Gene PTPMT1
PTPMT1
Species: Human
Alias: PLIP, PTPMT1, MOSP, PNAS-129, DUSP23, FLJ46081
External Links:
COSMIC
,
Entrez Gene
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of PTPMT1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | PTPMT1.AA | Family.DSP.PD | 38-188 | 28 | 1.4e-28 | 91.1 | In-house | 107-249 (387) | Show / Hide |
Range on Protein: 38-188 Range on HMM: 107-249/387 Sequence Identity: 28% (42 aa) YHRIDPTVLLGALPLRSLTRQLvQDENVRGVITMNeeyetrflCNSSQEWKRLGVEQLRLSTVDMtGIPTLDN-LQKGVQFALKYQSLGQCVYVHCKAGR ..| | . || | . . .| .. .| .. .. ....|. |.||.. ||.. | . |.|.| ..| ..| . .. ...|.||||||.. pseilphlylgsllaaknlewl-kelgvtkivnlt--------ddkpqftkelgikylripidDh-napplenlfekaidfieegndskgvVlVHCkaGk SRSATMVAAYLIQVHKWSPEEAVRAIAKIRS-YIHIRPGQLDVLKEFHKQITA ||.|...|||.. .... |||.. ... |. | . |.| ||.. |.. gRsgtliiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekeklk |
|||||||||
| Phosphatase | PTPMT1.AA | Subfamily.PTPMT1.PD | 40-185 | 56 | 1.8e-66 | 213.3 | In-house | 1-146 (146) | Show / Hide |
Range on Protein: 40-185 Range on HMM: 1-146/146 Sequence Identity: 56% (82 aa) RIDPTVLLGALPLRSLTRQLVQDENVRGVITMNEEYETRFLCNSSQEWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRS ||| ||.|||||.||||..||..|||..|...|||||...|.||..|||.||||||.|.|||.|..|.|..|..||.| |..|.|..|||||||||.|| ridetvilGalPfrsltkeLvekenvkavvslneeyelkalansteewkklGveqlqlatvDfteapslekleegvefiekvaskgssvYvHCkAGrtRs ATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHKQ ||.||.||.. .|.||||||....|.|..|... |...|.||... atlvacylmkkkklspeeavkflkkkRpqirlkskqwralqefkek |
|||||||||
| Phosphatase | PTPMT1.AA | Subfamily.DSP12.PD | 40-184 | 28 | 7.8e-21 | 65.5 | In-house | 4-140 (143) | Show / Hide |
Range on Protein: 40-184 Range on HMM: 4-140/143 Sequence Identity: 28% (42 aa) RIDPTVLLGALPLRSLtRQLVQDENVRGVITMNEEYEtrflcnsSQEWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRS .|.| ..|| |. |.| .. .. |... .| .. |. ||... .. .|. . |..|.. |.| . . .. |.|||.|| ||| eilpglylggleavqe-rellkelkithvlsvikeel-------pelqkekgvkskliqilDepeedlLshldeavrFieeglekegavlvHClagvSRS ATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHK .|.|.|||.. .|.| |.|.... .... |. | |. || |.| vtiviAYlmkkeklslekAlklvkekkkeiepNegFleQLklfek |
|||||||||
| Phosphatase | PTPMT1.AA | Subfamily.DSP19.PD | 93-183 | 30 | 9.3e-17 | 52.0 | In-house | 47-137 (139) | Show / Hide |
Range on Protein: 93-183 Range on HMM: 47-137/139 Sequence Identity: 30% (28 aa) EQLRLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFH . . .. .| |. |.. ..| . .| . .|.|||.||.||||..| |||.. .. | |.|.. . . | |. | . |||.. tyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylmkdeelslekalekvrearpcikPneGFikqLkeye |
|||||||||
| Phosphatase | PTPMT1.AA | Subfamily.STYXL1.PD | 54-184 | 22 | 1.4e-14 | 45.3 | In-house | 18-142 (143) | Show / Hide |
Range on Protein: 54-184 Range on HMM: 18-142/143 Sequence Identity: 22% (29 aa) SLTRQLVQDENVRGVITMNEEYETrfLCNSSQEwkrlGVEQLRLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKW . ... .| |.... . . | | .. .. .. |... | |..|.. ||| |.. |..| | . | ||||....|||. .|. aqnpaikkdlkvkahvnvssdaek--liaglad----vakllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaaviiaylmyskki SPEEAVRAIAKIRSYIHIRPGQLDVLKEFHK . ..| . | .. .. . . .. |.|. | tlkkaykylkkckenvkPnrafveqlseWek |
|||||||||
| Phosphatase | PTPMT1.AA | DSPc | 128-185 | 32 | 2.1e-14 | 51.98 | Pfam | 88-151 (151) | Show / Hide |
