Gene DUSP27
DUSP27
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of DUSP27.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | DUSP27.AA | Family.DSP.PD | 129-284 | 35 | 4.8e-30 | 95.3 | In-house | 102-253 (387) | Show / Hide |
Range on Protein: 129-284 Range on HMM: 102-253/387 Sequence Identity: 35% (54 aa) APWNEVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAhgtgvYTGPEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALlTYRGKVLVSSEMG ... |..|..... . | |. ||.||.|.|.|.. . |.|. |.|.|| . .||... .....| || .|..|. .|.|||.|..||.. vengkpseilphlylgsllaaknlewlkelgvtkivnlt-----ddkpqftkelgikylripidDhnapplenlfekaidfieegn-dskgvVlVHCkaG ISRSAVLVVAYLMIFHNMAILEALMTVRKKR--AIYPNEGFLKQLRELNEKLMEEREE |..|||| .... ||| ||.|| | ||.|||||| .| ........| kgRsgtliiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekeklkvsse |
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| Phosphatase | DUSP27.AA | Subfamily.DSP3.PD | 133-277 | 59 | 7e-66 | 210.8 | In-house | 1-148 (148) | Show / Hide |
Range on Protein: 133-277 Range on HMM: 1-148/148 Sequence Identity: 59% (88 aa) EVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHG---TGVYTGPEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTYRGKVLVSSEMGI |||||.|.|......|| .| .||.|||||.||||.| . | |..|||..|||.||||||.|.||.|.|..|..|..|.|||| . .|||||....|| evdevypkvyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGi SRSAVLVVAYLMIFHNMAILEALMTVRKKRAIYPNEGFLKQLRELNEK ||||.||.|||||...... ||..||||||.|.|||||||||.||.|| sRsatlvlayLmirrkltlkeaiktvrkkreilPneGflkqLleldek |
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| Phosphatase | DUSP27.AA | DSPc | 141-277 | 29 | 2.2e-34 | 121.49 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 141-277 Range on HMM: 1-151/151 Sequence Identity: 29% (47 aa) VFIAEKSVAV-NKGRLKRLGITHILNAA-----HGTGVYTGPEFYTGLEIQYLGVE-VDD---------FPEVDISQHFRKASEFLDEALLTYRGKVLVS .... .... .. |. .||||..|.. . ||.. ...|... |.| .....|||.|..|..|.| . .. ||||| LYLGSYPHHMADPAFLQKHGITHVINCTMECPNN--------WFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDC-RQKGGKVLVH SEMGISRSAVLVVAYLMIFHNMAILEALMTV-----RKKR-A-IYPNEGFLKQLRELNEK .|||||| |..|||| .|| ||. | ...| |.|| .|..||.|.. . CQAGISRSACLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
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| Phosphatase | DUSP27.AA | DSPc | 133-277 | 28 | 1.2e-32 | 115.66 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 133-277 Range on HMM: 1-172/172 Sequence Identity: 28% (50 aa) EVDEVWPNVFIAEKSVAV--NKGRLKRLGITHILNAAHGTGV-----------YTGPEFYTGLEIQYLGVE-VDD-------FPEVDISQHFRKASEFLD .. |. |..... ..... |. || ..|||..|.. . . || .| . ..||... .|| .....|||.| ....|.. GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH EALLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEALMTV-----RKKR-A-IYPNEGFLKQLRELNEK .. ...||||| .|||||| |..|||| .|| . .|. | ...| |.||..|..||.|.. | DC-RQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
