Gene PTPN3
PTPN3
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of PTPN3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| FERM | PTPN3.AA | B41 | 25-222 | 32 | 2.8e-76 | 260.64 | SMART | 1-232 (232) | Show / Hide |
Range on Protein: 25-222 Range on HMM: 1-232/232 Sequence Identity: 32% (75 aa) TRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGV--TEKEYFGLQHDDDSVDSPRWLEASKAIRKQLKG---GFPCTLHFRVRFFIPD----PN .. .. |...|.|| ...|.| . |||.|.|.| .|.|. .|..||||. .|. .| ..||. .| |.|| . . |.||||||.|..|| || SPKPRFCRVYFMDGTTLEFEVDSSTTGQDLCDHVCRHCGISPREHWYFGLWYEDPHED-RHWLDHWKTIMKQDVKWHKSEPWTLHFRVKFYPPDWHGFPN TLQQEQTRH-LYFLQLKMDICEGRLTCP-LNSAVVLASYAVQSHFGDYNSS--------IHHPGYLSDSHFIPDQ---------------NEDFLTKVES .||.. ||. ...||.. || .||..|| . .. ||...||...|||... | ..|.|. .|.|.| .... .. . QLQEDPTRYNYFYLQCRHDILQGRHPCPHEEECLQLAALQVQIEYGDYDPEETNNKKMTKHVQKYKSYKRFLPKQWIDSIKQSFMHYQMHHKEWRKRIME LHEQHSGLKQSEAESCYINIARTLD-FYGVELH .| .|.|... ||. |..|..... ||||.. WHKNHCGMTPEEAKLKYLQICQRWPPMYGVEHF |
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| FERM | PTPN3.AA | FERM_M | 113-222 | 23 | 1.5e-43 | 150.58 | Pfam | 1-171 (171) | Show / Hide |
Range on Protein: 113-222
Range on HMM: 1-171/171
Sequence Identity: 23% (41 aa)
DPNT-LQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFG-DYN-SSIHHPGY-LSDS-------------------HFIP-----------
|||. .|.| |||...||.| ||.|||..|. |. ||.|..|..|| ||| .. | ..| .. ...|
DPNRDIQDEVTRHQFYLQAKWDILEGRYPCSEEEALMLAAYQCQIEFGSDYNPPQKHKSDYMEKEWWEQQEGMEVWLRCDNEQQERYWPAHCRLASKGRT
--------------------------DQNEDFLTKVESLHEQHSGL-KQSEAESCYINIARTLDFYGVELH
..... ... .|..|.|. ...||. .||.|......|||...
MADSSYSEVSIRINPHCYVSPWYCKKMKQKQWEQRILEQHKNHRGMCSPEEAMLQYIQICQRWPMYGVHFF
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| FERM_C | PTPN3.AA | FERM_C | 226-316 | 41 | 9.3e-39 | 139.72 | Pfam | 1-99 (99) | Show / Hide |
Range on Protein: 226-316 Range on HMM: 1-99/99 Sequence Identity: 41% (41 aa) DLHNLD-LMIGIASAGVAVY--RKYICT---SFYPWVNILKISFKRKKFFIHQR--QKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQ | .. | ...|....|. || .. .. ..|| .| |||||||||||..| ... |..||.. |.| ||| ||.|||.|||||.|| .. .. DKKGTDTWWLGVCAKGINVYQVQDNNKITPMNTFPWPEIRKISFKRKKFFIKLRDDPDEGEKYEHTHTFYMPNYRACKYLWKCCVEHHQFFRLRRPPDT |
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| FERM | PTPN3.AA | FERM_N | 33-111 | 36 | 1.5e-34 | 125.91 | Pfam | 1-93 (93) | Show / Hide |
Range on Protein: 33-111 Range on HMM: 1-93/93 Sequence Identity: 36% (34 aa) IHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQH--DDDSV--DSP-RWLEASKAIRKQLKG---------GFPCTLHFRVRFFI .|.||... .... | .|||.|.|.|..||. .|..|||||. ..|. . . .||...| |.||.| . ||||.|||.|.. VHLLDDTQLECTCDKKTTGQELFDQVCQHLNIRECWYFGLQFCKQNDKKEGNQHMHWLDPDKKICKQMKDGWKHKIKKKCPPCTLFFRVKFYP |
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| PDZ | PTPN3.AA | PDZ | 510-595 | 35 | 2.2e-25 | 89.53 | Pfam | 1-86 (86) | Show / Hide |
Range on Protein: 510-595 Range on HMM: 1-86/86 Sequence Identity: 35% (32 aa) LIRITPD-EDGKFGFNLKGGVDQK--MPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIR .... .. . |..||..||| ||. .....|...| |.|. . ....|||||. |||.||. .|||..| .|| |.. .|..|.|. QVTLEKQDKRGGLGFSIKGGNDQRHDQGIYISEVMPGSGAAERGGRIHEGDQIISINGQDIRNMTHDRAVQAIKGSKG---GEVHLTIQ |
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| Phosphatase | PTPN3.AA | PTPc | 645-903 | 36 | 7.6e-124 | 418.66 | SMART | 1-308 (308) | Show / Hide |
Range on Protein: 645-903 Range on HMM: 1-308/308 Sequence Identity: 36% (116 aa) TVLIQFEQLYRKKPGL---------AITFAKLPQNL--DKNRYK-DVLPYDTTRVLLQGNE---------DYINASYVNMEIPAANLVNKYIATQGPLPH . .|| |.| .|.. .| |..| | |||||| |...|| ||| |. .. |||||.|.... . ..||.||||||| GFWEEFERLQRMTPWDLMSNYDPCCSCTCACWPENREMDKNRYKCDIPCYDHTRVKLKPPPGESHCYEGSDYINANYIDGY----WRPKRYICTQGPLPH TCAQFWQVVWDQKLSLIVMLTTLTER--------GRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTI-AYVSREMLVTNTQT--------GEEHTVTHLQY |.. ||. ||.|| . ||||... |. || |||||||| |..|.....|.||. . |. |.. ||||.. .|..||||..| TIEDFWRMVWQQKCHIIVMLCNCMEKCTENRDQNGREKCHQYWPDE--PMTYGHITVTCKSEEKCPDDYTMRTFEVTNTGCNCKYSMACSETRTVTHYHY VAWPDHGVPDDSSDFLEFVNYVRSLRVDSE--------------------PVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQ .|||||||.....||.|...||. . |. |..||||||.||||........... |. . ...||..||.||..||| TNWPDHGVPESPDSFLDFIRQVRHWQSHSPNMYMNMVSSNSKYHHTCPTGPIVVHCSAGCGRTGTFCAIDIMCQQIEN---VDIFQIVKMMRNQRPGMVQ TSSQYKFVCEAILRVYE | ||.|....||.... TEEQYIFCYRCILEYIK |
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| PDZ | PTPN3.AA | PDZ | 519-598 | 24 | 1.3e-18 | 69.06 | SMART | 1-80 (80) | Show / Hide |
Range on Protein: 519-598 Range on HMM: 1-80/80 Sequence Identity: 24% (21 aa) GKFGFNLKGGVDQKMPLVVSRINPESPADTCI----PKLNEGDQIVLING-RDISEHTHDQVVMFIKASRESH-SRELALVIRRRA | .||...| ....|.. | .||. . ..| .||.|. .|| ... ||.|.| ..|...... ... |...|. GGLGFSIVG------GIFISSVVPGGPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG |
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| Phosphatase | PTPN3.AA | Subfamily.N3.PD | 646-903 | 66 | 1e-138 | 452.4 | In-house | 2-261 (261) | Show / Hide |
