Gene PTPN4
PTPN4
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of PTPN4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| FERM | PTPN4.AA | B41 | 25-222 | 33 | 3e-85 | 290.42 | SMART | 1-232 (232) | Show / Hide |
Range on Protein: 25-222 Range on HMM: 1-232/232 Sequence Identity: 33% (79 aa) QHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDL--TEQDYFGLQLADDSTDNPRWLDPNKPIRKQLKR---GSPYSLNFRVKFFVSD----PN ......|.....|.|.. |.|... ||.|.| |..|... .|..||||...|. | ..|||..|.|.|| .. . |. | |||||...| || SPKPRFCRVYFMDGTTLEFEVDSSTTGQDLCDHVCRHCGISPREHWYFGLWYEDPHED-RHWLDHWKTIMKQDVKWHKSEPWTLHFRVKFYPPDWHGFPN KLQEEYTRY-QYFLQIKQDILTGRLPCP-SNTAALLASFAVQSELGDYDQS--------ENLSGYLSDYSFIPNQ---------------PQDFEKEIAK .|||..||| ...||...|||.||.||| .....||...||.|.||||.. . ...|.|.. |.|.| .....| |.. QLQEDPTRYNYFYLQCRHDILQGRHPCPHEEECLQLAALQVQIEYGDYDPEETNNKKMTKHVQKYKSYKRFLPKQWIDSIKQSFMHYQMHHKEWRKRIME LHQQHIGLSPAEAEFNYLNTARTLE-LYGVEFH .|..|.|..|.||...||....... .||||.. WHKNHCGMTPEEAKLKYLQICQRWPPMYGVEHF |
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| FERM | PTPN4.AA | FERM_M | 113-222 | 25 | 7.9e-46 | 158.39 | Pfam | 1-171 (171) | Show / Hide |
Range on Protein: 113-222
Range on HMM: 1-171/171
Sequence Identity: 25% (43 aa)
DPNK-LQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQSELG-DYD-QSENLSGY-LSDY-------------------SFIP-----------
|||. .|.| ||.|..||.|.||| ||.||. .|..||. ..|.|.| ||. ... |.| .. . ...|
DPNRDIQDEVTRHQFYLQAKWDILEGRYPCSEEEALMLAAYQCQIEFGSDYNPPQKHKSDYMEKEWWEQQEGMEVWLRCDNEQQERYWPAHCRLASKGRT
--------------------------NQPQDFEKEIAKLHQQHIGL-SPAEAEFNYLNTARTLELYGVEFH
.. ..|..|. .|..|.|. ||.||. .|........ |||.|.
MADSSYSEVSIRINPHCYVSPWYCKKMKQKQWEQRILEQHKNHRGMCSPEEAMLQYIQICQRWPMYGVHFF
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| FERM_C | PTPN4.AA | FERM_C | 226-316 | 47 | 3.5e-45 | 161.2 | Pfam | 1-99 (99) | Show / Hide |
Range on Protein: 226-316 Range on HMM: 1-99/99 Sequence Identity: 47% (47 aa) DQSNNE-IMIGVMSGGILIY--KNRVRM---NTFPWLKIVKISFKCKQFFIQLR--KELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPP | .... ...||.. ||..| ... .. ||||| .|.||||| |.|||.|| .. .|..|. ..|.| ||||||.||| |||||.|||| || .. DKKGTDTWWLGVCAKGINVYQVQDNNKITPMNTFPWPEIRKISFKRKKFFIKLRDDPDEGEKYEHTHTFYMPNYRACKYLWKCCVEHHQFFRLRRPPDT |
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| FERM | PTPN4.AA | FERM_N | 33-111 | 37 | 1.7e-30 | 111.94 | Pfam | 1-93 (93) | Show / Hide |
Range on Protein: 33-111 Range on HMM: 1-93/93 Sequence Identity: 37% (35 aa) ILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQL--ADDST--DNP-RWLDPNKPIRKQLKR---------GSPYSLNFRVKFFV ..||| |. ....|.. ||.|.| |..||...| .||||| .|. ... .||||.|.|.||.|. . |. | |||||.. VHLLDDTQLECTCDKKTTGQELFDQVCQHLNIRECWYFGLQFCKQNDKKEGNQHMHWLDPDKKICKQMKDGWKHKIKKKCPPCTLFFRVKFYP |
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| FA | PTPN4.AA | FA | 322-368 | 41 | 1e-16 | 62.03 | Pfam | 1-48 (48) | Show / Hide |
Range on Protein: 322-368 Range on HMM: 1-48/48 Sequence Identity: 41% (20 aa) AHYF-TLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKLM ...| ..||||||.|||. |...| .|. |.. | ||||| .. KRFFCSWGSKFRYSGRTQYQTIEYSREHQRKPPQFHRSPSKRYPSRRS |
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| PDZ | PTPN4.AA | PDZ | 517-602 | 37 | 3.8e-26 | 92.14 | Pfam | 1-86 (86) | Show / Hide |
Range on Protein: 517-602 Range on HMM: 1-86/86 Sequence Identity: 37% (33 aa) LIRMKPD-ENGRFGFNVKGGYDQK--MPVIVSRVAPGTPADLCVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCERHSGELMLLVR ....... ..|..||..||| ||. .....|.| || .|. . .|..||||.. |||.||. .|||..|..|| |.. ||. |... QVTLEKQDKRGGLGFSIKGGNDQRHDQGIYISEVMPGSGAAERGGRIHEGDQIISINGQDIRNMTHDRAVQAIKGSKG---GEVHLTIQ |
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| Phosphatase | PTPN4.AA | PTPc | 654-913 | 35 | 1.1e-121 | 411.54 | SMART | 1-308 (308) | Show / Hide |
Range on Protein: 654-913 Range on HMM: 1-308/308 Sequence Identity: 35% (114 aa) TVLTQFDQLYRKKPGM---------TMSCAKLPQNI--SKNRYR-DISPYDATRVILKGNE---------DYINANYINMEIPSSSIINQYIACQGPLPH . ..|. |.| .|.. ...||..| |. .||||. || .|| |||.|| .. ||||||||... ..||..|||||| GFWEEFERLQRMTPWDLMSNYDPCCSCTCACWPENREMDKNRYKCDIPCYDHTRVKLKPPPGESHCYEGSDYINANYIDGY----WRPKRYICTQGPLPH TCTDFWQMTWEQGSSMVVMLTTQVER--------GRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNT-AYIFRKMTLFNQEK--------NESRPLTQIQY |. |||.| |.|... .|||.. .|. ||.|||||||. . || ..||| ||| |. |.... |.. .|.| .|...| TIEDFWRMVWQQKCHIIVMLCNCMEKCTENRDQNGREKCHQYWPDE--PMTYGHITVTCKSEEKCPDDYTMRTFEVTNTGCNCKYSMACSETRTVTHYHY IAWPDHGVPDDSSDFLDFVCHVRNKRAGKEE-------------------PVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQ .|||||||.....||||. ||.... ... |.|||||||.||||...........||. | ...||..||.||..|.| TNWPDHGVPESPDSFLDFIRQVRHWQSHSPNMYMNMVSSNSKYHHTCPTGPIVVHCSAGCGRTGTFCAIDIMCQQIEN---VDIFQIVKMMRNQRPGMVQ TPSQYRFVCEAILKVYE |. ||.|....||.... TEEQYIFCYRCILEYIK |
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| PDZ | PTPN4.AA | PDZ | 526-605 | 25 | 5.1e-16 | 60.45 | SMART | 1-80 (80) | Show / Hide |
Range on Protein: 526-605 Range on HMM: 1-80/80 Sequence Identity: 25% (22 aa) GRFGFNVKGGYDQKMPVIVSRVAPGTPADLCV----PRLNEGDQVVLING-RDIAEHTHDQVVLFIKASCERH-SGELMLLVRPNA | .||...| ....|.| ||.||. . ..| .||... .|| .. ||.|.|...|...... .. |.|... GGLGFSIVG------GIFISSVVPGGPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG |
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| Phosphatase | PTPN4.AA | Subfamily.N3.PD | 655-913 | 66 | 1.6e-143 | 468.0 | In-house | 2-261 (261) | Show / Hide |
Range on Protein: 655-913 Range on HMM: 2-261/261 Sequence Identity: 66% (173 aa) VLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNE-DYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLT ||.||..|||||||...|.|..|.|..|||||||.|||||||.|| .| |||||||.||||||....|.|||.||||..|..|||||.||| |...|||| vlaqfeelyrkkpglaisaarkpenlaknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGplaktakdfWqmvweqkstlivmlt TQVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCS |.||||||||||||||.. . ..|...|.|..|. ...|..|...| ..|..|.| ..|.||.|||||||||||.|||.||..||..|.||||||||||| tlverGrvkChqyWPetedelefgefsvrcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCs AGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYE ||||||||||..|||..|||...|||||||||||||||||..||.|||.||||||||.|| aGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtvsqykfvCeailkaye |
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| Phosphatase | PTPN4.AA | Y_phosphatase | 679-910 | 42 | 2.3e-112 | 384.42 | Pfam | 1-243 (243) | Show / Hide |
Range on Protein: 679-910 Range on HMM: 1-243/243 Sequence Identity: 42% (105 aa) NISKNRYRDISPYDATRVILK-----GNEDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGR-VK-CHQYWPE-- | .||||.|| .|| |||.|. .. ||||||||.. .. ..||..|||.|||. |||.| |.|.....|||.. .|.|| .| ||||||. NKEKNRYKDIPCYDHTRVKLQPIPGDEDSDYINANYIDG---PYWNPKAYICTQGPMPHTIEDFWRMVWQQKCTCIVMLCNCMEMGRDEKTCHQYWPDNK PTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQE--KNESRPLTQIQYIAWPDHGVPDD-SSDFLDFVCHVRNKRA-GKEE--PVVVHCSAGIGRTGVLI .. .|| .|||| ||| .. |. |.... | . |.|.| .|...|..|||||||.. . ..|||. ||... . |.|||||||.||||... EGQPMTYGDFQVTCVSEEHCPDYTVRTFEVTN-GDQKQETRTVTHYHYTNWPDHGVPESQPKSMLDFIRQVRKWQPNPDHGCPPIVVHCSAGCGRTGTFC TMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK .........|... | ..||..|| ||..|.||..||.|....|| AIDIMCQQMEHEGTVDIFQIVKHMRNQRPGMVQTEEQYIFCYQCILE |
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| Phosphatase | PTPN4.AA | Subfamily.N13.PD | 658-911 | 41 | 9.3e-83 | 269.1 | In-house | 5-257 (259) | Show / Hide |
Range on Protein: 658-911 Range on HMM: 5-257/259 Sequence Identity: 41% (106 aa) QFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINMEIpsSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVE .|..| || | . .| .| .|||||.. |||.|||.|... ||||..|.... .|||||||||.|..||||| ||| .....|.|...| efkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdeggyinaslikvpv--gedeyeyiacqGPlPetvkdfwqmvweqkaeviamvtleke RGRVKCHQYWPEPTGSSS--YGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAgKEEPVVVHCSAG .|.||||.|||| .... .. ..|. . .. |.... ..| .||| ........||||||| . ... ||..||. ... |.||||||||| kgkvkchrywPerknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaelvqfvaevrllqt-dagPivvhcsaG IGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV |.|||||..... ||| .... .|||..|.|| ..|| || || .|||.| iGrsGvlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev |
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| Phosphatase | PTPN4.AA | Subfamily.N_Choan_1.PD | 657-911 | 38 | 2.4e-81 | 264.4 | In-house | 4-260 (262) | Show / Hide |
Range on Protein: 657-911 Range on HMM: 4-260/262 Sequence Identity: 38% (99 aa) TQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINME-IPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQ .....|. . | . .| ..|. ||||..|. |||||| .. ||. |..||| . .|. . ..|||.|||.|.....|||| ||| |..||.| . eeyeklaeigvdntataskadenvlknrysnivayDatrvkvtpneenkntDyinanfvpgykgekeyiatqgPvPaslvsfWqmvweqkvsaivmvtre VERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLfNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHV-RNKRAGKEEPVVVHCSA .| |..|||.|||... . ..| ..|. .||| .. || ||..| ..|..|.| ..|..|.||||||||......|.| | . .. .. |.|.|||| ieagklkChryWPdenselklgdvtvkslseeekktyierkfkl-eresgetreveqlaytaWPdhGvPattkellefrkavlkatkkktkaplvihCsa GIGRTGVLITMETAMCLIECNQPV-YPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV |.||||. |...... .| .... . ..|. .| .| .|.|| ||.|| |.|.. GvGrtGtyialDrlvkaveekaealdvkavvaelrkernlmvqtlvqyefvykavlda |
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| Phosphatase | PTPN4.AA | Subfamily.RB.PD | 658-912 | 38 | 1.7e-79 | 258.3 | In-house | 5-260 (261) | Show / Hide |
Range on Protein: 658-912 Range on HMM: 5-260/261 Sequence Identity: 38% (98 aa) QFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYIN-MEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQV ....| . . .... |....| |||.. | |||..|| |. ..| ...||| . || . ..|||.|||||.| |||.|.||. ||..|||| | eyeelkkvgkdqavkaaeeavnraknrftnilpydhsrvkLaalkdesdtdyinanyipgynspreyiatqGPlpetvddfWrmvwekkssiivmltqlv ERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNqeKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGK--EEPVVVHCSA |.|..||..|||. . . || .|| .|. .. .. |.... . ..|.| ..| ....|||||||.... |||| .||.. |..|.|||||||. EkgkekceeYWPadeepvlyGdikvtllaekeldewvirefkiek--gkekrkvrqyhftsWpdhgvPektktlldfvrtvreaiekkaskkPivvHCsa GIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVY ||||. |.... . || |. | . .| .| .|....|| .|| |. |..|.. GvGRtGtfialdrllqaieendyvdvfgvvaelReeRnllvqtekqyifiheclldll |
