• Phosphatome.Net

Gene SSH3

SSH3
Species: Human
Alias: FLJ20515, SSH3L, FLJ42240, SSH3, FLJ10928
External Links: COSMIC , Entrez Gene
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: DSP
Subfamily: Slingshot
Protein domain

Protein domains of SSH3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DEK_C SSH3.AA DEK_C 271-324 32 3.2e-18 63.87 Pfam 1-56 (56) Show / Hide 
Range on Protein: 271-324
Range on HMM: 1-56/56
Sequence Identity: 32% (18 aa)

MEQAIRAELWKVLDVSDLESVTSKEIRQALELRL-GLPLQ-QYRDFIDNQMLLLVA
 ...|..|....|  .||..||.|.||..|| |. |  |. ....||..|.. . .
TDEQIKEEIREILRTADLMTVTMKQIRKQLEQRFPGCDLSKHRKAFIKEQIEEFLD
Phosphatase SSH3.AA Family.DSP.PD 327-468 37 2.2e-38 123.1 In-house 105-248 (387) Show / Hide 
Range on Protein: 327-468
Range on HMM: 105-248/387
Sequence Identity: 37% (52 aa)

DRASRIFPHLYLGSEWNAANLEELQRNRVTHILNMAREIDNFYP-ERFTYHNVRLWDEESAQLLPHWKETHRFIEAARAQGTHVLVHCKMGVSRSAATVL
|.|.|||||||  .| |||.|....||.|.|.. . ..|.  . ..|... . | .. .|  .. .  .||| .. ..  ||||||.|..||.. || ||
gkpseilphlylgsllaaknlewlkelgvtkivnltddkpqftkelgikylripidDhnapplenlfekaidfieegndskgvVlVHCkaGkgRsgtlii

AYAMKQYECSLEQALRHVQELRP-IARPNPGFLRQLQIYQGILT
.. ..||.||..|.. || ...|| |||.||. ..  .      
aYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekekl
Phosphatase SSH3.AA Subfamily.Slingshot.PD 329-466 65 6.9e-73 233.6 In-house 2-139 (139) Show / Hide 
Range on Protein: 329-466
Range on HMM: 2-139/139
Sequence Identity: 65% (90 aa)

ASRIFPHLYLGSEWNAANLEELQRNRVTHILNMAREIDNFYPERFTYHNVRLWDEESAQLLPHWKETHRFIEAARAQGTHVLVHCKMGVSRSAATVLAYA
||.|| ||||||||||.|||||..|.|..|||...|||||.||.|.|.|.|..|||...||.||.||..|||.|...|..|||||||||||||.||.|||
askifdhlylGsewnasnleelkengveyilnvtkeidnffpekfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviaya

MKQYECSLEQALRHVQELRPIARPNPGFLRQLQIYQGI
||.||.|||.||..|.| | |..|| |||.||..|.||
mkeyelsleealeyvkerrsiikpnkgflkqlkvyegi
Phosphatase SSH3.AA Subfamily.DSP19.PD 330-464 47 3.8e-45 143.7 In-house 3-137 (139) Show / Hide 
Range on Protein: 330-464
Range on HMM: 3-137/139
Sequence Identity: 47% (64 aa)

SRIFPHLYLGSEWNAANLEELQRNRVTHILNMAREIDNFYPERFTYHNVRLWDEESAQLLPHWKETHRFIEAARAQGTHVLVHCKMGVSRSAATVLAYAM
... |.|||||   ||..|.|.....|||||.| ...|..|. ||| .. ..|.. ..|| ..||.. ||| || ..  |||||. ||||||. |.|| |
aevkprlylgsqdvaadkeilkklkitHilnvavgvpnvfpkdftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylm

KQYECSLEQALRHVQELRPIARPNPGFLRQLQIYQ
|. | |||.||..|.| || ..|| ||..||. |.
kdeelslekalekvrearpcikPneGFikqLkeye
Phosphatase SSH3.AA Subfamily.DSP1.PD 330-464 38 1.4e-42 135.7 In-house 3-137 (139) Show / Hide 
Range on Protein: 330-464
Range on HMM: 3-137/139
Sequence Identity: 38% (52 aa)

