Gene SSH1
SSH1
Species: Human
Alias: FLJ38102, SSH1L, FLJ21928, KIAA1298, SSH1
External Links:
COSMIC
,
Entrez Gene
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of SSH1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| DEK_C | SSH1.AA | DEK_C | 251-304 | 35 | 3.5e-19 | 67.04 | Pfam | 1-56 (56) | Show / Hide |
Range on Protein: 251-304 Range on HMM: 1-56/56 Sequence Identity: 35% (20 aa) TERLIKAKLRSIMMSQDLENVTSKEIRNELEKQM-NCNLK-ELKEFIDNEMLLILG |.. ||...| |....||..||.|.|| .||... .|.|. . |.||..... .|. TDEQIKEEIREILRTADLMTVTMKQIRKQLEQRFPGCDLSKHRKAFIKEQIEEFLD |
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| Phosphatase | SSH1.AA | Subfamily.Slingshot.PD | 308-446 | 74 | 4.5e-77 | 247.1 | In-house | 1-139 (139) | Show / Hide |
Range on Protein: 308-446 Range on HMM: 1-139/139 Sequence Identity: 74% (103 aa) KPSLIFDHLYLGSEWNASNLEELQGSGVDYILNVTREIDNFFPGLFAYHNIRVYDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIAY |.| |||||||||||||||||||. .||.||||||.|||||||. |.|.||||||||.||||.||||.|.||.|||...||.|||||||||||||||||| kaskifdhlylGsewnasnleelkengveyilnvtkeidnffpekfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviay AMKEFGWPLEKAYNYVKQKRSITRPNAGFMRQLSEYEGI ||||... ||.|..|||..|||..||.||..||..|||| amkeyelsleealeyvkerrsiikpnkgflkqlkvyegi |
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| Phosphatase | SSH1.AA | DSPc | 308-446 | 30 | 3.6e-49 | 170.57 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 308-446 Range on HMM: 1-172/172 Sequence Identity: 30% (53 aa) KPSLIFDHLYLGSEWNAS--NLEELQGSGVDYILNVTREIDN-----------------FFPGLFAYHNIR-VYD-------EETTDLLAHWNEAYHFIN .|| | ||||||. .. |...|. ......|||.|... ... | | .| . | ...|.......|.| ||. GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH KAKRNHSKCLVHCKMGVSRSASTVIAYAMKEFGWPLEKAYNYV-----KQKR-SITRPNAGFMRQLSEYEGI ...... |.||||..|.||||. .||| || ...... ||..| ||.| .| .||..|..|| |.| . DCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
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| Phosphatase | SSH1.AA | Subfamily.DSP1.PD | 309-444 | 46 | 1.6e-46 | 148.3 | In-house | 2-137 (139) | Show / Hide |
Range on Protein: 309-444 Range on HMM: 2-137/139 Sequence Identity: 46% (63 aa) PSLIFDHLYLGSEWNASNLEELQGSGVDYILNVTREIDNFFPGLFAYHNIRVYDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIAYA |. | |.|||||. .||||. |. .. .|||..|..| |. || |..| | |....|......|| .||...|... . ||||..|.||||. |.|| pveildfLyLGsaehasnlqlLkelkitallnvsaelpnvfeelfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayL MKEFGWPLEKAYNYVKQKRSITRPNAGFMRQLSEYE ||| . ||.|...|||.||| || ||..|| |.| mkekkvrleeafefvkqrrsiisPnfgfvgqLlefe |
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| Phosphatase | SSH1.AA | DSPc | 316-446 | 33 | 5.4e-46 | 161.85 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 316-446 Range on HMM: 1-151/151 Sequence Identity: 33% (51 aa) LYLGSEWNAS-NLEELQGSGVDYILNVTREIDN---FFPGLFAYHNIR-VYD---------EETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSA |||||. .. ... || |.....|.|.|..| . .. | | .| | | ...|.. .. ..|. ||....... |.||||..|.|||| LYLGSYPHHMADPAFLQKHGITHVINCTMECPNNWFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRSA STVIAYAMKEFGWPLEKAYNYV-----KQKR-SITRPNAGFMRQLSEYEGI . .||| || ...... ||..| ||.| .. .||..|.||| ||| . CLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