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| Phosphatase | PTPN4.AA | Subfamily.R_Anemone_2.PD | 657-910 | 39 | 8.7e-77 | 249.6 | In-house | 4-259 (262) | Show / Hide |
Range on Protein: 657-910 Range on HMM: 4-259/262 Sequence Identity: 39% (101 aa) TQFDQLYRKKPG-MTMSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINME-IPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTT .....| |.. .|.. | | | |||| .| .|| ||| |. |. ...||| . |. ..|||.|.|||.|..|||.| |||.|...|||| eeyerlsrseetsvtlksalepvnkaknryanilaydktrvklqmlegeegsdyinanyidGyrrkkayiatqaPlpetiedfWrmvWeqnsavivmltq QVERGRVKCHQYWPEpTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKR-AGKEEPVVVHCS ..|||..|.|.|||. .|| ||| .|. ..| . |. |.... ..|..|.| . | .| .|||.|||......||.| .|.. ...|.||||| eeergkakvhryWPs-kgsrsygklvvelkeevelsdyvlrsfkvkrteeeeerqvrqfhytsWpdegvpesgaslldlvrqvekaqqesgagpivvhcs AGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK ||.||||| |.... . |. .. | ...|...|.|| .|.|| .|| |. ...|. aGvGrtGvfiavdillerikaealvdvfqtvkqlreqrnlmvqtkdqyefiydvlle |
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| Phosphatase | PTPN4.AA | Subfamily.N6.PD | 655-910 | 37 | 2.4e-74 | 241.6 | In-house | 14-292 (295) | Show / Hide |
Range on Protein: 655-910 Range on HMM: 14-292/295 Sequence Identity: 37% (103 aa) VLTQFDQLYRKKPGMTM--SCAKLPQNISKNRYRDISPYDATRVILKGN------EDYINANYI--------NMEIPSSS-IINQYIACQGPLPHTCTDF . ..|..| ... .. . .. ..| .||||..| |.| |||||| .|||||||| . | . |. ..||| ||.|..| .|| fweefeelqkqeseklysrkegekienkeknryknilPfDhtrvilkdgepsvpgsdYiNanyirlpkaskssgenveseehqkryiatqgcLkdtvsdF WQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQ-EKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCH |.| |.. | ..||.| .||||. || .|||. . ....| ..||. ||. ...|..|.... .. ...|.| . | .. |||||||||.. .|.|. .| WrmvwqensrvivmttkevergknkCarYWPdeetkketGvitvtsisEkstadYtlRefsvshkdkdkeareifqyhfkaWPdhgvpkdpgvvlnfled VRNKR--AGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIV---RTMRDQRAMMIQTPSQYRFVCEAILK ..|. |. |.|||||||||||| .| ... . .|| .. ...|| ...| ||. ..|| ||.|| |. . vnkkqeelekagpivvhcsaGiGrtGtfividivlkiieqsgldvdidisksikdvrsqrsglvqteaqykfvykavqf |
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| Phosphatase | PTPN4.AA | Subfamily.N12.PD | 657-911 | 36 | 6.9e-74 | 239.7 | In-house | 10-268 (270) | Show / Hide |
Range on Protein: 657-911 Range on HMM: 10-268/270 Sequence Identity: 36% (96 aa) TQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKG-----NEDYINANYINMeiPSSSiiNQYIACQGPLPHTCTDFWQMTWEQGSSMVVM . . |... .. .... ..|. ||||.|| ||| .||.|. ..||||||.|. .... .|||.|||||.| .|||.| ||...|||. kklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdyinanfikg--vegk--leyiaaqgPLpktlddfWrmiweknveivvm LTTQVERGRVKCHQYWPEPTGSSS-YGCYQVTCHSEEGNT-AYIFRKMTLFNQekNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVV .|| |. ||..|||| .... .| ..||...|. . .. | ... .| .||| ..|..| |||||||| .. |....||. . ...|.||||| aCrevelgkkkCeryWpeegeeelefgefevtleeekavdddflirtLkveaq--kesrkvyqfhytaWPDhgvPssaksllelielvrelqesedaPlv VHCSAGIGRTGVLITMETAMCLIECNQP---VYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV ||.||||..|... . |.. .. . |.| ..| ||| ..|| ||..| .|.... vhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael |
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| Phosphatase | PTPN4.AA | Subfamily.R_Sponge_2.PD | 660-910 | 35 | 6.5e-72 | 233.5 | In-house | 6-259 (262) | Show / Hide |
Range on Protein: 660-910 Range on HMM: 6-259/262 Sequence Identity: 35% (90 aa) DQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKG----NEDYINANYINMeipsSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQ .. .|. ...| |||..|..|||...| ||| .|| |. . |||||.... ..||| ||||..| ||| |||. .|..|||| . eksveketefslsiaklkenvgKnRfkeilpydmsRvrLrtdgskdsDYinAsfvdg----ykrrkayiatqgPlketveDfWRmvweykvstivmltnl VERGRVKCHQYWPEP-TGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNE-SRPLTQIQYIAWPDHGVPDDSSDFLDFVCHV-RNKRAGKEEPVVVHC |.|. ||..|||| .. .|| ..|| ..|| . || ||..| .....| .. .|| ...|||.|.||.|.. .|... .| |... ......|.|| eengkekcakYWPekvdeeveygkfkvtlkeeekladyiirklklskekssegeadvtqfhfvaWpehevPkdatsllelikrvlraqkksgnkaitvvC SAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK .|.|||| |.... . .. .. . ....|.| .| ...|. .|| |. .|.|. sdgvgrtGtfialdsvlerlkaeeeidvfevlktlrtkriglvqdaaqYvfihdalle |
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| Phosphatase | PTPN4.AA | Subfamily.N14.PD | 655-910 | 35 | 2.2e-71 | 231.7 | In-house | 2-272 (275) | Show / Hide |
Range on Protein: 655-910
Range on HMM: 2-272/275
Sequence Identity: 35% (98 aa)
VLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKG----NEDYINANYINMEIpsSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVV
| |..... .|. ..|.||||.| .|||..|. ||. .|| |. ...|||| |.. . .. .||..||||..|..||||| |||| ...|
vfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsv--ggkersyivaqgPleltvqdfwqmvweqgvqliv
MLTTQVERGRVKCHQYWPEP---TGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVR---NKRAGK
||| . | |. |...|.|. . .| ..|| . | ...| ....| .| | . .||. |||||||.| ..||.|. .|. .| .
mlteeeedgkeksfkylPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsfLeevqsvrrktnse
-------EEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK
. ||.||||||.|||||||. . . .|.|. . .....| || ...|| .||.|| ....|
vesvkeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLrkqrmllvqtlaqykfvykvlik
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| Phosphatase | PTPN4.AA | Subfamily.R_Anemone_1.PD | 659-911 | 33 | 5.8e-71 | 230.6 | In-house | 6-256 (258) | Show / Hide |
Range on Protein: 659-911 Range on HMM: 6-256/258 Sequence Identity: 33% (87 aa) FDQLYrKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKG-----NEDYINANYINMEIpssSIiNQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLT |..| ... .....|. ..| .|||| || ..| .||.|. . ||||| |.. ...||.|.||..|. |||.| |.. .. .|||| fqrlk-eikeeekevarkaenkkknryadivaldhsRvvLeklsndeesdYinasylrasd---kt-rafiatqapleetvedFWrmvwqekigviVmLt TQVERGRVKCHQYWPEptGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCS . .| |||||||. ....|| ..|. ...| . || |...| .....|.| ..|.... |||.|||. . . |... .|.... ...||||||| nliegekkkchqYwPd--stekygelrvslrkkevfadyiirtlvlskkketeerevvqyhftvWpdkgvPqyatavLglrrkvqksslagarpvvvhCs AGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV ||.||||. . ... . . .. | ..|...| .|. |.|| .|| |. .|.|. aGvgRtGaflvidamleqakkekvvDifnyvkairedrphmvqtkeqyvfihlavlea |
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| Phosphatase | PTPN4.AA | Subfamily.N9.PD | 657-910 | 39 | 6e-68 | 220.6 | In-house | 4-272 (275) | Show / Hide |
Range on Protein: 657-910 Range on HMM: 4-272/275 Sequence Identity: 39% (105 aa) TQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNE-----DYINANYINmeipSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVM .. .. .... |. ..||. |..|||| |. || ||| |. . ||||||... . .|| ||||..|..|||.| |||..|| | keyadirnepveGtflasklranleknrytdvlcydetrvklakldedeasdyinanfvd----GykqkkafiatqGplkktvsdfwrmvweqevlvivm LTTQVERGRVKCHQYWP-EPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAG------- |||||.|| |||| | |...| ..|. . | . .| .|.... | ...||| .| |...|||.|||......||.. .||.|.| ttrvvergrlkcgqywpleeessaefgdlsvsnveveveedykvrvleiknvkteesrkvthfqflswPdyGvPssaaslldvlekvrekqalavkelgd ------KEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK .. |.|||||||||||| .||.. .. .| . | . |...| ||| .|||| || | |.| eskghlsgPPivvhcsaGiGrtGtfitldiclarleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle |
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| Phosphatase | PTPN4.AA | Subfamily.RK.PD | 670-911 | 33 | 6e-65 | 210.4 | In-house | 20-265 (267) | Show / Hide |
Range on Protein: 670-911 Range on HMM: 20-265/267 Sequence Identity: 33% (84 aa) TMSCAKLPQNISKNRYRDISPYDATRVILKGNE----DYINANYInmeiPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQ-VERGRVKCH .. ||...| .|||. || .|| ..|.|. . |||||..| | ...|. ||||..| .|||.. ...... .|||| ||.||||| . dcdiakkdrnreknrsmdilaydrslvflisvdgdssdyinaali----dsykrpaafivtqgPlqetvkdfWrlvydencasivmlteldvevgrvkCl QYWPEPTgSSSYGCYQVTCHSEEGNTAYIFRKMTLFN--QEKNESRPLTQIQYIAWPDH-GVPDDSSDFLDFVCHVRNKRAG-KEEPVVVHCSAGIGRTG |||| | . || .|.. . | .. .. | ... . . ..| | . |.|...||.. .||. .|... .| .... .| ..||||.|| ||.|. kyWPedt-evrygdikvelveaeldadlvvrifrveklargqeeirevrqfqflgWpeyrdvPvskrsllklirrvkksqeeeeeGrivvhClaGaGrsG VLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV |.... . .||... | .|.|.|.... |..| ||.|| ..|| tfiaidivlemieregvvdvfnavktlrnrkvnmveteeqykfvydvilea |
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| Phosphatase | PTPN4.AA | Subfamily.RA.PD | 669-912 | 34 | 4.3e-64 | 207.8 | In-house | 17-265 (266) | Show / Hide |
Range on Protein: 669-912 Range on HMM: 17-265/266 Sequence Identity: 34% (86 aa) MTMSCAKLPQNISKNRYRDISPYDATRVILKGN-----EDYINANYINmeipSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKC .. |....| |||. .| ||| .|||| ||||| .|. ...||.|||. .| |||.| ||| |. .|||| ||.. ||. eklrtankeenkkknrvvqilpydfsrvilsvkeGeeesdyinasfid----GyrekdkfiaaqGpkeetvedfwrmiweqksativmltelkerkeekc HQYWPEpTGSSSYGCYQVTCHSEEGNTAYIFRKMTLF----NQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEE-PVVVHCSAGIGR ||||. |. .|| .|. . |. .| |.. . ......|| ..|. . .||. ||| .. |... .|.... . .|.|||||||.|||| aqywpd-eGlvtyGeirvevkdetvledytvrdflvtqlpdatrekksrlvrqfhftswpevGvpaegkGmlkllkkvkklqqqsanhpivvhcsaGvGr TGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVY .|.... . ..... . ..|...| ||. |.|| || |. ...|. . tGtfivldavlervkaerkldvfeavkrlrlqrpqmvqtleqyefiykvlleyi |
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| Phosphatase | PTPN4.AA | Subfamily.N1.PD | 669-910 | 39 | 1.9e-62 | 202.5 | In-house | 18-265 (268) | Show / Hide |
Range on Protein: 669-910 Range on HMM: 18-265/268 Sequence Identity: 39% (100 aa) MTMSCAKLPQNISKNRYRDISPYDATRVILK-GNEDYINANYINMEipssSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYW . .. ||||.| ..|||||.|||| .|..|. .. |||||. ...| . .|| |||||||.. |||| ||| | |.|| ||....||.||| letreaklpenrglnryrdvspydhsrikleradvdyinaslvele----eakrrYiLtqGPLphtadHFWqmvWeqnskavimLnkvvEknqikCaqyw PEPTGSS--SYG--CYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAG--KEEPVVVHCSAGIGRTGV |. . .. . ..|. ||| . .. |.. | . |..|.| ... .| ||| |||. . ||.|. .||. . . |.|.||||||||.| pqeeeeaellleetklkvkliseerksyflvrlleLedletqetreilhfhyttwpdfgvpespaafLkfLfkvresgsLssdvgpavihCsagigrsgt LITMETAMCLIECNQPVYPLDIVR---TMRDQRAMMIQTPSQYRFVCEAILK | ..| . .|| .. . .|| . .| .| .|||| | || |||. lslvdtclveiektgdlnavdikkvLlelRkyRvGLiqtpdqLrFsyiaile |
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| Phosphatase | PTPN4.AA | Subfamily.N5_RR.PD | 674-910 | 35 | 1.6e-61 | 199.4 | In-house | 18-262 (265) | Show / Hide |
