Gene TPTE2
TPTE2
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of TPTE2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Ion_trans | TPTE2.AA | Ion_trans | 111-205 | 21 | 8e-06 | 23.93 | Pfam | 1-93 (199) | Show / Hide |
Range on Protein: 111-205 Range on HMM: 1-93/199 Sequence Identity: 21% (22 aa) ISLAIGLFFLMDVLLRVFVEG----RQQYFSDLFNILDTAIIVIPLLVDVIYIFFDIKLLRNIPRWTHLVRLLRLIILIR---IFHLLHQKRQ-LEKL-M . .. ..|... .|.... | .. || | .|..| ..||| ..|.|. ||.. ..| ||.. ..| .. |. . . . .| FDYVFTVWFTFEMILKFWAFGFKFHPFHYFRDWWNWFD-FFVVIPSYIDLIWFFFNWD----------WFRVLRVFRWLRVLRPLRLFRRWPGWMRTLWV RRLV . |. WMLM |
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| Phosphatase | TPTE2.AA | Subfamily.PTPDC1.PD | 219-361 | 26 | 4e-11 | 33.8 | In-house | 65-213 (229) | Show / Hide |
Range on Protein: 219-361 Range on HMM: 65-213/229 Sequence Identity: 26% (39 aa) LDLTYVTERIIAMSFPSSGR-------QSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNR---VSRIMIDDHNVPTLHEMVVFTKEVNEWM | |.||| |.|.. |||. . | . |. |. .. | . | .||| .. .. . . ..|..|..|....| |. . lystwvtenilalarpsselldqykllekfkesGikavinLqeagehahCGagleesGfsYdpeelmrqgiyfynfglkDygvasleriLdivkvvdfal aqdLENIVAIHCKGGKGRTGTMVCALLIASEIfLTAEESLYYFGERRTNKTHS .| .|.|| |.|||| .... |. .. |||||.. ..|.. .. ---eegkiavHCHAGlGRtGvliacylvyakr-ltaeeaiklvrskrpksiqt |
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| Phosphatase | TPTE2.AA | Subfamily.TPIP.PD | 277-521 | 95 | 1e-170 | 556.6 | In-house | 1-245 (245) | Show / Hide |
Range on Protein: 277-521 Range on HMM: 1-245/245 Sequence Identity: 95% (235 aa) FHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYV ||||||||||||||||||.|.|||||||.||.|.||||.||||||||||||||.||||||||||||||||||.|||||||.||||||||||||||||||| fhnrvsrimiddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryv GYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPF ||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| gylaqvkhlynwnlpprrilfikrfiiysirgdvcdlkvqvvmekkvvfsstslgncsilhdietdkilinvydgpplyddvkvqffssnlpkyydncpf FFWFNTSFIQNNRLCLPRNELDNPHKQKAWKIYPPEFAVEILFGE ||||||||||||||||||||||||||||||||||||||||||||| ffwfntsfiqnnrlclprneldnphkqkawkiyppefaveilfge |
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| Phosphatase | TPTE2.AA | Family.DSP.PD | 240-522 | 31 | 2.3e-97 | 317.7 | In-house | 113-380 (387) | Show / Hide |
Range on Protein: 240-522 Range on HMM: 113-380/387 Sequence Identity: 31% (91 aa) SFYRNPIEEVVRFLDKKHRNHYRVYNLCseraYDPKHFHN----RVSRIMIDDHNVPTLHEMvvFTKEVNeWMAQ--DLENIVAIHCKGGKGRTGTMVCA . | . . . . |. .. .. ||. .|...|.. .. ||.|||||.|.|... |.| .. .. . | .. |..|||.||||.||...| hlylgsllaaknlewlkelgvtkivnlt----ddkpqftkelgikylripidDhnapplenl--fekaid-fieegndskgvVlVHCkaGkgRsgtliia LLIASeIFLTAEESLYYFGERRtnkthsnkfQGVETPSQNryvgYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNC |. | ||.||.|... ..| .|| ||.|. ...|.|.|....|.........||.|.||........|.|...|||......|... Ylmks-egltleealdwvrskR---------pgvitpnqg----flkqlkdlekeklkvssevmelrfvissivqnlgsvevsvsvlkkvatekakldrl SILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQNNRLCLPRNELDNPHKQKAWKIYPPEFAVEILFGEK .||...|..|..|...||.||..||||..|..||.|..........|.|..|....|.|...|||..||.|....|....||||....| kiLvideqekvvitikdglplsgDVkvelfkknldkiirdiilntfFvtnyikdeslvlvkkeldelhkskifdvykdseaveiseefk |