Range on Protein: 646-903 Range on HMM: 2-261/261 Sequence Identity: 66% (173 aa) VLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNE-DYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLT ||.|||.||||||||||. |..|.||.||||.|.||||.||| |. .| |||||.|||||||...|||.||||||||..|...|||.||.|| .|||||| vlaqfeelyrkkpglaisaarkpenlaknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGplaktakdfWqmvweqkstlivmlt TLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR-VDSEPVLVHCS ||.||||.|||||||.. | ...|.|...|..||.| .|| ||.......| ||.....|||.|||||||||||.||||||. ||.||...|||.||||| tlverGrvkChqyWPetedelefgefsvrcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCs AGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYE ||||||||...|||..|.|.. |.|||||||.|||||||.|||.|||||||||||..|| aGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtvsqykfvCeailkaye |
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| Phosphatase | PTPN3.AA | Y_phosphatase | 670-900 | 42 | 9.5e-115 | 392.31 | Pfam | 1-243 (243) | Show / Hide |
Range on Protein: 670-900 Range on HMM: 1-243/243 Sequence Identity: 42% (106 aa) NLDKNRYKDVLPYDTTRVLLQ-----GNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGR-TK-CHQYWPD-- |..||||||...|| ||| || .. |||||.|... . ..||.||||.|||.. ||. ||.|| . ||||... |.|| | ||||||| NKEKNRYKDIPCYDHTRVKLQPIPGDEDSDYINANYIDG---PYWNPKAYICTQGPMPHTIEDFWRMVWQQKCTCIVMLCNCMEMGRDEKTCHQYWPDNK PPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQT--GEEHTVTHLQYVAWPDHGVPDD-SSDFLEFVNYVRSLRV--DSE--PVLVHCSAGIGRTGVLV . |..|.|.. |.||... |. |.. ||| .. .|..||||..| .|||||||.. . ..|.|...||. . |. |..||||||.||||... EGQPMTYGDFQVTCVSEEHCPDYTVRTFEVTN-GDQKQETRTVTHYHYTNWPDHGVPESQPKSMLDFIRQVRKWQPNPDHGCPPIVVHCSAGCGRTGTFC TMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR ........ |.. . ..||..|| ||..|||| .||.|....|| AIDIMCQQMEHEGTVDIFQIVKHMRNQRPGMVQTEEQYIFCYQCILE |
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| Phosphatase | PTPN3.AA | Subfamily.N13.PD | 650-901 | 43 | 2.5e-83 | 271.1 | In-house | 6-257 (259) | Show / Hide |
Range on Protein: 650-901 Range on HMM: 6-257/259 Sequence Identity: 43% (109 aa) FEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIpaANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTER |..| || . . .| .| |||||..||||| ||| |... |||||...... . .|||.|||||.|.. |||.||.|| ..|.|.|. |. fkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdeggyinaslikvpv--gedeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekek GRTKCHQYWPDPP--DVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIG |. |||.|||. .. .. .... ..| |.. |.....|| . |.||..|.||||||| . ....|| .||.|.|. |..||||||||| gkvkchrywPerknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaelvqfvaevrllqtdagPivvhcsaGiG RTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV .|||.|..... | ||. .. .||||.|.|| .|||. || || .||| | rsGvlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev |
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| Phosphatase | PTPN3.AA | Subfamily.RB.PD | 656-902 | 36 | 1.6e-75 | 245.4 | In-house | 12-260 (261) | Show / Hide |
Range on Protein: 656-902 Range on HMM: 12-260/261 Sequence Identity: 36% (90 aa) KKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVN-MEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKC . |.. |....| .|||.. .||||..|| |. ..| .. |.| . || | ..|||||||||.| .||..||..| | ||||| | |.|..||. vgkdqavkaaeeavnraknrftnilpydhsrvkLaalkdesdtdyinanyipgynspreyiatqGPlpetvddfWrmvwekkssiivmltqlvEkgkekc HQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTgeEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVD---SEPVLVHCSAGIGRTGV .|||. . ...| ... ..|. . .| ||. ... .. ...|.......|||||||.... |.||. ||. . ..|..||||||.||||. eeYWPadeepvlyGdikvtllaekeldewvirefkiekgke--krkvrqyhftsWpdhgvPektktlldfvrtvreaiekkaskkPivvHCsaGvGRtGt LVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY ..... . |.| . . .| ..| .|...||| .|| |. |..|.. fialdrllqaieendyvdvfgvvaelReeRnllvqtekqyifiheclldll |
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| Phosphatase | PTPN3.AA | Subfamily.N_Choan_1.PD | 650-901 | 37 | 1.9e-75 | 245.2 | In-house | 6-260 (262) | Show / Hide |
Range on Protein: 650-901 Range on HMM: 6-260/262 Sequence Identity: 37% (95 aa) FEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNME-IPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTE .|.|. . . | .| ..| ||||... || ||| .. ||. |. |.| . .|. . ..|||||||.|.....|||.||.|| |.|||.| | yeklaeigvdntataskadenvlknrysnivayDatrvkvtpneenkntDyinanfvpgykgekeyiatqgPvPaslvsfWqmvweqkvsaivmvtreie RGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVtNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSE--PVLVHCSAGI |. |||.||||. .. | . .. .|| . |..|.. . ....||. .|..|.|.||||||||......||| . |.... .. |...|||||. agklkChryWPdenselklgdvtvkslseeekktyierkfkl-eresgetreveqlaytaWPdhGvPattkellefrkavlkatkkktkaplvihCsaGv GRTGVLVTMETAMCLTERNLPI-YPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV ||||. ....... |.... . ..|...| .| .|||| ||.|| |.|.. GrtGtyialDrlvkaveekaealdvkavvaelrkernlmvqtlvqyefvykavlda |
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| Phosphatase | PTPN3.AA | Subfamily.N14.PD | 646-900 | 37 | 1.4e-72 | 235.8 | In-house | 2-272 (275) | Show / Hide |
Range on Protein: 646-900
Range on HMM: 2-272/275
Sequence Identity: 37% (102 aa)
VLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQG----NEDYINASYVNMEIPAANlvNKYIATQGPLPHTCAQFWQVVWDQKLSLIV
| ..|.. .|. .. ||||.| .|||.||||||. .|| |. ...||||| ... . ... .||..||||..|. .|||.||.|...|||
vfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggke--rsyivaqgPleltvqdfwqmvweqgvqliv
MLTTLTERGRTKCHQYWPDP---PDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDS---
||| .| |..|...|.|. . ...| |... . . . ..... . . ..|| || ||||. |||||||.| ..||.|.. |.|.| .
mlteeeedgkeksfkylPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsfLeevqsvrrktnse
--------EPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
|||||||||.||||||.. . . | | | .....| || ..||| .||||| .....
vesvkeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLrkqrmllvqtlaqykfvykvlik
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| Phosphatase | PTPN3.AA | Subfamily.R_Anemone_2.PD | 649-899 | 36 | 4.1e-71 | 231.1 | In-house | 5-258 (262) | Show / Hide |
Range on Protein: 649-899 Range on HMM: 5-258/262 Sequence Identity: 36% (93 aa) QFEQLYRKKPG-LAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNME-IPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTL ..|.| |.. . .. | | | |||| ..|.||.|||.|| |. .. |.| . |. . ..|||||.|||.|. ||..||.|. ..||||| . eyerlsrseetsvtlksalepvnkaknryanilaydktrvklqmlegeegsdyinanyidGyrrkkayiatqaPlpetiedfWrmvWeqnsavivmltqe TERGRTKCHQYWPDPpDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR--VDSEPVLVHCSA .|||..|.|.|||. . ...| ... ..| . || |.. |..|.. || .| .| .|||.|||......|..|. |.. . .|..||||| eergkakvhryWPsk-gsrsygklvvelkeevelsdyvlrsfkvkrteeeeerqvrqfhytsWpdegvpesgaslldlvrqvekaqqesgagpivvhcsa GIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL |.||||| ..... . . . . ...|...|.|| .|||| .||.|. ...| GvGrtGvfiavdillerikaealvdvfqtvkqlreqrnlmvqtkdqyefiydvll |
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| Phosphatase | PTPN3.AA | Subfamily.N12.PD | 651-901 | 33 | 2.9e-70 | 228.0 | In-house | 13-268 (270) | Show / Hide |
Range on Protein: 651-901 Range on HMM: 13-268/270 Sequence Identity: 33% (87 aa) EQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGN-----EDYINASYVNMeipaANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTT .. |... . . .. ..| ||||||.||||..|| |. . .|||||.... .. .|||.|||||.| .||...|.......||. sekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdyinanfikg----vegkleyiaaqgPLpktlddfWrmiweknveivvmaCr LTERGRTKCHQYWPDPPD-VMNHGGFHIQCQSEDCTI-AYVSREMLVTNTqtGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV-DSEPVLVHC . | |..||..|||. . ...| |......|. . .. | . |.. .|...|. ..| |||||||| .. ||... ||.|. ...|..||| evelgkkkCeryWpeegeeelefgefevtleeekavdddflirtLkveaq--kesrkvyqfhytaWPDhgvPssaksllelielvrelqesedaPlvvhC SAGIGRTGVLVTMETAMCLT-ERNL--PIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV |||.||||...... . | .... . |.| ..| ||| .||| ||..| .|.. . saGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael |
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| Phosphatase | PTPN3.AA | Subfamily.R_Anemone_1.PD | 656-900 | 33 | 5.9e-69 | 224.1 | In-house | 11-255 (258) | Show / Hide |
Range on Protein: 656-900 Range on HMM: 11-255/258 Sequence Identity: 33% (83 aa) KKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQG-----NEDYINASYVNMEIpaanLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERG ... |. ..| .||||.|....| .||.|. . |||||||.. ...||||.||..|...||..||..| . |||||.|.| eikeeekevarkaenkkknryadivaldhsRvvLeklsndeesdYinasylrasd----ktrafiatqapleetvedFWrmvwqekigviVmLtnliege RTKCHQYWPDppDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSL-RVDSEPVLVHCSAGIGRT .|||||||| ..| .... .... |..|......... ||..|...... |||.|||. . .|.... |.. . ...||.||||||.|||| kkkchqYwPd--stekygelrvslrkkevfadyiirtlvlskkketeerevvqyhftvWpdkgvPqyatavLglrrkvqksslagarpvvvhCsaGvgRt GVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR . . ... . .. . ..|...| .|. ||||..|| |. .|.|. GaflvidamleqakkekvvDifnyvkairedrphmvqtkeqyvfihlavle |
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| Phosphatase | PTPN3.AA | Subfamily.N6.PD | 661-899 | 36 | 1.1e-68 | 223.1 | In-house | 31-291 (295) | Show / Hide |
Range on Protein: 661-899 Range on HMM: 31-291/295 Sequence Identity: 36% (93 aa) AITFAKLPQNLDKNRYKDVLPYDTTRVLLQGN------EDYINASYV--------NMEIPAAN-LVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTT . .. ..| .|||||..||.| ||| |. .|||||.|. . | .... ..||||||.|..| ..||..||... .|||.| . srkegekienkeknryknilPfDhtrvilkdgepsvpgsdYiNanyirlpkaskssgenveseehqkryiatqgcLkdtvsdFWrmvwqensrvivmttk LTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNT-QTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR---VDSEPVLVH |||. || .|||| . ..| .... ||. | .|. ||..|.. . |.... .... |||||||| |.. .|.|.. |.. ... |..|||||||| evergknkCarYWPdeetkketGvitvtsisEkstadYtlRefsvshkdkdkeareifqyhfkaWPdhgvpkdpgvvlnfledvnkkqeelekagpivvh CSAGIGRTGVLVTMETAMCLTERNLPIYPLDI---VRKMRDQRAMMVQTSSQYKFVCEAIL ||| .. ... . ..|.. ...|| ....| ||. .|||. ||||| |. csaGiGrtGtfividivlkiieqsgldvdidisksikdvrsqrsglvqteaqykfvykavq |
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| Phosphatase | PTPN3.AA | Subfamily.R_Sponge_2.PD | 652-900 | 34 | 7.8e-68 | 220.3 | In-house | 7-259 (262) | Show / Hide |
