Gene PTPN6
PTPN6
Species: Human
Alias: HCP, SHP1, PTP-1C, SHP-1L, HPTP1C, HCPH, SHP-1, SH-PTP1, PTPN6
External Links:
COSMIC
,
Entrez Gene
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of PTPN6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| SH2 | PTPN6.AA | SH2 | 2-85 | 36 | 2.3e-29 | 104.8 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 2-85 Range on HMM: 1-87/87 Sequence Identity: 36% (32 aa) VRWFHRDLSGLDAETLLKGR-GVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSG-DFYDLYG--GEKFATLTELVEYYTQQQGV |.| ..|. .|| |||.. . .|.|| |.|..| ||..||||....| |.||. .. . | . . ..|| .| |||..|.. .. QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG |
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| SH2 | PTPN6.AA | SH2 | 4-79 | 40 | 9.1e-40 | 118.58 | Pfam | 1-81 (81) | Show / Hide |
Range on Protein: 4-79 Range on HMM: 1-81/81 Sequence Identity: 40% (33 aa) WFHRDLSGLDAETLLKG-RGVHGSFLARPSRKNQGDFSLSVRVGD---QVTHIRIQNSGDF-YDLYGGEKFATLTELVEYY |.|...|. .|| ||. .. .|.|| |.|. ..||..|||| .. .|.|.|||. .. | ..|..||..| ||||.| WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY |
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| SH2 | PTPN6.AA | SH2 | 108-200 | 32 | 8.5e-32 | 112.87 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 108-200 Range on HMM: 1-87/87 Sequence Identity: 32% (32 aa) ERWYHGHMSGGQAETLLQAK-GEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEG-GRYTVGG--LETFDSLTDLVEHFKKTGIE . ||||..|. .|| ||.. ... .||||.| |.|||.|||| .. .| |... ... |.| ... ..|.|| .||.|.... . QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK---------GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG |
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| SH2 | PTPN6.AA | SH2 | 110-194 | 42 | 8.9e-38 | 112.74 | Pfam | 1-81 (81) | Show / Hide |
Range on Protein: 110-194 Range on HMM: 1-81/81 Sequence Identity: 42% (37 aa) WYHGHMSGGQAETLLQA-KGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGR-YTVGGLETFDSLTDLVEHF ||||..|. .|| ||.. ....||||||| |.|||..|||. | | . ||.|......... | ..| ..|.|| .||||. WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP------GDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY |
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| Phosphatase | PTPN6.AA | Family.DSP.PD | 238-508 | 15 | 5.8e-15 | 47.2 | In-house | 47-239 (387) | Show / Hide |
Range on Protein: 238-508 Range on HMM: 47-239/387 Sequence Identity: 15% (42 aa) DTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINanyikNQLLGPDENAKTyiaSQGCLEATVNDFWQ ||.| | .. ... .||.| . .. .|. ... || . | | ..| . . ||. ..|| .. |. |.. dtvkpkfapfrdasyapvlaklhvryvisgakqaelngfidvhtfdldtydhfervengkpseilp-----hlylgsllaakn---lewlkelgvtkivn MAwqensrvivmttrevekgrnkcvpywpevgmqraygpysvtnCGeHDTTEYklrtlqvspldngdliREIWHYQYLSWPDHGVPSEPGGVLSFLDQIN .. .. .. .. .. .| ....||..|. ....| |.. lt------------------------------------------dd-kpqftk----------------elgikylripidDhnapplenlfekaidfie QRQEslpHAGPIIVHCSAGIGRTGTIIVIdMLMENistkgldCDIDIQKTIQMVRAQRSGMVQTEAQYKFI .. . | . ||| ||.||.||.|.. ||.. .. ......|| .|.|... . ... egnd---skgvVlVHCkaGkgRsgtliia-Ylmks-------egltleealdwvrskRpgvitpnqgflkq |
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| Phosphatase | PTPN6.AA | PTPc | 243-517 | 37 | 4.1e-131 | 442.78 | SMART | 1-308 (308) | Show / Hide |
Range on Protein: 243-517 Range on HMM: 1-308/308 Sequence Identity: 37% (120 aa) GFWEEFESLQKQEVKNLH-------QRLEGQRPENK--GKNRYK-NILPFDHSRVILQGRD---SNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLE |||||||.||......|. . ....|||. ||||| .|...||.||.|. .. .. .||||||||||. .. |.||. ||.|. GFWEEFERLQRMTPWDLMSNYDPCCSCTCACWPENREMDKNRYKCDIPCYDHTRVKLKPPPGESHCYEGSDYINANYIDGY-----WRPKRYICTQGPLP ATVNDFWQMAWQENSRVIVMTTREVEK--------GRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTT-EYKLRTLQVSPLDNG-------DLIREIWHYQ |..|||.| ||.....||| ....|| ||.|| |||. || ..||.. |. . .|..||..|.. ... . |...||. HTIEDFWRMVWQQKCHIIVMLCNCMEKCTENRDQNGREKCHQYWPDE--PMTYGHITVTCKSEEKCPDDYTMRTFEVTNTGCNCKYSMACSETRTVTHYH YLSWPDHGVPSEPGGVLSFLDQINQRQESLPH-----------------AGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRS | .|||||||. | ..|.|. |....|...|. .|||.||||||.|||||...||.... | . .|| ....|.| || YTNWPDHGVPESPDSFLDFIRQVRHWQSHSPNMYMNMVSSNSKYHHTCPTGPIVVHCSAGCGRTGTFCAIDIMCQQIEN------VDIFQIVKMMRNQRP GMVQTEAQYKFIYVAIAQFIE ||||||.||.|.| .|...|. GMVQTEEQYIFCYRCILEYIK |
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| Phosphatase | PTPN6.AA | Subfamily.N6.PD | 240-517 | 57 | 2.9e-129 | 422.2 | In-house | 10-295 (295) | Show / Hide |
Range on Protein: 240-517 Range on HMM: 10-295/295 Sequence Identity: 57% (164 aa) AKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYI--------KNQLLGPDENAKTYIASQGCLEAT |||||||.|||||...|..| ||...||| ||||||||||||.||||. .....||||||||||| ... . .|. |.|||.||||..||.| qtlgfweefeelqkqeseklysrkegekienkeknryknilPfDhtrvilkdgepsvpgsdYiNanyirlpkaskssgenveseehqkryiatqgcLkdt VNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLS ||.|.||||||||||||.|||.|.|||. |||. . ....| ..||.. |. |..|.||...|| |. . |||..|.. .|||||||..|| ||.||. vsdFWrmvwqensrvivmttkevergknkCarYWPdeetkketGvitvtsisEkstadYtlRefsvshkdkdkeareifqyhfkaWPdhgvpkdpgvvln FLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIE ..|..||.| .||||.||||||||||||.||||.... |...|||.||||.|.|..||.||||.|||||||||.|.|....|| fledvnkkqeelekagpivvhcsaGiGrtGtfividivlkiieqsgldvdidisksikdvrsqrsglvqteaqykfvykavqfyie |
