PTPRO
Species: Human
Alias: PTPRO, PTP-oc, PTPU2, GLEPP1, PTP-U2
External Links: COSMIC , Entrez Gene
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: Classic_PTP
Subfamily: RB
Protein domain

Protein domains of PTPRO.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Fn3 PTPRO.AA FN3 723-802 18 8e-07 29.92 SMART 1-69 (69) Show / Hide
Range on Protein: 723-802
Range on HMM: 1-69/69
Sequence Identity: 18% (18 aa)

PAPPKS---LFAVNKTQT------SVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTISSLLPA----TAYNCSVTSFSH--DSPS
| ||.    | ... | |      |||| | .       .| ..                    .|.. | |     | |. .|. ...  . ..
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR--------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG

Phosphatase PTPRO.AA PTPc 937-1197 40 7.50000000001e-128 431.96 SMART 1-308 (308) Show / Hide
Range on Protein: 937-1197
Range on HMM: 1-308/308
Sequence Identity: 40% (128 aa)

KFSLQFEELKLIGLDI---------PHFAADLPLNR--CKNRYT-NILPYDFSRVRLVSMNEE----EGADYINANYIPGYNSPQEYIATQGPLPETRND
.|. .||.|.  . ..         .   |..| ||  .||||. .|..|| .||.| . ..|    || ||||||||.||..| .||.||||||.| .|
GFWEEFERLQRMTPWDLMSNYDPCCSCTCACWPENREMDKNRYKCDIPCYDHTRVKLKPPPGESHCYEGSDYINANYIDGYWRPKRYICTQGPLPHTIED

FWKMVLQQKSQIIVMLTQCNEK--------RRVKCDHYWPFTEEPIAYGDITVEMISEEEQD-DWACRHFRINYAD----------EMQDVMHFNYTAWP
||.|| |||..|||||..|.||         |.||..||| .  |  ||.|||...|||  . |.  |.|.. . .          | . |.|..||.||
FWRMVWQQKCHIIVMLCNCMEKCTENRDQNGREKCHQYWPDE--PMTYGHITVTCKSEEKCPDDYTMRTFEVTNTGCNCKYSMACSETRTVTHYHYTNWP

DHGVPTANAAESILQFVHMVRQQATKS-------------------KGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTE
|||||  . ..|.|.|...||..   |                    ||...|||||.||||||.|.| ..|.|..   |||...|..||..|. |||||
DHGVP--ESPDSFLDFIRQVRHWQSHSPNMYMNMVSSNSKYHHTCPTGPIVVHCSAGCGRTGTFCAIDIMCQQIEN---VDIFQIVKMMRNQRPGMVQTE

EQYIFIHQCVQLMWM
|||||...|..   .
EQYIFCYRCILEYIK

Phosphatase PTPRO.AA Y_phosphatase 962-1194 46 1.8e-122 417.97 Pfam 1-243 (243) Show / Hide
Range on Protein: 962-1194
Range on HMM: 1-243/243
Sequence Identity: 46% (114 aa)

NRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPG-YNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRR-VK-CDHYWP--FTEE
|. ||||..|..||..||.| .....|. ||||||||.| |..|..||.||||.|.| .|||.||.|||...||||..| |. | .| |..|||    ..
NKEKNRYKDIPCYDHTRVKLQPIPGDEDSDYINANYIDGPYWNPKAYICTQGPMPHTIEDFWRMVWQQKCTCIVMLCNCMEMGRDEKTCHQYWPDNKEGQ

PIAYGDITVEMISEEEQDDWACRHFRINYAD----EMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQAT-KSKG--PMIIHCSAGVGRTGTFIAL
|. |||..|...|||. .|.  |.|..   .    | . |.|. ||.|||||||   .. |.|.|...||.. .    |  |...|||||.||||||.|.
PMTYGDFQVTCVSEEHCPDYTVRTFEVTN-GDQKQETRTVTHYHYTNWPDHGVPES-QPKSMLDFIRQVRKWQPNPDHGCPPIVVHCSAGCGRTGTFCAI

DRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQL
| ..|...... |||...|..||. |. ||||||||||..||.. 
DIMCQQMEHEGTVDIFQIVKHMRNQRPGMVQTEEQYIFCYQCILE

Phosphatase PTPRO.AA Subfamily.RB.PD 937-1195 55 4.5e-121 394.6 In-house 1-259 (261) Show / Hide
Range on Protein: 937-1195
Range on HMM: 1-259/261
Sequence Identity: 55% (146 aa)

KFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVML
.|| ..|||| .| | .. ||... ||.|||.||||||| |||.| ....|...||||||||||||||.||||||||||||..|||.||...||.|||||
rfseeyeelkkvgkdqavkaaeeavnraknrftnilpydhsrvkLaalkdesdtdyinanyipgynspreyiatqGPlpetvddfWrmvwekkssiivml

TQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPtaNAAESILQFVHMVRQQATKS--KGPMII
||. || ..||..||| .|||..||||.|....|.|.|.|..|.|.|.  .|...|.....|.|||||||  ......|.||..||....|.  |.|...
tqlvEkgkekceeYWPadeepvlyGdikvtllaekeldewvirefkiekgkekrkvrqyhftsWpdhgvP--ektktlldfvrtvreaiekkaskkPivv

HCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLM
||||||||||||||||||||.|.....||..|.|.|.|. |...||||.||||||.|.. .
HCsaGvGRtGtfialdrllqaieendyvdvfgvvaelReeRnllvqtekqyifiheclldl

Phosphatase PTPRO.AA Subfamily.R_Anemone_2.PD 953-1193 46 1.7e-91 297.8 In-house 18-258 (262) Show / Hide
Range on Protein: 953-1193
Range on HMM: 18-258/262
Sequence Identity: 46% (112 aa)

PHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWP
.|  | |. ||||.|||.|| .||.|  ...|||.||||||||.||.. ..|||||.||||| .|||.|| .|.|..||||||..|. ..|...|||  .
tlksalepvnkaknryanilaydktrvklqmlegeegsdyinanyidGyrrkkayiatqaPlpetiedfWrmvWeqnsavivmltqeeergkakvhryWP

fTEEPIAYGDITVEMISEEEQDDWACRHFRINYA--DEMQDVMHFNYTAWPDHGVPTANaaESILQFVHMVRQQA-TKSKGPMIIHCSAGVGRTGTFIAL
....||...||. .| | .|.  |.|...    .| ..|  |.||.|||.|||.     |.|..|  |..   ....||...||||||||||.|||.| |
-skgsrsygklvvelkeevelsdyvlrsfkvkrteeeeerqvrqfhytsWpdegvpesg--aslldlvrqvekaqqesgagpivvhcsaGvGrtGvfiav

DRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ
|..|.. . ||... |...|. |  ||||..||.||.. ..   
dillerikaealvdvfqtvkqlreqrnlmvqtkdqyefiydvll

Phosphatase PTPRO.AA Subfamily.N_Choan_1.PD 939-1193 44 7.1e-88 285.8 In-house 3-258 (262) Show / Hide
Range on Protein: 939-1193
Range on HMM: 3-258/262
Sequence Identity: 44% (112 aa)

SLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQ
..|.|. ||.| .  |.  . |. ||||.||  || .||..   .|.. .||||||..|||....||||||||.|.. ..||.||..|| ..|||.|.  
ieeyeklaeigvdntataskadenvlknrysnivayDatrvkvtpneenkntDyinanfvpgykgekeyiatqgPvPaslvsfWqmvweqkvsaivmvtr

CNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI-NYADEMQDVMHFNYTAWPDHGVPTAnaAESILQFVHMVR-QQATKSKGPMIIHC
|. ..|| .|||  .. . .||.||...||||.  ...|.|.. .   | ..| ...||||||||||... .|.| . |. .. .|.| |..||||||||
eieagklkChryWPdenselklgdvtvkslseeekktyierkfkleresgetreveqlaytaWPdhGvPat--tkellefrkavlkatkkktkaplvihC

SAGVGRTGTFIALDRLLQHIRDH-EFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ
||||.||||||....... | .|.  .|.|.|  |. ||||  || |....|.     
saGvGrtGtyialDrlvkaveekaealdvkavvaelrkernlmvqtlvqyefvykavl

Phosphatase PTPRO.AA Subfamily.R_Sponge_2.PD 956-1192 41 7.7e-82 266.1 In-house 19-257 (262) Show / Hide
Range on Protein: 956-1192
Range on HMM: 19-257/262
Sequence Identity: 41% (99 aa)

AADLPLNRCKNRYTNILPYDFSRVRLVSmNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFT-
.| |. |  |||...|||||.||||| . ......|||||... ||.... ||||||||.|| .|||.||. .|...|||||..|. . || .||| . .
iaklkenvgKnRfkeilpydmsRvrLrt-dgskdsDYinAsfvdgykrrkayiatqgPlketveDfWRmvweykvstivmltnleengkekcakYWPekv

EEPIAYGDITVEMISEEEQDDWACRHFRINYA---DEMQDVMHFNYTAWPDHGVPTAnaAESILQFVHMVRQQATKSKG-PMIIHCSAGVGRTGTFIALD
|   ||...| . .||.  |.. |..... .   .. .|| .|...|||.|.||.   | |.|....|... .||.. .....||.|||||||||||| .
deeveygkfkvtlkeeekladyiirklklskekssegeadvtqfhfvaWpehevPkd--atsllelikrvlraqkksgnkaitvvCsdgvgrtGtfiald

RLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
|....  | .|.  .. ..|. |. .||...|| |||. .  
svlerlkaeeeidvfevlktlrtkriglvqdaaqYvfihdal

Phosphatase PTPRO.AA Subfamily.R_Anemone_1.PD 942-1193 38 5.4e-81 263.4 In-house 6-254 (258) Show / Hide
Range on Protein: 942-1193
Range on HMM: 6-254/258
Sequence Identity: 38% (97 aa)

FEELKlIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNE
|..||  . .  . .|  . |. ||||..|...| ||| | .....| .||||| |. ...  ...||||.||.|| .|||.||.|.|...|||||. .|
fqrlk-eikeeekevarkaenkkknryadivaldhsRvvLeklsndeesdYinasylrasdktrafiatqapleetvedFWrmvwqekigviVmLtnlie

KRRVKCDHYWPFteEPIAYGDITVEMISEEEQDDWACRHFRINYADEM--QDVMHFNYTAWPDHGVPTAnaAESILQFVHMVRQQATKSKGPMIIHCSAG
..  || .|||   .. .||...|.. ..|.. |. .|.. .. ..|   . |.....| |||.|||.   | ..|.... |... .. . |...|||||
gekkkchqYwPd--stekygelrvslrkkevfadyiirtlvlskkketeerevvqyhftvWpdkgvPqy--atavLglrrkvqksslagarpvvvhCsaG

VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ
|||||.|...| .|.... .. |||   |  .|. |  ||||.|||.|||. |.
vgRtGaflvidamleqakkekvvDifnyvkairedrphmvqtkeqyvfihlavl

Phosphatase PTPRO.AA Subfamily.RG.PD 938-1193 39 5.6e-81 263.2 In-house 2-260 (264) Show / Hide
Range on Protein: 938-1193
Range on HMM: 2-260/264
Sequence Identity: 39% (103 aa)

FSLQFEELKL-IGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVML
.. ||||..     ||.  ..  . |. |||..||.... |||.| .. ...| |||||.|| ||.  .|||.|||||.|| .|||.|. ....||||||
leeqfeeiqklkpkdieaesskkeenkeknReinivaversRvklsplpgkdgkDYinAsyidGyrrskeyivtqgplketiedFWrmiWehnaqiivml

TQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYA--DEMQD--VMHFNYTAWPDHGVPTANAAEsiLQFVHMVRQQATKSKGPM
|. .|| | ..| |||  .||. .....| ..|.|....   |.| ..    |. ..  | ...|| |||.|.|. .. .  |||.   .  ... ||..
tdldekgrrdedvyWPkkdeplelealkvtllskeklskytvrdfvlkntkddkekervvrqyhytkWPdmgsPestlfv--lifvkkeeaankeeaGPi

IIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ
.|.||||||.||.|||| |||.....| |......  .|. |  .|.|||||.||.. .. 
vvhdsaGvgragtyialdtllqqlekeeavnvyqvlklirakRpglvtteEqyvfiydall

Phosphatase PTPRO.AA Subfamily.N12.PD 957-1194 42 1.4e-80 261.7 In-house 27-267 (270) Show / Hide
Range on Protein: 957-1194
Range on HMM: 27-267/270
Sequence Identity: 42% (104 aa)

ADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFT-E
.. . |. |||| .|||||.||| |  ..|||| ||||||.| | ....||||.|||||.| .|||.|. ... .|.||. .  |  . ||..||| . |
gekeenvkknrykDilPydksrvelskieeeegsdyinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCeryWpeege

EPIAYGDITVEMISEEEQD-DWACRHFRINYADEMQDVMHFNYTAWPDHGVPTAnaAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQ
|.. .|...|....|.  | |.  | ....  .| . |  |.||||||||||..  |.|.|.....||.  .... |...||||||||||| ||.|   .
eelefgefevtleeekavdddflirtLkveaqkesrkvyqfhytaWPDhgvPss--aksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvre

HIRD---HEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQL
 ...    | .|.  || |.|  | ..|||.||| .....|. 
llkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae

Phosphatase PTPRO.AA Subfamily.N5_RR.PD 957-1194 40 2.7e-77 251.1 In-house 18-262 (265) Show / Hide
Range on Protein: 957-1194
Range on HMM: 18-262/265
Sequence Identity: 40% (99 aa)

ADLPLNRCKNRYTNILPYDFSRVRLVSMN-EEEGADYINANYIPGYNSP-QEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFT
... .  ||||..||| . ||| | | . |.| ..||||||| ||.   . |.|||||||.| .|||.|. |...|.|||||. .|..| || .|.| .|
levfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntiadfWrmiyqeevqvivmltklkeanrqkcavyfPda

EEP---IAYGDITVEMISEEEQDDWACRHFRINYADE-MQDVMHFNYTAWPDHGVPTAnaAESILQFVH---MVRQQATKSKGPMIIHCSAGVGRTGTFI
.      |||. ... .  |..|.  |.. ..|. . ...|.|. ||.|||| .|    ....|..|.     |.....  .|...|||||.|||| |||
edyeiserygdveikveeiverndysvrklvlkylerversvkhywytdWPdhksPdd--intlldlvleveesreeenaklaPvvvhcsaGiGrtGcfi

ALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQL
 .  ....|....||.|..|...|  |  ||||.||| .||. . | 
aisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl

Phosphatase PTPRO.AA Subfamily.RK.PD 957-1192 39 5.5e-77 249.9 In-house 24-262 (267) Show / Hide
Range on Protein: 957-1192
Range on HMM: 24-262/267
Sequence Identity: 39% (95 aa)

ADLPLNRCKNRYTNILPYDFSRVRLVSMNEEeGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQC-NEKRRVKCDHYWPfTE
| .. || |||...||.|| |.|.|.|....  .|||||..| .|. |...|.|||||.|| .|||..|.....  |||||.   |. ||||.|||  . 
akkdrnreknrsmdilaydrslvflisvdgd-ssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmlteldvevgrvkClkyWP-ed

EPIAYGDITVEMISEEEQDDWACRHFRINY----ADEMQDVMHFNYTAWPDH-GVPTAnaAESILQFVHMVRQQATK-SKGPMIIHCSAGVGRTGTFIAL
 . |||| ||... | . |   | ||..      .|.. | .|....||.. .||.   ..|.|.... | ..  . ..|....||.|| ||.|||||.|
tevrygdikvelveaeldadlvvrifrveklargqeeirevrqfqflgWpeyrdvPvs--krsllklirrvkksqeeeeeGrivvhClaGaGrsGtfiai

DRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
 .|. |. .. ||.   | ..|.... ||.|||||.|... . 
divlemieregvvdvfnavktlrnrkvnmveteeqykfvydvi

Phosphatase PTPRO.AA Subfamily.RA.PD 956-1193 41 1.4e-76 248.8 In-house 21-262 (266) Show / Hide
Range on Protein: 956-1193
Range on HMM: 21-262/266
Sequence Identity: 41% (102 aa)

AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPfTE
.|... |. |||. .||||||||| |  .. || .||||| .| ||.  ...||.|||. || .|||.|. .|||. |||||. .|... ||||| .|  
tankeenkkknrvvqilpydfsrvilsvkeGeeesdyinasfidGyrekdkfiaaqGpkeetvedfwrmiweqksativmltelkerkeekcaqywp-de

EPIAYGDITVEMISEEEQDDWACRHFRINY-AD-----EMQDVMHFNYTAWPDHGVPTAnaAESILQFVHMVRQQATKSKG-PMIIHCSAGVGRTGTFIA
..||.|.||.  |..  |.. |.| ..  .|     . . |  | .|.||. |||.   .  .|.... |...  .| . |...|||||||||||||.||
GlvtyGeirvevkdetvledytvrdflvtqlpdatrekksrlvrqfhftswpevGvpae--gkGmlkllkkvkklqqqsanhpivvhcsaGvGrtGtfiv

LDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ
 .|. ..  . .|. . |...|  |  ||||.||| ||.. ..  
ldavlervkaerkldvfeavkrlrlqrpqmvqtleqyefiykvll

Phosphatase PTPRO.AA Subfamily.N9.PD 956-1192 42 2.1e-76 248.4 In-house 20-270 (275) Show / Hide
Range on Protein: 956-1192
Range on HMM: 20-270/275
Sequence Identity: 42% (101 aa)

AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTE
|. |..|  |||||..| || .|| | ...|.| .||||||.. ||. .. .|||||||..| .|||.|| .|.  .||| |.. |..|.||.||| .| 
asklranleknrytdvlcydetrvklakldedeasdyinanfvdGykqkkafiatqGplkktvsdfwrmvweqevlvivmttrvvergrlkcgqywplee

-EPIAYGDITVEMISEEEQDDWACRHFRIN--YADEMQDVMHFNYTAWPDHGVPTanAAESILQFVHMVRQQA-TK------------SKGPMIIHCSAG
. . .||..|. .. |...|.  |.. |.    .|.. |.|| ...|||.|||   .|.|.|.....||..  .|. |...|||||.|||||||.||  |
essaefgdlsvsnveveveedykvrvleiknvkteesrkvthfqflswPdyGvPs--saaslldvlekvrekqalavkelgdeskghlsgPPivvhcsaG

VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
..... . ||.   |. .|. |  ..||.||| | ...|              
iGrtGtfitldiclarleevgtvdvvetvkllrtqrafsiqtpeqyefcylav

Phosphatase PTPRO.AA Subfamily.N3.PD 949-1193 41 2.5e-75 244.5 In-house 13-257 (261) Show / Hide
Range on Protein: 949-1193
Range on HMM: 13-257/261
Sequence Identity: 41% (103 aa)

GLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEeegaDYINANYI----PGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRR
..   || .| |  |||| .|||||  ||.|.. .     |||||||.    |. .  . ||||||||..| .|||.|| .|||..|||||.  |. |||
kpglaisaarkpenlaknryrdilpydatrvklkeset----dyinanyvnmeipstglvnryiatqGplaktakdfWqmvweqkstlivmlttlverGr

VKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYAD--EMQDVMHFNYTAWPDHGVPTANaaESILQFVHMVRQQATKSKGPMIIHCSAGVGR
| .||| ||. . .|...|.. .|.|.  .  |.. .. ..  | . .... |.||||||||. .  ...|.||. ||.  ... |...|||||.|||| 
vkChqyWPetedelefgefsvrcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPdds--adflefvervrklrsgkeePvvvhCsaGigr

TGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ
.|.|.  |. |  .| | .| .|..||  |...|||..|| |. ...    
tGvlilletalalieaaepvypldivrtmrdqramlvqtvsqykfvCeail

Phosphatase PTPRO.AA Subfamily.N_Choan_2.PD 962-1193 38 3.6e-75 243.9 In-house 21-262 (266) Show / Hide
Range on Protein: 962-1193
Range on HMM: 21-262/266
Sequence Identity: 38% (93 aa)

NRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYN-SPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTE-EPIA
|.  |||..|||   .|||| ...|.. . ||||||..|.. ....|||..|||| | ..||.|....|.. |||.|. .|| |||. |||    | ...
nkrlnRyndiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

Y--GDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANA----AESILQFVHMVRQQAT--KSKGPMIIHCSAGVGRTGTFIALDR
  |.|.|  .||| .. .  .. |... .|.....|| |..|||||||...     ....|. .. ||..  . ..|...|||||||||||.||.|  ..
ladgkikvlalseekeegyiltrlrlekkgetrrlvHfwyntWpdhgvpreedsslstdqllkmlravrrvrkeldkaePllvHcsaGvgRtGtliaiDi

LLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ
 .  .. ||.| ...|.| .|| .||. ||| .... |.   
avrlLeetkkvdvlaiieelRkdRmalvqhpeqyellykavv

Phosphatase PTPRO.AA Subfamily.N6.PD 960-1194 41 3.2e-73 238.0 In-house 38-292 (295) Show / Hide
Range on Protein: 960-1194
Range on HMM: 38-292/295
Sequence Identity: 41% (104 aa)

PLNRCKNRYTNILPYDFSRVRLVSM-NEEEGADYINANYI--------PGYN--SP---QEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRV
. |. |||| ||||.| .|| |    ..  |.||||||||         | |  |    ..||||||.|..| .|||.|| |..|..|||.|. .|. . 
ienkeknryknilPfDhtrvilkdgepsvpgsdYiNanyirlpkaskssgenveseehqkryiatqgcLkdtvsdFWrmvwqensrvivmttkevergkn

KCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINY---ADEMQDVMHFNYTAWPDHGVPTAnaAESILQFVHMVRQQA--TKSKGPMIIHCSAGV
|| .||| .|.  ..|.|||..|||....|.  |.| ..     .|.. .......||||||||.   .. .|.|.. |.......||...|||||.|||
kCarYWPdeetkketGvitvtsisEkstadYtlRefsvshkdkdkeareifqyhfkaWPdhgvpkd--pgvvlnfledvnkkqeelekagpivvhcsaGi

GRTGTFIALDRLLQHIRDHEF---VDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQL
|||| .| .|. |. . .   .||   . ..||.|  .||||.||.|. ..||    
GrtGtfividivlkiieqsgldvdidisksikdvrsqrsglvqteaqykfvykavqf

Phosphatase PTPRO.AA Subfamily.R_Ecdysozoa.PD 942-1192 36 6.1e-73 236.7 In-house 6-264 (269) Show / Hide
Range on Protein: 942-1192
Range on HMM: 6-264/269
Sequence Identity: 36% (95 aa)

FEELK-LIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCN
.|.|.  .  .    ...   | .|||| .| ..|  ||.|  .| .| .|||||..| ||.  ...|| |.|. .| .|||.|. .|....||||.. .
yekLearleiskstkvsekkenalknryedikafDktrvkLkkingkedsdyinasfikgykekkkfiaaqdPveatigDfWrmiaeqevtlivmlsnlt

EKRRVkCDHYWPFTeEPIAYGDITVEMISEEEQDDWACRHFRINYAD-----EMQDVMHFNYTAWP-DHGVPtaNAAESILQFVHMVRQQAT-----KSK
|| |  |..|||   . . |||| |...|||...|.. |.. .   .     . . |. ..||.|.|  ||  ..|...|.....||.         |..
eknrk-cakyWpie-devqygdilvklvseekhsdyiireldvskkkeesvedsrkvvqysytgWksDskvP--evargllklieqvrelyklnklsgsr

GPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
|...||||||||.|.|.||| |||...  . |||.  | ..|| |  .||  |||.|... . 
sPivvhCsaGvgrsgifvaldlllqqlkaedkvdifetvkkLrsqrnllvqsleqyvflyral

Phosphatase PTPRO.AA Subfamily.N13.PD 962-1192 40 3.4e-70 227.9 In-house 26-254 (259) Show / Hide
Range on Protein: 962-1192
Range on HMM: 26-254/259
Sequence Identity: 40% (96 aa)

NRCKNRYTNILPYDFSRVRLvsmnEEEGAdYINANYIP--GYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFT-EEPI
|. |||| |.|||| .||.|    ..||. ||||..|     .   ||||.||||||| .|||.|| .||...|.|.|.  || .|||. ||| . ....
nkdknryrnvlPydetrvkl----gdegg-yinaslikvpvgedeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPerknkkl

A-YGDITVEMISEEEQDDWACRHFRINY--ADEMQDVMHFNYTAWPDHGVPTAnaAESILQFVHMVRQQATkSKGPMIIHCSAGVGRTGTFIALDRLLQH
  .. ..||..  ...|... |.. ..   . | ..|.|.|...|||||||..  |....|||  ||. .| ..||...|||||.||.|..|..| .|. 
kvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPss--aaelvqfvaevrllqt-dagPivvhcsaGiGrsGvlitidvvlgl

IRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
|  .. .|.  .| ..|  | ..|||..||||... .
ierdkefdvkeivrklreqrqgvvqtkdqyifvykai

Phosphatase PTPRO.AA Subfamily.RC.PD 956-1192 33 5.7e-66 214.1 In-house 20-283 (288) Show / Hide
Range on Protein: 956-1192
Range on HMM: 20-283/288
Sequence Identity: 33% (90 aa)

AADLPLNRCKNRYTNILPYDFSRVRL-------------------VSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVML
|  . |. ||||...||||. || |                     .. |||..|||| .| .|  |. |||.|||| || .|||.|. ..| ..|||||
iarkeenksknrysdvlpydynrvelkhelemskesehdsdessdddidseegskyinasfidsykkpekyiaaqGplketvddfwrmiferkvkvivml

TQCNEKRRVKCDHYWpfTEEPIAYGDITVEMISEEEQDDWACRHFRINYADE--MQDVMHFNYTAWPDHGVPTANaaESILQFVHMVRQQ---A------
...|  | || .||   |   ||||. |..  ..   |.  | . .    .   ..|....||.|.....|     . .|.....|.|.           
telkeGdrekcaeyw--eeGkrayGdvevdlkdtdkssdyilrklelvnkkrkdsrevtqiqytswsveqlpeep--kellkliqvvkqklpqkrsseaf

-TKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
    .|...||..|..|||.||||. ||. .   | ||. ..| ..|  |  ||..|||||.... . 
knfkstpllvhcrdGsqrtGifiallallesleaeekvdvfqvvkklrkarplmvsveeqyillydvl

Phosphatase PTPRO.AA Subfamily.N1.PD 952-1189 37 1.3e-59 193.2 In-house 18-260 (268) Show / Hide
Range on Protein: 952-1189
Range on HMM: 18-260/268
Sequence Identity: 37% (93 aa)

IPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEeegaDYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW
... .|.|| || .||| .. ||| ||..| . .     |||||. .   .  ..|| ||||||.| . ||.|| .|.|. ..|| .. ||...|| .||
letreaklpenrglnryrdvspydhsrikleradv----dyinaslveleeakrrYiLtqGPLphtadHFWqmvWeqnskavimLnkvvEknqikCaqyw

PFTEEP--IAYGD--ITVEMISEEEQDDWACRHFRINY--ADEMQDVMHFNYTAWPDHGVPTANAaeSILQFVHMVRQQAT--KSKGPMIIHCSAGVGRT
|  ||   . . .  ..|..||||... .  |.....    .|.. ..|| || ||| |||.. |  ..|.|.. ||.  .  .. ||..||||||.||.
pqeeeeaellleetklkvkliseerksyflvrlleLedletqetreilhfhyttwpdfgvpespa--afLkfLfkvresgsLssdvgpavihCsagigrs

GTFIALDRLLQHIRDHEF---VDILGLVSEMRSYRMSMVQTEEQYIFIH
||.  .| .| .| ...    |||   . |.|.||. ..|| .|  |  
gtlslvdtclveiektgdlnavdikkvLlelRkyRvGLiqtpdqLrFsy

Phosphatase PTPRO.AA Subfamily.N14.PD 942-1192 34 4.3e-55 178.2 In-house 6-270 (275) Show / Hide
Range on Protein: 942-1192
Range on HMM: 6-270/275
Sequence Identity: 34% (91 aa)

FEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEeGADYINANYIPGYNS--PQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQC
.|...   .|    .| || |  |||. ..|||. .||.|.. .|.   .||||  |    .   ..||..||||..| .|||.|| .|.|.|||||. .
yeripkkredallstaklpenaeknrfkdvlPyednrvelsptken-stgyinassikvsvggkersyivaqgPleltvqdfwqmvweqgvqlivmltee

NEKRRVKCDHYWPFT---EEPIAYGDITVEMISEEEQDDWACRHFRINYA--DEMQDVMHFNYTAWPDHGVPTA-NAAESILQFVHMVRQQATKSK----
|. . |. .|.| .   .. . .|   |     |. |  . . .....    | ..|.|. || |||||||   .   | |. |. ||.......     
eedgkeksfkylPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsfLeevqsvrrktnsevesvk

---GPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
   |...||||||||||  |  | |.. .   | .||   .. .|  ||..|||  || |... . 
eskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLrkqrmllvqtlaqykfvykvl

Phosphatase PTPRO.AA Subfamily.N_Nematode_1.PD 964-1192 36 8.4e-54 174.0 In-house 28-260 (265) Show / Hide
Range on Protein: 964-1192
Range on HMM: 28-260/265
Sequence Identity: 36% (88 aa)

CKNRYTNILPYDFSRVRLVsmNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPI-AYG-
||||...   | .||.|   .|   .||| |||.     |. .| .|.|| .| .||| ||||.| . |||| .. || ..|| .|.| .|..   .   
dknrykdvgcldknrvkla--eeplpsdyihanyvgtptnpkrficaqaPldktiadfwymvlqekveaivmlckliekgkkkcaeyfpakegeklefke

---DITVEMIS---EEEQDD--WACRHFRINYA-DEMQDVMHFNYTAWPDHGVPTANAAesILQFVHMVRqqatKSKGPMIIHCSAGVGRTGTFIALDRL
   ||||  .     |.|.      ......| .. . | |...| |||.|||.|. |  .|.... ||    .||||...|||||.||||| .|.. .|
kgqkitvenslgvkkleedeevikvtvlevegaGektrkvthyqWtdWPdrGvPpadla--alelleavr----gskgPivvhCsaGiGrtGtivaieyi

LQHIRD-HEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
... . ..  |.  || ..|. |   .||. ||.|.|. . 
ldkllegkqiedmeklvkkireqrnysiqtdaqylfvhrvl

Phosphatase PTPRO.AA Subfamily.N23.PD 977-1191 34 5e-53 171.7 In-house 117-344 (350) Show / Hide
Range on Protein: 977-1191
Range on HMM: 117-344/350
Sequence Identity: 34% (79 aa)

SRVRLV-SMNEEEGADYINANYIPGYN--SPqEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTE-EPIAYGDITVEMISEEE
.|| |  | . ..  ||||| |.      || ..||||||...| .|||.|| .|.|..|||||. .|. . |||.|||  | |.  .||..| . |...
nrvklqqstqpgqqddyinatylkeltpmsP-pfiatqgPiastlaDFWlmvweqqssviVmltkevegnklkcdqYwPidegetnlfgdlrvslkslrs

