Gene PTPN11
PTPN11
Species: Human
Alias: BPTP3, MGC14433, PTPN11, PTP-1D, CFC, PTP2C, NS1, SHP2, SH-PTP3, SH-PTP2
External Links:
COSMIC
,
Entrez Gene
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of PTPN11.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| SH2 | PTPN11.AA | SH2 | 4-87 | 40 | 3.3e-32 | 114.22 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 4-87 Range on HMM: 1-87/87 Sequence Identity: 40% (36 aa) RRWFHPNITGVEAENLLLTR-GVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG-DYYDLYG--GEKFATLAELVQYYMEHHGQ |.| ||.. |||.||... . ||.|| |.| |||||..|||| .| | |..|. .. . | . . ..|| .| |||..|. . . QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG |
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| SH2 | PTPN11.AA | SH2 | 6-81 | 46 | 2e-44 | 132.25 | Pfam | 1-81 (81) | Show / Hide |
Range on Protein: 6-81 Range on HMM: 1-81/81 Sequence Identity: 46% (38 aa) WFHPNITGVEAENLLLT-RGVDGSFLARPSKSNPGDFTLSVRRNG---AVTHIKIQNTGDY-YDLYGGEKFATLAELVQYY |.|..|.. |||.||. .. ||.|| |.| |.|||.|||||..| |.|..||.|.. | ..|..||..|.|||..| WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY |
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| SH2 | PTPN11.AA | SH2 | 110-203 | 40 | 4e-37 | 130.56 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 110-203 Range on HMM: 1-87/87 Sequence Identity: 40% (40 aa) ERWFHGHLSGKEAEKLLTEK-GKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQE-LKYDVGG--GERFDSLTDLVEHYKKNPMV . |.||..|..|||.|| ...|.||||.|.|.|||.|||||.. .|| | ||... || ... ...|.|| .||.||..|| . QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK----------GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG |
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| Phosphatase | PTPN11.AA | Subfamily.N6.PD | 244-523 | 64 | 1.4e-135 | 442.7 | In-house | 11-295 (295) | Show / Hide |
Range on Protein: 244-523 Range on HMM: 11-295/295 Sequence Identity: 64% (182 aa) KQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPK-----KSYIATQGCLQNTV |||||||.||.||.. |||||||...|||.|||||||||||||||.|.||.|. | ||||||| | . ..|....... |.||||||||..||.| tlgfweefeelqkqeseklysrkegekienkeknryknilPfDhtrvilkdgepsvpgsdYiNanyirlpkaskssgenveseehqkryiatqgcLkdtv NDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDF |||||.||||||||||||||||||.||..||||| ||.||..|....|.. .||||||...|. . ...|...||||..|||||||.||| ||.||| sdFWrmvwqensrvivmttkevergknkCarYWPdeetkketGvitvtsisEkstadYtlRefsvshkdkdkeareifqyhfkaWPdhgvpkdpgvvlnf LEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIE .|..|||....|||.|||||||||||||||||||...||...|.|.|||. |.|..|||||||.|||||||.|.|.|||.||| ledvnkkqeelekagpivvhcsaGiGrtGtfividivlkiieqsgldvdidisksikdvrsqrsglvqteaqykfvykavqfyie |
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| SH2 | PTPN11.AA | SH2 | 112-197 | 42 | 1.8e-43 | 129.43 | Pfam | 1-81 (81) | Show / Hide |
Range on Protein: 112-197 Range on HMM: 1-81/81 Sequence Identity: 42% (37 aa) WFHGHLSGKEAEKLLTE-KGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELK-YDVGGGERFDSLTDLVEHY |.||..|..|||.|| . ...|.||||||.|.|||..||||.... ..|.| |.... . | ..|...|.|| .||||| WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP-------GDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY |
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| Phosphatase | PTPN11.AA | PTPc | 246-523 | 38 | 4.2e-137 | 462.71 | SMART | 1-308 (308) | Show / Hide |
Range on Protein: 246-523 Range on HMM: 1-308/308 Sequence Identity: 38% (124 aa) GFWEEFETLQQQECKLLY-------SRKEGQRQENK--NKNRYK-NILPFDHTRVVLHDGD---PNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQG |||||||.||... ..|. | ......||. .||||| .|...|||||.|.... .... ||||||| |. . . .|.||.||| GFWEEFERLQRMTPWDLMSNYDPCCSCTCACWPENREMDKNRYKCDIPCYDHTRVKLKPPPGESHCYEGSDYINANYIDGY--------WRPKRYICTQG CLQNTVNDFWRMVFQENSRVIVMTTKEVER--------GKSKCVKYWPDEYALKEYGVMRVRNVKESAAH-DYTLRELKLSKVGQG-------NTERTVW .|..|..||||||.|.....||| ....|. |. || .||||| ..|| ..| ...| |||.|...... |.. . .|||. PLPHTIEDFWRMVWQQKCHIIVMLCNCMEKCTENRDQNGREKCHQYWPDE--PMTYGHITVTCKSEEKCPDDYTMRTFEVTNTGCNCKYSMACSETRTVT QYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMD-----------------AGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRS .||. .|||||||..| ..|||...|.|.|.. .. .||.|||||||.||||||..|||... |.. .|......|.|. HYHYTNWPDHGVPESPDSFLDFIRQVRHWQSHSPNMYMNMVSSNSKYHHTCPTGPIVVHCSAGCGRTGTFCAIDIMCQQIEN------VDIFQIVKMMRN QRSGMVQTEAQYRFIYMAVQHYIE || ||||||.||.|.|.....||. QRPGMVQTEEQYIFCYRCILEYIK |
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| Phosphatase | PTPN11.AA | Y_phosphatase | 273-520 | 43 | 1.2e-117 | 402.0 | Pfam | 1-243 (243) | Show / Hide |
Range on Protein: 273-520 Range on HMM: 1-243/243 Sequence Identity: 43% (111 aa) NKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGK-SK-CVKY ||.|||||.|...|||||.|.. |... ||||||| |. ... .| ||.||| ...|..||||||.|.....||| ....|.|. | | .| NKEKNRYKDIPCYDHTRVKLQPI-PGDEDSDYINANYIDG-------PYWNPKAYICTQGPMPHTIEDFWRMVWQQKCTCIVMLCNCMEMGRDEKTCHQY WPD--EYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQ-GNTERTVWQYHFRTWPDHGVPSD-PGGVLDFLEEVHHKQESIMDAG--PVVVHCSAGIG ||| | ..|| ..| .|.| .|||.|...... | .. .|||..||. .|||||||.. | ..|||...|...|. |.| |.|||||||.| WPDNKEGQPMTYGDFQVTCVSEEHCPDYTVRTFEVTN-GDQKQETRTVTHYHYTNWPDHGVPESQPKSMLDFIRQVRKWQP-NPDHGCPPIVVHCSAGCG RTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQH |||||..|||... ....|. |........|.|| ||||||.||.|.|..... RTGTFCAIDIMCQQMEHEGTV---DIFQIVKHMRNQRPGMVQTEEQYIFCYQCILE |
