MTMR2
Species: Human
Alias: CMT4B, KIAA1073, MTMR2, CMT4B1
External Links: COSMIC , Entrez Gene
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: Myotubularin
Subfamily: MTMR1
Protein domain

Protein domains of MTMR2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
GRAM MTMR2.AA GRAM 71-139 22 2.1e-15 58.41 SMART 1-80 (80) Show / Hide
Range on Protein: 71-139
Range on HMM: 1-80/80
Sequence Identity: 22% (18 aa)

AEM-EEPPLLPGENIKDM-AKDVTYICPFTG----AVRGTLTVTNYRLYFKS-MERDPPF----VLDASLGVINRVEKIG
 .. .. .|.|.|..... .|.||| |.. .     | |.. ..|....|.| |.... .    ...  ...| |.||..
EKFRQHFKLPPNEKLINDCKKEVTYSCYLWRTYDIPVQGHMYISNNHICFCSNMFGWMTCPQYYKVVIPWADITRIEKMT

MTMR2.AA Myotub-related 234-351 62 4.7e-78 270.42 Pfam 1-121 (121) Show / Hide
Range on Protein: 234-351
Range on HMM: 1-121/121
Sequence Identity: 62% (76 aa)

YELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNA---QSHKIFIFDARPSVNAVAN
||.|.||||.||||. | |.|||.||.|||.||.|||.|.|.|..|.|.|||||.||..|.|.|||||..||||..||   ||.|..|.||||..||.||
YEICPTYPAKLVVPKSISDDELKKVAKFRSWGRFPVLCWRHQENGAVICRCSQPLVGWWGWRCKEDEKLVQAIMKANADMIQSRKMYIVDARPYTNAMAN

KAKGGGYESEDAYQNAELVFL
.|||||||.|..|.|.|.||.
RAKGGGYENEEHYPNWEFVFM

GRAM MTMR2.AA GRAM 75-139 26 7.7e-16 59.67 Pfam 9-78 (78) Show / Hide
Range on Protein: 75-139
Range on HMM: 9-78/78
Sequence Identity: 26% (19 aa)

EPPLLPGENIKDMAKDVTYICPFTGA-----VRGTLTVTNYRLYFKSMERDPPF--VLDASLGVINRVEKIG
. ||.|.|.. .... |||.|.. ..     | |....||....|.|.  ....  .... ...| ||||..
D-PLPPNEKLIMDCN-VTYSCCLWRPFTKIPVQGRMYITNHHVCFYSDKFGWETYYKMVIPWNDITRVEKMQ

Phosphatase MTMR2.AA Subfamily.MTMR1.PD 365-513 87 2.4e-93 299.3 In-house 1-149 (149) Show / Hide
Range on Protein: 365-513
Range on HMM: 1-149/149
Sequence Identity: 87% (130 aa)

KLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRV
||||||||.|.|..|||.||.|.||||||||||||.|||||||| ||||||||||||||||||||||||.||.|||||.|||||.|||||||||.|. |.
klkeivypsideskwlsaleetkwlehiklilagavriadkvesektsvvvhcsdgwdrtaqltslamllldsyyrtikgfevliekewlsfghkfaeri

GHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLY
|||||||||||||||||||||||||.||||||||||||.||||||||||
ghgdknhadadrspvflqfidcvwqvtrqfptafefneeflitildhly

Phosphatase MTMR2.AA Family.Myotubularin.PD 374-513 75 2.1e-74 237.5 In-house 2-141 (141) Show / Hide
Range on Protein: 374-513
Range on HMM: 2-141/141
Sequence Identity: 75% (105 aa)

IEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHAD
.||..|||.||||.|||||||.|..| .|..|||. ||||.|||||||||||||||||.|.|| |||||.|||||.|||||||||.|. |.|||||....
aeekkwlselestkWlehiklllkaavkivekvekektsvlvhcsdGWdrtaqltslaqllldpyyrtieGfevliekeWlsfGhkfaerlghgdksese

ADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLY
..||||||||||||.|.|.|||||||||| |||.||||||
eersPvflqfidcvyqltkqfptafefnesflikildhly

Phosphatase MTMR2.AA Subfamily.C2-MTMR1.PD 376-511 55 5.2e-60 191.1 In-house 3-135 (137) Show / Hide
Range on Protein: 376-511
Range on HMM: 3-135/137
Sequence Identity: 55% (75 aa)

ETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDknhADAD
. .|||.||||.|| .|| .| .|  || |||    | .||||||||||.||..|| |.|| ||||| |. ||.|||||.|||.|. ||. |   . ..|
dvqwlsqlestqwlayikavlkaaraiarkveklavsalvhcsdgwdrtsqlvllaqllldpyyrtidglivliekewlafghkfderlggad---svse

RSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDH
||.||||.||..|.|.|||.|||..  .|. . |. 
rspiflqfldclyqvtkqfpsafeytarlllklady

Phosphatase MTMR2.AA Subfamily.MTMR3.PD 379-513 53 5.2e-58 184.4 In-house 1-135 (135) Show / Hide
Range on Protein: 379-513
Range on HMM: 1-135/135
Sequence Identity: 53% (72 aa)

WLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSP
.||.||.|.||.|.  .|  |..... |.  .  |.||||||||||.|...|| |.|| ||||..||.||||.|||.|||.|  |.|||....   .|.|
flsalektkwlqhlsvllkaavkvvnavdkegrpvlvhcsdgwdrtpqivalakllldpyyrtlegfkvlverewldfghkfadrcghgedsddlnercp

VFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLY
||||..|||.|...||||.||||| ||. ...| |
vflqwldcvhqlkkqfptsfefneaflvklvqhty

Phosphatase MTMR2.AA Subfamily.R_Nematode_3.PD 397-430 54 9e-09 24.3 In-house 185-218 (267) Show / Hide
Range on Protein: 397-430
Range on HMM: 185-218/267
Sequence Identity: 54% (17 aa)

AGALRIADKVESGKTSVVVHCSDGWDRTAQLTSL
|| ....||. ||.||||||||  |.| | .   
kealelikfveksktpvvVHCsdGisRsatlaai

Phosphatase MTMR2.AA PTPc_motif 365-513 12 1.1e-08 36.08 SMART 1-92 (92) Show / Hide
Range on Protein: 365-513
Range on HMM: 1-92/92
Sequence Identity: 12% (19 aa)

KLKEIVYPNIEET-----HWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHR
...   |.|  .      .  .     ....|..                  ..|||||.|..||... .. |.| .                       
TVHHYHYTNWPDHVEKDSGVPE-DSILEFIRHVRK-----------------PIVVHCSAGCGRTGTFCAIDMMMQQ-----------------------

FQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLY
                     . . ..|..|  | | ... .| ..  .  .|.
---------------------VDIFQTVKEMRKQRPGMVQTEEQYIFCYRCILE

Sequence
Name Sequence Type Origin Length Description Download
MTMR2.AA Protein None 643 None Fasta, JSON
MTMR2.NA RNA None 1929 None Fasta, JSON
MTMR2.AA.PD_365-513 Protein Phosphatase Domain None 149 None Fasta, JSON