• Phosphatome.Net

Gene GAK

GAK
Species: Human
Alias: DNAJC26, GAK, DNAJ26, auxilin-2
External Links: COSMIC , Entrez Gene
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: DSP
Subfamily: Auxilin
Protein domain

Protein domains of GAK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GAK.AA GAK 40-313 70 1e-236 792.71 In-house 1-277 (277) Show / Hide 
Range on Protein: 40-313
Range on HMM: 1-277/277
Sequence Identity: 70% (195 aa)

LRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKG-QLVEFLKKME
.|||.|.|||||||||.||||..||||||||.||.....|||||.|.|.||||.||.||||||.|..|..|||...|||.|||.|.||. |||..||.||
YRVRCVIAEGGFAFVYVAQDVQTGREYALKRMLSHDMQANRAIINEICMMKKLQGHENIVQFCDASYISREESNQSQAEYLLLMEYCKFSQLVDCLKRME

SRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNF
...|.|||.||.||||.||||||||.|||||||||.|.||.|..||.||||||||||||.|||||||||||.|..||.|..|.||||||.||..|||||.
CYKPFSCDCVLRIFYQMCRAVQHMHSQKPPIIHRDIKIENFLIGNQKTIKLCDFGSATTKSHYPDYSWSAQKRSMVEDEMFRHTTPMYRSPEMCDLYSNW

PIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYS--IPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQL
|||.||||||.||.||..|.|||||||||||||.||.|.  |||.|.||..||.||||.|||||.|||.||.||...
PIGHKQDIWAMGCMLYFMCYRQHPFEDGAKLRIINGNYMKPIPPQDNQYMCFHDLIRACLQVNPDERLDIAMVVEYM
Kinase GAK.AA NAK 40-313 43 5.3e-163 547.8 In-house 1-299 (299) Show / Hide 
Range on Protein: 40-313
Range on HMM: 1-299/299
Sequence Identity: 43% (129 aa)

LRVRRVLAEGGFAFVYEAQ---------DVGSGREYALKRLLSN-EEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQ
..|...||||||..|| .|         .. .|..|||||.... .|....|...|...||||..|.||||.....  ....|......|||....|.|.
YTVEKYLAEGGFSYVYLVQDNYINHPDNPNSNGEKYALKRMICHSDEQDLNACKREIEMMKKLQHHNNIVQYIDSHINERDDSNGTWEVFLLMEYCCHGS

LVEFLKKME--SRGPLSCDTVLKIFYQTCRAVQHMHRQKP--PIIHRDLKVENLLLS---NQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNT
|.... |.   . .....| .|.||...|..||.||...|  ||||||.|.||.|||   ..|..|||||||.||....|...|.||.|..|...| ..|
LWDLMNKRLMDKGTCFTEDEILQIFCDVCEGVQAMHQCQPPKPIIHRDIKIENILLSESHHDGNYKLCDFGSMTTAIIQPENRWEAQYRSMVQDWINKYT

TPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFED------GAKLRIVNGKYS--IPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQL
||||| ||..|||||.||.||.|||||||.|| .||..|||||      ..||.|.||.|.  ||......  .|.|||.||...||.|..|..|..||
TPMYRAPEMCDLYSNCPIDEKVDIWALGCMLYKMCFYTHPFEDCYQRHDSSKLAIQNGNYKYSIPDNSRYSQQMHDLIRYMLTPDPEQRPNIYQVLNQL
Kinase GAK.AA NAK-Unclassified 40-315 25 2.4e-76 259.97 In-house 1-405 (405) Show / Hide 
Range on Protein: 40-315
Range on HMM: 1-405/405
Sequence Identity: 25% (104 aa)

LRVRRVLAEGGFAFVYEAQ--------D------VGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTEL
 .. | ||||||.||| ..        |         .  |.||| .  .||   .   |.  ||.. .|||||.     .| .|   ..  | ..| |.
YTIVRYLAEGGFSFVYLVKFSKYINPPDNTASVPHSNSNMYCLKRMICQDEESLNTMKREIDVMKRFRNHPNIVKYI-DHHIMRENHNNQSYEVFMLMEY

CK-GQLVEFLK------KME-SRGPLSCDTVLKIFYQTCRAVQHMHRQKP--------------------------------------------PIIHRD
|. | |..|        .   .   ..   .|.|....|...| || . |                                            |.||||
CSRGSLQDFMNNQRTIYQRLTEQTRFHEQECLQIMSDVCQGIQCMHQHQPRQDNATSRVNVDAVSMTYSDETAMLLEDTPLEMDMLSSNSAGSIPLIHRD