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| Phosphatase | DUSP27.AA | Subfamily.DSP19.PD | 134-275 | 40 | 5.8e-32 | 100.6 | In-house | 2-137 (139) | Show / Hide |
Range on Protein: 134-275 Range on HMM: 2-137/139 Sequence Identity: 40% (57 aa) VDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTgvytgPEFYTgLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTYrGKVLVSSEMGISRSA | || |..... ..|| .| ||.|.|||||| | |. |.... ...|. .|. | ||... .....| .|..||. . | |||. |.|||| . vaevkprlylgsqdvaadkeilkklkitHilnvavgv-----pnvfp-kdftyksieilDlpetkllsylkealdFieearskd-grvlvHCnAGvSRsa VLVVAYLMIFHNMAILEALMTVRKKR-AIYPNEGFLKQLRELN |.|||| ... . .|| .||..| .| |||||.|||.|.. svviaylmkdeelslekalekvrearpcikPneGFikqLkeye |
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| Phosphatase | DUSP27.AA | Subfamily.DSP12.PD | 134-273 | 34 | 8.1e-28 | 87.5 | In-house | 2-137 (143) | Show / Hide |
Range on Protein: 134-273 Range on HMM: 2-137/143 Sequence Identity: 34% (48 aa) VDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGvytgPEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALlTYRGKVLVSSEMGISRSA |.|. |...... . .... .|| | |||.| .. . ||. . . ... ....| || |. .|. .| .|..|.| .|.|||..|.|||. . vseilpglylggleavqerellkelkithvlsvikeel----pelqkekgvkskliqilDepeedlLshldeavrFieegl-ekegavlvHClagvSRSv VLVVAYLMIFHNMAILEALMTVR-KKRAIYPNEGFLKQLRE |.|||| ... . .|| .|. ||. |.||||||.||. tiviAYlmkkeklslekAlklvkekkkeiepNegFleQLkl |
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| Phosphatase | DUSP27.AA | Subfamily.LRR-DSP.PD | 135-275 | 39 | 2e-27 | 85.9 | In-house | 3-135 (137) | Show / Hide |
Range on Protein: 135-275 Range on HMM: 3-135/137 Sequence Identity: 39% (55 aa) DEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVYtgPEFYtgleiQYLGVEVDDFPEVDISQHFRKASEFLDEAllTYRGKVLVSSEMGISRSAV |.. ..... . | || || ...|||| |. .| |. . .|| ....| .|.||.|||.. |.|| .| ||.|.|||| ||.| dliidklylgcresamnksilkdnnvthilavadfkply--pdlf-----kyliidiedvdeadiyqhfkemnafideg--rekggvlihcragvsrsat LVVAYLMIFHNMAILEALMTVRKKR-AIYPNEGFLKQLRELN ||| ... . ||| | ||| ||||.|||.||. . lviaylmkknslkfkealdlvikkrpriypnrgfldqlkkfe |
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| Phosphatase | DUSP27.AA | Subfamily.DSP1.PD | 136-275 | 34 | 4.6e-27 | 84.9 | In-house | 4-137 (139) | Show / Hide |
Range on Protein: 136-275 Range on HMM: 4-137/139 Sequence Identity: 34% (49 aa) EVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTgvytgPEFYTGLeIQYLGVEVDDFPEVDISQHFRKASEFLDEAlLTYRGKVLVSSEMGISRSAVL |. . ... .. | |. ||.|.||..|| . . |. . | .| ..|.| ...|||..|..| .|.|.. . .|.||| ..|||||| . eildfLyLGsaehasnlqlLkelkitallnvsael-----pnvfeel-fkyksipvednkkadisslfeeaidfidsv-kkkgGrvlvhCqaGisrsati VVAYLMIFHNMAILEALMTVRKKRAI-YPNEGFLKQLRELN |.|||| ... . || |...|.| || ||..|| | . vlayLmkekkvrleeafefvkqrrsiisPnfgfvgqLlefe |
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| Phosphatase | DUSP27.AA | Subfamily.DSP14.PD | 135-276 | 32 | 5.3e-26 | 81.5 | In-house | 3-137 (138) | Show / Hide |