Range on Protein: 652-900 Range on HMM: 7-259/262 Sequence Identity: 34% (89 aa) QLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQG----NEDYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLT . .|. .. |||..|. |||.|..||||..|| |. . ||||||.|. . . . ||||||||..| . || .||..|.| ||||| |. ksveketefslsiaklkenvgKnRfkeilpydmsRvrLrtdgskdsDYinAsfvd----gykrrkayiatqgPlketveDfWRmvweykvstivmltnle ERGRTKCHQYWPDP-PDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQT-GEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDS--EPVLVHCS |.|. ||..|||. . .. | |... ..| . |. |.. ...... ..|..||. ..||||.|.||.|.. .||... |. . .| ... |.|| engkekcakYWPekvdeeveygkfkvtlkeeekladyiirklklskekssegeadvtqfhfvaWpehevPkdatsllelikrvlraqkksgnkaitvvCs AGIGRTGVLVTMETAMCL--TERNLPIYplDIVRKMRDQRAMMVQTSSQYKFVCEAILR .|.|||| ..... . .|... .. ......| .| ..||. .||.|. .|.| dgvgrtGtfialdsvlerlkaeeeidvf--evlktlrtkriglvqdaaqYvfihdalle |
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| Phosphatase | PTPN3.AA | Subfamily.N9.PD | 649-899 | 35 | 4.1e-65 | 211.5 | In-house | 5-271 (275) | Show / Hide |
Range on Protein: 649-899 Range on HMM: 5-271/275 Sequence Identity: 35% (95 aa) QFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNE-----DYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVML ..... .... .. .||. ||.||||.||| || ||| |. . |||||..|. . . .|||||||..|. ||..||.|.||| | . eyadirnepveGtflasklranleknrytdvlcydetrvklakldedeasdyinanfvd----GykqkkafiatqGplkktvsdfwrmvweqevlvivmt TTLTERGRTKCHQYWP-DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR---------- .|||| || |||| . .....| .... . ... .|. | . ..|..|.|. .||| |...|||.|||......|.... ||.. trvvergrlkcgqywpleeessaefgdlsvsnveveveedykvrvleiknvkteesrkvthfqflswPdyGvPssaaslldvlekvrekqalavkelgde ----VDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL .. |..||||||||||| ..|.. .. |. . . |...| ||| ..|| ||.| |.| skghlsgPPivvhcsaGiGrtGtfitldiclarleevgtvdvvetvkllrtqrafsiqtpeqyefcylavl |
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| Phosphatase | PTPN3.AA | Subfamily.RA.PD | 663-902 | 35 | 2e-62 | 202.5 | In-house | 20-265 (266) | Show / Hide |
Range on Protein: 663-902 Range on HMM: 20-265/266 Sequence Identity: 35% (89 aa) TFAKLPQNLDKNRYKDVLPYDTTRVLLQ---G--NEDYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQY |....| .|||. ..|||| .|| |. | . ||||||... . .|.||.|||. .| .||...|.|| . ||||| | ||...||.|||| rtankeenkkknrvvqilpydfsrvilsvkeGeeesdyinasfid----GyrekdkfiaaqGpkeetvedfwrmiweqksativmltelkerkeekcaqy WPDPpDVMNHGGFHIQCQSEDCTIAYVSREMLVT----NTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVD-S-EPVLVHCSAGIGRTGV | .. .| ... . | . .| |..||| .|. .. |. . . .||. ||| .. |.... |..|. . |.||||||.|||| ... wpde-GlvtyGeirvevkdetvledytvrdflvtqlpdatrekksrlvrqfhftswpevGvpaegkGmlkllkkvkklqqqsanhpivvhcsaGvGrtGt LVTMETAM--CLTERNLPIYplDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY ... . .|| | .. ..|...| ||. |||| ||.|. ...| . fivldavlervkaerkldvf--eavkrlrlqrpqmvqtleqyefiykvlleyi |
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| Phosphatase | PTPN3.AA | Subfamily.N5_RR.PD | 667-899 | 36 | 7.1e-62 | 200.7 | In-house | 20-261 (265) | Show / Hide |
Range on Protein: 667-899 Range on HMM: 20-261/265 Sequence Identity: 36% (88 aa) LPQNLDKNRYKDVLPYDTTRVLLQG------NEDYINASYVNMeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD .. . |||||..|| ...||||. . .|||| |. . . |.|||||||.| |.||.... .. ..||||| |.|. |.||..|.|| vfgsqtknryktilPnensrvllesessededssyinanyikG---ydeeskayvatqGPlpntiadfWrmiyqeevqvivmltklkeanrqkcavyfPd PPDV---MNHGGFHIQCQSEDCTIAYVSREMLVTNTQTgEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDS----EPVLVHCSAGIGRTGVLV |. ..|...|. .. . | |........ |..|.| | .|||| .||| . .|..|. |.. | ..||.|||||||||||. .... | aedyeiserygdveikveeiverndysvrklvlkyler-versvkhywytdWPdhksPddintlldlvleveesreeenaklaPvvvhcsaGiGrtGcfi TMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL . ... . | || ..| .| |||||.||... .|. aisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc |
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| Phosphatase | PTPN3.AA | Subfamily.N_Choan_2.PD | 670-900 | 36 | 1.1e-60 | 196.6 | In-house | 21-263 (266) | Show / Hide |
Range on Protein: 670-900 Range on HMM: 21-263/266 Sequence Identity: 36% (90 aa) NLDKNRYKDVLPYDTTRVLLQGNE-----DYINASYVNmeiPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDV | |||.|.|| .||| |. | |||| ||. . . .||||..|||| | .||...|..| . |||.| |.|.||.|| .||| |. nkrlnRyndiLPsPatRvrleeleedsataYinAnyvr---GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke ---MNHGGFHIQCQSEDCTIAYVSREMLVTNtqTGEEHTVTHLQYVAWPDHGVPDDSS------DFLEFVNYVRSLRV---DSEPVLVHCSAGIGRTGVL ...| .. .|| . |. ... ... ||.....| .|..||||||| .. . |. .. ||| ..||.|||||||.||||.|.. kvkladgkikvlalseekeegyiltrlrlek--kgetrrlvHfwyntWpdhgvpreedsslstdqllkmlravrrvrkeldkaePllvHcsaGvgRtGtl VTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR ...|..| |.. . .| |....| .| .||.. ||... .|.. iaiDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyellykavve |
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| Phosphatase | PTPN3.AA | Subfamily.RK.PD | 663-900 | 31 | 1.2e-59 | 193.2 | In-house | 22-264 (267) | Show / Hide |