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| Phosphatase | PTPN11.AA | Subfamily.R_Anemone_2.PD | 247-522 | 43 | 1e-84 | 275.7 | In-house | 2-261 (262) | Show / Hide |
Range on Protein: 247-522 Range on HMM: 2-261/262 Sequence Identity: 43% (119 aa) FWEEFETLQQQECKLlYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGdPNEPVSDYINANIImpefetkcNNSKPKKSYIATQGCLQNTVNDFWRMVF . ||.|.|...| . . |. ... ||.|||| |||..|.||| |.. .|. ||||||| | . . ||.|||||. | .|..||||||. lseeyerlsrseets-vtlksalepvnkaknryanilaydktrvklqml-egeegsdyinanyi--------dGyrrkkayiatqaPlpetiedfWrmvW QENSRVIVMTTKEVERGKSKCVKYWPDEYAlKEYGVMRVRNVKESAAHDYTLRELKLSKVGQgNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQ . ||.|||| |.|.|||| |. .|||.. . ..||...| .| ||.||..|... .. . ||.||.|. .|||.|||......||.. .|.. |. eqnsavivmltqeeergkakvhryWPskgs-rsygklvvelkeevelsdyvlrsfkvkrtee-eeerqvrqfhytsWpdegvpesgaslldlvrqvekaq ESiMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI . .|||.|||||||.||||.||..|||.. |.. .. .|| .|....|.||. ||||. || ||| ... .. qe-sgagpivvhcsaGvGrtGvfiavdillerikaeal---vdvfqtvkqlreqrnlmvqtkdqyefiydvlleal |
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| Phosphatase | PTPN11.AA | Subfamily.RB.PD | 249-522 | 41 | 1.5e-82 | 268.4 | In-house | 4-260 (261) | Show / Hide |
Range on Protein: 249-522 Range on HMM: 4-260/261 Sequence Identity: 41% (114 aa) EEFETLQQQECklLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDpNEPVSDYINANIImPEFETkcnnskpKKSYIATQGCLQNTVNDFWRMVFQE ||.|.|.. . . |. ....|..|||..||||.||.|| |.. . .|. .|||||| | |.... .. |||||| |..||.||||||... eeyeelkkvgk--dqavkaaeeavnraknrftnilpydhsrvkLaalk-desdtdyinanyi-pgyns-------preyiatqGPlpetvddfWrmvwek NSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKvgqGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQES .|..||| |. ||.|| || .|||... || ..| ..|. .....||.|..| |...|.| |||| .|||||||... .|||...|... |. kssiivmltqlvEkgkekceeYWPadeepvlyGdikvtllaekeldewvirefkiek---gkekrkvrqyhftsWpdhgvPektktlldfvrtvreaiek IMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGvdcDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI . ..|.|||||||.||||||| .| |.. |.|. .|| .. .|..| .||||.|| ||. ...... kaskkPivvHCsaGvGRtGtfialdrllqaieend---yvdvfgvvaelReeRnllvqtekqyifiheclldll |
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| Phosphatase | PTPN11.AA | Subfamily.N12.PD | 249-522 | 39 | 6.6e-82 | 266.1 | In-house | 4-269 (270) | Show / Hide |
Range on Protein: 249-522 Range on HMM: 4-269/270 Sequence Identity: 39% (111 aa) EEFETLQQQECK----LLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEpVSDYINANIImpefetkcNNSKPKKSYIATQGCLQNTVNDFWRM .||..|.... | ||...|...||..|||||.|||.|..||.|. . .| |||||||.| .... |..|||.|| | .|..||||| kefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeee-gsdyinanfi--------kgvegkleyiaaqgPLpktlddfWrm VFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKE-YGVMRVRNVKESAAH-DYTLRELKLSKVgqgNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEV ... | ...|| .||| || || .|||.| . .| ..| . .| | . |...| ||. . ...|.| |.|.. |||||||| . .|...|.| iweknveivvmaCrevelgkkkCeryWpeegeeelefgefevtleeekavdddflirtLkveaq---kesrkvyqfhytaWPDhgvPssaksllelielv HHKQEsiMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI .. || .. |.|||||||.||||| |.||. ...... .. ..|| . .. .| ||. .|||. ||...|.||.... relqe--sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv |
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| Phosphatase | PTPN11.AA | Subfamily.R_Anemone_1.PD | 249-522 | 41 | 1.4e-80 | 262.1 | In-house | 4-257 (258) | Show / Hide |
Range on Protein: 249-522 Range on HMM: 4-257/258 Sequence Identity: 41% (113 aa) EEFETLQQQECkllYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDpNEPVSDYINANIIMPEFetkcnnskPKKSYIATQGCLQNTVNDFWRMVFQE .||..|.... . . ....|||.||||..|...||.||||.. . |.. |||||| . ....||||..|..||.||||||.|| aefqrlkeike---eekevarkaenkkknryadivaldhsRvvLekls-ndeesdYinasylrasd--------ktrafiatqapleetvedFWrmvwqe NSRVIVMTTKEVERGKSKCVKYWPDeyALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGnTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKqeS .. |||| | .| |.|| .|||| ..|| .||. |. . ||..|.|.|||... .||.| |||| .|||.|||. ||.....|... | kigviVmLtnliegekkkchqYwPd--stekygelrvslrkkevfadyiirtlvlskkket-eerevvqyhftvWpdkgvPqyatavLglrrkvqks--s IMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI .| |||||||||.||||.|.||| ... .... | .|. ......|..|||||. || ||..||.... lagarpvvvhCsaGvgRtGaflvidamleqakkekv---vDifnyvkairedrphmvqtkeqyvfihlavleal |
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| Phosphatase | PTPN11.AA | Subfamily.RA.PD | 247-522 | 38 | 7.7e-79 | 256.3 | In-house | 2-265 (266) | Show / Hide |
Range on Protein: 247-522 Range on HMM: 2-265/266 Sequence Identity: 38% (109 aa) FWEEFETLQQqeCKLL-YSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDpNEPVSDYINANIImpefetkcNNSKPKKSYIATQGCLQNTVNDFWRMV . |||..| . .|. . . ....|||.|||. .|||.|..||.| . |. |||||| | . . |...||.|| ...||.|||||. leeefkklts--vkiqkeklrtankeenkkknrvvqilpydfsrvilsvke-Geeesdyinasfi--------dGyrekdkfiaaqGpkeetvedfwrmi FQENSRVIVMTTKEVERGKSKCVKYWPDEYAlKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGN---TERTVWQYHFRTWPDHGVPSDPGGVLDFLEEV .. .| ||| |. ||...|| .||||| . || .|| .| . |||.|.. . .... ..| | |.||..||. |||... |.|..|..| weqksativmltelkerkeekcaqywpdeGl-vtyGeirvevkdetvledytvrdflvtqlpdatrekksrlvrqfhftswpevGvpaegkGmlkllkkv HHKQESiMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI ...|. . . |.|||||||.||||||||.| ... .. ... .|| .... .| ||. ||||. || ||| ....|| kklqqq-sanhpivvhcsaGvGrtGtfivldavlervkaerk---ldvfeavkrlrlqrpqmvqtleqyefiykvlleyi |