LKVENLLLS----------------------------------------------------------NQGTIKLCDFGSATTISHYPDYSWSAQRRALVE
.|.|| |..                                                          . |  |||||||....   .     .| .. ..
IKIENVLFCNLRRPSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSEDSEHNGIYKLCDFGSCCECIITIE---NRQEMQYLQ

EEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLR-------IVN--GKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSI
..| ..||| || ||.||||.. || || ||||||| || .||   |||..  |        | .  |||..|.  .    .|.||. ||...| .|..|
DWINMHTTPQYRAPEMIDLYRCCPIDEKIDIWALGCFLYKMCFYTTPFEMCGQLHNASVTYKILHGLGKYEFPSNHNYSNQLHNLIKIMLNEDPIQRPNI

AEVVHQLQE
 .|  .. .
YQVLNHICQ
Kinase GAK.AA BIKE 40-312 40 6.6e-76 258.49 In-house 1-267 (267) Show / Hide 
Range on Protein: 40-312
Range on HMM: 1-267/267
Sequence Identity: 40% (113 aa)

LRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQF--CSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKM
  |  .||||||| |. ..| .    .||||   | |.   .   |. .||..||| ||| .  |.  .||      |  | ..|.| |..|.|. . . 
VTVEEQLAEGGFAMVFLVRDHKG-NKCALKRMYVNNEHDLNVCCREHQIMKQCSGHKNIVGYVDCYINCIGN-----GVWECMILMEYCRHQVVNMMNQR

ESRG-PLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQG--TIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDL
 . |  .  . ||.||  .| ||  .|  . ||||||||||| ||...|     ||||||||.    |     ..    |..|| ..||  || || |||
LQQGQYFTEQEVLQIFCDVCEAVSRLHHCQTPIIHRDLKVENILLHDHGPPHYVLCDFGSATNKFLNPQ----KHGVNYVKDEIEKYTTMCYRAPEMIDL

YSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQ
||  .|. | |||||||.|| |||   ||.   .| | .|...||         | ||| || . .| | .|  | | 
YSGKEITTKADIWALGCMLYKLCFFCLPFGE-SQLAICDGNFTIPDNSKYSREMHCLIRYMLEPDMEKRPDIYQVSHV
Kinase GAK.AA S_TKc 40-317 25 6.3e-56 193.03 SMART 1-231 (231) Show / Hide 
Range on Protein: 40-317
Range on HMM: 1-231/231
Sequence Identity: 25% (73 aa)

LRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKG---QLVEFLKK
 .. |.. .|.|. || ......||..|.|..        . |..|.  .||  .|||||..  .             .. . .|.| |    | ...||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLFDYIKK

MESRGP---LSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIID
. ..|.   ..  .. ...||.|.|....|..   ||||||| ||.||..  .||.||||.|. .                    |   || |. ||.. 
RGRHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL-------------------TTFCGTPWYMAPEVL-

LYSNFPIGE-KQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVH-----QLQEIA
     . |  | |.|..||||| .. .. ||.     .. .              . ..|| .||..||.|... |. .      . .  
-----GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GAK.AA Pkinase 40-313 22 1.6e-51 182.24 Pfam 1-293 (293) Show / Hide 
Range on Protein: 40-313
Range on HMM: 1-293/293
Sequence Identity: 22% (72 aa)

LRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQ----EVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKG-----QL
... |.. .|.|. ||.....|.|...|.|..   .|...  ..     |.. ||.| .|||||..  .             .  . .|.| |      |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------KDHIYMVMEYCEGGLYVMDL

VEFLKKMESRGPL--SCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTI----KLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTP
 ....  ...|..  | ... ...||..|.....|..   ||||||| ||.|..|.|.|    |.||||.|  ..               .   |.  ||
FDYIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----------Y-NNS-MTTFCGTP

MYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDG------AKLRIVNGKYSIPPHDTQY-----------------------TVFHSLIRAM
 |. ||.|   .. ..| | |.|..||||| ..... || .        .. ... . . |.|   .                         . ..|. .
WYMAPEVIR--GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

