• Phosphatome.Net

Gene DUSP22

DUSP22
Species: Human
Alias: MKPX, VHX, FLJ35864, LMWDSP2, JSP1, JKAP, DUSP22
External Links: COSMIC , Entrez Gene
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: DSP
Subfamily: DSP15
Protein domain

Protein domains of DUSP22.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase DUSP22.AA Family.DSP.PD 3-148 36 1.5e-39 127.5 In-house 105-253 (387) Show / Hide 
Range on Protein: 3-148
Range on HMM: 105-253/387
Sequence Identity: 36% (54 aa)

NGMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVH-DSARPML-EGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVI
.....|||.||.|....| . |.|....||.|...  |. . .  .|.|||.||  |.....| ..| ..|.||.|..  ..  |||| ||..||||.||
gkpseilphlylgsllaaknlewlkelgvtkivnltddkpqftkelgikylripidDhnapplenlfekaidfieegndskgvVlVHCkaGkgRsgtlii

AYIMTVTDFGWEDALHTVRAGRS-CANPNVGFQRQLQEFEKHEVHQYRQ
|.|   ..  |.||. ||  |. ...|| || .||...||  ... .. 
aYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekeklkvsse
Phosphatase DUSP22.AA Subfamily.DSP15.PD 4-141 73 2.1e-78 252.0 In-house 1-138 (138) Show / Hide 
Range on Protein: 4-141
Range on HMM: 1-138/138
Sequence Identity: 73% (101 aa)

GMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYI
||||.|||||.|||.||.|.|||..||.|||||.||||.|.||..|||||.|||||.|.|...|||||.|||.|||.|...|||||||.|||||||.|||
gmnkvlpGlyvGnfrdakdkeqleenkithilsihdsakplledikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayi

MTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKH
||||...|||||..|.|.||.|||||||.||||||||.
mtvtelswedalkavkaarsvanPnvGfrrqlqefekk
Phosphatase DUSP22.AA DSPc 4-141 29 9.6e-51 175.82 SMART 1-172 (172) Show / Hide 
Range on Protein: 4-141
Range on HMM: 1-172/172
Sequence Identity: 29% (51 aa)

GMNKILPGLYIGNFKDAR--DAEQLSKNKVTHILSVHDSARPMLE------------------GVKYLCIP-AAD-------SPSQNLTRHFKESIKFIH
|. .|.|.||.|. ...   ....|.|...||...| .. .. ..                  .  |..||   |       ....|.. .| |...|||
GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH

ECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTV-----RAGR-SCANPNVGFQRQLQEFEKH
.|| .|  .||||.||.|||.||.|||.|    . ..||.| |     .  | .. .||..|..||.|.|. 
DCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK
Phosphatase DUSP22.AA DSPc 12-141 29 1.4e-44 156.94 Pfam 1-151 (151) Show / Hide 
Range on Protein: 12-141
Range on HMM: 1-151/151
Sequence Identity: 29% (44 aa)

LYIGNFKDAR-DAEQLSKNKVTHILSVHDSAR-PML---EGVKYLCIP-AAD---------SPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSV
||.|.....  | ..|.|...||.... .. . . .   ..  |..||   |         ....|.. .| ....||. || .|. .||||.||.|||.
LYLGSYPHHMADPAFLQKHGITHVINCTMECPNNWFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRSA

TLVIAYIMTVTDFGWEDALHTV-----RAGR-SCANPNVGFQRQLQEFEKH
.|.|||.|    .  ..|.. |     .  | .. .||..|.|||.|.|. 
CLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ
Phosphatase DUSP22.AA Subfamily.DSP12.PD 5-141 42 4.4e-40 128.2 In-house 2-141 (143) Show / Hide 
Range on Protein: 5-141
Range on HMM: 2-141/143
Sequence Identity: 42% (59 aa)

MNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARP---MLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIA
...||||||.|. ... . |.|.. |.||.|||   . |     .|||.. |...|.|...| .|..| ..||.|.. .... |||||||||||||.|||
vseilpglylggleavqerellkelkithvlsvikeelpelqkekgvkskliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiviA

YIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKH
|.|  ...  |.||..|.. .. ..|| ||..||. ||| 
YlmkkeklslekAlklvkekkkeiepNegFleQLklfekm
Phosphatase DUSP22.AA Subfamily.DSP19.PD 6-140 41 9.2e-40 126.8 In-house 3-138 (139) Show / Hide 
Range on Protein: 6-140
Range on HMM: 3-138/139
Sequence Identity: 41% (56 aa)