SRIFPHLYLGSEWNAANLEELQRNRVTHILNMAREIDNFYPERFTYHNVRLWDEESAQLLPHWKETHRFIEAARAQGTHVLVHCKMGVSRSAATVLAYAM
..| ..|||||. .|.||. |.. ..|..||...|..| ..| |.|... . |...|... ...|   ||......| .|||||..|.||||. |||| |
veildfLyLGsaehasnlqlLkelkitallnvsaelpnvfeelfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayLm

KQYECSLEQALRHVQELRPIARPNPGFLRQLQIYQ
|. ...||.|  .|.. | |  || ||..||  ..
kekkvrleeafefvkqrrsiisPnfgfvgqLlefe
Phosphatase SSH3.AA DSPc 328-466 27 1.6e-40 141.82 SMART 1-172 (172) Show / Hide 
Range on Protein: 328-466
Range on HMM: 1-172/172
Sequence Identity: 27% (48 aa)

RASRIFPHLYLGSEWNAA--NLEELQRNRVTHILNMAREIDN-----------------FYPERFTYHNVR-LWD-------EESAQLLPHWKETHRFIE
  |.| |||||||.  .   |...|. . .||..|...|...                   .  |.| ..  . |       .......... |. .||.
GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH

AARAQGTHVLVHCKMGVSRSAATVLAYAMKQYECSLEQALRHV-----QELR-PIARPNPGFLRQLQIYQGI
..|..|  |||||..|.||||. . || || . .|.. |...|     .. | || .|| .|..||. .. .
DCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK
Phosphatase SSH3.AA Subfamily.DSP12.PD 330-465 38 2.3e-38 122.1 In-house 3-140 (143) Show / Hide 
Range on Protein: 330-465
Range on HMM: 3-140/143
Sequence Identity: 38% (53 aa)

SRIFPHLYLGSEWNAANLEELQRNRVTHILNMAREI-DNFYPER-FTYHNVRLWDEESAQLLPHWKETHRFIEAARAQGTHVLVHCKMGVSRSAATVLAY
|.| | ||||.  .... |.|.   .||.| ...|  ...  |.  .. .. . ||... || | .|. |||| ..... .|||||..|||||...|.||
seilpglylggleavqerellkelkithvlsvikeelpelqkekgvkskliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiviAY

AMKQYECSLEQALRHVQELRPIARPNPGFLRQLQIYQG
 ||....|||.||. |.| .. ..|| |||.||.... 
lmkkeklslekAlklvkekkkeiepNegFleQLklfek
Phosphatase SSH3.AA Subfamily.DSP14.PD 330-463 38 3.1e-37 118.3 In-house 3-135 (138) Show / Hide 
Range on Protein: 330-463
Range on HMM: 3-135/138
Sequence Identity: 38% (52 aa)

SRIFPHLYLGsEWNAANLEELQRNRVTHILNMAREIDNFYPERFTYHNVRLWDEESAQLLPHWKETHRFIEAARAQGTHVLVHCKMGVSRSAATVLAYAM
|.| ..|||.    | . |.|.....|.|.|...|. . . | . . .... |...|.| .|..|.   ||.....| ..||||..||||||. |||| |
seitesLyls-gaaalkkeklkkkkitlivnvttelpetkledvktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlaylm

KQYECSLEQALRHVQELRPIARPNPGFLRQLQIY
|  . ||..| ..|.. ||| |||.|| .||. |
kyeklsLreayklvksaRpiirPnvGFwkqlidy
Phosphatase SSH3.AA DSPc 336-466 29 1.2e-35 125.86 Pfam 1-151 (151) Show / Hide 
Range on Protein: 336-466
Range on HMM: 1-151/151
Sequence Identity: 29% (45 aa)

LYLGSEWNAA-NLEELQRNRVTHILNMAREIDN---FYPERFTYHNVR-LWD---------EESAQLLPHWKETHRFIEAARAQGTHVLVHCKMGVSRSA
|||||.  .  ... || . .||..| ..|..|   . ...|.| ..  . |         ...... ..  .   ||...|..|  |||||..|.||||
LYLGSYPHHMADPAFLQKHGITHVINCTMECPNNWFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRSA

ATVLAYAMKQYECSLEQALRHV-----QELR-PIARPNPGFLRQLQIYQGI
. ..|| || . .|.. |...|     .. | |. .||..|.|||. |. .
CLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ
Phosphatase SSH3.AA Subfamily.DSP10.PD 329-461 41 1.2e-34 109.8 In-house 2-136 (141) Show / Hide 
Range on Protein: 329-461
Range on HMM: 2-136/141
Sequence Identity: 41% (55 aa)

ASRIFPHLYLGSEWNAANLEELQRNRVTHILNMAREIDNFYPER--FTYHNVRLWDEESAQLLPHWKETHRFIEAARAQGTHVLVHCKMGVSRSAATVLA
||.|.|.|.||.| .||. . |.|  ....||.. .. ||. |.  ..|... . |..  .|  ...|.  ||| || .|..|||||. |.||||. |.|
assilpflllGnekdaadkdaldrlgikyvlnvttsvPnffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvvia

YAMKQYECSLEQALRHVQELRPIARPNPGFLRQLQ
| ||  . ||..| . |.| |||  || .|. || 
yvmkhlslslseaykfvkekrPiisPnlnfmGqll
Phosphatase SSH3.AA Subfamily.DSP6.PD 331-463 36 2.9e-33 105.1 In-house 4-138 (141) Show / Hide 
Range on Protein: 331-463
Range on HMM: 4-138/141
Sequence Identity: 36% (49 aa)

RIFPHLYLGSEWNAANLEELQRNRVTHILNMAREIDNFYPE--RFTYHNVRLWDEESAQLLPHWKETHRFIEAARAQGTHVLVHCKMGVSRSAATVLAYA
.| |.|||||. .|.||| |.. .. ..||.. ...|.. |   ..|... . |. |..|  .. |. .||. || . ..|||||  |||||. .||| |
eilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtlayl

MKQYECSLEQALRHVQELRPIARPNPGFLRQLQIY
|....||..|   |.. ..   ||  |. ||  . 
mkklalslndaydlvkkkksnisPnfnfmgqlldf
Phosphatase SSH3.AA Subfamily.LRR-DSP.PD 330-463 41 3e-32 101.9 In-house 3-134 (137) Show / Hide 
Range on Protein: 330-463
Range on HMM: 3-134/137
Sequence Identity: 41% (55 aa)

SRIFPHLYLGSEWNAANLEELQRNRVTHILNMArEIDNFYPERFTYHNVRLWDEESAQLLPHWKETHRFIEAARAQGThVLVHCKMGVSRSAATVLAYAM
. | ..||||.   | |   |. | ||||| .| ... .||. | |  . . | . |..  |.||.  ||.  | .|  ||.||. ||||||. |.|| |
dliidklylgcresamnksilkdnnvthilava-dfkplypdlfkyliidiedvdeadiyqhfkemnafidegrekgg-vlihcragvsrsatlviaylm

KQYECSLEQALRHVQELRPIARPNPGFLRQLQIY
|. .  ...||  |.. ||  .||.||| ||. .
kknslkfkealdlvikkrpriypnrgfldqlkkf
Phosphatase SSH3.AA Subfamily.DSP15.PD 330-464 37 6.3e-32 101.0 In-house 3-136 (138) Show / Hide 
Range on Protein: 330-464
Range on HMM: 3-136/138
Sequence Identity: 37% (50 aa)

SRIFPHLYLGSEWNAANLEELQRNRVTHILNMAREIDNFYPErFTYHNVRLWDEESAQLLPHWKETHRFIEAARAQGTHVLVHCKMGVSRSAATVLAYAM
... | ||.|.  .| . | |..|..|||| .  . . .... ..|  ..  |  . .|  ..||.  || ..| .|. |||||  |.|||. | || | 
nkvlpGlyvGnfrdakdkeqleenkithilsihdsakplled-ikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayim

