Gene TPTE
TPTE
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of TPTE.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | TPTE.AA | Subfamily.PTPDC1.PD | 237-377 | 25 | 1.5e-10 | 31.8 | In-house | 65-211 (229) | Show / Hide |
Range on Protein: 237-377 Range on HMM: 65-211/229 Sequence Identity: 25% (37 aa) LDLTYVTERIIAMSFPSSGR-------QSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVV---RIMIDDHNVPTLHQMVVFTKEVNEWM | |.||| |.|.. |||. . | . || |. .. | . | .||| .. .. . . ..|..|..|....| |. . lystwvtenilalarpsselldqykllekfkesGikavinLqeagehahCGagleesGfsYdpeelmrqgiyfynfglkDygvasleriLdivkvvdfal aqdLENIVAIHCKGGTDRTGTMVCAFLIASEICsTAKESLYYFGERRTDKT .| .|.|| | ||| .....|. .. ||.|.. ..|.. ---eegkiavHCHAGlGRtGvliacylvyakrl-taeeaiklvrskrpksi |
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| Phosphatase | TPTE.AA | Subfamily.TPIP.PD | 295-539 | 78 | 9.40000000001e-143 | 465.0 | In-house | 1-245 (245) | Show / Hide |
Range on Protein: 295-539 Range on HMM: 1-245/245 Sequence Identity: 78% (193 aa) FHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTHSEKFQGVETPSQKRYV |||||.||||||||||||...|||||||.||.|.||||.||||||||..||||.|||.||||||..||.|||.||||||||||||.||||||||||.||| fhnrvsrimiddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryv AYFAQVKHLYNWNLPPRRILFIKHFIIYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNITTDKILIDVFDGLPLYDDVKVQFFYSNLPTYYDNCSF .|.||||||||||||||||||||.|||||| | |||.|. ||||||||. |||.||.| .| ||||||.|.|| ||||||||||| |||| ||||| | gylaqvkhlynwnlpprrilfikrfiiysirgdvcdlkvqvvmekkvvfsstslgncsilhdietdkilinvydgpplyddvkvqffssnlpkyydncpf YFWLHTSFIENNRLYLPKNELDNLHKQKARRIYPSDFAVEILFGE .||. ||||.|||| ||.||||| ||||| .||| .||||||||| ffwfntsfiqnnrlclprneldnphkqkawkiyppefaveilfge |
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| Phosphatase | TPTE.AA | Family.DSP.PD | 261-541 | 28 | 2e-78 | 255.3 | In-house | 116-381 (387) | Show / Hide |
Range on Protein: 261-541 Range on HMM: 116-381/387 Sequence Identity: 28% (82 aa) RNPIKEVVRFLDKKHRNHYRVYNLCseraYDPKHFHN----RVVRIMIDDHNVPTLHQMvvFTKEVNeWMAQ--DLENIVAIHCKGGTDRTGTMVCAFLI . . . . |. .. .. ||. .|...|.. ...||.|||||.|.|... |.| .. .. . | .. |..|||.| |.||...|.|. | lgsllaaknlewlkelgvtkivnlt----ddkpqftkelgikylripidDhnapplenl--fekaid-fieegndskgvVlVHCkaGkgRsgtliiaYlm ASEICSTAkESLYYFGERRtdkthsekfQGVETPSQKryvaYFAQVKHLYNWNLPPRRILFIKHFIIYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVL | .. |.|... ..| .|| ||.|. ...|.|.|....|..........|.|.|| . ... .. ..|||... ..|.....| ksegltle-ealdwvrskR---------pgvitpnqg----flkqlkdlekeklkvssevmelrfvissivqnlgsvevsvsvlkkvatekakldrlkiL DNITTDKILIDVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNLHKQKARRIYPSDFAVEILFGEKM . ..|..| . |||||..||||..| .||. ..... . .. .|..|....| |.|.|||.|||.|. .|. .||||....|. videqekvvitikdglplsgDVkvelfkknldkiirdiilntfFvtnyikdeslvlvkkeldelhkskifdvykdseaveiseefki |
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| Phosphatase | TPTE.AA | Subfamily.PTEN.PD | 238-537 | 28 | 2.8e-48 | 155.7 | In-house | 1-303 (305) | Show / Hide |
Range on Protein: 238-537
Range on HMM: 1-303/305
Sequence Identity: 28% (85 aa)
DLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIH
|..|. .|..|.| . .... .......|. ..........|.... .. .|..|| . .|||| |||. . . ..|..|. .|.|.||.||
disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavH
CKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKThsekfQGVETPSQKRYVAYFAQvkhLYNWNLPPRRILFIKHFIIYSIPRYVRDLKIqIEM
| | |||.|.||.|. | |...|.|.| ...| || . .|| |||.||| || . | . ..| .. . |.| |..| . .|
CkaGkGRtGvmicayLlksgikksadealaiydekRtkdk-----kGVtiPSQrRYvqYfsk---lvkssvpyskvslnvceirfsesscvqnlgm-vec
EKKVVF-STISLGKCSVLDNITTD---KILIDVFDGLPLYDDVKVQFFYSNlPtyyDNCSFYFWLHTSFIENNR------------LYLPKNELDNLHKQ
|.. |. | | . | ... . .|. |||... . | |. .||| | |. || |.|.|..||. .. . .| . |.|
sisvlhdsatenakpdrlktlpidfqksfvltikpsipvsgdvkfeltkks-p---dkiichfwlntffvrnyspcesdgtvnkyihtlskseiddvhkd
KARRIYPSDFAVEILF
sehkrfseefkisivf
|
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| Phosphatase | TPTE.AA | PTEN_C2 | 409-539 | 32 | 2.2e-44 | 158.54 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 409-539 Range on HMM: 1-141/141 Sequence Identity: 32% (46 aa) PPRRILFIKHFII-YSIPRY----VR-DLKIQIEMEKKVVFSTISLGKCSVLDNI-TTDKILIDVFDGLPLYDDVKVQFFYSN-LP--TYYDNCSFYFWL ||...||....|. ..||. . ...||| .....|| ....|. ... ... ..... ..|...|||.|.. .. .. ..|..| |.||. PPPKPLFLHCIIMDHGIPNFKQGGGCWRPYIQIYQNDQKVF--YTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYEECMFRFWF HTSFIE--NNRLYLPKNELDNLHKQKARRIYPSDFAVEILFGE .|.||| ||||..||||||...|.|. ...|.||.||..| | NTCFIEHNNNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE |
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| Phosphatase | TPTE.AA | Subfamily.Tensin.PD | 295-537 | 26 | 1.5e-32 | 103.9 | In-house | 1-235 (237) | Show / Hide |
Range on Protein: 295-537 Range on HMM: 1-235/237 Sequence Identity: 26% (64 aa) FHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRtdkTHSEKFQGVETPSQKRYV ....|. . |. |.|... |... |. |..|.|..||||| |.| ...|.. |.|...|...| | .| .| .|| |||.||| lnekvldlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkr---fyddkvsgvtqPsqrryv AYFAQVkhLYNWNLPPRRILFIKHFIIYSIPRYVRDLKIQIEMEkkvVFSTISLGKCSVLDNIT---TDKILIDVFDGLPLYDDVKVQFFYSNLPTYYDN || .. | . . ||... |. .|| . . .. . .. ...| | . |.. |... | . .|| || |. .. .| . . eyfsgl--lsgsiklnssplflhyvilhgipnfdskggcrpflk---iyqalqlvytsgvynvagedterlcitiepalllkgdvlvkcyhkklrsttrd CSFYFWLHTSFIENNRLYLPKNELDNLHKQKArriYPSDFAVEILF | .||. |.. .| ..|..||. .|.. .|. ||..| vvfrvqfhtgaikdlklvfekedldealkder---fpeyakvelvf |
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| Phosphatase | TPTE.AA | Subfamily.DSP11.PD | 286-377 | 25 | 1.9e-14 | 44.6 | In-house | 31-126 (141) | Show / Hide |
Range on Protein: 286-377 Range on HMM: 31-126/141 Sequence Identity: 25% (24 aa) SERAYDPKHFHNRV---VRIMIDDHNVPTLHQMVVFTKEVNEWM--AQDLENIVAIHCKGGTDRTGTMVCAFLIASEICStAKESLYYFGERRTDKT .| |..|..... ..... |.|| ... |...|.|.. .| ......|| | .||| ..| .|| | | ..... | || . tdryykkkeltdegvkykklncpGhevpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegys-pedaieafeearGhsl |
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| Phosphatase | TPTE.AA | Subfamily.DSP23.PD | 299-366 | 32 | 7.4e-13 | 39.6 | In-house | 36-100 (128) | Show / Hide |
Range on Protein: 299-366 Range on HMM: 36-100/128 Sequence Identity: 32% (22 aa) VVRIMIDDHNVPTLHQMVVFTKEVNEwmAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICStAKESL ..|| |.|. |.|.|.. . . |.| |.. |. |..|| |. ||||.. .|...| . |.... lrridipdfcPPaleqvarlvrivee--aekkeeavgvhcalGlGrtGtllacylvkeegla-addai |