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| Phosphatase | PTPN6.AA | Y_phosphatase | 270-514 | 42 | 4.4e-115 | 393.44 | Pfam | 1-243 (243) | Show / Hide |
Range on Protein: 270-514 Range on HMM: 1-243/243 Sequence Identity: 42% (108 aa) NKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGR-NK-CVPYWPE || |||||.|...||.||.||. . ..|||||||||. |. | |.||. || .. |..|||.| ||.....||| ....|.|| .| | .|||. NKEKNRYKDIPCYDHTRVKLQPI-PGDEDSDYINANYIDG----PYWNPKAYICTQGPMPHTIEDFWRMVWQQKCTCIVMLCNCMEMGRDEKTCHQYWPD --VGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDN-GDLIREIWHYQYLSWPDHGVPSE-PGGVLSFLDQINQRQESLPHAG--PIIVHCSAGIGRTG .| ||...||. |. ...| .||..|. .. .. |...||.|..|||||||. | ..|.|..|... |. |..| ||.||||||.|||| NKEGQPMTYGDFQVTCVSEEHCPDYTVRTFEVTN-GDQKQETRTVTHYHYTNWPDHGVPESQPKSMLDFIRQVRKWQP-NPDHGCPPIVVHCSAGCGRTG TIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ | ..||.... . ..| || ......|.|| ||||||.||.|.| .|.. TFCAIDIMCQQMEHEGTV---DIFQIVKHMRNQRPGMVQTEEQYIFCYQCILE |
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| Phosphatase | PTPN6.AA | Subfamily.RB.PD | 244-516 | 38 | 4.3e-81 | 263.8 | In-house | 2-260 (261) | Show / Hide |
Range on Protein: 244-516 Range on HMM: 2-260/261 Sequence Identity: 38% (104 aa) FWEEFESLQKQEVKnlHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNiPGSDYINANYIKNQllgpdENAKTYIASQGCLEATVNDFWQMAWQEN | ||.|.|.| . . .. . ....|. |||..||||.||||| |. ... ...||||||||.. .. . |||.|| |. ||.|||.| |... fseeyeelkkvgkd--qavkaaeeavnraknrftnilpydhsrvkLaalkde-sdtdyinanyipgy-----nspreyiatqGPlpetvddfWrmvwekk SRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPldnGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESL |..||| |. ||||..|| |||. . .|| .|| |....|. .|..... |. .|.. .|...||||||||... .|.|. ..... |. ssiivmltqlvEkgkekceeYWPadeepvlyGdikvtllaekeldewvirefkiek---gkekrkvrqyhftsWpdhgvPektktlldfvrtvreaiekk PHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGldcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI ....||.||||||.||||| | .|.|...|... .|. .. .| .| .||||.|| ||. ...... askkPivvHCsaGvGRtGtfialdrllqaieend---yvdvfgvvaelReeRnllvqtekqyifiheclldll |
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| Phosphatase | PTPN6.AA | Subfamily.N12.PD | 246-516 | 38 | 6.8e-81 | 263.0 | In-house | 4-269 (270) | Show / Hide |
Range on Protein: 246-516 Range on HMM: 4-269/270 Sequence Identity: 38% (108 aa) EEFESLQKQ----EVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNiPGSDYINANYIKNQllgpdENAKTYIASQGCLEATVNDFWQMAWQ .||..|.|. .. ... .|...||. |||||.|||.|.|||.|. ... .||||||||.||. |. ..|||.|| | .|..|||.| |. kefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieee-egsdyinanfikgv-----egkleyiaaqgPLpktlddfWrmiwe ENSRVIVMTTREVEKGRNKCVPYWPEVGMQRA-YGPYSVTNCGEHDTT-EYKLRTLQVSpldNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQR | ...|| |||| |..|| |||| | .. .|...||. |. .. .. .|||.| . . |.. ..| .||||||||.. .|......... knveivvmaCrevelgkkkCeryWpeegeeelefgefevtleeekavdddflirtLkve---aqkesrkvyqfhytaWPDhgvPssaksllelielvrel QEslPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI || .. |..||||||.|||||||.||. | . .. .. ..|. . .. .| ||. .|||. ||...| |.|... qe--sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv |
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| Phosphatase | PTPN6.AA | Subfamily.R_Anemone_2.PD | 244-516 | 41 | 6.8e-79 | 256.8 | In-house | 2-261 (262) | Show / Hide |
Range on Protein: 244-516 Range on HMM: 2-261/262 Sequence Identity: 41% (112 aa) FWEEFESLQKQEVKNLHQRlEGQRPENKGKNRYKNILPFDHSRVILQGRDSNiPGSDYINANYIKNQllgpdENAKTYIASQGCLEATVNDFWQMAWQEN . ||.| |...| .... . . ..| || |||| |||..|..|| || .... .|||||||||| .. |.|||.|. ||..|||.| |. ||. lseeyerlsrseetsvtlk-salepvnkaknryanilaydktrvklqmlege-egsdyinanyidGy-----rrkkayiatqaPlpetiedfWrmvWeqn SRVIVMTTREVEKGRNKCVPYWPEVGMqRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLiREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESl |||| |.|.|.|. |. |||. | |.|| |. | ....| ||...|. .. . |.. ..| ||||.|||......|... |... |.. . savivmltqeeergkakvhryWPskgs-rsygklvvelkeevelsdyvlrsfkvkrteeeee-rqvrqfhytsWpdegvpesgaslldlvrqvekaqqe- PHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLdcdIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI ||||.||||||.||||. |..|.|.| | .| .|. .|....| ||. ||||. ||.||| .. ... sgagpivvhcsaGvGrtGvfiavdillerikaeal---vdvfqtvkqlreqrnlmvqtkdqyefiydvlleal |
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| Phosphatase | PTPN6.AA | Subfamily.R_Anemone_1.PD | 246-515 | 37 | 8.9e-76 | 246.6 | In-house | 4-256 (258) | Show / Hide |
Range on Protein: 246-515 Range on HMM: 4-256/258 Sequence Identity: 37% (101 aa) EEFESLQKQEVKnlhQRLEGQRPENKGKNRYKNILPFDHSRVILQgRDSNIPGSDYINANYIKNQLlgpdENaKTYIASQGCLEATVNDFWQMAWQENSR .||. |.... . . ....||| ||||..|...|||||.|. . || . |||||| |.. . . ...||.|..||.||.|||.| |||.. aefqrlkeikee---ekevarkaenkkknryadivaldhsRvvLe-klsndeesdYinasylrasd----kt-rafiatqapleetvedFWrmvwqekig VIVMTTREVEKGRNKCVPYWPEvgMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGdLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRqeSLPH |||| | .|. .|| |||. ...|| ..|. . . . ..| .||| .| .. ||. .|....|||.|||.. ||......... ||.. viVmLtnliegekkkchqYwPd--stekygelrvslrkkevfadyiirtlvlskkket-eerevvqyhftvWpdkgvPqyatavLglrrkvqks--slag AGPIIVHCSAGIGRTGTIIVIDMLMENISTKGldcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF | |..||||||.||||. .||| ..| . .. .|| ......| .| ||||. || ||. |. . arpvvvhCsaGvgRtGaflvidamleqakkek---vvDifnyvkairedrphmvqtkeqyvfihlavlea |
