Gene DUSP15
DUSP15
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of DUSP15.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | DUSP15.AA | Family.DSP.PD | 3-158 | 34 | 1e-36 | 117.8 | In-house | 105-263 (387) | Show / Hide |
Range on Protein: 3-158 Range on HMM: 105-263/387 Sequence Identity: 34% (54 aa) NGMTKVLPGLYLGNFIDAKDLDQLGRNKITHIISIH-ESPQPLL-QDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVT ......||.||||.. .||.|..| ....|.|... ..|| ..|.|||||. |... |. ..| ..|.||. .. ..|. |||| ||..||.|.. gkpseilphlylgsllaaknlewlkelgvtkivnltddkpqftkelgikylripidDhnapplenlfekaidfieegndskgvVlVHCkaGkgRsgtlii AYVMTVTGLGWRDVLEAIKATRP-IANPNPGFRQQLEEFGWASSQKLRRQLEERFGESP || | || . |. .. || ...|| || .||... .. ....| || .| aYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekeklkvssevmelrfviss |
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| Phosphatase | DUSP15.AA | Subfamily.DSP15.PD | 4-140 | 65 | 8.5e-74 | 236.8 | In-house | 1-137 (138) | Show / Hide |
Range on Protein: 4-140 Range on HMM: 1-137/138 Sequence Identity: 65% (90 aa) GMTKVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYV ||.|||||||.|||.|||| .||..||||||.|||.|..|||.||.||.|..||.|.....|.|||.|.|||.|||.|||.||||.||||||.|.|.||. gmnkvlpGlyvGnfrdakdkeqleenkithilsihdsakplledikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayi MTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFGW |||| |.|.|.|.|.||.|..|||| |||.||.|| . mtvtelswedalkavkaarsvanPnvGfrrqlqefek |
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| Phosphatase | DUSP15.AA | DSPc | 4-141 | 29 | 4.5e-45 | 156.99 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 4-141 Range on HMM: 1-172/172 Sequence Identity: 29% (50 aa) GMTKVLPGLYLGNFIDAK--DLDQLGRNKITHIISIHESPQ------------------PLLQDITYLRIP-VAD-------TPEVPIKKHFKECINFIH |.....|.||||. .. ....| ..|||.|. .. . ....|..|| . | .....| ..| |...||| GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH CCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAI-----KATR-PIANPNPGFRQQLEEFGWA || .||..||||.|||||| |.. || | .. ..| .... | | || .|| .| .|| |. DCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
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| Phosphatase | DUSP15.AA | Subfamily.DSP19.PD | 6-138 | 39 | 2.8e-38 | 121.7 | In-house | 3-136 (139) | Show / Hide |
Range on Protein: 6-138 Range on HMM: 3-136/139 Sequence Identity: 39% (53 aa) TKVLPGLYLGNFIDAKDLDQLGRNKITHIISIH-ESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVM ..| | |||| |.|...| ..|||||... . |. .|.||. |.. |.||. . ...||...||. | ..| |||| ||.|||...| ||.| aevkprlylgsqdvaadkeilkklkitHilnvavgvpnvfpkdftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylm TVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF . . | .. || ....|| ..|| || .||.|. kdeelslekalekvrearpcikPneGFikqLkey |
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| Phosphatase | DUSP15.AA | DSPc | 12-141 | 31 | 5.9e-38 | 133.89 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 12-141 Range on HMM: 1-151/151 Sequence Identity: 31% (47 aa) LYLGNFIDAK-DLDQLGRNKITHIISIH-ESPQPLL---QDITYLRIP-VAD---------TPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRST ||||.. ... |...| ..|||.|. | | . . ...|..|| | | .... | ..| ....||..|| .||..|||| |||||| LYLGSYPHHMADPAFLQKHGITHVINCTMECPNNWFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRSA TIVTAYVMTVTGLGWRDVLEAI-----KATR-PIANPNPGFRQQLEEFGWA ... || | .. .. .. . | | |. .||..| || |.. CLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
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| Phosphatase | DUSP15.AA | Subfamily.DSP12.PD | 5-138 | 36 | 6.4e-37 | 117.6 | In-house | 2-138 (143) | Show / Hide |
