Gene STYXL1
STYXL1
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of STYXL1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Rhodanese | STYXL1.AA | RHOD | 17-140 | 14 | 8.3e-15 | 56.44 | SMART | 1-94 (94) | Show / Hide |
Range on Protein: 17-140 Range on HMM: 1-94/94 Sequence Identity: 14% (18 aa) NQATKLSRLTDPNYLCLLDVRSKWEYDESHVITALRVKKKNNEYLLPESVDLECVKYCVVYDNNSSTLEILLKDDDDDSDSDGDGKDLVPQAAIEYGRIL . .. .| . . ....|.|.. ||...|. |. . ..... .. |. .||. . . | . ..| V-PEWWKMLQN-EDCVIIDCRWPYEYEGGHIPGAINIPWDELLDR----LGIDKDKPVIVYCRSGNRS------------------------APRAAWWL TRLTHHPVYILKGGYERFSGTYHF ... ...||||.||.. .. .. REAGYKNVYILDGGWKEWKRACPP |
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| Phosphatase | STYXL1.AA | Subfamily.STYXL1.PD | 159-299 | 55 | 4.8e-71 | 227.7 | In-house | 1-143 (143) | Show / Hide |
Range on Protein: 159-299 Range on HMM: 1-143/143 Sequence Identity: 55% (79 aa) YPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDAD--KLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAA ||.|..|||...||..||..|.|.||||.|||||||.|.....||.|| |||||..||..||..|..|.....||| |.. |.|.|.||..|||||.|. yPvevlPgklylGnykqaqnpaikkdlkvkahvnvssdaekliagladvakllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaav IIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEKT ||||||.|...||.....|.||||.|..|||..|.|| ||||. iiaylmyskkitlkkaykylkkckenvkPnrafveqlseWekq |
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| Phosphatase | STYXL1.AA | Subfamily.DSP1.PD | 160-298 | 33 | 6.4e-27 | 84.5 | In-house | 2-138 (139) | Show / Hide |
Range on Protein: 160-298 Range on HMM: 2-138/139 Sequence Identity: 33% (46 aa) PIEIVpGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAgDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIA | ||. ...| ..| . .. |.||| | .||| .. |. . | .| .||...|.|. ..... .||. .. | .|. .||||| . ..| pveil-dfLyLGsaehasnlqlLkelkitallnvsaelpnvfe-elfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativla YLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEK |||.... .|. .. .||. .. . || |.| ||||.|| yLmkekkvrleeafefvkqrrsiisPnfgfvgqLlefek |
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| Phosphatase | STYXL1.AA | Subfamily.DSP19.PD | 163-298 | 32 | 1.1e-25 | 80.3 | In-house | 4-138 (139) | Show / Hide |
Range on Protein: 163-298 Range on HMM: 4-138/139 Sequence Identity: 32% (43 aa) IVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDAdKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLM | ....| . | | .| | ||| .||.... .|. | . ..| | | ||...| .|.... ||| .. . ..|. |.|||. .|||||.. evkprlylgsqdvaadkeilkklkitHilnvavgvpnvfpkdf-tyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylm HSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEK .| .|... .|.. . ...|| | . || |.|. kdeelslekalekvrearpcikPneGFikqLkeyea |
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| Phosphatase | STYXL1.AA | Subfamily.DSP6.PD | 159-298 | 31 | 1.1e-24 | 76.9 | In-house | 1-140 (141) | Show / Hide |
Range on Protein: 159-298 Range on HMM: 1-140/141 Sequence Identity: 31% (44 aa) YPIEIVPgKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDA-DKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAI .|.||.| ....|. .|.. .. |.|||| .||. . .|. . | ..| ||| .... |. . .||. .. | .|. |.||| . . lpveilp-llylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvt IAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEK .||||.... .|. ....||| | |..|| .. |||..|. laylmkklalslndaydlvkkkksnisPnfnfmgqlldfer |
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| Phosphatase | STYXL1.AA | Subfamily.DSP14.PD | 168-298 | 27 | 3.7e-24 | 75.5 | In-house | 9-137 (138) | Show / Hide |
Range on Protein: 168-298 Range on HMM: 9-137/138 Sequence Identity: 27% (36 aa) VFVGnFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDADkLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQ .... . | ... | || . |||.... . | . ..|..||.|||.. ... ... || .. | .|.. ..|.||| . ..||||. .. Lyls-gaaalkkeklkkkkitlivnvttelpetkledvk-tvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlaylmkyekl TLQRSWAYVKKCKNNMCPNRGLVSQLLEWEK .|. .. .||.... ..|| | .|| ..|| sLreayklvksaRpiirPnvGFwkqlidyEk |
