Gene DUSP28
DUSP28
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of DUSP28.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | DUSP28.AA | DSPc | 18-156 | 23 | 2.4e-38 | 134.62 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 18-156 Range on HMM: 1-172/172 Sequence Identity: 23% (41 aa) PLVRVAPSLFLGSARAAG--AEEQLARAGVTLCVNVSRQQP----GPRA-------------PGVAELRVPVFDD--------PAEDLLAHLEPTCAAME . ... | |.|||.... ..|. ..|...||.. .| ... .. ...|. || . ........ . . .. GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH AAVRAGGACLVYCKNGRSRSAAVCTAYLMRHRGLSLAKAFQMV-----KSAR-PVAEPNPGFWSQLQKYEEA .. . || .||.|. | ||||..| ||||. ...|. |. .| |..| | || .|| ||. .| DCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
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| Phosphatase | DUSP28.AA | Subfamily.DSP14.PD | 19-155 | 39 | 2.2e-52 | 167.1 | In-house | 2-137 (138) | Show / Hide |
Range on Protein: 19-155 Range on HMM: 2-137/138 Sequence Identity: 39% (54 aa) LVRVAPSLFLGsARAAGAEEQLARAGVTLCVNVSRQQPGPRAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYL |.....||.|. ..|| ..|.|.....||.|||....| .....|......| |.|...| .|........|.. ..||..||.|..|.||||....||| lseitesLyls-gaaalkkeklkkkkitlivnvttelpetkledvktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlayl MRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEE |... |||..|...||||||. .||.|||.||..||. mkyeklsLreayklvksaRpiirPnvGFwkqlidyEk |
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| Phosphatase | DUSP28.AA | DSPc | 26-156 | 27 | 4.9e-36 | 127.21 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 26-156 Range on HMM: 1-151/151 Sequence Identity: 27% (42 aa) LFLGSARAAG-AEEQLARAGVTLCVNVSRQQPGPRA---PGVAELRVP-VFD---------DPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSA |.|||. .. ...|. |.|. .|... | ... .. ...| | | . ... .... . .... . || .||.|. | |||| LYLGSYPHHMADPAFLQKHGITHVINCTMECPNNWFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRSA AVCTAYLMRHRGLSLAKAFQMV-----KSAR-PVAEPNPGFWSQLQKYEEA ..| ||||. |..|. |. .| |. | |. ||..|| ||. || CLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
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| Phosphatase | DUSP28.AA | Subfamily.DSP12.PD | 20-156 | 34 | 3.7e-35 | 111.4 | In-house | 3-141 (143) | Show / Hide |
Range on Protein: 20-156 Range on HMM: 3-141/143 Sequence Identity: 34% (48 aa) VRVAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQP--GPRAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAY ... | |.||...|. .|.|. . .| . | ... .|| .. ....|.| |||| ||. ... .| .. .|| || |. | |||.....|| seilpglylggleavqerellkelkithvlsvikeelpelqkekgvkskliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiviAY LMRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEA ||....||| ||...||.... .||| || .||. .|. lmkkeklslekAlklvkekkkeiepNegFleQLklfekm |
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| Phosphatase | DUSP28.AA | Subfamily.DSP19.PD | 20-155 | 37 | 7.3e-35 | 110.2 | In-house | 3-138 (139) | Show / Hide |
Range on Protein: 20-155 Range on HMM: 3-138/139 Sequence Identity: 37% (51 aa) VRVAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPGPRAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLM ..| | |.||| .| ..|.| . ..| .||. . | . . . ....|.| ..||..|. .. .| | ...|. || |. |.||||.| |||| aevkprlylgsqdvaadkeilkklkitHilnvavgvpnvfpkdftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylm RHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEE ... ||| ||...|..||| ..|| ||. ||..||. kdeelslekalekvrearpcikPneGFikqLkeyea |
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| Phosphatase | DUSP28.AA | Family.DSP.PD | 19-161 | 36 | 5.3e-33 | 105.1 | In-house | 107-251 (387) | Show / Hide |
Range on Protein: 19-161 Range on HMM: 107-251/387 Sequence Identity: 36% (53 aa) LVRVAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPGPRA-PGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAY ... |.|.|||..|| .|.|...||| ||.. ..| |.. ||.|. | .|..| ..| . .| . ...| || || |..||. .. ||| pseilphlylgsllaaknlewlkelgvtkivnltddkpqftkelgikylripidDhnapplenlfekaidfieegndskgvVlVHCkaGkgRsgtliiaY LMRHRGLSLAKAFQMVKSARP-VAEPNPGFWSQLQKYEEALQAQS | ..||.| .|...|.|.|| |. || ||..||...|. . .| lmksegltleealdwvrskRpgvitpnqgflkqlkdlekeklkvs |
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| Phosphatase | DUSP28.AA | Subfamily.DSP1.PD | 20-155 | 33 | 1.9e-32 | 102.5 | In-house | 3-138 (139) | Show / Hide |
