Gene MTMR3
MTMR3
Species: Human
Alias: FLJ32333, FYVE-DSP1, ZFYVE10, MTMR3, KIAA0371
External Links:
COSMIC
,
Entrez Gene
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of MTMR3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Myotub-related | MTMR3.AA | Myotub-related | 185-347 | 43 | 1.1e-75 | 262.56 | Pfam | 1-121 (121) | Show / Hide |
Range on Protein: 185-347
Range on HMM: 1-121/121
Sequence Identity: 43% (71 aa)
YKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNG
|..| .||..|.||..|.|.||. |..||||.|.|....|||.|||||.||.||.|.|||||...||.|||...||.| |
YEICPTYPAKLVVPKSISDDELKKVAKFRSWGRFPVLCWRHQENGAVICRCSQPLVGWWGWRCKEDEKLVQAIMKANA-D--------------------
GDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFM
.||..|..|.|||.|..|.||||||||.|. |.|||.|.|||
---------------------MIQSRKMYIVDARPYTNAMANRAKGGGYENEEHYPNWEFVFM
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| Phosphatase | MTMR3.AA | PTPc_motif | 360-509 | 11 | 1e-06 | 25.06 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 360-509
Range on HMM: 1-92/92
Sequence Identity: 11% (17 aa)
QSLRLLCTQMPDP----GNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHK
. .. .|. || . . ....|. |..||||.|..|| ...|. .. .
TVHHYHYTNWPDHVEKDSGVPE-DSILEFIRHVRK-----------------PIVVHCSAGCGRTGTFCAIDMMMQQ-----------------------
FADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTY
. ...|... | | ... .| .. . .
---------------------VDIFQTVKEMRKQRPGMVQTEEQYIFCYRCILE
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| Phosphatase | MTMR3.AA | Subfamily.MTMR3.PD | 375-509 | 87 | 6e-85 | 272.4 | In-house | 1-135 (135) | Show / Hide |
Range on Protein: 375-509 Range on HMM: 1-135/135 Sequence Identity: 87% (118 aa) WLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCP .|||||.||||.|||||||.|. ||.|||...|||||||||||||||||||||||||||||||.|||.||||.|||||||||||||||||.||||||||| flsalektkwlqhlsvllkaavkvvnavdkegrpvlvhcsdgwdrtpqivalakllldpyyrtlegfkvlverewldfghkfadrcghgedsddlnercp VFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTY ||||||||||||..|||.||||||||||||||||| vflqwldcvhqlkkqfptsfefneaflvklvqhty |
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| Phosphatase | MTMR3.AA | Family.Myotubularin.PD | 371-509 | 62 | 2e-70 | 225.4 | In-house | 3-141 (141) | Show / Hide |
Range on Protein: 371-509 Range on HMM: 3-141/141 Sequence Identity: 62% (87 aa) DPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLN . .|||.|||||||.|...|||.| .|..|......||||||||||||.|...||.|||||||||||||.||.| |||.||||||.|.|||..|.. . eekkwlselestkWlehiklllkaavkivekvekektsvlvhcsdGWdrtaqltslaqllldpyyrtieGfevliekeWlsfGhkfaerlghgdksesee ERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTY ||.|||||..|||.||..|||..|||||.||.|...|.| ersPvflqfidcvyqltkqfptafefnesflikildhly |
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| Phosphatase | MTMR3.AA | Subfamily.MTMR1.PD | 371-509 | 56 | 1.5e-59 | 190.4 | In-house | 11-149 (149) | Show / Hide |
Range on Protein: 371-509 Range on HMM: 11-149/149 Sequence Identity: 56% (79 aa) DPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLN | .||||||.||||.|. ..|. |. ....|.. . |.||||||||||.|. .|| ||||.|||||.||.||.| ||| ||||||.| |||.. . deskwlsaleetkwlehiklilagavriadkvesektsvvvhcsdgwdrtaqltslamllldsyyrtikgfevliekewlsfghkfaerighgdknhada ERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTY .| |||||..||| |..||||..||||| ||. ...| | drspvflqfidcvwqvtrqfptafefneeflitildhly |
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| Phosphatase | MTMR3.AA | Subfamily.C2-MTMR1.PD | 374-508 | 51 | 2e-53 | 170.5 | In-house | 5-136 (137) | Show / Hide |
Range on Protein: 374-508 Range on HMM: 5-136/137 Sequence Identity: 51% (70 aa) NWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENsddLNERC .||| ||||.|| ... .||.| . |.. ||||||||||| |.|.||.||||||||||.|..||.| ||| ||||| .| |. . || qwlsqlestqwlayikavlkaaraiarkveklavsalvhcsdgwdrtsqlvllaqllldpyyrtidglivliekewlafghkfderlggads---vsers PVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHT |.|||.|||..|...|||..||.. .|.|| ... piflqfldclyqvtkqfpsafeytarlllkladys |
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| FYVE | MTMR3.AA | FYVE | 1111-1180 | 35 | 4.3e-33 | 117.18 | SMART | 1-81 (81) | Show / Hide |
Range on Protein: 1111-1180 Range on HMM: 1-81/81 Sequence Identity: 35% (29 aa) TEMTRWLPDHLAAHC-YACDSAFWL-ASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFE---------PSRVCKSCYSSLHP . ..| ||. . || ..|. |.. ..|.||||.||..|||.|||...|.|... .. | |||..||...| ETKPHWQPDEEVDHCCMNCRKEFNFVTNRRHHCRHCGRIFCSKCCNKWIPLPYMGNYKKNGNNQNFTPVRVCDDCYEMMHH |
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| Phosphatase | MTMR3.AA | Subfamily.N_Nematode_1.PD | 395-429 | 42 | 4.7e-06 | 16.2 | In-house | 185-219 (265) | Show / Hide |
Range on Protein: 395-429 Range on HMM: 185-219/265 Sequence Identity: 42% (15 aa) ALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKL || ...|| ... |..|||| | || |||.. . alelleavrgskgPivvhCsaGiGrtGtivaieyi |
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| FYVE | MTMR3.AA | FYVE | 1114-1180 | 37 | 8.9e-29 | 101.19 | Pfam | 1-71 (71) | Show / Hide |
Range on Protein: 1114-1180 Range on HMM: 1-71/71 Sequence Identity: 37% (27 aa) TRWLPDHLAAHCYACDSAFWLA-SRKHHCRNCGNVFC--SSCCNQKVPV--PSQQLFEPSRVCKSCYSSLHP ..| ||. . ||. |...|.. |.||||.||..|| |.|...|... |. . .| |||. ||. | . PHWQPDSEVTHCMICQKPFTFFGRRRHHCRHCGRIFCDDSKCSSHKCIPHPPYYGWNKPVRVCD-CYDDLQK |
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