MTMR14
Species: Human
Alias: MTMR14, FLJ22405, FLJ46453, HJUMPY, FLJ90311, hEDTP, C3orf29
External Links: COSMIC , Entrez Gene
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: Myotubularin
Subfamily: MTMR14
Protein domain

Protein domains of MTMR14.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase MTMR14.AA Subfamily.MTMR3.PD 312-388 35 1.7e-09 26.8 In-house 19-91 (135) Show / Hide
Range on Protein: 312-388
Range on HMM: 19-91/135
Sequence Identity: 35% (28 aa)

KLLLSLVNS--DDDSGLLVHCISGWDRTPLFISLLRLSLwaDGLiHTSLKPTEILyltVAYDWFLFGHMLVDRLSKGEE
|  . .||.   ..  .||||  ||||||  ..| .| |  |   . .|.  ..|   |  .|. ||| . ||  .||.
kaavkvvnavdkegrpvlvhcsdgwdrtpqivalaklll--dpy-yrtlegfkvl---verewldfghkfadrcghged

Phosphatase MTMR14.AA Family.Myotubularin.PD 322-388 34 2e-10 29.6 In-house 37-97 (141) Show / Hide
Range on Protein: 322-388
Range on HMM: 37-97/141
Sequence Identity: 34% (23 aa)

DDSGLLVHCISGWDRTPLFISLLRLslWADGLIHTsLKPTEILyltVAYDWFLFGHMLVDRLSKGEE
. . .||||. |||||.   || .|   .|    | ..  |.|   .  .|. |||.. .|| .|..
ektsvlvhcsdGWdrtaqltslaql--lldpyyrt-ieGfevl---iekeWlsfGhkfaerlghgdk

Phosphatase MTMR14.AA Subfamily.MTMR1.PD 323-388 33 7.9e-08 21.3 In-house 46-105 (149) Show / Hide
Range on Protein: 323-388
Range on HMM: 46-105/149
Sequence Identity: 33% (22 aa)

DSGLLVHCISGWDRTPLFISLLRLSLwaDGLiHTSLKPTEILyltVAYDWFLFGHMLVDRLSKGEE
. ..|||  |||||. . ||  | |  |.  . ..|  |.|   .  .|  ||| . .|. .|.. 
ktsvvvhcsdgwdrtaqltslamlll--dsy-yrtikgfevl---iekewlsfghkfaerighgdk

Phosphatase MTMR14.AA Subfamily.C2-MTMR1.PD 326-386 33 2.9e-07 19.8 In-house 40-94 (137) Show / Hide
Range on Protein: 326-386
Range on HMM: 40-94/137
Sequence Identity: 33% (20 aa)

LLVHCISGWDRTPLFISLLRLSLwaDglihTSLKPTEILYLTVAYDWFLFGHMLVDRLSKG
||||  |||||  ...| .| |  |       .  . | . .  .|. ||| . .|| .  
alvhcsdgwdrtsqlvllaqlll--d----pyyrtidglivliekewlafghkfderlgga

Sequence
Name Sequence Type Origin Length Description Download
MTMR14.AA Protein None 650 None Fasta, JSON
MTMR14.NA RNA None 1950 None Fasta, JSON