Range on Protein: 20-155 Range on HMM: 3-138/139 Sequence Identity: 33% (45 aa) VRVAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPGPRAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLM |.. . |.|||| |. ..|.. ..| .|||.. | . ..|| |.. .|.....|. .... ..|| ||.|. | ||||... |||| veildfLyLGsaehasnlqlLkelkitallnvsaelpnvfeelfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayLm RHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEE ... ..| .||. ||. | . .|| || || ..|. kekkvrleeafefvkqrrsiisPnfgfvgqLlefek |
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| Phosphatase | DUSP28.AA | Subfamily.DSP10.PD | 18-155 | 34 | 2.9e-30 | 95.3 | In-house | 1-140 (141) | Show / Hide |
Range on Protein: 18-155 Range on HMM: 1-140/141 Sequence Identity: 34% (48 aa) PLVRVAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPGPRAPG-VA-ELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCT |.... | |.||. . | .. | | |.. .|| . | . |.|| | . ..| ..| . . .| | . |.. ||.|. |||||.| | passilpflllGnekdaadkdaldrlgikyvlnvttsvPnffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvvi AYLMRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEE |.|.| .||| .|...||..||. || .| || ..|. ayvmkhlslslseaykfvkekrPiisPnlnfmGqllefek |
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| Phosphatase | DUSP28.AA | Subfamily.DSP8.PD | 20-157 | 36 | 3e-30 | 95.4 | In-house | 3-142 (143) | Show / Hide |
Range on Protein: 20-157 Range on HMM: 3-142/143 Sequence Identity: 36% (51 aa) VRVAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPG--PRAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAY |. | |.||| . . || | . |.. .|.|...| . . ||.|| |. |.|| ... .. .. |..| | .||.| |.||||.| ||. trilpnlylGsqkdsldeellkklgisyvlnisescpkdvellkesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaiay LMRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEAL |.. .|| .|.. ||. || .|| | || .||. | imktlemsldeayrfvkekrptispnlnflgqLleyekel |
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| Phosphatase | DUSP28.AA | Subfamily.Slingshot.PD | 22-154 | 36 | 3.3e-29 | 91.8 | In-house | 5-137 (139) | Show / Hide |
Range on Protein: 22-154 Range on HMM: 5-137/139 Sequence Identity: 36% (49 aa) VAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPGPRAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLMRH . |.||| | |.| . ||. .||... . .. |.. |.|....|||.| . | .|.| ..| .||.|| | ||||.. || |.. ifdhlylGsewnasnleelkengveyilnvtkeidnffpekfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviayamke RGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYE .||| .|.. ||. | ...|| ||..||..|| yelsleealeyvkerrsiikpnkgflkqlkvye |
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| Phosphatase | DUSP28.AA | Subfamily.DSP15.PD | 21-155 | 33 | 1.6e-27 | 86.4 | In-house | 4-137 (138) | Show / Hide |
Range on Protein: 21-155 Range on HMM: 4-137/138 Sequence Identity: 33% (45 aa) RVAPSLFLGSARAAGAEEQLARAGVTLCVNVSrQQPGPRAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLMR .| | |..|. | | .||| . .| . . ... | ... |.... | | || ... . . .. ||..||.| | |||....||.| kvlpGlyvGnfrdakdkeqleenkithilsih-dsakplledikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayimt HRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEE || .|...||.||.||.|| || .|||..|. vtelswedalkavkaarsvanPnvGfrrqlqefek |
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| Phosphatase | DUSP28.AA | Subfamily.DSP6.PD | 20-155 | 29 | 6.5e-26 | 81.0 | In-house | 3-140 (141) | Show / Hide |
Range on Protein: 20-155 Range on HMM: 3-140/141 Sequence Identity: 29% (41 aa) VRVAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPGP--RAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAY |.. | |.||||..| | |.. .. .||. . | ... . ...|. | ..| ... . . .. | .. ..||.| | ||| .|. || veilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtlay LMRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEE ||... ||| .|...||. .. || | || ..|. lmkklalslndaydlvkkkksnisPnfnfmgqlldfer |
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| Phosphatase | DUSP28.AA | Subfamily.DSP3.PD | 22-155 | 30 | 3.2e-23 | 72.6 | In-house | 5-147 (148) | Show / Hide |
Range on Protein: 22-155 Range on HMM: 5-147/148 Sequence Identity: 30% (44 aa) VAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQP------GPR---APGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRA-GGACLVYCKNGRSRSA | | ...| . .| .|.|.. |.| .| .... .. .. | |.| | |. || .. | .. |.. .| || |..| |||| vypkvyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisRsa AVCTAYLMRHRGLSLAKAFQMVKSARPVAePNPGFWSQLQKYEE .. |||| .| |.| .| ..|.. | . || || .|| ...| tlvlayLmirrkltlkeaiktvrkkreil-PneGflkqLlelde |
