• Phosphatome.Net

Gene STYX

STYX
Species: Human
Alias: FLJ42934, STYX
External Links: COSMIC , Entrez Gene
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: DSP
Subfamily: STYX
Protein domain

Protein domains of STYX.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase STYX.AA Family.DSP.PD 25-183 31 2.2e-35 113.2 In-house 103-256 (387) Show / Hide 
Range on Protein: 25-183
Range on HMM: 103-256/387
Sequence Identity: 31% (49 aa)

MRREMQEILPGLFLGPYSSAmkSKLPVLQKHGITHIICIRQNiEANFIKpnfQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGI
....||||.|.||. . |  ..|. |...|.|.|. . .. . .| |   .. ..|| . | |...... ..|    .||. . . .|.||||.||..||
engkpseilphlylgsllaa--knlewlkelgvtkivnltdd-kpqftk---elgikylripidDhnapplenlfekaidfieegndskgvVlVHCkaGk

SRSAAFVIAYIMETFGMKYRDAFAYVQERRF-CINPNAGFVHQLQEYEAIYLAKLTIQMM
.  .|||.|.  |... .|...|...|  .|.|| ||..||...|  .|   ...|.   
gRsgtliiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekeklkvssevme
Phosphatase STYX.AA Subfamily.STYX.PD 28-173 83 1.1e-93 301.3 In-house 1-146 (146) Show / Hide 
Range on Protein: 28-173
Range on HMM: 1-146/146
Sequence Identity: 83% (122 aa)

EMQEILPGLFLGPYSSAMKSKLPVLQKHGITHIICIRQNIEANFIKPNFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRS
|||||||||||||||.||||||.||..||||||.|||||||||.|||||.. |||||||.|||.||||||..|..|||||.|||.|||||||||||||||
emqeilpglflgpysaamksklevlkehgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrs

AAFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAI
||.||||||||.|.|||.|||||||||||||||.|||.||.|||||
aalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeai
Phosphatase STYX.AA DSPc 28-173 36 8.9e-66 225.75 SMART 1-172 (172) Show / Hide 
Range on Protein: 28-173
Range on HMM: 1-172/172
Sequence Identity: 36% (63 aa)

EMQEILPGLFLGPYSSAMKSKLPVLQKHGITHIICIRQNIEANFIKP------------NFQQLFRYLVLD-IAD-------NPVENIIRFFPMTKEFID
...||.|.|.|| |...|..... |.||.|||.|.  .....||...            .... |.|. .  | |       |...||  .||....||.
GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH

GSLQMGGKVLVHGNAGISRSAAFVIAYIMETFGMKYRDAFAYV-----QERR-FCINPNAGFVHQLQEYEAI
 . | |||||||  |||||||...|||.| ...|.|.||...|     ..|| ..|.||..|.|||.|.| .
DCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK
Phosphatase STYX.AA DSPc 36-173 40 9.2e-58 202.76 Pfam 1-151 (151) Show / Hide 
Range on Protein: 36-173
Range on HMM: 1-151/151
Sequence Identity: 40% (62 aa)

LFLGPYSSAMKSKLPVLQKHGITHII-CIRQNIEANFIKPNFQQLFRYL-VLD------IADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRS
|.|| |...| .... ||||||||.| |.. . ...|.... .. ...  |.|      |..|...||  .||| ..|||   | ||||||| .||||||
LYLGSYPHHM-ADPAFLQKHGITHVINCTMECPNNWFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRS

AAFVIAYIMETFGMKYRDAFAYV-----QERR-FCINPNAGFVHQLQEYEAI
|...|||.| ...|.|..|...|     ..||  .|.||..| .||.||| .
ACLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ
Phosphatase STYX.AA Subfamily.DSP19.PD 29-172 37 9e-41 129.5 In-house 2-138 (139) Show / Hide 
Range on Protein: 29-172
Range on HMM: 2-138/139
Sequence Identity: 37% (53 aa)

MQEILPGLFLGPYSSAMKskLPVLQKHGITHIICIRQNIEANfikpnFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSA
..|. | |.||  ..|..  . .|.|..||||. .  ...       | . |.|. ..| |.| ........ . .||. ... .| |||||||.||||.
vaevkprlylgsqdvaad--keilkklkitHilnvavgvpnv-----fpkdftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsa

AFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEA
.||||.|..  .....|. .|.| | ||.||.||..||.|||| 
svviaylmkdeelslekalekvrearpcikPneGFikqLkeyea
Phosphatase STYX.AA Subfamily.DSP1.PD 30-171 39 4.1e-40 127.6 In-house 3-137 (139) Show / Hide 
Range on Protein: 30-171
Range on HMM: 3-137/139
Sequence Identity: 39% (55 aa)

QEILPGLFLGPYSSAmkSKLPVLQKHGITHIICIRQNieanfIKPNFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSAA
|||. |.||  ..|  |.| .|....||... . ..     ..  |..||.|  . . ||. ..|  .|    .|||   . ||.|||| .|||||||..
veildfLyLGsaeha--snlqlLkelkitallnvsae-----lpnvfeelfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsat

FVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYE
|.||.|..  .....|| .|..|| .|.|| |||.|| |.| 
ivlayLmkekkvrleeafefvkqrrsiisPnfgfvgqLlefe
Phosphatase STYX.AA Subfamily.LRR-DSP.PD 30-172 37 1e-35 113.1 In-house 3-136 (137) Show / Hide 
Range on Protein: 30-172
Range on HMM: 3-136/137
Sequence Identity: 37% (54 aa)

QEILPGLFLGPYSSAMKSklPVLQKHGITHIICIrqnieANfIKPNFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGkVLVHGNAGISRSAA
..|...|.||   |||    ..|.. ..|||...     |. .|| . .||.||..|| | .  .| ..|  .  |||   . || ||.|  ||.||||.
dliidklylgcresamnk--silkdnnvthilav-----ad-fkplypdlfkyliidiedvdeadiyqhfkemnafidegrekgg-vlihcragvsrsat

FVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEA
 ||||.|    .|...|.  |...|  |.|| ||..||. .|.
lviaylmkknslkfkealdlvikkrpriypnrgfldqlkkfek
Phosphatase STYX.AA Subfamily.DSP12.PD 28-173 32 3.7e-35 111.6 In-house 1-141 (143) Show / Hide 
Range on Protein: 28-173
Range on HMM: 1-141/143
Sequence Identity: 32% (47 aa)

EMQEILPGLFLGPYSSAMKskLPVLQKHGITHIICIRQNIEANFIKPNFQQLfryLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRS
|..||||||.||  . ...     |..  |||.. . ..   .. | . ..    ....|.|.| |....... . .||. .|. .|.|||| .||.|||
evseilpglylggleavqe--rellkelkithvlsvikeelpelqkekgvks---kliqilDepeedlLshldeavrFieeglekegavlvHClagvSRS

AAFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAI
...||||.| . ... ..|.  |.| .  |.||.||..||. .|..
vtiviAYlmkkeklslekAlklvkekkkeiepNegFleQLklfekm
Phosphatase STYX.AA Subfamily.DSP15.PD 29-172 39 5.3e-35 110.9 In-house 2-137 (138) Show / Hide 
Range on Protein: 29-172
Range on HMM: 2-137/138
Sequence Identity: 39% (55 aa)

MQEILPGLFLGPYSSAMKSKlpVLQKHGITHIICIRQNIeanfiKPNFQQlFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSA
|...||||..| .  | ...   |... ||||..| ..      || ... ..|| . .|| |  ....||  . .||  .   ||.|||||||||| . 
mnkvlpGlyvGnfrdakdke--qleenkithilsihdsa-----kplled-ikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsv

AFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEA
|.||||    ....||.  |.  | . |||.|| .||||.|   
tlvvayimtvtelswedalkavkaarsvanPnvGfrrqlqefek
Phosphatase STYX.AA Subfamily.DSP8.PD 30-172 37 1e-33 106.8 In-house 3-140 (143) Show / Hide 
Range on Protein: 30-172
Range on HMM: 3-140/143
Sequence Identity: 37% (53 aa)

QEILPGLFLGPYSSAMKSKlpVLQKHGITHIICIRQNIEanfIKPNFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSAA
..||| |.||    .....  .|.| ||.... | .. .   .......  |.| . . |.  |... .|... ||||   .  |||||||||||||. .
trilpnlylGsqkdsldee--llkklgisyvlnisescp---kdvellkesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsat

FVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEA
||||| |. |.. .|. .|.|.|  |.||  |. || |||   
vaiayimktlemsldeayrfvkekrptispnlnflgqLleyek
Phosphatase STYX.AA Subfamily.Slingshot.PD 32-173 37 4.4e-33 104.5 In-house 5-139 (139) Show / Hide 
Range on Protein: 32-173
Range on HMM: 5-139/139
Sequence Identity: 37% (53 aa)