LQVNPEERLSIAEVVHQ--L
|...|..|........   .
LCKDPKKRPTAEQILQHPWF
Phosphatase GAK.AA CAMK 45-309 18 1.3e-46 147.84 In-house 1-419 (425) Show / Hide 
Range on Protein: 45-309
Range on HMM: 1-419/425
Sequence Identity: 18% (78 aa)

VLAEGGFAFVYEAQDVGSG------------REYALKRLLSN----------------------------EEEKNRAIIQEVCFMKKLSG------HPNI
.| .|.|. |.....  ..            ...| | .  .                            .... . . .|.. ||||.|      ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQFCSAASIGK------EESDTGQA-------EFLLLT---ELCKGQ-----LVEFLKKMES------------RGPLSCDTVLKIFYQTCRAVQHMHRQ
...  .   ..      . ..| .        .. . .   |.| |      | ..... ..            || .. . . ..| | | ||...| .
IKLYEVYEDPHYFKNTND-YET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

KPPIIHRDLKVENLLLSNQ-----------------GTIKLCDFGSATTISHYPDYS-------------WSAQRRALVEEEIT--------RNTTPMYR
.  |.||||| ||.||..                  ..||..||| |. . .  ..              |           ..        .  || | 
N--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQW----------TTPTEGQKMKTFCGTPEYM

T-PEIIDLYS-----------NFPIGEKQDIWALGCILYLLCFRQHPFEDG-----------------AKLRIVNGKYSIPPHDTQYTV-----------
  ||..   .           . ..|.| |.|..|.||| .     ||..                   . .| .|||. ||.    .            
AAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDI

-----------FHSLIRAMLQVNPEERLSIAEV
             .||| ||||.||.|..|...
SDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQC
Kinase GAK.AA TKL-ciliate1 119-313 25 2.7e-38 128.66 In-house 74-279 (279) Show / Hide 
Range on Protein: 119-313
Range on HMM: 74-279/279
Sequence Identity: 25% (55 aa)

FLLLTELC-KGQLVEFLKKMES-RGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATT-ISHYPDYSWSAQRRALVE
| . .|.| || ... . .  |   ... .  ... .   . .|..|  ..|.||||||..|.|..     | |.|.. ..   |      .    . . 
FYIIMEHCHKGTMFDICHRKHSQIYMIKWQHRMRWCKDIAQGMQYLHMRQNPLIHRDLKMQNILYDEPYQYKICNFPHVKIADFHR----IRNCSFQDMQ

EEITRNTTPMYRTPEIID--LYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHD------------TQYTVFHSLIRAMLQVNPE
.|. ||||.... ||..|  ...| || || ||.|.| ..| ||||  ||.   |.  .|.   ..                    || |.  ..  || 
NEMQRNTTFHWMAPEQMDPHIFPNYPINEKIDIYAYGIVMYILCFRKTPFQQ--KMSVINIMCYWCEFPGRPNLGPQFIHFDCPQNFHNLMMRCWCQNPN

ERLSIAEVVHQL
 | .  |.   |
KRPNFNEIIQIL
Kinase GAK.AA TKL 46-313 18 3.5e-38 133.18 In-house 1-364 (364) Show / Hide 
Range on Protein: 46-313
Range on HMM: 1-364/364
Sequence Identity: 18% (70 aa)

LAEGGFAFVYEAQDVG--------SGREYALKRLLS------------------------NEEEKNRAIIQEVCFMKKLSG--HPNIVQFCSAASIGKEE
. .|||. || ..  |        .|.. | |.. |                        |..|  ..  .|.  .. .|   |||||||  ..  ..  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

SDTGQA-----EFLLLTELC-KGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQK------PPIIHRDLKVENLLLSNQGT-------------
   ..      .. . .|.| .| | ..|           .  ... ....|.....| ..      ||||||||| .|.|. . .|             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-IKLCDFGSATTISHYPDYSWSAQR-------RALVEE-EITRNTTPMYRTPEIID---LYSN----------FPIGEKQDIWALGCILYLLCFRQHPFE
 .|.|||| ....|.  . . ..         . . ..  .|.  || .  ||...    |..          |.  || |... | .|. .. |..|..
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

DGA--------------KLRIVNGKYSIPP---------HDTQYT--VFHSLIRAMLQVNPEERLSIAEVVHQL
|                ......|.   .|          .  ..   . .|.    . .||.|.|  |....|
DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GAK.AA Ciliate-E2 40-309 19 6.8e-38 127.65 In-house 1-359 (365) Show / Hide 
Range on Protein: 40-309
Range on HMM: 1-359/365
Sequence Identity: 19% (72 aa)