NKILPGLYIGNFKDARDAEQLSKNKVTHILSVH-DSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIM
.. | ||.|    | | |.|.|.|.||||.|  .  .   . ..|..|.  | | ..|....||...||.| | ..   |||| ||||||...||||.|.
aevkprlylgsqdvaadkeilkklkitHilnvavgvpnvfpkdftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylm

TVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEK
 ..   |.||..||. | |..|| ||..||.|.|. 
kdeelslekalekvrearpcikPneGFikqLkeyea
Phosphatase DUSP22.AA Subfamily.DSP6.PD 7-140 42 3e-39 125.0 In-house 4-140 (141) Show / Hide 
Range on Protein: 7-140
Range on HMM: 4-140/141
Sequence Identity: 42% (58 aa)

KILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARP---MLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYI
.||| ||.|. ||| . | |.| |. ..| | .         . .||. ||. |  ||||...| |.|.|| |.| . ...|||||||||||||...||.
eilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtlayl

MTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEK
|  . .  .|| . |.. .|   ||  |  || .||.
mkklalslndaydlvkkkksnisPnfnfmgqlldfer
Phosphatase DUSP22.AA Subfamily.DSP10.PD 5-140 41 5.1e-37 118.0 In-house 2-140 (141) Show / Hide 
Range on Protein: 5-140
Range on HMM: 2-140/141
Sequence Identity: 41% (58 aa)

MNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPML--EGV-KYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIA
. .||| |..|| |||.| . |..  ....| |  |.  .   .|. .|  ||. ||. ||| ..|.|...||.| | ||.. |||| ||.|||.|.|||
assilpflllGnekdaadkdaldrlgikyvlnvttsvPnffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvvia

YIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEK
|.|  ..   ..| . |.  |    ||..|  || ||||
yvmkhlslslseaykfvkekrPiisPnlnfmGqllefek
Phosphatase DUSP22.AA Subfamily.DSP1.PD 6-140 38 2e-35 113.0 In-house 3-138 (139) Show / Hide 
Range on Protein: 6-140
Range on HMM: 3-138/139
Sequence Identity: 38% (52 aa)

NKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEG-VKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIM
..||. ||.|  ..| . ..|.. |.|..| |  .   . |   || .||  |....... .|.| |.||.... .|   |||| ||.||||.|.||.|.
veildfLyLGsaehasnlqlLkelkitallnvsaelpnvfeelfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayLm

TVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEK
 . .  |.| . |.  ||. .||.|| .|| |||| 
kekkvrleeafefvkqrrsiisPnfgfvgqLlefek
Phosphatase DUSP22.AA Subfamily.LRR-DSP.PD 7-140 42 3.5e-34 108.7 In-house 4-136 (137) Show / Hide 
Range on Protein: 7-140
Range on HMM: 4-136/137
Sequence Identity: 42% (57 aa)

KILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGeSCLVHCLAGVSRSVTLVIAYIMTV
.|...||.|  . | ..  | .|.|||||.| |      .  ||| | . | .  .. .||||   ||.| | .|   |.|| ||||||||||||.|   
liidklylgcresamnksilkdnnvthilavadfkplypdlfkyliidiedvdeadiyqhfkemnafidegrekg-gvlihcragvsrsatlviaylmkk

TDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEK
 . ...||  |  .|.  .|| ||. ||. ||| 
nslkfkealdlvikkrpriypnrgfldqlkkfek
Phosphatase DUSP22.AA Subfamily.DSP14.PD 5-140 37 4.2e-34 108.6 In-house 2-137 (138) Show / Hide 
Range on Protein: 5-140
Range on HMM: 2-137/138
Sequence Identity: 37% (52 aa)

MNKILPGLYIGnFKDARDAEQLSKNKVTHILSVH-DSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYI
...| . ||..  . |.. |.|.|.|.|.|. |  . . . ||.||.. |. .|.|...|..||.|  . |.| . .|  .|||| |||||| .||.||.
lseitesLyls-gaaalkkeklkkkkitlivnvttelpetkledvktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlayl

MTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEK
|       ..| ..|.. |.  .||||| .||...||
mkyeklsLreayklvksaRpiirPnvGFwkqlidyEk
Phosphatase DUSP22.AA Subfamily.DSP8.PD 5-141 36 1.3e-31 100.7 In-house 2-141 (143) Show / Hide 
Range on Protein: 5-141
Range on HMM: 2-141/143
Sequence Identity: 36% (51 aa)