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| Phosphatase | PTPN6.AA | Subfamily.N13.PD | 246-514 | 39 | 3.9e-74 | 241.1 | In-house | 4-256 (259) | Show / Hide |
Range on Protein: 246-514 Range on HMM: 4-256/259 Sequence Identity: 39% (107 aa) EEFESLqkQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSnipgsdYINANYIKNQLlgpDENAKTYIASQGCLEATVNDFWQMAWQENSR |||. | .|.| | . .|.. ||| ||||.|.||.|..||.|.. . ||||..|| .. .|. .|||.|| | ||.||||||. ...| eefkel--relkpldtcevgkkkenkdknryrnvlPydetrvklgdegg------yinaslikvpv---gedeyeyiacqGPlPetvkdfwqmvweqkae VIVMTTREVEKGRNKCVPYWPEVGMQR--AYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDlIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQEsl |.| | |.|||. || |||| .. ... . |.. . . ....|.|.|. .. |. ||. | .. .||||||||.. .. |. .... |. viamvtlekekgkvkchrywPerknkklkvsnrlevellkvqkldgfvvralavkdsesge-srevahlnfvkwPdhgvPssaaelvqfvaevrllqt-- pHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGldcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ .||||.|||||||||.|..|.||.... |. . ..|...... .| || |.|||. || |.| || . -dagPivvhcsaGiGrsGvlitidvvlglierdk---efdvkeivrklreqrqgvvqtkdqyifvykaile |
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| Phosphatase | PTPN6.AA | Subfamily.R_Sponge_2.PD | 260-517 | 35 | 4.6e-73 | 237.6 | In-house | 15-262 (262) | Show / Hide |
Range on Protein: 260-517 Range on HMM: 15-262/262 Sequence Identity: 35% (91 aa) HQRLEGQRPENKGKNRYKNILPFDHSRVILQGrdSNIPGSDYINANYIKNQllgpdENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRN . ... .||.||||.|.|||.|.||| |. .. ..||||||... .. |.|||.|| |..||.||| | | ...||| | .|.|..|| fslsiaklkenvgKnRfkeilpydmsRvrLrt--dgskdsDYinAsfvdgy-----krrkayiatqgPlketveDfWRmvweykvstivmltnleengke KCVPYWPEV-GMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESlPHAGPIIVHCSAGIG . |||| . . || . || |. ...|..|.|..| .. . ... ......||.|.||.. . .|........ |. ..|.|.||.|.||| kcakYWPekvdeeveygkfkvtlkeeekladyiirklklskekssegeadvtqfhfvaWpehevPkdatsllelikrvlraqkk-sgnkaitvvCsdgvg RTGTIIVIDMLMENISTKGldcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIE || |..|...| . . . .||. .... .| .| |.||..|||.||. |....|| rtGtfialdsvlerlkaee---eidvfevlktlrtkriglvqdaaqYvfihdalleyie |
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| Phosphatase | PTPN6.AA | Subfamily.N5_RR.PD | 266-515 | 37 | 8.9e-73 | 236.6 | In-house | 19-263 (265) | Show / Hide |
Range on Protein: 266-515 Range on HMM: 19-263/265 Sequence Identity: 37% (94 aa) QRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKnqllGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYW . . .. |||||.||| ..|||.|. ..|. . |.|||||||| |.||. |.|.| || | |..|||.| .||...||||.|. |.|.||. |.| evfgsqtknryktilPnensrvllesessededssyinanyik----GydeeskayvatqGPlpntiadfWrmiyqeevqvivmltklkeanrqkcavyf PEVG---MQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNgdLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQ-RQESLPHAGPIIVHCSAGIGRTG . .. || .... . .. .|..|.| .. | . . |.. || | .|||| .| .. .|........ |.|....|..||||||||||| | Pdaedyeiserygdveikveeiverndysvrklvlkyler--versvkhywytdWPdhksPddintlldlvleveesreeenaklaPvvvhcsaGiGrtG TIIVIDMLMENISTkglDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF |.. . .. . .|. |.. .| .| |||||. ||..|. |.... cfiaisiavrqlre---eivvdvlkivcnlrldrGGmvqtseqyelihralcly |
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| Phosphatase | PTPN6.AA | Subfamily.RA.PD | 244-516 | 37 | 7e-72 | 233.7 | In-house | 2-265 (266) | Show / Hide |
Range on Protein: 244-516 Range on HMM: 2-265/266 Sequence Identity: 37% (104 aa) FWEEFESLQKQEVKNLHQRLeGQRPENKGKNRYKNILPFDHSRVILQGRDsNIPGSDYINANYIKnqllGPdENAKTYIASQGCLEATVNDFWQMAWQEN . |||..| . .... . |. ....||| |||. .|||.|.|||||. .. .. |||||| .|. | .. ...||.|| .| ||.|||.| |. . leeefkkltsvkiqkeklrt-ankeenkkknrvvqilpydfsrvilsvke-Geeesdyinasfid----Gy-rekdkfiaaqGpkeetvedfwrmiweqk SRVIVMTTREVEKGRNKCVPYWPEVGMQrAYGPYSVTNCGEHDTTEYKLRTLQVSPLD---NGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQ | ||| | |....|| |||. |. .|| |. | . .| .| . | | . . | . . . |||. |||.|. |.|..| .... | sativmltelkerkeekcaqywpdeGlv-tyGeirvevkdetvledytvrdflvtqlpdatrekksrlvrqfhftswpevGvpaegkGmlkllkkvkklq ESlpHAG-PIIVHCSAGIGRTGTIIVIDMLMENISTKGLdcdIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI . .|. ||.||||||.||||| ||.| ..| . .... .|. .... .|.||. ||||. ||.||| .. ..| qq--sanhpivvhcsaGvGrtGtfivldavlervkaerk---ldvfeavkrlrlqrpqmvqtleqyefiykvlleyi |
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| Phosphatase | PTPN6.AA | Subfamily.N9.PD | 243-515 | 36 | 3.2e-71 | 231.7 | In-house | 1-273 (275) | Show / Hide |