LRVRRVLAEGGFAFVYEAQDVGSGREYALKR--------------------LLSNEEEKNRAIIQEVCFMK---------------KLSGHPNIVQFCSA
  . ... .|.|. ||....   ....|.|.                    . .... . ..| ||   |.               ..  ||||...  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

ASIGKEESDTGQAEFLLLTELCKGQ-LVEFLKKM-ESR-------GPLSCDTVLKIFYQTCR---------------AVQHMHRQKPPIIHRDLKVENLL
     .| |.    . | .|.|.|. | ...|..  .|       .....  ...|..| ..               |....| ... |||||.| ||.|
----FQEKDDNN--IYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENIL

LSNQGTIKLCDFGSATTIS-HYPDYSWSAQRRALVEEEI--------------TRNT------TPMYRTPEIIDLYS------NFPIGEKQDIWALGCIL
.     ||..||| .. ..  . ...   |.. .  .                  |.      ||.|  |||.   .        . ..| |||.||.||
F-----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

YLLCFRQHPFEDGAKLRIVNGKYSIP----------------PHDTQYTVFHSLIRA----MLQVNPEERLS-IAEV
| ..| ..||       | ..|...|                 ..        ||.     |||..||.|.. . ..
YEMLFGKPPF----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI
Kinase GAK.AA CMGC 40-254 18 3.4e-35 112.44 In-house 1-326 (513) Show / Hide 
Range on Protein: 40-254
Range on HMM: 1-326/513
Sequence Identity: 18% (60 aa)

LRVRRVLAEGGFAFVYEAQD--------------VGSGREYALKRLLSNEEEKNRAI------------IQEVCFMKKLS----------------GHPN
  . ... || .. ||...|                .....|.|.. ... ... |             . |. ..|.|.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVQ---FCSAASIGKEESDTGQA------EFLLLTELCKGQLVEFLKKME--SRG----PLSCDT------------VLKIF------YQTCRAVQ--HM
||.   ..      ..|... .       .. | .|..   | ...|..    .|    |||               . ...      || .|..   ..
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HRQKPPIIHRDLKVENLLLSNQ--------------------GTIKLCDFGSATTISHYPDYSWSAQR-------------RALVEEEITRNTTPMYRTP
|...  ||||||| ||.|....                    |..|.||||.|. .....|   . |.             |.. ..  ||     || |
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRW----YRAP

EIIDLYSNFP-------IGEKQDIWALGCILY
||.  ...          ... |.|..|||..
EILLGWKHYTNHNYSMHYTTPIDMWSVGCIFA
Phosphatase GAK.AA Subfamily.PTEN.PD 409-565 29 3.5e-31 97.7 In-house 1-161 (305) Show / Hide 
Range on Protein: 409-565
Range on HMM: 1-161/305
Sequence Identity: 29% (47 aa)

DISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNLSPR-TYRPSRFHNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVH
||||| . . |.|.|.| .|  |..|..|. ..|.... |.. ...|. | ..  | |..||.. .     .|.|. | .|..... || .|..|| .||
disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavH

CMDGRAASAVAVCSFLCFCRLFSTAEAAVYMFSMKRCPPG---IWPSHKRYIEYMCDMVAE
|  |.  . | .|..| .   ...|. |. ... ||   .     || .||..|   .|  
CkaGkGRtGvmicayLlksgikksadealaiydekRtkdkkGVtiPSQrRYvqYfsklvks
Kinase GAK.AA CAMKL 121-198 32 2.2e-20 61.6 In-house 98-179 (297) Show / Hide 
Range on Protein: 121-198
Range on HMM: 98-179/297
Sequence Identity: 32% (27 aa)

LLTELCKGQ---LVEFLKKMESRG-PLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQG--TIKLCDFGSATTI
| .|.| |    | ....| . |. ... .   ..| | . ||...|...  |.|||.| ||.||...|  .||..||| .. .
LVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG--IVHRDIKPENILLDENGNNNIKIIDFGFSNMY
Kinase GAK.AA Pkinase_Tyr 40-193 25 6.3e-16 54.56 Pfam 1-156 (270) Show / Hide 
Range on Protein: 40-193
Range on HMM: 1-156/270
Sequence Identity: 25% (41 aa)