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| Phosphatase | DUSP28.AA | Subfamily.LRR-DSP.PD | 22-155 | 30 | 3.4e-21 | 65.8 | In-house | 5-136 (137) | Show / Hide |
Range on Protein: 22-155 Range on HMM: 5-136/137 Sequence Identity: 30% (41 aa) VAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPgpRAPGV-AELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGaCLVYCKNGRSRSAAVCTAYLMR . . |.||. .| . | .|| . |. .| | . | . . | . |. |.. . | .. . || |..|. | ||||.. ||||. iidklylgcresamnksilkdnnvthilavadfkp--lypdlfkyliidiedvdeadiyqhfkemnafidegrekgg-vlihcragvsrsatlviaylmk HRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEE .. | . .|...|.. || ||.|| ||.|.|. knslkfkealdlvikkrpriypnrgfldqlkkfek |
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| Phosphatase | DUSP28.AA | Subfamily.STYXL1.PD | 26-155 | 31 | 2.3e-20 | 63.6 | In-house | 10-142 (143) | Show / Hide |
Range on Protein: 26-155 Range on HMM: 10-142/143 Sequence Identity: 31% (42 aa) LFLGSARAAGAEEQLARAGVTLCVNVSRQQpGPRAPG----VAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLMRH |.|| . | .. | |||| . .. | . .|...| |.. ||| .|. . .| .. | . ||. ..| |||||| |||| . lylGnykqaqnpaikkdlkvkahvnvssda-ekliagladvakllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaaviiaylmys RGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEE . ..| ||.. .| .. .|| .| .||...|. kkitlkkaykylkkckenvkPnrafveqlseWek |
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| Phosphatase | DUSP28.AA | Subfamily.STYX.PD | 22-154 | 35 | 6.9e-18 | 55.2 | In-house | 5-144 (146) | Show / Hide |
Range on Protein: 22-154 Range on HMM: 5-144/146 Sequence Identity: 35% (49 aa) VAPSLFLGSARAAG--AEEQLARAGVTLCVNVsRQQP-----GPRAPG-VAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAV . | |||| || |.| . |.| | . ||.. | | | . | |.. |... .| . . .. ... || ||. .| |||||. ilpglflgpysaamksklevlkehgithivci-rqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaal CTAYLMRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYE ||.| || .||..|. | . .|| || |||..|| viayimetyglkyreafayvqerrfcinpnegfvsqlkeye |
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| Phosphatase | DUSP28.AA | Subfamily.PTPMT1.PD | 60-155 | 31 | 1.6e-16 | 50.7 | In-house | 50-145 (146) | Show / Hide |
Range on Protein: 60-155 Range on HMM: 50-145/146 Sequence Identity: 31% (30 aa) APGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLMRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEE . || |.... | |..|| . .| | . |.|| ||.|||.. ..|||... || .| ...|. || . |.||...| klGveqlqlatvDfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlkskqwralqefke |
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| Phosphatase | DUSP28.AA | Subfamily.DSP23.PD | 43-138 | 22 | 1.1e-08 | 25.6 | In-house | 12-108 (128) | Show / Hide |
Range on Protein: 43-138 Range on HMM: 12-108/128 Sequence Identity: 22% (22 aa) AGVTLCVNVSRQQP----GPRAPGVAELRVPVFDDPAEDLLAHLeptCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLMRHRGLSLAKAFQMVKSARP |. |... . . . .. ...| | || . .|.| .| | . ..| |.| |. |. .. . ||....||. ..||. |. qGirvlvslttegapyseaapsltlrridipdfcPPaleqvarl---vriveeaekkeeavgvhcalGlGrtGtllacylvkeeglaaddaiaevrkrrk |
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| Phosphatase | DUSP28.AA | Subfamily.Laforin.PD | 61-140 | 29 | 8.8e-08 | 22.3 | In-house | 69-148 (165) | Show / Hide |
Range on Protein: 61-140 Range on HMM: 69-148/165 Sequence Identity: 29% (23 aa) PGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLMRHRGLSLAKAFQMVKSARPVA |.| . .|. | .| . | . . | . | |.|. | ||.|. .|. | |||| .. . |||. eglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv |
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| Phosphatase | DUSP28.AA | Subfamily.CDC14.PD | 91-138 | 31 | 1.6e-07 | 21.5 | In-house | 193-240 (258) | Show / Hide |
Range on Protein: 91-138 Range on HMM: 193-240/258 Sequence Identity: 31% (15 aa) AAVRAGGACLVYCKNGRSRSAAVCTAYLMRHRGLSLAKAFQMVKSARP .. .| || |.|| | | ... ..||..| ... | . .. ||| itekaeGaiavhCkaGLGrtgtligcylikhyrftaaetiawlriarP |
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| Phosphatase | DUSP28.AA | Subfamily.PTPDC1.PD | 89-139 | 28 | 6.6e-07 | 19.3 | In-house | 160-209 (229) | Show / Hide |
Range on Protein: 89-139 Range on HMM: 160-209/229 Sequence Identity: 28% (14 aa) MEAAVrAGGACLVYCKNGRSRSAAVCTAYLMRHRGLSLAKAFQMVKSARPV .. |. |. |.| |. | . ..||. .. |. ..| ..|.| || vdfal-eegkiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrpk |
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