Gene RNGTT
RNGTT
Species: Human
Alias: hCAP, HCE1, DKFZp686J2031, HCE, RNGTT, CAP1A
External Links:
COSMIC
,
Entrez Gene
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of RNGTT.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | RNGTT.AA | Subfamily.CDC14.PD | 31-162 | 27 | 5.9e-13 | 39.3 | In-house | 119-241 (258) | Show / Hide |
Range on Protein: 31-162 Range on HMM: 119-241/258 Sequence Identity: 27% (33 aa) LGPRYDSQVAEE-NRFHPSMLSNYLKSLKVKMglLVDLTntSRFYDRNDIEKEGIKYIKLQCKgHGECPTTENTETFIRLCERFnernpPELIGVHCTHG ||. |.|.. . | | .| ....|. .| | .. ||.. ...|... | | .|... . |....|.| ||| | ||| || . agphnkskvedGytllaPeklleyfrknnvtt--ivrLn--kklYdakkftdaGfahlDlffi-DGtvPsdailkkfleiteka-----eGaiavhCkaG FNRTGFLICAFLVEKMDWSIEAAVATFAQARPP .|. . . . ..| . ||| LGrtgtligcylikhyrftaaetiawlriarPG |
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| MRNA_cap_enzyme | RNGTT.AA | mRNA_cap_enzyme | 272-460 | 42 | 4.90000000001e-154 | 369.09 | Pfam | 1-213 (213) | Show / Hide |
Range on Protein: 272-460 Range on HMM: 1-213/213 Sequence Identity: 42% (91 aa) QPVSMDK-QNIKLLDLKPYKVSWKADGTRYMMLIDGTNE------VFMIDRDNSVFHVSNLEFPFRKD-----LRMHLSNTLLDGEMIIDRVNGQ----A |||||.. .|.|.|. ..|.|.||.||.||||.|....| ..|||||....||.|..||.... |..|...|||||||.||....| . QPVSMSRRENMKFLKQNYYYVCWKTDGMRYMMFITDHPEYGEFKGCYMIDRDMNYYHVENMRFPCKYNKWGESLDKHHHYTLLDGEMCIDTIPMQETQCQ VPRYLIYDIIKFNSQP-VGDCDFN--VRLQCIEREIISPRHEKM--KTGLIDKTQEPFSVRNKPFFDICTSRKLL--EGNFAKEVSHEMDGLIFQPTG-K .|||||||....|.|. | ...|. |...|.||||.||...| ||........|||||.|...|...|.||. . .|.....||.||||||... . QPRYLIYDCVAINGQCRVMQWPFYSRKRWEMIKREIIKPRNHNMKFKTHWYRYDMFPFSVRFKDMWDNWHSEKLVYYFHKFIPHLCHEIDGLIFQCWDTP YKPGRCDDILKWK |.||||....||| YVPGRCQNLFKWK |
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| Phosphatase | RNGTT.AA | Subfamily.RNGTT.PD | 42-180 | 69 | 5e-74 | 236.9 | In-house | 2-140 (140) | Show / Hide |
Range on Protein: 42-180 Range on HMM: 2-140/140 Sequence Identity: 69% (96 aa) ENRFHPSMLSNYLKSLKVKMGLLVDLTNTSRFYDRNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNERNPPELIGVHCTHGFNRTGFLICAFL |..|.|.||..|||.||||.||..|||||||.||....||||.|||||||.|.||.||.|.|..||.|...|....| |.||||||||||||||||.|.| eeafepemlksylktlkvklglvidltntsryydkeelekegvkyiklqcrGrGeaPtkeqtklfiklvkeflkkkPdevigvhCthGfnrtGflivayL VEKMDWSIEAAVATFAQARPPGIYKGDYLKELFRRYGDI |||.|||.|||||.||.|||||||| |||||||.||.|. vekedwsveaavalfakarppGiykedylkelfkryedl |
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| Phosphatase | RNGTT.AA | Subfamily.DSP11.PD | 41-175 | 42 | 2.2e-40 | 128.0 | In-house | 2-137 (141) | Show / Hide |
Range on Protein: 41-175 Range on HMM: 2-137/141 Sequence Identity: 42% (58 aa) EENRFHPSMLSNYLKSLKVKMGLLVDLTNTSRFYDRNDIEKEGIKYIKLQCKGHgECPTTENTETFIRLCERFNE--RNPPELIGVHCTHGFNRTGFLIC ||.|| |. | . |.. . |.||..||||| |.|.......||.|| ||.| || | | .|. ..|.. ..| | . .|||||||||||||.||| eeerfapedlleklqeknkklGLvidltntdryykkkeltdegvkykklncpGh-evpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliC AFLVEKMDWSIEAAVATFAQARPPGIYKGDYLKELFR .|......| | |. .| .|| . . .||..| . rylidvegyspedaieafeearGhslerenyledLkk |