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| Phosphatase | TPTE2.AA | Subfamily.PTEN.PD | 220-519 | 28 | 2.8e-50 | 162.3 | In-house | 1-303 (305) | Show / Hide |
Range on Protein: 220-519 Range on HMM: 1-303/305 Sequence Identity: 28% (87 aa) DLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIH |..|. .|..|.| . .... .......|. ..........|.... .. .|..||. . .|||| |||. . . ..|..|. .|.|.||.|| disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavH CKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKThsnkfQGVETPSQNRYVGYFAQvkhLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVM | ||||||.|.|| |. | |. .|.|.| ...| ||.. .|| ||| ||| || . | . ..| .. . |.| | .| . . CkaGkGRtGvmicayLlksgikksadealaiydekRtkdk-----kGVtiPSQrRYvqYfsk---lvkssvpyskvslnvceirfsesscvqnlgmvecs EKKVVFSSTSLGNCSILHDIET--DK-ILINVYDGPPLYDDVKVQFFSsnlpKYYDNCPFFFWFNTSFIQNNRLC------------LPRNELDNPHKQK . |.| . |. . .| ... . |. |||... | |. .||.|| |..| || ..|.|. ||. | . || . |. isvlhdsatenakpdrlktlpidfqksfvltikpsipvsgdvkfeltk----kspdkiichfwlntffvrnyspcesdgtvnkyihtlskseiddvhkds AWKIYPPEFAVEILF | ehkrfseefkisivf |
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| Phosphatase | TPTE2.AA | PTEN_C2 | 391-521 | 32 | 1.7e-47 | 168.91 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 391-521 Range on HMM: 1-141/141 Sequence Identity: 32% (46 aa) PPRRILFIKRFII-YSI----RGDVC-DLKVQVVMEKKVVFSSTSLGNCSILHDI-ETDKILINVYDGPPLYDDVKVQFFSSN-LP--KYYDNCPFFFWF ||...||....|. ..| |..| ....|.......|| .... . .... ... ... . . |...|||.|..... .. ..|..|.|.||| PPPKPLFLHCIIMDHGIPNFKQGGGCWRPYIQIYQNDQKVF--YTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYEECMFRFWF NTSFIQ--NNRLCLPRNELDNPHKQKAWKIYPPEFAVEILFGE ||.||. ||||..|.||||...|.|.||..||.|.||..| | NTCFIEHNNNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE |
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| Phosphatase | TPTE2.AA | Subfamily.Tensin.PD | 277-519 | 25 | 8.1e-27 | 85.1 | In-house | 1-235 (237) | Show / Hide |
Range on Protein: 277-519 Range on HMM: 1-235/237 Sequence Identity: 25% (62 aa) FHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRtnkTHSNKFQGVETPSQNRYV ....| . |. |.|. . |... |. |..|.|..||||||||.| ...| . |.| .|...| | .| .| .|| |||.||| lnekvldlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkr---fyddkvsgvtqPsqrryv GYFAQVKHlyNWNLPPRRILFIKRFIIYSIRG----DVCDLKVQVVMEKKVVFSStslgncsILHDI---ETDKILINVYDGPPLYDDVKVQFFSSNLPK || .. . . . ||.. |. .| .| ... ..|..| .. . .|... | .. | || |. . .| eyfsglls--gsiklnssplflhyvilhgipnfdskggcrpflkiyqalqlvyts-------gvynvagedterlcitiepalllkgdvlvkcyhkklrs YYDNCPFFFWFNTSFIQNNRLCLPRNELDNPHKQKAwkiYPPEFAVEILF . | | |. |.. .| .....||. .|.. .| ||..| ttrdvvfrvqfhtgaikdlklvfekedldealkder---fpeyakvelvf |
