Gene TNS3
TNS3
Species: Human
Alias: TEM6, TENS1, DKFZp686M1045, FLJ13732, H_NH049I23.2, DKFZp686K12123, FLJ35545, MGC88434, TNS3
External Links:
COSMIC
,
Entrez Gene
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of TNS3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | TNS3.AA | Subfamily.PTEN.PD | 8-174 | 26 | 1.8e-34 | 109.7 | In-house | 1-166 (305) | Show / Hide |
Range on Protein: 8-174 Range on HMM: 1-166/305 Sequence Identity: 26% (45 aa) DLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNLS-EKRYDLTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNLQHVVVIH |..|| .|..|.|. |. . .| ... ..|.... ... . .|. ..... .... ... .. ..|.|. . .|.. ..||.....||..|| disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavH CRGGKGRIGVVISSYMHFTNVSASADQALDRFAMKKFYDDkvSALMQPSQKRYVQFLSGLLSGSVKMN . |||| ||.|..|. ... |||.||. .. |.. | . |||.||||. | |. || . CkaGkGRtGvmicayLlksgikksadealaiydekRtkdk--kGVtiPSQrRYvqYfsklvkssvpys |
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| Phosphatase | TNS3.AA | Subfamily.Tensin.PD | 64-300 | 71 | 2.6e-136 | 442.9 | In-house | 1-237 (237) | Show / Hide |
Range on Protein: 64-300 Range on HMM: 1-237/237 Sequence Identity: 71% (169 aa) LNPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNLQHVVVIHCRGGKGRIGVVISSYMHFTNVSASADQALDRFAMKKFYDDKVSALMQPSQKRYVQFL ||.|..|.|||.|.||||.|.|.||||.||||....|.|||.||.|||||||||||.|||....|||||.||||||.|.|||||||...||||.|||... lnekvldlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyf SGLLSGSVKMNASPLFLHFVILHGTPNFDTGGVCRPFLKLYQAMQPVYTSGIYNVGPENPSRICIVIEPAQLLKGDVMVKCYHKKYRSATRDVIFRLQFH |||||||.|.|.||||||.|||||.||||..|.||||||.|||.|.|||||.|||..|...|.||.||||.||||||.|||||||.||.||||.||.||| sgllsgsiklnssplflhyvilhgipnfdskggcrpflkiyqalqlvytsgvynvagedterlcitiepalllkgdvlvkcyhkklrsttrdvvfrvqfh TGAVQGYGLVFGKEDLDNASKDDRFPDYGKVELVFSA |||.....|||.|||||.|.||.|||.|.|||||||| tgaikdlklvfekedldealkderfpeyakvelvfsa |
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| Phosphatase | TNS3.AA | Family.DSP.PD | 29-305 | 25 | 3.7e-51 | 164.9 | In-house | 114-381 (387) | Show / Hide |
Range on Protein: 29-305 Range on HMM: 114-381/387 Sequence Identity: 25% (70 aa) SYLHNLQEVTRMLKSKHGDNYLVLNLSEKRYDLTK-LNPKIMDVGWPELHAPPLDKMctICKAQEsWLNS--NLQHVVVIHCRGGKGRIGVVISSYMHFT || .|. .. . |. ..||.... || |. |....... .||||... ..|| . .... . ..||..|| .|||| |..|. |... lylgsllaaknlewlkelgvtkivnltddkpqftkelgikylripidDhnapplenl--fekaid-fieegndskgvVlVHCkaGkgRsgtliiaYlmks -NVSASadQALDRFAMKKfyddkvSALMQPSQKrYVQFLSGLLSGSVKMNASPLFLHFVILHGTPNFDTGGVCRPFLKLYQAMQPVYTSGIYNVGpENPS ..... .||| .. |. . .|.|. ... |. |.. .|.. ....|.||| .. .|.. .|. ..|| .. . .....| .. ...| egltle--ealdwvrskR------pgvitpnqg-flkqlkdlekeklkvssevmelrfvissivqnlgsvevsvsvlkkvatekakldrlkiLvi-deqe RICIVIEPAQLLKGDVMVKCYHKKYRSATRDVIFRLQFHTGAVQGYGLVFGKEDLDNASKDDRFPDYGKVELVFSATPEKI |... | ||| |....| . ||.|.. .|.|.... || |..||...|...|..| ..| |... .|| kvvitikdglplsgDVkvelfkknldkiirdiilntfFvtnyikdeslvlvkkeldelhkskifdvykdseaveiseefki |