Range on Protein: 243-515 Range on HMM: 1-273/275 Sequence Identity: 36% (103 aa) GFWEEFESLQKQEVKNLHQRleGQRPENKGKNRYKNILPFDHSRVILQGRDSNiPGSDYINANYIKNQllgpdENAKTYIASQGCLEATVNDFWQMAWQE | .|........|. .. . . | ||||...| .|..|| |. .| . . |||||||... .. |..||.|| |. ||.|||.| |.. GlskeyadirnepveGtfla--sklranleknrytdvlcydetrvklaklded-easdyinanfvdGy-----kqkkafiatqGplkktvsdfwrmvweq NSRVIVMTTREVEKGRNKCVPYWP-EVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDlIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQE . .||||||| ||.|| || ||| | . . .| .||.| . . . .|| |.|... .... .|.. |.|.|||||.||||. .| .|... ..| evlvivmttrvvergrlkcgqywpleeessaefgdlsvsnveveveedykvrvleiknvktee-srkvthfqflswPdyGvPssaaslldvlekvrekqa SL-----------PHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGldcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF .. .. ||.|||||||||||| | .|. .... ..| .|...|....|.||. ..||. ||.| |.|... lavkelgdeskghlsgPPivvhcsaGiGrtGtfitldiclarleevg---tvdvvetvkllrtqrafsiqtpeqyefcylavley |
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| Phosphatase | PTPN6.AA | Subfamily.N_Choan_1.PD | 243-516 | 35 | 3.7e-71 | 231.3 | In-house | 1-261 (262) | Show / Hide |
Range on Protein: 243-516 Range on HMM: 1-261/262 Sequence Identity: 35% (96 aa) GFWEEFESLQKQEVKNLHQrlEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIpGSDYINANYIKNQllgpdENAKTYIASQGCLEATVNDFWQMAWQE || ||.|.|.. .|.| . ...||. ||||.|| .|..|| .. ..| .||||||... .. | |||.|| .|....|||| |... Gfieeyeklaeigvdntat--askadenvlknrysnivayDatrvkvtpneenk-ntDyinanfvpgy-----kgekeyiatqgPvPaslvsfWqmvweq NSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVsPLDNGDlIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQES ..||| |||.|.|. || |||. . .| . |.. |.....| |.... ..|. ||. . .|..|||||||... .|.| ..... ... kvsaivmvtreieagklkChryWPdenselklgdvtvkslseeekktyierkfkl-eresge-treveqlaytaWPdhGvPattkellefrkavlkatkk LPHaGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLdcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI . |...|||||.||||| | .| |......| .|.. ... .| .| |||| .||.|.| |. . . ktk-aplvihCsaGvGrtGtyialDrlvkaveekae--aldvkavvaelrkernlmvqtlvqyefvykavldal |
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| Phosphatase | PTPN6.AA | Subfamily.N3.PD | 264-514 | 39 | 1.7e-70 | 228.9 | In-house | 20-258 (261) | Show / Hide |
Range on Protein: 264-514 Range on HMM: 20-258/261 Sequence Identity: 39% (98 aa) EGQRPENKGKNRYKNILPFDHSRVILQGRDsnIpgsDYINANYIKNQLLGPdENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVP . ..||| ||||..|||.|. ||.|. . |||||||.. .. . . . |||.|| |. |..||||| |...|..||| | ||.|| || aarkpenlaknryrdilpydatrvklkese--t---dyinanyvnmeipst-glvnryiatqGplaktakdfWqmvweqkstlivmlttlverGrvkChq YWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNgDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESlpHAGPIIVHCSAGIGRTGTI |||| . . .| .||. |. |..| || | .. .. . |.| . |||.|||||||... .|.|...... ... . |..||||||||||| . yWPetedelefgefsvrcekedetksyvlrelvlkdket-keerkilqlqylaWpdhgvPddsadflefvervrklrsg--keePvvvhCsaGigrtGvl IVIDMLMENISTKgldCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ |.... . | .. .. . . ....| ||. .|||..||||. || . illetalalieaa---epvypldivrtmrdqramlvqtvsqykfvCeailk |
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| Phosphatase | PTPN6.AA | Subfamily.N_Choan_2.PD | 268-516 | 36 | 7.4e-69 | 223.5 | In-house | 19-265 (266) | Show / Hide |
Range on Protein: 268-516 Range on HMM: 19-265/266 Sequence Identity: 36% (92 aa) PENKGKNRYKNILPFDHSRVILQGRDSNiPGSDYINANYIKnqllGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPE || |||..||| ..||.|. ... . . ||||||.. | |.. |.|||..| |..|...||.| |.|... ||||| .||||.|| |||. arnkrlnRyndiLPsPatRvrleeleed-sataYinAnyvr----GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa V---GMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPldnGDLIREIWHYQYLSWPDHGVPSEPG------GVLSFLDQINQRQESLPHAGPIIVHCSAGIG .. |.| .|... |. .. | |. |.. .. .|.. |..| .|||||||.|.. .|.| .... .. | .|.|..||||||.|||| epkekvkladgkikvlalseekeegyiltrlrlek---kgetrrlvHfwyntWpdhgvpreedsslstdqllkmlravrrvrkeldkaePllvHcsaGvg RTGTIIVIDMLMENISTKGldcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI |.|.||. .. ..... .|. . |. .| .| .||. ||...| |..... RtGtliaiDiavrlLeetk---kvdvlaiieelRkdRmalvqhpeqyellykavveya |
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| Phosphatase | PTPN6.AA | Subfamily.N14.PD | 245-516 | 35 | 1.1e-68 | 223.1 | In-house | 3-274 (275) | Show / Hide |
Range on Protein: 245-516 Range on HMM: 3-274/275 Sequence Identity: 35% (101 aa) WEEFESLQKQEVKNLHQrlEGQRPENKGKNRYKNILPFDHSRVILQGRDSNipGSDYINANYIKNQLLGpdeNAKTYIASQGCLEATVNDFWQMAWQENS . |.| ..|.. . | . .. |||. |||.|..||....|| |. | ..|||| || .. | . ..||..|| || ||.||||| |... fteyeripkkredalls--taklpenaeknrfkdvlPyednrvelsptken--stgyinassikvsvgg---kersyivaqgPleltvqdfwqmvweqgv RVIVMTTREVEKGRNKCVPYWPEVGM---QRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDlIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQ--- ..||| |.| |.|..|.. |.|. . . .| . ||. .|.. . ..|.. | .. |..|| || |||||||...| ||||.... . qlivmlteeeedgkeksfkylPkleskkktvefgkfkvttkfsedsdsvittglklkhlpske-ertvwhlqytDWpdhgvPeDvkgflsfLeevqsvrr RQE-SL----PHAGPIIVHCSAGIGRTGTIIVIDMLMENISTkglDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI . . . |..||||||.|||| .|. |.|.. . . . .|||.|.....| || .||| |||||.| ..... ktnsevesvkeskPPvlvhCsaGvGrtGvlilsdlliatleh---neeidikkvlarLrkqrmllvqtlaqykfvykvlikyl |
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| Phosphatase | PTPN6.AA | Subfamily.RK.PD | 244-514 | 35 | 6.7e-66 | 213.9 | In-house | 2-264 (267) | Show / Hide |
