Gene DUSP12
DUSP12
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of DUSP12.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | DUSP12.AA | Family.DSP.PD | 24-187 | 28 | 8.7e-29 | 91.9 | In-house | 104-265 (387) | Show / Hide |
Range on Protein: 24-187 Range on HMM: 104-265/387 Sequence Identity: 28% (46 aa) AGQMLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGPGVEdlwRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSV |.. |. |.|| |.. |. . . |.|.|.|... . ..|.|. |.. | .| | ....| ....... || ... .. |||||.||..|| ngkpseilphlylgsllaaknlewlkelgvtkivnltddkpqftkelgik---ylripidDhnapplenlfekaidfieegndskgvVlVHCkaGkgRsg AIITAFLMKTDQLPFEKAYEKLQILKP-EAKMNEGFEWQLKLYQAMGYEVDTSSAIYKQYRLQKV .| |.||| .| .|.|.. ... .| .. |.|| ||| .. . .| .. ...... . | tliiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekeklkvssevmelrfvissiv |
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| Phosphatase | DUSP12.AA | Subfamily.DSP12.PD | 26-169 | 47 | 1.9e-53 | 171.3 | In-house | 1-142 (143) | Show / Hide |
Range on Protein: 26-169 Range on HMM: 1-142/143 Sequence Identity: 47% (69 aa) QMLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEE-PSFKAGPGVEDlwrLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVA .. |..||||.||..||.|...|.|. ||.||.|..|| |.... .||.. .....||.||.|||||||..|.|| .......||||||.|||||||. evseilpglylggleavqerellkelkithvlsvikeelpelqkekgvks---kliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvt IITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQAMG |..|.|||...|..|||..... |.|...|||| .||||...|. iviAYlmkkeklslekAlklvkekkkeiepNegFleQLklfekmk |
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| Phosphatase | DUSP12.AA | Subfamily.DSP19.PD | 27-167 | 41 | 7.1e-34 | 107.5 | In-house | 2-138 (139) | Show / Hide |
Range on Protein: 27-167 Range on HMM: 2-138/139 Sequence Identity: 41% (59 aa) MLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFkagpGVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAII . ||.| ||.| ..|. . |.. .|| .| | . | . .|. . .. ||.|||.|||.|.... || .|| .. .|||||.||||||.... vaevkprlylgsqdvaadkeilkklkitHilnvavgvpnv----fpkdftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvv TAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQA |.|||. .| .|||.||.. .| .| |||| ||| |.| iaylmkdeelslekalekvrearpcikPneGFikqLkeyea |
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| Phosphatase | DUSP12.AA | DSPc | 26-168 | 24 | 2.5e-33 | 117.97 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 26-168 Range on HMM: 1-172/172 Sequence Identity: 24% (42 aa) QMLEVQPGLYFGGAAAVA--EPDHLREAGITAVLTVDSEEP-SFKAG------------PGVEDLWRLFVP-ALD-------KPETDLLSHLDRCVAFIG .. |. |.||.|.. . .|. | . .||.|. | | | .|. . . . .. .| | ..|... .......|| GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH QARAEGRAVLVHCHAGVSRSVAIITAFLMKTDQLPFEKAYEKL-----QILK-PEAKMNEGFEWQLKLYQAM ..|..| ||||| ||.|||.... |.|||..... . ||. . . . | |..| ||.... . DCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
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| Phosphatase | DUSP12.AA | DSPc | 34-168 | 25 | 2.3e-29 | 104.03 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 34-168 Range on HMM: 1-151/151 Sequence Identity: 25% (40 aa) LYFGGAAAVA-EPDHLREAGITAVLTVDSEEPSFKAGPGVE----DLWRLFVP-ALD---------KPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAG ||.|.. .. .|. | . |||.|. . | | . . . .. .| .| ..|.. .......|| ..|..| ||||| || LYLGSYPHHMADPAFLQKHGITHVINCTMECPNN-----WFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAG VSRSVAIITAFLMKTDQLPFEKAYEKL-----QILK-PEAKMNEGFEWQLKLYQAM .|||.... |.|||..... . ||. . . . | | .| || |. . ISRSACLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