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| Phosphatase | STYXL1.AA | Subfamily.DSP12.PD | 164-299 | 28 | 4.5e-23 | 72.1 | In-house | 5-141 (143) | Show / Hide |
Range on Protein: 164-299 Range on HMM: 5-141/143 Sequence Identity: 28% (39 aa) VPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDA-DKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLM . .....|. ... ... .|.|||.. . | . | . .. | . | | |.||. .| .| ....||| . . .|. . |.|||...|||||. ilpglylggleavqerellkelkithvlsvikeelpelqkekgvkskliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiviAYlm HSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEKT ... |.. ||. |....|| | ..|| .|| kkeklslekAlklvkekkkeiepNegFleQLklfekm |
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| Phosphatase | STYXL1.AA | Subfamily.DSP10.PD | 167-298 | 30 | 6e-23 | 71.5 | In-house | 8-140 (141) | Show / Hide |
Range on Protein: 167-298 Range on HMM: 8-140/141 Sequence Identity: 30% (40 aa) KVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDADK-LLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSN ...|| .| | .. . | || .|| . || .. .. .| ..||.. .. . .||| .. ||..|. . |||||...|||.|. .. flllGnekdaadkdaldrlgikyvlnvttsvPnffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvviayvmkhl EQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEK .|. .. .||. . ..|| ... ||||.|| slslseaykfvkekrPiisPnlnfmGqllefek |
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| Phosphatase | STYXL1.AA | Family.DSP.PD | 161-302 | 30 | 1.4e-22 | 70.7 | In-house | 108-249 (387) | Show / Hide |
Range on Protein: 161-302 Range on HMM: 108-249/387 Sequence Identity: 30% (42 aa) IEIVPgKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAY || | ....|....| . . |.|.... ||.. | | | |.| |.|... .. .. . ||| .. ..|.|. ..|..||||||||.| seilp-hlylgsllaaknlewlkelgvtkivnltddkpqftkelgikylripidDhnapplenlfekaidfieegndskgvVlVHCkaGkgRsgtliiaY LMHSNEQTLQRSWAYVKKCKN-NMCPNRGLVSQLLEWEKTILG . ||. ....|..... . || | ..|| ..|| .| lmksegltleealdwvrskRpgvitpnqgflkqlkdlekeklk |
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| Phosphatase | STYXL1.AA | Subfamily.LRR-DSP.PD | 161-298 | 34 | 1.7e-22 | 69.9 | In-house | 3-136 (137) | Show / Hide |
Range on Protein: 161-298 Range on HMM: 3-136/137 Sequence Identity: 34% (47 aa) IEIVPgKVFVGNFSQACDPKIQKDLKIkAHVNVSMDTGPFFAgDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSViLIFSTQGISRSCAAIIAY .|.. |...| | . | ||... .|. | |.. | | | | ||| .||.| ....| ||. . | | || |.|||....|||| dliid-klylgcresamnksilkdnnv-thilavadfkplyp-dlfkyliidiedvdeadiyqhfkemnafidegrekggv-lihcragvsrsatlviay LMHSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEK |. |. ..... |.| .... ||||.. ||. .|| lmkknslkfkealdlvikkrpriypnrgfldqlkkfek |
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| Phosphatase | STYXL1.AA | Subfamily.DSP8.PD | 166-300 | 27 | 3.9e-22 | 68.9 | In-house | 7-142 (143) | Show / Hide |
Range on Protein: 166-300 Range on HMM: 7-142/143 Sequence Identity: 27% (37 aa) GKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGP-FFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHS ....| .. | .. |.| | .|.|. . ..|.| ..|. | ..||.. . ..||. .. . .|.. ||||| ..|||.|. | pnlylGsqkdsldeellkklgisyvlnisescpkdvellkesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaiayimkt NEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEKTI .|. .. .||. .. . || . ||||.||.. lemsldeayrfvkekrptispnlnflgqLleyekel |
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| Phosphatase | STYXL1.AA | Subfamily.Slingshot.PD | 167-297 | 30 | 4e-21 | 65.5 | In-house | 8-137 (139) | Show / Hide |
Range on Protein: 167-297 Range on HMM: 8-137/139 Sequence Identity: 30% (39 aa) KVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDAdKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNE ...| |.. . |. ... .||. . ||... | |.||. |..|...|.. . .||| .. || .|. |.|||...||| |.. | . hlylGsewnasnleelkengveyilnvtkeidnffpekf-kylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviayamkeye QTLQRSWAYVKKCKNNMCPNRGLVSQLLEWE |.....|||. .. . ||.|...|| ..| lsleealeyvkerrsiikpnkgflkqlkvye |
