Gene TNS1
TNS1
Species: Human
Alias: MGC88584, TNS, MST127, MSTP127, MSTP122, MST122, DKFZp586K0617, MST091, MXRA6, TNS1
External Links:
COSMIC
,
Entrez Gene
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of TNS1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | TNS1.AA | Subfamily.PTEN.PD | 14-253 | 29 | 7.9e-39 | 122.9 | In-house | 1-241 (305) | Show / Hide |
Range on Protein: 14-253 Range on HMM: 1-241/305 Sequence Identity: 29% (70 aa) DLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLS-ERRPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWLNADPHNVVVLH |. |. .|..|.| . |. .. | .. ..|.... |.. | .|. ... . .... .| ... | . | || . .|.. .|.||..|.|||..| disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavH NKGNRGRIGVVIAAYMHYSNISASADQALDRFAMKRFYEDKIVPIgqPSQRRYVHYFSGLLSGSIKMNNKPLFLHHVIMHGIPNFESKGGCRPFLRI--Y | .|| ||.|.||. .|.| |||.||. .. ||. . | | | |||||||.||| |. |. .. | . . .. | . . | . CkaGkGRtGvmicayLlksgikksadealaiydekRtkdkkGVti--PSQrRYvqYfsklvkssvpyskvslnvceirfsesscvqnlgmvecsisvlhd QAMQPVYTSGIYNIPGDSQTSVCITIEPGLLLKGDILLKCYHK . .| | | |. .||.| . . ||. .. .| satenakpdrlktlpidfqksfvltikpsipvsgdvkfeltkk |
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| Phosphatase | TNS1.AA | Subfamily.Tensin.PD | 70-306 | 73 | 9.3e-140 | 453.0 | In-house | 1-237 (237) | Show / Hide |
Range on Protein: 70-306 Range on HMM: 1-237/237 Sequence Identity: 73% (174 aa) LHAKVLEFGWPDLHTPALEKICSICKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYMHYSNISASADQALDRFAMKRFYEDKIVPIGQPSQRRYVHYF |..|||..|||||..|.|||.||||||...||.|||.||||||.||..|||||||.||||||.||||||.||||||.||||.||.... ||||||||.|| lnekvldlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyf SGLLSGSIKMNNKPLFLHHVIMHGIPNFESKGGCRPFLRIYQAMQPVYTSGIYNIPGDSQTSVCITIEPGLLLKGDILLKCYHKKFRSPARDVIFRVQFH |||||||||.|..|||||.||.||||||.|||||||||.||||.|.|||||.||..|......||||||.||||||.|.||||||.||..|||.|||||| sgllsgsiklnssplflhyvilhgipnfdskggcrpflkiyqalqlvytsgvynvagedterlcitiepalllkgdvlvkcyhkklrsttrdvvfrvqfh TCAIHDLGVVFGKEDLDDAFKDDRFPEYGKVEFVFSY |.||.||..||.|||||.|.||.|||||.|||.|||. tgaikdlklvfekedldealkderfpeyakvelvfsa |
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| Phosphatase | TNS1.AA | Family.DSP.PD | 47-311 | 28 | 3.7e-55 | 176.9 | In-house | 140-381 (387) | Show / Hide |
Range on Protein: 47-311 Range on HMM: 140-381/387 Sequence Identity: 28% (71 aa) LkskhggnyllfnlsERRPDITK-LHAKVLEFGWPDLHTPALEKIcsICKAMDtWLNA--DPHNVVVLHNKGNRGRIGVVIAAYMHYS-NISASadQALD . .| .|| |. |.|.....| ..| ||.. ..||.| ... |...||. | |. .|| |..|.||...| ......||| .. || | . t--------------ddkpqftkelgikylripidDhnapplenl--fekaid-fieegndskgvVlVHCkaGkgRsgtliiaYlmksegltle--eald RFAMKRfyedkivP-IGQPSQRrYVHYFSGLLSGSIKMNNKPLFLHHVIMHGIPNFESKGGCRPFLRIYQAMQPVYTSGIYnIPGDSQTSVCITIEPGLL .|.|. ...... |.. .|.......|..||.....|. |.... ..|. .. . ..... .. | | .|.|||..|| | ||.......| . wvrskR-------pgvitpnqg-flkqlkdlekeklkvssevmelrfvissivqnlgsvevsvsvlkkvatekakldrlki-Lvideqekvvitikdglp LKGDILLKCYHKKFRSPARDVIFRVQFHTCAIHDLGVVFGKEDLDDAFKDDRFPEYGKVEFVFSYGPEKI ||.|....|.| .|.| | |..||.. |...|. | ..|.|.. .|| lsgDVkvelfkknldkiirdiilntfFvtnyikdeslvlvkkeldelhkskifdvykdseaveiseefki |