Range on Protein: 244-514 Range on HMM: 2-264/267 Sequence Identity: 35% (96 aa) FWEEFESLQKQEVKN-LHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNipGSDYINANYIknqllGPDENAKTYIASQGCLEATVNDFWQMAWQE . ||||.|. . . .....|. |||...||..|.|.|.|. | . ||||||..| .... .|. || |. ||.|||.. ..| lkeefetlnsvtpelqsedcdiakkdrnreknrsmdilaydrslvflisvdgd--ssdyinaali-----dsykrpaafivtqgPlqetvkdfWrlvyde NSRVIVMTTRE-VEKGRNKCVPYWPEVGMQRaYGPYSVTNCGEHDTTEYKLRTLQVSPLD-NGDLIREIWHYQYLSWPDH-GVPSEPGGVLSFLDQINQR |. ||| | ||.|| ||. |||| ...| ||. |. . ... |...|. | . . |||. ..|.|.||.. .|| ...|... .... || ncasivmlteldvevgrvkClkyWPedtevr-ygdikvelveaeldadlvvrifrveklargqeeirevrqfqflgWpeyrdvPvskrsllklirrvkks QESlPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLdcdIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ ..|.|.|||.|| ||.|| |.||...| | ..|. .|. .... .|.... ||.|| ||||.| .| . qee-eeeGrivvhClaGaGrsGtfiaidivlemieregv---vdvfnavktlrnrkvnmveteeqykfvydvile |
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| Phosphatase | PTPN6.AA | Subfamily.RG.PD | 244-515 | 34 | 1.4e-65 | 213.1 | In-house | 2-262 (264) | Show / Hide |
Range on Protein: 244-515 Range on HMM: 2-262/264 Sequence Identity: 34% (94 aa) FWEEFESLQKQEVKNLHQRlEGQRPENKGKNRYKNILPFDHSRVILQGRdSNIPGSDYINANYIKNQllgpdENAKTYIASQGCLEATVNDFWQMAWQEN . |.|| .|| . |... ...||| |||. ||.....||| |.. .. |.|||||.||. . .| ||..|| |. |..|||.| |..| leeqfeeiqklkpkdieae-sskkeenkeknReinivaversRvklspl-pgkdgkDYinAsyidGy-----rrskeyivtqgplketiedFWrmiWehn SRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNG-DLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQEs ...||| | .||||... |||. .. ..|| .. . .| .|.... .. .. |.. .|.| .|||.|.|. ||.| . .. .. aqiivmltdldekgrrdedvyWPkkdeplelealkvtllskeklskytvrdfvlkntkddkekervvrqyhytkWPdmgsPestlfvlifvkkeeaank- lPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGldcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF .||||.||.||| ||.|| |..| |.... .. ... ......||.| |.|.|| ||.||| |. .. -eeaGPivvhdsaGvgragtyialdtllqqlekee---avnvyqvlklirakRpglvtteEqyvfiydallel |
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| Phosphatase | PTPN6.AA | Subfamily.R_Ecdysozoa.PD | 244-516 | 33 | 9.9e-65 | 210.0 | In-house | 2-268 (269) | Show / Hide |
Range on Protein: 244-516 Range on HMM: 2-268/269 Sequence Identity: 33% (92 aa) FWEEFESLQKQEVKNLhQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNiPGSDYINANYIKNQllgpdENAKTYIASQGCLEATVNDFWQMAWQEN . ||.|.|... .. . ... ||. ||||..| .||. ||.|. . ||||||..|| .. |..||.|. .|||..|||.| .. . leeeyekLearleisk-stkvsekkenalknryedikafDktrvkLkkingk-edsdyinasfikgy-----kekkkfiaaqdPveatigDfWrmiaeqe SRVIVMTTREVEKGRNkCVPYWP-EvgMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDN--GDLIREIWHYQYLSWP-DHGVPSEPGGVLSFLDQINQ- . .||| . . || |. | ||| | . || |. |. ...| |.|.|| .. . |..|.| .|. | || . |.| ...|... . vtlivmlsnlteknrk-cakyWpie--devqygdilvklvseekhsdyiireldvskkkeesvedsrkvvqysytgWksDskvPevargllklieqvrel -RQE-SLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTkglDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI .. .||.|||||| ||.|... .|.|.... . . .|| .|.. .| ||. .|| .||.|.| |.|... yklnklsgsrsPivvhCsaGvgrsgifvaldlllqqlka---edkvdifetvkkLrsqrnllvqsleqyvflyraladys |
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| Phosphatase | PTPN6.AA | Subfamily.N1.PD | 249-514 | 34 | 1.4e-63 | 206.5 | In-house | 7-265 (268) | Show / Hide |
Range on Protein: 249-514 Range on HMM: 7-265/268 Sequence Identity: 34% (92 aa) ESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSnipgsDYINANYIKNqllgpDENAKTYIASQGCLEATVNDFWQMAWQENSRVIV ....|. .. . | ..|||.|.|||... |.||||..|. | |||||. .. .| . || .|| | |.. |||| |..||. .. leidkeskekeletreaklpenrglnryrdvspydhsrikleradv-----dyinaslvel-----eeakrrYiLtqGPLphtadHFWqmvWeqnskavi MTTREVEKGRNKCVPYWPEVGMQ--RAYGP--YSVTNCGEHDTTEYKLRTLQVSPLDNGDlIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLP | . |||...||. |||. . . ..|. |... .. .|.|.. |.. . .||| |..| ||| |||. | .|.|| .. . . mLnkvvEknqikCaqywpqeeeeaellleetklkvkliseerksyflvrlleLedletqe-treilhfhyttwpdfgvpespaafLkfLfkvresgsLss HAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ . ||...||||||||.||. ..| .. .| .| .||.| . .| .| |..|| | .| |.|| . dvgpavihCsagigrsgtlslvdtclveiektgdlnavdikkvLlelRkyRvGLiqtpdqLrFsyiaile |
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| Phosphatase | PTPN6.AA | Subfamily.RN.PD | 247-515 | 37 | 1.6e-60 | 196.3 | In-house | 5-262 (264) | Show / Hide |
Range on Protein: 247-515 Range on HMM: 5-262/264 Sequence Identity: 37% (101 aa) EFESLQKQEVKNLHQrLEGQRPENKGKNRYKNILPFDHSRVILQGRDsNIPGSDYINANYIKNQllgpDENAKTYIASQGCLEATVNDFWQMAWQENSRV |.|.| . | .. . .....| |||.|..||.||||| |. . . |||||| | .. | | .|||.|| | .|. ||||| |.. . | ewealcayeaepstk-evakaeknvkknrskavlpydhsrvklkeea-saeksdyinasaildh----dprapayiatqgplsstiadfwqmvweqGvvv IVMTTREVEKGRNKCVPYWPEVGMQrAYGPYSVTNCGEHD-TTEYKLRTLQVSPLDNGDlIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESlpH ||. || |.| ..| |||. | . |. | | || . .| .|.. . |.. . | . . .||||..|||... .| |..|. . ivnltrleeegvkqckrywpdeGse-vyhiyevhlvsehiwcddylvrsfylknlqtse-trtvtqfhflswpeegvPasaksllefrrkvnksyrG--r AGPIIVHCSAGIGRTGTIIVIDMLMENIsTKGLDcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF ||.||||.| ||||. |.||...|.. .||. .||| |.. .| ||.|.|.|..|..|.. |.|. scpivvhcsdGaGrtGvyilidlvlerl-lkGvk-eidiaatlehlrdqrpglvktkdqfefaltavaee |
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| Phosphatase | PTPN6.AA | Subfamily.RC.PD | 247-514 | 31 | 5.3e-59 | 191.5 | In-house | 5-285 (288) | Show / Hide |