Range on Protein: 674-910 Range on HMM: 18-262/265 Sequence Identity: 35% (87 aa) AKLPQNISKNRYRDISPYDATRVILKG------NEDYINANYINMEipsSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYW ... . .||||..| | . .||.|. . .||||||| . . |.| |||||.| .|||.| ... ....|||| |.| ||..|.|. levfgsqtknryktilPnensrvllesessededssyinanyikGy---deeskayvatqGPlpntiadfWrmiyqeevqvivmltklkeanrqkcavyf PEPTGS---SSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKnESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGK---EEPVVVHCSAGIGRTGV .. || ... .. . | ||..| ..|. .| .. . | .|||| .||| . .||.| .|...| .||||||||||||||. |... | Pdaedyeiserygdveikveeiverndysvrklvlkyler-versvkhywytdWPdhksPddintlldlvleveesreeenaklaPvvvhcsaGiGrtGc LITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK . .. .. | | || .| .| |.|| .||... .|. . fiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl |
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| Phosphatase | PTPN4.AA | Subfamily.N_Choan_2.PD | 672-910 | 37 | 5.5e-60 | 194.2 | In-house | 11-263 (266) | Show / Hide |
Range on Protein: 672-910 Range on HMM: 11-263/266 Sequence Identity: 37% (95 aa) SCAKLPQNISK---NRYRDISPYDATRVILKGN-----EDYINANYINmeiPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKC | ..|. ... |||.|| | ||||.|. ||||||.. .. ..||| .|||| | ..||.| ||. .. .||.| .|.|| || seeaiPeyarnkrlnRyndiLPsPatRvrleeleedsataYinAnyvr---GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkC HQYWPEPTGS---SSYGCYQVTCHSEEGNTAYIFRKMTLFNqeKNESRPLTQIQYIAWPDHGVPDDSS------DFLDFVCHVRNKRA--GKEEPVVVHC .|||. ... ..| .|. ||| .. ||.....| . |.|.| |. .| .||||||| ... |. . .||. | |.||..||||||.||| erYWpaepkekvkladgkikvlalseekeegyiltrlrlek--kgetrrlvHfwyntWpdhgvpreedsslstdqllkmlravrrvrkeldkaePllvHc SAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK |.||....|..|.| .. | .| |.. .| .| ..|.| ||... .|... saGvgRtGtliaiDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyellykavve |
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| Phosphatase | PTPN4.AA | Subfamily.RG.PD | 658-911 | 31 | 5.8e-59 | 191.1 | In-house | 5-262 (264) | Show / Hide |
Range on Protein: 658-911 Range on HMM: 5-262/264 Sequence Identity: 31% (82 aa) QFDQLYR-KKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKG-----NEDYINANYINmeipSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVM ||... . |. .... .| ..| |||. .| ... .|| |.. ..|||||.||. ..||. ||||..|. |||.| ||.....||| qfeeiqklkpkdieaesskkeenkeknReinivaversRvklsplpgkdgkDYinAsyid----GyrrskeyivtqgplketiedFWrmiWehnaqiivm LTTQVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRP--LTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVV | .|.|| ....|||. .. ... ..|| |.| |. |...| |....... .| .| |||.|.|. . ..| || .. . . |.|||. ltdldekgrrdedvyWPkkdeplelealkvtllskeklskytvrdfvlkntkddkekervvrqyhytkWPdmgsPestlfvlifvkkeeaankeeaGPiv VHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV ||| ||.|..| ..| . .| .. | .......| .| ....| ||.|. .|.|.. vhdsaGvgragtyialdtllqqlekeeavnvyqvlklirakRpglvtteEqyvfiydallel |
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| Phosphatase | PTPN4.AA | Subfamily.RN.PD | 665-909 | 39 | 8.4e-58 | 187.1 | In-house | 14-260 (264) | Show / Hide |
Range on Protein: 665-909 Range on HMM: 14-260/264 Sequence Identity: 39% (98 aa) KKPgMTMSCAKLPQNISKNRYRDISPYDATRVILKGN-----EDYINANYINMEIPSSsiiNQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERG .| | . || ..|..|||.... ||| .|| || . .||||| | . | . |||.||||..| .||||| ||||. ..|.||. | | aep-stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdpra---payiatqgplsstiadfwqmvweqGvvvivnltrleeeg RVKCHQYWPEpTGSSSYGCYQVTCHSEEG-NTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGR .|..|||. .||. |. |.| || |. | . | | ...|.| .|| ...||..||| . .|.| | |.|.|||||.| ||||| vkqckrywpd-eGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGr TGVLITMEtaMCLIECNQPVYPLDIVRT---MRDQRAMMIQTPSQYRFVCEAIL | .. . | .. | .||. | .||||. ...| .|..|. |. tGvyilid--lvlerllkGvkeidiaatlehlrdqrpglvktkdqfefaltava |
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| Phosphatase | PTPN4.AA | Subfamily.R_Ecdysozoa.PD | 658-910 | 31 | 9.6e-58 | 186.8 | In-house | 5-266 (269) | Show / Hide |
Range on Protein: 658-910 Range on HMM: 5-266/269 Sequence Identity: 31% (84 aa) QFDQLYRK-KPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNE-----DYINANYINmeipSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVM ...| .. . . . .. | ||||.|| ..| |||.|| . |||||..|. . ...|| |.|. | |||.| .|| . ..||| eyekLearleiskstkvsekkenalknryedikafDktrvkLkkingkedsdyinasfik----gykekkkfiaaqdPveatigDfWrmiaeqevtlivm LTTQVERGRVkCHQYWPEPtGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQE---KNESRPLTQIQYIAWP-DHGVPDDSSDFLDFVCHVR-----NKRA . | | |..|||. || |.. ||| . || |.... ... ..|| ..| .| .|. | ||. . |... .|| || .| lsnlteknrk-cakyWpie-devqygdilvklvseekhsdyiireldvskkkeesvedsrkvvqysytgWksDskvPevargllklieqvrelyklnkls GKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK . |.||||||| ||.|...... . .. .. | ...|. .| ||....||| |. |... gsrsPivvhCsaGvgrsgifvaldlllqqlkaedkvdifetvkkLrsqrnllvqsleqyvflyralad |
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| Phosphatase | PTPN4.AA | Subfamily.N23.PD | 691-910 | 32 | 4.9e-57 | 184.9 | In-house | 114-347 (350) | Show / Hide |