Range on Protein: 128-185 Range on HMM: 88-151/151 Sequence Identity: 32% (21 aa) VYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAI-----AKIR-SYIHIRPGQLDVLKEFHKQ |.|||.|| ||||....|||.. ...| .|| . . . | . | ..... | |. .| VLVHCQAGISRSACLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
|||||||||
| Phosphatase | PTPMT1.AA | Subfamily.DSP1.PD | 56-184 | 28 | 3.7e-14 | 43.7 | In-house | 19-138 (139) | Show / Hide |
Range on Protein: 56-184 Range on HMM: 19-138/139 Sequence Identity: 28% (37 aa) TRQLVQDENVRGVITMNEEYETRFlcNSSQEWKRLGVEqlrlstvDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSP .||...... .. . .| . | ... ..|.. || | . . ... ..| . .. | |.|||.|| |||||.| |||.. .|.. | nlqlLkelkitallnvsaelpnvf--eelfkyksipve-------dnkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayLmkekkvrl EEAVRAIAKIRSYIHIRPGQLDVLKEFHK || . . || | | . | ||.| eeafefvkqrrsiisPnfgfvgqLlefek |
|||||||||
| Phosphatase | PTPMT1.AA | Subfamily.DSP8.PD | 39-184 | 28 | 1.6e-13 | 41.6 | In-house | 3-140 (143) | Show / Hide |
Range on Protein: 39-184 Range on HMM: 3-140/143 Sequence Identity: 28% (41 aa) HRIDPTVLLGALpLRSLTRQLVQDENVRGVITMNEEYETRFLCNSSQEWKRLGVEqlrlstvDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSR .|| | . ||. || ..|... .. |. . |. . . ... |. |. | |. ..| ..| | .| ..| ||| ||.|| trilpnlylGsq-kdsldeellkklgisyvlnisescpkdvellkesrflriPvk-------DkyeekllpwfdkalefidkarsangkvlvhclaGisr SATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHK |||.. ||... . | .|| | . . |. | |. | |..| satvaiayimktlemsldeayrfvkekrptispnlnflgqLleyek |
|||||||||
| Phosphatase | PTPMT1.AA | Subfamily.DSP15.PD | 92-184 | 32 | 1.8e-13 | 41.4 | In-house | 45-137 (138) | Show / Hide |
Range on Protein: 92-184 Range on HMM: 45-137/138 Sequence Identity: 32% (30 aa) VEQLRLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHK .. |... | . ... ..| | . |. |.||| || ||| |.|.||.. | ..| |.|..|. || . | |.||.| ikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayimtvtelswedalkavkaarsvanPnvGfrrqlqefek |
|||||||||
| Phosphatase | PTPMT1.AA | Subfamily.DSP3.PD | 124-178 | 42 | 1e-12 | 39.0 | In-house | 88-141 (148) | Show / Hide |
Range on Protein: 124-178 Range on HMM: 88-141/148 Sequence Identity: 42% (22 aa) LGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSyIHIRPGQLDV . |.|||..| |||||.| |||. .| . .||.... | |. | | | kngkvlvhcvvGisRsatlvlayLmirrkltlkeaiktvrkkre-ilPneGflkq |
|||||||||
| Phosphatase | PTPMT1.AA | Subfamily.DSP23.PD | 58-167 | 20 | 1.3e-12 | 38.8 | In-house | 7-108 (128) | Show / Hide |
Range on Protein: 58-167 Range on HMM: 7-108/128 Sequence Identity: 20% (22 aa) QLVQDENVRGVITMNEEYETRFLCNSSQEWKRLgveqlrlsTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEE | . |. .| .... .| .. . | ..|. .. |.|. ... |. . . .. | ||| |. |. |..| ||.. .. . .. qfladqGirvlvslttegapyseaapsltlrri--------dipdfcPPaleqvarlvriveeaekkeeavgvhcalGlGrtGtllacylvkeeglaadd AVRAIAKIRS |. . | | aiaevrkrrk |
|||||||||
| Phosphatase | PTPMT1.AA | Subfamily.Slingshot.PD | 95-182 | 34 | 1.3e-12 | 38.5 | In-house | 49-136 (139) | Show / Hide |
Range on Protein: 95-182 Range on HMM: 49-136/139 Sequence Identity: 34% (30 aa) LRLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEF |... | . |.. .. .| | .. | | |||| | ||||. | || .. ...| |||.. . . || |. | |. ||.. lnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviayamkeyelsleealeyvkerrsiikpnkgflkqlkvy |