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| Phosphatase | TPTE2.AA | Subfamily.DSP11.PD | 268-358 | 25 | 1.4e-12 | 38.6 | In-house | 31-125 (141) | Show / Hide |
Range on Protein: 268-358 Range on HMM: 31-125/141 Sequence Identity: 25% (24 aa) SERAYDPKHFHNR---VSRIMIDDHNVPTLHEMVVFTKEVNEWM--AQDLENIVAIHCKGGKGRTGTMVCALLIASEIFlTAEESLYYFGERRTNK .| |..|..... .... |.|| ... |...|.|.. .| ......|| | ||| ..| || | . .|... | || . tdryykkkeltdegvkykklncpGhevpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegy-spedaieafeearGhs |
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| Phosphatase | TPTE2.AA | Subfamily.DSP23.PD | 281-354 | 32 | 1.9e-12 | 38.4 | In-house | 36-106 (128) | Show / Hide |
Range on Protein: 281-354 Range on HMM: 36-106/128 Sequence Identity: 32% (24 aa) VSRIMIDDHNVPTLHEMVVFTKEVNEwmAQDLENIVAIHCKGGKGRTGTMVCALLIASEIfLTAEESLYYFGER . || |.|. |.|. .. . . |.| |.. |. |..|| | |||||.. |...| |.|.... .| lrridipdfcPPaleqvarlvrivee--aekkeeavgvhcalGlGrtGtllacylvkeeg-laaddaiaevrkr |
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| Phosphatase | TPTE2.AA | Subfamily.RNGTT.PD | 268-357 | 22 | 9.4e-10 | 29.3 | In-house | 30-122 (140) | Show / Hide |
Range on Protein: 268-357 Range on HMM: 30-122/140 Sequence Identity: 22% (21 aa) SERAYDPKHFHNR---VSRIMIDDH-NVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFlTAEESLYYFGERRTN .| || ...... .. . . . || .. .| | |.|.. . ......|| | ||| ...| |. | . . |... | .| . tsryydkeelekegvkyiklqcrGrGeaPtkeqtklfiklvkeflkkkPdevigvhCthGfnrtGflivayLvekedw-sveaavalfakarpp |
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| Phosphatase | TPTE2.AA | Subfamily.CDC14.PD | 233-349 | 27 | 4.2e-09 | 27.4 | In-house | 135-233 (258) | Show / Hide |
Range on Protein: 233-349 Range on HMM: 135-233/258 Sequence Identity: 27% (33 aa) FPSSGRQSFYRNPIEEVVRfLDKKhrnhyrvynlcserAYDPKHFHNR---VSRIMIDDHNVPTLHEMVVFTKEVNEWmaqdlENIVAIHCKGGKGRTGT | . . | .| ....|| |.|| || |.| . . .. | ||. . . |.. ... | .|.||| | |||||. aPeklleyfrknnvttivr-Lnkk--------------lYdakkftdaGfahlDlffiDGtvPsdailkkfleiteka-----eGaiavhCkaGLGrtgt MVCALLIASEIFlTAEESLY . . || | ||.|.. ligcylikhyrf-taaetia |
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| Phosphatase | TPTE2.AA | Subfamily.PRL.PD | 250-362 | 22 | 1.7e-08 | 25.4 | In-house | 15-128 (140) | Show / Hide |
Range on Protein: 250-362 Range on HMM: 15-128/140 Sequence Identity: 22% (25 aa) VRFLDKKHRNHYRVYNLCSERAYDPKHFHN---RVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIasEIFLTAEE .|... .... . . | .|| ..... .| .. || .||. . . . . ..| ... ...||.|| | ||. .|. || |.. |... ekfieelkkenvkevvrvcepsydaeklkeegievldlafddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlvalali--eaGmkyed SLYYFGERRTNKTHSN . |.| . |. avefirekrrgainsk |