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| Phosphatase | RNGTT.AA | Family.DSP.PD | 53-174 | 30 | 1.1e-20 | 64.5 | In-house | 127-241 (387) | Show / Hide |
Range on Protein: 53-174 Range on HMM: 127-241/387 Sequence Identity: 30% (38 aa) YLKSLKVKMglLVDLTntsrfYDRNDIEK-EGIKYIKLQCKGHgECPTTENTetFIRLCErFNER--NPPELIGVHCTHGFNRTGFLICAFLVEKMDWSI || |.|.. |.|| .|.. ..| .||||..... | ..|. || |.. .. | | .. . . |||..| .|.| ||.|.|....... | wlkelgvtk--ivnlt-----ddkpqftkelgikylripidDh-napplenl--fekaid-fieegndskgvVlVHCkaGkgRsgtliiaYlmksegltl EAAVATFAQARPpGIYKG--DYLKELF .|.. ....|| |. . .||.|. eealdwvrskRp-gvitpnqgflkqlk |
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| Phosphatase | RNGTT.AA | Subfamily.DSP23.PD | 63-164 | 25 | 7.6e-12 | 35.7 | In-house | 16-111 (128) | Show / Hide |
Range on Protein: 63-164 Range on HMM: 16-111/128 Sequence Identity: 25% (26 aa) LLVDLTNTSRFYDRnDIEKEGIKYIklQCKGHgECPTTENTETFIRLCERFNERNppELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARPP ||.||. .. | .. ... | . . . |. | . ..|..| .... | .|||| |. ||| |. .||.. . . . |.| . |. vlvslttegapyse-aapsltlrri--dipdf-cPPaleqvarlvriveeaekke--eavgvhcalGlGrtGtllacylvkeeglaaddaiaevrkrrkG GI | si |
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| Phosphatase | RNGTT.AA | Subfamily.PRL.PD | 52-160 | 24 | 1.1e-10 | 31.8 | In-house | 16-121 (140) | Show / Hide |
Range on Protein: 52-160 Range on HMM: 16-121/140 Sequence Identity: 24% (27 aa) NYLKSLKVK-MGLLVDLTNTSrfYDRNDIEKEGIKYIKLQCKgHGECPTTENTETFIRLCERFNERNPPELIGVHCTHGFNRTGFLICAFLVEKmDWSIE .... || . . .| ..| || . ...|||. . |. . | |..| . ...|... ...| . ..||| |. |. |.. |.|. . | kfieelkkenvkevvrvceps--ydaeklkeegievldlafd-dGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlvalaliea-Gmkye AAVATFAQAR || . | davefirekr |
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| Phosphatase | RNGTT.AA | Subfamily.PTPMT1.PD | 77-161 | 25 | 5.9e-10 | 29.4 | In-house | 46-128 (146) | Show / Hide |
Range on Protein: 77-161 Range on HMM: 46-128/146 Sequence Identity: 25% (22 aa) NDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNERNppELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARP .. .|.|.....| . ..| |..|. | ... |...... . . ||| | | . |. ..|..| .| | || .... || eewkklGveqlqlatvDfteapslekleegvefiekvaskg--ssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRp |
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| Phosphatase | RNGTT.AA | Subfamily.PTEN.PD | 96-160 | 28 | 3.2e-09 | 26.8 | In-house | 71-136 (305) | Show / Hide |
Range on Protein: 96-160 Range on HMM: 71-136/305 Sequence Identity: 28% (18 aa) ECPTTENTETFIRLCERFNERNPPELIGVHCTHGFNRTGFLICAFLVEKMDWSIE-AAVATFAQAR || | |.... ... . . . . ||| | ||| .|||.|.... . . |.| ....| npptleLleeivedvdkwLkedksnVvavHCkaGkGRtGvmicayLlksgikksadealaiydekR |
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| Phosphatase | RNGTT.AA | Subfamily.PTPDC1.PD | 74-168 | 26 | 3.3e-09 | 26.8 | In-house | 125-215 (229) | Show / Hide |