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| Phosphatase | PTPN11.AA | Subfamily.R_Sponge_2.PD | 264-523 | 40 | 1.6e-75 | 245.4 | In-house | 16-262 (262) | Show / Hide |
Range on Protein: 264-523 Range on HMM: 16-262/262 Sequence Identity: 40% (106 aa) SRKEGQRQENKNKNRYKNILPFDHTRVVLHDgdPNEPVSDYINANIImpefetkcNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERG | .... .||. |||.|.|||.|..|| |. .... ||||||. . . | .|.|||||| |..||.||||||. ... ||| |. .|.| slsiaklkenvgKnRfkeilpydmsRvrLrt--dgskdsDYinAsfv--------dgykrrkayiatqgPlketveDfWRmvweykvstivmltnleeng KSKCVKYWPDE-YALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESiMDAGPVVVHCSAG |.||.||||.. .||| ..| ..|.. ||..|.||||| . . |..| |.|| .||.|.||.| ..|.....|...|. ....|.||.|. kekcakYWPekvdeeveygkfkvtlkeeekladyiirklklskekssegeadvtqfhfvaWpehevPkdatsllelikrvlraqkk-sgnkaitvvCsdg IGRTGTFIVIDILIDIIREKGvdcDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIE |||||||..|.... ... . .||| .... .|..| |.||..||| ||. |...||| vgrtGtfialdsvlerlkaee---eidvfevlktlrtkriglvqdaaqYvfihdalleyie |
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| Phosphatase | PTPN11.AA | Subfamily.N13.PD | 249-518 | 40 | 1e-74 | 242.8 | In-house | 4-254 (259) | Show / Hide |
Range on Protein: 249-518 Range on HMM: 4-254/259 Sequence Identity: 40% (110 aa) EEFETLQqqECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPnepvsdYINANIIMPEFetkcnnSKPKKSYIATQGCLQNTVNDFWRMVFQE |||..|. | | | . ..|...|||.||||.|.||.|.||| | | . ||||. | . . . .|||.|| | .||.|||.||.. eefkelr--elkpldtcevgkkkenkdknryrnvlPydetrvklgdegg------yinaslikvpv------gedeyeyiacqGPlPetvkdfwqmvweq NSRVIVMTTKEVERGKSKCVKYWPDEY--ALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGnTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQ ...||.| |.|.|.|| || .|||.. || .. ..|...| .....|.|..... | | | . .| .|||||||| ... |. ||.. |. kaeviamvtlekekgkvkchrywPerknkklkvsnrlevellkvqkldgfvvralavkdsesg-esrevahlnfvkwPdhgvPssaaelvqfvaevrllq EsimDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGvdcDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV ||||.||||||||||.|..|.||.....| . ..|| .... .| || |.|||. || |.| |. t---dagPivvhcsaGiGrsGvlitidvvlglierdk---efdvkeivrklreqrqgvvqtkdqyifvykai |
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| Phosphatase | PTPN11.AA | Subfamily.N5_RR.PD | 265-522 | 40 | 3.7e-74 | 240.9 | In-house | 15-264 (265) | Show / Hide |
Range on Protein: 265-522 Range on HMM: 15-264/265 Sequence Identity: 40% (105 aa) RKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIImpefetKCnNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGK ..| . ...|||||.||| ...||.|. ..... |.|||||.| | .. .| |.|||| |.||..|||||..||...||||.|| |. . qeelevfgsqtknryktilPnensrvllesessededssyinanyi------kG-ydeeskayvatqGPlpntiadfWrmiyqeevqvivmltklkeanr SKCVKYWPDEYAL---KEYGVMRVRNVKESAAHDYTLRELKLSKVGQgnTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESI-MDAGPVVVHCS .||..|.||. . ..|| . ..... .||..|.| |... . ||.| | . |||| .| |. .||...||....|. . ..||||||| qkcavyfPdaedyeiserygdveikveeiverndysvrklvlkyler--versvkhywytdWPdhksPddintlldlvleveesreeenaklaPvvvhcs AGIGRTGTFIVIDILIDIIREkgvDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI ||||||| || |.| . .|| . .|| |.. .| .| |||||. ||..|. |. .| aGiGrtGcfiaisiavrqlre---eivvdvlkivcnlrldrGGmvqtseqyelihralclyl |
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| Phosphatase | PTPN11.AA | Subfamily.N_Choan_1.PD | 246-522 | 36 | 5.1e-74 | 240.5 | In-house | 1-261 (262) | Show / Hide |
Range on Protein: 246-522 Range on HMM: 1-261/262 Sequence Identity: 36% (102 aa) GFWEEFETLQQQECKllYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDpNEPVSDYINANIImpefetkcNNSKPKKSYIATQGCLQNTVNDFWRMV || ||.|.|.. . . . . ...||..||||.|| .|.||| ... . .. .|||||| . . | .| ||||||. .....||.||. Gfieeyeklaeigvd--ntataskadenvlknrysnivayDatrvkvtpne-enkntDyinanfv--------pgykgekeyiatqgPvPaslvsfWqmv FQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLskVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHK ... ..||| |.|.| || || .||||| . ..| ..|....|.. . | |..|| ... .|.| | .. .|||||||... .|.| ..|.. . weqkvsaivmvtreieagklkChryWPdenselklgdvtvkslseeekktyierkfkl--eresgetreveqlaytaWPdhGvPattkellefrkavlka QESIMDaGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI .. . |.|.|||||.|||||.| .| |.. ..|| .|| ... .| .| |||| .||.|.| ||.... tkkktk-aplvihCsaGvGrtGtyialDrlvkaveekaea--ldvkavvaelrkernlmvqtlvqyefvykavldal |
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| Phosphatase | PTPN11.AA | Subfamily.RK.PD | 247-522 | 37 | 2e-73 | 238.3 | In-house | 2-266 (267) | Show / Hide |