Range on Protein: 691-910 Range on HMM: 114-347/350 Sequence Identity: 32% (76 aa) YDATRVILK------GNEDYINANYINMEIPSSsiiNQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGS-SSYGCYQVTC | .|| |. ..||||| |. | | ..|| |||.. | .|||.| ||| ||..||||..||... ||.||||. .| ..| ..|... hdpnrvklqqstqpgqqddyinatylkeltpms---PpfiatqgPiastlaDFWlmvweqqssviVmltkevegnklkcdqYwPidegetnlfgdlrvsl HSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKR-----A----GKEEPVVVHCSAGIGRTGVLITMETAMCLIEC |.. .| |...| .. . | ...... .|...|||. .|.|.|. |.. . ..|...|||||.||||.. . .|. .. . kslrssegwiervlhlqhndvstvrlvchlhtttWseiGvPksPedllaflgevetayaqqrktetegeggkPiilhCsaGvgRtgtfcvvysairelta NQPVYP-LDIVRTMRDQRAMMIQTPSQYRFVCEAILK ... ...||..| || |.|. ..... ||.|. gngiiniprvvrrlrqqRkymvqkkvilkklyeavle |
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| Phosphatase | PTPN4.AA | Subfamily.N20.PD | 667-911 | 38 | 3.1e-56 | 182.2 | In-house | 15-255 (257) | Show / Hide |
Range on Protein: 667-911 Range on HMM: 15-255/257 Sequence Identity: 38% (95 aa) PGMtMSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINMEipSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQY || . . . | | ||||||| |||.||| | ..|||||.|| . ||| |||| | ||||| |. | .. |.| ..| |.||..|| pge-fnsgnqpsnreknryrdilpydstrvplgkskdyinasyiriv--ncgeeyfyiatqgpllstiddfwqmvlennsnviamitreieggiikcyhy WPEPTG-SSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRagKEEPVVVHCSAGIGRTGVLITM | ..| . .| | . . .. |. . |.|. ||||| | . |. .. . |. . |.|||||||||||||.. .. wpislkkplelkhfrvflenyqilqyfiirmfqvvekstgtshsvkqlqftkwpdhgtpasadsfikyiryarksh--ltgpmvvhcsagigrtgvflcv ETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV .| | | . .||| ||.||. |.|| ||.|. . .|.| dvvfcaivkncsfnimdivaqmreqrsgmvqtkeqyhfcydivlev |
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| Phosphatase | PTPN4.AA | Subfamily.N_Nematode_1.PD | 658-910 | 31 | 2.4e-50 | 162.6 | In-house | 5-262 (265) | Show / Hide |
Range on Protein: 658-910 Range on HMM: 5-262/265 Sequence Identity: 31% (83 aa) QFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVIL---KGNEDYINANYINMeiPSSSiiNQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTT .| .| . .. ... | |. .||||.|.. | .||.| ||| |||. . |. . ...| .|.|| .|..|||| . ..||| efralkkfndeekvkafkeaqeadknrykdvgcldknrvklaeeplpsdyihanyvgt--ptnp--krficaqaPldktiadfwymvlqekveaivmlck QVERGRVKCHQYWPEPTGSSS-YGCY--QVTC------HSEEGNTAYIfrKMTLFNQE--KNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRag .|.|..||..|.| .|. . ..| . | . . | |.| .. | ...| .|..|.. |||.||| |... .||... liekgkkkcaeyfpakegeklefkekgqkitvenslgvkkleedeevi--kvtvlevegaGektrkvthyqWtdWPdrGvPpadlaalelleavrgsk-- keEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPL-DIVRTMRDQRAMMIQTPSQYRFVCEAILK .|.|||||||||||| ....| . . .. . . ..|. .|.||..||| || || .|. --gPivvhCsaGiGrtGtivaieyildkllegkqiedmeklvkkireqrnysiqtdaqylfvhrvlln |
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| Phosphatase | PTPN4.AA | Subfamily.N_Nematode_4.PD | 664-908 | 34 | 3.7e-50 | 162.1 | In-house | 13-259 (264) | Show / Hide |
Range on Protein: 664-908 Range on HMM: 13-259/264 Sequence Identity: 34% (86 aa) RKKPGMTMSCAKlpQNISKNRYRDISPYDATRVILKGN---EDYINANYINMEipsssIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGR ...| .|.| . .| ||||.|| |.|||.|| . .||| |... | .||..||||..| .||| | .....|||| . .| | | kappnvtasase--knsdknryadilcidetrvvlknrdpdndyihaswmrmP-----dkfryistqGPlketlsdfwhmvytekiavvvmlcdlieegv VKCHQYWPEPTGS-SSYGCYQVTCHSEEGN--TAYIFRKMTLFNQEKN---ESRPL--TQIQYIAWPDHGVPDDSSDFLDFVCHVRNkrAGKEEPVVVHC | .|.|| .. .| |..| .. . . |.. ... | ||. |.|| .|. |.|. | |. ... |.. ||.|.|||||| ekcaryypeksekvvkfGkyritlvekkeeviadvilnslkvtntekkkdapseplvvkhvqvdwwrdqvaPldaapviklykavkk--kkkekPivvhc SAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAI |.||| |. .. | | | . ||||| .| | .|. |. |.. saGvGrtatlvGidyatirirenseievldivrelramrlkavqshlqflfllvvl |
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| Phosphatase | PTPN4.AA | Subfamily.RC.PD | 656-912 | 31 | 1.4e-49 | 160.2 | In-house | 3-287 (288) | Show / Hide |
Range on Protein: 656-912 Range on HMM: 3-287/288 Sequence Identity: 31% (89 aa) LTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKG---------------NEDYIN----ANYINME-IPSSSIINQYIACQGPLPHTCT ...| .| . . .|. |. ..| ||||| |. ||| || || ..| |. ..||| | | ..||| |||| | eaefqrlpsvrskrtikiarkeenksknrysdvlpydynrvelkhelemskesehdsdessdddidseegskyinasfidsykkpekyiaaqGplketvd DFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWpePTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVC |||.| .|. ..|||| | | || .|| | .|| .| . .. . ||.||. | |. . .|| .||||| .|.....|.. .|... dfwrmiferkvkvivmltelkeGdrekcaeyw--eeGkrayGdvevdlkdtdkssdyilrklelvnkkrkdsrevtqiqytswsveqlpeepkellkliq HVRNK----------RAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVY |..| . | |..|||..| .|||. |.... . .|... | ..|. .| .|..|... || .. ... ..| vvkqklpqkrsseafknfkstpllvhcrdGsqrtGifiallallesleaeekvdvfqvvkklrkarplmvsveeqyillydvlvety |
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| Phosphatase | PTPN4.AA | Subfamily.R_Nematode_2.PD | 665-905 | 33 | 1e-44 | 144.2 | In-house | 17-253 (261) | Show / Hide |
Range on Protein: 665-905 Range on HMM: 17-253/261 Sequence Identity: 33% (79 aa) KKPGMTMSCAKLPQNisKNRYRDISPYDATR--VILKGNEDYINANYINMeipsSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVK .| ..| | | ||.. |.|| |. . |. || .|. | ||... .. ...|| |||| |. ||| | ..|||. .||. . ||..| dkesvtesaaylpkd--khRypdvPCkpetavevivdgkrvpihanwvpt----agnpkrfiatqgPlentsedfWamviqekvekivmlcqkvekekek CHQYWPEPTGS-SSYGCYQVTCHSEEGNTAYIFRKMTLF---NQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNkragKEEPVVVHCSAGIGR .| |.. . | .... |.| | || .. | ..| .| || |||.|||.. . . |.. |.|.|||||||||||. .|.. ceeYfpletsqkldlgrfsiktvsaekilkdeiekrtlkvedstgkfatrtvthyqyeeWpdrgvPkshaelfeLlelvkk----sekPivvhCsaGiGR TGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVC | .| .. . . .. .|..| . ||| ||. .. tmafigteylareveadptieltealkelrehRwkgiqtesqlywlt |
