Gene DUPD1
DUPD1
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of DUPD1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | DUPD1.AA | Family.DSP.PD | 47-206 | 29 | 4.7e-34 | 109.1 | In-house | 99-253 (387) | Show / Hide |
Range on Protein: 47-206 Range on HMM: 99-253/387 Sequence Identity: 29% (48 aa) KGSPQYTHVNEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAhgrwnvdTGPDYYR-DMDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALsDDHSKILV . . ...|..|.||.| .| .. |...| |...|.. .... . . .|.|. . || .. .|. .| | ||. . |.....|| fervengkpseilphlylgsllaaknlewlkelgvtkivnlt-------ddkpqftkelgikylripidDhnapplenlfekaidfieegn-dskgvVlV HCVMGRSRSATLVLAYLMIHKDMTLVDAIQQVAKNR--CVLPNRGFLKQLRELDKQLVQQRRR || .|..||.||. |||| ....|| .|.. |.. | .. || |||||| .| |........ HCkaGkgRsgtliiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekeklkvsse |
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| Phosphatase | DUPD1.AA | Subfamily.DSP3.PD | 54-199 | 58 | 1e-70 | 227.2 | In-house | 1-148 (148) | Show / Hide |
Range on Protein: 54-199 Range on HMM: 1-148/148 Sequence Identity: 58% (87 aa) HVNEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHGRW--NVDTGPDYYRDMDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALSDDHSKILVHCVMGR .|.||.||.|.||||.| |. .|.| |.|||||||.|.. .|||....|.|..|.|.|||..|.|.|||| .|. || |||.|||....|.|||||.| evdevypkvyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGi SRSATLVLAYLMIHKDMTLVDAIQQVAKNRCVLPNRGFLKQLRELDKQ |||||||||||||....||..||..| |.|..|||.||||||.|||.. sRsatlvlayLmirrkltlkeaiktvrkkreilPneGflkqLleldek |
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| Phosphatase | DUPD1.AA | DSPc | 54-199 | 27 | 9.4e-34 | 119.37 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 54-199 Range on HMM: 1-172/172 Sequence Identity: 27% (48 aa) HVNEVWPKLYIGDEATAL--DRYRLQKAGFTHVLNAAHGRWN-----------VDTGPDYYRDMDIQYHGVE-ADD-------LPTFDLSVFFYPAAAFI . |. |.||.| . ... . |.| ..|||.|.. .. . . | . | . ..|| .. || .. ..| .| ...|| GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHY-TNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFI DRALSDDHSKILVHCVMGRSRSATLVLAYLMIHKDMTLVDAIQQV-----AKNR--CVLPNRGFLKQLRELDKQ ... .. |.|||| .| ||||||. |||| . |.. ||. | ..| ...|| .|..||.|. .. HDC-RQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
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| Phosphatase | DUPD1.AA | Subfamily.DSP19.PD | 55-198 | 40 | 5.2e-33 | 104.6 | In-house | 2-138 (139) | Show / Hide |
Range on Protein: 55-198 Range on HMM: 2-138/139 Sequence Identity: 40% (59 aa) VNEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHGRWNVdtgpdyYRdMDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALSDDhSKILVHCVMGRSRS | || |.||.| .| |. |.| . ||.|| | | || . |..| .| ||| .| .. | ||. |.| | .|||| |.||| vaevkprlylgsqdvaadkeilkklkitHilnvavgvpnv------fp-kdftyksieilDlpetkllsylkealdFieearskd-grvlvHCnAGvSRs ATLVLAYLMIHKDMTLVDAIQQVAKNR-CVLPNRGFLKQLRELDK |..|.|||| .....| .|...| ..| |. || ||.|||.|... asvviaylmkdeelslekalekvrearpcikPneGFikqLkeyea |