Range on Protein: 135-276 Range on HMM: 3-137/138 Sequence Identity: 32% (45 aa) DEVWPNVFIAeKSVAVNKGRLKRLGITHILNAAHgtgvyTGPEFYtGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEAlLTYRGKVLVSSEMGISRSAV |. ...... ..|..| ||. .||.|.|.. || . ..... ..|.| || ....|| .... ..|. . ||.||.|.|||| ||.| seitesLyls-gaaalkkeklkkkkitlivnvtt-----elpetk-ledvktvkikveDkpeaklaehfdevadkieev-kkkgGktlvhCvaGvsRsAs LVVAYLMIFHNMAILEALMTVRKKRA-IYPNEGFLKQLRELNE ||| ...... || .|...|. | || || |||..... lvlaylmkyeklsLreayklvksaRpiirPnvGFwkqlidyEk |
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| Phosphatase | DUSP27.AA | Subfamily.DSP10.PD | 136-276 | 33 | 1.3e-24 | 76.9 | In-house | 4-140 (141) | Show / Hide |
Range on Protein: 136-276 Range on HMM: 4-140/141 Sequence Identity: 33% (47 aa) EVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHgtgvyTGPEFYTGLEI-QYLGVEVDDFPEVDISQHFRKASEFLDEALLTyRGKVLVSSEMGISRSAV .. | ... .. | .| |.||||...|| . . | |... .. .| ..| | .. ...|.| .| ||..|| . ..|||. |||||| .| silpflllGnekdaadkdaldrlgikyvlnvtt-----svPnffeekglvrykripvsdsgkqnlkqkfeealefieearkr-gsrvlvhchaGisrsat LVVAYLMIFHNMAILEALMTVRKKRA-IYPNEGFLKQLRELNE .||.| . .... || |..|| | || .|. || |... vviayvmkhlslslseaykfvkekrPiisPnlnfmGqllefek |
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| Phosphatase | DUSP27.AA | Subfamily.DSP15.PD | 134-275 | 33 | 1.3e-22 | 70.4 | In-house | 2-136 (138) | Show / Hide |
Range on Protein: 134-275 Range on HMM: 2-136/138 Sequence Identity: 33% (46 aa) VDEVWPNVFIAEKSVAVNKGRLKRLGITHILNaahgtgVYTGPEFYTgLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTyRGKVLVSSEMGISRSA ...| | ... . | .| .|.. ||||| .. .. .|.|| ....| |..|.|..|... .|. .. | |.|||||||| ||| mnkvlpGlyvGnfrdakdkeqleenkithils------ihdsakpll-edikylcikaadsPdqdlskffkesidfihkcrle-ggnvlvhclaGisrsv VLVVAYLMIFHNMAILEALMTVRKKRAI-YPNEGFLKQLRELN ||.| .. .|| .|. |.. || || .||.| . tlvvayimtvtelswedalkavkaarsvanPnvGfrrqlqefe |
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| Phosphatase | DUSP27.AA | Subfamily.Slingshot.PD | 137-273 | 34 | 5.1e-22 | 68.4 | In-house | 5-135 (139) | Show / Hide |
Range on Protein: 137-273 Range on HMM: 5-135/139 Sequence Identity: 34% (46 aa) VWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTgvytgPEFYTGlEIQYLGVEVDDFPEVDISQHFRKASEFLDEALlTYRGKVLVSSEMGISRSAVLV .. ... . | | ||. |...||| .. .|. . ...|| . | | .| |. .|. .. .|...| . ||||||.|||| |.|| ifdhlylGsewnasnleelkengveyilnvtkei-----dnffpe-kfkylnirvydeeetdllkhwnetykfiekak-ekgskvlvhckmGvsrsastv VAYLMIFHNMAILEALMTVRKKRAI-YPNEGFLKQLRE | ... . ||| |...| | ||.||||||.. iayamkeyelsleealeyvkerrsiikpnkgflkqlkv |
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| Phosphatase | DUSP27.AA | Subfamily.DSP6.PD | 137-275 | 30 | 9.6e-22 | 67.3 | In-house | 5-139 (141) | Show / Hide |