Range on Protein: 5-138 Range on HMM: 2-138/143 Sequence Identity: 36% (50 aa) MTKVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQD---ITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTA ....|||||||. .... ..| ||||..|. . ..| ||. ... |...|.|| .. .|..|...||. .. ..|. |||| ||.||| |||.| vseilpglylggleavqerellkelkithvlsvikeelpelqkekgvkskliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiviA YVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF |.| ..| .. |...|. .. ..|| || .|| | YlmkkeklslekAlklvkekkkeiepNegFleQLklf |
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| Phosphatase | DUSP15.AA | Subfamily.DSP1.PD | 6-138 | 39 | 3.7e-36 | 115.0 | In-house | 3-136 (139) | Show / Hide |
Range on Protein: 6-138 Range on HMM: 3-136/139 Sequence Identity: 39% (53 aa) TKVLPGLYLGNFIDAKDLDQLGRNKITHIISIHE-SPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVM ...|. |||| ..| .|..| . |||... . . |. . .| .||| |.... |...|.| |.||.... .|| |||| ||||||.||| ||.| veildfLyLGsaehasnlqlLkelkitallnvsaelpnvfeelfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayLm TVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF . . . .. | .| | | .|| || .|| || kekkvrleeafefvkqrrsiisPnfgfvgqLlef |
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| Phosphatase | DUSP15.AA | Subfamily.DSP14.PD | 5-138 | 36 | 3.7e-35 | 111.7 | In-house | 2-135 (138) | Show / Hide |
Range on Protein: 5-138 Range on HMM: 2-135/138 Sequence Identity: 36% (49 aa) MTKVLPGLYLGnFIDAKDLDQLGRNKITHIISI-HESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYV .... . |||. |.. ..| ..|||.|. . | |.. |.|. ...|.|.|.|| ...||.| . |. . .||..|||| ||.||| ..|.||. lseitesLyls-gaaalkkeklkkkkitlivnvttelpetkledvktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlayl MTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF | | |. ...|..||| .||.|| .|| .. mkyeklsLreayklvksaRpiirPnvGFwkqlidy |
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| Phosphatase | DUSP15.AA | Subfamily.DSP10.PD | 5-138 | 40 | 1.5e-34 | 109.6 | In-house | 2-138 (141) | Show / Hide |
Range on Protein: 5-138 Range on HMM: 2-138/141 Sequence Identity: 40% (55 aa) MTKVLPGLYLGNFIDAKDLDQLGRNKITHIISIHE-SPQPL--LQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTA ....|| |.||| ||.| | | | |.... . .|. ....| |||| |... .|..|.| ..||. | .|.. |||| ||||||.|.| | assilpflllGnekdaadkdaldrlgikyvlnvttsvPnffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvvia YVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF ||| ..| .. . .| ||| || .| || || yvmkhlslslseaykfvkekrPiisPnlnfmGqllef |
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| Phosphatase | DUSP15.AA | Subfamily.DSP6.PD | 7-138 | 34 | 2.4e-31 | 99.0 | In-house | 4-138 (141) | Show / Hide |
Range on Protein: 7-138 Range on HMM: 4-138/141 Sequence Identity: 34% (46 aa) KVLPGLYLGNFIDAKDLDQLGRNKITHIISIHES-PQPL--LQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYV ..|| ||||. ||..|. | . || ... . . |. ....|..||. |. . . |.| | |.|| .| . ..||||.||.||||.. ||.| eilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtlayl MTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF . | | . .|. .. || | .|| .| mkklalslndaydlvkkkksnisPnfnfmgqlldf |
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| Phosphatase | DUSP15.AA | Subfamily.LRR-DSP.PD | 7-138 | 39 | 5.9e-29 | 91.4 | In-house | 4-134 (137) | Show / Hide |
Range on Protein: 7-138 Range on HMM: 4-134/137 Sequence Identity: 39% (52 aa) KVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESpQPLLQDI-TYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGnCLVHCFAGISRSTTIVTAYVMT .....|||| |.. | |..|||... . .|| |. || | . |..|. | .|||| ||. | .|| |.|| ||.|||.|.| ||.| liidklylgcresamnksilkdnnvthilavadf-kplypdlfkyliidiedvdeadiyqhfkemnafidegrekgg-vlihcragvsrsatlviaylmk VTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF | ... |. .. || .||.|| .|| | knslkfkealdlvikkrpriypnrgfldqlkkf |
