMVHGALSLALSSVRSTE-THVERVLSLQFRDQ--------SLKRSLVHLHFPT
||| || .||...||||... |.         . | ..|.| |   ||..| ... . |. ...   . |...... ..        | .|.. |.|...
DFWRMVWQQKCHIIVMLCNCMEKCTENRDQNGREKCHQYWPDE---PMTYGHITVTCKSEEKCPDDYTMRTFEVTNTGCNCKYSMACSETRTVTHYHYTN

WPELGLPDSPSNLLRFIQEVHAHYLHQ----------------RPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQE
||..| |.||. .|.||..|.... |.                .. ..||.|||| |.||||.|... ...| .|.    . ..|.|..||.|| .| | 
WPDHGVPESPDSFLDFIRQVRHWQSHSPNMYMNMVSSNSKYHHTCPTGPIVVHCSAGCGRTGTFCAIDIMCQQIEN----VDIFQIVKMMRNQRPGMVQT

KLHLRFCYEAVVRHVE
. ...|||... . ..
EEQYIFCYRCILEYIK

Phosphatase PTPN23.AA Y_phosphatase 1217-1451 33 2.3e-92 317.94 Pfam 1-243 (243) Show / Hide
Range on Protein: 1217-1451
Range on HMM: 1-243/243
Sequence Identity: 33% (83 aa)

YSLKNRHQDVMPYDSNRVVLR----SGKDDYINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEK-QK-VARYFPT-ERGQ
   |||. |. .||..||.|      . .|||||. ..| ....    .||.|.| | .||| || .||...|||| .. ||.. .|  ..|.|. ..||
NKEKNRYKDIPCYDHTRVKLQPIPGDEDSDYINANYIDGPYWNPKAYICTQGPMPHTIEDFWRMVWQQKCTCIVMLCNCMEMGRDEKTCHQYWPDNKEGQ

PMVHGALSLALSSVRSTETHVERVLSLQFRDQ--SLKRSLVHLHFPTWPELGLPDS-PSNLLRFIQEVHAHYLHQRPLHT--PIIVHCSSGVGRTGAFAL
||..| ..  . |. ...  . |...... .   . .|.. |.|...||. | |.| | ..|.||..|. ..   .| |   ||.|||| |.||||.|..
PMTYGDFQVTCVSEEHCPDYTVRTFEVTN-GDQKQETRTVTHYHYTNWPDHGVPESQPKSMLDFIRQVRKWQP--NPDHGCPPIVVHCSAGCGRTGTFCA

LYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVR
. .. | .|... . ...|.|..||.|| .| |   ...|||.... 
IDIMCQQMEHEGTV-DIFQIVKHMRNQRPGMVQTEEQYIFCYQCILE

Phosphatase PTPN23.AA Subfamily.N3.PD 1219-1452 35 1.7e-57 185.7 In-house 28-259 (261) Show / Hide
Range on Protein: 1219-1452
Range on HMM: 28-259/261
Sequence Identity: 35% (83 aa)

LKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPY---CPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTeRGQPMVHGA
|||..|..|||. || |.... |||||. |.  .|        .||| ||. ||.||| ||.|||...|||| .  |  ..|  .|.|... . .| .|.
aknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGplaktakdfWqmvweqkstlivmlttlverGrvkChqyWPe-tedelefge

LSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYlhqRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAG
 ... ..|...| | | |. .... .|....| .  ||. |.||.....|.|...|..     .  ..|..||||.|.|||| . ||  |.. .|| . .
fsvrcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr---sgkeePvvvhCsaGigrtGvlilletalalieaa

NGIPELpQLVRRMRQQRKHMLQEKLHLRFCYEAVVRH
  | ..||.||.||. ..| .   .|  ||...    
epvypl-divrtmrdqramlvqtvsqykfvCeailka

Phosphatase PTPN23.AA Subfamily.RB.PD 1211-1451 32 5e-56 181.1 In-house 20-258 (261) Show / Hide
Range on Protein: 1211-1451
Range on HMM: 20-258/261
Sequence Identity: 32% (79 aa)

IAIARCYSLKNRHQDVMPYDSNRVVL----RSGKDDYINASCVEGLSPYcPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTE
| ... . |||.. ..|||..|| |     . ..|||||. ..| .      .||| |||.|  ||| ||.|.|.|.||||.   |  |.|. .|.|...
aaeeavnraknrftnilpydhsrvkLaalkdesdtdyinanyipgynsp-reyiatqGPlpetvddfWrmvwekkssiivmltqlvEkgkekceeYWPad

RgQPMVHGALSLALSSVRSTETHVERVLSLQFRDQslKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYlHQRPLHTPIIVHCSSGVGRTGAFALLY
 .|...| ... | . ......| | .... ...  ||.. ..|| .||. | |.... ||.|...|. .  .... ..||.|||| ||||||.|  |  
e-epvlyGdikvtllaekeldewvirefkiekgke--krkvrqyhftsWpdhgvPektktlldfvrtvreai-ekkaskkPivvHCsaGvGRtGtfiald

AAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVR
 .|..|. . . ..  .| ..|..|....| . .  | .|.... 
rllqaieendyv-dvfgvvaelReeRnllvqtekqyifiheclld

Phosphatase PTPN23.AA Subfamily.R_Anemone_2.PD 1195-1453 32 3.2e-55 178.6 In-house 6-261 (262) Show / Hide
Range on Protein: 1195-1453
Range on HMM: 6-261/262
Sequence Identity: 32% (85 aa)

