Gene PTP4A3
PTP4A3
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of PTP4A3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | PTP4A3.AA | Subfamily.PRL.PD | 17-155 | 65 | 5.5e-71 | 228.4 | In-house | 1-139 (140) | Show / Hide |
Range on Protein: 17-155 Range on HMM: 1-139/140 Sequence Identity: 65% (91 aa) MRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVA .||||...|...|...||| |||. ...||||||..|| . |...||.|.|..|||||.|| .||..||.|.|.||.|.|.|.||||||||||||||||| lrflildepsdetvekfieelkkenvkevvrvcepsydaeklkeegievldlafddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlva LALIESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPK |||||.|||||||..|||.|||||||||||..||||..| lalieaGmkyedavefirekrrgainskqlkflekykak |
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| Phosphatase | PTP4A3.AA | Family.DSP.PD | 23-155 | 28 | 1.9e-24 | 78.2 | In-house | 117-246 (387) | Show / Hide |
Range on Protein: 23-155 Range on HMM: 117-246/387 Sequence Identity: 28% (40 aa) HNPTNAtlsTFIEDLKKYGATTVVRVCevtYDKTPLEK-DGITVVDWPFDDGAPPPGKVVedWLSLVKakFCEA---PGSCVAVHCVAGLGRAPVLVALA .. .| . | ||..| | .|... .||. .| ||.....|.||. .|| . . . .. |.| ....|.||| ||.|| ..|.. | gsllaa---knlewlkelgvtkivnlt---ddkpqftkelgikylripidDhnapplenl--fekaid--fieegndskgvVlVHCkaGkgRsgtliiaY LIES-GMKYEDAIQFIRQKRRGAINSK--QLTYLEKYRPK ..| |...|.|....|.||.| |. . .| .|.... . lmksegltleealdwvrskRpgvitpnqgflkqlkdleke |
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| Phosphatase | PTP4A3.AA | Subfamily.CDC14.PD | 31-151 | 29 | 5.7e-22 | 70.1 | In-house | 137-253 (258) | Show / Hide |
Range on Protein: 31-151 Range on HMM: 137-253/258 Sequence Identity: 29% (35 aa) STFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKfceapGSCVAVHCVAGLGRAPVLVALALI-ESGMKYEDA ...| .| . ||.||. . ||.. .. |. .| | ||. |. .... .|... .|||| ||||| .|.. ||. ... ...| eklleyfrknnvttivrLnkklYdakkftdaGfahlDlffiDGtvPsdailkkfleiteka-----eGaiavhCkaGLGrtgtligcylikhyrftaaet IQFIRQKRRGAINSKQLTYLEK ..| | | . ..| |||.. iawlriarPGsvigpqqtylve |
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| Phosphatase | PTP4A3.AA | Subfamily.PTPDC1.PD | 51-147 | 31 | 3.7e-15 | 47.5 | In-house | 123-218 (229) | Show / Hide |
Range on Protein: 51-147 Range on HMM: 123-218/229 Sequence Identity: 31% (30 aa) VTYDKTPLEKDGITVVDWPFDDGAPPPgkvVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALI-ESGMKYEDAIQFIRQKRRGAINSKQ-LT .||. | . ||.. ....| .. .| | .|| . .|||| ||||| ||.| |. . .. |.||...|.||.|.... . fsYdpeelmrqgiyfynfglkDygvas---leriLdivkvvdfaleegkiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrpksiqtreqve |
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| Phosphatase | PTP4A3.AA | Subfamily.DSP23.PD | 61-145 | 30 | 3.2e-12 | 38.2 | In-house | 32-115 (128) | Show / Hide |