|||||||||
| Phosphatase | PTPMT1.AA | Subfamily.DSP14.PD | 119-182 | 34 | 1.9e-12 | 38.2 | In-house | 72-135 (138) | Show / Hide |
Range on Protein: 119-182 Range on HMM: 72-135/138 Sequence Identity: 34% (22 aa) LKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEF . .. | .. |||.||.||||..| |||.. .| | .|| ... . |. |. .| | .. eevkkkgGktlvhCvaGvsRsAslvlaylmkyeklsLreayklvksaRpiirPnvGFwkqlidy |
|||||||||
| Phosphatase | PTPMT1.AA | Subfamily.DSP10.PD | 96-170 | 31 | 1.8e-11 | 34.9 | In-house | 52-126 (141) | Show / Hide |
Range on Protein: 96-170 Range on HMM: 52-126/141 Sequence Identity: 31% (23 aa) RLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIH |. | . . .... ..| . .. |. | |||.|| |||||.| ||... . | .|| . . . | | ripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvviayvmkhlslslseaykfvkekrPiis |
|||||||||
| Phosphatase | PTPMT1.AA | Subfamily.Laforin.PD | 86-170 | 28 | 4e-11 | 33.6 | In-house | 65-149 (165) | Show / Hide |
Range on Protein: 86-170 Range on HMM: 65-149/165 Sequence Identity: 28% (24 aa) EWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIH .| |. . | | |.. ..|| ..| . |. |||||.|| ||...| .| | .|| . | .. lykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvvy |
|||||||||
| Phosphatase | PTPMT1.AA | Subfamily.PTPDC1.PD | 125-186 | 27 | 4.7e-11 | 33.3 | In-house | 166-227 (229) | Show / Hide |
Range on Protein: 125-186 Range on HMM: 166-227/229 Sequence Identity: 27% (16 aa) GQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHKQI . ||| ||. | ..|.||. ... ..|||.. . . |. .|.....||.. . egkiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrpksiqtreqvelveeFalfl |
|||||||||
| Phosphatase | PTPMT1.AA | Subfamily.LRR-DSP.PD | 127-184 | 45 | 5.4e-11 | 33.3 | In-house | 79-136 (137) | Show / Hide |
Range on Protein: 127-184 Range on HMM: 79-136/137 Sequence Identity: 45% (26 aa) CVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHK | .||.|| |||||.| |||.. .. .||. . | |. |. .| || || | | gvlihcragvsrsatlviaylmkknslkfkealdlvikkrpriypnrgfldqlkkfek |
|||||||||
| Phosphatase | PTPMT1.AA | Subfamily.DSP6.PD | 56-171 | 21 | 1.3e-10 | 31.9 | In-house | 19-127 (141) | Show / Hide |
Range on Protein: 56-171 Range on HMM: 19-127/141 Sequence Identity: 21% (24 aa) TRQLVQDENVRGVITMNEEYETRFLCNSSQEWKRLGVEQLRlsTVDMTgiptlDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSP ...... ... |. . .. . | . . ..|.. .| . ... . . ..| . .| . | ||| || ||| |.. |||.. .. | . nlevlkklkikyvlnvtsnlpnkfeesgelkykqipiedhl--sqnla-----kffPeaiefidearskkskvlvhclaGvsrsvtvtlaylmkklalsl EEAVRAIAKIRSYIHI .| . | .| | ndaydlvkkkksnisP |
|||||||||
| Phosphatase | PTPMT1.AA | Subfamily.RNGTT.PD | 84-167 | 26 | 2.1e-10 | 31.2 | In-house | 36-121 (140) | Show / Hide |
Range on Protein: 84-167 Range on HMM: 36-121/140 Sequence Identity: 26% (22 aa) SQEWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALKYQ--SLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRS .| .. ||.. .| || .. .. .. .. . .. . ||| | | ...|||... .|| |.|| || | keelekegvkyiklqcrGrGeaPtkeqtklfiklvkeflkkkPdevigvhCthGfnrtGflivayLvekedwsveaavalfakarp |
|||||||||
| Phosphatase | PTPMT1.AA | Subfamily.DSP11.PD | 83-180 | 27 | 2.5e-10 | 31.1 | In-house | 36-136 (141) | Show / Hide |