WRELQDAQEHDARGrSIAIARCYSLKNRHQDVMPYDSNRVVLRSGK----DDYINASCVEGLSPYcPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVS
. .|. ..|.  .  . |.  .   |||......||. || |.  .     |||||. ..|        .||||||| |  ||| || ||. .|||||  
yerlsrseetsvtl-ksalepvnkaknryanilaydktrvklqmlegeegsdyinanyidGyrrk-kayiatqaPlpetiedfWrmvWeqnsavivmltq

EAEMEKQKVARYFPTErgQPMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAhyLHQRPLHTPIIV
| |  |.||.||.| .  ... .|.|   |..  .....| | ....  ... .| .   |. .||. |.|.|...|| ....|..   .|.. ..||.|
eeergkakvhryWPsk--gsrsygklvvelkeevelsdyvlrsfkvkrteeeeerqvrqfhytsWpdegvpesgaslldlvrqvek--aqqesgagpivv

HCSSGVGRTGAFALLYAAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHV
|||.|||||| |  . . .. ..| . . .. | |...|.||. |.| ||.|....  .    
hcsaGvGrtGvfiavdillerikaealv-dvfqtvkqlreqrnlmvqtkdqyefiydvlleal

Phosphatase PTPN23.AA Subfamily.N_Choan_1.PD 1215-1452 33 3.7e-54 175.0 In-house 24-260 (262) Show / Hide
Range on Protein: 1215-1452
Range on HMM: 24-260/262
Sequence Identity: 33% (79 aa)

RCYSLKNRHQDVMPYDSNRVVL----RSGKDDYINASCVEGLSPYcPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPtERGQP
||||..... ||  || .    .. . |||||. |.|..      .|||.|.| . ..|| || |||||.|||.  | | .| |  ||.| .  . .  |
denvlknrysnivayDatrvkvtpneenkntDyinanfvpgykge-keyiatqgPvPaslvsfWqmvweqkvsaivmvtreieagklkChryWP-dense

MVHGALSLALSSVRSTETHVERVLSLqFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHylHQRPLHTPIIVHCSSGVGRTGAFALLYAAVQ
 . .   | ....|..||...|  |... .|....|.. .||. | |.....|| | ..|.    ...  ..|...|||.||||||..  |  .|..||.
lklgdvtvkslseeekktyierkfkl-eresgetreveqlaytaWPdhGvPattkellefrkavlka--tkkktkaplvihCsaGvGrtGtyialDrlvk

EVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRH
 .  ... ..|. .|..|. |.|  .  .| | || .     
aveekaealdvkavvaelrkernlmvqtlvqyefvykavlda

Phosphatase PTPN23.AA Subfamily.N13.PD 1215-1451 34 5.7e-54 174.4 In-house 24-256 (259) Show / Hide
Range on Protein: 1215-1451
Range on HMM: 24-256/259
Sequence Identity: 34% (81 aa)

RCYSLKNRHQDVMPYDSNRVVLRSGKDdYINASCVEGL-SPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPM-V
.    |||...|.|||  || | .    ||||| ..          .|.| ||| |..|||.|| |||..||.|. .| | .| |  ||.|...... |.
kenkdknryrnvlPydetrvklgdegg-yinaslikvpvgedeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPerknkklkv

HGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAhyLHQrpLHTPIIVHCSSGVGRTGAFALLYAAVQEV
. | ..|  |   .. | | | ..  . .  | ..||.| .||. | | |. .|..|..||.   |..   ..||.||||.|.||.|..  ...... .|
snrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaelvqfvaevrl--lqt--dagPivvhcsaGiGrsGvlitidvvlgli

EAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVR
  . . .. ..||..|.||. ..| |    |.|.|..  
erdkef-dvkeivrklreqrqgvvqtkdqyifvykaile

Phosphatase PTPN23.AA Subfamily.N9.PD 1198-1452 32 4.4e-53 171.6 In-house 6-273 (275) Show / Hide
Range on Protein: 1198-1452
Range on HMM: 6-273/275
Sequence Identity: 32% (87 aa)

LQDAQEHDARGRS-IAIARCYSLKNRHQDVMPYDSNRVVLRSGK----DDYINASCVEGLSPYcPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEA
.| ..... |.   .  |. . |||..||. ||. ||.| . .     |||||. |.|       ..||| ||. |  |||.|| ||.| ||||     |
yadirnepveGtflasklranleknrytdvlcydetrvklakldedeasdyinanfvdGykqk-kafiatqGplkktvsdfwrmvweqevlvivmttrvv

EMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAH------YL----HQR
. . | ..|.|.|... . .| ||..  .|...| ...||| ..  ... .|...|  | .||. | |.| ..|| ....|.      .|    . ..  
ergrlkcgqywpleeessaefgdlsvsnveveveedykvrvleiknvkteesrkvthfqflswPdyGvPssaaslldvlekvrekqalavkelgdeskgh

PLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRH
 ||.||||.|.||||.|. |  .....|  . . .. . |...|.|| ...| .    ||| ||. .   
lsgPPivvhcsaGiGrtGtfitldiclarleevgtv-dvvetvkllrtqrafsiqtpeqyefcylavley

Phosphatase PTPN23.AA Subfamily.R_Anemone_1.PD 1199-1452 32 6e-53 171.2 In-house 7-256 (258) Show / Hide
Range on Protein: 1199-1452
Range on HMM: 7-256/258
Sequence Identity: 32% (82 aa)

QDAQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSG----KDDYINASCVEGLSPYcPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEM
|  .|...   ..|  ..   |||..|....|. ||||..     . |||||| ... .      .||||||. | .||| ||..|..||||| .  |.|
qrlkeikeeekevarkaenkkknryadivaldhsRvvLeklsndeesdYinasylrasdkt-rafiatqapleetvedFWrmvwqekigviVmLtnlieg

EKQKVARYFPTergQPMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHylhQRPLHTPIIVHCSS
|.|. .|.|.   ..  .| |.. | .       . | | |. .... .| .|..|| .||. ||.    .|.. ..|...   ... ..|..||||.||
ekkkchqYwPd---stekygelrvslrkkevfadyiirtlvlskkketeerevvqyhftvWpdkgvPqyatavLglrrkvqks---slagarpvvvhCsa

GVGRTGAFALLYAAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRH
||||||  ..| .. . . . . .. . |...|..| ||.| ||...||..       
GvgRtGaflvidamleqakkekvv-Difnyvkairedrphmvqtkeqyvfihlavlea

Phosphatase PTPN23.AA Subfamily.R_Sponge_2.PD 1210-1453 33 6.8e-53 170.9 In-house 18-261 (262) Show / Hide
Range on Protein: 1210-1453
Range on HMM: 18-261/262
Sequence Identity: 33% (81 aa)

SIAIARCYSLKNRHQDVMPYDSNRVVLRS---GKDDYINASCVEGLSPYcPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTE
|||  .    |||.....|||..|| ||.    . |||||| |.|.       .|||.||. |..||| || |.||| ||||.| .|.| |.|.|.. ..
siaklkenvgKnRfkeilpydmsRvrLrtdgskdsDYinAsfvdgykrr-kayiatqgPlketveDfWRmvweykvstivmltnleengkekcakYWPek

RGQPMVHGALSLALSSVRSTETHVERVLSLQFRDQS-LKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHylHQRPLHTPIIVHCSSGVGRTGAFALL
 .  |    .| . . .. .. | | |. ...|  .. . . || .||| . |.. . || .|..|. .  ...   ..|.|.|| ||||||.|  |.. 
vdeeveygkfkvtlkeeekladyiirklklskekssegeadvtqfhfvaWpehevPkdatsllelikrvlra--qkksgnkaitvvCsdgvgrtGtfial

YAAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHV
.. ..| . | .. .... .| .|  ..|.. .  |...|.   .   
dsvlerlkaeeei-dvfevlktlrtkriglvqdaaqYvfihdalleyi

Phosphatase PTPN23.AA Subfamily.N12.PD 1212-1453 30 3e-52 168.5 In-house 27-269 (270) Show / Hide
Range on Protein: 1212-1453
Range on HMM: 27-269/270
Sequence Identity: 30% (76 aa)

AIARCYSLKNRHQDVMPYDSNRVVLRSG----KDDYINASCVEGLSPYCpPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTER
. .     |||..|..||| .||.|.      ..|||||. ..| .  .   .|.|.||| |  ||| |. |..|...||.  | |..|.|.||.| | .
gekeenvkknrykDilPydksrvelskieeeegsdyinanfikgvegkl-eyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCeryWpeeg

GQPMVHGALSLALSSVRSTE-THVERVLSLQFRdqSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQrplHTPIIVHCSSGVGRTGAFALLY
... .|.....|.. . ..  .. | | ....  . .|..  .|.  ||. | | |...||..|..|. .  ..   ..|..||||.||||||.   .  
eeelefgefevtleeekavdddflirtLkveaq--kesrkvyqfhytaWPDhgvPssaksllelielvrelqese---daPlvvhCsaGvGrtGtiiaid

AAVQEVEAGNGIP--ELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHV
. . ..|..  .  .. .|| ..|.||. . | |   .. |.||.  | 
yvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv

Phosphatase PTPN23.AA Subfamily.N5_RR.PD 1218-1452 30 4.8e-50 161.5 In-house 24-263 (265) Show / Hide
Range on Protein: 1218-1452
Range on HMM: 24-263/265
Sequence Identity: 30% (75 aa)

SLKNRHQDVMPYDSNRVVLRS--GKD---DYINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQ--P
. |||.....| .  ||.|.|  ..|   .||||  . | .      |||| ||| | ||||.|.....|.|||||    |...|| |.|||....    
qtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntiadfWrmiyqeevqvivmltklkeanrqkcavyfPdaedyeis

MVHGALSLALSSVRSTETHVERVLSLQFRDQsLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSSGVGRTGAFALLYAAVQ
  .| ...  ... ... .  | |.|..  . ..||..|  .. ||.   ||....||....||.    ..    .|..||||.|.||||.|     ||.
erygdveikveeiverndysvrklvlkyler-versvkhywytdWPdhksPddintlldlvleveesreeenaklaPvvvhcsaGiGrtGcfiaisiavr

EVEAGNGIPELpQLVRRMRQQRKHMLQEKLHLRFCYEAVVRH
.... . .  | ..| ..|..|  |.|..   .. ..|.. .
qlreeivvdvl-kivcnlrldrGGmvqtseqyelihralcly

Phosphatase PTPN23.AA Subfamily.RA.PD 1219-1453 32 3.6e-48 155.3 In-house 29-265 (266) Show / Hide
Range on Protein: 1219-1453
Range on HMM: 29-265/266
Sequence Identity: 32% (79 aa)

LKNRHQDVMPYDSNRVVLRS--G--KDDYINASCVEGLSPyCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTErGqPMVHG
|||  ...||| .||.|    |  . |||||| ..|        .|.| |.  |  ||| |. ||| . ||||    | ...| |.|.|.||  . .| .
kknrvvqilpydfsrvilsvkeGeeesdyinasfidGyre-kdkfiaaqGpkeetvedfwrmiweqksativmltelkerkeekcaqywpde-G-lvtyG