Range on Protein: 61-145 Range on HMM: 32-115/128 Sequence Identity: 30% (26 aa) DGITVVDWPFDDGAPPPGKVVEDWLSLVKAkfCEAPGSCVAVHCVAGLGRAPVLVALALIE-SGMKYEDAIQFIRQKRRGAINSKQ ...|.. .| || . |. .. .|. |. . |.|||. ||||. |.| |.. |. .||| .|..|.|.|.... psltlrridipdfcPPaleqvarlvrivee--aekkeeavgvhcalGlGrtGtllacylvkeeglaaddaiaevrkrrkGsietve |
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| Phosphatase | PTP4A3.AA | Subfamily.PTEN.PD | 62-138 | 36 | 7.6e-11 | 33.4 | In-house | 59-137 (305) | Show / Hide |
Range on Protein: 62-138 Range on HMM: 59-137/305 Sequence Identity: 36% (27 aa) GITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALIESGMKYE--DAIQFIRQKRR | |||| ||. ...|. . |. | ||||| || ||. |... |..||.| . .|... .|| dgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavHCkaGkGRtGvmicayLlksgikksadealaiydekRt |
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| Phosphatase | PTP4A3.AA | Subfamily.RNGTT.PD | 50-150 | 27 | 2.3e-10 | 31.9 | In-house | 31-131 (140) | Show / Hide |
Range on Protein: 50-150 Range on HMM: 31-131/140 Sequence Identity: 27% (27 aa) EVTYDKTPLEKDGITVVDWPF-DDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALIES-GMKYEDAIQFIRQKRRGAINSKQlt . ||| |||.|.. . | | . .. ...||| ... |.. ..||| | |. |.. |.| .. |.|.. . || .. ||. sryydkeelekegvkyiklqcrGrGeaPtkeqtklfiklvkeflkkkPdevigvhCthGfnrtGflivayLvekedwsveaavalfakarppGiyked-- YLE ylk |
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| Phosphatase | PTP4A3.AA | Subfamily.PTPMT1.PD | 58-153 | 27 | 2.7e-10 | 31.8 | In-house | 48-144 (146) | Show / Hide |
Range on Protein: 58-153 Range on HMM: 48-144/146 Sequence Identity: 27% (27 aa) LEKDGITVVDWPFDDGAP-PPGKVVEDWLSLVKAKfcEAPGSCVAVHCVAGLGRAPVLVALALI-ESGMKYEDAIQFIRQKRRGA-INSKQLTYLEKYR .| |.. . . | . | . .|. ..... . ||.| ||| || .|. ||| |. . .. |.|..|...||. ..|||.. |.... wkklGveqlqlatvDfteapslekleegvefiekv--askgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlkskqwralqefk |
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| Phosphatase | PTP4A3.AA | Subfamily.R_Nematode_3.PD | 90-148 | 29 | 1.6e-08 | 25.8 | In-house | 191-257 (267) | Show / Hide |
Range on Protein: 90-148 Range on HMM: 191-257/267 Sequence Identity: 29% (20 aa) AKFCEAPGSCVAVHCVAGLGRAPVLVALAL-----IE--SGMKYEDAIQFIRQKRRGAINSK-QLTY .||.|. . | |||..| .|. .|.| | |. . ... . |. .|..| |||... .|.. ikfveksktpvvVHCsdGisRsatlaaielgyqliikskgkldllslikelrkqRagaiqtelelaf |
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| Phosphatase | PTP4A3.AA | Subfamily.DSP1.PD | 93-138 | 34 | 7.2e-08 | 24.1 | In-house | 75-121 (139) | Show / Hide |
Range on Protein: 93-138 Range on HMM: 75-121/139 Sequence Identity: 34% (16 aa) CEAPGSCVAVHCVAGLGRAPVLVALALI-ESGMKYEDAIQFIRQKRR ... | | ||| ||. |. .| . |. |. ...|.| .|..|.| vkkkgGrvlvhCqaGisrsativlayLmkekkvrleeafefvkqrrs |