Range on Protein: 74-168 Range on HMM: 125-215/229 Sequence Identity: 26% (25 aa) YDRNDIEKEGIKYIKLQCKGHGECPtTENTETFIRLCERFNERnppELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARPPGIYKGD || ... ..|| . . | .| .. |. . ... . | |.||| | ||| ||...|| . . . | |. . . |||. . YdpeelmrqgiyfynfglkDygvas-leriLdivkvvdfalee---gkiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrpksiqtre |
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| Phosphatase | RNGTT.AA | Subfamily.TPIP.PD | 97-144 | 28 | 5.1e-07 | 19.7 | In-house | 15-62 (245) | Show / Hide |
Range on Protein: 97-144 Range on HMM: 15-62/245 Sequence Identity: 28% (13 aa) CPTTENTETFIRLCERFNERNPPELIGVHCTHGFNRTGFLICAFLVEK || |. .| . . . .... ... .|| | .||| ..||.|.. vPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcallias |
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| Phosphatase | RNGTT.AA | Subfamily.DSP12.PD | 117-161 | 24 | 5.9e-07 | 19.9 | In-house | 79-123 (143) | Show / Hide |
Range on Protein: 117-161 Range on HMM: 79-123/143 Sequence Identity: 24% (11 aa) NPPELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARP . . . |||. | | .. |.|. | ..|.| |. . .... ekegavlvHClagvSRSvtiviAYlmkkeklslekAlklvkekkk |
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| Phosphatase | RNGTT.AA | Family.OCA.PD | 53-149 | 22 | 5e-06 | 16.5 | In-house | 27-121 (165) | Show / Hide |
Range on Protein: 53-149 Range on HMM: 27-121/165 Sequence Identity: 22% (22 aa) YLKSLKVKMGLLVDLTNTSRFYDRNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCER-FNERNPPelIGVHCTHGFNRTGFLIcAFLVEKMDWSI .|| || | . . ... . .|.| ||.| ...... . . . |. .|. . ...| | . .||..| .||| .. . | . |.. flktLkLktiislspeelpqesllkfveeeniklihikvdkkkkdlveieeellkrvlkilldvdnyp--vlihcnkGkhrtglvv-gclRklqkWnl |
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| Phosphatase | RNGTT.AA | Subfamily.OCA.PD | 53-149 | 23 | 5e-06 | 16.5 | In-house | 27-121 (165) | Show / Hide |
Range on Protein: 53-149 Range on HMM: 27-121/165 Sequence Identity: 23% (22 aa) YLKSLKVKMGLLVDLTNTSRFYDRNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCER-FNERNPPelIGVHCTHGFNRTGFLIcAFLVEKMDWSI .|| || | . . ... . .|.| ||.| ...... . . . |. .|. . ...| | . .||..| .||| .. . |. |.. flktLkLktiislspeelpqesllkfveeeniklihikvdkkkkdlveieeellkrvlkilldvdnyp--vlihcnkGkhrtglvv-gclRklqkWnl |
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| MRNA_cap_C | RNGTT.AA | mRNA_cap_C | 463-560 | 40 | 9.9e-54 | 189.62 | Pfam | 1-138 (138) | Show / Hide |
Range on Protein: 463-560 Range on HMM: 1-138/138 Sequence Identity: 40% (56 aa) SLNSVDFRLKITRM--GGE-GLL---PQNVGLL-YV-----------GGYERPF-------AQI--------KVTKELKQYDNKIIECKF--EN---NS- ..|.|||.||.... ||| |.| .|..|.| |. |||..|| ... |.|...|.|.|||.||.. .| . EMNTVDFMLKMCFECIGGEDGMLDRFQQWRGYLDYMEMPNFQKGRWWGGYNCPFFCKMYVFNKMRIFDIEWEKWTNDEKPYNNKIVECTWLVDNKQKGRP -WVFMRQRTDKSFPNAYNTAMAVCNSISNPVTKEMLFE |||||.|||||.|| .|||..||.||...||||.||| EWVFMRFRTDKSNPNHINTARKVCYSIEDNVTKEYLFE |
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