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| Phosphatase | DUSP12.AA | Subfamily.DSP15.PD | 27-166 | 35 | 1.6e-28 | 90.2 | In-house | 2-136 (138) | Show / Hide |
Range on Protein: 27-166 Range on HMM: 2-136/138 Sequence Identity: 35% (49 aa) MLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEepsfkAGPGVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAII | .| |||| |. . ..|.| || .|.. . | | .||. | ..| | |..|| .... .. || ..| || .||||| ||.||||... mnkvlpGlyvGnfrdakdkeqleenkithilsihds-----akplledikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlv TAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQ .|..| .| .|.| . .. .. |. | ||. ||. .. vayimtvtelswedalkavkaarsvanPnvGfrrqlqefe |
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| Phosphatase | DUSP12.AA | Subfamily.DSP14.PD | 26-166 | 34 | 1.2e-27 | 87.5 | In-house | 1-136 (138) | Show / Hide |
Range on Protein: 26-166 Range on HMM: 1-136/138 Sequence Identity: 34% (48 aa) QMLEVQPGLYFGgAAAVAEPDHLREAGITAVLTVDSEEPSFKagpgVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAI |. |... || . .||. ....|....||... | |.|. | .||. .. .. ||||..| .|.|. .. | .....| ..|||||||||| ... qlseitesLyls-gaaalkkeklkkkkitlivnvttelpetk----ledvktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAsl ITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQ .|.||| ..| ..||. .. .| . | || || | vlaylmkyeklsLreayklvksaRpiirPnvGFwkqlidyE |
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| Phosphatase | DUSP12.AA | Subfamily.DSP6.PD | 28-165 | 32 | 7.9e-27 | 84.6 | In-house | 3-138 (141) | Show / Hide |
Range on Protein: 28-165 Range on HMM: 3-138/141 Sequence Identity: 32% (45 aa) LEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGpgVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIIT .|. | ||.| | . .. . |.. .| || | |. |.. . ..| . .|. |. ...| ... ..|| .|| . .|||||.|||||||... veilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfee--sgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtl AFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLY |.|||. .| ...||. .. |.. | | ||. . aylmkklalslndaydlvkkkksnisPnfnfmgqlldf |
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| Phosphatase | DUSP12.AA | Subfamily.DSP10.PD | 28-162 | 33 | 7.2e-24 | 75.2 | In-house | 3-135 (141) | Show / Hide |
Range on Protein: 28-162 Range on HMM: 3-135/141 Sequence Identity: 33% (45 aa) LEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGPGVEDLWRlfVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIIT .. | |..| |. | |. ||. || | .. | | . |. | .|. |.....| ... ..|| .|| .| .||||||||.|||.... | ssilpflllGnekdaadkdaldrlgikyvlnvttsvPnffeekglvrykr--ipvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvvi AFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQL ..|| .| ...||. .. .| | .| || ayvmkhlslslseaykfvkekrPiisPnlnfmGql |
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| Phosphatase | DUSP12.AA | Subfamily.DSP1.PD | 29-166 | 33 | 2e-23 | 73.8 | In-house | 4-137 (139) | Show / Hide |
Range on Protein: 29-166 Range on HMM: 4-137/139 Sequence Identity: 33% (46 aa) EVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFkagpgVEDLWR-LFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIIT |. . ||.|.| .. . |.| .|||.| | .| | .|.|.. .| |....|..|... . || .....| |||||.||.||| .|. eildfLyLGsaehasnlqlLkelkitallnvsaelpnv-----feelfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativl AFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQ |.|||.... .|.|.| .. . . | || || .. ayLmkekkvrleeafefvkqrrsiisPnfgfvgqLlefe |