QDDWACRHFRINY--ADEMQDVMHFNYTAWPDHGVPTAnaAESILQFVHMVRQQA-----TKS----KGPMIIHCSAGVGRTGTFIALDRLLQHIRDHE-
 . |  | ....   .. ...|.|...|.|...||| .   |..|.|.. |..       |.     . |.|.||||||||||||  .   .. .. .. 
segwiervlhlqhndvstvrlvchlhtttWseiGvPks--PedllaflgevetayaqqrktetegeggkPiilhCsaGvgRtgtfcvvysaireltagng

FVDILGLVSEMRSYRMSMVQTEEQYIFIHQC
 ..|. .|...|  |  |||..... .. . 
iiniprvvrrlrqqRkymvqkkvilkklyea

Phosphatase PTPRO.AA Subfamily.R_Nematode_2.PD 961-1190 30 4.7e-51 164.9 In-house 28-254 (261) Show / Hide
Range on Protein: 961-1190
Range on HMM: 28-254/261
Sequence Identity: 30% (72 aa)

LNRCKNRYTNILPYDFSRVRLvsMNEEEGADyINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFT-EEPIA
|.. |.|| ..   . ..|.   . ... .. | ||..|  . |. .||||||| .|..||| || |.| . ||||.|. ||. ||..|.| . .. .  
lpkdkhRypdvPCkpetavev--ivdgkrvp-ihanwvptagnpkrfiatqgPlentsedfWamviqekvekivmlcqkvekekekceeYfpletsqkld

YGDITVEMISEEE--QDDWACRHFRINYADE---MQDVMHFNYTAWPDHGVPTANaaESILQFVHMVRqqatKSKGPMIIHCSAGVGRTGTFIALDRLLQ
| ..... |.|.  .|.   | .... .      . |.|. |. |||.||| ..    . . ...|.    ||. |...|||||.|||..||. . | ..
lgrfsiktvsaekilkdeiekrtlkvedstgkfatrtvthyqyeeWpdrgvPksh--aelfeLlelvk----ksekPivvhCsaGiGRtmafigteylar

HIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ
.  .. . .  .. |.|..|.  .|||.|. ...  
eveadptieltealkelrehRwkgiqtesqlywltl

Phosphatase PTPRO.AA Subfamily.N20.PD 952-1192 39 1.5e-50 163.6 In-house 16-252 (257) Show / Hide
Range on Protein: 952-1192
Range on HMM: 16-252/257
Sequence Identity: 39% (94 aa)

IPHFAADLPLNRCKNRYTNILPYDFSRVRLVsmneeEGADYINANYIPGYNSPQEY--IATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDH
. . | || |||| .||||| .|| |      .  |||||.||   |  .||  |||||||  | .|||.|||...|..| |.|.|   .|| |||| . 
gefnsgnqpsnreknryrdilpydstrvplg-----kskdyinasyirivncgeeyfyiatqgpllstiddfwqmvlennsnviamitreieggiikcyh

YWPFT-EEPIAYGDITVEMISEEEQDDWACRHFRINY--ADEMQDVMHFNYTAWPDHGVPTanAAESILQFVHMVRQQatKSKGPMIIHCSAGVGRTGTF
..|.    . | .   .  . .  | |..    .   . | ....| ||||| |.  .|.|......  |.   .|||..|||||.|||| |...| .. 
ywpislkkplelkhfrvflenyqilqyfiirmfqvvekstgtshsvkqlqftkwpdhgtpa--sadsfikyiryarks--hltgpmvvhcsagigrtgvf

IALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
 |     ..|. .|..||  |  ||||.||| | .. |        
lcvdvvfcaivkncsfnimdivaqmreqrsgmvqtkeqyhfcydiv

Phosphatase PTPRO.AA Subfamily.RN.PD 960-1192 35 1.2e-48 157.1 In-house 25-259 (264) Show / Hide
Range on Protein: 960-1192
Range on HMM: 25-259/264
Sequence Identity: 35% (85 aa)

PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQ-EYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEpI
. |  |||....|||| |||.| . ...|  |||||  |   .  .  ||||||||..|  |||.|| .| . .||.||. .|.   .|..||| . .  
eknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplsstiadfwqmvweqGvvvivnltrleeegvkqckrywpdeGs-e

AYGDITVEMISEEE-QDDWACRHFRINY--ADEMQDVMHFNYTAWPDHGVPTAnaAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQH
 |.   |...||    ||.  | | .    ..| . |  | . .||..|||..  | |.|.|   | .       |...|||.|.||||..|..| .|..
vyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPas--aksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvler

I-RDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
. .    .||   .  .|  |  .|.|..|. |. ..|
llkGvkeidiaatlehlrdqrpglvktkdqfefaltav

Phosphatase PTPRO.AA Subfamily.N_Nematode_4.PD 964-1192 31 1.3e-47 153.8 In-house 28-259 (264) Show / Hide
Range on Protein: 964-1192
Range on HMM: 28-259/264
Sequence Identity: 31% (73 aa)

CKNRYTNILPYDFSRVRLvsMNEEEGADYINANYIPGYnSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEP-IAYGD
||||..||  | .|| |   | .   ||| |...       .||.|||||.|| .||| || ..| ...||| .  |.||  |.| ..|    .|.  ..
dknryadilcidetrvvl--knrdpdndyihaswmrmP-dkfryistqGPlketlsdfwhmvytekiavvvmlcdlieegvekcaryypeksekvvkfGk

ITVEMISEEEQ--DDWACRHFRINYAD---EMQD----VMHFNYTAWPDHGVPTAnaAESILQFVHMVRQqaTKSKGPMIIHCSAGVGRTGTFIALDRLL
.. ..|.   | . . ...   .   .       | |.... |.|.  |    | ......|..   |...|...||||||||| |.. .|   ..||. 
yritlvekkeeviadvilnslkvtntekkkdapseplvvkhvqvdwwrdqvaPld--aapviklykavkk--kkkekPivvhcsaGvGrtatlvGidyat

QHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
  ...| .| |.|. |.  ||.. |..|.  ..      
irirenseievldivrelramrlkavqshlqflfllvvl

Phosphatase PTPRO.AA PTPc_motif 1091-1194 46 1.9e-46 161.56 SMART 1-92 (92) Show / Hide
Range on Protein: 1091-1194
Range on HMM: 1-92/92
Sequence Identity: 46% (51 aa)