Range on Protein: 247-522 Range on HMM: 2-266/267 Sequence Identity: 37% (103 aa) FWEEFETLQQQECKL-LYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNepVSDYINANIImpefetkcNNSKPKKSYIATQGCLQNTVNDFWRMV . ||||||.. .| . . .....|..|||...||..|...|.|. | . ||||||..| . | . .|.||| ||.||.||||.| lkeefetlnsvtpelqsedcdiakkdrnreknrsmdilaydrslvflisvdgd--ssdyinaali--------dsykrpaafivtqgPlqetvkdfWrlv FQENSRVIVMTTKE-VERGKSKCVKYWPDEYAlKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNT-ERTVWQYHFRTWPDH-GVPSDPGGVLDFLEEV ..||. ||| |. ||.|. ||.||||.. ..|| ..| |. .. |. | ....|. .|. |.| |..| .||.. .||..|... .|...| ydencasivmlteldvevgrvkClkyWPedte-vrygdikvelveaeldadlvvrifrveklargqeeirevrqfqflgWpeyrdvPvskrsllklirrv HHKQESiMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI | ..|..||||.|| ||.||||.|||....|...|| .|| .... .|.... ||.|| ||.|.| .. .. kksqee-eeeGrivvhClaGaGrsGtfiaidivlemieregv---vdvfnavktlrnrkvnmveteeqykfvydvileal |
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| Phosphatase | PTPN11.AA | Subfamily.N9.PD | 267-521 | 44 | 8.6e-73 | 236.6 | In-house | 20-273 (275) | Show / Hide |
Range on Protein: 267-521 Range on HMM: 20-273/275 Sequence Identity: 44% (114 aa) EGQRQENKNKNRYKNILPFDHTRVVLHDGDpNEPVSDYINANIimpefetkCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSK . . | .||||...| .|.|||.| | ... ||||||| .. | ||..||||| |..||.||||||.... .||||||. ||||. || asklranleknrytdvlcydetrvklakld-edeasdyinanf--------vdGykqkkafiatqGplkktvsdfwrmvweqevlvivmttrvvergrlk CVKYWP-DEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQgNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIM-----------DAGP .||| .| . .|.| ..|.||. . .||. | |....| . . .|.| . | .|||.||||. .||.||.| .|| .... |.|||||||||||| cgqywpleeessaefgdlsvsnveveveedykvrvleiknvkt-eesrkvthfqflswPdyGvPssaaslldvlekvrekqalavkelgdeskghlsgPP VVVHCSAGIGRTGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHY ||| .|| .. ..|.|. .|| .|....|.||. ..||. || | |.|| | ivvhcsaGiGrtGtfitldiclarleevgt---vdvvetvkllrtqrafsiqtpeqyefcylavley |
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| Phosphatase | PTPN11.AA | Subfamily.N3.PD | 251-518 | 39 | 5.2e-72 | 233.7 | In-house | 6-256 (261) | Show / Hide |
Range on Protein: 251-518 Range on HMM: 6-256/261 Sequence Identity: 39% (105 aa) FETLQQQECKLLYsrKEGQRQENKNKNRYKNILPFDHTRVVLHDGDpnepVsDYINANIIMPEFETKCNnskpKKSYIATQGCLQNTVNDFWRMVFQENS ||.| ... | .. .. || .||||..|||.|.||| |.... . |||||| . | .... . |||||| |..|..|||.||....| feelyrkkpglai--saarkpenlaknryrdilpydatrvklkese----t-dyinanyvnmeipstgl----vnryiatqGplaktakdfWqmvweqks RVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVgQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESim ..||| | ||||. || .|||.. |.| ..|| ||.. . | |||| |.. . . ||.. | . |||||||.|. .|.|.|.|...... tlivmlttlverGrvkChqyWPetedelefgefsvrcekedetksyvlrelvlkdk-etkeerkilqlqylaWpdhgvPddsadflefvervrklrsg-- DAGPVVVHCSAGIGRTGTFIVIDILIDIIREKgvdCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV . |||||||||||||| .|.... . .| .. .. ... ....| ||. .|||..||.|. |. keePvvvhCsaGigrtGvlilletalalieaa---epvypldivrtmrdqramlvqtvsqykfvCeai |
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| Phosphatase | PTPN11.AA | Subfamily.R_Ecdysozoa.PD | 247-522 | 36 | 6.4e-71 | 230.1 | In-house | 2-268 (269) | Show / Hide |
Range on Protein: 247-522 Range on HMM: 2-268/269 Sequence Identity: 36% (101 aa) FWEEFETLQQQEcKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDpNEPVSDYINANIImpefetkcNNSKPKKSYIATQGCLQNTVNDFWRMVF . ||.|.|... . | | ....||. ||||..| .||.|||.|. . ||||||. | . | ||..|| |. ...|..|||||. leeeyekLearl-eiskstkvsekkenalknryedikafDktrvkLkkin-gkedsdyinasfi--------kgykekkkfiaaqdPveatigDfWrmia QENSRVIVMTTKEVERGKSkCVKYWPDEyALKEYGVMRVRNVKESAAHDYTLRELKLSKVG--QGNTERTVWQYHFRTWP-DHGVPSDPGGVLDFLEEV- . .. .||| ... | . | ||||.| ..|| . |. |.|. ..||. |||..||.. . .|| ||.. .|. | || . |.|...|.| eqevtlivmlsnlteknrk-cakyWpie-devqygdilvklvseekhsdyiireldvskkkeesvedsrkvvqysytgWksDskvPevargllklieqvr -HHKQESIMD-AGPVVVHCSAGIGRTGTFIVIDILIDIIREKgvdCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI ..|... . .|.||||||| ||.|.|. .|.|.. ... .|. .|...||||. .|| .|| |.| |. .|. elyklnklsgsrsPivvhCsaGvgrsgifvaldlllqqlkae---dkvdifetvkkLrsqrnllvqsleqyvflyraladys |
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| Phosphatase | PTPN11.AA | Subfamily.N_Choan_2.PD | 271-523 | 36 | 5.5e-68 | 220.5 | In-house | 19-266 (266) | Show / Hide |
Range on Protein: 271-523 Range on HMM: 19-266/266 Sequence Identity: 36% (96 aa) QENKNKNRYKNILPFDHTRVVLHDGDpNEPVSDYINANIIMpefetkcNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKY ||. |||..||| .|||.|.. . ..... ||||| . .. ||.|||..| |..|...||||...|... |||||. .|.|..|| .||| arnkrlnRyndiLPsPatRvrleele-edsataYinAnyvr-------GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY WPDEYALK---EYGVMRVRNVKESAAHDYTLRELKLSKvgqGNTERTVWQYHFRTWPDHGVPSDPG------GVLDFLEEVHHKQESIMDAGPVVVHCSA | | ..| ..|....|. .. | |..|.| | ....|.. ... ||||||||.... .|. |..|.. .. . .|.|..||||||. Wpaepkekvkladgkikvlalseekeegyiltrlrlek---kgetrrlvHfwyntWpdhgvpreedsslstdqllkmlravrrvrkeldkaePllvHcsa GIGRTGTFIVIDILIDIIREKGvdcDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIE |||||.|.||| . .. |.. .|| . |. .| .| .||. ||...| ||..|.| GvgRtGtliaiDiavrlLeetk---kvdvlaiieelRkdRmalvqhpeqyellykavveyae |
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| Phosphatase | PTPN11.AA | Subfamily.N14.PD | 248-522 | 37 | 2.2e-66 | 215.3 | In-house | 3-274 (275) | Show / Hide |