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| Phosphatase | PTP4A3.AA | Subfamily.N13.PD | 64-145 | 26 | 8.3e-08 | 23.6 | In-house | 161-245 (259) | Show / Hide |
Range on Protein: 64-145 Range on HMM: 161-245/259 Sequence Identity: 26% (23 aa) TVVDWPfDDGAPPPGKVVEDWLSLVKaKFCEaPGSCVAVHCVAGLGRAPVLVALA----LIE--SGMKYEDAIQFIRQKRRGAINSKQ |.|| | | | . . .. |. .. . . ..||| ||.||. ||... ||| .. .. .. .|..|.| . .|. nfvkwP-dhgvPssaaelvqfvaevr-llqt-dagPivvhcsaGiGrsGvlitidvvlglierdkefdvkeivrklreqrqgvvqtkd |
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| Phosphatase | PTP4A3.AA | Subfamily.DSP3.PD | 96-149 | 31 | 8.8e-08 | 23.7 | In-house | 88-142 (148) | Show / Hide |
Range on Protein: 96-149 Range on HMM: 88-142/148 Sequence Identity: 31% (17 aa) PGSCVAVHCVAGLGRA-PVLVALALIESGMKYEDAIQFIRQKRRGAINSKQLTYL .. | ||||.|. |. . .| .| .. ..||. .|.|| |. |. | kngkvlvhcvvGisRsatlvlayLmirrkltlkeaiktvrkkreilPneGflkqL |
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| Phosphatase | PTP4A3.AA | Subfamily.DSP11.PD | 79-143 | 25 | 1e-07 | 23.4 | In-house | 61-128 (141) | Show / Hide |
Range on Protein: 79-143 Range on HMM: 61-128/141 Sequence Identity: 25% (17 aa) KVVEDWLSLVKAKF--CEAPGSCVAVHCVAGLGRAPVLVALALIE-SGMKYEDAIQFIRQKRRGAINS ..|... . || .. .. ..||| |. |. |. ||. |.. ||||. . | ... edvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyspedaieafeearGhsler |
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| Phosphatase | PTP4A3.AA | Subfamily.N_Nematode_1.PD | 65-141 | 30 | 2e-07 | 22.1 | In-house | 170-247 (265) | Show / Hide |
Range on Protein: 65-141 Range on HMM: 170-247/265 Sequence Identity: 30% (25 aa) VVDWPfDDGAPPPGKVVEDWLSLVKAKfcEAPgscVAVHCVAGLGRAPVLVALALIESGMK-------YEDAIQFIRQKRRGAI ||| | |.|| . . |. |... ..| ..||| ||.||. .||...| . |. .. ||..|. .| WtdWP-drGvPpadlaalelleavrgs--kgP---ivvhCsaGiGrtGtivaieyildkllegkqiedmeklvkkireqrnysi |
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| Phosphatase | PTP4A3.AA | Subfamily.DSP8.PD | 93-150 | 27 | 3e-07 | 22.1 | In-house | 77-133 (143) | Show / Hide |
Range on Protein: 93-150 Range on HMM: 77-133/143 Sequence Identity: 27% (16 aa) CEAPGSCVAVHCVAGLGRAPV-LVALALIESGMKYEDAIQFIRQKRrgAINSKQLTYLE ... ..| ||| || |.. .| . . |....| .|...|| . |..| .|. arsangkvlvhclaGisrsatvaiayimktlemsldeayrfvkekr--ptispnlnflg |
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| Phosphatase | PTP4A3.AA | Subfamily.RB.PD | 64-132 | 27 | 4.2e-07 | 21.2 | In-house | 160-228 (261) | Show / Hide |
Range on Protein: 64-132 Range on HMM: 160-228/261 Sequence Identity: 27% (18 aa) TVVDWPfDDGAPPPGKVVEDWLSLVKAKFCEA-PGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQF . || | | | | . |.. |. . .. . . ||| ||.||. . .|| . .. .| . hftsWp-dhgvPektktlldfvrtvreaiekkaskkPivvHCsaGvGRtGtfialdrllqaieendyvdv |
