Gene DNAJC6
DNAJC6
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of DNAJC6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | DNAJC6.AA | Subfamily.PTEN.PD | 65-220 | 21 | 3.2e-22 | 67.8 | In-house | 1-160 (305) | Show / Hide |
Range on Protein: 65-220 Range on HMM: 1-160/305 Sequence Identity: 21% (34 aa) DFTYVTSRIIVMSFPLDNVDIGFRNQVDDIRSFLDSRHLDHYTVYNLSPK-SYRTAKFHSRVSECSWPIRQAPSLHNLFAVCRNMYNWLLQNPKNVCVVH |..|. . .||.|.| .... ......| .|.... ... ...|. . .. ...|..||.. ..|.|. | ..... .|| ...|| .||| disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavH CLDGRAASSILVGAMFIFCNLYSTPGPAIRLLYAKRPGIG--L-SPSHRRYLGYMCDLLA |. . ... | ... . .... |... || . || |||. | |. CkaGkGRtGvmicayLlksgikksadealaiydekRtkdkkGVtiPSQrRYvqYfsklvk |
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| Phosphatase | DNAJC6.AA | PTEN_C2 | 226-365 | 29 | 3e-43 | 154.78 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 226-365 Range on HMM: 1-141/141 Sequence Identity: 29% (43 aa) PHFKPLTIKSITV-SPIPFFNKQRNGC-RPYCDVLIGETKIYSTCTDFERMKEY-RVQDGKIFIPLNITVQGDVVVSMYHLR-STIGSRLQAKVTNTQIF |..|||....|.. ..||.| ||..|| |||. . ...|...||.... .|.| . .......| ...|||||.. || . |.... . . .| PPPKPLFLHCIIMDHGIPNF-KQGGGCWRPYIQIYQNDQKVFYTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYEEC-----MF QLQFHTGFIPLDTTVLKFTKPELDACDVP---EKYPQLFQVTLDVEL ...|.|.||......|.|.| ||| .. . ...|. |.|.. . RFWFNTCFIEHNNNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE |
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| Phosphatase | DNAJC6.AA | Subfamily.Tensin.PD | 121-360 | 25 | 6.5e-31 | 96.2 | In-house | 1-232 (237) | Show / Hide |
Range on Protein: 121-360 Range on HMM: 1-232/237 Sequence Identity: 25% (62 aa) FHSRVSECSWPIRQAPSLHNLFAVCRNMYNWLLQNPKNVCVVHCLDGRAASSILVGAMFIFCNLYSTPGPAIRL-----LYAKRPGIGLSPSHRRYLGYM ....| . || .||.|. | ..|... || .|.|| |.|| |. .. . | . .. ... |. .| .. .|| |||. |. lnekvldlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyf CDLLADKpYRPHFKPLTIKSITVSPIPFFNKqRNGCRPYCDVLIGETKIYSTCTdFErMKEYRVQDGKIFIPLNITVQGDVVVSMYHLRSTigsrlqaKV .||... . .|| .. . . || |. . ||||. . . .|.. .. . . | | . ..|||.| || . | sgllsgs-iklnssplflhyvilhgipnfds-kggcrpflkiyqalqlvytsgv-yn-vagedterlcitiepalllkgdvlvkcyhkklr-------st TNTQIFQLQFHTGFIplDTTVLKFTKPELDACDVPEKYPQLFQVT . .|..||||| | ..| | | .|| |..|. .| trdvvfrvqfhtgai--kdlklvfekedldealkderfpeyakve |
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| Phosphatase | DNAJC6.AA | Family.DSP.PD | 119-338 | 18 | 1.5e-15 | 45.9 | In-house | 150-351 (387) | Show / Hide |
Range on Protein: 119-338 Range on HMM: 150-351/387 Sequence Identity: 18% (39 aa) AKFHsrVSECSWPIRQAPSLHNLfaVCRnMYNWLLQ--NPKNVCVVHCLDGRAASSILVGAMFIFCNLYSTPgPAIRLLYAKRPgIGLSPSHRrYLGYMC .... . ..... .||.|.|| ... .... . ..|.| .||| |. | |. | ..... .. . |.... ||| . |. . .|.. | lgik--ylripidDhnapplenl--fek-aidfieegndskgvVlVHCkaGkgRsgtliiaYlmksegltle-ealdwvrskRp-gvitpnqg-flkqlk DLLADKpYRPHFKPLTIKSITVSPIPFFNKqRNGCRPYCDVLIGETKIYSTCTDFERMKEYRVQdgkIFIPLNITVQGDVVVSMYHlrstigSRlQAKVT |. | .. ... .. ...| .. . . ... . . .| . . . .| | | . ..||| | .... |. . |.. dlekek-lkvssevmelrfvissivqnlgs-vevsvsvlkkvatekakldrlkiLvideqekvv---itikdglplsgDVkvelfk------kn-ldkii NTQIFQLQFHTGFIPLDTTVLK .|.|..|. . ||. rdiilntfFvtnyikdeslvlv |
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| Phosphatase | DNAJC6.AA | Subfamily.TPIP.PD | 121-267 | 23 | 6.2e-12 | 34.2 | In-house | 1-151 (245) | Show / Hide |
Range on Protein: 121-267 Range on HMM: 1-151/245 Sequence Identity: 23% (33 aa) FHSRVSECSWPIRQAPSLHNLFAVCRNMYNWLLQNPKNVCVVHCLDGRAASSILVGAMFIFCNLYSTPGPAIRLLYAKRPGIGL--------SPSHRRYL || ||| . | |..|. ..... .|| ....|| ..|| |. .| |..| ....| .. . .||| .||.||. .. . | fhnrvsrimiddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryv GYMCDLLadKPYRPHFKPLTIKSITVspIPFFNKQRNGCRPYCDVLIGETKIYST . | | | . .. . . | .|.. . ..|. gylaqvk--hlynwnlpprrilfikr--fiiysirgdvcdlkvqvvmekkvvfss |
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| DnaJ | DNAJC6.AA | DnaJ | 848-909 | 23 | 3.7e-07 | 31.01 | SMART | 1-72 (72) | Show / Hide |
Range on Protein: 848-909 Range on HMM: 1-72/72 Sequence Identity: 23% (17 aa) ETKWKPVGMADLVTPEQVKKVYRKAVLVVHPDKATGQPY----------EQYAKMIFMELNDAWSEFENQGQ .. .. | .....|| ||| .. .|||| .| | .. |. |.|.| |.. .. . RDYYEILGVPRDADDDEIKKAYRKLAKKYHPDKNPGDPERSCWKLCWEEKEEAEEKFKEINEAYEVLSDPEK |
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| Phosphatase | DNAJC6.AA | Subfamily.PTPMT1.PD | 154-210 | 29 | 5.3e-06 | 14.9 | In-house | 83-138 (146) | Show / Hide |
Range on Protein: 154-210 Range on HMM: 83-138/146 Sequence Identity: 29% (17 aa) QNPKNVCVVHCLDGRAASSILVGAmFIFCNLYSTPGPAIRLLYAKRPGIGLSPSHRR .. .. ||| ||. |. ||.. .. . .| |...| .||| | | ...| askgssvYvHCkAGrtRsatlvac-ylmkkkklspeeavkflkkkRpqirlkskqwr |
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