Range on Protein: 137-275 Range on HMM: 5-139/141 Sequence Identity: 30% (42 aa) VWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTgvytGPEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTyRGKVLVSSEMGISRSAVLV . |.... . | | ||.|.| ..|| .. | |..|. . ..| . .....| .| ||.||| . |||| |.||| .. ilpllylGsakdasnlevlkklkikyvlnvtsnl----pnkfeesgelkykqipiedhlsqnlakffPeaiefidearsk-kskvlvhclaGvsrsvtvt VAYLMIFHNMAILEALMTVRKKR-AIYPNEGFLKQLRELN .|||| ..... .| |.||. | || |..|| . . laylmkklalslndaydlvkkkksnisPnfnfmgqlldfe |
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| Phosphatase | DUSP27.AA | Subfamily.STYX.PD | 133-274 | 36 | 1.8e-21 | 66.7 | In-house | 1-143 (146) | Show / Hide |
Range on Protein: 133-274 Range on HMM: 1-143/146 Sequence Identity: 36% (53 aa) EVDEVWPNVFIAEKSVAVNK--GRLKRLGITHILNAAHGT-GVYTGPEFYTglEIQYLGVEVDDFPEVDISQHFRKASEFLDEALlTYRGKVLVSSEMGI |..|. | .|. | |.. ||. |||||. . |.| ...|| ..| | . .| ... .. ||.|..| . ||||| . || emqeilpglflgpysaamksklevlkehgithivcirqnieanlikpnfpd--rfrylvldvadntveniirylptvkefiddsl-qkggkvlvhgnagi SRSAVLVVAYLMIFHNMAILEALMTVRKKR-AIYPNEGFLKQLREL |||| ||.||.| . .. || . |...| | ||||| .||.| srsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkey |
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| Phosphatase | DUSP27.AA | Subfamily.STYXL1.PD | 139-276 | 26 | 9.6e-20 | 61.4 | In-house | 7-142 (143) | Show / Hide |
Range on Protein: 139-276 Range on HMM: 7-142/143 Sequence Identity: 26% (37 aa) P-NVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVytgpeFYTGLEI--QYLGVEVDDFPEVDISQHFRKASEFLDEALLtYRGKVLVSSEMGISRSAVL | .... . . |.|. | | . .| .. .. ...||. . | ..|.| .| |. ...... .|... |||.|. |||||| . PgklylGnykqaqnpaikkdlkvkahvnvssdaek-----liagladvakllhiavedeneadllerlkevvqfiekhkk-egevvlvfsnkGisrsaav VVAYLMIFHNMAILEALMTVRK-KRAIYPNEGFLKQLRELNE ..|||| .... .|. ..| | . || .|..||.| .. iiaylmyskkitlkkaykylkkckenvkPnrafveqlseWek |
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| Phosphatase | DUSP27.AA | Subfamily.DSP8.PD | 136-277 | 35 | 2.8e-19 | 59.7 | In-house | 4-141 (143) | Show / Hide |
Range on Protein: 136-277 Range on HMM: 4-141/143 Sequence Identity: 35% (50 aa) EVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVytGPEFYTglEIQYLGVEVDDFPEVDISQHFRKASEFLDEALlTYRGKVLVSSEMGISRSAVL .. ||... . ..... ||.|||...||... . .|. . | ..| . | | | .....| || ||.| | . ||||||||||| ...|| rilpnlylGsqkdsldeellkklgisyvlnisescpk--dvellk--esrflriPvkDkyeekllpwfdkalefidkar-sangkvlvhclaGisrsatv VVAYLMIFHNMAILEALMTVRKKR-AIYPNEGFLKQLRELNEK .| .|.. || |..|| .| || || || | ... aiayimktlemsldeayrfvkekrptispnlnflgqLleyeke |
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| Phosphatase | DUSP27.AA | Subfamily.PTPMT1.PD | 179-260 | 28 | 3e-08 | 23.8 | In-house | 48-128 (146) | Show / Hide |
Range on Protein: 179-260 Range on HMM: 48-128/146 Sequence Identity: 28% (23 aa) YTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALlTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEALMTVRKKRA .. | ...| . . || |. .. ... ||... . . .| | | .||| || .||| .... || ...||| wkklGveqlqlatvDfteapslekleegvefiekva-skgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRp |
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