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| Phosphatase | SSH1.AA | Subfamily.DSP19.PD | 312-444 | 44 | 1.6e-41 | 131.9 | In-house | 5-137 (139) | Show / Hide |
Range on Protein: 312-444 Range on HMM: 5-137/139 Sequence Identity: 44% (59 aa) IFDHLYLGSEWNASNLEELQGSGVDYILNVTREIDNFFPGLFAYHNIRVYDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIAYAMKE . ..||||| |...|.|. .. .||||. ...|.|| | | .| ..|.. |.||....|| ||..|.... ||||. ||||||||||| ||. vkprlylgsqdvaadkeilkklkitHilnvavgvpnvfpkdftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylmkd FGWPLEKAYNYVKQKRSITRPNAGFMRQLSEYE ||||...|...| .||.||..|| ||| eelslekalekvrearpcikPneGFikqLkeye |
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| Phosphatase | SSH1.AA | Family.DSP.PD | 271-468 | 32 | 1.4e-40 | 130.3 | In-house | 73-266 (387) | Show / Hide |
Range on Protein: 271-468 Range on HMM: 73-266/387 Sequence Identity: 32% (65 aa) VTSKEIRNELEKQMNCNLKELKEFIDNEMLlilgQMDKPSLIFDHLYLGSEWNASNLEELQGSGVDYILNVTREIDNFFP-GLFAYHNIRVYDEETTDLL |.|.. ||..... .|... . |.. . ||| |..|||||| .|.|||.|. || |.|.| . ..| . ..|..| . | ....| visgakqaelngfidvhtfdldtydhferv----engkpseilphlylgsllaaknlewlkelgvtkivnltddkpqftkelgikylripidDhnapple AHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIAYAMKEFGWPLEKAYNYVKQKRS-ITRPNAGFMRQLSEYEGILdaSKQRHNKLWRQQTDSSLQQ .. .|. ||......... |||||.|..||.. .||| || |. ||.|...|..||. ...|| ||..||...| . .|.. ... .. || | nlfekaidfieegndskgvVlVHCkaGkgRsgtliiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekek--lkvssevmelrfvissivq |
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| Phosphatase | SSH1.AA | Subfamily.DSP6.PD | 310-444 | 42 | 1.9e-40 | 128.3 | In-house | 3-139 (141) | Show / Hide |
Range on Protein: 310-444 Range on HMM: 3-139/141 Sequence Identity: 42% (58 aa) SLIFDHLYLGSEWNASNLEELQGSGVDYILNVTREIDNFFP--GLFAYHNIRVYDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIAY | ..|||||. .||||| |. ... |.|||| ...|.| | . |..| . |. ...| ... || .||..|....||.|||| ||||| . ..|| | veilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtlay AMKEFGWPLEKAYNYVKQKRSITRPNAGFMRQLSEYE |. |..||..||.|.| || || || ..| lmkklalslndaydlvkkkksnisPnfnfmgqlldfe |
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| Phosphatase | SSH1.AA | Subfamily.DSP10.PD | 310-444 | 44 | 3.3e-40 | 127.8 | In-house | 3-139 (141) | Show / Hide |
Range on Protein: 310-444 Range on HMM: 3-139/141 Sequence Identity: 44% (61 aa) SLIFDHLYLGSEWNASNLEELQGSGVDYILNVTREIDNFFP--GLFAYHNIRVYDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIAY | |. .|.||.| .|.. . |. |..|.|||| .. ||| ||. |..| | |.....| ...||..||..|... |. ||||. |.|||| |||| ssilpflllGnekdaadkdaldrlgikyvlnvttsvPnffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvviay AMKEFGWPLEKAYNYVKQKRSITRPNAGFMRQLSEYE || .. |..||..||.|| | || .|| || |.| vmkhlslslseaykfvkekrPiisPnlnfmGqllefe |
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| Phosphatase | SSH1.AA | Subfamily.DSP14.PD | 311-444 | 39 | 6.1e-37 | 117.3 | In-house | 4-136 (138) | Show / Hide |
Range on Protein: 311-444
Range on HMM: 4-136/138