Range on Protein: 248-522 Range on HMM: 3-274/275 Sequence Identity: 37% (106 aa) WEEFETLQQQECKLLYSrkEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNepVSDYINANIImpefetKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQ . |.| ..... . |.| .. .||..|||.|..||....|| | | ..|||| | | . ..|||..|| |..||.|||.||.. fteyeripkkredalls--taklpenaeknrfkdvlPyednrvelsptken--stgyinassi------kvsvggkersyivaqgPleltvqdfwqmvwe ENSRVIVMTTKEVERGKSKCVKYWPDE---YALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQgNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVH- .. ..||| |.| | ||.|..||.|.. |.| .| . . .. .. . ||| . . ||||| . |||||||.|. | |.|||||. qgvqlivmlteeeedgkeksfkylPkleskkktvefgkfkvttkfsedsdsvittglklkhlps-keertvwhlqytDWpdhgvPeDvkgflsfLeevqs --HKQESIMD-----AGPVVVHCSAGIGRTGTFIVIDILIDIIREkgvDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI .| .| .. ||.||||||.|||| |. |.|| . . . .||..|.....| || .||| |||.|.|.. .|. vrrktnsevesvkeskPPvlvhCsaGvGrtGvlilsdlliatleh---neeidikkvlarLrkqrmllvqtlaqykfvykvlikyl |
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| Phosphatase | PTPN11.AA | Subfamily.RG.PD | 248-521 | 34 | 2.6e-66 | 215.2 | In-house | 3-262 (264) | Show / Hide |
Range on Protein: 248-521 Range on HMM: 3-262/264 Sequence Identity: 34% (94 aa) WEEFETLQQQECKlLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDgDPNEPVSDYINANIIMPeFetkcnnsKPKKSYIATQGCLQNTVNDFWRMVFQ |.|| .|. . | . . ...|||.|||. ||......|| |.. |.. .|||||. |. . . .| ||.||| |..|..|||||.... eeqfeeiqklkpk-dieaesskkeenkeknReinivaversRvklsp-lpgkdgkDYinAsyidG-y-------rrskeyivtqgplketiedFWrmiWe ENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTE-RTVWQYHFRTWPDHGVPSDPggvLDFLEEVHHKQ |...||| |. .|.|. .. .|||.. |.. ..|. .... .||.|.. | . . . . |.| |||. .|||.|.|.|..| .|.... . .. hnaqiivmltdldekgrrdedvyWPkkdeplelealkvtllskeklskytvrdfvlkntkddkekervvrqyhytkWPdmgsPest---lfvlifvkkee ESIMD-AGPVVVHCSAGIGRTGTFIVIDILIDIIREKGvdcDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHY |||.|||.||| ||.||.|..| |. .... ..| ......|..| |.|.|| ||.||| |... aankeeaGPivvhdsaGvgragtyialdtllqqlekee---avnvyqvlklirakRpglvtteEqyvfiydallel |
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| Phosphatase | PTPN11.AA | Subfamily.N1.PD | 253-518 | 34 | 2.2e-65 | 212.3 | In-house | 8-263 (268) | Show / Hide |
Range on Protein: 253-518 Range on HMM: 8-263/268 Sequence Identity: 34% (93 aa) TLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPnepvsDYINANIImpEFEtkcnnsKPKKSYIATQGCLQNTVNDFWRMVFQENSRV ..... . .. .| ...||...|||... |.||.|..|...| |||||... |.| . |..|| ||| | .|.. ||.||...||. eidkeskekeletreaklpenrglnryrdvspydhsrikleradv-----dyinaslv--ele------eakrrYiLtqGPLphtadHFWqmvWeqnska IVMTTKEVERGKSKCVKYWPDEYAL----KEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTeRTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQES ..| | ||... ||..||| | | ..|. ..| . ...| |.| . . .| |.. ..|. |||| |||. | .|.|| .|.. vimLnkvvEknqikCaqywpqeeeeaellleetklkvkliseerksyflvrlleLedletqet-reilhfhyttwpdfgvpespaafLkfLfkvresgsL IMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV | ||.|.||||||||.||. ..| .. | ..| .|. | . .|..| |..|| | || |.|. ssdvgpavihCsagigrsgtlslvdtclveiektgdlnavdikkvLlelRkyRvGLiqtpdqLrFsyiai |
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| Phosphatase | PTPN11.AA | Subfamily.RN.PD | 263-520 | 39 | 1.2e-61 | 199.8 | In-house | 17-261 (264) | Show / Hide |
Range on Protein: 263-520 Range on HMM: 17-261/264 Sequence Identity: 39% (97 aa) YSRKEGQRQENKNKNRYKNILPFDHTRVVLHDgDPNEPVSDYINANIIMpefetkcNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVER ... .....| .|||.|..||.||.|| |.. . .. |||||| .|. .. . .|||||| | .|. |||.||... . |||.|. | | stkevakaeknvkknrskavlpydhsrvklke-easaeksdyinasail-------dhdprapayiatqgplsstiadfwqmvweqGvvvivnltrleee GKSKCVKYWPDEYAlKEYGVMRVRNVKESA-AHDYTLRELKLSKVgQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESimDAGPVVVHCSA ..| .||||| . . |.. |. | | ..|| .| . | . | . ||| |.|| .||..|||. . .|.| |. |.|||||.| ||||..|.| gvkqckrywpdeGs-evyhiyevhlvsehiwcddylvrsfylknl-qtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG--rscpivvhcsd GIGRTGTFIVIDILIDIIrEKGVDcDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQH |.... . ||| .||. |.. .| ||.|.|.|..|..|...|| . GaGrtGvyilidlvlerl-lkGvk-eidiaatlehlrdqrpglvktkdqfefaltavae |
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| Phosphatase | PTPN11.AA | Subfamily.RC.PD | 250-521 | 32 | 1.1e-56 | 183.7 | In-house | 5-286 (288) | Show / Hide |
Range on Protein: 250-521 Range on HMM: 5-286/288 Sequence Identity: 32% (95 aa) EFETLQQQECKllYSRKEGQRQENKNKNRYKNILPFDHTRVVL-----------HDGD-------PNEPVSDYINANIIMpefetkcNNSKPKKsYIATQ ||..| . | .. |.....|||.|||| ..||.|. || | || | | |.|||| |. ||.||||.|| efqrlpsvrsk--rtikiarkeenksknrysdvlpydynrvelkhelemskesehdsdessdddidseegskyinasfid-------sykkpek-yiaaq GCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWpdEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTeRTVWQYHFRTWPDHGVPSD |..||.|||||.|.. .|||| |. | . || .|| | . || . | .. . ||.|| |.| . . .. |.| |.. .|.....| .| GplketvddfwrmiferkvkvivmltelkeGdrekcaeyw--eeGkrayGdvevdlkdtdkssdyilrklelvnkkrkds-revtqiqytswsveqlpee PGGVLDFLEEVHHK--------QESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIRekgVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHY .|.... |..| . ..|..|||..| .|||.|| .. |.. . . .|| . .. .| .|..||..|.|| ..| .. .. pkellkliqvvkqklpqkrsseafknfkstpllvhcrdGsqrtGifiallallesle---aeekvdvfqvvkklrkarplmvsveeqyillydvlvet |
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| Phosphatase | PTPN11.AA | Subfamily.N23.PD | 262-521 | 33 | 1.8e-56 | 183.2 | In-house | 98-348 (350) | Show / Hide |