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| Phosphatase | DUPD1.AA | DSPc | 62-199 | 29 | 4.5e-31 | 109.96 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 62-199 Range on HMM: 1-151/151 Sequence Identity: 29% (47 aa) LYIGDEATAL-DRYRLQKAGFTHVLNAA-----HGRWNVDTGPDYYRDMDIQYHGVE-ADD---------LPTFDLSVFFYPAAAFIDRALSDDHSKILV ||.| . ... | ||| |.|||.|.. . . | . ...| .. .| .. ..| .| | .|||.. .. |.|| LYLGSYPHHMADPAFLQKHGITHVINCTMECPNN---------WFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDC-RQKGGKVLV HCVMGRSRSATLVLAYLMIHKDMTLVDAIQQV-----AKNR--CVLPNRGFLKQLRELDKQ || .| ||||.|..|||| . |.. .|. .| ..| .. || .|..||.|. .| HCQAGISRSACLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
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| Phosphatase | DUPD1.AA | Subfamily.DSP1.PD | 56-199 | 34 | 2.1e-30 | 96.4 | In-house | 3-139 (139) | Show / Hide |
Range on Protein: 56-199 Range on HMM: 3-139/139 Sequence Identity: 34% (49 aa) NEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHGrwnvdtGPDYYRDMdIQYHGVEADDLPTFDLSVFFYPAAAFIDRAlSDDHSKILVHCVMGRSRSA .|. . ||.| . | .. |.. . |..|| . |...... .|. .. .| .. |.| .|..|. |||.. . . ..||||.| ||||| veildfLyLGsaehasnlqlLkelkitallnvsae------lpnvfeel-fkyksipvednkkadisslfeeaidfidsv-kkkgGrvlvhCqaGisrsa TLVLAYLMIHKDMTLVDAIQQVAKNR-CVLPNRGFLKQLRELDKQ .|||||| .| ..| .| . | ..| .. || ||..|| | .|| tivlayLmkekkvrleeafefvkqrrsiisPnfgfvgqLlefekq |
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| Phosphatase | DUPD1.AA | Subfamily.DSP14.PD | 55-199 | 32 | 7e-30 | 94.7 | In-house | 2-138 (138) | Show / Hide |
Range on Protein: 55-199 Range on HMM: 2-138/138 Sequence Identity: 32% (47 aa) VNEVWPKLYIGdEATALDRYRLQKAGFTHVLNAAHgrwnvDTGPDYYRdmDIQYHGVEADDLPTFDLSVFFYPAAAFIDrALSDDHSKILVHCVMGRSRS ..|. ..||.. |.||.. |.|...|...|.. .. ... |... .. .| |. .|. .| ..|. |. ... .. |.|||||.|.||| lseitesLyls-gaaalkkeklkkkkitlivnvtt-----elpetkle--dvktvkikveDkpeaklaehfdevadkie-evkkkgGktlvhCvaGvsRs ATLVLAYLMIHKDMTLVDAIQQVAKNRC-VLPNRGFLKQLRELDKQ |.||||||| .. ..| .| . | ..| . || || |||....|. AslvlaylmkyeklsLreayklvksaRpiirPnvGFwkqlidyEkk |
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| Phosphatase | DUPD1.AA | Subfamily.DSP12.PD | 55-195 | 31 | 3.9e-29 | 92.4 | In-house | 2-137 (143) | Show / Hide |
Range on Protein: 55-195 Range on HMM: 2-137/143 Sequence Identity: 31% (45 aa) VNEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHGRWnvdtgPDYYRDMDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALsDDHSKILVHCVMGRSRS |.|. |.||.|. ... .| .|... |||| .. . |.. . . .. ....| |. || .. | .||. .| . . ..|||| .| ||| vseilpglylggleavqerellkelkithvlsvikeel-----pelqkekgvkskliqilDepeedlLshldeavrFieegl-ekegavlvHClagvSRS ATLVLAYLMIHKDMTLVDAIQQVAK-NRCVLPNRGFLKQLRE .|.|.|||| .... | .|.. | . .. . || |||.||. vtiviAYlmkkeklslekAlklvkekkkeiepNegFleQLkl |
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| Phosphatase | DUPD1.AA | Subfamily.DSP6.PD | 57-198 | 34 | 3.2e-27 | 85.7 | In-house | 4-140 (141) | Show / Hide |