ALSLALSSVRSTETHVERVLSLQ----FRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHylHQRPLHTPIIVHCSSGVGRTGAFALLYAAVQ
 ...  .  .|.   | . ..     ...  .| .  .|| .|||.|.| ..  .|.....|..   .|.    ||.||||.||||||.|  | | .. |
eirvevkdetvledytvrdflvtqlpdatrekksrlvrqfhftswpevGvpaegkGmlkllkkvkkl--qqqsanhpivvhcsaGvGrtGtfivldavle

EVEAGnGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHV
.|  .. .. . |.|.|.|| .|.| .    |.|...  ..  
rvkae-rkldvfeavkrlrlqrpqmvqtleqyefiykvlleyi

Phosphatase PTPN23.AA Subfamily.N6.PD 1196-1453 29 4e-48 155.3 In-house 19-294 (295) Show / Hide
Range on Protein: 1196-1453
Range on HMM: 19-294/295
Sequence Identity: 29% (80 aa)

RELQDAQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSG-----KDDYINASCV--------EGLSPYCP----PLVATQAPLPGTAADFWLMVH
|||  . ..   |. .     . ||| ....|.| .||.|. |      .|||||. .        .| .. .       .||| .|. |.||| ||...
eelqkqeseklysrkegekienkeknryknilPfDhtrvilkdgepsvpgsdYiNanyirlpkaskssgenveseehqkryiatqgcLkdtvsdFWrmvw

EQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMvHGALSLALSSVRSTETHVERVLSLQFR-DQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAH
.  ||||.  | |  |.| |||.|.|. .   .| ...   | .||.. . | .|.. . ... .|.....|| .||. | |.|. .| |...|.... .
qensrvivmttkevergknkCarYWPdeetkke-tGvitvtsisEkstadYtlRefsvshkdkdkeareifqyhfkaWPdhgvpkdpgvvlnfledvnkk

YLHQrPLHTPIIVHCSSGVGRTGAFALLYAAVQEV---EAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHV
    . ||.||||.|.||||.| .. . .. .    .   | .. . ....|.||  ..| .  ..| | ||..     
qeel-ekagpivvhcsaGiGrtGtfividivlkiieqsgldvdi-disksikdvrsqrsglvqteaqykfvykavqfyi

Phosphatase PTPN23.AA Subfamily.R_Ecdysozoa.PD 1217-1451 30 9.9e-47 150.4 In-house 27-266 (269) Show / Hide
Range on Protein: 1217-1451
Range on HMM: 27-266/269
Sequence Identity: 30% (73 aa)

YSLKNRHQDVMPYDSNRVVLRS----GKDDYINASCVEGLSPYcPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQkVARYFPTErgQPMV
||||..|....|..||.|.      . |||||| ..|        .| |.|. .|. ||| |. ||.| .||||  . |.... .|.|.| |  . . .|
nalknryedikafDktrvkLkkingkedsdyinasfikgykek-kkfiaaqdPveatigDfWrmiaeqevtlivmlsnlteknrk-cakyWpie--devq

HGALSLALSSVRSTETHVERVLSLQFRD---QSLKRSLVHLHFPTWP-ELGLPDSPSNLLRFIQEVHAHYLHQ--RPLHTPIIVHCSSGVGRTGAFALLY
 .   | | .... ...| |..   .      .| .|  .. .|. .   |...  ||..|..|. .| ..     ..||.|||| ||||.| |  |   
ygdilvklvseekhsdyiireldvskkkeesvedsrkvvqysytgWksDskvPevargllklieqvrelyklnklsgsrsPivvhCsaGvgrsgifvald

AAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVR
.|...| . . .. . |. .|.||. ..|      |.| |..   
lllqqlkaedkv-difetvkkLrsqrnllvqsleqyvflyralad

Phosphatase PTPN23.AA Subfamily.RG.PD 1192-1451 26 1.3e-45 147.0 In-house 3-261 (264) Show / Hide
Range on Protein: 1192-1451
Range on HMM: 3-261/264
Sequence Identity: 26% (71 aa)

DTVWRELQDAQEHDARgRSIAIARCYSLKNRHQDVMPYDSNRVVLRS--GK--DDYINASCVEGLSPYcPPLVATQAPLPGTAADFWLMVHEQKVSVIVM
.  ..|.|  ...| .  . . ... . |||. ....... || |..  ||  .|||||| ..|        ..|| ||. |. ||| |. |.....|||
eeqfeeiqklkpkdie-aesskkeenkeknReinivaversRvklsplpgkdgkDYinAsyidGyrrs-keyivtqgplketiedFWrmiWehnaqiivm

LVSEAEMEKQKVARYFPTErGQPMVHGALSLALSSVRSTETHVERVLSLQFR--DQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVhahYLHQRPLH
| .  |  ......|.|..  .|.  .||.. | |   ... . | ..|. .  |....|   ..|...||. | |.|  . ||..        ..    
ltdldekgrrdedvyWPkk-deplelealkvtllskeklskytvrdfvlkntkddkekervvrqyhytkWPdmgsPestlfvlifvkke---eaankeea

TPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVR
||.||.|.||||.| .  | . .|..|. . . .. |.....|..| ......   .| |.|..  
GPivvhdsaGvgragtyialdtllqqlekeeav-nvyqvlklirakRpglvtteEqyvfiydalle

Phosphatase PTPN23.AA Subfamily.N_Choan_2.PD 1220-1453 28 1.5e-45 146.5 In-house 24-265 (266) Show / Hide
Range on Protein: 1220-1453
Range on HMM: 24-265/266
Sequence Identity: 28% (68 aa)

KNRHQDVMPYDSNRVVLRSGKDD----YINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGA
||..|..|    ||.| . ..|    ||||  |.| .      .|...||| |  .|| |. |.||. |||.    |  ..| .||.|.|... .   . 
lnRyndiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvklad

LSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPS------NLLRFIQEVHAHYLHQRPLHtPIIVHCSSGVGRTGAFALLYAAV
 ..  .. .. ..  ..  |. . .. .|.||| .. |||. | | ..       .||. ...|......  . |..|||| |||||| . ..  ||. .
gkikvlalseekeegyiltrlrlekkgetrrlvHfwyntWpdhgvpreedsslstdqllkmlravrrvrkeldkae-PllvHcsaGvgRtGtliaiDiav

QEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHV
|  . . .. ......|..|  ..|   . .. |.||| ..   
rlLeetkkv-dvlaiieelRkdRmalvqhpeqyellykavveya

Phosphatase PTPN23.AA Subfamily.N14.PD 1217-1453 30 3.7e-45 145.4 In-house 26-274 (275) Show / Hide
Range on Protein: 1217-1453
Range on HMM: 26-274/275
Sequence Identity: 30% (74 aa)

YSLKNRHQDVMPYDSNRVVLRSGKD---DYINASCVE-GLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTE--RGQP
|||..||.||. ||| | . |.   .||||| ..  ..      ...|.||. |  ||| || ||.|..|||| .| |  |.|  .|.| .  . . . .
naeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfwqmvweqgvqlivmlteeeedgkeksfkylPkleskkkt

MVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRP-------LHTPIIVHCSSGVGRTGAFA
|   .    ...... . . | |..   . .|...|| .  ||. |.|. ....| |..||..   .           .|..|||| ||||||   |   
vefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsfLeevqsvrrktnsevesvkeskPPvlvhCsaGvGrtGvli

LLYAAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHV
 .. .| .. | .... ..|.|.|| ...|     .| |.......    
lsdlliatlehneei-dikkvlarLrkqrmllvqtlaqykfvykvlikyl

Phosphatase PTPN23.AA Subfamily.N1.PD 1220-1451 32 6.4e-45 144.8 In-house 31-265 (268) Show / Hide
Range on Protein: 1220-1451
Range on HMM: 31-265/268
Sequence Identity: 32% (75 aa)

KNRHQDVMPYDSNRVVLRSGKDDYINASCVEgLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQ-PMVHGALSL
.||..|| |||  |..|.... |||||| || |       . || ||| ||  || || ||.   ..||    | ...| | |.|.|. ...    .| .
lnryrdvspydhsrikleradvdyinaslve-leeakrrYiLtqGPLphtadHFWqmvWeqnskavimLnkvvEknqikCaqywpqeeeeaellleetkl

ALSSVR--STETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQrPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGN
  ..   .. .. | | |.  ...  | ..| |. |||..|.|.||. .|.|...|.   . . . ..|...|||.|.||.|...|. . . |.|. .  
kvkliseerksyflvrlleLedletqetreilhfhyttwpdfgvpespaafLkfLfkvresgsLs-sdvgpavihCsagigrsgtlslvdtclveiektg

G--IPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVR
   .. . .  .|..|  ..|    ||| | |..   
dlnavdikkvLlelRkyRvGLiqtpdqLrFsyiaile

Phosphatase PTPN23.AA Subfamily.RN.PD 1193-1453 34 3.6e-44 142.1 In-house 4-263 (264) Show / Hide
Range on Protein: 1193-1453
Range on HMM: 4-263/264
Sequence Identity: 34% (90 aa)

TVWRELQDAQeHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRS----GKDDYINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVML
|  | . .  . . ...| |  .  |||...|.||| .|| |..     |.|||||| .    |  |  .|||.||. | |||| || ||| |||.| . 
kewealcaye-aepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplsstiadfwqmvweqGvvvivnl

VSEAEMEKQKVARYFPTErGQPmVHGALSLALSSVR-STETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYlhqRPLHTP
.| . ....||.| | |.  |...  . | |    .. .. | . |.  ..|  |..  .|| .||| | | |. .|| |. |   |   |   .||.||
trleeegvkqckrywpde-Gse-vyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksy---rGrscp

IIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHV
||.|.||||.. |.   .. .  |    ..   .  .|.||..... |  ..|.. ||.. |    
ivvhcsdGaGrtGvyilidlvlerllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev

Phosphatase PTPN23.AA Subfamily.RK.PD 1206-1451 26 5.9e-41 131.5 In-house 18-264 (267) Show / Hide
Range on Protein: 1206-1451
Range on HMM: 18-264/267
Sequence Identity: 26% (66 aa)

ARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGK---DDYINASCVEGLSPyCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSE-AEMEKQKVAR
.   .||       ||| .|...||  .|.| | .    |||||. ...        ..|| ||. | .||| .|.... . ||||     |. |  .|.
sedcdiakkdrnreknrsmdilaydrslvflisvdgdssdyinaalidsykr-paafivtqgPlqetvkdfWrlvydencasivmlteldvevgrvkClk

YFPTERGqpMVHGALSLALSSVRSTETHVERVLSLQF--RDQSLKRSLVHLHFPTWPEL-GLPDSPSNLLRFIQEVHAHYLHqrPLHTPIIVHCSSGVGR
| .    . .| . . | ..   .  | |.....   | |. .| . ...| .|||  . |.|   ||..|..|...  .. .|.|||..| ||.|.|  
yWPedte--vrygdikvelveaeldadlvvrifrveklargqeeirevrqfqflgWpeyrdvPvskrsllklirrvkksqee--eeeGrivvhClaGaGr

TGAFALLYAAVQEVEAgNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVR
.   .. .|  .|. .. . |. .|...  |.. .   .|.|....       
sGtfiaidivlemier-egvvdvfnavktlrnrkvnmveteeqykfvydvile