DVMHFNYTAWPDH-----GVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQY
 |.|. ||.||||     |||.    .|||.|...||.       |...|||||.||||||.|.| ..|.      |||...| |||..|. ||||||||
TVHHYHYTNWPDHVEKDSGVPE----DSILEFIRHVRK-------PIVVHCSAGCGRTGTFCAIDMMMQQ------VDIFQTVKEMRKQRPGMVQTEEQY

IFIHQCVQL
||...|.. 
IFCYRCILE

Phosphatase PTPRO.AA Subfamily.N_Nematode_6.PD 962-1192 35 1.8e-44 143.5 In-house 24-248 (253) Show / Hide
Range on Protein: 962-1192
Range on HMM: 24-248/253
Sequence Identity: 35% (82 aa)

NRCKNRYTNILPYDFSRVRLVsmneEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFT-EEPIAY
.. .||||||  .| .|..|.    ..   || ||..     |. .| ||.|| .| ..||||.| . .. |||| .  ||. |. .| . .  .   ..
fkdrnrytniqCcdagrlkla----ddedfyihanlvkistkprrlictqaplegtieefwkmilssgveyivmlcelvekgkeksaeylsdkvGdarki

GDI-TVEMISEEEQDDWACRHF-RIN-YADEMQDVMHFNYTAWPDHGVPtaNAAESILQFVHMVRqqatKSKGPMIIHCSAGVGRTGTFIALDRLLQHIR
.. ||  |.....|    |   ||   .||   | |... .|||||||  ..  | |... .|.    |.| |...|||||||||||.. .  .|. .| 
tklctvikigrkdidkilvrslkrivkagdeevivkhihWanWPdhGvP--dsflsalrllsvvk----kdkkPivvhCsaGvGrtGtlaliliilealr

DHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
 .| ..  |.  .|  |.  |||| ||.. ..|| 
lpdfqgvkdllvklreerfravqtevqylyalrcv

Phosphatase PTPRO.AA Subfamily.R_Nematode_3.PD 966-1194 25 2.5e-38 123.4 In-house 27-264 (267) Show / Hide
Range on Protein: 966-1194
Range on HMM: 27-264/267
Sequence Identity: 25% (62 aa)

NRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSpQEYIATQGPL--------PETRNDFWKMVLQQKSQIIVMLTQCNE---KRRVKCDHYWPFT
.|..... .  .|| |.        |.|.||..   |.  . | ||.|.         .| . ||.|. |.|....||| ..|   .   || .|.|   
drrvevpllektrvvLkgygkrfkddfihAnvvecpng-lklIltqsPqkkdkekkkkstieKfwwmieqekveqvvmlcdfveedgeeeekcseYypek

-EEPIAYGDITVEM--ISEEEQDDWACRHFRINYADEM-QDVMHFNYTAWPDHGVPTAnaAESILQFVHMVRqqatKSKGPMIIHCSAGVGRTGTFIALD
.. .  ....|.   |..| ..|   |...... ..    | |  |..|.....|    ....|. ...|.    ||| |...|||.|..|..|. | . 
vdgelkfegvsvkctdikkelsedvekrtlvvtfekkkeftvthllykgWkelnapee--pkealelikfve----ksktpvvVHCsdGisRsatlaaie

RLLQHIRDHE-FVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQL
  | |  ..  .|.| |..|.|. |   .|||....|.  ..   
lgyqliikskgkldllslikelrkqRagaiqtelelafvilgilk

Phosphatase PTPRO.AA Subfamily.N_Nematode_5.PD 962-1192 23 1.4e-35 114.1 In-house 25-253 (258) Show / Hide
Range on Protein: 962-1192
Range on HMM: 25-253/258
Sequence Identity: 23% (55 aa)

NRCKNRYTNILPYDFSRVrlvsMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYG
|  |||....  .| .||    ....|  .||||..|   .. ...| || |||.| .|||.||.|.| . .|.|.. .|. ... .   |..   .|..
nlkknrskdvkilDetrV----kltdeddsYinaskiklddlekkliltQlPlpdteedFWrmvyqekitsvvllvedeelketavsffpletgdylnlg

DITVEMISEEEQ----DDWACRHFRINYADEmQDVMHFNYTAWPDHGVPTANAAEsILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIR
....   |..    . .    .  . ...   ... ..| |... ||.  ..  |   .. |.. .... |.......|.||.|||..|.   . . . .
kmfinnrkvevkedekkeytvevlpegcses-vfakvyhlttWkkkkvPdkvkkv-ikraiekvlskkqgknapvvvvsdlGlgRagtflllsvaieqln

DHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
 ..|  .. ..|| |. .|..  || .....|   
ngkepnideilkkirsqRpgavesliqyasvyaav

Phosphatase PTPRO.AA Subfamily.N_Nematode_egg.PD 962-1193 26 1.8e-29 94.3 In-house 26-253 (257) Show / Hide
Range on Protein: 962-1193
Range on HMM: 26-253/257
Sequence Identity: 26% (61 aa)

NRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKrrVKCDHYWPFTE-EPIAY
.. | |   .   ..|||.|   .     |.| ||.. |    .|.| .| || .| .|||.|| |.| | |||||   |.|..||| .| |.. .  | 
ylekarskrvhckessrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvedfwrmvfqekvqyivmltsakes--erceyywpkaeseslvt

--GDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWpDhgVPTANAAESILQFVHMVRQQATkskgPMIIHCSAGVGRTGTFIALDRLLQH-IR
. .| .  ... |   |  ...     .. .. ..  . |  |  ..   | |. ...|. ..    |.....  || ...|..|..  | . .|   . 
vpGslrienlkvdskadplfrvtklklvGgddeelflehwqg-d--vnylsdvysplrvlrklrnlsk----pvvvqdilGvskaatlvaieiallsllr

DHEF-VDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ
  .|  |  .|  |   |..  .|.|... |      
Gpitkslvlravvflrlrrrlsvesvllylfvyrlvl

Phosphatase PTPRO.AA Subfamily.N_Fungi_PTP1.PD 964-1072 41 1.3e-27 88.1 In-house 47-165 (343) Show / Hide
Range on Protein: 964-1072
Range on HMM: 47-165/343
Sequence Identity: 41% (51 aa)