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| Phosphatase | TNS1.AA | PTEN_C2 | 179-306 | 41 | 4.5e-55 | 194.07 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 179-306 Range on HMM: 1-141/141 Sequence Identity: 41% (59 aa) MNNKPLFLHHVIM-HGIPNFESKGGC-RPFLRIYQAMQPV-YTSGIYNIPGDS-QTSVCITIEP-GLLLKGDILLKCYHKK-FR--SPARDVIFRVQFHT .. ||||||..|| ||||||...||| ||...||| .|.| ||...|... . |. ||...| .....||....||||. .. .. ....||..|.| PPPKPLFLHCIIMDHGIPNFKQGGGCWRPYIQIYQNDQKVFYTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYEECMFRFWFNT CAIH--DLGVVFGKEDLDDAFKD---DRFPEYGKVEFVFSY | |. . . | |..||.|.|| .|||.. |||.||| CFIEHNNNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE |
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| Phosphatase | TNS1.AA | Subfamily.TPIP.PD | 74-292 | 25 | 3.3e-21 | 65.2 | In-house | 5-228 (245) | Show / Hide |
Range on Protein: 74-292 Range on HMM: 5-228/245 Sequence Identity: 25% (57 aa) VLEFGWPDLHTPALEKICSICKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYMHYSNISASADQALDRFAMKRFY---EDKIVPIGQPSQRRYVHYFS | | | ||.. ...| .. ||..|..|||..| || .|| | .. |.. .|.| |...|| |. .| .| . |||.|||.|. vsrimiddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryvgyla GLLSgSIKMN---NKPLFLHHVIMHGIPNFEskggCRPFLRIYQAMQPVYTS---GIYNIPGDSQT-SVCITIEPGLLLKGDILLKCYHKKFRSPARDVI . . | . ||....|.. | | ... . |..| | .| | .| . | . | | |... . .. .. | qvkh-lynwnlpprrilfikrfiiysirgdv----cdlkvqvvmekkvvfsstslgncsilhdietdkilinvydgpplyddvkvqffssnlpkyydncp FRVQFHTCAIHDLGVVFGKEDLDDAFKDD . | |. |.. ... ...||. .|. fffwfntsfiqnnrlclprneldnphkqk |
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| SH2 | TNS1.AA | SH2 | 1461-1563 | 27 | 1e-18 | 69.44 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 1461-1563 Range on HMM: 1-87/87 Sequence Identity: 27% (29 aa) KYWYKPEISREQAIALLKD--QEPGAFIIRDSHSFRGAYGLAMKVSSPPPTIMQQNKKGDMTHELVRHFLIETGP-RGVKLKGCPNEPNFGSLSALVYQH || ||||.| .||| ...|.|..||| |..|.| | ... . |.|..|.. . ... . .. ... | || || . QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK-----------------GKVKHYRIRRNDDGKYYIDET-WRRKFPSL-ELVNHY SIIPLA . || QHNPLG |
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| Phosphatase | TNS1.AA | Subfamily.PTPDC1.PD | 72-148 | 30 | 1.1e-10 | 30.5 | In-house | 135-207 (229) | Show / Hide |