Sequence Identity: 39% (53 aa)
LIFDHLYLGsEWNASNLEELQGSGVDYILNVTREIDNFFPGLFAYHNIRVYDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIAYAMK
| ..|||. |.. |.|. .. |.|||.|. . ... .|.| |.....| .|..|.. |...|... |.||||..||||||| |.|| ||
eitesLyls-gaaalkkeklkkkkitlivnvttelpetkledvktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlaylmk
EFGWPLEKAYNYVKQKRSITRPNAGFMRQLSEYE
|..||..||..|.| ||| || .|| .||
yeklsLreayklvksaRpiirPnvGFwkqlidyE
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| Phosphatase | SSH1.AA | Subfamily.DSP12.PD | 311-445 | 37 | 4e-35 | 111.5 | In-house | 4-140 (143) | Show / Hide |
Range on Protein: 311-445 Range on HMM: 4-140/143 Sequence Identity: 37% (50 aa) LIFDHLYLGSEWNASNLEELQGSGVDYILNVTREI-DNFFPG-LFAYHNIRVYDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIAYA | . ||||. .. . |.|. . .| |..| ... . .| ..||...||| | .|| .||... .. . ||||..|||||...|||| | eilpglylggleavqerellkelkithvlsvikeelpelqkekgvkskliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiviAYl MKEFGWPLEKAYNYVKQKRSITRPNAGFMRQLSEYEG |. ...||||.. ||.|.. ..||.||..|| .| mkkeklslekAlklvkekkkeiepNegFleQLklfek |
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| Phosphatase | SSH1.AA | Subfamily.DSP8.PD | 309-445 | 38 | 1.7e-33 | 106.1 | In-house | 2-140 (143) | Show / Hide |
Range on Protein: 309-445 Range on HMM: 2-140/143 Sequence Identity: 38% (53 aa) PSLIFDHLYLGSEWNASNLEELQGSGVDYILNVTREIDN--FFPGLFAYHNIRVYDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIA | | ..|||||. .. . | |. |..|.||.... . . .. | | |. . .|| ....|..||.||.....|.|||| | ||||. .|| ptrilpnlylGsqkdsldeellkklgisyvlnisescpkdvellkesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaia YAMKEFGWPLEKAYNYVKQKRSITRPNAGFMRQLSEYEG | ||.. |..||..||.||. || |. || ||| yimktlemsldeayrfvkekrptispnlnflgqLleyek |
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| Phosphatase | SSH1.AA | Subfamily.LRR-DSP.PD | 309-444 | 38 | 7.7e-30 | 94.0 | In-house | 2-135 (137) | Show / Hide |
Range on Protein: 309-444 Range on HMM: 2-135/137 Sequence Identity: 38% (53 aa) PSLIFDHLYLGSEWNASNLEELQGSGVDYILNVTrEIDNFFPGLFAYHNIRVYDEETTDLLAHWNEAYHFINKAkRNHSKCLVHCKMGVSRSASTVIAYA |.|| |.||||. | | |. .| .|| |. ... ..| || | | . | . .|. |..| ||.. |.. |.||. ||||||. |||| pdliidklylgcresamnksilkdnnvthilava-dfkplypdlfkyliidiedvdeadiyqhfkemnafideg-rekggvlihcragvsrsatlviayl MKEFGWPLEKAYNYVKQKRSITRPNAGFMRQLSEYE ||. ...|.. |..||. .|| ||. || .| mkknslkfkealdlvikkrpriypnrgfldqlkkfe |
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| Phosphatase | SSH1.AA | Subfamily.DSP3.PD | 312-444 | 32 | 3.5e-28 | 88.9 | In-house | 5-146 (148) | Show / Hide |
Range on Protein: 312-444 Range on HMM: 5-146/148 Sequence Identity: 32% (47 aa) IFDHLYLGSEWNASNLEELQGSGVDYILNVTRE--------IDNFFPG-LFAYHNIRVYDEETTDLLAHWNEAYHFINKAKRN-HSKCLVHCKMGVSRSA .....|.| | |.. |.|. |. ..|| ... ..|. . |. . | | ..|| ....|| .||..| .. ..| ||||..|.|||| vypkvyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisRsa STVIAYAMKEFGWPLEKAYNYVKQKRSITrPNAGFMRQLSEYE |.|| | |..| . |..||.|. || ||..|| |.. tlvlayLmirrkltlkeaiktvrkkreil-PneGflkqLleld |
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| Phosphatase | SSH1.AA | Subfamily.DSP15.PD | 312-444 | 33 | 6.2e-27 | 84.7 | In-house | 5-136 (138) | Show / Hide |