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| Phosphatase | PTPN4.AA | Subfamily.N_Nematode_6.PD | 671-909 | 27 | 3.7e-42 | 135.9 | In-house | 16-249 (253) | Show / Hide |
Range on Protein: 671-909 Range on HMM: 16-249/253 Sequence Identity: 27% (66 aa) MSCAKLPQNISKNRYRDISPYDATRVILKGNED-YINANYINMEIPSssiiNQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPE .. . .. .|||..| .||.|. |...|| || ||.... . ...| .|.|| |...||.| .|. ..|||||.|. |. .| .. | seataflkfkdrnrytniqCcdagrlkladdedfyihanlvkistkp----rrlictqaplegtieefwkmilssgveyivmlcelvekgkeksaeylsd PTGSSS-YGCYQVTCH-SEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRagkeEPVVVHCSAGIGRTGVLITMET . .. . . ... . | . .. .|. . |.. .||||||||. | ..|.... |.|||||||.|||| |. ..... . kvGdarkitklctvikigrkdidkilvrslkrivkagdeevivkhihWanWPdhGvPdsflsalrllsvvkkdk----kPivvhCsaGvGrtGtlalili AMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAIL . |.. .|..|. .|| || .. .| ilealrlpdfqgvkdllvklreerfravqtevqylyalrcvl |
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| Phosphatase | PTPN4.AA | Subfamily.R_Nematode_3.PD | 663-911 | 26 | 2.3e-41 | 133.3 | In-house | 10-265 (267) | Show / Hide |
Range on Protein: 663-911 Range on HMM: 10-265/267 Sequence Identity: 26% (71 aa) YRKKPGMTMSCAklpQNISKNRYRDISPYDATRVILKG-----NEDYINANYINMeiPSSsiiNQYIACQGPL--------PHTCTDFWQMTWEQGSSMV . .. ...| ...|..|. ... . .|||.||| ..|.|.||.... |.. .. | |.|. |. ||.| .... | aklakknatsls---kkvsedrrvevpllektrvvLkgygkrfkddfihAnvvec--png---lklIltqsPqkkdkekkkkstieKfwwmieqekveqv VMLTTQVE---RGRVKCHQYWPEPTGS-SSYGCYQVTC--HSEEGNTAYIFRKMTLfNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRag ||| || .. || .|.|| . . ..|.| ..| . |.... . ||.. |.| .|.....|... .|. . |.. . vmlcdfveedgeeeekcseYypekvdgelkfegvsvkctdikkelsedvekrtlvv-tfekkkeftvthllykgWkelnapeepkealelikfveksk-- keEPVVVHCSAGIGRTGVLITMETAMCLIECNQ-PVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV |||||||.||.|...| .| .. || .. . |... .| |||.|||.... || |||. --tpvvVHCsdGisRsatlaaielgyqliikskgkldllslikelrkqRagaiqtelelafvilgilkl |
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| Phosphatase | PTPN4.AA | PTPc_motif | 809-910 | 37 | 3.2e-40 | 140.85 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 809-910 Range on HMM: 1-92/92 Sequence Identity: 37% (40 aa) PLTQIQYIAWPDH-----GVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRF ... .| .|||| |||. ...|.|. |||. |.|||||||.||||........|.. | ...|. ||.||..|.|| ||.| TVHHYHYTNWPDHVEKDSGVPE--DSILEFIRHVRK-------PIVVHCSAGCGRTGTFCAIDMMMQQ------VDIFQTVKEMRKQRPGMVQTEEQYIF VCEAILK ....||. CYRCILE |
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| Phosphatase | PTPN4.AA | Subfamily.N_Nematode_5.PD | 657-910 | 26 | 5.3e-40 | 128.6 | In-house | 4-255 (258) | Show / Hide |
Range on Protein: 657-910 Range on HMM: 4-255/258 Sequence Identity: 26% (67 aa) TQFDQLYRKKPGMTmSCAKLPQNISKNRYRDISPYDATRVILK-GNEDYINANYINMEIpsssIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQ |.|..| || . .| . .|..|||. |. .|.|||.|. ....||||..|... . ...| | |||.| |||.| .. .||.|... tefeklaslkpnke-tckafeknlkknrskdvkilDetrVkltdeddsYinaskikldd----lekkliltQlPlpdteedFWrmvyqekitsvvllved VERGRVKChQYWP-EPTGSSSYGCYQVTCHSEEGNTAY-IFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLD-FVCHVRNKRAGKEEPVVVHC | . .. ...| | . .| ... | .. .. .. ....|| .. .. |...|||.... . . .| .| ||..||||... eelketav-sffpletgdylnlgkmfinnrkvevkedekkeytvevlpegcsesvfakvyhlttWkkkkvPdkvkkvikraiekvlskkqgknapvvvvs SAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK .|.||.| ......|.. .. .. . .|....|.||. .... .|| .|.|.|. dlGlgRagtflllsvaieqlnngkepnideilkkirsqRpgavesliqyasvyaavld |
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| Phosphatase | PTPN4.AA | Subfamily.N_Fungi_PTP1.PD | 678-771 | 35 | 3.2e-27 | 86.8 | In-house | 44-152 (343) | Show / Hide |
Range on Protein: 678-771 Range on HMM: 44-152/343 Sequence Identity: 35% (38 aa) QNISKNRYRDISPYDATRVILK-------------GNEDYINANYINMEIPSSSIINQY--IACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVK . .||||..| ||. .||.|| .|||||||.... .| .| .. || |.||| | ||... . .....||..|| .. ||. elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek CHQYWPEPT .||.| . cyrYWqegs |
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| Phosphatase | PTPN4.AA | Subfamily.N_Nematode_egg.PD | 658-910 | 23 | 3.8e-27 | 86.7 | In-house | 5-254 (257) | Show / Hide |
Range on Protein: 658-910 Range on HMM: 5-254/257 Sequence Identity: 23% (61 aa) QFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKG-----NEDYINANYINmeipSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVML .|..| | .... | .. | | . . . .|| |. .|.| ||... ..|..| .| || ||||.| ... .||||. rfeilersvdeislttaasdnylekarskrvhckessrvklelrrGqylddfihanrvk----Gkpllnefilaqaplkntvedfwrmvfqekvqyivml TTQVERgrVKCHQYWPEPT-GSSSY--GCYQVTCHSEEGNTAYIFRK--MTLFNQEkNESRPLTQIQyiaWpDHgvpDDSSDFLDFVCHVRNKRAgKEEP ..| .|. ||| | . | ..... . .. .|| . | . .| . || . | . .|| . .| | .||||.. tsakes--erceyywpkaeseslvtvpGslrienlkvdskadplfrvtklklvGgd-deelflehwq---g-dv---nylsdvysplrvlrklrn-lskp VVVHCSAGIGRTGVLITMETAMCLIECNqPVYPLDIVR---TMRDQRAMMIQTPSQYRFVCEAILK |. ....|...|.|.. . |.. . | .| .| . .... .| || .|. vvvqdilGvskaatlvaieiallsllrG-pitkslvlravvflrlrrrlsvesvllylfvyrlvlf |
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| Phosphatase | PTPN4.AA | Subfamily.N_Nematode_eak.PD | 662-834 | 24 | 1.1e-18 | 58.9 | In-house | 9-179 (281) | Show / Hide |