Range on Protein: 663-900 Range on HMM: 22-264/267 Sequence Identity: 31% (78 aa) TFAKLPQNLDKNRYKDVLPYDTTRVLLQG----NEDYINASYVnmeiPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTL-TERGRTKCHQY ||...| .|||..|.|.|| ..| |. . |||||... . . ...|.|||||..| . ||..|.|.. . ||||| | .|.|||| .|||. diakkdrnreknrsmdilaydrslvflisvdgdssdyinaali----dsykrpaafivtqgPlqetvkdfWrlvydencasivmlteldvevgrvkClky WPDPPDVmNHGGFHIQCQSEDCTIAYVSREMLVTN--TQTGEEHTVTHLQYVAWPDH-GVPDDSSDFLEFVNYVRSLRVD--SEPVLVHCSAGIGRTGVL .| ..| ..... . . .|.| . |.. . | ..| ..|...||.. .||. .|... | . . . ...|||.|| ||.|. ... WPedtev-rygdikvelveaeldadlvvrifrveklargqeeirevrqfqflgWpeyrdvPvskrsllklirrvkksqeeeeeGrivvhClaGaGrsGtf VTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR .. . . ||. . .|...|.... ||.| ||||| ..|| iaidivlemieregvvdvfnavktlrnrkvnmveteeqykfvydvile |
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| Phosphatase | PTPN3.AA | Subfamily.RG.PD | 649-901 | 30 | 1.6e-59 | 193.0 | In-house | 5-262 (264) | Show / Hide |
Range on Protein: 649-901 Range on HMM: 5-262/264 Sequence Identity: 30% (78 aa) QFEQLYR-KKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQG-----NEDYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVM |||.. . |. . ....| ..| |||. ...... .|| |.. ..|||||||.. . ..||.|||||..|. .||...|.....|||| qfeeiqklkpkdieaesskkeenkeknReinivaversRvklsplpgkdgkDYinAsyid----GyrrskeyivtqgplketiedFWrmiWehnaqiivm LTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHT--VTHLQYVAWPDHGVPDDSSDFLEFVNY-VRSLRVDSEPVL | | |.|| ....|||. .... . .... |.. . |..|.... ||.. .|.. |....| |||.|.|. . ..| ||... . .. |..||.| ltdldekgrrdedvyWPkkdeplelealkvtllskeklskytvrdfvlkntkddkekervvrqyhytkWPdmgsPestlfvlifvkkeeaankeeaGPiv VHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV || ||.|... ..| . |.. . .......| .| ..|.|. ||.|. .|.| . vhdsaGvgragtyialdtllqqlekeeavnvyqvlklirakRpglvtteEqyvfiydallel |
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| Phosphatase | PTPN3.AA | Subfamily.N1.PD | 661-900 | 37 | 1.3e-58 | 190.0 | In-house | 19-265 (268) | Show / Hide |
Range on Protein: 661-900 Range on HMM: 19-265/268 Sequence Identity: 37% (93 aa) AITFAKLPQNLDKNRYKDVLPYDTTRVLLQ-GNEDYINASYVNMEipaaNLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP . ||||.| ..|||.|| ||| .|. |. .. |||||| |..| .. .|| ||||||||. |||.||.|. ..|| . |....||.|||| etreaklpenrglnryrdvspydhsrikleradvdyinaslvele----eakrrYiLtqGPLphtadHFWqmvWeqnskavimLnkvvEknqikCaqywp DPPD----VMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVR---SLRVDSEPVLVHCSAGIGRTGVL . .... .... ||. . .. | . ... .| | ....| .| ||| |||. . ||.|. || || | |. .||||||||.| |. qeeeeaellleetklkvkliseerksyflvrlleLedletqetreilhfhyttwpdfgvpespaafLkfLfkvresgsLssdvgpavihCsagigrsgtl VTMETAMCLTERNLPIYPLDIVR---KMRDQRAMMVQTSSQYKFVCEAILR ..| . . |.. . .|| . ..| .| ..|| | .| ||| slvdtclveiektgdlnavdikkvLlelRkyRvGLiqtpdqLrFsyiaile |
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| Phosphatase | PTPN3.AA | Subfamily.N20.PD | 665-901 | 39 | 1.3e-57 | 186.9 | In-house | 21-255 (257) | Show / Hide |
Range on Protein: 665-901 Range on HMM: 21-255/257 Sequence Identity: 39% (94 aa) AKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPP-D . | | .||||.|.||||.||| | ..|||||||. . . |||||||| | .|||.| ... .| |.| | | ||..||| gnqpsnreknryrdilpydstrvplgkskdyinasyiriv--ncgeeyfyiatqgpllstiddfwqmvlennsnviamitreieggiikcyhywpislkk VMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVdSEPVLVHCSAGIGRTGVLVTMETAMCLTE .. |.. . . .. | . | . || |.| .||. ||||| | . |.... | | .. . |..||||||||||||.. .. .| . plelkhfrvflenyqilqyfiirmfqvvekstgtshsvkqlqftkwpdhgtpasadsfikyiryarkshl-tgpmvvhcsagigrtgvflcvdvvfcaiv RNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV | . .||| .||.||. |||| ||.|. . .| | kncsfnimdivaqmreqrsgmvqtkeqyhfcydivlev |
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| Phosphatase | PTPN3.AA | Subfamily.R_Ecdysozoa.PD | 649-900 | 31 | 1.9e-55 | 179.4 | In-house | 5-266 (269) | Show / Hide |
Range on Protein: 649-900 Range on HMM: 5-266/269 Sequence Identity: 31% (83 aa) QFEQLYRK-KPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQG-----NEDYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVM .|.| .. . . .... |. ||||.|. ..| ||| |. . ||||||... . . .|.|| |.|. |||.....|.. |||||. | eyekLearleiskstkvsekkenalknryedikafDktrvkLkkingkedsdyinasfik----gykekkkfiaaqdPveatigDfWrmiaeqevtlivm LTTLTERGRTkCHQYWPDPpDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQ---TGEEHTVTHLQYVAWP-DHGVPDDSSDFLEFVNYVRSLRVDS--- || | |..|||. | ...| ... ||. . |. ||. |.... ... |. .| .|. | ||. . |.... ||.| . lsnlteknrk-cakyWpie-devqygdilvklvseekhsdyiireldvskkkeesvedsrkvvqysytgWksDskvPevargllklieqvrelyklnkls ---EPVLVHCSAGIGRTGVLVTMETAM--CLTERNLPIYplDIVRKMRDQRAMMVQTSSQYKFVCEAILR |..|||||| ||.|..|... . . .| .. |. ..|.|.| ||...|| ||.|. |.. gsrsPivvhCsaGvgrsgifvaldlllqqlkaedkvdif--etvkkLrsqrnllvqsleqyvflyralad |
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| Phosphatase | PTPN3.AA | Subfamily.N23.PD | 683-900 | 32 | 4.5e-55 | 178.6 | In-house | 115-347 (350) | Show / Hide |