Range on Protein: 83-180 Range on HMM: 36-136/141 Sequence Identity: 27% (27 aa) SSQEWKRLGVEQLRLSTVDMtGIPTLDNLQ---KGVQ-FALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDV . .|.. ||. .| .. .| .... . |. | | . .. . ||| | |. .. |||.|. .|||.|..| ..| .| |. || kkkeltdegvkykklncpGh-evpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyspedaieafeearGhslerenyled LK Lk |
|||||||||
| Phosphatase | PTPMT1.AA | Subfamily.CDC14.PD | 59-164 | 23 | 5.6e-10 | 30.1 | In-house | 142-237 (258) | Show / Hide |
Range on Protein: 59-164 Range on HMM: 142-237/258 Sequence Identity: 23% (24 aa) LVQDENVRGVITMNEEyetrflCNSSQEWKRLGVEQLRLSTVDMTgIPTLDNLQKGVQFALKYqslGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEA ...||. .. .|.. .... |.. | | .| | .|. |.| .. . | . |||||| | .|....|||... . .|.. yfrknnvttivrLnkk------lYdakkftdaGfahlDlffiDGt-vPsdailkkfleiteka---eGaiavhCkaGLGrtgtligcylikhyrftaaet VRAIAK . iawlri |
|||||||||
| Phosphatase | PTPMT1.AA | Subfamily.PTEN.PD | 124-166 | 38 | 2.1e-09 | 27.9 | In-house | 93-136 (305) | Show / Hide |
Range on Protein: 124-166 Range on HMM: 93-136/305 Sequence Identity: 38% (16 aa) LGQCVYVHCKAGRSRSATMVAAYLIQVHKW-SPEEAVRAIAKIR . | ||||||. |. .|..|||.. . |..||.. .. | ksnVvavHCkaGkGRtGvmicayLlksgikksadealaiydekR |
|||||||||
| Phosphatase | PTPMT1.AA | Subfamily.STYX.PD | 111-183 | 31 | 7.3e-08 | 23.2 | In-house | 72-144 (146) | Show / Hide |
Range on Protein: 111-183 Range on HMM: 72-144/146 Sequence Identity: 31% (23 aa) LQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFH | . .| . . | | || .|| ||||..| ||... . || . . . | | | . |||.. lptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeye |
|||||||||
| Phosphatase | PTPMT1.AA | Subfamily.TPIP.PD | 100-152 | 32 | 1.9e-07 | 21.7 | In-house | 10-64 (245) | Show / Hide |
Range on Protein: 100-152 Range on HMM: 10-64/245 Sequence Identity: 32% (17 aa) VDMTGIPTLDNLQKGVQFALKY--QSLGQCVYVHCKAGRSRSATMVAAYLIQVHK .| .|||..| . . . .. . | . | .||| |. | |.| |.||. iddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliasei |
|||||||||
| Phosphatase | PTPMT1.AA | Subfamily.PRL.PD | 122-184 | 31 | 4.3e-07 | 20.6 | In-house | 78-138 (140) | Show / Hide |
Range on Protein: 122-184 Range on HMM: 78-138/140 Sequence Identity: 31% (20 aa) QSLGQCVYVHCKAGRSRSATMVAAYLIQVhKWSPEEAVRAIAKIRSYiHIRPGQLDVLKEFHK .. ...| ||| || |. .|| ||. ..|.|| | . | | ||. |..... eepkstvavhcvaGlGraPvlvalaliea-Gmkyedavefirekrrg-ainskqlkflekyka |
|||||||||
| Phosphatase | PTPMT1.AA | Subfamily.R_Nematode_3.PD | 121-150 | 41 | 7.6e-07 | 19.5 | In-house | 194-224 (267) | Show / Hide |
Range on Protein: 121-150 Range on HMM: 194-224/267 Sequence Identity: 41% (12 aa) YQSLGQCVYVHCKAGRSRSATMVA-AYLIQV .. . | |||..| |||||..| . .| veksktpvvVHCsdGisRsatlaaielgyql |
|||||||||
| Phosphatase | PTPMT1.AA | DSPc | 50-185 | 13 | 7.7e-07 | 18.31 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 50-185 Range on HMM: 1-172/172 Sequence Identity: 13% (24 aa) LPLRSLTRQLVQDENVRGV---ITMNEEYETRFLCNSS-------------------------QEWKRLGVEQLRL-------STVDMTGIPTLDNLQKG | . . . | . . . . ..... . | . .. .... . .... . .... . GPSEITPH-LYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNI-SQYFPEVYDF VQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAI-----AKIR-SYIHIRPGQLDVLKEFHKQ .. . .. | |.|||.|| |||||...|||.. ...| ..| ... ..| . | ... |.|. .. IHDC---RQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
|||||||||