LRVRRVLAEGGFAFVYEAQDV----GSGREYALKRL--LSNEEE-KNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKG-QLV
..  ..| || |  ||..       . . . | | |   . .|. . .. ..|.  ||.|  |||||..  . .  .| .     . .. .|....  | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-----QIYIVMEYMPHGDLL

EFLKKM-ESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFG
..|.|  |...||.  . |.. .| ... .. ....  .|||||   | |.......| ||||
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFG
Kinase GAK.AA TyrKc 40-313 19 1.1e-13 -1.65 SMART 1-280 (280) Show / Hide 
Range on Protein: 40-313
Range on HMM: 1-280/280
Sequence Identity: 19% (59 aa)

LRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKL-SGHPNIVQFCSAASIGKEESDTGQ---AEFLLLTELCK-GQLVEFL
..  ..| || |  ||...     .. | | | ..     .....|   |.||   |||||..  ... ...            ....|... | | ..|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN----FMYIEPLMIVMEYMPHGDLKDYL

KKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHY---PDYSWSAQRRALVEEEITRNTT-PMYRT--
.| . .  |. .. |.. .| ..  .. |..  ..|||||   | |.....|.| .||| .  | ..               ....  | ..    .|  
RKHRPK--LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-----------ESKDYYRKKEHKGGKTML

------PEIIDLYSNFPIGEKQDIWALGCILY-LLCFRQHPFED---------GAKLRIVNGKYSIPPHD--------TQYTVFHSLIRAMLQVNPEERL
      || |  |. |   .| |.|. |  .. .. . | | ..          .  .. .|..  .|..            ..  ...   . .||.| 
PIRWMAPECI-NYGKF--TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRP

SIAEVVHQL
. .|.....
TFSEIHECF
Kinase GAK.AA CAMKL 241-310 34 8.3e-13 37.06 In-house 214-292 (297) Show / Hide 
Range on Protein: 241-310
Range on HMM: 214-292/297
Sequence Identity: 34% (28 aa)

GEKQDIWALGCILYLLCFRQHPFEDGA-----------KLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVV
| | |||..| ||| . . . ||.|             ...|  | | .|..       ..||| |||||||.| .| ...
GPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIM
Kinase GAK.AA CAMKL 40-101 23 4.5e-09 24.95 In-house 1-80 (297) Show / Hide 
Range on Protein: 40-101
Range on HMM: 1-80/297
Sequence Identity: 23% (19 aa)

LRVRRVLAEGGFAFVYEAQDVGS-GREYALKRLL----SNEEEKNRA-----------IIQEVCFMKKLS--GHPNIVQF
 |. ..| .|.|. |  |...   |...| | .     .|.. ...            | .|.. ||.|.  .||||...
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKL
Phosphatase GAK.AA PTEN_C2 570-709 27 3.2e-40 144.74 Pfam 1-141 (141) Show / Hide 
Range on Protein: 570-709
Range on HMM: 1-141/141
Sequence Identity: 27% (41 aa)

PHSKPILVRAVVM-TPVPLFSKQRSGC-RPFCEVYVGDERVASTSQEYDKMRDF-KIEDGKAVIPLGVTVQGDVLIVIYHAR-STLGGRLQAKMASMKMF
|..||. .....|  ..| | ||. || ||....| .|. | .|...| ....  . .... ..| ...|||||.| .|| . |.| . .  ..    ||
PPPKPLFLHCIIMDHGIPNF-KQGGGCWRPYIQIYQNDQKVFYTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDL-PWMYEEC----MF

QIQFHTGFVPRNATTVKFAKYDLDACDIQ---EKYPDLFQVNLEVEV
...|.|.|...| ....| |..|| .. .   ...|. |.| .  . 
RFWFNTCFIEHNNNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE
Phosphatase GAK.AA Subfamily.Tensin.PD 465-705 28 4.2e-39 123.4 In-house 1-233 (237) Show / Hide 
Range on Protein: 465-705
Range on HMM: 1-233/237
Sequence Identity: 28% (71 aa)

FHNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCFCRLFSTAEAAVYMFSMKR-----CPPGIWPSHKRYIEYM
....| . ||    || |. |  ||.....||  | .|| |.||  |.   .| ..... . .. ..|.||. .|..||       . .|| .||.||. 
lnekvldlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyf

