• Phosphatome.Net

Gene DUSP18

DUSP18
Species: Human
Alias: LMWDSP20, MGC32658, bK963H5.1, DUSP18, DUSP20, DSP18
External Links: COSMIC , Entrez Gene
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: DSP
Subfamily: DSP14
Protein domain

Protein domains of DUSP18.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase DUSP18.AA Family.DSP.PD 16-181 28 9.1e-36 115.0 In-house 103-272 (387) Show / Hide 
Range on Protein: 16-181
Range on HMM: 103-272/387
Sequence Identity: 28% (48 aa)

SVSGLSQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNTLY-EDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAAL
.. |.|...||. .  ||.|.  |. ...|...|.. .  .  . ..|.|...|. |.. . |  .|. . | |.......|. | || ||..||. |. 
engkpseilphlylgsllaaknlewlkelgvtkivnltddkpqftkelgikylripidDhnapplenlfekaidfieegndskgvVlVHCkaGkgRsgtl

CLAYLMKYHAMSLLDAHTWTKSCRP-IIRPNSGFWEQLIHYEFQLFGKNTVHMVSS--PVGMIPDIYEKE
|||||.. ..| .| .| .|.|| .|.||.||..|| ..| ..   ..  |.     . ..... ..|  
iiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekeklkvssevmelrfvissivqnlgsve
Phosphatase DUSP18.AA Subfamily.DSP14.PD 20-157 52 5.6e-65 208.7 In-house 2-138 (138) Show / Hide 
Range on Protein: 20-157
Range on HMM: 2-138/138
Sequence Identity: 52% (72 aa)

LSQITKSLYISnGVAANNKLMLSSNQITMVINVSVEVVNTLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYL
||.||.|||.| |.||..| .|....||...||..|...| .||.......|.|.|...|...||..||.|..|..|.|.||.||.|||||||.|.||||
lseitesLyls-gaaalkkeklkkkkitlivnvttelpetkledvktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlayl

MKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQ
|||...|| .|....||.|||||||.|||.|||.|| .
mkyeklsLreayklvksaRpiirPnvGFwkqlidyEkk
Phosphatase DUSP18.AA DSPc 19-157 34 6e-45 156.57 SMART 1-172 (172) Show / Hide 
Range on Protein: 19-157
Range on HMM: 1-172/172
Sequence Identity: 34% (59 aa)

GLSQITKSLYISNGVAAN--NKLMLSSNQITMVINVSVEVVNTLY-----------------EDIQYMQVP-VAD-------SPNSRLCDFFDPIADHIH
| |.||. ||...  ...  |. .|. ..|| ||||. |......                  ..|||..| . |       .. . ....|.  .| ||
GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH

SVEMKQGRTLLHCAAGVSRSAALCLAYLMKYHAMSLLDAHTWT-----KSCR-PIIRPNSGFWEQLIHYEFQ
... |.|. | ||.||.||||.|| ||||||. ||. ||         |. | |||.|| .|| ||. .| .
DCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK
Phosphatase DUSP18.AA DSPc 27-157 34 1e-40 143.5 Pfam 1-151 (151) Show / Hide 
Range on Protein: 27-157
Range on HMM: 1-151/151
Sequence Identity: 34% (53 aa)

LYISNGVAAN-NKLMLSSNQITMVINVSVEVVNTLYE----DIQYMQVP-VAD---------SPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRS
||...  ... .. .|. ..|| |||.. |. |. ..    ...||..| | |         .... ....|. . | |.... |.|. | ||.||.|||
LYLGSYPHHMADPAFLQKHGITHVINCTMECPNN-WFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRS

AALCLAYLMKYHAMSLLDAHTWT-----KSCR-PIIRPNSGFWEQLIHYEFQ
|.||.||||||. ||. .|         |. | |.|.|| .|| ||. ||.|
ACLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ
Phosphatase DUSP18.AA Subfamily.DSP1.PD 21-156 40 1.2e-40 129.9 In-house 3-138 (139) Show / Hide 
Range on Protein: 21-156
Range on HMM: 3-138/139
Sequence Identity: 40% (54 aa)

SQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNTLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLM
..|   ||.   . | |. .|.. .|| ..||| |. |.  |  .|...|| |.... .  .|....|.|.||. |.|| |.||.||.||||...|||||
veildfLyLGsaehasnlqlLkelkitallnvsaelpnvfeelfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayLm

KYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEF
| . ..| .|....|. | || || || .||...| 
kekkvrleeafefvkqrrsiisPnfgfvgqLlefek
Phosphatase DUSP18.AA Subfamily.DSP19.PD 21-155 37 2.4e-39 125.5 In-house 3-137 (139) Show / Hide 
Range on Protein: 21-155
Range on HMM: 3-137/139
Sequence Identity: 37% (51 aa)

SQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNTLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLM
..... ||..   .|..| .|....|| ..||.|.| |.  .|..|..... | |. .|..... . | |...  |.|| |.|| |||||||.. .||||
aevkprlylgsqdvaadkeilkklkitHilnvavgvpnvfpkdftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylm

KYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYE
| . .|| .|    .. || |.||.||..|| .||
kdeelslekalekvrearpcikPneGFikqLkeye
Phosphatase DUSP18.AA Subfamily.DSP10.PD 21-155 35 6.4e-36 114.4 In-house 3-139 (141) Show / Hide 
Range on Protein: 21-155
Range on HMM: 3-139/141
Sequence Identity: 35% (49 aa)

SQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNTLY--EDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAY
|.|   |.. |.  |..| .|.  .|..|.||  .| |. .  ....|...|| ||..  |   |.   ..|. .  ...| |.|| ||.||||.. .||
ssilpflllGnekdaadkdaldrlgikyvlnvttsvPnffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvviay

LMKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYE
.||.  .|| .|. . |. |||| || .|  ||...|
vmkhlslslseaykfvkekrPiisPnlnfmGqllefe
Phosphatase DUSP18.AA Subfamily.DSP8.PD 20-157 32 4.6e-34 108.5 In-house 2-141 (143) Show / Hide 
Range on Protein: 20-157
Range on HMM: 2-141/143
Sequence Identity: 32% (45 aa)

LSQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVN--TLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLA
. .|.. ||.   . . .. .|. ..|..|.|.| .     .| .. .....|| |. . .| ..||   . |  .. ..|. |.|| || ||||.. .|
ptrilpnlylGsqkdsldeellkklgisyvlnisescpkdvellkesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaia

YLMKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQ
|.||.  ||| .|... |. || | ||  | .||..|| .
yimktlemsldeayrfvkekrptispnlnflgqLleyeke
Phosphatase DUSP18.AA Subfamily.DSP15.PD 19-155 36 6e-34 108.1 In-house 1-136 (138) Show / Hide 
Range on Protein: 19-155
Range on HMM: 1-136/138
Sequence Identity: 36% (50 aa)

GLSQITKSLYISNGVAANNKLMLSSNQITMVINVSvEVVNTLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAY
|.... . ||. |   |..|  |. |.|| .. .  .  . |.|||.|. ...||||.  |  ||.   | ||.. ...|  |.||.||.||| .|. ||
gmnkvlpGlyvGnfrdakdkeqleenkithilsih-dsakplledikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvay

LMKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYE
.|    .|  || .  |..|..  || || .|| ..|
imtvtelswedalkavkaarsvanPnvGfrrqlqefe
Phosphatase DUSP18.AA Subfamily.Slingshot.PD 21-155 34 9.5e-33 104.1 In-house 3-137 (139) Show / Hide 
Range on Protein: 21-155
Range on HMM: 3-137/139
Sequence Identity: 34% (47 aa)

SQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNTLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLM
|.| . ||.     | |   |. |... ..||. |. |   |...|... | |.... | ....   ..|. .  |. . |.||  ||||||.  .|| |
skifdhlylGsewnasnleelkengveyilnvtkeidnffpekfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviayam

KYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYE
| . .|| .|... |. | ||.||.||..||  ||
keyelsleealeyvkerrsiikpnkgflkqlkvye
Phosphatase DUSP18.AA Subfamily.DSP12.PD 21-155 33 7.8e-32 101.4 In-house 3-139 (143) Show / Hide 
Range on Protein: 21-155
Range on HMM: 3-139/143
Sequence Identity: 33% (46 aa)

SQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNTLYEDIQYMQ--VPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAY
|.|.. ||...  |.... .|.. .|| |. |  | ...| .. ....  ....|.|.  | ...| . ..|..   |.|  | ||.||||||.....||
seilpglylggleavqerellkelkithvlsvikeelpelqkekgvkskliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiviAY

LMKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYE
|||.. .|| .|..  |. .. |.||.|| |||  .|
lmkkeklslekAlklvkekkkeiepNegFleQLklfe
Phosphatase DUSP18.AA Subfamily.DSP3.PD 22-155 32 7.4e-31 98.1 In-house 4-146 (148) Show / Hide 
Range on Protein: 22-155
Range on HMM: 4-146/148
Sequence Identity: 32% (47 aa)

QITKSLYISNGVAANNKLMLSSNQITMVINVSVE-------VVNTLYED--IQYMQVPVADSPNSRLCDFFDPIADHIHS-VEMKQGRTLLHCAAGVSRS
.... .|...  .|..|  |    || |.| . .         .  |.|  |.|. |.| |.|.. |  .|.  || |.. .. |.|. |.||..|.|||
evypkvyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisRs

AALCLAYLMKYHAMSLLDAHTWTKSCRPiIRPNSGFWEQLIHYE
|.| ||||| .. ..| .| .  .. |  | ||.|| .||....
atlvlayLmirrkltlkeaiktvrkkre-ilPneGflkqLleld
Phosphatase DUSP18.AA Subfamily.DSP6.PD 22-155 35 2.8e-30 95.9 In-house 4-139 (141) Show / Hide 
Range on Protein: 22-155
Range on HMM: 4-139/141
Sequence Identity: 35% (48 aa)

QITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNTLY--EDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYL
.|.. ||. .  .|.|  .|.  .|  |.||. .. |.    ....|.|.|. |  .  |  ||    . |     |.   |.|| ||||||...|||||
eilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtlayl

MKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYE
|..|.|| ||. . |. .. | ||  | .||...| 
mkklalslndaydlvkkkksnisPnfnfmgqlldfe
Phosphatase DUSP18.AA Subfamily.LRR-DSP.PD 22-155 33 6.6e-27 85.1 In-house 4-135 (137) Show / Hide 
Range on Protein: 22-155
Range on HMM: 4-135/137
Sequence Identity: 33% (45 aa)

QITKSLYISNGVAANNKLMLSSNQITMVinVSVEVVNTLYEDI-QYMQVPVADSPNSRLCDFFDPIADHIHSVEmKQGRTLLHCAAGVSRSAALCLAYLM
.| . ||.    .|.|| .| .|..| .  ..|  .. || |. .|. . . | ..  . ..|. .   |..   ..|  |.|| |||||||.| .||||
liidklylgcresamnksilkdnnvthi--lavadfkplypdlfkyliidiedvdeadiyqhfkemnafidegr-ekggvlihcragvsrsatlviaylm

KYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYE
|.. . . .|   ... || |.|| || .|| ..|
kknslkfkealdlvikkrpriypnrgfldqlkkfe
Phosphatase DUSP18.AA Subfamily.STYXL1.PD 25-155 26 3.4e-22 70.3 In-house 8-141 (143) Show / Hide 
Range on Protein: 25-155
Range on HMM: 8-141/143
Sequence Identity: 26% (35 aa)