KQYECSLEQALRHVQELRPIARPNPGFLRQLQIYQ
  | | |.||. |.  |..| || || |||| .. 
tvtelswedalkavkaarsvanPnvGfrrqlqefe
Phosphatase SSH3.AA Subfamily.DSP3.PD 331-461 35 6.9e-30 94.5 In-house 4-143 (148) Show / Hide 
Range on Protein: 331-461
Range on HMM: 4-143/148
Sequence Identity: 35% (50 aa)

RIFPHLYLGSEWNAANLEELQRNRVTHILNMARE--------IDNFYPE-RFTYHNVRLWDEESAQLLPHWKETHRFIEAARAQ-GTHVLVHCKMGVSRS
..|..|.| |  | . |.|..  .||.|| |..         ..|| .   .|. |   |  ...|  ...|   ||. | .| ...|||||..|.||||
evypkvyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisRs

AATVLAYAMKQYECSLEQALRHVQELRPIaRPNPGFLRQLQ
. |||| | . . .|..|...|.. | |  || |||.||  
atlvlayLmirrkltlkeaiktvrkkrei-lPneGflkqLl
Phosphatase SSH3.AA Subfamily.DSP8.PD 330-464 36 7.5e-29 91.1 In-house 3-139 (143) Show / Hide 
Range on Protein: 330-464
Range on HMM: 3-139/143
Sequence Identity: 36% (50 aa)

SRIFPHLYLGSEWNAANLEELQRNRVTHILNMAREIDN--FYPERFTYHNVRLWDEESAQLLPHWKETHRFIEAARAQGTHVLVHCKMGVSRSAATVLAY
|| |.|||||. .. . | |... ....||.... .      .   .. . . |. . .|||.....  ||. ||.. ..|||||  | ||||. ..|| 
trilpnlylGsqkdsldeellkklgisyvlnisescpkdvellkesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaiay

AMKQYECSLEQALRHVQELRPIARPNPGFLRQLQIYQ
||. | ||..| |.|.| ||   ||  || ||  |. 
imktlemsldeayrfvkekrptispnlnflgqLleye
Phosphatase SSH3.AA Subfamily.STYX.PD 331-465 34 3.8e-23 72.5 In-house 4-145 (146) Show / Hide 
Range on Protein: 331-465
Range on HMM: 4-145/146
Sequence Identity: 34% (48 aa)

RIFPHLYLGSEWNA--ANLEELQRNRVTHILNMAREID-----NFYPERFTYHNVRLWDEESAQLLPHWKETHRFIEAARAQGTHVLVHCKMGVSRSAAT
|.| |.||    |  ..|| |... .|||. . ..|.       .|.|| |  . . |.   ... .  ... ||. .  .| .|||| .|.||||| |.
eilpglflgpysaamksklevlkehgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaal

VLAYAMKQYECSLEQALRHVQELRPIARPNPGFLRQLQIYQG
|| |. |     .| ..||| |    || || .||. |.   
viayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
Phosphatase SSH3.AA Subfamily.STYXL1.PD 332-461 29 1.2e-21 67.9 In-house 5-138 (143) Show / Hide 
Range on Protein: 332-461
Range on HMM: 5-138/143
Sequence Identity: 29% (39 aa)

IFPH-LYLGSEWNAANLEELQRNRVTHILNMAREIDNFYPERFT---YHNVRLWDEESAQLLPHWKETHRFIEAARAQGTHVLVHCKMGVSRSAATVLAY
..|. |||| . .| | .  .  .|   .|.. . ....          .... ||. |.||.. ||  .|||  . .|  |||  . |.||||| ..||
vlPgklylGnykqaqnpaikkdlkvkahvnvssdaekliagladvakllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaaviiay

AMKQYECSLEQALRHVQELRPIARPNPGFLRQLQ
 | ... .|..|. .... ..  .|| .|. ||.
lmyskkitlkkaykylkkckenvkPnrafveqls
Phosphatase SSH3.AA Subfamily.PTPMT1.PD 375-463 33 1.3e-15 48.0 In-house 55-143 (146) Show / Hide 
Range on Protein: 375-463
Range on HMM: 55-143/146
Sequence Identity: 33% (30 aa)