MNKILPGLYIGNFKDARDAEQLSKNKVTHIL--SVHDSA-RPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIA
...||| ||.|  ||. | | |.|. ....|  | .  .   .|. ...| ||  |. . .|  .|.....||  .|    ..||||||| ||| |..||
ptrilpnlylGsqkdsldeellkklgisyvlnisescpkdvellkesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaia

YIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKH
|||   ... ..| . |.  |.  .||. |  || |.||.
yimktlemsldeayrfvkekrptispnlnflgqLleyeke
Phosphatase DUSP22.AA Subfamily.DSP3.PD 5-140 33 5.5e-31 98.5 In-house 2-147 (148) Show / Hide 
Range on Protein: 5-140
Range on HMM: 2-147/148
Sequence Identity: 33% (49 aa)

MNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSAR--------PMLE--GVKYLCIPAADSPSQNLTRHFKESIKFIHECRLR-GESCLVHCLAGVS
.. . |..|.|. . |.| |.| |  .||.|   .. |         . .  ..||| ... |.|. .| ..|.|. .||.|   . .   |||| .|.|
vdevypkvyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGis

RSVTLVIAYIMTVTDFGWEDALHTVRAGRSCaNPNVGFQRQLQEFEK
|| |||.||.|   ..  ..|..|||  |.   || || .|| |...
RsatlvlayLmirrkltlkeaiktvrkkrei-lPneGflkqLlelde
Phosphatase DUSP22.AA Subfamily.Slingshot.PD 6-139 38 1e-30 97.5 In-house 3-137 (139) Show / Hide 
Range on Protein: 6-139
Range on HMM: 3-137/139
Sequence Identity: 38% (52 aa)

NKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLE-GVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIM
||   ||.|   .| . |.|..|.|..|| |      . .  .||| |   |.....| .|..|. |||.... .| ..||||  ||||| . |||| | 
skifdhlylGsewnasnleelkengveyilnvtkeidnffpekfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviayam

TVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFE
  ..  |.||. |.  ||...|| || .||...| 
keyelsleealeyvkerrsiikpnkgflkqlkvye
Phosphatase DUSP22.AA Subfamily.STYX.PD 5-139 36 4.8e-28 89.0 In-house 2-144 (146) Show / Hide 
Range on Protein: 5-139
Range on HMM: 2-144/146
Sequence Identity: 36% (51 aa)

MNKILPGLYIGNFKDARDA--EQLSKNKVTHILSVHDSA-----RPML-EGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSV
|..|||||..| .  |  .  |.| .. .|||. . ..      .| . .  .|| .  ||.. .|. |.. .  .|| ..  .|   |||||.||| .|
mqeilpglflgpysaamksklevlkehgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsa

TLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFE
||||||    . . .| . |.  | | ||| || .||.|.|  
alviayimetyglkyreafayvqerrfcinpnegfvsqlkeye
Phosphatase DUSP22.AA Subfamily.STYXL1.PD 8-140 31 4.7e-23 73.1 In-house 5-142 (143) Show / Hide 
Range on Protein: 8-140
Range on HMM: 5-142/143
Sequence Identity: 31% (43 aa)

ILPG-LYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEGVKY----LCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAY
.||| ||.||.|.| . .     ||   . |   | ....|..     | |.  |..  .|  ..|| ..||.. . .||  ||    |.|||....|||
vlPgklylGnykqaqnpaikkdlkvkahvnvssdaekliagladvakllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaaviiay

IMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEK
.|   ..  ..|.. ..  ..  .|| .|  ||.|.||
lmyskkitlkkaykylkkckenvkPnrafveqlseWek
Phosphatase DUSP22.AA Subfamily.PTPMT1.PD 46-140 30 3e-17 53.9 In-house 51-145 (146) Show / Hide 
Range on Protein: 46-140
Range on HMM: 51-145/146
Sequence Identity: 30% (29 aa)

EGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEK
.||..| ..  |      . . .|...||.. . .|.|  ||| || .|| |||..|.|. . .  |.| ..... |.    .    | ||||..
lGveqlqlatvDfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlkskqwralqefke
Phosphatase DUSP22.AA Subfamily.Laforin.PD 46-113 26 4.2e-09 27.4 In-house 69-136 (165) Show / Hide 
Range on Protein: 46-113
Range on HMM: 69-136/165
Sequence Identity: 26% (17 aa)

EGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWED
||. |. .|  |  ...  . . ... ..|    .|    ||| ||| || ..|  ... | ..    
eglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslak
Phosphatase DUSP22.AA Subfamily.DSP23.PD 31-135 20 8.7e-09 26.7 In-house 14-120 (128) Show / Hide 
Range on Protein: 31-135
Range on HMM: 14-120/128
Sequence Identity: 20% (22 aa)

VTHILSVHDSARPMLEGVK---Y--LCIPAADSPSQNltrHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCA
. ...|. . ..|  | ..   .  . ||    |. .     .. .. ..|   ..|.  |||. |. |. ||.  |..   ..  .||.||  |  .  
irvlvslttegapyseaapsltlrridipdfcPPale---qvarlvriveeaekkeeavgvhcalGlGrtGtllacylvkeeglaaddaiaevrkrrkGs

NPNVGFQRQL
 |  .. .  
ietveqekav
Phosphatase DUSP22.AA Subfamily.DSP11.PD 49-123 29 2.6e-08 24.9 In-house 46-123 (141) Show / Hide 
Range on Protein: 49-123
Range on HMM: 46-123/141
Sequence Identity: 29% (23 aa)

KY--LCIPAADSPSQNLTRHFKESIK-FIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRS
||  | .|  . |...  ..||| .| |....   ..   |||  || |.  |.  |.. |...  |||...    | 
kykklncpGhevpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyspedaieafeearG
Phosphatase DUSP22.AA Subfamily.PTPDC1.PD 46-125 22 6.9e-08 23.3 In-house 133-210 (229) Show / Hide 
Range on Protein: 46-125
Range on HMM: 133-210/229
Sequence Identity: 22% (18 aa)

EGVKYLCIPAADSPSQNLTRHFkESIKFIHECRlRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCA
.|. .  .. .|  .. |.|   . .| .     .     ||| ||  |   |. .|.. ..... |.|...||. |. .
qgiyfynfglkDygvasleriL-divkvvdfal-eegkiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrpks
Phosphatase DUSP22.AA Subfamily.RNGTT.PD 51-123 25 1.2e-07 22.7 In-house 50-121 (140) Show / Hide 
Range on Protein: 51-123
Range on HMM: 50-121/140
Sequence Identity: 25% (18 aa)

LCIPAADSPSQNLTRHFKESIKFIHEcRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRS
|    ..|... |..| . .|  .. .  .|   |||  |  |   |..||.. . |.. |.|...    |  
qcrGrGeaPtkeqtklfiklvkeflk-kkPdevigvhCthGfnrtGflivayLvekedwsveaavalfakarp
Phosphatase DUSP22.AA Subfamily.R_Nematode_3.PD 62-103 30 2.1e-07 21.6 In-house 179-220 (267) Show / Hide 
Range on Protein: 62-103
Range on HMM: 179-220/267
Sequence Identity: 30% (13 aa)

NLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYI
|   . || .. |. ..    . .||| .|.||| ||. . .
napeepkealelikfveksktpvvVHCsdGisRsatlaaiel
Phosphatase DUSP22.AA Subfamily.CDC14.PD 75-122 25 2e-06 18.7 In-house 195-239 (258) Show / Hide 
Range on Protein: 75-122
Range on HMM: 195-239/258
Sequence Identity: 25% (12 aa)

HECrlrGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGR
..     .  ||| ||. |  ||. .|..    |  ....  .|  | 
eka---eGaiavhCkaGLGrtgtligcylikhyrftaaetiawlriar
Phosphatase DUSP22.AA Subfamily.PRL.PD 46-126 24 4.1e-06 17.8 In-house 45-125 (140) Show / Hide 
Range on Protein: 46-126
Range on HMM: 45-125/140
Sequence Identity: 24% (20 aa)

EGVKYL--CIPAADSPSQNLTRHFKESIKFIHECRlRGESCLVHCLAGVSRSVTLVIAYIMtVTDFGWEDALHTVRAGRSCAN
||.. |  .     .|.... ... | .|  .. .  ...  |||.||. |.  ||   ..  . .  |||.. .|  |  | 
egievldlafddGavPpkevvdeWlellkekfkee-pkstvavhcvaGlGraPvlvalali-eaGmkyedavefirekrrgai
Sequence
Name Sequence Type Origin Length Description Download
DUSP22.AA Protein None 184 None Fasta, JSON
DUSP22.NA RNA None 552 None Fasta, JSON
DUSP22.AA.PD_4-146 Protein Phosphatase Domain None 143 None Fasta, JSON