Gene CDKN3
CDKN3
Species: Human
Alias: MGC70625, KAP1, CIP2, CDKN3, FLJ25787, KAP, CDI1
External Links:
COSMIC
,
Entrez Gene
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of CDKN3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| CDKN3 | CDKN3.AA | CDKN3 | 1-207 | 85 | 6.8e-169 | 572.18 | Pfam | 1-207 (207) | Show / Hide |
Range on Protein: 1-207 Range on HMM: 1-207/207 Sequence Identity: 85% (178 aa) MKPPSSIQTSEFDSSDEEPIEDEQTPIHISWLSLSRVNCSQFLGLCALPGCKFKDVRRNVQKDTEELKSCGIQDIFVFCTRGELSKYRVPNLLDLYQQCG ||||.|||||||||||||||.|||||||||||.||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||| MKPPISIQTSEFDSSDEEPIDDEQTPIHISWLPLSRVNCSQFLGLCALPGCKFKDVRRNIQKDTEELKSCGIQDIFVFCTRGELSKYRVPNLLDLYQQCG IITHHHPIADGGTPDIASCCEIMEELTTCLKNYRKTLIHCYGGLGRSCLVAACLLLYLSDTISPEQAIDSLRDLRGSGAIQTIKQYNYLHEFRDKLAAHL ||||||||.||||||||||.||||||||||||||||||||||..||||||||||....||||||||..|..||.|.|||||.|||.|||||..||..||. IITHHHPIPDGGTPDIASCWEIMEELTTCLKNYRKTLIHCYGPWGRSCLVAACLVPHSSDTISPEQTKDMHRDSRTSGAIQKIKQMNYLHEHFDKTTAHK SSRDSQS .|.|.|. QSCDCQE |
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| Phosphatase | CDKN3.AA | Family.DSP.PD | 59-194 | 19 | 9.4e-17 | 52.3 | In-house | 122-242 (387) | Show / Hide |
Range on Protein: 59-194 Range on HMM: 122-242/387 Sequence Identity: 19% (27 aa) NvqKDTEELKSCGIQDIFVFCtrgelskY------RvpnlldlyqQCGIITHHHPIADGGTPDIAS-CCEIMEELTTCLKNYRKTLIHCYGGLGRSCLVA |..|.|| |...| . . . || ...|| |...|.... ..... . .. .. . |.||..|.|||. .. |. a--knlewlkelgvtkivnlt-------ddkpqftk---------elgikylripidDhnapplenlfekaidfieegndskgvVlVHCkaGkgRsgtli ACLLLYLsDTISPEQAIDSLRDLRgsgAIQTIKQYNYLHEFRD . .. |.|.| .|. | ... ....|... | iaYlmks-egltleealdwvrskR---pgvitpnqgflkqlkd |
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| Phosphatase | CDKN3.AA | Subfamily.PTPDC1.PD | 95-195 | 28 | 3.2e-16 | 50.4 | In-house | 129-226 (229) | Show / Hide |
Range on Protein: 95-195 Range on HMM: 129-226/229 Sequence Identity: 28% (28 aa) LYQQCGIITHHHPIADGGTPDIASCCEIMEELTTCLkNYRKTLIHCYGGLGRSCLVAACLLLYlSDTISPEQAIDSLRDLRgSGAIQTIKQYNYLHEFRD ... ||. . ...| |.. . . .|. .. | . |. .||. |||| .. || |.| .. ...|.||. .|. | . .||| .| . ..||. elmrqgiyfynfglkDygvasleriLdivkvvdfal-eegkiavHCHAGlGRtGvliacylvy-akrltaeeaiklvrskr-pksiqtreqvelveeFal K f |
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| Phosphatase | CDKN3.AA | Subfamily.PRL.PD | 94-195 | 27 | 8.7e-11 | 32.8 | In-house | 40-139 (140) | Show / Hide |
Range on Protein: 94-195 Range on HMM: 40-139/140 Sequence Identity: 27% (29 aa) DLYQQCGIITHHHPIADGGTPDIASCCEIMEELTTCLKNYRKTL--IHCYGGLGRSCLVAACLLlyLSDTISPEQAIDSLRDLRgSGAIQtIKQYNYLHE . .. || . . .||..| . | .| | . |. |. .|| ||||. .. | | . . ...|.|.. .|. | ||| || ..|.. eklkeegievldlafddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlvalal--ieaGmkyedavefirekr-rgain-skqlkflek FRDK .. | ykak |
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| Phosphatase | CDKN3.AA | Subfamily.PTPMT1.PD | 89-195 | 25 | 9.3e-11 | 32.7 | In-house | 41-146 (146) | Show / Hide |
Range on Protein: 89-195 Range on HMM: 41-146/146 Sequence Identity: 25% (26 aa) VPNLLDLYQQCGIITHHHPIADGGT-PDIASCCEIMEELTTCLKNYRKTLIHCYGGLGRSCLVAACLLLYlSDTISPEQAIDSLRDLRGSGAIQTiKQYN . | . ... |. . .. | . |. .. | .| . . .. . .|| | .|| ..|| |.. . .|||.|.. |.. |... ||.. |.| lansteewkklGveqlqlatvDfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmk-kkklspeeavkflkkkRpqirlks-kqwr YLHEFRDK |..| alqefkek |