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| Phosphatase | PTP4A3.AA | Subfamily.RA.PD | 64-132 | 29 | 5.4e-07 | 20.8 | In-house | 166-233 (266) | Show / Hide |
Range on Protein: 64-132 Range on HMM: 166-233/266 Sequence Identity: 29% (19 aa) TVVDWPfDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQF || . | | || . . | ||.. . . ..||| || ||. ...| . .| |. .. hftswp-evGvpaegkGmlkllkkvkklqqqsanhpivvhcsaGvGrtGtfivldavlervkaerkldv |
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| Phosphatase | PTP4A3.AA | Subfamily.Slingshot.PD | 95-140 | 31 | 7.8e-07 | 20.6 | In-house | 77-123 (139) | Show / Hide |
Range on Protein: 95-140 Range on HMM: 77-123/139 Sequence Identity: 31% (15 aa) APGSCVAVHCVAGLGR-APVLVALALIESGMKYEDAIQFIRQKRRGA . || | ||| |. | | ...| |. | ....|.|.......|. . ekgskvlvhckmGvsrsastviayamkeyelsleealeyvkerrsii |
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| Phosphatase | PTP4A3.AA | Subfamily.STYX.PD | 93-143 | 32 | 7.9e-07 | 20.6 | In-house | 82-132 (146) | Show / Hide |
Range on Protein: 93-143 Range on HMM: 82-132/146 Sequence Identity: 32% (17 aa) CEAPGSCVAVHCVAGLGRAPVLVALALIES-GMKYEDAIQFIRQKRrGAINS . | | || ||. |. || ..|. |.|| .| ......| ||. slqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerr-fcinp |
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| Phosphatase | PTP4A3.AA | PTPc_motif | 64-155 | 18 | 1e-06 | 24.87 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 64-155 Range on HMM: 1-92/92 Sequence Identity: 18% (19 aa) TV-----VDWPFD----DGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQFIRQKRRGAINSK-QLTYLEKYR || .|| .|.| . . ... .|.. . ||| || ||. ...|. .. . . .. .. .|. |.|.. .. | .. . TVHHYHYTNWPDHVEKDSGVPE--DSILEFIRHVRK--------PIVVHCSAGCGRTGTFCAIDMMMQQVDIFQTVKEMRKQRPGMVQTEEQYIFCYRCI PK . LE |
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| Phosphatase | PTP4A3.AA | Subfamily.DSP19.PD | 98-140 | 30 | 1.2e-06 | 19.9 | In-house | 80-123 (139) | Show / Hide |
Range on Protein: 98-140 Range on HMM: 80-123/139 Sequence Identity: 30% (13 aa) SCVAVHCVAGLGRAP-VLVALALIESGMKYEDAIQFIRQKRRGA .| ||| || |.. | .| . .. ...|.|.. .|..|. . grvlvHCnAGvSRsasvviaylmkdeelslekalekvrearpci |
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| Phosphatase | PTP4A3.AA | Subfamily.DSP15.PD | 93-140 | 34 | 1.3e-06 | 19.9 | In-house | 74-122 (138) | Show / Hide |
Range on Protein: 93-140 Range on HMM: 74-122/138 Sequence Identity: 34% (17 aa) CEAPGSCVAVHCVAGLGRAPVLV-ALALIESGMKYEDAIQFIRQKRRGA | |. | |||.||. |. || | . . ...|||.. ... | | crleggnvlvhclaGisrsvtlvvayimtvtelswedalkavkaarsva |
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| Phosphatase | PTP4A3.AA | Subfamily.DSP10.PD | 97-138 | 35 | 1.7e-06 | 19.5 | In-house | 81-123 (141) | Show / Hide |