Range on Protein: 312-444 Range on HMM: 5-136/138 Sequence Identity: 33% (44 aa) IFDHLYLGSEWNASNLEELQGSGVDYILNVTREIDNFFPGlFAYHNIRVYDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIAYAMKE . ||.|. .|.. | |. . .|| . . . .... . | |.. | .|| ...|. .|| |.. . ...|||| |.||| .|.|| | vlpGlyvGnfrdakdkeqleenkithilsihdsakplled-ikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayimtv FGWPLEKAYNYVKQKRSITRPNAGFMRQLSEYE . |.| . ||. ||.. ||.|| ||| |.| telswedalkavkaarsvanPnvGfrrqlqefe |
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| Phosphatase | SSH1.AA | Subfamily.STYX.PD | 315-446 | 34 | 2.2e-23 | 73.3 | In-house | 8-146 (146) | Show / Hide |
Range on Protein: 315-446 Range on HMM: 8-146/146 Sequence Identity: 34% (47 aa) HLYLGSE--WNASNLEELQGSGVDYILNVTREID-----NFFPGLFAYHNIRVYDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIAY |.|| |.|| |. |. .|. . ..|. || | | . | |. . ... . .. .||... .. | ||| . |.||||. |||| glflgpysaamksklevlkehgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviay AMKEFGWPLEKAYNYVKQKRSITRPNAGFMRQLSEYEGI |. .| .|..||...| ||.||..|| ||| | imetyglkyreafayvqerrfcinpnegfvsqlkeyeai |
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| Phosphatase | SSH1.AA | Subfamily.STYXL1.PD | 314-444 | 35 | 6.4e-23 | 72.1 | In-house | 8-141 (143) | Show / Hide |
Range on Protein: 314-444 Range on HMM: 8-141/143 Sequence Identity: 35% (48 aa) DHLYLGSEWNASNLEELQGSGVDYILNVTREIDNFFPGLFA---YHNIRVYDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIAYAMK ..|||| . .| | . . | .||. . .... || .|.| ||. .||| . .|. .||.| |.. . || . |.||||. .||| | gklylGnykqaqnpaikkdlkvkahvnvssdaekliagladvakllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaaviiaylmy EFGWPLEKAYNYVKQKRSITRPNAGFMRQLSEYE . . |.|||.|.|. .. .|| .|. ||||.| skkitlkkaykylkkckenvkPnrafveqlseWe |
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| Phosphatase | SSH1.AA | Subfamily.PTPMT1.PD | 360-443 | 33 | 2e-14 | 44.2 | In-house | 60-143 (146) | Show / Hide |
Range on Protein: 360-443 Range on HMM: 60-143/146 Sequence Identity: 33% (28 aa) VYDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIAYAMKEFGWPLEKAYNYVKQKRSITRPNAGFMRQLSEY . | . |.. .|. .||.| . . |. |||| | .|||. |..| ||. . |.| ...|.||.. | . .| |.|. tvDfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlkskqwralqef |
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| Phosphatase | SSH1.AA | Subfamily.Laforin.PD | 383-429 | 31 | 1.8e-06 | 18.3 | In-house | 101-147 (165) | Show / Hide |
Range on Protein: 383-429 Range on HMM: 101-147/165 Sequence Identity: 31% (14 aa) KRNHSKCLVHCKMGVSRSASTVIAYAMKEFGWPLEKAYNYVKQKRSI . . |||. || ||.. | . . .|| | | .. || . lekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpv |
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| Phosphatase | SSH1.AA | Subfamily.R_Nematode_3.PD | 374-405 | 35 | 9.5e-06 | 15.6 | In-house | 186-217 (267) | Show / Hide |
Range on Protein: 374-405 Range on HMM: 186-217/267 Sequence Identity: 35% (11 aa) EAYHFINKAKRNHSKCLVHCKMGVSRSASTVI || . |.... . . .|||. |.||||. . ealelikfveksktpvvVHCsdGisRsatlaa |
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