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| Phosphatase | DUSP12.AA | Subfamily.Slingshot.PD | 33-168 | 35 | 3e-23 | 73.1 | In-house | 8-139 (139) | Show / Hide |
Range on Protein: 33-168 Range on HMM: 8-139/139 Sequence Identity: 35% (48 aa) GLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAgpgvEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMK ||.| .. ..|.| |.. .| | | .| . |.. | . |..|||||.| .. || .|...| ||||| ||||| ... |. ||. hlylGsewnasnleelkengveyilnvtkeidnffp----ekfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviayamk TDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQAM .| .|.|.| .. . .| |.|| ||| |. . eyelsleealeyvkerrsiikpnkgflkqlkvyegi |
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| Phosphatase | DUSP12.AA | Subfamily.LRR-DSP.PD | 30-167 | 31 | 5.1e-23 | 72.3 | In-house | 5-136 (137) | Show / Hide |
Range on Protein: 30-167 Range on HMM: 5-136/137 Sequence Identity: 31% (43 aa) VQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFkagPgvEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGrAVLVHCHAGVSRSVAIITAF . ..||.|. . . |.. ..| .|.| .| . | . . | . . | .|.|. |... ||| . | .| ||.|| |||||| ... |. iidklylgcresamnksilkdnnvthilavadfkply---p--dlfkyliidiedvdeadiyqhfkemnafidegrekg-gvlihcragvsrsatlviay LMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQA ||| ..| |..|.. . .|. . |.|| ||| ... lmkknslkfkealdlvikkrpriypnrgfldqlkkfek |
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| Phosphatase | DUSP12.AA | Subfamily.DSP8.PD | 29-165 | 32 | 1.8e-21 | 67.5 | In-house | 4-138 (143) | Show / Hide |
Range on Protein: 29-165 Range on HMM: 4-138/143 Sequence Identity: 32% (44 aa) EVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGpgVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITA .. | ||.| . . . |.. ||. || . .. | ... | .| || | .|| ..|... || .||.. |||||.|| ||| ... | rilpnlylGsqkdsldeellkklgisyvlnisescpkdvel--lkesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaia FLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLY ..||| .. ...||. .. .| . | |. || | yimktlemsldeayrfvkekrptispnlnflgqLley |
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| Phosphatase | DUSP12.AA | Subfamily.STYX.PD | 27-167 | 32 | 2.4e-20 | 63.8 | In-house | 2-145 (146) | Show / Hide |
Range on Protein: 27-167 Range on HMM: 2-145/146 Sequence Identity: 32% (46 aa) MLEVQPGLYFGGAAA--VAEPDHLREAGITAVLTVDSEEPSFKAGPGVEDLWRLFV-PALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSV | |. |||..| .| . ..|.| ||| .. . . . | .| .| .| |.. ... .| . .|| .. .| ||||||.||| |. mqeilpglflgpysaamksklevlkehgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsa AIITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQA . |..|.| | . .|. .| . ..|||| ||| |.| alviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea |
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| Phosphatase | DUSP12.AA | Subfamily.STYXL1.PD | 29-165 | 33 | 4.7e-20 | 63.1 | In-house | 4-140 (143) | Show / Hide |
Range on Protein: 29-165 Range on HMM: 4-140/143 Sequence Identity: 33% (46 aa) EVQPG-LYFGGAAAVAEPDHLREAGITAVLTVDSEEPSF-KAGPGVedLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAII || || || | .| .. . |.. | |. . .. ..| | .. |..|.|||..|.. | ||.. . ||..||| .|.|||.|.| evlPgklylGnykqaqnpaikkdlkvkahvnvssdaekliagladv--akllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaavi TAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLY |.|| .. ..|||..|. |.. | | .| ||. . iaylmyskkitlkkaykylkkckenvkPnrafveqlseW |