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| Phosphatase | DUSP15.AA | Subfamily.DSP8.PD | 4-138 | 37 | 3e-28 | 89.3 | In-house | 1-138 (143) | Show / Hide |
Range on Protein: 4-138 Range on HMM: 1-138/143 Sequence Identity: 37% (52 aa) GMTKVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQ---PLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVT |.|..|| |||| .|. | . | .. |.... | || . ||.. .||||| |. | . .|.....|| .| . |..||||.||||||.|.. gptrilpnlylGsqkdsldeellkklgisyvlnisescpkdvellkesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvai AYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF ||.| .. . . .| || .|| | .|| |. ayimktlemsldeayrfvkekrptispnlnflgqLley |
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| Phosphatase | DUSP15.AA | Subfamily.Slingshot.PD | 6-138 | 35 | 3.2e-28 | 89.0 | In-house | 3-136 (139) | Show / Hide |
Range on Protein: 6-138 Range on HMM: 3-136/139 Sequence Identity: 35% (47 aa) TKVLPGLYLGNFIDAKDLDQLGRNKITHIISIH-ESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVM .|. |||| .| .|..| .|....|. . | . ....||.| | |..| . ||..| .||. .. .| ..|||| |.|||...| || | skifdhlylGsewnasnleelkengveyilnvtkeidnffpekfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviayam TVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF .| . || .| | |..|| || .||... keyelsleealeyvkerrsiikpnkgflkqlkvy |
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| Phosphatase | DUSP15.AA | Subfamily.DSP3.PD | 7-137 | 35 | 4.7e-27 | 85.4 | In-house | 4-144 (148) | Show / Hide |
Range on Protein: 7-137 Range on HMM: 4-144/148 Sequence Identity: 35% (50 aa) KVLPGLYLGNFIDAKDLDQLGRNKITHIISIHES--------PQPLLQD--ITYLRIPVADTPEVPIKKHFKECINFIHCC-RLNGGNCLVHCFAGISRS | |..|.|. ||| ..| . |||.. |. . .| |.|| ..| |.||. ..|.|.| .||. . ..| |||| .|||||. evypkvyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisRs TTIVTAYVMTVTGLGWRDVLEAIKATRPIAnPNPGFRQQLEE |.| ||.| | .. ..... | | || || .|| | atlvlayLmirrkltlkeaiktvrkkreil-PneGflkqLle |
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| Phosphatase | DUSP15.AA | Subfamily.STYX.PD | 5-138 | 36 | 7.7e-27 | 84.7 | In-house | 2-143 (146) | Show / Hide |
Range on Protein: 5-138 Range on HMM: 2-143/146 Sequence Identity: 36% (51 aa) MTKVLPGLYLGNFIDAK--DLDQLGRNKITHIISIHESPQ-----P-LLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRST | ..||||.|| . |. |..| .. ||||. | .... | . ... || . |||.. | ... . .|| . .||. |||||||||... mqeilpglflgpysaamksklevlkehgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsa TIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF | ||.| || .|. .. | ||| || .||.|. alviayimetyglkyreafayvqerrfcinpnegfvsqlkey |
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| Phosphatase | DUSP15.AA | Subfamily.STYXL1.PD | 8-138 | 28 | 9e-17 | 52.4 | In-house | 5-140 (143) | Show / Hide |
Range on Protein: 8-138 Range on HMM: 5-140/143 Sequence Identity: 28% (39 aa) VLPG-LYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQDIT----YLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAY |||| |||||. .|.. |. . . ..|.. .. |.|.| |..| . ...|| ..||. . .| || |||||.... || vlPgklylGnykqaqnpaikkdlkvkahvnvssdaekliagladvakllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaaviiay VMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF .| . .. .. .| .. .|| .| .||.|. lmyskkitlkkaykylkkckenvkPnrafveqlseW |
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| Phosphatase | DUSP15.AA | Subfamily.PTPMT1.PD | 48-138 | 28 | 2.3e-16 | 50.7 | In-house | 53-143 (146) | Show / Hide |
Range on Protein: 48-138 Range on HMM: 53-143/146 Sequence Identity: 28% (26 aa) ITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEF ...|.... | |.| ... .| ..||. . .| . ||| || .||.|.|..|.|. . | . ...|. ||. . .. |.|| veqlqlatvDfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlkskqwralqef |
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| Phosphatase | DUSP15.AA | Subfamily.Laforin.PD | 47-125 | 26 | 3.2e-10 | 30.6 | In-house | 70-148 (165) | Show / Hide |
Range on Protein: 47-125 Range on HMM: 70-148/165 Sequence Identity: 26% (21 aa) DITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIA ..|. .|. | . . ... ..|. .| ||| ||. |||.|| ... | | . | . | ||.. glayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv |
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| Phosphatase | DUSP15.AA | Subfamily.R_Nematode_3.PD | 64-123 | 22 | 3.6e-08 | 23.8 | In-house | 181-246 (267) | Show / Hide |
Range on Protein: 64-123 Range on HMM: 181-246/267 Sequence Identity: 22% (15 aa) KKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVT---AYVMTVT---GLGWRDVLEAIKATRP ... || .. |. .. . . .|||..||||| |.. .| . .. | ......... |. peepkealelikfveksktpvvVHCsdGisRsatlaaielgyqliikskgkldllslikelrkqRa |
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| Phosphatase | DUSP15.AA | Subfamily.CDC14.PD | 72-123 | 23 | 6.1e-08 | 23.3 | In-house | 189-240 (258) | Show / Hide |
Range on Protein: 72-123 Range on HMM: 189-240/258 Sequence Identity: 23% (12 aa) NFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRP .|.. . |. ||| ||. | .|....|.. .. ... .. .|| kfleitekaeGaiavhCkaGLGrtgtligcylikhyrftaaetiawlriarP |
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| Phosphatase | DUSP15.AA | Subfamily.DSP23.PD | 28-123 | 19 | 4.1e-07 | 20.9 | In-house | 11-108 (128) | Show / Hide |
Range on Protein: 28-123 Range on HMM: 11-108/128 Sequence Identity: 19% (19 aa) RNKITHIISIHESPQPLL---QDITYLRIPVADTpEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRP . | ...|. . ..| ...|. || . | | . .. .. .. ... ||| |. |. |... |.. || | ... |. dqGirvlvslttegapyseaapsltlrridipdf-cPPaleqvarlvriveeaekkeeavgvhcalGlGrtGtllacylvkeeglaaddaiaevrkrrk |
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| Phosphatase | DUSP15.AA | Subfamily.PTPDC1.PD | 46-124 | 19 | 1.2e-06 | 18.9 | In-house | 133-209 (229) | Show / Hide |
Range on Protein: 46-124 Range on HMM: 133-209/229 Sequence Identity: 19% (15 aa) QDITYLRIPVADTPEVPIKKHFkECINFIHCCrLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPI |.|.. .. .| ..... . . . |. |. ||| || | ....|.. .. |. . .. ... || qgiyfynfglkDygvasleriL-divkvvdfa-leegkiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrpk |
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| Phosphatase | DUSP15.AA | Subfamily.N_Nematode_1.PD | 69-104 | 37 | 4.3e-06 | 16.9 | In-house | 184-220 (265) | Show / Hide |
Range on Protein: 69-104 Range on HMM: 184-220/265 Sequence Identity: 37% (13 aa) ECINFIHCCRLNGGNCLVHCFAGISRSTTIVT-AYVM ..... | . | .||| ||| |. |||. .|.. aalelleavrgskgPivvhCsaGiGrtGtivaieyil |
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| Phosphatase | DUSP15.AA | Subfamily.DSP11.PD | 52-122 | 29 | 6e-06 | 16.8 | In-house | 51-122 (141) | Show / Hide |
Range on Protein: 52-122 Range on HMM: 51-122/141 Sequence Identity: 29% (21 aa) RIPVADTPEVPIKKHFKECI-NFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATR ..| ..|| . |.||| . .|.. . |. ||| |. |. .. |.. |.|. | .|| . .| ncpGhevpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyspedaieafeear |
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| Phosphatase | DUSP15.AA | Subfamily.R_Nematode_2.PD | 62-102 | 24 | 8e-06 | 16.0 | In-house | 174-215 (261) | Show / Hide |
Range on Protein: 62-102 Range on HMM: 174-215/261 Sequence Identity: 24% (10 aa) PIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTA-Y . | .|. . .. . . .||| ||| |....... | gvPkshaelfeLlelvkksekPivvhCsaGiGRtmafigtey |
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