Gene MTMR2
MTMR2
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of MTMR2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| GRAM | MTMR2.AA | GRAM | 71-139 | 22 | 2.1e-15 | 58.41 | SMART | 1-80 (80) | Show / Hide |
Range on Protein: 71-139 Range on HMM: 1-80/80 Sequence Identity: 22% (18 aa) AEM-EEPPLLPGENIKDM-AKDVTYICPFTG----AVRGTLTVTNYRLYFKS-MERDPPF----VLDASLGVINRVEKIG .. .. .|.|.|..... .|.||| |.. . | |.. ..|....|.| |.... . ... ...| |.||.. EKFRQHFKLPPNEKLINDCKKEVTYSCYLWRTYDIPVQGHMYISNNHICFCSNMFGWMTCPQYYKVVIPWADITRIEKMT |
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| Myotub-related | MTMR2.AA | Myotub-related | 234-351 | 62 | 4.7e-78 | 270.42 | Pfam | 1-121 (121) | Show / Hide |
Range on Protein: 234-351 Range on HMM: 1-121/121 Sequence Identity: 62% (76 aa) YELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNA---QSHKIFIFDARPSVNAVAN ||.|.||||.||||. | |.|||.||.|||.||.|||.|.|.|..|.|.|||||.||..|.|.|||||..||||..|| ||.|..|.||||..||.|| YEICPTYPAKLVVPKSISDDELKKVAKFRSWGRFPVLCWRHQENGAVICRCSQPLVGWWGWRCKEDEKLVQAIMKANADMIQSRKMYIVDARPYTNAMAN KAKGGGYESEDAYQNAELVFL .|||||||.|..|.|.|.||. RAKGGGYENEEHYPNWEFVFM |
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| GRAM | MTMR2.AA | GRAM | 75-139 | 26 | 7.7e-16 | 59.67 | Pfam | 9-78 (78) | Show / Hide |
Range on Protein: 75-139 Range on HMM: 9-78/78 Sequence Identity: 26% (19 aa) EPPLLPGENIKDMAKDVTYICPFTGA-----VRGTLTVTNYRLYFKSMERDPPF--VLDASLGVINRVEKIG . ||.|.|.. .... |||.|.. .. | |....||....|.|. .... .... ...| ||||.. D-PLPPNEKLIMDCN-VTYSCCLWRPFTKIPVQGRMYITNHHVCFYSDKFGWETYYKMVIPWNDITRVEKMQ |
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| Phosphatase | MTMR2.AA | Subfamily.MTMR1.PD | 365-513 | 87 | 2.4e-93 | 299.3 | In-house | 1-149 (149) | Show / Hide |
Range on Protein: 365-513 Range on HMM: 1-149/149 Sequence Identity: 87% (130 aa) KLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRV ||||||||.|.|..|||.||.|.||||||||||||.|||||||| ||||||||||||||||||||||||.||.|||||.|||||.|||||||||.|. |. klkeivypsideskwlsaleetkwlehiklilagavriadkvesektsvvvhcsdgwdrtaqltslamllldsyyrtikgfevliekewlsfghkfaeri GHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLY |||||||||||||||||||||||||.||||||||||||.|||||||||| ghgdknhadadrspvflqfidcvwqvtrqfptafefneeflitildhly |
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| Phosphatase | MTMR2.AA | Family.Myotubularin.PD | 374-513 | 75 | 2.1e-74 | 237.5 | In-house | 2-141 (141) | Show / Hide |
Range on Protein: 374-513 Range on HMM: 2-141/141 Sequence Identity: 75% (105 aa) IEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHAD .||..|||.||||.|||||||.|..| .|..|||. ||||.|||||||||||||||||.|.|| |||||.|||||.|||||||||.|. |.|||||.... aeekkwlselestkWlehiklllkaavkivekvekektsvlvhcsdGWdrtaqltslaqllldpyyrtieGfevliekeWlsfGhkfaerlghgdksese ADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLY ..||||||||||||.|.|.|||||||||| |||.|||||| eersPvflqfidcvyqltkqfptafefnesflikildhly |
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| Phosphatase | MTMR2.AA | Subfamily.C2-MTMR1.PD | 376-511 | 55 | 5.2e-60 | 191.1 | In-house | 3-135 (137) | Show / Hide |
Range on Protein: 376-511 Range on HMM: 3-135/137 Sequence Identity: 55% (75 aa) ETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDknhADAD . .|||.||||.|| .|| .| .| || ||| | .||||||||||.||..|| |.|| ||||| |. ||.|||||.|||.|. ||. | . ..| dvqwlsqlestqwlayikavlkaaraiarkveklavsalvhcsdgwdrtsqlvllaqllldpyyrtidglivliekewlafghkfderlggad---svse RSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDH ||.||||.||..|.|.|||.|||.. .|. . |. rspiflqfldclyqvtkqfpsafeytarlllklady |
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| Phosphatase | MTMR2.AA | Subfamily.MTMR3.PD | 379-513 | 53 | 5.2e-58 | 184.4 | In-house | 1-135 (135) | Show / Hide |
Range on Protein: 379-513 Range on HMM: 1-135/135 Sequence Identity: 53% (72 aa) WLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSP .||.||.|.||.|. .| |..... |. . |.||||||||||.|...|| |.|| ||||..||.||||.|||.|||.| |.|||.... .|.| flsalektkwlqhlsvllkaavkvvnavdkegrpvlvhcsdgwdrtpqivalakllldpyyrtlegfkvlverewldfghkfadrcghgedsddlnercp VFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLY ||||..|||.|...||||.||||| ||. ...| | vflqwldcvhqlkkqfptsfefneaflvklvqhty |
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| Phosphatase | MTMR2.AA | Subfamily.R_Nematode_3.PD | 397-430 | 54 | 9e-09 | 24.3 | In-house | 185-218 (267) | Show / Hide |
Range on Protein: 397-430 Range on HMM: 185-218/267 Sequence Identity: 54% (17 aa) AGALRIADKVESGKTSVVVHCSDGWDRTAQLTSL || ....||. ||.|||||||| |.| | . kealelikfveksktpvvVHCsdGisRsatlaai |
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| Phosphatase | MTMR2.AA | PTPc_motif | 365-513 | 12 | 1.1e-08 | 36.08 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 365-513
Range on HMM: 1-92/92
Sequence Identity: 12% (19 aa)
KLKEIVYPNIEET-----HWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHR
... |.| . . . ....|.. ..|||||.|..||... .. |.| .
TVHHYHYTNWPDHVEKDSGVPE-DSILEFIRHVRK-----------------PIVVHCSAGCGRTGTFCAIDMMMQQ-----------------------
FQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLY
. . ..|..| | | ... .| .. . .|.
---------------------VDIFQTVKEMRKQRPGMVQTEEQYIFCYRCILE
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