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| Phosphatase | TPTE.AA | Subfamily.RNGTT.PD | 286-375 | 24 | 7.2e-12 | 36.1 | In-house | 30-122 (140) | Show / Hide |
Range on Protein: 286-375 Range on HMM: 30-122/140 Sequence Identity: 24% (22 aa) SERAYDPKHFHNR---VVRIMIDDH-NVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTaKESLYYFGERRTD .| || ...... ... . . . || |. .| | |.|.. . ......|| | .||| ...|.|. | .| .... | .| tsryydkeelekegvkyiklqcrGrGeaPtkeqtklfiklvkeflkkkPdevigvhCthGfnrtGflivayLvekedwsv-eaavalfakarpp |
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| Phosphatase | TPTE.AA | Subfamily.CDC14.PD | 251-365 | 26 | 1.6e-08 | 25.4 | In-house | 135-231 (258) | Show / Hide |
Range on Protein: 251-365 Range on HMM: 135-231/258 Sequence Identity: 26% (31 aa) FPSSGRQSFYRNPIKEVVRfLDKKhrnhyrvynlcserAYDPKHFHNRVV---RIMIDDHNVPTLHQMVVFTKEVNEWmaqdlENIVAIHCKGGTDRTGT | . . | .| ....|| |.|| || |.| . . .. | ||. . . |.. ... | .|.||| | ||||. aPeklleyfrknnvttivr-Lnkk--------------lYdakkftdaGfahlDlffiDGtvPsdailkkfleiteka-----eGaiavhCkaGLGrtgt MVCAFLIASEiCSTAKES . ..|| ||.|. ligcylikhy-rftaaet |
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| Phosphatase | TPTE.AA | Subfamily.PTPMT1.PD | 302-384 | 18 | 1.4e-07 | 22.4 | In-house | 59-139 (146) | Show / Hide |
Range on Protein: 302-384 Range on HMM: 59-139/146 Sequence Identity: 18% (15 aa) IMIDDHNVPTLHQMVVFTKEVNEWmaQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTHSEKFQG ..| ..|.|... . ... ..... | .||| | | .|.| ..|. .. .|. . . |.. . .|.... atvDfteapslekleegvefiekv--askgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlkskqwra |
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| Phosphatase | TPTE.AA | Subfamily.DSP19.PD | 292-363 | 26 | 2.7e-07 | 21.5 | In-house | 43-111 (139) | Show / Hide |
Range on Protein: 292-363 Range on HMM: 43-111/139 Sequence Identity: 26% (19 aa) PKHFHNRVVRIMiDDHNVPTLHQMVVFTKEVNEwmAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAK ||.|. . |. |. .. |... .. ..| |.. ...| .||. | |. ..| |.|...| |. | pkdftyksieil-DlpetkllsylkealdFiee--arskdgrvlvHCnAGvSRsasvviaylmkdeelslek |
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| Phosphatase | TPTE.AA | Subfamily.PRL.PD | 269-375 | 19 | 2.9e-07 | 21.3 | In-house | 16-123 (140) | Show / Hide |
Range on Protein: 269-375 Range on HMM: 16-123/140 Sequence Identity: 19% (21 aa) RFLDKKHRNHYRVYNLCSERAYDPKHFHNR---VVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEIcsTAKES .|... .... . . | .|| ...... |. .. || .||. . . . . ..| ... ...||.|| | |. .|. || . .. .... kfieelkkenvkevvrvcepsydaeklkeegievldlafddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm--kyeda LYYFGERRTD . |.| . vefirekrrg |
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| Phosphatase | TPTE.AA | Subfamily.RB.PD | 302-351 | 28 | 5.6e-07 | 20.1 | In-house | 162-213 (261) | Show / Hide |
Range on Protein: 302-351 Range on HMM: 162-213/261 Sequence Identity: 28% (14 aa) IMIDDHNVPTL-HQMVVFTKEVNEWMAQD-LENIVAIHCKGGTDRTGTMVCA . ||.|| .... |...|.|.. .. .. . .|| | |||| . tsWpdhgvPektktlldfvrtvreaiekkaskkPivvHCsaGvGRtGtfial |