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| Phosphatase | CDKN3.AA | Subfamily.DSP23.PD | 113-193 | 23 | 1.8e-08 | 25.5 | In-house | 46-124 (128) | Show / Hide |
Range on Protein: 113-193 Range on HMM: 46-124/128 Sequence Identity: 23% (19 aa) TPDIASCCEIMEELTTCLKNYRKTLIHCYGGLGRSCLVAACLLLYlSDTISPEQAIDSLRDLRgSGAIQTIKQYNYLHEFR | . .... . |. .|| ||||. . || |. .. .. ..|| .| .| |.|.| .| . ..... PPaleqvarlvriveeaekkeeavgvhcalGlGrtGtllacylvk-eeglaaddaiaevrkrr-kGsietveqekavkdye |
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| Phosphatase | CDKN3.AA | Subfamily.R_Nematode_3.PD | 123-189 | 27 | 1.4e-07 | 22.1 | In-house | 187-258 (267) | Show / Hide |
Range on Protein: 123-189 Range on HMM: 187-258/267 Sequence Identity: 27% (20 aa) MEELTTCLKNYR-KTLIHCYGGLGRS-CLVA---ACLLLYLSD-TISPEQAIDSLRDLRgSGAIQTIKQYNYL . || ..... ..||. | .|| .|.| .. |. |. ... . |..|| | ||||| ... .. alelikfveksktpvvVHCsdGisRsatlaaielgyqliikskgkldllslikelrkqR-agaiqtelelafv |
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| Phosphatase | CDKN3.AA | Subfamily.CDC14.PD | 96-187 | 21 | 2.8e-07 | 21.4 | In-house | 164-251 (258) | Show / Hide |
Range on Protein: 96-187 Range on HMM: 164-251/258 Sequence Identity: 21% (20 aa) YQQCGIITHHHPIADGGTPDIAscceIMEELTTCLKNYR-KTLIHCYGGLGRSCLVAACLLLYLSdTISPEQAIDSLRDLRGSGAIQTIKQYN ... |. . .||..|. | |... .. . . . . .|| |||| . .| |.. .. ...| || | | ..| ftdaGfahlDlffiDGtvPsda----ilkkfleitekaeGaiavhCkaGLGrtgtligcylikhy-rftaaetiawlriarPGsvigpqqtyl |
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| Phosphatase | CDKN3.AA | Subfamily.PTEN.PD | 70-175 | 21 | 2.9e-07 | 21.1 | In-house | 39-136 (305) | Show / Hide |
Range on Protein: 70-175 Range on HMM: 39-136/305 Sequence Identity: 21% (22 aa) CGIQDIFVFCTRGELSKYRVpnlldlyqqcGIITHHHPIADGGTPDIASCCEIMEELTTCLKNYRKT--LIHCYGGLGRSCLVAACLLLYLSDTISPEQA | ... ....||| . . .. |. | | . ||.|.. . ||. .. .|| | ||. .. .. ||.. |...|.. kgkgklrilnargekedsdf----------dgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavHCkaGkGRtGvmicayLlksgikksadea IDSLRDLR . | laiydekR |
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| Phosphatase | CDKN3.AA | Subfamily.DSP3.PD | 59-175 | 23 | 9e-07 | 19.9 | In-house | 15-130 (148) | Show / Hide |
Range on Protein: 59-175 Range on HMM: 15-130/148 Sequence Identity: 23% (28 aa) NVQKDTEELKSCGIQDIFvFCTRGeLSKYRVPNLLDLYQQCGIITHHHPIADGGTPDIASCCEIM-EELTTCLKN-YRKTLIHCYGGLGRSCLVAACLLL .| ||.|.|| || .. ...| . .| . |.. .| . .. | . |. . | . . |.. | |.|| |. ||.. |. . avakdkekLkklGithvL-naaeg-krllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisRsatlvlayLm yLSDTISPEQAIDSLRDLR . ... ..|| |. | -irrkltlkeaiktvrkkr |
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| Phosphatase | CDKN3.AA | Subfamily.N_Nematode_6.PD | 105-191 | 30 | 2.2e-06 | 18.3 | In-house | 159-246 (253) | Show / Hide |
Range on Protein: 105-191 Range on HMM: 159-246/253 Sequence Identity: 30% (27 aa) HHPIADGGTPDiaSCCEIMeELTTCLKNYRK-TLIHCYGGLGRSCLVAACLL----LYLSDTISPEQAIDSLRDLRgSGAIQTIKQYNYLHE . | | || |. . | . .|. .| ..|| |.|| .| | | | | .. .. . ||. | |.||.|| | . WanWPdhGvPd--sflsal-rllsvvkkdkkPivvhCsaGvGrtGtlaliliilealrlpdfqgvkdllvklreer-fravqtevqylyalr |