Range on Protein: 262-521 Range on HMM: 98-348/350 Sequence Identity: 33% (88 aa) LYSRKEGQRQENKNKNRyknilpfDHTRVVLHDGDPNEPVSDYINANIImpefeTKCNNSKPkkSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVE | ||.|..... |..||.|. . .||||| . . | ..||||| ...|..||| ||... |.|||| ||||| lqtegsGqqqgtpdsrh-------dpnrvklqqstqpgqqddyinatyl-----keltpmsP--pfiatqgPiastlaDFWlmvweqqssviVmltkeve RGKSKCVKYWPD-EYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQgNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQ-----ESI--MDAG ..| ||..||| | . . .| .|| .. .. . | |.|.. . .| |.| . |. ||...|||. |. .|.||.||... |...||||| gnklkcdqYwPidegetnlfgdlrvslkslrssegwiervlhlqhndv-stvrlvchlhtttWseiGvPksPedllaflgevetayaqqrktetegeggk PVVVHCSAGIGRTGTFIVIDILIDIIR-EKGVDcdiDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHY .|||||| |. | .. ..|. ..|. .. .| || |||........| || .. PiilhCsaGvgRtgtfcvvysaireltagngii---niprvvrrlrqqRkymvqkkvilkklyeavlea |
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| Phosphatase | PTPN11.AA | Subfamily.N_Nematode_1.PD | 250-521 | 34 | 8e-53 | 170.9 | In-house | 5-263 (265) | Show / Hide |
Range on Protein: 250-521 Range on HMM: 5-263/265 Sequence Identity: 34% (96 aa) EFETLQQQECKLlySRKEGQRQENKNKNRYKNILPFDHTRVVLHD-GDPnepvSDYINANIImpefetkCNNSKPkKSYIATQGCLQNTVNDFWRMVFQE ||..|.. . . . | . .....|||||.. |..||.|.. . | |||| || . . ..| | .| .|.|..|..||| ||.||. efralkkfndee--kvkafkeaqeadknrykdvgcldknrvklaeeplp----sdyihanyv-------gtptnp-krficaqaPldktiadfwymvlqe NSRVIVMTTKEVERGKSKCVKYWPDE----YALKEY----GVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLE ||| | .|.|| || .|.| . .|| | . .|| . .. .... .|. ||...|.| .|.. |||.|||. ..|..||.| kveaivmlckliekgkkkcaeyfpakegeklefkekgqkitvenslgvkkleedeevikvtvlevegaGektrkvthyqWtdWPdrGvPpadlaalelle EVHHKQesimdaGPVVVHCSAGIGRTGTFIVIDILIDIIREkGVDCDiDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHY .... ||.||||||||||||| ..|. ..| . | | .. |..|.. .|.||. .||.||| |.. . .| avrgsk------gPivvhCsaGiGrtGtivaieyildklle-gkqie-dmeklvkkireqrnysiqtdaqylfvhrvllny |
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| Phosphatase | PTPN11.AA | Subfamily.N20.PD | 266-518 | 38 | 5.2e-51 | 165.2 | In-house | 19-252 (257) | Show / Hide |
Range on Protein: 266-518 Range on HMM: 19-252/257 Sequence Identity: 38% (97 aa) KEGQRQENKNKNRYKNILPFDHTRVVLHDgdpnepVSDYINANIImpefetKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKS . |.. |..||||..|||.| ||| | |||||. | . | . |||||| | .|..|||.||...|| || | |.|.| | nsgnqpsnreknryrdilpydstrvplgk------skdyinasyi------rivncgeeyfyiatqgpllstiddfwqmvlennsnviamitreieggii KCVKYWPDEYA-LKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGnTERTVWQYHFRTWPDHGVPSDPGGvldFLEEVHHKQESIMdAGPVVVHCSAGIG || .||| | .|| . . . .| ... . | | ..| | .| ||||| |. |.. ... ..| ..||.|||||||||| kcyhywpislkkplelkhfrvflenyqilqyfiirmfqvvekstg-tshsvkqlqftkwpdhgtpasads---fikyiryarkshl-tgpmvvhcsagig RTGTFIVIDILIDIIREkgvDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV || |...|... | . .| ... . .| ||||||||. ||.| | | rtgvflcvdvvfcaivk---ncsfnimdivaqmreqrsgmvqtkeqyhfcydiv |
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| Phosphatase | PTPN11.AA | Subfamily.N_Nematode_4.PD | 271-521 | 32 | 2.8e-50 | 162.6 | In-house | 24-262 (264) | Show / Hide |
Range on Protein: 271-521 Range on HMM: 24-262/264 Sequence Identity: 32% (85 aa) QENKNKNRYKNILPFDHTRVVLHDGDPNepvSDYINANI-IMPefetkcnnskPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVK ..|..||||..|| |.|||||.. ||. ||| |. || | ||.||| |..|..||| ||..| |.|| . .| | || . eknsdknryadilcidetrvvlknrdpd---ndyihaswmrmP----------dkfryistqGPlketlsdfwhmvytekiavvvmlcdlieegvekcar YWPDEYAL-KEYGVMRVRNVKES--AAHDYTLRELKLSKVG---QGNTERTVW-QYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESimdaGPVVVHCSAG |.|.. ...| |.. |.. . | |. ||.... . ..|. | ... |.|. ||. |.... |..|... .|.|||||||. yypeksekvvkfGkyritlvekkeeviadvilnslkvtntekkkdapseplvvkhvqvdwwrdqvaPldaapviklykavkkkkke----kPivvhcsaG IGRTGTFIVIDILIDIIREKGvdcDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHY ||| |.. ||. |||.. .|.| . .. .|. | . ||.. |. |... . .. vGrtatlvGidyatirirens---eievldivrelramrlkavqshlqflfllvvliel |
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| Phosphatase | PTPN11.AA | PTPc_motif | 414-520 | 40 | 7.4e-46 | 159.59 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 414-520 Range on HMM: 1-92/92 Sequence Identity: 40% (45 aa) TVWQYHFRTWPDH-----GVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTE ||..||. .|||| |||. ..|.|...|.. |.|||||||.||||||..||.... .|. .|....|.|| |||||| TVHHYHYTNWPDHVEKDSGVPE--DSILEFIRHVRK---------PIVVHCSAGCGRTGTFCAIDMMMQQ---------VDIFQTVKEMRKQRPGMVQTE AQYRFIYMAVQH .||.|.|.... EQYIFCYRCILE |
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| Phosphatase | PTPN11.AA | Subfamily.N_Nematode_6.PD | 272-522 | 31 | 3.1e-44 | 142.8 | In-house | 23-252 (253) | Show / Hide |
Range on Protein: 272-522 Range on HMM: 23-252/253 Sequence Identity: 31% (78 aa) ENKNKNRYKNILPFDHTRVVLHDgDPNepvsDYINANIImpefeTKCNNskPkKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYW ..|..|||.|| .| .|..| | |.. || ||.. . . | . .| ||. |..|...||.|.. . |||. ||.|| |. .| .| kfkdrnrytniqCcdagrlklad-ded----fyihanlv-----kistk--p-rrlictqaplegtieefwkmilssgveyivmlcelvekgkeksaeyl PDEYALK-EYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQEsimdagPVVVHCSAGIGRTGTFI . . .. . . | .| . | .|. | | .|.. ||||||| . | .|. |.... |.|||||||.|||||...| sdkvGdarkitklctvikigrkdidkilvrslkrivkagdeevivkhihWanWPdhGvPdsflsalrllsvvkkdkk------PivvhCsaGvGrtGtla VIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI |... .| ..|.. . .| .| |||| || . . | |. liliilealrlpdf---qgvkdllvklreerfravqtevqylyalrcvleyl |