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| Phosphatase | TPTE2.AA | Subfamily.RB.PD | 255-333 | 22 | 6.5e-08 | 23.2 | In-house | 134-213 (261) | Show / Hide |
Range on Protein: 255-333 Range on HMM: 134-213/261 Sequence Identity: 22% (18 aa) KKHRNHYRVYNLCSERAYDpKHFHNRVSRIMIDDHNVPTL-HEMVVFTKEVNEWMAQD-LENIVAIHCKGGKGRTGTMVCA .|. ... . .. |. . |. ... . ||.|| . .. |...|.|.. .. .. . .|| | ||||| . ekeldewvirefkiekgke-krkvrqyhftsWpdhgvPektktlldfvrtvreaiekkaskkPivvHCsaGvGRtGtfial |
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| Phosphatase | TPTE2.AA | Subfamily.PTPMT1.PD | 287-365 | 20 | 9.8e-08 | 22.9 | In-house | 62-138 (146) | Show / Hide |
Range on Protein: 287-365 Range on HMM: 62-138/146 Sequence Identity: 20% (16 aa) DDHNVPTLHEMVVFTKEVNEwmAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFlTAEESLYYFGERR-TNKTHSNKFQ | ..|.|... . ... ..... | .||| |..| .|.| . |. .. . ..||. .. ..| . . .|.... Dfteapslekleegvefiek--vaskgssvYvHCkAGrtRsatlvacylmkkkkl-speeavkflkkkRpqirlkskqwr |
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| Phosphatase | TPTE2.AA | Subfamily.RK.PD | 261-340 | 19 | 1.2e-07 | 22.1 | In-house | 144-225 (267) | Show / Hide |
Range on Protein: 261-340 Range on HMM: 144-225/267 Sequence Identity: 19% (16 aa) YRVYNLCS-ERAYDPKHFHNRVSRIMIDDH-NVPTLH-EMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMvCALLIASEI |..... |... .. ... . .. .||. . .. . ..|... ... | . .|| | ||.|| .|. | |. vrifrveklargqeeirevrqfqflgWpeyrdvPvskrsllklirrvkksqeeeeeGrivvhClaGaGrsGtf-iaidivlem |
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| Phosphatase | TPTE2.AA | Subfamily.N_Choan_1.PD | 283-332 | 36 | 1.3e-07 | 22.3 | In-house | 162-212 (262) | Show / Hide |
Range on Protein: 283-332 Range on HMM: 162-212/262 Sequence Identity: 36% (18 aa) RIMIDDHNVP-TLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVC . || || | .|.. | |.|.. .. . . ||| | ||||| . ytaWPdhGvPattkellefrkavlkatkkktkaplvihCsaGvGrtGtyia |
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| Phosphatase | TPTE2.AA | Subfamily.N3.PD | 256-350 | 22 | 6.1e-07 | 19.9 | In-house | 137-228 (261) | Show / Hide |
Range on Protein: 256-350 Range on HMM: 137-228/261 Sequence Identity: 22% (21 aa) KHRNHYRVYNLCSERAYDPKHFHnRVSRIMIDDHNVPTL-HEMVVFTKEVNEWMAQDlENIVAIHCKGGKGRTGTMVCALLiASEiFLTAEESLYY .. .| |. ... . .. . .. . ||.||. .... |...|.. . . |. | .|| .| |||| .. . | . |.|..| tksyvlrelvlkdketkeerkil-qlqylaWpdhgvPddsadflefvervrklrsgk-eePvvvhCsaGigrtGvlillet-ala-lieaaepvyp |
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| Phosphatase | TPTE2.AA | Subfamily.N12.PD | 286-339 | 30 | 7.6e-07 | 19.5 | In-house | 172-224 (270) | Show / Hide |
Range on Protein: 286-339 Range on HMM: 172-224/270 Sequence Identity: 30% (16 aa) IDDHNVPTLHE-MVVFTKEVNEWMAQDlENIVAIHCKGGKGRTGTMvCALLIASE ||.||. .. .. ....|.| .. .. ...|| | |||||. .|. .. | WPDhgvPssaksllelielvrelqese-daPlvvhCsaGvGrtGti-iaidyvre |