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| Phosphatase | TNS3.AA | PTEN_C2 | 173-300 | 38 | 1.8e-50 | 178.79 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 173-300 Range on HMM: 1-141/141 Sequence Identity: 38% (54 aa) MNASPLFLHFVIL-HGTPNFDTGGVC-RPFLKLYQAMQPV-YTSGIYNVGPEN-PSRICIVIEPAQLL-KGDVMVKCYHKK-YR--SATRDVIFRLQFHT .. .||||| .|. || |||..||.| ||... || .|.| ||...|. . .. ..||...|.... .|||...||||. . . .....||..|.| PPPKPLFLHCIIMDHGIPNFKQGGGCWRPYIQIYQNDQKVFYTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYEECMFRFWFNT GAVQ--GYGLVFGKEDLDNASKD---DRFPDYGKVELVFSA . .. .. | | |..||.| || .|||.. |||.||| CFIEHNNNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE |
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| SH2 | TNS3.AA | SH2 | 1170-1273 | 27 | 3e-21 | 77.85 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 1170-1273 Range on HMM: 1-87/87 Sequence Identity: 27% (29 aa) KFWYKADISREQAIAMLKD--KEPGSFIVRDSHSFRGAYGLAMKVATPPPSVLQLNKKAGDLANELVRHFLIECTP-KGVRLKGCSNEPYFGSLTALVCQ || .||||.| ..|| ...|.|.|||| |..|.| | ... . |.|..|.... ..... .. ....| || || QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK------------------GKVKHYRIRRNDDGKYYIDET-WRRKFPSL-ELVNH HSITPLA .. .|| YQHNPLG |
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| Phosphatase | TNS3.AA | Subfamily.TPIP.PD | 78-289 | 25 | 4.3e-21 | 65.9 | In-house | 15-231 (245) | Show / Hide |
Range on Protein: 78-289 Range on HMM: 15-231/245 Sequence Identity: 25% (53 aa) APPLDKMCTICKAQESWLNSNLQHVVVIHCRGGKGRIGVVISSYMHFTNVSASADQALDRFAMKK---FYDDKVSALMQPSQKRYVQFLSGLLSgSVKMN | |... ...| . ||. .|..||.|||.||||| | .. ... ... |...|| |. .. .| . |||.|||..| .. | | . vPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryvgylaqvkh-lynwn ASPLFLHFVILHGTPNfDTGGVCRPFLKLYQAMQPVYTSGIY-NV---GPENPSRICIVIEPAQLLKGDVMVKCYHKKYRSATRDVIFRLQFHTGAVQGY |. . | || ... . |..| |. . .| | . . | || |. . ... | . | | .| |.. ...||| lpprrilfikrfiiys-irgdvcdlkvqvvmekkvvfsstslgncsilhdietdkilinvydgpplyddvkvqffssnlpkyydncpfffwfntsfiqnn GLVFGKEDLDNASKDDRFP |. . rlclprneldnphkqkawk |
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| Phosphatase | TNS3.AA | Subfamily.PTPDC1.PD | 60-137 | 22 | 1.1e-09 | 28.4 | In-house | 129-202 (229) | Show / Hide |
Range on Protein: 60-137 Range on HMM: 129-202/229 Sequence Identity: 22% (17 aa) DLTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLnsnLQHVVVIHCRGGKGRIGVVISSYMHFTNvSASADQALDR .| . . .. .|... ...|... .| | .. | .. . .|| |.|| ||.|..|. ... .|..|.. elmrqgiyfynfglkDygvasleriLdivkvvdfal---eegkiavHCHAGlGRtGvliacylvyak-rltaeeaikl |
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| Phosphatase | TNS3.AA | PTPc_motif | 64-186 | 14 | 7e-06 | 17.46 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 64-186
Range on HMM: 1-92/92
Sequence Identity: 14% (18 aa)
LNPKIMDVGWPEL-----HAPPLDKMCTICKAQESWLNSNLQHVVVIHCRGGKGRIGVVISSYMHFTNVSASADQALDRFAMKKFYDDKVSALMQPSQKR
.||. ..| | . ..... .. .|.|| | || |.... .| . .. .
