Gene SSH2
SSH2
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of SSH2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| DEK_C | SSH2.AA | DEK_C | 250-303 | 35 | 1.5e-18 | 64.92 | Pfam | 1-56 (56) | Show / Hide |
Range on Protein: 250-303 Range on HMM: 1-56/56 Sequence Identity: 35% (20 aa) TERLIKTKLREIMMQKDLENITSKEIRTELEMQM-VCNLR-EFKEFIDNEMIVILG |.. ||...|||... ||...|.|.|| .|| .. |.| ..|.||.... ..|. TDEQIKEEIREILRTADLMTVTMKQIRKQLEQRFPGCDLSKHRKAFIKEQIEEFLD |
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| Phosphatase | SSH2.AA | Family.DSP.PD | 305-451 | 34 | 1e-38 | 124.0 | In-house | 104-252 (387) | Show / Hide |
Range on Protein: 305-451 Range on HMM: 104-252/387 Sequence Identity: 34% (50 aa) MDSPTQIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFP-GVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTV |..|..|..||| .|.||| |.. || |.|.| . ..| . ..|..| . | .|..| .. ..||......... |||||.|..||.. .||| ngkpseilphlylgsllaaknlewlkelgvtkivnltddkpqftkelgikylripidDhnapplenlfekaidfieegndskgvVlVHCkaGkgRsgtli IAYAMKEYGWNLDRAYDYVKERRT-VTKPNPSFMRQLEEYQGILLASKQ || .|..|. |.|.|...| |..|| |..||.... .| .. iaYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekeklkvss |
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| Phosphatase | SSH2.AA | Subfamily.Slingshot.PD | 308-445 | 70 | 7.1e-78 | 249.5 | In-house | 2-139 (139) | Show / Hide |
Range on Protein: 308-445 Range on HMM: 2-139/139 Sequence Identity: 70% (97 aa) PTQIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYA ...||.|..|||||||||||.|...||.||||||.|||||||. |.|.||||||||.||||..||.|||||.|||..|||.||||||||||||||||||| askifdhlylGsewnasnleelkengveyilnvtkeidnffpekfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviaya MKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGI ||||...|..|..||||||...||| .|..||..|.|| mkeyelsleealeyvkerrsiikpnkgflkqlkvyegi |
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| Phosphatase | SSH2.AA | Subfamily.DSP1.PD | 308-443 | 39 | 3.7e-44 | 140.5 | In-house | 2-137 (139) | Show / Hide |
Range on Protein: 308-443 Range on HMM: 2-137/139 Sequence Identity: 39% (54 aa) PTQIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYA |..| ....|||. .||||. |.. .. .|||..|..| |. .|.|..| | |.. .|....... .|| ..||.| . ||||..|.||||. |.|| pveildfLyLGsaehasnlqlLkelkitallnvsaelpnvfeelfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayL MKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQ ||| ..|. |...||.||.. .|| .|..|| |.. mkekkvrleeafefvkqrrsiisPnfgfvgqLlefe |
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| Phosphatase | SSH2.AA | DSPc | 307-445 | 28 | 1e-43 | 152.49 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 307-445 Range on HMM: 1-172/172 Sequence Identity: 28% (49 aa) SPTQIFEHVFLGSEWNAS--NLEDLQNRGVRYILNVTREIDN-----------------FFPGVFEYHNIR-VYD-------EEATDLLAYWNDTYKFIS .|..| .|..|||. .. |.. |.. .. ...|||.|... ... |.| .| . | .. |....|.. .|.||. GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH KAKKHGSKCLVHCKMGVSRSASTVIAYAMKEYGWNLDRAYDYV-----KERR-TVTKPNPSFMRQLEEYQGI .... | |.||||..|.||||. .||| || ...... ||..| |.|| || .|..|| |.. . DCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
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| Phosphatase | SSH2.AA | DSPc | 315-445 | 33 | 3.2e-41 | 145.24 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 315-445 Range on HMM: 1-151/151 Sequence Identity: 33% (50 aa) VFLGSEWNAS-NLEDLQNRGVRYILNVTREIDN---FFPGVFEYHNIR-VYD---------EEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSA ..|||. .. ... ||. |. ...|.|.|..| . .. |.| .| | | .. |.. .| . ..||..... | |.||||..|.|||| LYLGSYPHHMADPAFLQKHGITHVINCTMECPNNWFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRSA STVIAYAMKEYGWNLDRAYDYV-----KERR-TVTKPNPSFMRQLEEYQGI . .||| || ...... |||.| |.|| . ||..|.||| ||. . CLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
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| Phosphatase | SSH2.AA | Subfamily.DSP6.PD | 308-442 | 38 | 2.6e-39 | 124.5 | In-house | 2-138 (141) | Show / Hide |
Range on Protein: 308-442 Range on HMM: 2-138/141 Sequence Identity: 38% (53 aa) PTQIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFP--GVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIA | .| ....|||. .||||| |.. ...|.|||| ...|.| | ..|..| . |. ..| ... .. .|| .|... ||.|||| ||||| . ..| pveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtla YAMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEY | ||.. |. |||.||.... || .|| || .. ylmkklalslndaydlvkkkksnisPnfnfmgqlldf |