YHNVRLWDEESAQLLPHWKETHRFIEAARAQGTHVLVHCKMGVSRSAATVLAYAMKQYECSLEQALRHVQELRPIARPNPGFLRQLQIY
. ..  .|   |  | . .|. .|||  . .|  | |||| | .|||. | .| ||....| |.| ..... ||. | .   .| || .
qlqlatvDfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlkskqwralqef
Phosphatase SSH3.AA Subfamily.R_Nematode_3.PD 370-445 25 1e-08 25.4 In-house 164-243 (267) Show / Hide 
Range on Protein: 370-445
Range on HMM: 164-243/267
Sequence Identity: 25% (21 aa)

PERFTYHNVRLWDEESAQLLPhwKETHRFIEAARAQGTHVLVHCKMGVSRSAATVL---AYAM--KQY-ECSLEQALRHVQE
.  .| . .. | |..|.  |  ||    |.....  | |.|||. |.||||. .    .| .  |.  . .| . . ....
eftvthllykgWkelnapeep--kealelikfveksktpvvVHCsdGisRsatlaaielgyqliikskgkldllslikelrk
Phosphatase SSH3.AA Subfamily.CDC14.PD 348-448 21 2.6e-08 24.4 In-house 141-240 (258) Show / Hide 
Range on Protein: 348-448
Range on HMM: 141-240/258
Sequence Identity: 21% (22 aa)

EELQRNRVTHILNMAREIdnFYPERFTYHNVRLWDEESA-QLLPHWKETHRFIEAARAQGTHVLVHCKMGVSRSAATVLAYAMKQYECSLEQALRHVQEL
|  ..| ||.|. . ...  .  ..|| . .   |   .    |. .  ..|.|..      . |||| |. | .. . .| .|.|. . .... ...  
eyfrknnvttivrLnkkl--YdakkftdaGfahlDlffiDGtvPsdailkkfleitekaeGaiavhCkaGLGrtgtligcylikhyrftaaetiawlria

RP
||
rP
Phosphatase SSH3.AA Subfamily.DSP23.PD 394-448 25 1.6e-06 18.8 In-house 54-108 (128) Show / Hide 
Range on Protein: 394-448
Range on HMM: 54-108/128
Sequence Identity: 25% (14 aa)

ETHRFIEAARAQGTHVLVHCKMGVSRSAATVLAYAMKQYECSLEQALRHVQELRP
.  | .| | ...  | ||| .|. |. . .  | .|. . . ..|.  |...|.
rlvriveeaekkeeavgvhcalGlGrtGtllacylvkeeglaaddaiaevrkrrk
Phosphatase SSH3.AA Subfamily.RNGTT.PD 393-449 24 7.5e-06 16.3 In-house 61-122 (140) Show / Hide 
Range on Protein: 393-449
Range on HMM: 61-122/140
Sequence Identity: 24% (15 aa)

KETHRFIEAAR-----AQGTHVLVHCKMGVSRSAATVLAYAMKQYECSLEQALRHVQELRPI
..|. ||.  .       .. . |||  |  |    ..|| ... ..|.|.|.    . || 
eqtklfiklvkeflkkkPdevigvhCthGfnrtGflivayLvekedwsveaavalfakarpp
Phosphatase SSH3.AA Subfamily.Laforin.PD 400-449 32 9.2e-06 16.0 In-house 98-147 (165) Show / Hide 
Range on Protein: 400-449
Range on HMM: 98-147/165
Sequence Identity: 32% (16 aa)

EAARAQGTHVLVHCKMGVSRSAATVLAYAMKQYECSLEQALRHVQELRPI
|   .|  | |||. || ||.| |  . .   . || .   ..   ||. 
hallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpv
Sequence
Name Sequence Type Origin Length Description Download
SSH3.AA Protein None 659 None Fasta, JSON
SSH3.NA RNA None 1977 None Fasta, JSON
SSH3.AA.PD_328-466 Protein Phosphatase Domain None 139 None Fasta, JSON