ILPGLFLGPYSSAmkSKLPVLQKHGITHIICIRQNIEaNFikpnFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSAAFV
|   |.||    |  |.|  |...|...|. . ..|. ||    |.. |.|| . . |.. .......  | .||. . . | |||||   |.||||. |
ifdhlylGsewna--snleelkengveyilnvtkeid-nf----fpekfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastv

IAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAI
||| | ...... .|..||.||| .|.||.||..||..|| |
iayamkeyelsleealeyvkerrsiikpnkgflkqlkvyegi
Phosphatase STYX.AA Subfamily.DSP6.PD 31-172 34 1.6e-32 102.7 In-house 4-140 (141) Show / Hide 
Range on Protein: 31-172
Range on HMM: 4-140/141
Sequence Identity: 34% (49 aa)

EILPGLFLGPYSSAMksKLPVLQKHGITHIICIRQNIEANFIKpnfQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSAAF
|||| |.||   .|.  .| ||.|..| ... . .|..  | .   .. ..|. . | |.  .|. .||| . |||| . .   |||||  ||.||| . 
eilpllylGsakdas--nlevlkklkikyvlnvtsnlpnkfee---sgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtv

VIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEA
..||.|..  .   ||...|....  | ||  |. || ..| 
tlaylmkklalslndaydlvkkkksnisPnfnfmgqlldfer
Phosphatase STYX.AA Subfamily.DSP10.PD 29-172 34 5e-32 101.2 In-house 2-140 (141) Show / Hide 
Range on Protein: 29-172
Range on HMM: 2-140/141
Sequence Identity: 34% (49 aa)

MQEILPGLFLGPYSSAMKSKlpVLQKHGITHIICIRQNIEANFIKpnfQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSA
. .||| |.||    | . .  .|...||.... . ... ..| .   ..|.||  ... |.. .|. . |  . |||.   . |..||||.|||||||.
assilpflllGnekdaadkd--aldrlgikyvlnvttsvPnffee---kglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsa

AFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEA
 ||||.|. ...  ..|. .|.|.|  | || .|. || |.|  
tvviayvmkhlslslseaykfvkekrPiisPnlnfmGqllefek
Phosphatase STYX.AA Subfamily.DSP14.PD 29-171 31 1.4e-31 99.9 In-house 2-136 (138) Show / Hide 
Range on Protein: 29-171
Range on HMM: 2-136/138
Sequence Identity: 31% (44 aa)

MQEILPGLFLGpYSSAMKSKlpVLQKHGITHIICIRQnieaNFIKPNFQQlFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSA
. || . |.|.  ..|.| .  .|.|..||.|. . .    .  ...... .... . ..|.| ... ..| .. . |.   . |||.|||||.||||..
lseitesLyls-gaaalkke--klkkkkitlivnvtt----elpetkled-vktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsA

AFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYE
|.||.|    .  |.|. .|...|  |.|| || .||..||  
slvlaylmkyeklsLreayklvksaRpiirPnvGFwkqlidyE
Phosphatase STYX.AA Subfamily.DSP3.PD 29-171 31 5.9e-30 94.6 In-house 2-146 (148) Show / Hide 
Range on Protein: 29-171
Range on HMM: 2-146/148
Sequence Identity: 31% (46 aa)

MQEILPGLFLGPYSSAMKSKlpVLQKHGITHIICIRQNIE---ANFIKPNFQQ-LFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQM-GGKVLVHGNAG
..|. |....|  ..|.. .   |.| ||||..   .. .    .  .  ...   .|| ... | |  .. ..|    .||| .|.  .|||||| ..|
vdevypkvyvgdeavakdke--kLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvG

ISRSAAFVIAYIMETFGMKYRDAFAYVQERRfCINPNAGFVHQLQEYE
|||||. |.||.| .  .. ..|   |...| .| || ||..|| |..
isRsatlvlayLmirrkltlkeaiktvrkkr-eilPneGflkqLleld
Phosphatase STYX.AA Subfamily.STYXL1.PD 31-171 28 2.4e-22 70.2 In-house 4-141 (143) Show / Hide 
Range on Protein: 31-171
Range on HMM: 4-141/143
Sequence Identity: 28% (40 aa)

EILPG-LFLGPYSSAMKSKLPvlQKHGITHIICIRQNIEAnfIKPNFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSAA
|.||| |.|| |. |.. ..   .   .   . . .. |   .    ..  . | ... |..  ... ..    .||.   . |  |||.| ||||||| 
evlPgklylGnykqaqnpaik--kdlkvkahvnvssdaek--liagladvakllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaa

FVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYE
.|||.|    .....|..|... .  ..|| .||.||.|.| 
viiaylmyskkitlkkaykylkkckenvkPnrafveqlseWe
Phosphatase STYX.AA Subfamily.PTPMT1.PD 52-171 20 8.2e-13 38.9 In-house 20-144 (146) Show / Hide 
Range on Protein: 52-171
Range on HMM: 20-144/146
Sequence Identity: 20% (26 aa)

L-QKHGITHIICIRQNIEANFIKPNFQQL-------FRYLVLDIADNPVENIIRffpMTKEFIDGSLQMGGKVLVHGNAGISRSAAFVIAYIMETFGMKY
| .|. .  .... .. | ... .. ..        ... . |... |  . ..    . |||.   . | .| ||  || .|||. |..|.|..  .. 
LvekenvkavvslneeyelkalansteewkklGveqlqlatvDfteapslekle---egvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklsp

RDAFAYVQERRFCINPNAGFVHQLQEYE
 .|  .....|  |  .   .. |||..
eeavkflkkkRpqirlkskqwralqefk
Phosphatase STYX.AA Subfamily.Laforin.PD 78-151 24 4.4e-09 26.7 In-house 69-142 (165) Show / Hide 
Range on Protein: 78-151
Range on HMM: 69-142/165
Sequence Identity: 24% (18 aa)

QLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSAAFVIAYIMETFGMKYRDAFAYVQ
. . |. | . |   |. .. .| .  .. . |. | .| || |||. ||.| |  ...  .| . .    .. 
eglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfll
Phosphatase STYX.AA Subfamily.CDC14.PD 102-153 20 4.8e-09 26.7 In-house 187-238 (258) Show / Hide 
Range on Protein: 102-153
Range on HMM: 187-238/258
Sequence Identity: 20% (10 aa)

TKEFIDGSLQMGGKVLVHGNAGISRSAAFVIAYIMETFGMKYRDAFAYVQER
|.|.. . .. |.. ||  ||. | .... .|.. .....  .. |...   
lkkfleitekaeGaiavhCkaGLGrtgtligcylikhyrftaaetiawlria
Phosphatase STYX.AA Subfamily.PRL.PD 43-170 23 5.8e-08 23.2 In-house 12-136 (140) Show / Hide 
Range on Protein: 43-170
Range on HMM: 12-136/140
Sequence Identity: 23% (30 aa)

SAMKSKLPVLQKHGITHII-CIRQNIEANFIKPNFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSlqMGGKVLVHGNAGISRSAAFVIAYIMETfGM
..... . .|.|. ..... .  .. .|. .| .  ..  .   | |  | | . ... . ||    .   .  | ||  ||. |.  .|..|. ||||.
etvekfieelkkenvkevvrvcepsydaeklkeegievldlafddGavPpkevvdeWlellkekfkee--pkstvavhcvaGlGraPvlvalaliea-Gm

KYRDAFAYVQERR-FCINpnAGFVHQLQEY
||  ...|.|  .||  .  .. |..|   
kyedavefirekrrgain--skqlkfleky
Phosphatase STYX.AA Subfamily.DSP11.PD 93-168 20 2.3e-06 18.0 In-house 61-136 (141) Show / Hide 
Range on Protein: 93-168
Range on HMM: 61-136/141
Sequence Identity: 20% (16 aa)

ENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSAAFVIAYIMETFGMKYRDAFAYVQE-RRFCINPNAgFVHQLQ
|.. .|  . |||.. . . .  . ||   |. |.  ..  |.... |..  ||    .| | .... .. ....|.
edvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyspedaieafeearGhsleren-yledLk
Phosphatase STYX.AA Subfamily.R_Nematode_3.PD 115-135 45 8.2e-06 15.8 In-house 200-220 (267) Show / Hide 
Range on Protein: 115-135
Range on HMM: 200-220/267
Sequence Identity: 45% (9 aa)

KVLVHGNAGISRSAAFVIAYI
|.||  .||||||... . . 
pvvVHCsdGisRsatlaaiel
Sequence
Name Sequence Type Origin Length Description Download
STYX.AA Protein None 223 None Fasta, JSON
STYX.NA RNA None 669 None Fasta, JSON
STYX.AA.PD_28-179 Protein Phosphatase Domain None 152 None Fasta, JSON