Range on Protein: 97-138 Range on HMM: 81-123/141 Sequence Identity: 35% (15 aa) GSCVAVHCVAGLGRA-PVLVALALIESGMKYEDAIQFIRQKRR || | ||| ||. |. | .| . .. ..| .|...|| gsrvlvhchaGisrsatvviayvmkhlslslseaykfvkekrP |
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| Phosphatase | PTP4A3.AA | Subfamily.R_Anemone_2.PD | 46-133 | 25 | 1.9e-06 | 19.2 | In-house | 142-233 (262) | Show / Hide |
Range on Protein: 46-133 Range on HMM: 142-233/262 Sequence Identity: 25% (23 aa) VRVCEVTYDKTPLEKD--GITVVDWPfDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQ---FI .| .|. ... |.. . .|| | |.| | . | . |.. |. ....||| ||.||. | .|. . .| |. .. lrsfkvkrteeeeerqvrqfhytsWp-degvpesgaslldlvrqvekaqqesgagpivvhcsaGvGrtGvfiavdillerikaealvdvfqtv |
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| Phosphatase | PTP4A3.AA | Subfamily.N12.PD | 67-129 | 31 | 3e-06 | 18.1 | In-house | 171-231 (270) | Show / Hide |
Range on Protein: 67-129 Range on HMM: 171-231/270 Sequence Identity: 31% (19 aa) DWPfDDGAPPPGKVVEDWLSLVKaKFCEAPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDA .|| | | | | . . ..||. .. |. . ..||| || ||. ...|. .. . .| | aWP-DhgvPssaksllelielvr-elqesedaPlvvhCsaGvGrtGtiiaidyvrellkaeki |
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| Phosphatase | PTP4A3.AA | Subfamily.DSP12.PD | 97-140 | 24 | 3.3e-06 | 18.8 | In-house | 81-125 (143) | Show / Hide |
Range on Protein: 97-140 Range on HMM: 81-125/143 Sequence Identity: 24% (11 aa) GSCVAVHCVAGLGRA-PVLVALALIESGMKYEDAIQFIRQKRRGA . | ||| ||. | . .| . ..... |.|......|.. . egavlvHClagvSRSvtiviAYlmkkeklslekAlklvkekkkei |
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| Phosphatase | PTP4A3.AA | Subfamily.R_Ecdysozoa.PD | 89-134 | 34 | 4.1e-06 | 17.7 | In-house | 193-238 (269) | Show / Hide |
Range on Protein: 89-134 Range on HMM: 193-238/269 Sequence Identity: 34% (16 aa) KAKFCEAPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQFIR | . | . ||| || ||. ..|||.|. .| || .. .. klnklsgsrsPivvhCsaGvgrsgifvaldlllqqlkaedkvdife |
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| Phosphatase | PTP4A3.AA | Subfamily.DSP6.PD | 95-138 | 31 | 8e-06 | 17.1 | In-house | 79-123 (141) | Show / Hide |
Range on Protein: 95-138 Range on HMM: 79-123/141 Sequence Identity: 31% (13 aa) APGSCVAVHCVAGLGRA-PVLVALALIESGMKYEDAIQFIRQKRR | | ||| ||. |. | .| . . . .|| .....|. skkskvlvhclaGvsrsvtvtlaylmkklalslndaydlvkkkks |
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| Phosphatase | PTP4A3.AA | Subfamily.N3.PD | 64-122 | 31 | 8.4e-06 | 16.7 | In-house | 162-222 (261) | Show / Hide |
Range on Protein: 64-122 Range on HMM: 162-222/261 Sequence Identity: 31% (19 aa) TVVDWPfDDGAPPPGKVVEDWLSLVKAkFCEAPGSCVAVHCVAGLGRAPVLVALAL----IES ..|| | | | . . .... |.. .. . | ||| ||.||. ||..| . ||. qylaWp-dhgvPddsadflefvervrk-lrsgkeePvvvhCsaGigrtGvlilletalaliea |
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