Phosphatase PTPN23.AA Subfamily.N_Nematode_5.PD 1220-1453 29 2.6e-40 129.3 In-house 28-257 (258) Show / Hide
Range on Protein: 1220-1453
Range on HMM: 28-257/258
Sequence Identity: 29% (68 aa)

KNRHQDVMPYDSNRVVLRSGKDDYINASCVEgLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVaRYFPTERGQPMVHGALSLA
|||..||. .|..|| |  ..|.||||| .. |      |. || ||| |..||| ||...|.  .|.||.. |.....|.||.| |. . .| .     
knrskdvkilDetrVkltdeddsYinaskik-lddlekkliltQlPlpdteedFWrmvyqekitsvvllvedeelketav-sffpletgdylnlgkmfin

LSSVRSTETH-VERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLR-FIQEVHAHYLHQRplhTPIIVHCSSGVGRTGAFALLYAAVQEVEAGnG
 | . |..  | .. .   ..| .  . . |. ||..   ||. .....  |..|. ..  ..|..|....|.||.| |.|| .|......|   |.. .
nrkvevkedekkeytvevlpegcsesvfakvyhlttWkkkkvPdkvkkvikraiekvlskkqgkn---apvvvvsdlGlgRagtflllsvaieqlnng-k

IPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHV
... .|.|| .. ..  .  . |.||. ..      
epnideilkkirsqRpgavesliqyasvyaavldyi

Phosphatase PTPN23.AA Subfamily.N_Nematode_1.PD 1219-1446 31 4e-38 122.3 In-house 28-257 (265) Show / Hide
Range on Protein: 1219-1446
Range on HMM: 28-257/265
Sequence Identity: 31% (74 aa)

LKNRHQDVMPYDSNRVVL--RSGKDDYINASCVeGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGAL
|||..||   | |||.|   .   ||| |  | | .     .. .||||  | |||| ||  .||  ||||    |. |.|| |||...|. ..      
dknrykdvgcldknrvklaeeplpsdyihanyv-gtptnpkrficaqaPldktiadfwymvlqekveaivmlckliekgkkkcaeyfpakegeklefkek

--SLAL---SSVR---STETHVE-RVLSLQFRDQsLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVhahylhqRPLHTPIIVHCSSGVGRTGAFALLYA
 ...   ..|.   ..|  ..  ||....  .  .|.. |...  ||. | |      | ....|       |. ..||.||||.|.||||.   .   .
gqkitvenslgvkkleedeevikvtvlevegaGe-ktrkvthyqWtdWPdrGvPpadlaalelleav-------rgskgPivvhCsaGiGrtGtivaiey

AVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCY
... .|. |.. ..||...|.||.. .|      | .  
ildkllegkqiedmeklvkkireqrnysiqtdaqylfvh

Phosphatase PTPN23.AA Subfamily.RC.PD 1218-1451 30 4.6e-36 115.6 In-house 27-285 (288) Show / Hide
Range on Protein: 1218-1451
Range on HMM: 27-285/288
Sequence Identity: 30% (78 aa)

SLKNRHQDVMPYDSNRVVL---------------RSG--------KDDYINASCVEGLSPyCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEM
|||. ||.||| ||| |                |           .||||| ...       ..|.| ||  |  ||| |..|.|| |||||    | ..
ksknrysdvlpydynrvelkhelemskesehdsdessdddidseegskyinasfidsykk-pekyiaaqGplketvddfwrmiferkvkvivmltelkeG

EKQKVARYFptERGQpMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRP-------LHTP
.| |.|.  | |.   .| . . |     . ... |.| |. . .   | .... . .|.. .||. | .||..|| |. ...|          ||..||
drekcaeyw--eeGk-rayGdvevdlkdtdkssdyilrklelvnkkrkdsrevtqiqytswsveqlpeepkellkliqvvkqklpqkrsseafknfkstp

IIVHCSSGVGRTGAFALLYAAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVR
|..|..||| |  | | .. .|| . . .. |.|...|..|  |.. .    . |...|     
llvhcrdGsqrtGifiallallesleaeekv-dvfqvvkklrkarplmvsveeqyillydvlve

Phosphatase PTPN23.AA Subfamily.N_Nematode_4.PD 1216-1446 27 1.5e-34 110.7 In-house 25-256 (264) Show / Hide
Range on Protein: 1216-1446
Range on HMM: 25-256/264
Sequence Identity: 27% (65 aa)

CYSLKNRHQDVMPYDSNRVVLRSG--KDDYINASCVEglSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVH
| |||..|..  | .||||.    . ||| || .    |     ..|| ||. | .||| ||...|..|.||| .  | ..| |||.| . .. ...|  
knsdknryadilcidetrvvlknrdpdndyihaswmr--mPdkfryistqGPlketlsdfwhmvytekiavvvmlcdlieegvekcaryypeksekvvkf

GALSLALSSVRST--ETHVERVLSLQFRDQSLKR-----SLVHLHFPTWPELGLPDSPSNLLRFIQEVHAhylhqRPLHTPIIVHCSSGVGRTGAFALLY
 . |   .       . . | .   .....       . |.... |..   |  .  ...... |.      .. ..||.||||.||||| ..  .. | 
GkyritlvekkeeviadvilnslkvtntekkkdapseplvvkhvqvdwwrdqvaPldaapviklykavkk-----kkkekPivvhcsaGvGrtatlvGid

AAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCY
. .   . | |. ..||..|. | . .| .|   | .   
yatirirensei-evldivrelramrlkavqshlqflfll

Phosphatase PTPN23.AA Subfamily.N_Nematode_6.PD 1215-1449 29 2e-34 110.3 In-house 22-248 (253) Show / Hide
Range on Protein: 1215-1449
Range on HMM: 22-248/253
Sequence Identity: 29% (66 aa)

RCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEgLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHG
.. .||....  .|  |..|   .| || |. |. .|.    |. ||||| ||  .|| |.  . |  ||||.   |  |.| |.|.. . |. .. . |
lkfkdrnrytniqCcdagrlkladdedfyihanlvk-istkprrlictqaplegtieefwkmilssgveyivmlcelvekgkeksaeylsdkvGdarkit

ALSLALS-SVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHylhqrplHTPIIVHCSSGVGRTGAFALLYAAVQEVE
   .  . .. .  . |.|    ..   .  . |.|.  ||. |.|||    ||... |. .. ||.||||.||||||..||.  ... .   . . ...
klctvikigrkdidkilvrslkrivkagdeevivkhihWanWPdhGvPdsflsalrllsvvkkd-------kkPivvhCsaGvGrtGtlaliliilealr

AGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAV
.|. ..|..| . .| ..   . .  |         
lpdfq-gvkdllvklreerfravqtevqylyalrcv

Phosphatase PTPN23.AA Subfamily.N20.PD 1220-1450 33 2.6e-34 110.0 In-house 29-253 (257) Show / Hide
Range on Protein: 1220-1450
Range on HMM: 29-253/257
Sequence Identity: 33% (77 aa)

KNRHQDVMPYDSNRVVLRSGKdDYINASCVEGLSPYC-PPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSL
|||..|..|||| || |   | |||||| .  .        .||| ||  |  ||| || |..  || |.  | |    |. .|.|    .|.    . .
knryrdilpydstrvplgksk-dyinasyirivncgeeyfyiatqgpllstiddfwqmvlennsnviamitreieggiikcyhywpislkkplelkhfrv

ALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQevhahYLHQRPLHTPIIVHCSSGVGRTGAFALLYAaVQEVEAGNGI
 |   .  .  . |.. .  .     .|. .|.|  ||. | | |  .....|.     | ..  |  |..||||.|.|||||  .   |      |   
flenyqilqyfiirmfqvvekstgtshsvkqlqftkwpdhgtpasadsfikyir-----yarkshltgpmvvhcsagigrtgvflcvdv-vfcaivkncs

PELPQLVRRMRQQRKHMLQEKLHLRFCYEAVV
.. ..| .||.||  |.| | . .|||. |. 
fnimdivaqmreqrsgmvqtkeqyhfcydivl

Phosphatase PTPN23.AA Subfamily.R_Nematode_3.PD 1217-1452 26 9.8e-34 108.0 In-house 23-265 (267) Show / Hide
Range on Protein: 1217-1452
Range on HMM: 23-265/267
Sequence Identity: 26% (65 aa)

YSLKNRHQDVMPYDSNRVVLRS----GKDDYINASCVEGLSPYCppLVATQAPL--------PGTAADFWLMVHEQKVSVIVMLVSEAE---MEKQKVAR
.. ..|...|. . ..||||       |||.|.|. ||  .  .  |. ||.|.          |   || |....|| ..||| .  |    |..| ..
kvsedrrvevpllektrvvLkgygkrfkddfihAnvvecpnglk--lIltqsPqkkdkekkkkstieKfwwmieqekveqvvmlcdfveedgeeeekcse

YFPTERGQPMVHGALSLAL-SSVRSTE-THVERVLSLQFRdQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHylhqrplHTPIIVHCSSGVGRT
|.|.. .. .  . .|.   .  . ..   ..| | ..|  .  .    ||..  |.||. |..| ..|  |. |..         ||..|||| |..|.
Yypekvdgelkfegvsvkctdikkelsedvekrtlvvtfe-kkkeftvthllykgWkelnapeepkealelikfveks-------ktpvvVHCsdGisRs

GAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRH
...|    ..| .   .|  .| .|.  .|.||.. .|..| | |...     
atlaaielgyqliikskgkldllslikelrkqRagaiqtelelafvilgilkl

Phosphatase PTPN23.AA Subfamily.R_Nematode_2.PD 1220-1444 32 2.4e-33 106.6 In-house 32-251 (261) Show / Hide
Range on Protein: 1220-1444
Range on HMM: 32-251/261
Sequence Identity: 32% (73 aa)

KNRHQDVMPYDSNRV-VLRSGKDDYINASCVEGlSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSL
|.|..||   .. .| |.  ||   | |  |.  .      .|||.||  |  ||| ||  .||  ||||    | ||.| ..|||.| .| .. | .|.
khRypdvPCkpetavevivdgkrvpihanwvpt-agnpkrfiatqgPlentsedfWamviqekvekivmlcqkvekekekceeYfpletsqkldlgrfsi

ALSSVRSTETHVERVLSLQFRDQSL---KRSLVHLHFPTWPELGLPDSPsnllrfiQEVHAHYLHQRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAG
.  |...  ..   . .|.  |..     |.. |. .  ||. |.|.|        .|...  . ||.||||.|.|||.||       .|||| . | ||
ktvsaekilkdeiekrtlkvedstgkfatrtvthyqyeeWpdrgvPksh-------aelfeLlelvkksekPivvhCsaGiGRtmafigteylarevead

NGIpELPQLVRRMRQQRKHMLQEKLHLRF
 .... .|..| . .|..  | .      
pti-eltealkelrehRwkgiqtesqlyw

Phosphatase PTPN23.AA PTPc_motif 1346-1451 30 5.2e-32 113.57 SMART 1-92 (92) Show / Hide
Range on Protein: 1346-1451
Range on HMM: 1-92/92
Sequence Identity: 30% (34 aa)