Range on Protein: 247-514 Range on HMM: 5-285/288 Sequence Identity: 31% (93 aa) EFESLQKQEVKnlHQRLEGQRPENKGKNRYKNILPFDHSRVIL---------------QGRDSNI---PGSDYINANYIKNQllgpdENAKTYIASQGCL ||..| . | . .....||| |||| ..||.|. || | . |..| ||.|||| .|. . . |||.|| | efqrlpsvrsk--rtikiarkeenksknrysdvlpydynrvelkhelemskesehdsdessdddidseegskyinasfidsy-----kkpekyiaaqGpl EATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWpEVGmQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLiREIWHYQYLSWPDHGVPSEPGG . ||.|||.| ... .|||| |. | |.|| || | | .|||| | .. ...| || |.. . | ||. ..|| ||.....| || ketvddfwrmiferkvkvivmltelkeGdrekcaeyw-eeG-krayGdvevdlkdtdkssdyilrklelvnkkrkds-revtqiqytswsveqlpeepke VLSFLD----QINQRQES----LPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGldcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ .|.... .. |...| ...|..|||..| .|||. | .. |.| . .. .|. . .. .| .|..||..|.||...| .... llkliqvvkqklpqkrsseafknfkstpllvhcrdGsqrtGifiallallesleaee---kvdvfqvvkklrkarplmvsveeqyillydvlve |
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| Phosphatase | PTPN6.AA | Subfamily.N23.PD | 269-514 | 33 | 3.6e-54 | 175.8 | In-house | 101-347 (350) | Show / Hide |
Range on Protein: 269-514 Range on HMM: 101-347/350 Sequence Identity: 33% (81 aa) ENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLlgPdeNAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPE- | |... .. |..|| || .||||| |.|. | . ..||.|| ...|..|||.| |.. |.|||| |.|||... ||. |||. egsGqqqgtpdsrhdpnrvklqqstqpgqqddyinatylkelt--p--msPpfiatqgPiastlaDFWlmvweqqssviVmltkevegnklkcdqYwPid VGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNgDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQ-----ESL--PHAGPIIVHCSAGIGRT | .|...|. .... .. |.|... | . .|.. | .. .|...|||. |. .| ||.....|||.|||||.|||||. |. ...... egetnlfgdlrvslkslrssegwiervlhlqhndv-stvrlvchlhtttWseiGvPksPedllaflgevetayaqqrktetegeggkPiilhCsaGvgRt GTIIVIDMLMENIST-KGLdcdIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ .|. |.| . .. .|.|| |||.....|..| |. . gtfcvvysaireltagngi---iniprvvrrlrqqRkymvqkkvilkklyeavle |
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| Phosphatase | PTPN6.AA | Subfamily.N_Nematode_1.PD | 246-515 | 32 | 4.8e-53 | 171.8 | In-house | 4-263 (265) | Show / Hide |
Range on Protein: 246-515
Range on HMM: 4-263/265
Sequence Identity: 32% (88 aa)
EEFESLQKQEVKNLHQRLEGQrpENKGKNRYKNILPFDHSRVILQGRDSNipgSDYINANYIknqllGPDENAKTYIASQGCLEATVNDFWQMAWQENSR
.||..|.| . .. . .. . ....|||||.. |..||.|. . |||| |||. | |.| .| .|. |.|..||| |. ||.
defralkkfndeekvkafkea--qeadknrykdvgcldknrvklaeeplp---sdyihanyv-----gtptnpkrficaqaPldktiadfwymvlqekve
VIVMTTREVEKGRNKCVPYWPEVGMQ-RAYGPY----SVTNCGEHDT---TEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQIN
||| . .|||. || |.| . . . .| | . .. .| .... ... .|.|.. |||. |||.|||. ..| .|..... .
aivmlckliekgkkkcaeyfpakegeklefkekgqkitvenslgvkkleedeevikvtvlevegaGektrkvthyqWtdWPdrGvPpadlaalelleavr
QRQeslphaGPIIVHCSAGIGRTGTIIVIDMLMENIStKGLDCDiDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF
|||.|||||||||||||..|....... .| .. |..| ...| ||. .||.||| |.. . ..
gsk------gPivvhCsaGiGrtGtivaieyildkll-egkqie-dmeklvkkireqrnysiqtdaqylfvhrvllny
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| Phosphatase | PTPN6.AA | Subfamily.N20.PD | 254-512 | 39 | 8e-50 | 161.5 | In-house | 9-252 (257) | Show / Hide |
Range on Protein: 254-512 Range on HMM: 9-252/257 Sequence Identity: 39% (102 aa) QEVKNLHQRL-EGQRPENKGKNRYKNILPFDHSRVILqGRdSnipgSDYINANYIKNQLLGpdENaKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTR |.||| . |..| |. ||||..|||.| .|| | |. | |||||.||. | |. |||.|| | .|..||||| ..|||| | |||. lelknlpgefnsgnqpsnreknryrdilpydstrvpl-gk-s----kdyinasyirivncg--ee-yfyiatqgpllstiddfwqmvlennsnviamitr EVEKGRNKCVPYWPeVGMQRAYG--PYSVTNCGEHDTTEYKLRTLQVSPLDNGDlIREIWHYQYLSWPDHGVPSEpggVLSFLDQINQRQESLpHAGPII | | || ||| . ... . | . . .| .|| | . . . |. ||||| |. ||. |..| .||..||||| eieggiikcyhywp-islkkplelkhfrvflenyqilqyfiirmfqvvekstgt-shsvkqlqftkwpdhgtpas---adsfikyiryarksh-ltgpmv VHCSAGIGRTGTIIVIDMLMENISTkglDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAI |||||| ....|... | .| ..| . .| ||||||||. ||.| | . vhcsagigrtgvflcvdvvfcaivk---ncsfnimdivaqmreqrsgmvqtkeqyhfcydiv |
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| Phosphatase | PTPN6.AA | PTPc_motif | 408-514 | 41 | 1.7e-46 | 161.74 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 408-514 Range on HMM: 1-92/92 Sequence Identity: 41% (46 aa) EIWHYQYLSWPDH-----GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTE ...||.|..|||| |||. ..|.|...... ||.||||||.|||||...|||.|.. .|| .|....| || |||||| TVHHYHYTNWPDHVEKDSGVPE--DSILEFIRHVRK---------PIVVHCSAGCGRTGTFCAIDMMMQQ---------VDIFQTVKEMRKQRPGMVQTE AQYKFIYVAIAQ .||.|.| .|.. EQYIFCYRCILE |
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| Phosphatase | PTPN6.AA | Subfamily.N_Nematode_4.PD | 269-514 | 30 | 3.5e-46 | 149.4 | In-house | 25-261 (264) | Show / Hide |