Range on Protein: 683-900 Range on HMM: 115-347/350 Sequence Identity: 32% (76 aa) DTTRVLLQ------GNEDYINASYVNMEIPaanLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPD-VMNHGGFHIQCQ | .|| || ..|||||.|. | ..||||||.. | | ||..||.|. |.|||||. .|....||.|||| . ...|... ..| dpnrvklqqstqpgqqddyinatylkeltp---msPpfiatqgPiastlaDFWlmvweqqssviVmltkevegnklkcdqYwPidegetnlfgdlrvslk SEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR-----VD-----SEPVLVHCSAGIGRTGVLVTMETAMCLTERN . . .. | . .. ... ..|.||.. .|...|||. .|.|.|.. |.. .. .|...|||||.||||.. . .|. .. . slrssegwiervlhlqhndvstvrlvchlhtttWseiGvPksPedllaflgevetayaqqrktetegeggkPiilhCsaGvgRtgtfcvvysaireltag LPIYP-LDIVRKMRDQRAMMVQTSSQYKFVCEAILR .| ...||..| || |||.. ..|.. ||.|. ngiiniprvvrrlrqqRkymvqkkvilkklyeavle |
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| Phosphatase | PTPN3.AA | Subfamily.RN.PD | 662-898 | 39 | 5.9e-55 | 177.8 | In-house | 19-259 (264) | Show / Hide |
Range on Protein: 662-898 Range on HMM: 19-259/264 Sequence Identity: 39% (97 aa) ITFAKLPQNLDKNRYKDVLPYDTTRVLLQG-----NEDYINASYVNMEIPAAnlvNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQ . || ..|..|||.|.||||| .|| |. ..|||||| . . | | ||||||||..| |.|||.||.| .||.||.|.| |..|..|| kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdpra---payiatqgplsstiadfwqmvweqGvvvivnltrleeegvkqckr YWPDPPDVMnHGGFHIQCQSEDCTI-AYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYV-RSLRVDSEPVLVHCSAGIGRTGVLVT || . .. . .. || |. | . . | || | ||| . ...||..||| . .||| | .| | | |..||||.| ||||| . .. ywpdeGsev-yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyil MEtaMCLTERNLPIYPLDI---VRKMRDQRAMMVQTSSQYKFVCEAI . |. . . .|| . ..||||. .|.| .|..|. |. id--lvlerllkGvkeidiaatlehlrdqrpglvktkdqfefaltav |
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| Phosphatase | PTPN3.AA | Subfamily.N_Nematode_1.PD | 652-900 | 32 | 2.3e-52 | 169.4 | In-house | 8-262 (265) | Show / Hide |
Range on Protein: 652-900 Range on HMM: 8-262/265 Sequence Identity: 32% (84 aa) QLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL---QGNEDYINASYVNMEIPAanlvNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTE .| . .. .. | |. |||||||| | .|| | ||| | || . . . ...| .|.|| .|.|.|| .|.|. |||| | |.| alkkfndeekvkafkeaqeadknrykdvgcldknrvklaeeplpsdyihanyvgtptnp----krficaqaPldktiadfwymvlqekveaivmlcklie RGRTKCHQYWPDP---PDVMNHGGFHIQC------QSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLefvNYVRSLRVDSEPVL ..||..|.| .....| .| . . . . . .| . .....|||.|.|||.||| | . . . |.. .|..|||| kgkkkcaeyfpakegeklefkekgqkitvenslgvkkleedeevikvtvlevegaGektrkvthyqWtdWPdrGvPpadlaal---elleavrgskgPiv VHCSAGIGRTGVLVTMETAMCLTERNLPIYPL-DIVRKMRDQRAMMVQTSSQYKFVCEAILR ||||||| .|..| . . | . ..|.|.|.||.. .|| || || .| vhCsaGiGrtGtivaieyildkllegkqiedmeklvkkireqrnysiqtdaqylfvhrvlln |
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| Phosphatase | PTPN3.AA | Subfamily.N_Nematode_4.PD | 661-896 | 34 | 1.6e-50 | 163.4 | In-house | 17-257 (264) | Show / Hide |
Range on Protein: 661-896 Range on HMM: 17-257/264 Sequence Identity: 34% (85 aa) AITFAKLPQNLDKNRYKDVLPYDTTRVLLQGN---EDYINASYVNMEipaanLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQY ..| .| |||||.|.| | |||.|. . .||| ||.. | .||.|||||..| . || .|. .|.. .||| .| | | || .| nvtasaseknsdknryadilcidetrvvlknrdpdndyihaswmrmP-----dkfryistqGPlketlsdfwhmvytekiavvvmlcdlieegvekcary WPDPPDV-MNHGGFHIQCQSEDCT-IA-YVSREMLVTNTQ-----TGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSlRVDSEPVLVHCSAGIGRT .|. . ...| ..|. . || . . . ||||. . |. | |.|. |.|. | |. ... .|. . ..|. ||||||.||| ypeksekvvkfGkyritlvekkeeviadvilnslkvtntekkkdapseplvvkhvqvdwwrdqvaPldaapviklykavkk-kkkekPivvhcsaGvGrt GVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCE || .. | | | |||||..| | ||. |. |. atlvGidyatirirenseievldivrelramrlkavqshlqflfllv |
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| Phosphatase | PTPN3.AA | Subfamily.RC.PD | 649-902 | 27 | 1.4e-45 | 147.2 | In-house | 5-287 (288) | Show / Hide |
Range on Protein: 649-902 Range on HMM: 5-287/288 Sequence Identity: 27% (80 aa) QFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----------------------Q--GNEDYINASYVNmeipAANLVNKYIATQGPLPHT .|..| . . .| |. ..| .|||| |||||| || | . .|||||... . .||||.|||| | efqrlpsvrskrtikiarkeenksknrysdvlpydynrvelkhelemskesehdsdessdddidseegskyinasfid----sykkpekyiaaqGplket CAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWpdPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEF .||......| .||||| | | | || .|| .| .. . .| . |. | . . | . . .||..|| .|.....|.. .|.. vddfwrmiferkvkvivmltelkeGdrekcaeyw--eeGkrayGdvevdlkdtdkssdyilrklelvnkkrkdsrevtqiqytswsveqlpeepkellkl VNYVRS-----------LRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY .. |. . | |.||||..| .|||. ..... . | . . ..|.|.| .|..||.. ||...... .| iqvvkqklpqkrsseafknfkstpllvhcrdGsqrtGifiallallesleaeekvdvfqvvkklrkarplmvsveeqyillydvlvety |
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| Phosphatase | PTPN3.AA | Subfamily.R_Nematode_2.PD | 670-895 | 33 | 2.2e-45 | 146.4 | In-house | 29-253 (261) | Show / Hide |