CKNRYTNILPYDFSRVRLV-S-------MNEEEGADYINANYIPGY------NSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDH
.||||.|||||. |||.|  |           .. |||||||.         |.   |||||.|||.| .||.|..|. | ..|..||.  |  . ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPfteePIAYGDITVEMISEEE
||.      .| |||| . |  |
YWq----egsydditvklaskwe

Phosphatase PTPRO.AA Subfamily.N_Nematode_eak.PD 965-1108 30 6.8e-20 62.9 In-house 29-172 (281) Show / Hide
Range on Protein: 965-1108
Range on HMM: 29-172/281
Sequence Identity: 30% (43 aa)

KNRYTNILPYDFSRVRLVSMNEEeGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDIT
.||  .|.|.|.  ||| |   .    ||||  .   .  ..|| |  .  .    ||.|||.|||  ||.| .  |..| | |.|   | . || . ||
rnrvvkivpqdrylvrltssqln-rdGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledveekleksdkyfpdktevlkyGild

VEMISE-EEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTA
  .   ...    | . ..  .|   |.|...  | .  .|    
verkeyavkrniletrllilrkGnethrvlhykvfGwtettlpky

Phosphatase PTPRO.AA Subfamily.N_Fungi_PTP1.PD 1088-1194 31 7.3e-19 59.3 In-house 211-340 (343) Show / Hide
Range on Protein: 1088-1194
Range on HMM: 211-340/343
Sequence Identity: 31% (39 aa)

EMQDVMHFNYTAWPDHGvpTANAAESILQFVH---------MVR-QQATKSKGPMIIHCSAGVGRTGTFIALDRLLQH------IRDH--------EFVD
|   |.....  |.| .  . .  ||||| .          . .    ..   |...|||||||||||...|| ||......        .  | |  .|
epyevyqlqvknWkDls--lllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrD

-ILGLVSEMRSYRMSMVQTEEQYIFIHQCVQL
 |.|. |.||||. .|.|||.....       
lisiivnelrkqrismvqnldqfifiYeallf

Phosphatase PTPRO.AA Family.DSP.PD 1080-1202 20 4.8e-12 37.3 In-house 148-253 (387) Show / Hide
Range on Protein: 1080-1202
Range on HMM: 148-253/387
Sequence Identity: 20% (23 aa)

HfrinyadeMQDVMHFNYtAWPDHGVPTANAAesILQFVHMVRQQAtKSKGPMIIHCSAGVGRTGTFIALDRLLQhiRDHEFVDILGLVSEMRsyRmSMV
... . .. ...||..|. .    . ...  . ..  .|||   .|| ||.||.|| |.  .. .  .. .. . | .|.. |. .... ...  |..| 
k--------elgikylri-pidDhnapplenl--fekaidfieegn-dskgvVlVHCkaGkgRsgtliiaYlmks--egltleealdwvrskR--p-gvi

QTEEQyiFIHQCVQLMWMKKKQ--Q
 .|. .| |.  .            
tpnqg--flkqlkdlekeklkvsse

Phosphatase PTPRO.AA Subfamily.PTPDC1.PD 1090-1193 28 1.3e-11 35.8 In-house 133-225 (229) Show / Hide
Range on Protein: 1090-1193
Range on HMM: 133-225/229
Sequence Identity: 28% (29 aa)

QDVMHFNYtAWPDHGVPTAnaaESILQFVHMVRQQAtkSKGPMIIHCSAGVGRTGTFIALdrLLQHIRDhefVDILGLVSEMRSYRMSMVQTEEQYIFIH
|.....|. ...|.||..    |.||. | .| .    ..| . .|| || ||||  ||    | . ..   ..    .. .|| |.|| ||  ....  
qgiyfynf-glkDygvasl---eriLdivkvvdfal--eegkiavHCHAGlGRtGvliac--ylvyakr---ltaeeaiklvrskrpksiqtreqvelve

QCVQ
.   
eFal

Phosphatase PTPRO.AA Subfamily.DSP23.PD 1110-1185 30 8.9e-09 26.9 In-house 48-117 (128) Show / Hide
Range on Protein: 1110-1185
Range on HMM: 48-117/128
Sequence Identity: 30% (23 aa)

AAESILQFVHMVrQQATKSKGPMIIHCSAGVGRTGTFIALdrLLQHIRDHEFVDilgLVSEMRSYRMSMVQTEEQY
| | . ..|..| ..| |..... .||  |.|||||..|    | . ..    |    . |.|  |   ..| || 
aleqvarlvriv-eeaekkeeavgvhcalGlGrtGtllac--ylvkeeglaadd---aiaevrkrrkGsietveqe

Phosphatase PTPRO.AA Subfamily.CDC14.PD 1124-1155 45 1.1e-06 19.9 In-house 193-223 (258) Show / Hide
Range on Protein: 1124-1155
Range on HMM: 193-223/258
Sequence Identity: 45% (14 aa)

QATKSKGPMIIHCSAGVGRTGTFIALdRLLQH
. |..| ...|| ||.|||||.|.   |..| 
itekaeGaiavhCkaGLGrtgtligc-ylikh

Phosphatase PTPRO.AA Subfamily.PTEN.PD 1091-1149 29 7.6e-06 16.9 In-house 61-114 (305) Show / Hide
Range on Protein: 1091-1149
Range on HMM: 61-114/305
Sequence Identity: 29% (17 aa)

DVMHFNYTawpDHGVPTANAAESILQFVHMVRQQatKSKGPMIIHCSAGVGRTGTFIAL
|...  .   ||  || .  |.| . |..  ..   ..  ...|| || ||||. |.  
rvavypfd---DhnpptleLleeivedvdkwLke--dksnVvavHCkaGkGRtGvmica

Phosphatase PTPRO.AA Subfamily.N_Nematode_eak.PD 1112-1192 24 9.9e-06 16.4 In-house 194-276 (281) Show / Hide
Range on Protein: 1112-1192
Range on HMM: 194-276/281
Sequence Identity: 24% (20 aa)

ESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIR--DHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV
.| |    . . . |      || .. |  |.|.|. .| |.. |    ..   .  |.  ..| |.  | .. |. ||.. |
ksallrstlkkyihtppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeiv

Sequence
Name Sequence Type Origin Length Description Download
PTPRO.AA Protein None 1216 None Fasta, JSON
PTPRO.NA RNA None 3648 None Fasta, JSON
PTPRO.AA.PD_937-1197 Protein Phosphatase Domain None 261 None Fasta, JSON