Range on Protein: 269-514 Range on HMM: 25-261/264 Sequence Identity: 30% (77 aa) ENKGKNRYKNILPFDHSRVILQGRDsniPGSDYINANYIKNqllgPdeNAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEV .|. ||||..|| |..||.|. || | ||| |.... | . .||..|| |. |..||| | ..| |.||.|.| .|| |.|| . knsdknryadilcidetrvvlknrd---pdndyihaswmrm----P--dkfryistqGPlketlsdfwhmvytekiavvvmlcdlieegvekcaryypek GMQ-RAYGPYSVTNCGEHDT--TEYKLRTLQVSPLD-NGDLIR---EIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRqeslPHAGPIIVHCSAGIGRTG .| | .| .. .. |..|.|. . . | . |.|. |.|. | .. |. .. .... .. .||.||||||.||| |.. sekvvkfGkyritlvekkeeviadvilnslkvtntekkkdapseplvvkhvqvdwwrdqvaPldaapviklykavkkk----kkekPivvhcsaGvGrta TIIVIDMLMENISTKGldcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ ||. | .. .|.. . .. .|| | . ||.. |. |..| ... tlvGidyatirirens---eievldivrelramrlkavqshlqflfllvvlie |
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| Phosphatase | PTPN6.AA | Subfamily.R_Nematode_2.PD | 270-510 | 30 | 3.3e-44 | 142.8 | In-house | 29-254 (261) | Show / Hide |
Range on Protein: 270-510 Range on HMM: 29-254/261 Sequence Identity: 30% (74 aa) NKGKNRYKNILPFDHSRVILQGRDSNIPgsdyINANYIKNqllgpDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPE-V .| |.||... ....| . .| | ||.. ..| | .||.|| ||.|..||| |. ||. ||| ..||| ..|| |.| .. pkdkhRypdvPCkpetavevivdgkrvp----ihanwvpt-----agnpkrfiatqgPlentsedfWamviqekvekivmlcqkvekekekceeYfplet GMQRAYGPYSVTNCGEHDTTE--YKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLsflDQINQRQESlphAGPIIVHCSAGIGRTGTIIVI . | .|... ... . . |||.|. . | . |||| .|||.||| . ... ..| ||.||||||||||...| ... sqkldlgrfsiktvsaekilkdeiekrtlkvedstgkfatrtvthyqyeeWpdrgvPkshaelf---eLlelvkks---ekPivvhCsaGiGRtmafigt DMLMENISTkglDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYV | ... . | .| ...... .| .|. .||| |. .. . eylarevea---dptieltealkelrehRwkgiqtesqlywltl |
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| Phosphatase | PTPN6.AA | Subfamily.N_Nematode_6.PD | 269-514 | 30 | 1.7e-40 | 130.7 | In-house | 23-250 (253) | Show / Hide |
Range on Protein: 269-514 Range on HMM: 23-250/253 Sequence Identity: 30% (73 aa) ENKGKNRYKNILPFDHSRVILQGrDSNIpgsdYINANYIKNQllgpdENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPE- ..| .|||.|| .| .|. |.. | . || ||..| . . . .| .|. ||.|...||.|. . |||||||..|. | .. || . kfkdrnrytniqCcdagrlklad-dedf----yihanlvkis-----tkprrlictqaplegtieefwkmilssgveyivmlcelvekgkeksaeylsdk VGMQRAYGPYS-VTNCGEHDTTEYKLRTLQVSPLDNGDLIrEIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQEslphagPIIVHCSAGIGRTGTIIVI | .. . |.. |..| |.|.. . .. . . |... .||||||| . | .|. . . ||.||||||.|||||...| ...| vGdarkitklctvikigrkdidkilvrslkrivkagdeev-ivkhihWanWPdhGvPdsflsalrllsvvkkdkk------PivvhCsaGvGrtGtlali DMLMENISTKGldcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ . . ..... . .| .| |||| || . . . . liilealrlpd---fqgvkdllvklreerfravqtevqylyalrcvle |
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| Phosphatase | PTPN6.AA | Subfamily.R_Nematode_3.PD | 253-515 | 24 | 9e-39 | 125.1 | In-house | 11-265 (267) | Show / Hide |
Range on Protein: 253-515 Range on HMM: 11-265/267 Sequence Identity: 24% (67 aa) KQEVKNLHQRLegqrpENKGKNRYKNILPFDHSRVILQGRDSNiPGSDYINANYIKN--QLL-----GPDENAKTYIasqgcLEATVNDFWQMAWQENSR | .|| . .. ..|..... . ..||.|.| . .|.|.||... .| .| .. |. .|.. ||.|. ||.. . klakknatsls-----kkvsedrrvevpllektrvvLkgygkr-fkddfihAnvvecpnglklIltqsPqkkdkekk-----kkstieKfwwmieqekve VIVMTTREVE---KGRNKCVPYWPE-VGMQRAYGPYSV--TNCGEHDTTEYKLRTLQVsPLDNGDlIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQR .||. || .. .|| |.|| |. . . .|| |.. .. . . |||.| ...... |..| .|.....| || .|. .. ... . qvvmlcdfveedgeeeekcseYypekvdgelkfegvsvkctdikkelsedvekrtlvv-tfekkk-eftvthllykgWkelnapeepkealelikfveks QEslphagPIIVHCSAGIGRTGTIIVIDMLMENISTKGLdcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF |..||||.||.|..|. .|.. .. |... ..|. . |. .|.|| | .||| .. |. . | .. kt------pvvVHCsdGisRsatlaaielgyqliikskg--kldllslikelrkqRagaiqtelelafvilgilkl |
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| Phosphatase | PTPN6.AA | Subfamily.N_Nematode_5.PD | 269-516 | 25 | 1.2e-31 | 101.6 | In-house | 24-257 (258) | Show / Hide |
Range on Protein: 269-516 Range on HMM: 24-257/258 Sequence Identity: 25% (63 aa) ENKGKNRYKNILPFDHSRVilqgRDSNIPgSDYINANYIKNQLlgpdeNAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCvPYWP-E .|. |||.|.. |..|| . .. . ..||||..|| . |..| | | |..|||.| ||. .|. ... | . .. ..| | knlkknrskdvkilDetrV----kltded-dsYinaskikldd-----lekkliltQlPlpdteedFWrmvyqekitsvvllvedeelketav-sffple VGMQRAYGPYSVTNCG-EHDTTEYKLRTLQVSPLDNGDLiREIWHYQYLSWPDHGVPSEPGGVLSflDQINQRQESLPHA-GPIIVHCSAGIGRTGTIIV | .| ..| |....|.| |..| | .... . .|.. |... ||.. |..|.. .. . |..|....|.||.||...... tgdylnlgkmfinnrkvevkedekkeytvevlpegcses-vfakvyhlttWkkkkvPdkvkkvik--raiekvlskkqgknapvvvvsdlGlgRagtfll IDMLMENISTKgldCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI .|.. .. ..|.......| || |.|.. .|| ..| |....| lsvaieqlnng---kepnideilkkirsqRpgavesliqyasvyaavldyi |
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| Phosphatase | PTPN6.AA | Subfamily.N_Fungi_PTP1.PD | 271-371 | 39 | 1.4e-29 | 94.8 | In-house | 46-154 (343) | Show / Hide |
Range on Protein: 271-371 Range on HMM: 46-154/343 Sequence Identity: 39% (42 aa) KGKNRYKNILPFDHSRVILQ-------GRDSNIPGSDYINANYIKNQLLGPDENAKT-YIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCV |||||||||..||||.|. ... . ..|||||||.| . . . |.. ||| |. | ||.||... . . .||.. | .|| ...|| | faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy PYWPEVGMQ |.| ... rYWqegsyd |
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| Phosphatase | PTPN6.AA | Subfamily.N_Nematode_egg.PD | 246-517 | 23 | 2.7e-28 | 90.8 | In-house | 4-257 (257) | Show / Hide |
