Gene EPM2A
EPM2A
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of EPM2A.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| CBM_20 | EPM2A.AA | CBM_20 | 19-116 | 25 | 6.5e-07 | 25.19 | Pfam | 20-103 (103) | Show / Hide |
Range on Protein: 19-116 Range on HMM: 20-103/103 Sequence Identity: 25% (27 aa) ELLVVGSRPELGRWEPRGAVRLRPAGT-AAGDGALALQEPGLWLG-EVELAAEEAAQDGAEPGRVDTFWYKFLKREPGG-ELSWEGNGPHHD----RCCT .. .||. |||| | | |..| . . ... .| | | |.| ||.||..|.. .| ||. || . .|| NVYIVGNIPELGNWNPANAIKLSWNQYDTSSY--------PTWYGQTVSLPAGT------------TFEYKYIKKDSDGQNVTWES-GPNRWYTVPSSCT YNENN . . GTTTT |
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| Phosphatase | EPM2A.AA | Family.DSP.PD | 140-330 | 21 | 2.4e-23 | 73.8 | In-house | 90-256 (387) | Show / Hide |
Range on Protein: 140-330 Range on HMM: 90-256/387 Sequence Identity: 21% (42 aa) KHTTDFYFNIAGHQAMHYSRILPNIWLGSCPRQveHVTIKLkHELGITAVMNFQtewdivqnssgcnrY------PepmtpdtmiklyrEEGLAYIWMPT . . | | . .. . |.|||...|||. .. . . .| .|||.|.. | . . |.| .|..| . tfdldtydhfervengkpseilphlylgsllaa--knlewl-kelgvtkivnlt--------------ddkpqftk-------------elgikylripi PDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYIDEEALARAQEDFFQKFGKVRSSVCS | ... ... .|. .. .... |.|||.||.|||. .. .| . .|..| . ... ||| | . .. . .|. .. ||.|.|. dDhnapplenlfekaidfieegndskgvVlVHCkaGkgRsgtliiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekeklkvssevme |
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| Phosphatase | EPM2A.AA | Subfamily.Laforin.PD | 156-320 | 78 | 1.1e-108 | 351.0 | In-house | 1-165 (165) | Show / Hide |
Range on Protein: 156-320 Range on HMM: 1-165/165 Sequence Identity: 78% (129 aa) HYSRILPNIWLGSCPRQVEHVTIKLKHELGITAVMNFQTEWDIVQNSSGCNRYPEPMTPDTMIKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHAL |||.||.|||||||||.||||||.||.|||||||...|||.|||.||||..||.|..||.|..|||.||||||||.||.|.|||.||..|||||.||||| hyskileniwlgscprlvehvtidlkselgitavislqtesdivknssgiyrynenltpitlkklykeeglayiwlptedlstesrvenlpqavyllhal LEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYIDEEALARAQEDFFQK ||||||||||||||||||||.|||.||||.||.|.||||||.||||.||||||||.||..||||| lekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvvyideealiraekdffqk |
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| Phosphatase | EPM2A.AA | Subfamily.PTPMT1.PD | 218-310 | 25 | 3.6e-18 | 56.6 | In-house | 45-137 (146) | Show / Hide |
Range on Protein: 218-310 Range on HMM: 45-137/146 Sequence Identity: 25% (23 aa) IKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYIDEEAL . ....|. .. ..| |. .. | ..| ... .||. ||||| || .||.. | .| . .. . . || .||| . . .. . teewkklGveqlqlatvDfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlkskqw |
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| Phosphatase | EPM2A.AA | Subfamily.DSP12.PD | 230-307 | 29 | 2.2e-11 | 34.8 | In-house | 52-129 (143) | Show / Hide |
Range on Protein: 230-307 Range on HMM: 52-129/143 Sequence Identity: 29% (23 aa) WMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYIDE .. |. .| .. |..|| .. |||. |.|||.||| || ..| .| . ...|.| .. .|.. .. | liqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiviAYlmkkeklslekAlklvkekkkeiepNe |
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| Phosphatase | EPM2A.AA | Subfamily.DSP19.PD | 226-303 | 26 | 2.2e-10 | 31.4 | In-house | 46-123 (139) | Show / Hide |
Range on Protein: 226-303 Range on HMM: 46-123/139 Sequence Identity: 26% (21 aa) LAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAV . | .. | . . ...|..|. .. ..|. .|.||||||| ||.. | ..| .|.| . ..||.. ftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylmkdeelslekalekvrearpci |
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| Phosphatase | EPM2A.AA | Subfamily.PTPDC1.PD | 181-302 | 24 | 2.4e-10 | 31.0 | In-house | 94-209 (229) | Show / Hide |
Range on Protein: 181-302 Range on HMM: 94-209/229 Sequence Identity: 24% (29 aa) KHELGITAVMNFQTEWDIVQNSSGCNRYPEPMTPDTmiklYREEGLAYIWMPTPDMSTEGRVQMLpQAVCLLHALLEKGHIVyVHCNAGVGRSTAAVCGW .| ||.||.| |.. . . .| .. .|. . ..|... .. .| .. ..| . | .. ||.|.| ||| |||| .. .| fkesGikavinLqeagehahCGagleesGfsYdpee----lmrqgiyfynfglkDygvasleriL-divkvvdfaleegkia-vHCHAGlGRtGvliacy LQYVMGWNLRKVQYFLMAKRPA |. . . .. .||| lvyakrltaeeaiklvrskrpk |
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| Phosphatase | EPM2A.AA | Subfamily.STYX.PD | 216-306 | 25 | 4e-10 | 30.5 | In-house | 43-133 (146) | Show / Hide |
Range on Protein: 216-306 Range on HMM: 43-133/146 Sequence Identity: 25% (23 aa) TMIKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYID ..|| .. . |. . | ..| .. ||.. .. |.|| | || |||. ||.| | ... .| . |. .. .| . . nlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpn |
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| Phosphatase | EPM2A.AA | DSPc | 164-290 | 21 | 2.3e-09 | 34.52 | Pfam | 1-116 (151) | Show / Hide |
Range on Protein: 164-290 Range on HMM: 1-116/151 Sequence Identity: 21% (29 aa) IWLGSCPRQVEHVTIKLKHELGITAVMNFQTEWDIVQNSSGCNRYPEPMTPDTMIKLYREEGLAYIWMP-TPD---------MSTEGRVQMLPQAVCLLH ..|||.|.. . ..|||.|.| ..| . .| .. |.|.| | . .. .| .|.|. .. LYLGSYPHHM--ADPAFLQKHGITHVINCTMECPNN-------------------WFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFID ALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLR .. .||. |.|||.||. || . .. .| . ...... DCRQKGGKVLVHCQAGISRSACLCIAYLMKYRNMSYN |
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| Phosphatase | EPM2A.AA | Subfamily.DSP10.PD | 217-303 | 23 | 4.6e-09 | 27.1 | In-house | 39-125 (141) | Show / Hide |
Range on Protein: 217-303 Range on HMM: 39-125/141 Sequence Identity: 23% (20 aa) MIKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAV . . .. . | .| | ... | . .|. .. ..| | |||.||. ||.. | .. .. |.. |. |||.. PnffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvviayvmkhlslslseaykfvkekrPii |
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| Phosphatase | EPM2A.AA | Subfamily.DSP6.PD | 214-292 | 24 | 6.7e-09 | 26.3 | In-house | 36-114 (141) | Show / Hide |
Range on Protein: 214-292 Range on HMM: 36-114/141 Sequence Identity: 24% (19 aa) PDTMIKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKV .. | ... | | .| | .. ...|.|. .. .| | ||| ||| || . . .| . | . snlpnkfeesgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtlaylmkklalslnda |
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| Phosphatase | EPM2A.AA | Subfamily.DSP3.PD | 212-285 | 25 | 9.1e-08 | 22.9 | In-house | 41-115 (148) | Show / Hide |
Range on Protein: 212-285 Range on HMM: 41-115/148 Sequence Identity: 25% (18 aa) MTPDTMIKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLH-ALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVM .. || . |.. .. |. .. |. . . .|. .. || .|. |.|||..|. ||.. | .| lkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisRsatlvlayLmirr |
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| Phosphatase | EPM2A.AA | Subfamily.DSP1.PD | 223-301 | 26 | 9.2e-08 | 23.0 | In-house | 43-121 (139) | Show / Hide |
Range on Protein: 223-301 Range on HMM: 43-121/139 Sequence Identity: 26% (21 aa) EEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRP || . | ..| | ... ... .|. .... .|| |.|||.||. ||.. | .| ..|.. |. .| eelfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayLmkekkvrleeafefvkqrrs |
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| Phosphatase | EPM2A.AA | DSPc | 156-320 | 20 | 2.6e-07 | 24.25 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 156-320 Range on HMM: 1-172/172 Sequence Identity: 20% (38 aa) HYSRILPNIWLGSCPRQVEHVTIKLKHELGITAVMNFQTEWD-------IVQNSSGCNRYPEPMTPDTMIKLYREEGLAYIWMP-TPD-------MSTEG |.|.|...|||.|...| .. ...||.|.| . | . . | | .| . |...| | . .. GPSEITPHLYLGSYPHHMEP-NPCFLKKHNITHVINVTMECPWNFHHCQK-----------NDMHY-TNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTN RVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFL-----MAKRPAVYIDEE-ALARAQEDFFQK .| .|... .|.. ||. |.||| ||. || . .. .| . |..... .|. .| | . . . .. .| ISQYFPEVYDFIHDCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRR-CPIICPNFNFWHQLCEWERK |
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| Phosphatase | EPM2A.AA | Subfamily.Slingshot.PD | 219-303 | 20 | 4.5e-07 | 20.6 | In-house | 39-123 (139) | Show / Hide |
Range on Protein: 219-303 Range on HMM: 39-123/139 Sequence Identity: 20% (17 aa) KLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAV . . .| ..|. . | ... .. .. ... ||| | ||| || ||...| . ...| . .. .| . dnffpekfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviayamkeyelsleealeyvkerrsii |
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| Phosphatase | EPM2A.AA | Subfamily.DSP15.PD | 226-300 | 21 | 1.3e-06 | 19.2 | In-house | 45-119 (138) | Show / Hide |
Range on Protein: 226-300 Range on HMM: 45-119/138 Sequence Identity: 21% (16 aa) LAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKR . | .. | .. . ... ..|. .|. |.||| ||. ||.. | .. | .. ... . | | ikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayimtvtelswedalkavkaar |
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| Phosphatase | EPM2A.AA | Subfamily.DSP8.PD | 227-303 | 22 | 1.4e-06 | 19.2 | In-house | 49-125 (143) | Show / Hide |
Range on Protein: 227-303 Range on HMM: 49-125/143 Sequence Identity: 22% (17 aa) AYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAV .. .| | .| ......|. . .. | ||| || ||.. . ... . .| . |. |||.. rflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaiayimktlemsldeayrfvkekrpti |
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| Phosphatase | EPM2A.AA | Subfamily.LRR-DSP.PD | 228-305 | 25 | 1.6e-06 | 18.8 | In-house | 47-123 (137) | Show / Hide |
Range on Protein: 228-305 Range on HMM: 47-123/137 Sequence Identity: 25% (20 aa) YIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHiVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYI |. . |. | . . .... ||| | .|| ||| ||...| .| .... . . ||| .| yliidiedvdeadiyqhfkemnafidegrekgg-vlihcragvsrsatlviaylmkknslkfkealdlvikkrpriyp |
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| Phosphatase | EPM2A.AA | Subfamily.DSP14.PD | 225-303 | 21 | 2.2e-06 | 18.6 | In-house | 44-122 (138) | Show / Hide |
Range on Protein: 225-303 Range on HMM: 44-122/138 Sequence Identity: 21% (17 aa) GLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAV ..... .. |.... . . ... .... .|| . ||| ||| || . | .| .||. .. ..|| . dvktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlaylmkyeklsLreayklvksaRpii |
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| Phosphatase | EPM2A.AA | Subfamily.STYXL1.PD | 243-296 | 27 | 5.6e-06 | 17.4 | In-house | 67-120 (143) | Show / Hide |
Range on Protein: 243-296 Range on HMM: 67-120/143 Sequence Identity: 27% (15 aa) QMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFL . | ..| ... ..|..| | | |. ||.|.. ..| | ..|.| .| erlkevvqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykyl |
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