Gene TENC1
TENC1
Species: Human
Alias: DKFZp686D13244, TENC1, C1-TEN, C1TEN, TNS2, FLJ16320, KIAA1075
External Links:
COSMIC
,
Entrez Gene
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of TENC1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| C1 | TENC1.AA | C1 | 42-89 | 28 | 1.1e-12 | 49.42 | SMART | 1-61 (61) | Show / Hide |
Range on Protein: 42-89 Range on HMM: 1-61/61 Sequence Identity: 28% (18 aa) HSFREKVFRKKPPVCAVCKVTIDGT--------GVSCRVCKVATHRKCEAKVTS-------AC |..... | || |..|. .| | |..|..||.. | || .||.. .| HHWHWWRF--KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC |
|||||||||
| Phosphatase | TENC1.AA | Subfamily.PTEN.PD | 142-307 | 28 | 5.1e-30 | 93.2 | In-house | 1-165 (305) | Show / Hide |
Range on Protein: 142-307 Range on HMM: 1-165/305 Sequence Identity: 28% (46 aa) DLTYVTERILAAAFPARPDEQRHRGHLRELAHVLQSKHRDKYLLFNLSEKR-HDLTRLNPKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQHVVVLY |..|. ... ..|. |. . . .|......|. | .|. .. .. . .. .|. .. ..|.|. | .|.. ...||..|..||.. | disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavH CKGNKGKLGVIVSAYMHYSKISAGADQALATLTMRKFCEDKVATelQPSQRRYISYFSGLLSGSIRM | ||. ||...||. .|.| ||.||| . .. . | | ||||||..||| |. |. CkaGkGRtGvmicayLlksgikksadealaiydekRtkdkkGVt--iPSQrRYvqYfsklvkssvpy |
|||||||||
| C1 | TENC1.AA | C1_1 | 42-92 | 26 | 4e-06 | 26.3 | Pfam | 1-55 (55) | Show / Hide |
Range on Protein: 42-92 Range on HMM: 1-55/55 Sequence Identity: 26% (15 aa) HSFREK-VFRKKPPVCAVCKVTIDG----TGVSCRVCKVATHRKCEAKVTSACQAL | .... | |.| |..|. . | .|..|..|.. | .| ||.. |. HHWVHHWNF-KQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN |
|||||||||
| Phosphatase | TENC1.AA | Subfamily.Tensin.PD | 198-434 | 64 | 3e-131 | 424.3 | In-house | 1-237 (237) | Show / Hide |
Range on Protein: 198-434 Range on HMM: 1-237/237 Sequence Identity: 64% (154 aa) LNPKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQHVVVLYCKGNKGKLGVIVSAYMHYSKISAGADQALATLTMRKFCEDKVATELQPSQRRYISYF ||.||.|.|||.|.||||.||||||||.|.||.||||.||||.|||.||..||..|||||||||||.||.||.......|..|||....|||||||..|| lnekvldlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyf SGLLSGSIRMNSSPLFLHYVLIPMLPAFEPGTGFQPFLKIYQSMQLVYTSGVYHIAGPGPQQLCISLEPALLLKGDVMVTCYHKGGRGTDRTLVFRVQFH ||||||||..||||||||||.....|.|....|..|||||||..|||||||||..||.....|||..||||||||||.|.|||| |.|.|..||||||| sgllsgsiklnssplflhyvilhgipnfdskggcrpflkiyqalqlvytsgvynvagedterlcitiepalllkgdvlvkcyhkklrsttrdvvfrvqfh TCTIHGPQLTFPKDQLDEAWTDERFPFQASVEFVFSS |..|.. .|.|.|..||||..|||||..|.||.|||. tgaikdlklvfekedldealkderfpeyakvelvfsa |
|||||||||
| Phosphatase | TENC1.AA | PTEN_C2 | 307-434 | 38 | 2.4e-42 | 151.78 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 307-434 Range on HMM: 1-141/141 Sequence Identity: 38% (54 aa) MNSSPLFLHYVLI-PMLPAFEPGTGF-QPFLKIYQSMQLV-YTSGVYHIAGPG-PQQLCISLEP-ALLLKGDVMVTCYHKG-GR--GTDRTLVFRVQFHT ....||||| . . .| |. | |. |...||| .| | ||.. |... . |. || ..| ....|||.. ||||| .. . ..||..|.| PPPKPLFLHCIIMDHGIPNFKQGGGCWRPYIQIYQNDQKVFYTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYEECMFRFWFNT CTIH--GPQLTFPKDQLDEAWTD---ERFPFQASVEFVFSS | |. ...|||||..|| || | .||| . .||.||| CFIEHNNNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE |
|||||||||
| Phosphatase | TENC1.AA | Family.DSP.PD | 188-439 | 22 | 2e-36 | 114.4 | In-house | 148-381 (387) | Show / Hide |