Range on Protein: 246-517 Range on HMM: 4-257/257 Sequence Identity: 23% (64 aa) EEFESLQKQEvkNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGsDYINANYIKNQLLgpdenAKTYIASQGCLEATVNDFWQMAWQENSR ..|| |.. . . ... | | | . . ||| |. | . |.| ||..| . | ..| .|| ||.|||.| .||. . | rrfeilersv--deislttaasdnylekarskrvhckessrvklelrrGqyld-dfihanrvkGkpl-----lnefilaqaplkntvedfwrmvfqekvq VIVMTTREVEKgrNKCVPYWPEVGMQRA---YGPYSVTNCGEHDTTE--YKLRTLQVSPLDngDLIREIWHYQYlSWPDHGVPSEPGGVLSFLdqinqRQ || | .| ..| ||| . . | . ..| . .. .. ... |.. | |. . |.|. . . | || | |. | yivmltsakes--erceyywpkaeseslvtvpGslrienlkvdskadplfrvtklklvGgd--deelflehwqg-dvnylsdvysplrvlrkl-----rn ESLphagPIIVHCSAGIGRTGTIIVIDMLMENIsTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIE |..|.. |. ...|.. |.. . .. .| ........| .| |.. .| |.| ...||. lsk----pvvvqdilGvskaatlvaieiallsl-lrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlffir |
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| Phosphatase | PTPN6.AA | Subfamily.N_Nematode_eak.PD | 258-516 | 25 | 5.8e-22 | 70.0 | In-house | 14-280 (281) | Show / Hide |
Range on Protein: 258-516 Range on HMM: 14-280/281 Sequence Identity: 25% (68 aa) NLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGsdYINANYIKNQLLGpdenaKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKG .| ...| |. .|| .|.|.|. | | | | |||| .. .| . || . | | ||||...| ||. .||.. . rllsirvtarleavnrnrvvkivpqdrylvrltssqlnrdG--yinaslaefsevG-----rkyiltGiasedkvfafwqmvleqkspaivqlledveek RNKCVPYWPEVGMQRAYGPYSVTnCGEH--DTTEYKLRTLQVSpldNGDLIREIWHYQYLSWPDHGVPSE-----------PGGVLSFLDQINQRQES-- | |.|. . . || . |. . |. .. | |... |. .. ||.. | ..| ||| .. .. .| leksdkyfpdktevlkyGildve-rkeyavkrniletrllilr---kGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallrstl -----L-PHAGPiIVHCSAGIGRTGTIIVIDMLMENISTKGLDcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI | | |. .. | |.|. .|||.|.. | | .... | |. .| | .. |. ||| .. ... kkyihtppsfap-iiqsarGsaraGvfvvidllirlidnkkkn-lysvedlilkvkskrihsvlvalqhsfiyeivldyl |
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| Phosphatase | PTPN6.AA | Subfamily.N_Fungi_PTP1.PD | 406-514 | 29 | 2.3e-18 | 57.9 | In-house | 212-340 (343) | Show / Hide |
Range on Protein: 406-514 Range on HMM: 212-340/343 Sequence Identity: 29% (36 aa) IREIWHYQYLSWPDHGVPSEPGGVLSFLD-------QINQRQES-LPHAGPIIVHCSAGIGRTGTIIVIDMLME------NISTKGLDCDI------DIQ |... |. |.| .. .| .|. |. . . .. . .. ||.||||||.|||||.. .|.|.. |.. | |. ... pyevyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlis KTIQMVRAQRSGMVQTEAQYKFIYVAIAQ .| || |||. |. ||| |. iivnelrkqrismvqnldqfifiYeallf |
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| Phosphatase | PTPN6.AA | Subfamily.PTPDC1.PD | 407-508 | 28 | 1.4e-12 | 39.2 | In-house | 133-220 (229) | Show / Hide |
Range on Protein: 407-508 Range on HMM: 133-220/229 Sequence Identity: 28% (28 aa) REIWHYQYlSWPDHGVPSepggVLSFLDQINQRQESLpHAGPIIVHCSAGIGRTGTIIVIDMLMENistkgldcDIDIQKTIQMVRAQRSGMVQTEAQYK ..| .|.. ...|.||.| . . || . . .| . | | ||| || |||| .| .. . ... .. |..||..|..|| | ... qgiyfynf-glkDygvas----leriLdivkvvdfal-eegkiavHCHAGlGRtGvliacylvyak--------rltaeeaiklvrskrpksiqtreqve FI lv |
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| Phosphatase | PTPN6.AA | Subfamily.DSP23.PD | 443-508 | 31 | 5.7e-08 | 24.6 | In-house | 63-120 (128) | Show / Hide |
Range on Protein: 443-508 Range on HMM: 63-120/128 Sequence Identity: 31% (20 aa) LPHAGPIIVHCSAGIGRTGTIIVIDMlmenISTKGLDCDidiqKTIQMVRAQRSGMVQTEAQYKFI . ... ||| |.|||||.. . . ..|| | ..| || .| | ..| | | . ekkeeavgvhcalGlGrtGtllacyl----vkeeglaad----daiaevrkrrkGsietveqekav |
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| Phosphatase | PTPN6.AA | Subfamily.CDC14.PD | 446-507 | 32 | 1.7e-07 | 22.8 | In-house | 198-250 (258) | Show / Hide |
Range on Protein: 446-507 Range on HMM: 198-250/258 Sequence Identity: 32% (20 aa) AGPIIVHCSAGIGRTGTIIVIDMLMENistkgldcDIDIQKTIQMVRAQRSGMVQTEaQYKF | |.||| ||.|||||.| .. . . . || .| | |.| . | .. eGaiavhCkaGLGrtgtligcylikhy--------rftaaetiawlriarPGsvigp-qqty |
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| Phosphatase | PTPN6.AA | Subfamily.PTEN.PD | 449-497 | 27 | 1.4e-06 | 19.6 | In-house | 97-141 (305) | Show / Hide |
Range on Protein: 449-497 Range on HMM: 97-141/305 Sequence Identity: 27% (13 aa) IIVHCSAGIGRTGTIIVIDMLMENISTKGLdcdiDIQKTIQMVRAQRSG ..||| || ||||..|. .|...| ... . . . .|.. . vavHCkaGkGRtGvmicayLlksgikksad----ealaiydekRtkdkk |
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| Phosphatase | PTPN6.AA | Subfamily.DSP19.PD | 441-495 | 29 | 1.5e-06 | 19.8 | In-house | 74-120 (139) | Show / Hide |
Range on Protein: 441-495 Range on HMM: 74-120/139 Sequence Identity: 29% (16 aa) ESLPHAGPIIVHCSAGIGRTGTIiVIDMLMENIStkgldcdIDIQKTIQMVRAQR |.. . | ..|||.||. |. .. || ||.. . ....|....||..| earskdgrvlvHCnAGvSRsasv-viaylmkdee-------lslekalekvrear |
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| Phosphatase | PTPN6.AA | Subfamily.DSP12.PD | 429-472 | 37 | 1.8e-06 | 19.8 | In-house | 63-106 (143) | Show / Hide |
Range on Protein: 429-472 Range on HMM: 63-106/143 Sequence Identity: 37% (17 aa) VLSFLDQINQR-QESLPHAGPIIVHCSAGIGRTGTIIViDMLMEN .||.||.... .|.| . | ..||| ||. | ||.. || . lLshldeavrFieeglekegavlvHClagvSRSvtivi-AYlmkk |
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