Gene MTM1
MTM1
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of MTM1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| GRAM | MTM1.AA | GRAM | 29-97 | 28 | 8.6e-20 | 73.78 | Pfam | 1-78 (78) | Show / Hide |
Range on Protein: 29-97 Range on HMM: 1-78/78 Sequence Identity: 28% (22 aa) RDLTEAVP--RLPGETLITDKEVIYICPFNG-----PIKGRVYITNYRLYLRS-LETDSS-LILDVPLGVISRIEKMG ..... . .|.| ||.|..|.|.|.... | .||.||||.... .| .. ... ...|...|.|.|||. EKFRKHFKDPLPPNEKLIMDCNVTYSCCLWRPFTKIPVQGRMYITNHHVCFYSDKFGWETYYKMVIPWNDITRVEKMQ |
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| Myotub-related | MTM1.AA | Myotub-related | 192-309 | 55 | 4.7e-73 | 253.8 | Pfam | 1-121 (121) | Show / Hide |
Range on Protein: 192-309 Range on HMM: 1-121/121 Sequence Identity: 55% (67 aa) YELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVIRETNK---QISKLTIYDARPSVNAVAN ||.|.||||.|||| .|||.|..||.|||..|.|||.|.|.||..||.||||||||..|.|.|.|||.. |...|. | |..|.||||..||.|| YEICPTYPAKLVVPKSISDDELKKVAKFRSWGRFPVLCWRHQENGAVICRCSQPLVGWWGWRCKEDEKLVQAIMKANADMIQSRKMYIVDARPYTNAMAN KATGGGYESDDAYHNAELFFL .|.|||||....| |.|..|. RAKGGGYENEEHYPNWEFVFM |
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| GRAM | MTM1.AA | GRAM | 29-97 | 28 | 3.5e-19 | 70.97 | SMART | 1-80 (80) | Show / Hide |
Range on Protein: 29-97 Range on HMM: 1-80/80 Sequence Identity: 28% (23 aa) RDLTEAVPRLPGETLITD--KEVIYICPFNG----PIKGRVYITNYRLYLRS-LETDSSL----ILDVPLGVISRIEKMG ... . . .|.|.||.| |||.| |.... |. |..||.|.... .| .. ... ...|...|.|||||. EKFRQHFKLPPNEKLINDCKKEVTYSCYLWRTYDIPVQGHMYISNNHICFCSNMFGWMTCPQYYKVVIPWADITRIEKMT |
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| Phosphatase | MTM1.AA | Subfamily.MTMR1.PD | 323-471 | 77 | 1.4e-90 | 290.8 | In-house | 1-149 (149) | Show / Hide |
Range on Protein: 323-471 Range on HMM: 1-149/149 Sequence Identity: 77% (115 aa) KVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRI |.|.||||...||.|||.||.|.|||||||.|.||...||||.| |.||.|||||||||||||||||||.|||.||.|.|||.|..|||.|||||||.|| klkeivypsideskwlsaleetkwlehiklilagavriadkvesektsvvvhcsdgwdrtaqltslamllldsyyrtikgfevliekewlsfghkfaeri GHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLY |||||||.||||||.||||||||||...||||||||||.|||.|||||| ghgdknhadadrspvflqfidcvwqvtrqfptafefneeflitildhly |
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| Phosphatase | MTM1.AA | Family.Myotubularin.PD | 332-471 | 71 | 1.2e-72 | 232.2 | In-house | 2-141 (141) | Show / Hide |
Range on Protein: 332-471 Range on HMM: 2-141/141 Sequence Identity: 71% (100 aa) VEESHWLSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNHTD .||..|||.||||.|||||||.|..|.....||.. |.||||||||||||||||||||.|.||..||.|||||.|..|||.|||||||.|.|||||.... aeekkwlselestkWlehiklllkaavkivekvekektsvlvhcsdGWdrtaqltslaqllldpyyrtieGfevliekeWlsfGhkfaerlghgdksese ADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLY ..|||.||||||||.|..|||||||||||.||| |||||| eersPvflqfidcvyqltkqfptafefnesflikildhly |
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| Phosphatase | MTM1.AA | Subfamily.C2-MTMR1.PD | 334-469 | 53 | 2.4e-58 | 186.2 | In-house | 3-135 (137) | Show / Hide |