SLVHLHFPTWPEL-----GLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKL
.. |.|...||.      |.|.  ...|.||..|..          ||.|||| |.|||| |.... ..|        .   |.|..||.|| .| | . 
TVHHYHYTNWPDHVEKDSGVPE--DSILEFIRHVRK----------PIVVHCSAGCGRTGTFCAIDMMMQQ-------VDIFQTVKEMRKQRPGMVQTEE

HLRFCYEAVVR
  .|||...  
QYIFCYRCILE

Phosphatase PTPN23.AA Subfamily.N_Nematode_egg.PD 1212-1453 26 2.7e-20 64.0 In-house 21-256 (257) Show / Hide
Range on Protein: 1212-1453
Range on HMM: 21-256/257
Sequence Identity: 26% (66 aa)

AIARCYSLKNRHQDVMPYDSNRVVL--RSG--KDDYINASCVEGlSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMekQKVARYFPTER
|..  |  | | . |   .| || |  | |   ||.| |  |.|  |    .. .||||  |  ||| ||...||  |||| |  |   ..   |.|   
aasdnylekarskrvhckessrvklelrrGqylddfihanrvkG-kpllnefilaqaplkntvedfwrmvfqekvqyivmltsakes--erceyywpkae

GQPMVH--GALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIqevhahylhqRPLHTPIIVHCSSGVGRTGAFALL
 ...|   |.| .    | |    . ||  |.      .   .      .  |.   ||..|| .          | | .|..|..  || .....  . 
seslvtvpGslrienlkvdskadplfrvtklklvGgddeelflehwqgdvnylsdvysplrvlrkl----------rnlskpvvvqdilGvskaatlvai

YAAVQEVEAGNGIP-ELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHV
 |. ..  |      . . |  .|..|.  ..  |   ||  |....  
eiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlffi

Phosphatase PTPN23.AA Subfamily.N_Fungi_PTP1.PD 1219-1305 34 4.9e-17 53.0 In-house 47-150 (343) Show / Hide
Range on Protein: 1219-1305
Range on HMM: 47-150/343
Sequence Identity: 34% (35 aa)

LKNRHQDVMPYDSNRVVLR------------SGKDDYINASCVEGL--S-PYCPPL--VATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVAR
|||.....||. .|| |.               .|||||. ..    |    |    .||||||| |  ||. .. . ||||..| |. |.. .|. ||.
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YFPT
.   
YWqe

Phosphatase PTPN23.AA Subfamily.N_Nematode_eak.PD 1220-1362 28 8.1e-13 39.4 In-house 29-171 (281) Show / Hide
Range on Protein: 1220-1362
Range on HMM: 29-171/281
Sequence Identity: 28% (41 aa)

KNRHQDVMPYDSNRVVLRSG---KDDYINASCVEgLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERgQPMVHGAL
.||  ...|.| . | | |    .| ||||| .| .|      . | ..       || || |||   ||.|. . |...|  .||| .  . . .| | 
rnrvvkivpqdrylvrltssqlnrdGyinaslae-fsevGrkyiltGiasedkvfafwqmvleqkspaivqlledveekleksdkyfpdkt-evlkyGil

SLALSSVRSTETHV-ERVLSLQFRDQslKRSLVHLHFPTWPELGLPD
.   .    .  .  | | |.  ..     . | ..  | |. ||  
dverkeyavkrniletrllilrkGne--thrvlhykvfGwtettlpk

Phosphatase PTPN23.AA Subfamily.N_Fungi_PTP1.PD 1347-1449 27 5.5e-10 29.8 In-house 215-338 (343) Show / Hide
Range on Protein: 1347-1449
Range on HMM: 215-338/343
Sequence Identity: 27% (30 aa)

LVHLHFPTWPELGLPDSPSNLLRFIQ-------EVHAHYLHQRPLHTPIIVHCSSGVGRTGAFALLYAAVQE-------------VEAGNGIP-ELPQLV
. .|..  |..|.|   | ..|. ..       .  |.   .    .||.||||.|||||| .  |   .....  . .   . ..| ..|.||  | |.
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

RRMRQQRKHMLQEKLHLRFCYEAV
.    |.|||.             
nelrkqrismvqnldqfifiYeal

Phosphatase PTPN23.AA Family.DSP.PD 1324-1408 17 1.6e-06 18.8 In-house 127-208 (387) Show / Hide
Range on Protein: 1324-1408
Range on HMM: 127-208/387
Sequence Identity: 17% (15 aa)

RSTETHVERVLSLQ-FRDQSLK-RSLVhlhfptWPELGLPDS-PSNLLRFIQEVHAhYLHQ--RPlHTPIIVHCSSGVGRTGAFALLYAA
|  | ....|.  ..|  |  .          .....|. ...| ......   ....  .. .  . |||  |.||.|     |     
wlkelgvtkivnltddkpqftkelgik------ylripidDhnapplenlfekaid-fieegnds-kgvVlVHCkaGkgRsgtliiaYlm

Phosphatase PTPN23.AA Subfamily.N_Nematode_eak.PD 1374-1453 22 2.7e-06 18.0 In-house 201-280 (281) Show / Hide
Range on Protein: 1374-1453
Range on HMM: 201-280/281
Sequence Identity: 22% (18 aa)

VHAHYLHQRPLHTPIIvHCSSGVGRTGAFALLYAAVQEVEAG-NGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHV
.  .| |  | ..|||  .. |  |.|.| ..   .. ...  .    . .|. .....|.|    .|.  | ||.|. ..
tlkkyihtppsfapii-qsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyl

Sequence
Name Sequence Type Origin Length Description Download
PTPN23.AA Protein None 1636 None Fasta, JSON
PTPN23.NA RNA None 4908 None Fasta, JSON
PTPN23.AA.PD_1190-1454 Protein Phosphatase Domain None 265 None Fasta, JSON