Range on Protein: 72-148 Range on HMM: 135-207/229 Sequence Identity: 30% (23 aa) AKVLEFGWPDLHTPALEKICSICKAMDTWLnadPHNVVVLHNKGNRGRIGVVIAAYMHYSNiSASADQALDRFAMKR . ||..| ...||.| | | .| | . . .| .|| ||.||.|. |.. .|..|.. || iyfynfglkDygvasleriLdivkvvdfal---eegkiavHCHAGlGRtGvliacylvyak-rltaeeaiklvrskr |
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| Phosphatase | TNS1.AA | PTPc_motif | 70-192 | 12 | 5e-06 | 19.24 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 70-192 Range on HMM: 1-92/92 Sequence Identity: 12% (16 aa) LHAKVLEFGWPDL-----HTPALEKICSICKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYMHYSNISASADQALDRFAMKRFYEDKIVPIGQPSQRR . . .||| ..| . | ...... .| | || |...|..| ... .. TVHHYHYTNWPDHVEKDSGVPE-DSILEFIRHVRK--------PIVVHCSAGCGRTGTFCAIDMMMQQ---------------------------VDIFQ YVHYFSGLLSGSIKMNNKPLFLHHVIMH .|... |..... .|....|. TVKEMRKQRPGMVQTEEQYIFCYRCILE |
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| PTB | TNS1.AA | PTB | 1594-1735 | 21 | 2.9e-31 | 111.12 | SMART | 1-155 (156) | Show / Hide |
Range on Protein: 1594-1735 Range on HMM: 1-155/156 Sequence Identity: 21% (35 aa) KQGAACNVLFVNSVDMESLT-------GPQAISKATSETLAADPTPAATIVHFKVSAQGITLTDNQRKLFFRRHYPLNTVTFCDLDPQERKWMKTEGG-- .|...||... .|.... . |.|.. .. .. ... . .|...| .|..|.|.|.| ....|.|.....|| ||. | | .| || PWGCCFNVWYLGCVEVPHHRNSMAPGKGMQVCQECMRKIR--QHWKHWQKMHLHISVDGVKLIDPQTK-QVIHHHPIHRISFCAHDPY-R-W-NT-GGHH --APAKLFGFVARKQGS------TTDNACHLFAELDPN---QPASAIVNFVSKVMLNAGQKR . ...||...|.... |. ..||.| ||. ...... .| .... . |.. CCDDDRCFGYICRHPNDRGSHRMTYWFRCHVFWCEDPHAEDIAQTIGQAFQVCYQQCQKQRC |
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| SH2 | TNS1.AA | SH2 | 1463-1557 | 26 | 4.1e-14 | 43.26 | Pfam | 1-81 (81) | Show / Hide |
Range on Protein: 1463-1557 Range on HMM: 1-81/81 Sequence Identity: 26% (26 aa) WYKPEISREQAIALLKD--QEPGAFIIRDSHSFRGAYGLAMKVSSPPPTIMQQNKKGDMTHELVRHFLIETGPRGVKLKGCPNEPNFGSLSALVYQH || . |||..| ||. ...|.|..|.| | | | | . .| . |.|. | . ..| .. .. |.||. ||. . WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP--------------GDRVKHYRIQRTDNG-GYYITGRHK-FCSLQELVEHY |
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| PTB | TNS1.AA | PTB | 1598-1734 | 36 | 5.9e-74 | 256.8 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 1598-1734 Range on HMM: 1-141/141 Sequence Identity: 36% (52 aa) ACNVLFVNSVDMESLTGPQAISK--ATSETLAADPTPAATIVHFKVSAQGITLTDNQRKLFFRRHYPLNTVTFCDLDPQERKWMKTEGGAPAKLFGFVAR ...|......||.|.||.|.... .......|.... .. .||.||.|.||||||..|.|||.|||||....|...|....|..|.....||.|.||.. QYHVEHLMTCDMDSRTGMQCVEDCIRKLQMMDAQGRVWTQDMHFQVSDQHITLTDNETKEFFREHYPLNSIRHCQAVPNDCRWNSTRDHDQAKIFAFVCQ KQGSTTDNACHLFA--ELDPNQPASAIVNFVSKVMLNAGQK .......|.||.|. |||..||...|..|..|.||...|. EPHQSKPNVCHFFQCDELDAEQPHEDIEKFIHKCMLGKKQR |
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