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| Phosphatase | STYXL1.AA | DSPc | 168-299 | 21 | 1.7e-20 | 73.19 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 168-299 Range on HMM: 1-151/151 Sequence Identity: 21% (32 aa) VFVGNFSQAC-DPKIQKDLKIKAHVNVSMDTGP--FFAGDADKLLHIR-IED---------SPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSC ...|... . || ... ..|.. .|..| . |... ..| ..| .....| .... ||. . | .|. . ||||| LYLGSYPHHMADPAFLQKHGITHVINCTMECPNNWFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRSA AAIIAYLMHSNEQTLQRSWAYV-----KKCK-NNMCPNRGLVSQLLEWEKT . .||||| .. ... ...| |. . ...|| .. ||.|.|. CLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
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| Phosphatase | STYXL1.AA | DSPc | 160-299 | 21 | 2.4e-18 | 68.21 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 160-299 Range on HMM: 1-172/172 Sequence Identity: 21% (37 aa) PIEIVPGKVFVGNFSQAC--DPKIQKDLKIKAHVNVSM-DTGPFF---------------AGDADKLLHIR-IED-------SPEAQILPFLRHMCHFIE .. ........|. . . .| .| ..|.. .||.| .. .|. .. .|| |.| .....|.... ||. GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH IHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYV-----KKCK-NNMCPNRGLVSQLLEWEKT . | .|. ||||| . .|||||... ... ....| |. . . .||| ... ||.|||.. DCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
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| Phosphatase | STYXL1.AA | Subfamily.DSP15.PD | 163-298 | 30 | 4.6e-18 | 55.7 | In-house | 5-137 (138) | Show / Hide |
Range on Protein: 163-298 Range on HMM: 5-137/138 Sequence Identity: 30% (41 aa) IVPGkVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGdaDKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLM ..|| ..|||| .| | . .. || . . .. |.. . | | |...|||. .. |.. .|| |. .|. |||||. ..||.| vlpG-lyvGnfrdakdkeqleenkithilsihdsakplled--ikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayim HSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEK | . . . || .. || |. .|| |.|| tvtelswedalkavkaarsvanPnvGfrrqlqefek |
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| Phosphatase | STYXL1.AA | Subfamily.DSP3.PD | 167-297 | 30 | 5.2e-16 | 49.0 | In-house | 8-146 (148) | Show / Hide |
Range on Protein: 167-297 Range on HMM: 8-146/148 Sequence Identity: 30% (43 aa) KVFVGNFSQACDPKIQKDLKIKAHVNV-------SMDTGPFFAGD-ADKLLHIRIEDSPEAQILPFLRHMCHFIEIH-HHLGSVILIFSTQGISRSCAAI ||.||. . | | . | | | .| ..||.. | | | | . ..|.||... . .. .||. .. .. .|. ...||||| . . kvyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisRsatlv IAYLMHSNEQTLQRSWAYVKKcKNNMCPNRGLVSQLLEWE .|||| ... ||. . |.| | .. ||.|...|||| . layLmirrkltlkeaiktvrk-kreilPneGflkqLleld |
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| Phosphatase | STYXL1.AA | Subfamily.STYX.PD | 162-297 | 31 | 7.2e-15 | 45.3 | In-house | 4-144 (146) | Show / Hide |
Range on Protein: 162-297 Range on HMM: 4-144/146 Sequence Identity: 31% (44 aa) EIVPGkVFVGNFSQACDPKIQKDLK--IKAHVNVSMD-----TGPFFAgDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSC ||.|| .|.| .| | |... . | | . . | | | . | . . |.. .|. .| .. .||. . | .|.|||||.| .| eilpg-lflgpysaamksklevlkehgithivcirqnieanlikpnfp-drfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsa AAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWE ||.| . . ..|||.. . . || |.|||| |.| alviayimetyglkyreafayvqerrfcinpnegfvsqlkeye |
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| Phosphatase | STYXL1.AA | Subfamily.PTPMT1.PD | 209-283 | 25 | 2.3e-08 | 24.1 | In-house | 56-130 (146) | Show / Hide |
Range on Protein: 209-283 Range on HMM: 56-130/146 Sequence Identity: 25% (19 aa) LHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNM |.. . | || | |.. .||| ....|| . . | .|| . ...|||.... . . .. ..||..... lqlatvDfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqi |
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