Range on Protein: 670-895 Range on HMM: 29-253/261 Sequence Identity: 33% (75 aa) NLDKNRYKDVLPYDTTRV--LLQGNEDYINASYVNMeipaANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD-PPDVMN . ||.||.|| ..|.| . .|. | | .|. |. ...||||||| |. .|| .| .| ||||. |. ..||..|.| . . .. pkdkhRypdvPCkpetavevivdgkrvpihanwvpt----agnpkrfiatqgPlentsedfWamviqekvekivmlcqkvekekekceeYfpletsqkld HGGFHIQCQSEDCTIA-YVSREMLVTNTQTG--EEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSlrvDSEPVLVHCSAGIGRTGVLVTMETAMCLTE | |.|. .|.. . ... | . .|| . .||||.|| |||.|||. . | .. |.. .|..||||||||||. ....| | . lgrfsiktvsaekilkdeiekrtlkvedstgkfatrtvthyqyeeWpdrgvPkshaelfeLlelvkk---sekPivvhCsaGiGRtmafigteylareve RNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVC | . ....|..| . .||.||. .. adptieltealkelrehRwkgiqtesqlywlt |
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| Phosphatase | PTPN3.AA | Subfamily.R_Nematode_3.PD | 660-900 | 27 | 7.7e-45 | 144.8 | In-house | 16-264 (267) | Show / Hide |
Range on Protein: 660-900 Range on HMM: 16-264/267 Sequence Identity: 27% (70 aa) LAITFAklpQNLDKNRYKDVLPYDTTRVLLQG-----NEDYINASYVNMeiPAAnlvNKYIATQGPL--------PHTCAQFWQVVWDQKLSLIVMLTTL |... ......|...|. . .|||.|.| ..|.|.|..|.. | .| | ||.|. |. .||... ..| .||| . natsls---kkvsedrrvevpllektrvvLkgygkrfkddfihAnvvec--png---lklIltqsPqkkdkekkkkstieKfwwmieqekveqvvmlcdf TE---RGRTKCHQYWPDPPD-VMNHGGFHIQC--QSEDCTIAYVSREMLVtNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRvdsEPVLV | .. || .|.|. | ... .|. ..| ... . |.. | . . ..|.|||||.| .|.....|... .|| ...|.. . ||.|| veedgeeeekcseYypekvdgelkfegvsvkctdikkelsedvekrtlvv-tfekkkeftvthllykgWkelnapeepkealelikfveksk---tpvvV HCSAGIGRTGVLVTMETAMCLTERNL-PIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR ||.||.|...|. .| .. | .. . |... ..| |||. .|| ...|| ||. HCsdGisRsatlaaielgyqliikskgkldllslikelrkqRagaiqtelelafvilgilk |
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| Phosphatase | PTPN3.AA | PTPc_motif | 800-900 | 39 | 2.2e-43 | 151.34 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 800-900 Range on HMM: 1-92/92 Sequence Identity: 39% (42 aa) TVTHLQYVAWPDH-----GVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFV ||.|..| .|||| |||. ...|||...||. |..||||||.||||........|.. . ...|..||.||..|||| ||.|. TVHHYHYTNWPDHVEKDSGVPE--DSILEFIRHVRK------PIVVHCSAGCGRTGTFCAIDMMMQQ------VDIFQTVKEMRKQRPGMVQTEEQYIFC CEAILR ...|| YRCILE |
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| Phosphatase | PTPN3.AA | Subfamily.N_Nematode_6.PD | 669-899 | 30 | 1.6e-42 | 137.2 | In-house | 23-249 (253) | Show / Hide |
Range on Protein: 669-899 Range on HMM: 23-249/253 Sequence Identity: 30% (71 aa) QNLDKNRYKDVLPYDTTRVLLQGNED-YINASYVNMEIPaanlVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDP-PDVMN .. |.|||... .|..|. |...|| || |..|.. ...| ||.|| |. .||... . |||| | |.|.|. .| .| | .. kfkdrnrytniqCcdagrlkladdedfyihanlvkistk----prrlictqaplegtieefwkmilssgveyivmlcelvekgkeksaeylsdkvGdark HGGFHIQCQSEDCTI-AYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSlrvDSEPVLVHCSAGIGRTGVLVTMETAMCLTERN . . . . . | ..| ... ...|| | |... .||||||||. | ... |..| |..||||||.|||| |. ..... . itklctvikigrkdidkilvrslkrivkagdeevivkhihWanWPdhGvPdsflsalrllsvvkk---dkkPivvhCsaGvGrtGtlaliliilealrlp LPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL |.. |.|..|. ||| || .. .| dfqgvkdllvklreerfravqtevqylyalrcvl |
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| Phosphatase | PTPN3.AA | Subfamily.N_Nematode_5.PD | 650-899 | 28 | 2.6e-42 | 136.3 | In-house | 6-254 (258) | Show / Hide |
Range on Protein: 650-899 Range on HMM: 6-254/258 Sequence Identity: 28% (73 aa) FEQLYRKKPGLAiTFAKLPQNLDKNRYKDVLPYDTTRVLLQ-GNEDYINASYVNMEipaaNLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTE ||.| || |. . .||.|||.||| .|.||| |. ....|||||..... .| .|.| || |||.| ..||..|..| ..|.|.. | feklaslkpnke-tckafeknlkknrskdvkilDetrVkltdeddsYinaskikld----dlekkliltQlPlpdteedFWrmvyqekitsvvllvedee RGRTKChQYWP-DPPDVMNHGGFHIQCQSEDCTIAY-VSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLE-FVNYVRSLR-VDSEPVLVHCSA .|.. ...| | .|.|.. |... . . | . .|.. ... .. |... |||.... .. .. | | ....||.|....| lketav-sffpletgdylnlgkmfinnrkvevkedekkeytvevlpegcsesvfakvyhlttWkkkkvPdkvkkvikraiekvlskkqgknapvvvvsdl GIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL .||.| ......|.. ... . .|..|.|.||. .|....|| .| .|.| GlgRagtflllsvaieqlnngkepnideilkkirsqRpgavesliqyasvyaavl |
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| Phosphatase | PTPN3.AA | Subfamily.N_Nematode_egg.PD | 649-901 | 28 | 5.3e-33 | 106.0 | In-house | 5-255 (257) | Show / Hide |
Range on Protein: 649-901 Range on HMM: 5-255/257 Sequence Identity: 28% (76 aa) QFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGN-----EDYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVML .||.| | ..| | ..|.| | | | ...|| |. . .|.| | .|. |.|..| .| || |.||..|. .| |||||. rfeilersvdeislttaasdnylekarskrvhckessrvklelrrGqylddfihanrvk----Gkpllnefilaqaplkntvedfwrmvfqekvqyivml TTLTERgrTKCHQYWPDPP-D--VMNHGGFHIQCQSEDCT---IAYVSREMLVTNTqtGEEHTVTHLQYvawpDHgvpDDSSDFLEFVNYVRSLRVDSEP | .|. ||| . . |. |...|.. | . |.. || || .| |. | . .|| .. .| || |.||.| tsakes--erceyywpkaeseslvtvpGslrienlkvdskadplfrvtklklvGgd--deelflehwqg----dv---nylsdvysplrvlrklrnlskp VLVHCSAGIGRTGVLVTMETAMCLTERNlPIYPLDIVRK---MRDQRAMMVQTSSQYKFVCEAILRV .. |. ....||..|.|.. | ||. . | .| .| . |.. .| || .|. vvvqdilGvskaatlvaieiallsllrG-pitkslvlravvflrlrrrlsvesvllylfvyrlvlff |