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| Phosphatase | PTPN11.AA | Subfamily.R_Nematode_2.PD | 271-518 | 31 | 2.2e-43 | 139.9 | In-house | 27-256 (261) | Show / Hide |
Range on Protein: 271-518 Range on HMM: 27-256/261 Sequence Identity: 31% (79 aa) QENKNKNRYKNILPFDHTRVVLHDGDPNEPvsdyINANIIMPefetkcnnSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKY .|.|.||... ..|.|. . | | || . .. .| .||||| |.||..||| || ||. ||| .. ||. |.|| .|.| ylpkdkhRypdvPCkpetavevivdgkrvp----ihanwvpt--------agnpkrfiatqgPlentsedfWamviqekvekivmlcqkvekekekceeY WPDEYALK-EYGVMRVRNVK--ESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQEsimdagPVVVHCSAGIGRTG | | . | .....|. . . .. . | || .. . . ||| | . |||.||| .. || |.. .. |.|||||||||||..|| fpletsqkldlgrfsiktvsaekilkdeiekrtlkvedstgkfatrtvthyqyeeWpdrgvPkshaelfeLlelvkksek------PivvhCsaGiGRtm TFIVIDILIDIIREkgvDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV .. | . . . | .| . .... .|..|. .||| |. .. .. afigteylarevea---dptieltealkelrehRwkgiqtesqlywltlga |
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| Phosphatase | PTPN11.AA | Subfamily.N_Nematode_5.PD | 250-522 | 28 | 6.2e-42 | 135.0 | In-house | 5-257 (258) | Show / Hide |
Range on Protein: 250-522 Range on HMM: 5-257/258 Sequence Identity: 28% (79 aa) EFETLQQQECKLLysrKEGQRQENKNKNRYKNILPFDHTRVvlhdgD-PNEPvSDYINANIIM-PEfetkcnnskPKKSYIATQGCLQNTVNDFWRMVFQ |||.|.. .. . . ..|..|||.|.. |.||| ..|. ..||||. |. .. .|..| |||..|..||||||.||. efeklaslkpnke---tckafeknlkknrskdvkilDetrV-----kltded-dsYinaskikldd---------lekkliltQlPlpdteedFWrmvyq ENSRVIVMTTKEVERGKSKCvKYWP-DEYALKEYGVMRVRNVKESAAHDYTlRELKLSKVGQGNTERTVWQ-YHFRTWPDHGVPSDPGGVLD-FLEEVHH .|. ... | . .. ...| . . ...| | ..| | ..| |... . .|. | .. . ||. ||... ||.. |. .|.|.. ekitsvvllvedeelketav-sffpletgdylnlgkmfinnrkvevkedek-keytvevlpegcsesvfakvyhlttWkkkkvPdkvkkvikraiekvls kqESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKgVDCDIDvpKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI .. . ||||....|.||.|||..... |. . .. . .|| ......|||| |.|.. .|| ..|.|| || --kkqgknapvvvvsdlGlgRagtflllsvaieqlnng-kepnid--eilkkirsqRpgavesliqyasvyaavldyi |
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| Phosphatase | PTPN11.AA | Subfamily.R_Nematode_3.PD | 265-520 | 24 | 1.4e-39 | 127.5 | In-house | 15-264 (267) | Show / Hide |
Range on Protein: 265-520 Range on HMM: 15-264/267 Sequence Identity: 24% (63 aa) RKEGQRQENKNKNRYKNILPFDHTRVVLHDgDPNEPVSDYINANIIMPEFETKCN-NSKPKKSYIATQgcLQNTVNDFWRMVFQENSRVIVMTTKEVE-- .. . ... ...|..... . .|||||.. . . .|.|.||... . ..| | | . ..|.. || |. ||.. ..||. . || knatslskkvsedrrvevpllektrvvLkg-ygkrfkddfihAnvvecpnglklIltqsPqkkdkekk--kkstieKfwwmieqekveqvvmlcdfveed -RGKSKCVKYWPDEYALK-EYGVMRV--RNVKESAAHDYTLRELKLsKVGqGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQEsimdagPVVV ... || .|.|.. . . . . | ..|. . .| |.|.. .. . | || .... |.....| .| .|. .. |.. . ||||| geeeekcseYypekvdgelkfegvsvkctdikkelsedvekrtlvv-tfe-kkkeftvthllykgWkelnapeepkealelikfvekskt------pvvV HCSAGIGRTGTFIVIDILIDIIREKGVdcDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQH ||.||.|..|. .|.. .. | .. ..|. . |. .|.|| | .|||.. |. . . . HCsdGisRsatlaaielgyqliikskg--kldllslikelrkqRagaiqtelelafvilgilk |
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| Phosphatase | PTPN11.AA | Subfamily.N_Nematode_egg.PD | 266-523 | 28 | 1.6e-29 | 94.6 | In-house | 19-257 (257) | Show / Hide |
Range on Protein: 266-523 Range on HMM: 19-257/257 Sequence Identity: 28% (73 aa) KEGQRQENKNKNRYKNILPFDHTRVVLhDGDPNEPVSDYINANIImpefetkcnNSKP-KKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERgk .. .....| | | . . .|| | . . |.| || . . || .| .| |.|||.|||||||||. . ||| | .| ttaasdnylekarskrvhckessrvkl-elrrGqylddfihanrv---------kGkpllnefilaqaplkntvedfwrmvfqekvqyivmltsakes-- SKCVKYWPD---EYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTV--WQYHFRTWPDHGVPsdpggvLDFLEEVhhKQEsimdAGPVVVHC .| ||| | . | .|. |.| . | .| || || . |. . ||. ..| | | | . .. . ||||.. | erceyywpkaeseslvtvpGslrienlkvdskadplfrvtklklvGgddeelflehwqgdvnylsdvysp------lrvlrkl--rnl----skpvvvqd SAGIGRTGTFIVIDI-LIDIIREkgVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIE . ...|.. |.| |....| | ......| .||.. .| |.| | ..|. ilGvskaatlvaieiallsllrG--pitkslvlravvflrlrrrlsvesvllylfvyrlvlffir |
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| Phosphatase | PTPN11.AA | Subfamily.N_Fungi_PTP1.PD | 273-391 | 34 | 3.3e-26 | 83.5 | In-house | 45-166 (343) | Show / Hide |
Range on Protein: 273-391 Range on HMM: 45-166/343 Sequence Identity: 34% (42 aa) NKNKNRYKNILPFDHTRVVLHDGD-------PNEPVSDYINANIIM-PEFETKCNNSKpkkSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGK |||||||||..|.|| |. . .|||||| . . | . | . |||||. |..||.||....... .||.. |..|| . || lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdf---kYiatqaPlpstvddfykvillnkvkvilsltsdvelnl SKCVKYWPDEyALKEYGVmRVRNVKES .||.. . ... | .. . .|. ekcyrYWqeg-sydditv-klaskwen |
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| Phosphatase | PTPN11.AA | Subfamily.N_Nematode_eak.PD | 261-429 | 31 | 6.8e-21 | 66.3 | In-house | 14-170 (281) | Show / Hide |