Range on Protein: 57-198 Range on HMM: 4-140/141 Sequence Identity: 34% (49 aa) EVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHGRwnvdtgPDYYRD-MDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALSDDhSKILVHCVMGRSRSA |. |.||.| . .| .. |.| . .||| .. . |. ... ...|. . ..| . .|. || | .||| | |.. ||.||||| ||| |. eilpllylGsakdasnlevlkklkikyvlnvtsnl------pnkfeesgelkykqipiedhlsqnlakffPeaiefidearskk-skvlvhclaGvsrsv TLVLAYLMIHKDMTLVDAIQQVAK-NRCVLPNRGFLKQLRELDK .||||| .. ..| || . | | . . || |..|| . .. tvtlaylmkklalslndaydlvkkkksnisPnfnfmgqlldfer |
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| Phosphatase | DUPD1.AA | Subfamily.DSP10.PD | 56-198 | 32 | 4.7e-27 | 85.4 | In-house | 3-140 (141) | Show / Hide |
Range on Protein: 56-198 Range on HMM: 3-140/141 Sequence Identity: 32% (47 aa) NEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHgrwnvdTGPDY-YRDMDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALSDdHSKILVHCVMGRSRS .. | |..|.| | |. |.. | ..||| . . | . . . ...|. ... | .. .|. | | .||. | . |..|||| | |||| ssilpflllGnekdaadkdaldrlgikyvlnvtt------svPnffeekglvrykripvsdsgkqnlkqkfeealefieearkr-gsrvlvhchaGisrs ATLVLAYLMIHKDMTLVDAIQQVAKNRCV-LPNRGFLKQLRELDK |.|.||.| |....| .| . | ..| . || .|. || |..| atvviayvmkhlslslseaykfvkekrPiisPnlnfmGqllefek |
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| Phosphatase | DUPD1.AA | Subfamily.DSP15.PD | 55-198 | 37 | 2.5e-25 | 79.8 | In-house | 2-137 (138) | Show / Hide |
Range on Protein: 55-198 Range on HMM: 2-137/138 Sequence Identity: 37% (54 aa) VNEVWPKLYIGDEATALDRYRLQKAGFTHVLNAaHgrwnvDTGPDYYRDmdIQYHGVEADDLPTFDLSVFFYPAAAFIDRALSDDHsKILVHCVMGRSRS .|.| | ||.|. | |. .|.. ||.| | |. ..| |.| ..|.| | ||| || . || .. ... ..||||. | ||| mnkvlpGlyvGnfrdakdkeqleenkithilsi-h-----dsakplled--ikylcikaadsPdqdlskffkesidfihkcrlegg-nvlvhclaGisrs ATLVLAYLMIHKDMTLVDAIQQVAKNRCV-LPNRGFLKQLRELDK ||| ||.| ... ||.. | .| | || || .||.| .| vtlvvayimtvtelswedalkavkaarsvanPnvGfrrqlqefek |
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| Phosphatase | DUPD1.AA | Subfamily.Slingshot.PD | 57-195 | 32 | 6.1e-25 | 78.4 | In-house | 4-135 (139) | Show / Hide |
Range on Protein: 57-195 Range on HMM: 4-135/139 Sequence Identity: 32% (45 aa) EVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHgrwNVDtgpDYYRDmDIQYHGVEADDLPTFDLSVFFYPAAAFIDRAlSDDHSKILVHCVMGRSRSAT ... ||.| | | . |.. | ...|| .. ..| ... . ...|. . | .. || .. . ||..| ...||.|||| || ||||. kifdhlylGsewnasnleelkengveyilnvtk---eid---nffpe-kfkylnirvydeeetdllkhwnetykfieka-kekgskvlvhckmGvsrsas LVLAYLMIHKDMTLVDAIQQVAKNR-CVLPNRGFLKQLRE |.|| | . ...| .|.. | ..| .. ||.||||||.. tviayamkeyelsleealeyvkerrsiikpnkgflkqlkv |
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| Phosphatase | DUPD1.AA | Subfamily.LRR-DSP.PD | 57-198 | 34 | 9.9e-24 | 74.5 | In-house | 4-136 (137) | Show / Hide |
Range on Protein: 57-198 Range on HMM: 4-136/137 Sequence Identity: 34% (50 aa) EVWPKLYIGDEATALDRYRLQKAGFTHVLNAAhgrwnvDTGPdYYRDMdIQYHGVEADDLPTFDLSVFFYPAAAFIDRAlsDDHSKILVHCVMGRSRSAT .. .|||.| .| .. |.. . ||.| | | | .| |. ..| ....| . .|.. .| |||| .. .|.|| | ||||| liidklylgcresamnksilkdnnvthilava------dfkp-lypdl-fkyliidiedvdeadiyqhfkemnafideg--rekggvlihcragvsrsat LVLAYLMIHKDMTLVDAIQQVAKNRC-VLPNRGFLKQLRELDK ||.|||| .. ... .|.. | |.| . ||||||.||. .| lviaylmkknslkfkealdlvikkrpriypnrgfldqlkkfek |
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| Phosphatase | DUPD1.AA | Subfamily.DSP8.PD | 56-200 | 34 | 4.3e-22 | 69.4 | In-house | 3-142 (143) | Show / Hide |
