• Phosphatome.Net

Gene DUSP21

DUSP21
Species: Human
Alias: DUSP21, LMWDSP21, MGC149878
External Links: COSMIC , Entrez Gene
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: DSP
Subfamily: DSP14
Protein domain

Protein domains of DUSP21.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase DUSP21.AA DSPc 21-159 31 1.3e-41 145.5 SMART 1-172 (172) Show / Hide 
Range on Protein: 21-159
Range on HMM: 1-172/172
Sequence Identity: 31% (55 aa)

SFSQITRSLFLSNGVAAN--DKLLLSSNRITAIVNASVEVVNVFF-----------------EGIQYIKVP-VTD-------ARDSRLYDFFDPIADLIH
. |.||  |.|..  ...  .. .|. . ||...|.. |... |.                  ..||. .| . |        . . ....|.  .| ||
GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH

TIDMRQGRTLLHCMAGVSRSASLCLAYLMKYHSMSLLDAHTWT-----KSRR-PIIRPNNGFWEQLINYEFK
.   ..|. | ||.||.||||.|| ||||||..||. ||         |.|| |||.|| .|| ||. .| |
DCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK
Phosphatase DUSP21.AA Subfamily.DSP14.PD 22-159 50 6.5e-63 201.4 In-house 2-138 (138) Show / Hide 
Range on Protein: 22-159
Range on HMM: 2-138/138
Sequence Identity: 50% (70 aa)

FSQITRSLFLSnGVAANDKLLLSSNRITAIVNASVEVVNVFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAYL
.|.||.||.|| |.||..|  |....||.|||...|.... .|.....|..|.|.....|...||..|| |.......|.||.||.|||||||||.||||
lseitesLyls-gaaalkkeklkkkkitlivnvttelpetkledvktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlayl

MKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFK
|||...|| .|....||.|||||||.|||.|||.|| |
mkyeklsLreayklvksaRpiirPnvGFwkqlidyEkk
Phosphatase DUSP21.AA Subfamily.DSP1.PD 23-157 40 7.9e-40 126.6 In-house 3-137 (139) Show / Hide 
Range on Protein: 23-157
Range on HMM: 3-137/139
Sequence Identity: 40% (54 aa)

SQITRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVNVFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAYLM
..|   |.|   . | .. ||.. .|||..| | |. ||| |  .| ..|| | ... .. .|....| |...  ..|| |.|| ||.||||...|||||
veildfLyLGsaehasnlqlLkelkitallnvsaelpnvfeelfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayLm

KYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYE
| . ..| .|....|.|| || || || .||...|
kekkvrleeafefvkqrrsiisPnfgfvgqLlefe
Phosphatase DUSP21.AA DSPc 29-159 33 4.2e-39 137.87 Pfam 1-151 (151) Show / Hide 
Range on Protein: 29-159
Range on HMM: 1-151/151
Sequence Identity: 33% (51 aa)

LFLSNGVAAN-DKLLLSSNRITAIVNASVEVVNVFF---EGIQYIKVP-VTD---------ARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSA
|.|..  ... |. .|. . ||...|.. |. | .|   ....|...| | |          ... ....|. . | |..   ..|. | ||.||.||||
LYLGSYPHHMADPAFLQKHGITHVINCTMECPNNWFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRSA

SLCLAYLMKYHSMSLLDAHTWT-----KSRR-PIIRPNNGFWEQLINYEFK
.||.||||||. ||. .|         |.|| |.|.|| .|| ||. ||..
CLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ
Phosphatase DUSP21.AA Subfamily.DSP19.PD 23-157 38 6.5e-38 120.2 In-house 3-137 (139) Show / Hide 
Range on Protein: 23-157
Range on HMM: 3-137/139
Sequence Identity: 38% (52 aa)

SQITRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVNVFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAYLM
....  |.|.   .|.||  |....|| |.| .|.| ||| . ..| .... |  . .| .... . | |.    ..|| |.|| ||||||||. .||||
aevkprlylgsqdvaadkeilkklkitHilnvavgvpnvfpkdftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylm

KYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYE
| ...|| .|    .. || |.||.||..|| .||
kdeelslekalekvrearpcikPneGFikqLkeye
Phosphatase DUSP21.AA Family.DSP.PD 21-169 32 1.7e-34 110.2 In-house 106-256 (387) Show / Hide 
Range on Protein: 21-169
Range on HMM: 106-256/387
Sequence Identity: 32% (49 aa)

SFSQITRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVNVFF-EGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLA
.|.|. .|.| .  ||...  |. ...|.|||.. .  .  . .||.|...|. |   . |  .|. . | |.. .. .|. | ||.||..||..|. ||
kpseilphlylgsllaaknlewlkelgvtkivnltddkpqftkelgikylripidDhnapplenlfekaidfieegndskgvVlVHCkaGkgRsgtliia

YLMKYHSMSLLDAHTWTKSRRP-IIRPNNGFWEQLINYEFKLFNNNTVRMI
|||.. ..| .| .| .|.|| .|.||.||..||  .| .. . ..  |. 
YlmksegltleealdwvrskRpgvitpnqgflkqlkdlekeklkvssevme
Phosphatase DUSP21.AA Subfamily.DSP10.PD 23-157 37 3e-34 108.4 In-house 3-139 (141) Show / Hide 
Range on Protein: 23-157
Range on HMM: 3-139/141
Sequence Identity: 37% (52 aa)

SQITRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVNVFFE--GIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAY
|.|   |.| |.  |.|| .|.   |. ..|   .| | | |   ..| ..||.|.    |   |.   . |. .  |..| |.||.||.|||| . .||
ssilpflllGnekdaadkdaldrlgikyvlnvttsvPnffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvviay

LMKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYE
.||. |.|| .|. . |..|||| || .|  ||...|
vmkhlslslseaykfvkekrPiisPnlnfmGqllefe
Phosphatase DUSP21.AA Subfamily.Slingshot.PD 23-157 35 4.1e-33 104.7 In-house 3-137 (139) Show / Hide 
Range on Protein: 23-157
Range on HMM: 3-137/139
Sequence Identity: 35% (48 aa)

SQITRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVNVFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAYLM
|.|   |.|     | .   |. |... |.| . |. | | | ..|... | |  .. |.....   . |...  .. . |.||  |||||||  .|| |
skifdhlylGsewnasnleelkengveyilnvtkeidnffpekfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviayam

KYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYE
| ...|| .|... |.|| ||.||.||..||  ||
keyelsleealeyvkerrsiikpnkgflkqlkvye
Phosphatase DUSP21.AA Subfamily.DSP8.PD 23-159 32 1.8e-32 102.8 In-house 3-141 (143) Show / Hide 
Range on Protein: 23-159
Range on HMM: 3-141/143
Sequence Identity: 32% (45 aa)

SQITRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVN--VFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAY
.|.. |.|   . . |. ||. . |. ..|.| .      . .  .....|| |  . .| ..||   . |  .   .|. |.||.|| ||||.. .||.
trilpnlylGsqkdsldeellkklgisyvlnisescpkdvellkesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaiay

LMKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFK
||. .||| .|... |..|| | ||  | .||..|| . 
imktlemsldeayrfvkekrptispnlnflgqLleyeke
Phosphatase DUSP21.AA Subfamily.DSP15.PD 22-157 33 5.7e-30 94.6 In-house 2-136 (138) Show / Hide 
Range on Protein: 22-157
Range on HMM: 2-136/138
Sequence Identity: 33% (46 aa)

FSQITRSLFLSNGVAANDKLLLSSNRITAIVNAsVEVVNVFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAYL
.... . |.. |   |.|| .|. |.|| |.    .  . ..|.|.|  ....|. |  |  ||.   |.||.  ...|  |.||.||.||| .|. ||.
mnkvlpGlyvGnfrdakdkeqleenkithilsi-hdsakplledikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayi

MKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYE
|   ..|  || .  |. |..  || || .|| ..|
mtvtelswedalkavkaarsvanPnvGfrrqlqefe
Phosphatase DUSP21.AA Subfamily.DSP6.PD 24-157 32 2.7e-29 92.2 In-house 4-139 (141) Show / Hide 
Range on Protein: 24-157
Range on HMM: 4-139/141
Sequence Identity: 32% (44 aa)

QITRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVNVFFE--GIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAYL
.|.  |.| .  .|..  .|.  .|  ..| . .. |.| |   ..| ..|..|     |  ||    ..|     ..   |.||.||||||...|||||
eilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtlayl

MKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYE
|....|| ||. . |.... | ||  | .||...| 
mkklalslndaydlvkkkksnisPnfnfmgqlldfe
Phosphatase DUSP21.AA Subfamily.DSP3.PD 24-157 30 6.8e-29 91.2 In-house 4-146 (148) Show / Hide 
Range on Protein: 24-157
Range on HMM: 4-146/148
Sequence Identity: 30% (44 aa)

QITRSLFLSNGVAANDKLLLSSNRITAIVNASVE-------VVNVFFEG--IQYIKVPVTDARDSRLYDFFDPIADLIH-TIDMRQGRTLLHCMAGVSRS
...  .....  .|.||  |    || ..||. .         . |...  |.|. |.|.|. .. |  .|.  || |. ... ..|. |.||..|.|||
evypkvyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisRs

ASLCLAYLMKYHSMSLLDAHTWTKSRRPIiRPNNGFWEQLINYE
| | ||||| .....| .| .  ...| |  ||.|| .||....
atlvlayLmirrkltlkeaiktvrkkrei-lPneGflkqLleld
Phosphatase DUSP21.AA Subfamily.DSP12.PD 23-157 30 1.2e-27 87.3 In-house 3-139 (143) Show / Hide 
Range on Protein: 23-157
Range on HMM: 3-139/143
Sequence Identity: 30% (42 aa)

SQITRSLFLSNGVAANDKLLLSSNRITAIVNASVEVVNVFFEGIQYIK--VPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAY
|.|.  |.|..  |.... ||..  ||...    | .. . .  ....  ....|  .  | ...| . . |.    ..|  | ||.||||||.....||
seilpglylggleavqerellkelkithvlsvikeelpelqkekgvkskliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiviAY

LMKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYE
|||.. .|| .|..  |. .. |.||.|| |||  .|
lmkkeklslekAlklvkekkkeiepNegFleQLklfe
Phosphatase DUSP21.AA Subfamily.LRR-DSP.PD 24-158 32 3.9e-27 85.3 In-house 4-136 (137) Show / Hide 
Range on Protein: 24-158
Range on HMM: 4-136/137
Sequence Identity: 32% (44 aa)

QITRSLFLSNGVAANDKLLLSSNRITAIvNASVEVVNVFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTiDMRQGRTLLHCMAGVSRSASLCLAYLMK
.|   |.|    .|..| .| .| .| |  |  ..  .. . ..|. . . |. .  .|..|. .  .|.    ..|  |.|| |||||||.| .|||||
liidklylgcresamnksilkdnnvthi-lavadfkplypdlfkyliidiedvdeadiyqhfkemnafide-grekggvlihcragvsrsatlviaylmk

YHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEF
..|. . .|   ....|| |.||.|| .||  .| 
knslkfkealdlvikkrpriypnrgfldqlkkfek
Phosphatase DUSP21.AA Subfamily.STYX.PD 44-157 29 4.8e-18 56.0 In-house 26-144 (146) Show / Hide 
Range on Protein: 44-157
Range on HMM: 26-144/146
Sequence Identity: 29% (34 aa)

SSNRITAIVN----ASVEVV-NVFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAYLMKYHSMSLLDAHTWTKS
.. || ||        ...   | . ..|. . |.|.    .  ..  . ..| .   . |. |.|  ||.||||.| .||.|. . ..|... . ||  
kehgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqe

RRPIIRPNNGFWEQLINYE
| ||.|| .|| .||    
rrfcinpnegfvsqlkeye
Phosphatase DUSP21.AA Subfamily.STYXL1.PD 27-157 24 1.7e-17 54.5 In-house 8-141 (143) Show / Hide 
Range on Protein: 27-157
Range on HMM: 8-141/143
Sequence Identity: 24% (32 aa)

RSLFLSNGVAANDKLLLSSNRITAIVNASVE---VVNVFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAYLMK
|.| |   | .. .    .. | || | .   ...   .  . ....| |  .. | .... . ..|..   ..   |.    |.||||.. .|||| ..
gklylGnykqaqnpaikkdlkvkahvnvssdaekliagladvakllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaaviiaylmy

YHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYE
 ..| .|..  |  .. ..|| .| ||| ..|  
skkitlkkaykylkkckenvkPnrafveqlseWe
Phosphatase DUSP21.AA Subfamily.PTPMT1.PD 63-157 25 1.7e-15 47.7 In-house 50-144 (146) Show / Hide 
Range on Protein: 63-157
Range on HMM: 50-144/146
Sequence Identity: 25% (24 aa)

FEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRTLLHCMAGVSRSASLCLAYLMKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYE
.|.........|  ..   .      ..|...  .. .  .|| || .|||.|  .|||| . .|  .|..  |..||.|| ..  |.| ...  
klGveqlqlatvDfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlkskqwralqefk
Phosphatase DUSP21.AA Subfamily.CDC14.PD 91-141 26 7.4e-09 26.1 In-house 190-240 (258) Show / Hide 
Range on Protein: 91-141
Range on HMM: 190-240/258
Sequence Identity: 26% (13 aa)

LIHTIDMRQGRTLLHCMAGVSRSASLCLAYLMKYHSMSLLDAHTWTKSRRP
.. ..  .|   .|| ||. | ..|  .||.|.. ..  .. .| .  || 
fleitekaeGaiavhCkaGLGrtgtligcylikhyrftaaetiawlriarP
Phosphatase DUSP21.AA Subfamily.Laforin.PD 64-143 27 1.3e-08 25.2 In-house 69-148 (165) Show / Hide 
Range on Protein: 64-143
Range on HMM: 69-148/165
Sequence Identity: 27% (22 aa)

EGIQYIKVPVTDA-RDSRLYDFFDPiADLIHTIDMRQGRTLLHCMAGVSRSASLCLAYLMKYHSMSLLDAHTWTKSRRPII
||. || .|. |   .||.  . .    |.|..  .  .  .|| ||| ||...   .|.     ||        ..||..
eglayiwlptedlstesrvenlpqa-vyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv
Phosphatase DUSP21.AA Subfamily.PTPDC1.PD 92-141 26 3.5e-06 17.1 In-house 159-208 (229) Show / Hide 
Range on Protein: 92-141
Range on HMM: 159-208/229
Sequence Identity: 26% (13 aa)

IHTIDMRQGRTLLHCMAGVSRSASLCLAYLMKYHSMSLLDAHTWTKSRRP
. .  ...|.. .|| ||  |  .|  .||.  . ..  .| .  .|.||
vvdfaleegkiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrp
Phosphatase DUSP21.AA Subfamily.R_Nematode_3.PD 87-119 30 9.3e-06 15.7 In-house 186-218 (267) Show / Hide 
Range on Protein: 87-119
Range on HMM: 186-218/267
Sequence Identity: 30% (10 aa)

PIADLIHTIDMRQGRTLLHCMAGVSRSASLCLA
.. .||. .   .   . ||..|.||||.|  .
ealelikfveksktpvvVHCsdGisRsatlaai
Sequence
Name Sequence Type Origin Length Description Download
DUSP21.AA Protein None 190 None Fasta, JSON
DUSP21.NA RNA None 570 None Fasta, JSON
DUSP21.AA.PD_21-159 Protein Phosphatase Domain None 139 None Fasta, JSON