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| Phosphatase | SSH2.AA | Subfamily.DSP19.PD | 310-443 | 40 | 2.9e-39 | 124.5 | In-house | 4-137 (139) | Show / Hide |
Range on Protein: 310-443 Range on HMM: 4-137/139 Sequence Identity: 40% (54 aa) QIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYAMK .. ....||| |...| |..... .||||. ...|.|| |.| .| ..|.. |.||.|.... .|| .|.... ||||. ||||||| |||| || evkprlylgsqdvaadkeilkklkitHilnvavgvpnvfpkdftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylmk EYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQ . .| .|...|.| | ||| |..||.||. deelslekalekvrearpcikPneGFikqLkeye |
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| Phosphatase | SSH2.AA | Subfamily.DSP10.PD | 308-443 | 40 | 3.4e-37 | 117.9 | In-house | 2-139 (141) | Show / Hide |
Range on Protein: 308-443 Range on HMM: 2-139/141 Sequence Identity: 40% (56 aa) PTQIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFP--GVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIA ..|. ...||.| .|.. . |. |..|.|||| .. ||| |...|..| | |.. ..| .......|| .|.|.||. ||||. |.|||| |||| assilpflllGnekdaadkdaldrlgikyvlnvttsvPnffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvvia YAMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQ || . | || .|||.| . || .|| || |.. yvmkhlslslseaykfvkekrPiisPnlnfmGqllefe |
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| Phosphatase | SSH2.AA | Subfamily.DSP8.PD | 308-443 | 36 | 2.8e-34 | 108.5 | In-house | 2-139 (143) | Show / Hide |
Range on Protein: 308-443 Range on HMM: 2-139/143 Sequence Identity: 36% (51 aa) PTQIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREIDN--FFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIA ||.| ....|||. .. . | |.. |. |.||.... . . ... | | |. .|| ... ...|| ||... .|.|||| | ||||. .|| ptrilpnlylGsqkdsldeellkklgisyvlnisescpkdvellkesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaia YAMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQ | ||. .|| || .|||.|. .|| |. || ||. yimktlemsldeayrfvkekrptispnlnflgqLleye |
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| Phosphatase | SSH2.AA | Subfamily.DSP14.PD | 309-443 | 35 | 2.9e-34 | 108.5 | In-house | 3-136 (138) | Show / Hide |
Range on Protein: 309-443 Range on HMM: 3-136/138 Sequence Identity: 35% (48 aa) TQIFEHVFLGsEWNASNLEDLQNRGVRYILNVTREIDNFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYAM ..| |...|. |.. | |..... |.|||.|. . ... .|.| |.....| .... ... | ..||.| |.||||..||||||| |.|| | seitesLyls-gaaalkkeklkkkkitlivnvttelpetkledvktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlaylm KEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQ | .| || .||..| . .||. | .|| .| kyeklsLreayklvksaRpiirPnvGFwkqlidyE |
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| Phosphatase | SSH2.AA | Subfamily.DSP12.PD | 310-443 | 30 | 3.8e-33 | 105.0 | In-house | 4-139 (143) | Show / Hide |
Range on Protein: 310-443 Range on HMM: 4-139/143 Sequence Identity: 30% (41 aa) QIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREI-DNFFPG-VFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYA .| . ..||. .. . | |.. . .| |..| ... .. .| ..||. .||| . ... .||... ... . ||||..|||||...|||| eilpglylggleavqerellkelkithvlsvikeelpelqkekgvkskliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiviAYl MKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQ ||.....|..|.. ||| . ..|| .|..|| .. mkkeklslekAlklvkekkkeiepNegFleQLklfe |
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| Phosphatase | SSH2.AA | Subfamily.LRR-DSP.PD | 308-443 | 32 | 2.1e-28 | 89.3 | In-house | 2-135 (137) | Show / Hide |
Range on Protein: 308-443 Range on HMM: 2-135/137 Sequence Identity: 32% (44 aa) PTQIFEHVFLGSEWNASNLEDLQNRGVRYILNVTrEIDNFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSkCLVHCKMGVSRSASTVIAYA | .| ....||. | | |.. .| .|| |. ... ..| .| | | . | . .|. ..... || . ...| |.||. ||||||. |||| pdliidklylgcresamnksilkdnnvthilava-dfkplypdlfkyliidiedvdeadiyqhfkemnafidegrekgg-vlihcragvsrsatlviayl MKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQ ||. .. .|.| |...|. .||. |. || .. mkknslkfkealdlvikkrpriypnrgfldqlkkfe |
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| Phosphatase | SSH2.AA | Subfamily.DSP3.PD | 310-442 | 30 | 1.4e-25 | 80.3 | In-house | 4-145 (148) | Show / Hide |