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| Phosphatase | DUSP12.AA | Subfamily.DSP3.PD | 28-164 | 32 | 1.7e-19 | 61.1 | In-house | 3-144 (148) | Show / Hide |
Range on Protein: 28-164 Range on HMM: 3-144/148 Sequence Identity: 32% (46 aa) LEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGPGVE-----DLWRLFVPALDKPETDLLSHLDRCVAFIGQARAE-GRAVLVHCHAGVSR || |..| |..|. . ..|.. ||| || .. .| . | .. | |.. | ||.|| .. .. . || .| .. . |||||..|.||| devypkvyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisR SVAIITAFLMKTDQLPFEKAYEKLQIlKPEAKMNEGFEWQLKL ... |.|| . .| ..| .. . | | |||| || satlvlayLmirrkltlkeaiktvrk-kreilPneGflkqLle |
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| Phosphatase | DUSP12.AA | Subfamily.PTPMT1.PD | 77-165 | 29 | 1.2e-15 | 48.5 | In-house | 55-143 (146) | Show / Hide |
Range on Protein: 77-165 Range on HMM: 55-143/146 Sequence Identity: 29% (26 aa) RLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLY | .. | |. | .| . | || . . .| .| ||| || .|| ......|||. .| |.| . |. .|. .... |. . qlqlatvDfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlkskqwralqef |
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| Phosphatase | DUSP12.AA | Subfamily.Laforin.PD | 78-137 | 31 | 1e-07 | 22.7 | In-house | 74-133 (165) | Show / Hide |
Range on Protein: 78-137 Range on HMM: 74-133/165 Sequence Identity: 31% (18 aa) LFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMKTDQLP ...| | . | ..| .. .| | ||| ||| || ||. ||. . iwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgws |
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| Phosphatase | DUSP12.AA | Subfamily.PTPDC1.PD | 99-151 | 31 | 2.2e-07 | 21.4 | In-house | 158-209 (229) | Show / Hide |
Range on Protein: 99-151 Range on HMM: 158-209/229 Sequence Identity: 31% (16 aa) AFIGQARAEGRaVLVHCHAGVSRSVAIITAFLMKTDQLPFEKAYEKLQILKPE . .| ||. . |||||| | .|...|. ...| |.| .... .|. kvvdfaleegk-iavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrpk |
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| Phosphatase | DUSP12.AA | Subfamily.DSP23.PD | 48-142 | 25 | 4.1e-07 | 21.0 | In-house | 9-100 (128) | Show / Hide |
Range on Protein: 48-142 Range on HMM: 9-100/128 Sequence Identity: 25% (24 aa) LREAGITAVLTVDSEEPS-FKAGPGVeDLWRLFVPALDKPETDllsHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMKTDQLPFEKAY | . || .... | .. .| |.. | |. .| | . ..| | . .| ... || ||| |. |. .... .|.|...|..| ladqGirvlvslttegapyseaapsl-tlrridipdfcPPale---qvarlvriveeaekkeeavgvhcalGlGrtGtllacylvkeeglaaddai |
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| Phosphatase | DUSP12.AA | Subfamily.CDC14.PD | 107-151 | 34 | 7.8e-07 | 19.9 | In-house | 198-241 (258) | Show / Hide |
Range on Protein: 107-151 Range on HMM: 198-241/258 Sequence Identity: 34% (15 aa) EGrAVLVHCHAGVSRSVAIITAFLMKTDQLPFEKAYEKLQILKPE || |. |||.||. | ..|...|.|. .. . . |.| .| eG-aiavhCkaGLGrtgtligcylikhyrftaaetiawlriarPG |
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| Phosphatase | DUSP12.AA | Subfamily.PTEN.PD | 108-138 | 37 | 1e-05 | 15.9 | In-house | 94-124 (305) | Show / Hide |
Range on Protein: 108-138 Range on HMM: 94-124/305 Sequence Identity: 37% (11 aa) GRAVLVHCHAGVSRSVAIITAFLMKTDQLPF . | |||.|| |. .|.|.|.|. . . snVvavHCkaGkGRtGvmicayLlksgikks |
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