Range on Protein: 334-469 Range on HMM: 3-135/137 Sequence Identity: 53% (72 aa) ESHWLSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDknhTDAD . .||| ||||.|| .|| ||..| .| || | |||||||||||.||..|| |.|| .||.|.|. .|..|||..||||| ||. | . ..| dvqwlsqlestqwlayikavlkaaraiarkveklavsalvhcsdgwdrtsqlvllaqllldpyyrtidglivliekewlafghkfderlggad---svse RSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDH |||||||.||..|..||||.|||.. ..|. . |. rspiflqfldclyqvtkqfpsafeytarlllklady |
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| Phosphatase | MTM1.AA | Subfamily.MTMR3.PD | 337-471 | 53 | 1.5e-57 | 183.4 | In-house | 1-135 (135) | Show / Hide |
Range on Protein: 337-471 Range on HMM: 1-135/135 Sequence Identity: 53% (72 aa) WLSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNHTDADRSP .||.||.|.||.|. .| |..|.. | . ||||||||||||.|...|| |.|| .||..|||..||..||..|||||| | |||.... .|.| flsalektkwlqhlsvllkaavkvvnavdkegrpvlvhcsdgwdrtpqivalakllldpyyrtlegfkvlverewldfghkfadrcghgedsddlnercp IFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLY .|||..|||.|..|||||.|||||.||. ...| | vflqwldcvhqlkkqfptsfefneaflvklvqhty |
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| Phosphatase | MTM1.AA | PTPc_motif | 323-471 | 13 | 2.7e-12 | 48.08 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 323-471
Range on HMM: 1-92/92
Sequence Identity: 13% (21 aa)
KVKDIVYPNVEES-----HWLSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHK
.|. |.| . . . ....|.. ...||||.|..||... .. |.| .
TVHHYHYTNWPDHVEKDSGVPE-DSILEFIRHVRK-----------------PIVVHCSAGCGRTGTFCAIDMMMQQ-----------------------
FASRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLY
. . ..|..| || | ... .||.. .. .|.
---------------------VDIFQTVKEMRKQRPGMVQTEEQYIFCYRCILE
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| Phosphatase | MTM1.AA | Subfamily.R_Nematode_3.PD | 356-388 | 41 | 2.3e-07 | 20.2 | In-house | 186-218 (267) | Show / Hide |
Range on Protein: 356-388 Range on HMM: 186-218/267 Sequence Identity: 41% (13 aa) GAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSL |......| . |..|.|||||| |.| | . ealelikfveksktpvvVHCsdGisRsatlaai |
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| Phosphatase | MTM1.AA | Subfamily.DSP1.PD | 348-410 | 35 | 1.6e-06 | 18.1 | In-house | 59-120 (139) | Show / Hide |
Range on Protein: 348-410 Range on HMM: 59-120/139 Sequence Identity: 35% (22 aa) EHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLtSLAMLMLDSFYRSIEGFEILVQKE . |. .. ||. |.| . . ||||| | |.| . || || . .| | || . |. adisslfeeaidfidsvkkkgGrvlvhCqaGisrsati-vlayLmkekkvrleeafefvkqrr |
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| Phosphatase | MTM1.AA | Subfamily.DSP6.PD | 336-408 | 26 | 3e-06 | 16.8 | In-house | 49-120 (141) | Show / Hide |
Range on Protein: 336-408 Range on HMM: 49-120/141 Sequence Identity: 26% (19 aa) HWLSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTsLAMLMLDSFYRSIEGFEILVQ ... . |. . . . ||. |. | ||.||||| | |. .| || || . . .... . kykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvt-laylmkklalslndaydlvkk |
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