Range on Protein: 662-834 Range on HMM: 9-179/281 Sequence Identity: 24% (41 aa) LYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNEdYINANYINMEIPS-SSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGR | .... .... .. ... .|| .| |.| | | . ||| . | . ..|| . . |||||| | .|.| .|| . | lddyqrllsirvtarleavnrnrvvkivpqdrylvrltssq-lnrdGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledveekl VKCHQYWPEPTGSSSYGCYQVTCHSEEGNtAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDdSSDFLDFV .|.|. | .|| ..|.. . . |.. | . ||. . .. | . .|||| . eksdkyfpdktevlkyGildverkeyavk-rniletrllilrkGnethrvlhykvfGwtettlpk-yedflalr |
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| Phosphatase | PTPN4.AA | Subfamily.N_Fungi_PTP1.PD | 812-911 | 28 | 1.8e-11 | 35.0 | In-house | 217-341 (343) | Show / Hide |
Range on Protein: 812-911 Range on HMM: 217-341/343 Sequence Identity: 28% (32 aa) QIQYIAWPDHGVPDDS----------SDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLITMETAMC---LIE-C-------NQPVYPL----DIVRT |.|. |.| .. . .|..| . . .|..||||||.||||.|.|.. . .|... || .| || |. qlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivne MRDQRAMMIQTPSQYRFVCEAILKV |. |. |. ||.| lrkqrismvqnldqfifiYeallfy |
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| Phosphatase | PTPN4.AA | Family.DSP.PD | 743-900 | 18 | 2.3e-11 | 35.0 | In-house | 130-234 (387) | Show / Hide |
Range on Protein: 743-900 Range on HMM: 130-234/387 Sequence Identity: 18% (31 aa) EQGSSMVVMLTtqvergrvkchqywpeptgsssygcyqvtchseegntayifR------KmtlfnqeknesrpLTQIQY--IAWPDHGVPDDSSDFLD-- | | ...| || | .|.| |...||..|. .. ||.. elgvtkivnlt-----------------------------------------ddkpqftk-------------elgikylripidDhnapplenlfekai -FVCHVRNkragKEEPVVVHCSAGIGRTGVLItmetAMCLIECNQPVYPlDIVRTMRDQRAmMIQTPSQ ... ... |.||| ||.||.|.|| . |..... .. . .. .|..| . ||.| dfieegnd----skgvVlVHCkaGkgRsgtli----iaYlmksegltle-ealdwvrskRp-gvitpnq |
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| Phosphatase | PTPN4.AA | Subfamily.PTPDC1.PD | 815-905 | 31 | 4.3e-11 | 34.1 | In-house | 139-221 (229) | Show / Hide |
Range on Protein: 815-905 Range on HMM: 139-221/229 Sequence Identity: 31% (28 aa) YIAWPDHGVPDdSSDFLDFVCHVrNKRAgKEEPVVVHCSAGIGRTGVLITmetamCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVC ....|.||. || | | . .| . ||| || |||||||. | . .. . . . ....|..|. ||| .| ..| nfglkDygvas-leriLdivkvv-dfal-eegkiavHCHAGlGRtGvlia-----cylvyakrltaeeaiklvrskrpksiqtreqvelve |
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| Phosphatase | PTPN4.AA | Subfamily.PTEN.PD | 799-904 | 27 | 8.3e-09 | 26.6 | In-house | 48-152 (305) | Show / Hide |
Range on Protein: 799-904 Range on HMM: 48-152/305 Sequence Identity: 27% (29 aa) LFNQEKNESRPLTQIQYIAWPDHGVPDdSSDFLDFVCHVRNK-RAGKEEPVVVHCSAGIGRTGVLITMeTAMCLIECNQPVYPLDIVRTMRDQRAMMIQT ...||..| .... . || | . ..| .| . . |.. |.||| || |||||.|. . .... |.| .|. . || nargekedsdfdgrvavypfdDhnppt-leLleeivedvdkwLkedksnVvavHCkaGkGRtGvmica-yLlksgikksadealaiydekRtkdkkGVti PSQYRFV | |.| PSQrRYv |
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| Phosphatase | PTPN4.AA | Subfamily.DSP23.PD | 804-904 | 28 | 3.5e-08 | 25.0 | In-house | 27-120 (128) | Show / Hide |
Range on Protein: 804-904 Range on HMM: 27-120/128 Sequence Identity: 28% (28 aa) KNESRPLTQIQYIAWPDHGVPddSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLItmetAmCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRF ..|. | .. | ||. | . . .. . .. .. |||.| ||| |.|||| |. | | . .. . | . .| .||.| | . | yseaapsltlrridipdfcPP--aleqvarlvriveeaekkeeavgvhcalGlGrtGtll----a-cylvkeeglaaddaiaevrkrrkGsietveqeka V v |
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| Phosphatase | PTPN4.AA | Subfamily.TPIP.PD | 812-905 | 25 | 7.8e-07 | 20.3 | In-house | 4-101 (245) | Show / Hide |
Range on Protein: 812-905 Range on HMM: 4-101/245 Sequence Identity: 25% (25 aa) QIQYIAWPDHGVPDdSSDFLDFVCHVRNKRAGKEEP-VVVHCSAGIGRTGVLITM--ETAMCLIECNQPVYPLDIVRTMRDQRAMM--IQTPSQYRFVC ... | || || .... | .|.. | .| |..|| | |||| .. .. . . .. .. . || ... . ..||||.|.| rvsrimiddhnvPt-leelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryvg |
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| Phosphatase | PTPN4.AA | Subfamily.PRL.PD | 840-897 | 34 | 1.7e-06 | 19.3 | In-house | 77-127 (140) | Show / Hide |
Range on Protein: 840-897 Range on HMM: 77-127/140 Sequence Identity: 34% (20 aa) KRAgKEEPVVVHCSAGIGRTGVLItmetAMCLIECNqpVYPLDIVRTMRDQRAMMIQT |.. ... | ||| ||.||. ||. |..|||. . . | | .|..| | . kee-pkstvavhcvaGlGraPvlv----alalieaG--mkyedavefirekrrgains |
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| Phosphatase | PTPN4.AA | Subfamily.Tensin.PD | 812-904 | 28 | 1.8e-06 | 18.9 | In-house | 4-97 (237) | Show / Hide |
Range on Protein: 812-904 Range on HMM: 4-97/237 Sequence Identity: 28% (27 aa) QIQYIAWPDHGVPddSSDFLDFVCHVRNK--RAGKEEPVVVHCSAGIGRTGVLITMETAMCLIeCNQPVYPLDIVRTMR--DQRAMMIQTPSQYRFV ... . |||. | . . | .|. . | .. ||.|| | ||.|| |. | .. . ||.. | |.. . ..||| |.| kvldlGWPdllaP--pleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyski-sasadaaldrfalkrfyddkvsgvtqPsqrryv |
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| Phosphatase | PTPN4.AA | Subfamily.DSP11.PD | 816-864 | 34 | 5.3e-06 | 17.7 | In-house | 50-100 (141) | Show / Hide |
Range on Protein: 816-864 Range on HMM: 50-100/141 Sequence Identity: 34% (17 aa) IAWPDHGVPD--DSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLIT . | | ||. | ..| ..| . .|.. ... . ||| |. ||| || lncpGhevpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliC |
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