Range on Protein: 188-439 Range on HMM: 148-381/387 Sequence Identity: 22% (53 aa) LsekrhdltRLNPKVQDFGWPELHAPPLDKLcsICKAMEtWLSA--DPQHVVVLYCKGNKGKLGVIVSAYMHYS-KISAGadQALATLTMRKfcedkvAT .|. |. ..... .||||..| ..||.. ... |...||. ||. || |....||...| .... .||. . ....|.|. ...... |.. k--------elgikylripidDhnapplenl--fekaid-fieegndskgvVlVHCkaGkgRsgtliiaYlmksegltle--ealdwvrskR------pg ELQPSQRrYISYFSGLLSGSIRMNSSPLFLHYVLIPMLPAFEPGTGFQPFLKIYQSMQLVYTSGVYhIAGPGPQQLCISLEPALLLKGDVMVTCYHKGGR . ..|....|. | . . . . ..|| .. ........ . ....| ....| | ||| |...| | ......|.| |. vitpnqg-flkqlkdlekeklkvssevmelrfvissivqnlgsvevsvsvlkkvatekakldrlki-LvideqekvvitikdglplsgDVkvelfkknld GTDRTLVFRVQFHTCTIHGPQLTFPKDQLDEAWTDERFPFQASVEFVFSSSPEKI .| .| .|||. ...|. . .|.|..| .|| kiirdiilntfFvtnyikdeslvlvkkeldelhkskifdvykdseaveiseefki |
|||||||||
| SH2 | TENC1.AA | SH2 | 1148-1248 | 26 | 1.7e-18 | 68.65 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 1148-1248 Range on HMM: 1-87/87 Sequence Identity: 26% (28 aa) KFWYKPHLSRDQAIALLKD--KDPGAFLIRDSHSFQGAYGLALKVATPPPSAQPWKGDPVEQLVRHFLIETGP-KGVKIKGCPSEPYFGSLSALVSQHSI || ..||..| .||| . .|.||.||| |. |.| | ... . |.|..|.. . ... | .. ....| || || .. QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK---------------GKVKHYRIRRNDDGKYYIDET-WRRKFPSL-ELVNHYQH SPIS |.. NPLG |
|||||||||
| Phosphatase | TENC1.AA | Subfamily.TPIP.PD | 212-300 | 32 | 2.5e-17 | 51.6 | In-house | 15-106 (245) | Show / Hide |
Range on Protein: 212-300 Range on HMM: 15-106/245 Sequence Identity: 32% (30 aa) APPLDKLCSICKAMETWLSADPQHVVVLYCKGNKGKLGVIVSAYMHYSKISAGADQALATLTMRKFCE---DKVATELQPSQRRYISYFSGL | |..| ...| .. ||..|...||...||| ||. | || |.. .|.| |...| .. |. . .| |||.||..|. . vPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryvgylaqv |
|||||||||
| Phosphatase | TENC1.AA | Subfamily.PTPDC1.PD | 191-273 | 20 | 7.6e-08 | 20.4 | In-house | 126-204 (229) | Show / Hide |
Range on Protein: 191-273 Range on HMM: 126-204/229 Sequence Identity: 20% (17 aa) KRHDLTRLNPKVQDFGWPELHAPPLDKLCSICKAMETWLsadPQHVVVLYCKGNKGKLGVIVSAYMHYSKiSAGADQALATLT . .| | . . ||... ...|... | | .. | . . ..| .|. ||....|. |.| .|..|. .. dpeelmrqgiyfynfglkDygvasleriLdivkvvdfal---eegkiavHCHAGlGRtGvliacylvyak-rltaeeaiklvr |
|||||||||
| PTB | TENC1.AA | PTB | 1281-1419 | 21 | 2.2e-30 | 108.19 | SMART | 1-153 (156) | Show / Hide |
Range on Protein: 1281-1419 Range on HMM: 1-153/156 Sequence Identity: 21% (35 aa) RQGAACSVLYLTSVETESLT-------GPQAVARASSAALSCSPRPTPAVVHFKVSAQGITLTDNQRKLFFRRHYPVNSITFSSTDPQDRRWTNPDGT-- .|....|.|| .||... . |.|..... . . .... .|...| .|..|.|.|.| ....|.|...|.|.. ||. | | |. |. PWGCCFNVWYLGCVEVPHHRNSMAPGKGMQVCQECMRKIR--QHWKHWQKMHLHISVDGVKLIDPQTK-QVIHHHPIHRISFCAHDPY-R-W-NT-GGHH ---TSKIFGFVAKKPGS------PWENVCHLFAELDPD---QPAGAIVTFITKVLLGQRK ....||.....|.. ... ||.| || ... .. | ... . |.. CCDDDRCFGYICRHPNDRGSHRMTYWFRCHVFWCEDPHAEDIAQTIGQAFQVCYQQCQKQ |
|||||||||
| SH2 | TENC1.AA | SH2 | 1150-1242 | 29 | 2.4e-15 | 46.89 | Pfam | 1-81 (81) | Show / Hide |
Range on Protein: 1150-1242 Range on HMM: 1-81/81 Sequence Identity: 29% (28 aa) WYKPHLSRDQAIALLKD--KDPGAFLIRDSHSFQGAYGLALKVATPPPSAQPWKGDPVEQLVRHFLIETGPKG-VKIKGCPSEPYFGSLSALVSQH || ...|| .| ||. . .|.||.|.| | .| | | .. | .. |.|. | . . | . | | ...|.||. ||. . WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP------------GDRVKHYRIQRTDNGGYYITG---RHKFCSLQELVEHY |
|||||||||
| PTB | TENC1.AA | PTB | 1285-1418 | 41 | 5.5e-71 | 246.93 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 1285-1418 Range on HMM: 1-141/141 Sequence Identity: 41% (58 aa) ACSVLYLTSVETESLTGPQAVAR--ASSAALSCSPRPTPAVVHFKVSAQGITLTDNQRKLFFRRHYPVNSITFSSTDPQDRRWTN-PDGTTSKIFGFVAK .. |..|......|.||.|.| . .... .....|......||.||.|.||||||..|.|||.|||.|||......|.|.||.. .|....|||.||.. QYHVEHLMTCDMDSRTGMQCVEDCIRKLQMMDAQGRVWTQDMHFQVSDQHITLTDNETKEFFREHYPLNSIRHCQAVPNDCRWNSTRDHDQAKIFAFVCQ KPGSPWENVCHLFA--ELDPDQPAGAIVTFITKVLLG--QR .|.....||||.|. |||..||. .|..||.|..|| || EPHQSKPNVCHFFQCDELDAEQPHEDIEKFIHKCMLGKKQR |
|||||||||