Range on Protein: 261-429 Range on HMM: 14-170/281 Sequence Identity: 31% (53 aa) LLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEpvSDYINANIImpEFetkcnnSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV | | ....| |. |.|| .|.|.|. | | |. |||| .. || |. . || | .. | ||.||....| ||. ..|| rllsirvtarleavnrnrvvkivpqdrylvrltssqlnr--dGyinasla--ef------sevGrkyiltGiasedkvfafwqmvleqkspaivqlledv ERGKSKCVKYWPDEYALKEYGVMRVRnVKESAAHDYTLrELKLSKVGQGNTERTVWQYHFRTWPDHGVP . | ||.||. .||.. | || | . | | .| .. .|| | |.. |. .| eekleksdkyfpdktevlkyGildve-rkeyavkrnil-etrllilrkGnethrvlhykvfGwtettlp |
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| Phosphatase | PTPN11.AA | Subfamily.N_Fungi_PTP1.PD | 413-521 | 27 | 9.2e-19 | 59.1 | In-house | 213-341 (343) | Show / Hide |
Range on Protein: 413-521 Range on HMM: 213-341/343 Sequence Identity: 27% (35 aa) RTVWQYHFRTWPDHGVPSDPGGVLDFLE--------EVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILID------IIREKGVDCDID------VPK .|.| ... |.| .. .| .| || . .. . |..||||||.|||||.. .| |. ..... | . .. yevyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisi TIQMVRSQRSGMVQTEAQYRFIYMAVQHY . .|.|| |||. |. ||| |...| ivnelrkqrismvqnldqfifiYeallfy |
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| Phosphatase | PTPN11.AA | Family.DSP.PD | 336-548 | 18 | 3e-14 | 44.6 | In-house | 94-263 (387) | Show / Hide |
Range on Protein: 336-548 Range on HMM: 94-263/387 Sequence Identity: 18% (41 aa) NTVNDFWRMVFQENSRVIVmttkEVERGKSKCVKYwpdEYALKEYGVMRVRNVKesaahdytlreL------KlskvgqgnteRTVWQYHFRTWPDHGVP .| ..| |. ...|... .. |. . .| . .|||.|| .. |.. | . .|. ..||..| dtydhfervengkpseilp----hlylgsllaakn---lewlkelgvtkivnlt-----------ddkpqftk----------elgikylripidDhnap SDPGgVldFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDiirekgvdCDIDVPKTIQMVRSQRSGMVQTEAQyrfiymavqhYIETLQRRI . . | . . .|. .. | |.||| ||.||.|| |.. .. .. ......|||.|.|... . . ... |.. plen-l--fekaidfieegndskgvVlVHCkaGkgRsgtliiaYlmks--------egltleealdwvrskRpgvitpnqg----------flkqlkdle EEEQKSKRKGHEYTNIKYS .| | ... |. ...| keklkvssevmelrfviss |
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| Phosphatase | PTPN11.AA | Subfamily.PTPDC1.PD | 377-514 | 27 | 3.4e-11 | 34.5 | In-house | 94-220 (229) | Show / Hide |
Range on Protein: 377-514 Range on HMM: 94-220/229 Sequence Identity: 27% (39 aa) LKEYGVMRVRNVKESAAHDYTLRELKLSK---VGQGNTERTVWQYHFrTWPDHGVPSdPGGVLDFleeVHHKQESImDAGPVVVHCSAGIGRTGTFIVId .|| |. | |..|. | . |. | .. . | | ...|.||.| .|| | . .. | . ||| |||||| | . fkesGikavinLqeagehahCGagleesGfsYdpeelmrqgiyfynf-glkDygvas-leriLdi---vkvvdfal-eegkiavHCHAGlGRtGvliac- ILIdiiREKgvdcDIDVPKTIQMVRSQRSGMVQTEAQYRFI |. | ... . |..|||.|. .|| | ... ylv---yak----rltaeeaiklvrskrpksiqtreqvelv |
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| Phosphatase | PTPN11.AA | Subfamily.N_Nematode_eak.PD | 456-522 | 34 | 3.7e-11 | 34.3 | In-house | 215-280 (281) | Show / Hide |
Range on Protein: 456-522 Range on HMM: 215-280/281 Sequence Identity: 34% (23 aa) VVHCSAGIGRTGTFIVIDILIDIIREKGVDcDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI .. .. | |.|.|.|||.|| .| .| . | . | |.|.| | .. |. ||| .| .|. iiqsarGsaraGvfvvidllirlidnkkkn-lysvedlilkvkskrihsvlvalqhsfiyeivldyl |
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| Phosphatase | PTPN11.AA | Subfamily.DSP23.PD | 446-514 | 30 | 2.9e-08 | 25.4 | In-house | 60-120 (128) | Show / Hide |
Range on Protein: 446-514 Range on HMM: 60-120/128 Sequence Identity: 30% (21 aa) QESIMDAGPVVVHCSAGIGRTGTFIVIdiliDIIREKGVDCDidvpKTIQMVRSQRSGMVQTEAQYRFI .|. ..| ||| |.|||||.. ...|.|. | ..| || .| | ..| | . . eeaekkeeavgvhcalGlGrtGtllac----ylvkeeglaad----daiaevrkrrkGsietveqekav |
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| Phosphatase | PTPN11.AA | Subfamily.CDC14.PD | 449-509 | 30 | 4.9e-07 | 21.2 | In-house | 197-247 (258) | Show / Hide |
Range on Protein: 449-509 Range on HMM: 197-247/258 Sequence Identity: 30% (18 aa) ImdAGPVVVHCSAGIGRTGTFIVIDILIdiirEKGvdcdIDVPKTIQMVRSQRSGMVQTEA . | ..||| ||.|||||.| ... . . . . || .| | |.| . a--eGaiavhCkaGLGrtgtligcylik----hyr----ftaaetiawlriarPGsvigpq |
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| Phosphatase | PTPN11.AA | Subfamily.PTEN.PD | 454-515 | 27 | 1.7e-06 | 19.1 | In-house | 96-153 (305) | Show / Hide |
Range on Protein: 454-515 Range on HMM: 96-153/305 Sequence Identity: 27% (17 aa) PVVVHCSAGIGRTGTFIVIDILIDIIREKGVdcdiDVPKTIQMVRSQRSGMVQTEAQYRFIY |.||| || ||||. |. .| |.... . . . .|.. . | | |... VvavHCkaGkGRtGvmicayLlksgikksad----ealaiydekRtkdkkGVtiPSQrRYvq |
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| Phosphatase | PTPN11.AA | Subfamily.DSP12.PD | 435-472 | 34 | 8.4e-06 | 17.4 | In-house | 63-101 (143) | Show / Hide |
Range on Protein: 435-472 Range on HMM: 63-101/143 Sequence Identity: 34% (13 aa) VLDFLEEVH-HKQESIMDAGPVVVHCSAGIGRTGTFIVI .|..|.|. . .|.. | |.||| ||. | |... lLshldeavrFieeglekegavlvHClagvSRSvtiviA |
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| Phosphatase | PTPN11.AA | Subfamily.DSP19.PD | 436-501 | 33 | 8.7e-06 | 17.1 | In-house | 69-120 (139) | Show / Hide |
Range on Protein: 436-501 Range on HMM: 69-120/139 Sequence Identity: 33% (22 aa) LDFLEEVHHKQesimdaGPVVVHCSAGIGRTGTfIVIDILIDiirekgvDCDIDVPKTIQMVRSQR |||.||...|. | |.|||.||. |. . .|| |. | .... |....||..| ldFieearskd------grvlvHCnAGvSRsas-vviaylmk-------deelslekalekvrear |
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