CDMVAEePITPHSKPILVRAVVMTPVPLFSKqRSGCRPFCEVYVGDERVaSTSQEYDKMRDfKIEDGKAVIPLGVTVQGDVLIVIYHARSTLGGRlqakm
.....  |   |.|...  |..  .| |   ..|||||  .| . . |  ||  |    . . |    .|  .. ..||||.  || .     |      
sgllsg-siklnssplflhyvilhgipnfds-kggcrpflkiyqalqlv-ytsgvynvage-dterlcitiepalllkgdvlvkcyhkklrsttr-----

asMKMFQIQFHTGFVprNATTVKFAKYDLDACDIQEKYPDLFQVNL
   .|..||||| .  . ... | | |||    .|..|.  .|.| 
--dvvfrvqfhtgai--kdlklvfekedldealkderfpeyakvel
Phosphatase GAK.AA Subfamily.TPIP.PD 465-563 29 9.4e-19 56.9 In-house 1-107 (245) Show / Hide 
Range on Protein: 465-563
Range on HMM: 1-107/245
Sequence Identity: 29% (31 aa)

FHNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCFCRLFSTAEAAVYMFSMKRCPPG-------I-WPSHKRYI
|||||| .       |.|. |  ...... || .| .|| ..||  |.     .||..|    .|.||| ... |. .|           .|| .||..|
fhnrvsrimiddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryv

EYMCDMV
. ..   
gylaqvk
Phosphatase GAK.AA Family.DSP.PD 469-699 18 1.1e-18 56.7 In-house 154-366 (387) Show / Hide 
Range on Protein: 469-699
Range on HMM: 154-366/387
Sequence Identity: 18% (41 aa)

VSECGWAARRAPHLHTLynICRNMHaWLRQ--DHKNVCVVHCMDGRAASAVAVCSFLCFCrLFSTAEAAVYMFSMKRcpP-GIWPSHKrYIEYMCDMVaE
. ....    || |. |  ... .  .. .  |.|.| .|||. |.  |.. .. .| ..    |.|.|..... ||  |  | |. . ..... |.| .
ylripidDhnapplenl--fekaid-fieegndskgvVlVHCkaGkgRsgtliiaYlmks-egltleealdwvrskR--pgvitpnqg-flkqlkdle-k

EPITPHSKPILVRAVVMTPVPLFSKQrSGCRPFCEVYVGDervastSQEYDKMRDFKIEDGKAV---IPLGVTVQGDVLIVIYHARsTlggrlqAKMASM
...|... .| | .  |. . ..  .. ..  ....       .  .|..   .|.. . |   |  |. ..|||.. ...   .|.    .....|.|.
eklkvssevmelrfvissivqnlgsv-evsvsvlkkvate------kakldrlkiLvideqekvvitikdglplsgDVkvelfkkn-l------dkiird

KMFQIQFHTGFVPRNATTVkfAKYDLDACDIQEKYPD
... .   .   | .||    .. ...          
iilntfFvtnyikdeslvl--vkkeldelhkskifdv
DnaJ GAK.AA DnaJ 1246-1307 22 8.6e-07 29.81 SMART 1-72 (72) Show / Hide 
Range on Protein: 1246-1307
Range on HMM: 1-72/72
Sequence Identity: 22% (16 aa)

ESRWTPVGMADLVAPEQVKKHYRRAVLAVHPDKAAGQPY----------EQHAKMIFMELNDAWSEFENQGS
.  .   |      ....|| ||. .. .||||  | |           ...|.  |.|.| |..   .. .
RDYYEILGVPRDADDDEIKKAYRKLAKKYHPDKNPGDPERSCWKLCWEEKEEAEEKFKEINEAYEVLSDPEK
Phosphatase GAK.AA Subfamily.RNGTT.PD 486-560 24 2.3e-06 16.4 In-house 67-134 (140) Show / Hide 
Range on Protein: 486-560
Range on HMM: 67-134/140
Sequence Identity: 24% (18 aa)

YNICRNmhaWLRQDHKNVCVVHCMDGRAASAVAVCSFLCFCRLFsTAEAAVYMFSMKRcPPGIWPSHkrYIEYMC
.....   .|..  ..|  |||  |       ....|     . . |||| .|.. | ||||. ..  |.. .  
iklvke---flkkkPdevigvhCthGfnrtGflivayLvekedw-sveaavalfakar-ppGiyked--ylkelf
Sequence
Name Sequence Type Origin Length Description Download
GAK.AA Protein None 1311 None Fasta, JSON
GAK.NA RNA None 3933 None Fasta, JSON