TVHHYHYTNWPDHVEKDSGVPE-DSILEFIRHVRK--------PIVVHCSAGCGRTGTFCAIDMMMQQ---------------------------VDIFQ
YVQFLSGLLSGSVKMNASPLFLHFVILH
.|. . |.|.... .|.. .||
TVKEMRKQRPGMVQTEEQYIFCYRCILE
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| Phosphatase | TNS3.AA | Subfamily.N12.PD | 27-147 | 18 | 9.1e-06 | 15.3 | In-house | 126-247 (270) | Show / Hide |
Range on Protein: 27-147 Range on HMM: 126-247/270 Sequence Identity: 18% (23 aa) EESYLHNLQEVTRMLKSKHGDNYLVLNLSEKRYDLTKLNPKIMDVGWPELHAPP-LDKMCTICKAQESWLNsNLQHVVVIHCRGGKGRIGVVISSYMHFT ||. .. ||| . . . |..|. | .. . .. .. ||. | ... . .. .. . . .. .|.|| | || |..|. . . eeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhytaWPDhgvPssaksllelielvrelqe-sedaPlvvhCsaGvGrtGtiiaidyvre NVSASAD-QALDRFAMKKFYDDK . | . || | . . llkaekipeeldvfdlvlelrkq |
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| PTB | TNS3.AA | PTB | 1306-1443 | 22 | 1.5e-25 | 92.13 | SMART | 1-156 (156) | Show / Hide |
Range on Protein: 1306-1443 Range on HMM: 1-156/156 Sequence Identity: 22% (37 aa) KQGAACNVWYLNSVEMESLT-------GHQAIQKALSITLVQEPPPVSTVVHFKVSAQGITLTDNQRKLFFRRHYPVNSVIFCALDPQDRKWIKDGP--- .|...||||| .||... . | |..|.... . . . .|...| .|..|.|.|.| ....|.|.....||| ||. | | . | PWGCCFNVWYLGCVEVPHHRNSMAPGKGMQVCQECMRKIR--QHWKHWQKMHLHISVDGVKLIDPQTK-QVIHHHPIHRISFCAHDPY-R-WNT-GGHHC --SSKVFGFVARKQGS------ATDNVCHLFAEHDPE---QPASAIVNF---VSKVMIGSPK ...||...|.... .. . ||.| ||. ...... .| ... . .. CDDDRCFGYICRHPNDRGSHRMTYWFRCHVFWCEDPHAEDIAQTIGQAFQVCYQQCQKQRCQ |
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| SH2 | TNS3.AA | SH2 | 1172-1267 | 27 | 3.2e-13 | 40.66 | Pfam | 1-81 (81) | Show / Hide |
Range on Protein: 1172-1267 Range on HMM: 1-81/81 Sequence Identity: 27% (27 aa) WYKADISREQAIAMLKD--KEPGSFIVRDSHSFRGAYGLAMKVATPPPSVLQLNKKAGDLANELVRHFLIECTPKGVRLKGCSNEPYFGSLTALVCQH || .|||..| .|. ...|.|.||.| | | | | . | .. |.|. | .|. | .. ...|.|| || . WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP---------------GDRVKHYRIQRTDNG--GYYITGRHKFCSLQELVEHY |
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| PTB | TNS3.AA | PTB | 1310-1444 | 36 | 7.4e-73 | 253.15 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 1310-1444 Range on HMM: 1-141/141 Sequence Identity: 36% (51 aa) ACNVWYLNSVEMESLTGHQAIQK--ALSITLVQEPPPVSTVVHFKVSAQGITLTDNQRKLFFRRHYPVNSVIFCALDPQDRKWIK--DGPSSKVFGFVAR ...|..|....|.|.||.|.... . . .. ... . ....||.||.|.||||||..|.|||.|||.||...|...|.|..| . |....|.|.||.. QYHVEHLMTCDMDSRTGMQCVEDCIRKLQMMDAQGRVWTQDMHFQVSDQHITLTDNETKEFFREHYPLNSIRHCQAVPNDCRWNSTRDHDQAKIFAFVCQ KQGSATDNVCHLFA--EHDPEQPASAIVNFVSKVMIGSPKK .......||||.|. |.|.|||...|..|..|.|.|.... EPHQSKPNVCHFFQCDELDAEQPHEDIEKFIHKCMLGKKQR |
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