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| Phosphatase | PTPN3.AA | Subfamily.N_Fungi_PTP1.PD | 671-760 | 36 | 5e-27 | 86.3 | In-house | 46-150 (343) | Show / Hide |
Range on Protein: 671-760 Range on HMM: 46-150/343 Sequence Identity: 36% (38 aa) LDKNRYKDVLPYDTTRVLLQ-------------GNEDYINASYVNMEIPAANLVN--KYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCH |||||..|||. .|| |. .|||||.|.... .. . ||||||.||| | .|..|. | .|..||.. | .. ||..| faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy QYWPD |.. rYWqe |
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| Phosphatase | PTPN3.AA | Subfamily.N_Nematode_eak.PD | 653-829 | 25 | 5.2e-19 | 60.1 | In-house | 9-183 (281) | Show / Hide |
Range on Protein: 653-829 Range on HMM: 9-183/281 Sequence Identity: 25% (45 aa) LYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQG----NEDYINASYvnMEIPaaNLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTE | .... |.|. .. .....|| ...|.| | | .. ||||| .| . .. .||| | . . |||.| .|| ||.| | lddyqrllsirvtarleavnrnrvvkivpqdrylvrltssqlnrdGyinasl--aefs--evGrkyiltGiasedkvfafwqmvleqkspaivqlledve RGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTnTQTGEEHTVTHLQYVAWPDHGVPDdSSDFLEFVNYVR . | .|.|| .|...| ....... . . .|. .. | | | | .. | ..| ||| . . .. ekleksdkyfpdktevlkyGildverkeyavkrniletrllil-rkGnethrvlhykvfGwtettlpk-yedflalrkvmk |
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| Phosphatase | PTPN3.AA | Subfamily.N_Fungi_PTP1.PD | 788-900 | 29 | 2.8e-14 | 44.4 | In-house | 202-340 (343) | Show / Hide |
Range on Protein: 788-900 Range on HMM: 202-340/343 Sequence Identity: 29% (38 aa) MLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVN-----------YVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMC-------LTERNLPIY . ... .| ..| .||. |.| .. . ..|. .. . |.|.|||||||.||||.|||.. .||.. . ltpvtaavsepyevyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkld ----P----LDIVRKMRDQRAMMVQTSSQYKFVCEAILR || ..| || |||. |. |. ||.| vaaktrDlisiivnelrkqrismvqnldqfifiYeallf |
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| Phosphatase | PTPN3.AA | Family.DSP.PD | 781-891 | 22 | 6e-13 | 40.4 | In-house | 148-236 (387) | Show / Hide |
Range on Protein: 781-891
Range on HMM: 148-236/387
Sequence Identity: 22% (21 aa)
IayvsremlvtntqtgeEHTVTHLQYvAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTmetAMCLTERNLPIYplDIVRKMRDQ
|. ...|.. ...||..|. .. | ...... . ..... ||||| ||.||.|.|. | .. ..| . ...|..| ... ....
k----------------elgikylri-pidDhnapplenlfekaidfieegndskgvVlVHCkaGkgRsgtlii---aYlmksegltle--ealdwvrsk
RAMMVQTSSQY
Rpgvitpnqgf
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| Phosphatase | PTPN3.AA | Subfamily.PTPDC1.PD | 801-896 | 26 | 2.8e-10 | 31.5 | In-house | 135-222 (229) | Show / Hide |
Range on Protein: 801-896 Range on HMM: 135-222/229 Sequence Identity: 26% (25 aa) VTHLQYvAWPDHGVPDdSSDFLEFVNYVRSlRVDSEPVLVHCSAGIGRTGVLVTmeTAMCLTERnlpIYPLDIVRKMRDQRAMMVQTSSQYKFVCE ... .. ...|.||. |. | | . . . ||| || ||||||.. . . ..| . . . ....|..|. .|| .|..| | iyfynf-glkDygvas-leriLdivkvvdf-aleegkiavHCHAGlGRtGvlia--cylvyakr---ltaeeaiklvrskrpksiqtreqvelvee |
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| Phosphatase | PTPN3.AA | Subfamily.PTPMT1.PD | 789-892 | 22 | 7.4e-07 | 20.6 | In-house | 41-138 (146) | Show / Hide |
Range on Protein: 789-892 Range on HMM: 41-138/146 Sequence Identity: 22% (23 aa) LVTNTQTGEEHTVTHLQYVAWpDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTmetamCLTERNLPIYPLDIVRKMRDQRAMMVQTS |. .|. ... |..||. . |.. . | |... . . . . | ||| || .| . ||. | .. . | . |. ....| . | lansteewkklGveqlqlatv-DfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlva-----cylmkkkklspeeavkflkkkRpqirlks SQYK .|.. kqwr |
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| Phosphatase | PTPN3.AA | Subfamily.DSP15.PD | 818-865 | 37 | 7.9e-07 | 20.6 | In-house | 61-107 (138) | Show / Hide |
Range on Protein: 818-865 Range on HMM: 61-107/138 Sequence Identity: 37% (18 aa) SSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTmETAMCLTERN |. | | .... . |.. . ||||| ||| |. ||. | .|| . skffkesidfihkcrleggnvlvhclaGisrsvtlvv-ayimtvtels |
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| Phosphatase | PTPN3.AA | Subfamily.DSP23.PD | 806-894 | 28 | 8.6e-07 | 20.6 | In-house | 38-120 (128) | Show / Hide |
Range on Protein: 806-894 Range on HMM: 38-120/128 Sequence Identity: 28% (25 aa) YVAWPDHGVPdDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTmetAMCLTERNLPiyPLDIVRKMRDQRAMMVQTSSQYKFV . ||. | ..|. | |.| ||| |.|||| |.. . |..| | . .| .| ..| | | | ridipdfcPP-aleqvarlvriveeaekkeeavgvhcalGlGrtGtlla---cylvkeegla--addaiaevrkrrkGsietveqekav |
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