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| Phosphatase | TPTE.AA | Subfamily.N3.PD | 276-351 | 22 | 1.2e-06 | 18.8 | In-house | 139-213 (261) | Show / Hide |
Range on Protein: 276-351 Range on HMM: 139-213/261 Sequence Identity: 22% (16 aa) RNHYRVYNLCSERAYDPKHFHnRVVRIMIDDHNVPTL-HQMVVFTKEVNEWMAQDlENIVAIHCKGGTDRTGTMVCA .| |. ... . .. . .. . ||.||. .... |...|.. . . |. | .|| .| .||| .. syvlrelvlkdketkeerkil-qlqylaWpdhgvPddsadflefvervrklrsgk-eePvvvhCsaGigrtGvlill |
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| Phosphatase | TPTE.AA | Subfamily.RK.PD | 279-354 | 17 | 1.4e-06 | 18.6 | In-house | 144-221 (267) | Show / Hide |
Range on Protein: 279-354 Range on HMM: 144-221/267 Sequence Identity: 17% (14 aa) YRVYNLCS-ERAYDPKHFHNRVVRIMIDDH-NVPTLHQ-MVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVcAFLI |..... |... .. ... . .. .||. .. .. . ..|... ... | . .|| |. |.|| . | | vrifrveklargqeeirevrqfqflgWpeyrdvPvskrsllklirrvkksqeeeeeGrivvhClaGaGrsGtfi-aidi |
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| Phosphatase | TPTE.AA | Subfamily.N_Choan_1.PD | 302-351 | 30 | 1.8e-06 | 18.5 | In-house | 163-213 (262) | Show / Hide |
Range on Protein: 302-351 Range on HMM: 163-213/262 Sequence Identity: 30% (15 aa) IMIDDHNVPT-LHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCA . || ||. .... | |.|.. .. . . ||| | |||| . taWPdhGvPattkellefrkavlkatkkktkaplvihCsaGvGrtGtyial |
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| Phosphatase | TPTE.AA | Subfamily.DSP12.PD | 301-361 | 26 | 4.1e-06 | 17.9 | In-house | 52-111 (143) | Show / Hide |
Range on Protein: 301-361 Range on HMM: 52-111/143 Sequence Identity: 26% (16 aa) RIM-IDDHNVPTLHQMVVFTKEVNEWMaqDLENIVAIHCKGGTDRTGTMVCAFLIASEICST | .|. . . |. . .. ..| . . |. | .||. | | |.| |.|. .| .| liqilDepeedlLshldeavrFieegl--ekegavlvHClagvSRSvtiviAYlmkkeklsl |
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| Phosphatase | TPTE.AA | Subfamily.N13.PD | 303-354 | 28 | 5.1e-06 | 17.1 | In-house | 164-214 (259) | Show / Hide |
Range on Protein: 303-354 Range on HMM: 164-214/259 Sequence Identity: 28% (14 aa) MIDDHNVPT-LHQMVVFTKEVNEWMAqDlENIVAIHCKGGTDRTGTMVCAFLI ||.||. ..| | .||.. | . ...|| | |.|.... . kwPdhgvPssaaelvqfvaevrllqt-d-agPivvhcsaGiGrsGvlitidvv |
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| Phosphatase | TPTE.AA | Subfamily.R_Anemone_2.PD | 268-350 | 16 | 5.9e-06 | 16.9 | In-house | 129-213 (262) | Show / Hide |
Range on Protein: 268-350 Range on HMM: 129-213/262 Sequence Identity: 16% (14 aa) VRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVVR-IMIDDHNVPTL-HQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVC | .... ..| . .. .| ... . | . |..||. ... . ..|... .. ......|| .| |||. . velkeevelsdyvlrsfkvkrteeeeerqvrqfhytsWpdegvpesgaslldlvrqvekaqqesgagpivvhcsaGvGrtGvfia |
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| Phosphatase | TPTE.AA | Subfamily.N12.PD | 305-351 | 28 | 7.8e-06 | 16.1 | In-house | 173-219 (270) | Show / Hide |
Range on Protein: 305-351 Range on HMM: 173-219/270 Sequence Identity: 28% (13 aa) DDHNVPTLH-QMVVFTKEVNEWMAQDlENIVAIHCKGGTDRTGTMVCA ||.||. . ... ....|.| .. .. ...|| | ||||.. PDhgvPssaksllelielvrelqese-daPlvvhCsaGvGrtGtiiai |
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