KSLYISNGVAANNKLMLSSNQITMVINVSVE---VVNTLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMK
. ||. |   | |. .    ..  ..||| .   ....| .  . ....| |.... | .... . . |.. . ..   |.    |.|||||. .|||| 
gklylGnykqaqnpaikkdlkvkahvnvssdaekliagladvakllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaaviiaylmy

YHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYE
.. ..| .|..  | |.. ..|| .| ||| ..|
skkitlkkaykylkkckenvkPnrafveqlseWe
Phosphatase DUSP18.AA Subfamily.STYX.PD 37-155 29 9.2e-20 62.1 In-house 20-144 (146) Show / Hide 
Range on Protein: 37-155
Range on HMM: 20-144/146
Sequence Identity: 29% (36 aa)

NKL-MLSSNQITMVINVS----VEVVN-TLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMKYHAMSLLDA
|| .| .. || .. .      ....  . ....|. . |||..   .  ..  . . | .   | |. |.|  ||.|||||| .||.|.. .   .|..
sklevlkehgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyrea

HTWTKSCRPIIRPNSGFWEQLIHYE
. .  |  | ||.|| .|| .||  
fayvqerrfcinpnegfvsqlkeye
Phosphatase DUSP18.AA Subfamily.PTPMT1.PD 63-155 29 3.7e-15 47.1 In-house 52-144 (146) Show / Hide 
Range on Protein: 63-155
Range on HMM: 52-144/146
Sequence Identity: 29% (27 aa)

DIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYE
....|... |  ..   .      . |..|  |. .  .|| || .|||.|  .|||| . .|  .|..  |..||.|| .|  |. |...  
GveqlqlatvDfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlkskqwralqefk
Phosphatase DUSP18.AA Subfamily.CDC14.PD 89-139 28 9.4e-10 29.7 In-house 190-240 (258) Show / Hide 
Range on Protein: 89-139
Range on HMM: 190-240/258
Sequence Identity: 28% (14 aa)

HIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMKYHAMSLLDAHTWTKSCRP
.. .|  .|   .|| ||. | ..|  .||.|.. ..  .. .| . .|| 
fleitekaeGaiavhCkaGLGrtgtligcylikhyrftaaetiawlriarP
Phosphatase DUSP18.AA Subfamily.Laforin.PD 57-140 27 3.5e-07 21.2 In-house 62-147 (165) Show / Hide 
Range on Protein: 57-140
Range on HMM: 62-147/165
Sequence Identity: 27% (24 aa)

VNTLY--EDIQYMQVPVAD-SPNSRLCDFFDPIaDHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMKYHAMSLLDAHTWTKSCRPI
.  ||  | . |. .|. | | .||.  . . .   .|..  |  .  .|| ||| ||.|.   .|.     ||        . ||.
lkklykeeglayiwlptedlstesrvenlpqav-yllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpv
Phosphatase DUSP18.AA Subfamily.N23.PD 39-118 23 7e-06 16.4 In-house 224-302 (350) Show / Hide 
Range on Protein: 39-118
Range on HMM: 224-302/350
Sequence Identity: 23% (20 aa)

LMLSSNQITMVINVSVeVvntlyEDIQYMQVPVADSPNsRLCDFFDPIADHI---HSVEM---KQGRTLLHCAAGVSRSAALCLAY
| |. |.  .| .|.  .     .  .. .. | .||.  | .|.. .  .    . .|.    .   .||| ||| |. ..|. |
lhlqhndvstvrlvch-l-----htttWseiGvPksPe-dllaflgevetayaqqrktetegeggkPiilhCsaGvgRtgtfcvvy
Sequence
Name Sequence Type Origin Length Description Download
DUSP18.AA Protein None 188 None Fasta, JSON
DUSP18.NA RNA None 564 None Fasta, JSON
DUSP18.AA.PD_19-157 Protein Phosphatase Domain None 139 None Fasta, JSON