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| Phosphatase | TPTE2.AA | Subfamily.N13.PD | 284-334 | 32 | 8.3e-07 | 19.7 | In-house | 163-212 (259) | Show / Hide |
Range on Protein: 284-334 Range on HMM: 163-212/259 Sequence Identity: 32% (16 aa) IMIDDHNVPT-LHEMVVFTKEVNEWMAqDlENIVAIHCKGGKGRTGTMVCAL . ||.||. |.| | .||.. | . ...|| | ||.|.... vkwPdhgvPssaaelvqfvaevrllqt-d-agPivvhcsaGiGrsGvlitid |
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| Phosphatase | TPTE2.AA | Subfamily.R_Anemone_2.PD | 285-333 | 24 | 1e-06 | 19.5 | In-house | 165-214 (262) | Show / Hide |
Range on Protein: 285-333 Range on HMM: 165-214/262 Sequence Identity: 24% (11 aa) MIDDHNVPTL-HEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCA |..||. ... . ..|... .. ......|| .| ||||. . sWpdegvpesgaslldlvrqvekaqqesgagpivvhcsaGvGrtGvfiav |
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| Phosphatase | TPTE2.AA | Subfamily.R_Sponge_2.PD | 249-359 | 19 | 2e-06 | 18.4 | In-house | 127-238 (262) | Show / Hide |
Range on Protein: 249-359 Range on HMM: 127-238/262 Sequence Identity: 19% (22 aa) VVRFLDKKHRNHYRV--YNLCSERAYDPKHFHNRVSRIMIDDHNVPTLH-EMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIflTAE .| . .......| . ..|..|.. . .. .. . .|.||. . .. . |.|.. .. .. . ..|. | ||||| .. . . . || kvtlkeeekladyiirklklskekssegeadvtqfhfvaWpehevPkdatsllelikrvlraqkksgnkaitvvCsdgvgrtGtfialdsvlerl--kae ESLYYFGERRTNKT |.. | .| .| eeidvfevlktlrt |
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| Phosphatase | TPTE2.AA | Subfamily.DSP19.PD | 297-348 | 27 | 5e-06 | 17.4 | In-house | 61-113 (139) | Show / Hide |
Range on Protein: 297-348 Range on HMM: 61-113/139 Sequence Identity: 27% (15 aa) MVVFTKEVNEWM--AQDLENIVAIHCKGGKGRTGTMVCALLIASEiFLTAEESL .. . ||. ... |.. ...| .||. | |. ..| | |...| |. |..| llsylkealdFieearskdgrvlvHCnAGvSRsasvviaylmkde-elslekal |
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| Phosphatase | TPTE2.AA | Subfamily.N5_RR.PD | 242-335 | 20 | 8.3e-06 | 16.3 | In-house | 123-219 (265) | Show / Hide |
Range on Protein: 242-335 Range on HMM: 123-219/265 Sequence Identity: 20% (19 aa) YRNPIEEVVRFLDKKHRNHYRVYNLCSERAYD-PKHFHNRVSRiMIDDHNVPT-LHEMVVFTKEVNEWMAQDLEN--IVAIHCKGGKGRTGTMVCALL . .. ... ....||.|.| .| . . . ... . ||..| .... . .||.| .. .. | .|| | ||||...... serygdveikveeiverndysvrklvlkylerversvkhywyt-dWPdhksPddintlldlvleveesreeenaklaPvvvhcsaGiGrtGcfiaisi |
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| Phosphatase | TPTE2.AA | Subfamily.RA.PD | 295-351 | 29 | 9e-06 | 16.2 | In-house | 180-234 (266) | Show / Hide |
Range on Protein: 295-351 Range on HMM: 180-234/266 Sequence Identity: 29% (16 aa) HEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEifLTAEESLYYF |. . |.|.. | .. ...|| | |||||.. . . ||. | | kGmlkllkkvkklqqqsanhpivvhcsaGvGrtGtfivldavler--vkaerkldvf |
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