Range on Protein: 56-200 Range on HMM: 3-142/143 Sequence Identity: 34% (49 aa) NEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHgrwNVDTGPDYYRdmDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALSdDHSKILVHCVMGRSRSA ... |.||.| . .||. |.| | ..|||... . . .. . . ... . | . .|. .| | |||.| | ..|.|||||.|||||. trilpnlylGsqkdsldeellkklgisyvlnise---scpkdvellk--esrflriPvkDkyeekllpwfdkalefidkars-angkvlvhclaGisrsa TLVLAYLMIHKDMTLVDAIQQVAKNR-CVLPNRGFLKQLRELDKQL ..||.| . .|.| .| . | . | . || || || | .|.| tvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekel |
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| Phosphatase | DUPD1.AA | Subfamily.STYX.PD | 55-197 | 28 | 7.7e-18 | 55.5 | In-house | 2-144 (146) | Show / Hide |
Range on Protein: 55-197 Range on HMM: 2-144/146 Sequence Identity: 28% (41 aa) VNEVWPKLYIGDEATALDR--YRLQKAGFTHVLNAAHGRWNVDTGPDYYRdmDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALSDdHSKILVHCVMGRS ..|. | |..| ..|. |.. | ||.. |.. ...| .. | .. .. .. . .||| .|. |.||| | | mqeilpglflgpysaamksklevlkehgithivcirqnieanlikpnfpd--rfrylvldvadntveniirylptvkefiddslqk-ggkvlvhgnagis RSATLVLAYLMIHKDMTLVDAIQQVAKNR-CVLPNRGFLKQLRELD |||.||.||.| . .| . | ..| |. || || .||.| . rsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeye |
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| Phosphatase | DUPD1.AA | Subfamily.STYXL1.PD | 60-198 | 28 | 1.7e-17 | 54.8 | In-house | 7-142 (143) | Show / Hide |
Range on Protein: 60-198 Range on HMM: 7-142/143 Sequence Identity: 28% (39 aa) P-KLYIGDEATALDRYRLQKAGFTHVLNAAhgrwnVDTGPDYYRDMD-IQYHGVEADDLPTFDLSVFFYPAAAFIDRALSdDHSKILVHCVMGRSRSATL | |||.|.. | .. . ..| . |... . . | . .. .| . || .. . ||.. . . .||| ||||....|| PgklylGnykqaqnpaikkdlkvkahvnvs-----sdaekliagladvakllhiavedeneadllerlkevvqfiekhkk-egevvlvfsnkGisrsaav VLAYLMIHKDMTLVDAIQQVAKNR-CVLPNRGFLKQLRELDK || .|..|| .| ... | . | |||.|..||.| .| iiaylmyskkitlkkaykylkkckenvkPnrafveqlseWek |
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| Phosphatase | DUPD1.AA | Subfamily.PTPMT1.PD | 110-183 | 36 | 3.2e-13 | 40.5 | In-house | 52-129 (146) | Show / Hide |
Range on Protein: 110-183 Range on HMM: 52-129/146 Sequence Identity: 36% (28 aa) GVEADDLPTFDLSV-----FFYPAAAFIDRALSDdHSKILVHCVMGRSRSATLVLAYLMIHKDMTLVDAIQQVAKNRCV ||| |.| |. . ||.. |. |.. ||| ||.|||||| .||| .| .. .|.. ..| | GveqlqlatvDfteapslekleegvefiekvask-gssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpq |
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| Phosphatase | DUPD1.AA | Subfamily.PTPDC1.PD | 132-182 | 38 | 3.9e-09 | 27.1 | In-house | 160-208 (229) | Show / Hide |
Range on Protein: 132-182 Range on HMM: 160-208/229 Sequence Identity: 38% (19 aa) IDRALsdDHSKILVHCVMGRSRSATLVLAYLMIHKDMTLVDAIQQVAKNRC .| || ..|| ||| |. | |. .||. .|..| .||..| ..| vdfal--eegkiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrp |
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| Phosphatase | DUPD1.AA | Subfamily.DSP23.PD | 140-181 | 35 | 1.2e-08 | 25.9 | In-house | 66-107 (128) | Show / Hide |