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| Phosphatase | CDKN3.AA | Subfamily.R_Nematode_2.PD | 110-190 | 28 | 2.2e-06 | 18.1 | In-house | 172-253 (261) | Show / Hide |
Range on Protein: 110-190 Range on HMM: 172-253/261 Sequence Identity: 28% (24 aa) DGGTPDIAscCEIMEELTTCLKNYRKTLIHCYGGLGRSCLVAAC--LL--LYLSDTISPEQAIDSLRDLRGSgAIQTIKQYNYLH | |.|. |. | | |. . ..|| |.||. . . | . .||. ..|.. ||. | .||| .|. .|. drgvPksh--aelfeLlelvkksekPivvhCsaGiGRtmafigteylareveadptieltealkelrehRwk-giqtesqlywlt |
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| Phosphatase | CDKN3.AA | Subfamily.Tensin.PD | 113-198 | 23 | 3.8e-06 | 17.5 | In-house | 15-106 (237) | Show / Hide |
Range on Protein: 113-198 Range on HMM: 15-106/237 Sequence Identity: 23% (22 aa) TPDIASCCEIMEELTTCLKNYRKT--LIHCYGGLGRSCLVAACLLLYLSDTISPEQAIDSLRDLR----GSGAIQTIKQYNYLHEFRDKLAA .| . | |...| . || . .|| || || .| .. . | . . |...|.| . | . ... | |.. | . |.. aPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyfsgllsg |
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| Phosphatase | CDKN3.AA | PTPc_motif | 101-195 | 18 | 4e-06 | 20.14 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 101-195 Range on HMM: 1-92/92 Sequence Identity: 18% (19 aa) II--THHHPIADG-----GTPDIASCCEIMEELTTCLKNYRKTLIHCYGGLGRSCLVAACLLLYLSDTISPEQAIDSLRDLRGSGAIQTIKQYNYLHEFR .. |.. | |.|. . . |. ... ...|| | ||.. ..| ... . .. .| . ..|. | |..|| || .... TVHHYHYTNWPDHVEKDSGVPE-----DSILEFIRHVRK--PIVVHCSAGCGRTGTFCAIDMMMQQ--VDIFQTVKEMRKQR-PGMVQTEEQYIFCYRCI DK . LE |
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| Phosphatase | CDKN3.AA | Subfamily.N_Nematode_1.PD | 109-191 | 23 | 4.9e-06 | 17.0 | In-house | 174-258 (265) | Show / Hide |
Range on Protein: 109-191 Range on HMM: 174-258/265 Sequence Identity: 23% (21 aa) ADGGTPDIASccEIMEELTTCLKNYRKTLIHCYGGLGRSCLVAAclLLYLSDTISPE-------QAIDSLRDLRgSGAIQTIKQYNYLHE | | | . ..| |. .. ...|| |.||. . | . |. | . . . ....|. | . .||| .|| ..| PdrGvPpadl--aalelleavrgskgPivvhCsaGiGrtGtiva--ieyildkllegkqiedmeklvkkireqr-nysiqtdaqylfvhr |
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| Phosphatase | CDKN3.AA | Subfamily.N_Choan_2.PD | 110-191 | 21 | 6.5e-06 | 16.5 | In-house | 172-259 (266) | Show / Hide |
Range on Protein: 110-191 Range on HMM: 172-259/266 Sequence Identity: 21% (19 aa) DGGTPDIASCCEIMEELTTCLKNYRK---TLIHCYGGLGRSCLV----AACLLLYLSDTISPEQAIDSLRDLRGsGAIQTIKQYNYLHE .... . . ...... . |. .| .|.|| |.||. .. |. || . . . . |. || | .|. .||..|.. edsslstdqllkmlravrrvrkeldkaePllvHcsaGvgRtGtliaiDiavrlLeetkkvdvlaiieelRkdRm-alvqhpeqyellyk |
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| Phosphatase | CDKN3.AA | Subfamily.N_Nematode_5.PD | 121-191 | 17 | 9e-06 | 16.0 | In-house | 178-251 (258) | Show / Hide |
Range on Protein: 121-191 Range on HMM: 178-251/258 Sequence Identity: 17% (13 aa) EIMEELTTCLKNYRKTLIHCYGGLGRSCLVAACLLL--YLSDT--ISPEQAIDSLRDLRgSGAIQTIKQYNYLHE .|...| . .. ...... ||||.. ... .. .| . . .. . ..|. | ||.....|| .... aiekvlskkqgknapvvvvsdlGlgRagtflllsvaieqlnngkepnideilkkirsqR-pgavesliqyasvya |
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