Range on Protein: 310-442 Range on HMM: 4-145/148 Sequence Identity: 30% (43 aa) QIFEHVFLGSEWNASNLEDLQNRGVRYILNVTRE--------IDNFFPG-VFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKH-GSKCLVHCKMGVSRS .....|..| | |.. | |.. |. ..|| ... ..|. . .|. . | | ..|| .|.. .|| .| .. ..| ||||..|.||| evypkvyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisRs ASTVIAYAMKEYGWNLDRAYDYVKERRTVTkPNPSFMRQLEEY | |.|| | .| | |...|... || |..|| |. atlvlayLmirrkltlkeaiktvrkkreil-PneGflkqLlel |
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| Phosphatase | SSH2.AA | Subfamily.DSP15.PD | 310-443 | 29 | 1.5e-25 | 80.1 | In-house | 4-136 (138) | Show / Hide |
Range on Protein: 310-443 Range on HMM: 4-136/138 Sequence Identity: 29% (39 aa) QIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFPGvFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYAMK .. . ...|. .|.. | |.. . .|| . . . .... ..| |.. | .|| ..... .|| |.. .|...|||| |.|||. |.|| | kvlpGlyvGnfrdakdkeqleenkithilsihdsakplled-ikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayimt EYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQ .. . | || |.|..|| | |||.|.. vtelswedalkavkaarsvanPnvGfrrqlqefe |
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| Phosphatase | SSH2.AA | Subfamily.STYX.PD | 311-444 | 35 | 5.9e-24 | 75.0 | In-house | 5-145 (146) | Show / Hide |
Range on Protein: 311-444 Range on HMM: 5-145/146 Sequence Identity: 35% (50 aa) IFEHVFLGSE--WNASNLEDLQNRGVRYILNVTREID-----NFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTV |. .||| |.|| |...|. .|. . ..|. || | | . | |. ... | . .|| .. ..| | ||| . |.||||. | ilpglflgpysaamksklevlkehgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalv IAYAMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQG ||| |. || . |. ||.||| . .|| |..||.||. iayimetyglkyreafayvqerrfcinpnegfvsqlkeyea |
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| Phosphatase | SSH2.AA | Subfamily.STYXL1.PD | 313-442 | 33 | 1.3e-22 | 70.9 | In-house | 8-140 (143) | Show / Hide |
Range on Protein: 313-442 Range on HMM: 8-140/143 Sequence Identity: 33% (44 aa) EHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFPGVFE---YHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYAMK ....|| . .| | . .. |. .||. . .... |. . .|.| ||. .||| .. .|| | ||.|. || . |.||||. .||| | gklylGnykqaqnpaikkdlkvkahvnvssdaekliagladvakllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaaviiaylmy EYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEY .. ..| .||.|.|. . ||| .|. ||.|. skkitlkkaykylkkckenvkPnrafveqlseW |
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| Phosphatase | SSH2.AA | Subfamily.PTPMT1.PD | 353-443 | 28 | 4.2e-15 | 46.2 | In-house | 54-144 (146) | Show / Hide |
Range on Protein: 353-443 Range on HMM: 54-144/146 Sequence Identity: 28% (26 aa) EYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYAMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQ |. .. . | . |.. ... .||.| ...||. |||| | .|||. |..| ||.. .. . | ...|..| . . . .| |.|.. eqlqlatvDfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlkskqwralqefk |
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| Phosphatase | SSH2.AA | Subfamily.DSP23.PD | 329-427 | 24 | 9.7e-07 | 19.3 | In-house | 9-108 (128) | Show / Hide |
Range on Protein: 329-427 Range on HMM: 9-108/128 Sequence Identity: 24% (24 aa) LQNRGVRYILNVTREIDNFFPGV--FEYHNIRVYDEEATdLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYAMKEYGWNLDRAYDYVKERR | ..|.|.....| | .. . .. |.. | | . .. . .|.|.. ||| .|. |. . . | .|| | || |..|| ladqGirvlvslttegapyseaapsltlrridipdfcPP-aleqvarlvriveeaekkeeavgvhcalGlGrtGtllacylvkeeglaaddaiaevrkrr T k |
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| Phosphatase | SSH2.AA | Subfamily.CDC14.PD | 376-423 | 25 | 1.2e-06 | 18.8 | In-house | 189-236 (258) | Show / Hide |
Range on Protein: 376-423 Range on HMM: 189-236/258 Sequence Identity: 25% (12 aa) KFISKAKKHGSKCLVHCKMGVSRSASTVIAYAMKEYGWNLDRAYDYVK ||.. . | . |||| |. | .. . .| .|.|. . . . ... kfleitekaeGaiavhCkaGLGrtgtligcylikhyrftaaetiawlr |
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| Phosphatase | SSH2.AA | Subfamily.Laforin.PD | 383-428 | 30 | 4.9e-06 | 16.7 | In-house | 102-147 (165) | Show / Hide |
Range on Protein: 383-428 Range on HMM: 102-147/165 Sequence Identity: 30% (14 aa) KHGSKCLVHCKMGVSRSASTVIAYAMKEYGWNLDRAYDYVKERRTV ..| . |||. || ||.. | . . ||.| . .. .| | ekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpv |
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