Range on Protein: 140-181 Range on HMM: 66-107/128 Sequence Identity: 35% (15 aa) HSKILVHCVMGRSRSATLVLAYLMIHKDMTLVDAIQQVAKNR . . |||..|. |. ||. ||. ..... ||| .| |.| eeavgvhcalGlGrtGtllacylvkeeglaaddaiaevrkrr |
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| Phosphatase | DUPD1.AA | Subfamily.R_Nematode_3.PD | 140-181 | 31 | 1.6e-08 | 25.0 | In-house | 198-245 (267) | Show / Hide |
Range on Protein: 140-181 Range on HMM: 198-245/267 Sequence Identity: 31% (15 aa) HSKILVHCVMGRSRSATLVLAYLMIHK------DMTLVDAIQQVAKNR . ..|||. | ||||||. . | . . ...|.. |... | | ktpvvVHCsdGisRsatlaaielgyqliikskgkldllslikelrkqR |
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| Phosphatase | DUPD1.AA | Subfamily.PTEN.PD | 129-178 | 26 | 6.6e-08 | 23.0 | In-house | 82-133 (305) | Show / Hide |
Range on Protein: 129-178 Range on HMM: 82-133/305 Sequence Identity: 26% (13 aa) AAFIDRALSDDHSKI-LVHCVMGRSRSATLVLAYLMIHKDMTLV-DAIQQVA .|. |. |.|.. ||| .|. |. ... |||. .. .. .|.. . vedvdkwLkedksnVvavHCkaGkGRtGvmicayLlksgikksadealaiyd |
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| Phosphatase | DUPD1.AA | Subfamily.RNGTT.PD | 140-182 | 35 | 1.8e-07 | 21.7 | In-house | 79-121 (140) | Show / Hide |
Range on Protein: 140-182 Range on HMM: 79-121/140 Sequence Identity: 35% (15 aa) HSKILVHCVMGRSRSATLVLAYLMIHKDMTLVDAIQQVAKNRC .. | ||| | | |..|||. ..|... .|.. ||.| devigvhCthGfnrtGflivayLvekedwsveaavalfakarp |
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| Phosphatase | DUPD1.AA | Subfamily.DSP11.PD | 126-196 | 26 | 6.5e-07 | 20.0 | In-house | 68-138 (141) | Show / Hide |
Range on Protein: 126-196 Range on HMM: 68-138/141 Sequence Identity: 26% (18 aa) YPAAAFIDRAlSDDHSKILVHCVMGRSRSATLVLAYLMIHKDMTLVDAIQQVAKNRCVL-PNRGFLKQLREL |... |. . | ||| | |. |. ||. .... |||.. . | .|..|..| eavkeflekn-kdndkligvhCthGvnrtGyliCrylidvegyspedaieafeearGhslerenyledLkkl |
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| Phosphatase | DUPD1.AA | Subfamily.Laforin.PD | 99-173 | 27 | 1.2e-06 | 19.1 | In-house | 64-137 (165) | Show / Hide |
Range on Protein: 99-173 Range on HMM: 64-137/165 Sequence Identity: 27% (19 aa) DYYRDMDIQYHGVEADDLPTfDLSVFFYPAAAFIDRALSDDHSKILVHCVMGRSRSATLVLAYLMIHKDMTLVDA |.. . | . .|| | . | | | .. || .. .. ||| | ||...| .|. . .| klykeeglayiwlptedlst-esrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakv |
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| Phosphatase | DUPD1.AA | Subfamily.PRL.PD | 138-193 | 33 | 3.2e-06 | 17.8 | In-house | 79-133 (140) | Show / Hide |
Range on Protein: 138-193 Range on HMM: 79-133/140 Sequence Identity: 33% (19 aa) DDHSKILVHCVMGRSRSATLVlAYLMIHKDMTLVDAIQQVAKNRCVLPNRGFLKQL ...| . |||| | |. || | .| . |. ||.. . ..| |. || | epkstvavhcvaGlGraPvlv-alalieaGmkyedavefirekrrgainskqlkfl |
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| Phosphatase | DUPD1.AA | Subfamily.CDC14.PD | 140-175 | 37 | 3.2e-06 | 17.8 | In-house | 198-233 (258) | Show / Hide |
Range on Protein: 140-175 Range on HMM: 198-233/258 Sequence Identity: 37% (13 aa) HSKILVHCVMGRSRSATLVLAYLMIHKDMTLVDAIQ . .| ||| | | .||. .||..| .| ..| eGaiavhCkaGLGrtgtligcylikhyrftaaetia |
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