Gene MTMR4
MTMR4
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of MTMR4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Myotub-related | MTMR4.AA | Myotub-related | 183-341 | 45 | 1.5e-75 | 262.1 | Pfam | 1-121 (121) | Show / Hide |
Range on Protein: 183-341
Range on HMM: 1-121/121
Sequence Identity: 45% (73 aa)
YKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIAKACALDPGTRATGGSLSTGNNDTSEA
|..||.||.|| ||..|.|.||..||.||||.|.||...|| .|||.|.|||||...|||||...||.||..|.||.| |
YEICPTYPAKLVVPKSISDDELKKVAKFRSWGRFPVLCWRHQENGAVICRCSQPLVGWWGWRCKEDEKLVQAIMKANA-D--------------------
CDADFDSSLTACSGVESTAAPQKLLILDARSYTAAVANRAKGGGCECEEYYPNCEVVFM
.....|..|.|||.||.|.||||||||.|.||.|||.|.|||
-----------------MIQSRKMYIVDARPYTNAMANRAKGGGYENEEHYPNWEFVFM
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| Phosphatase | MTMR4.AA | Subfamily.MTMR1.PD | 359-503 | 51 | 2.9e-56 | 179.3 | In-house | 5-149 (149) | Show / Hide |
Range on Protein: 359-503 Range on HMM: 5-149/149 Sequence Identity: 51% (75 aa) VCSQMPDPSNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQE .. | |.||||||.||||.|. ..|. || .|. |..| |.||||||||||.|. .|| .|||.||||..||.||.| .|| ||||| .| || . ivypsideskwlsaleetkwlehiklilagavriadkvesektsvvvhcsdgwdrtaqltslamllldsyyrtikgfevliekewlsfghkfaerighgd NVEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTY . .... |||||..|.| |. .|||. ||||| ||. ...| | knhadadrspvflqfidcvwqvtrqfptafefneeflitildhly |
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| Phosphatase | MTMR4.AA | Subfamily.MTMR3.PD | 369-503 | 83 | 2.1e-82 | 263.8 | In-house | 1-135 (135) | Show / Hide |
Range on Protein: 369-503 Range on HMM: 1-135/135 Sequence Identity: 83% (113 aa) WLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQENVEDQNEQCP .|||||.|||||||||.||||| |.|.||.||||||||||||||||||||||||.||||||||||||.||||..||||||||.|||||.|...|.||.|| flsalektkwlqhlsvllkaavkvvnavdkegrpvlvhcsdgwdrtpqivalakllldpyyrtlegfkvlverewldfghkfadrcghgedsddlnercp VFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTY |||||||.|||| ||||. |||||||||||||||| vflqwldcvhqlkkqfptsfefneaflvklvqhty |
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| Phosphatase | MTMR4.AA | Family.Myotubularin.PD | 365-503 | 59 | 1.3e-68 | 219.0 | In-house | 3-141 (141) | Show / Hide |
Range on Protein: 365-503 Range on HMM: 3-141/141 Sequence Identity: 59% (82 aa) DPSNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQENVEDQN . ..|||.|||||||.|....||||| ....|..|...||||||||||||.|...||..||||||||.|||.||.| .||.|||||.|.||... |...| eekkwlselestkWlehiklllkaavkivekvekektsvlvhcsdGWdrtaqltslaqllldpyyrtieGfevliekeWlsfGhkfaerlghgdksesee EQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTY ..|||||..|.|.|| ||||. |||||.||.|...|.| ersPvflqfidcvyqltkqfptafefnesflikildhly |
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| Phosphatase | MTMR4.AA | Subfamily.C2-MTMR1.PD | 368-502 | 51 | 6.6e-53 | 168.4 | In-house | 5-136 (137) | Show / Hide |
Range on Protein: 368-502 Range on HMM: 5-136/137 Sequence Identity: 51% (69 aa) NWLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQENVedqNEQC .||| ||||.|| ... .|||| .| |.. . ||||||||||| |.|.||..||||||||..|..||.| .|| ||||| .| |. . | |. qwlsqlestqwlayikavlkaaraiarkveklavsalvhcsdgwdrtsqlvllaqllldpyyrtidglivliekewlafghkfderlggadsv---sers PVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHT |.|||.|| ..|. ||||. ||.. .|.|| ... piflqfldclyqvtkqfpsafeytarlllkladys |
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| FYVE | MTMR4.AA | FYVE | 1106-1175 | 38 | 4.4e-34 | 120.48 | SMART | 1-81 (81) | Show / Hide |
Range on Protein: 1106-1175 Range on HMM: 1-81/81 Sequence Identity: 38% (31 aa) TEVTRWVPDHMASHC-YNCDCEFWL-AKRRHHCRNCGNVFCAGCCHLKLPIPDQQLYD---------PVLVCNSCYEHIQV . ..|.||....|| .||..||.. ..||||||.||..||. ||. ..|.|... |. || ||..|||... ETKPHWQPDEEVDHCCMNCRKEFNFVTNRRHHCRHCGRIFCSKCCNKWIPLPYMGNYKKNGNNQNFTPVRVCDDCYEMMHH |
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| Phosphatase | MTMR4.AA | Subfamily.N_Choan_2.PD | 380-422 | 37 | 7e-07 | 18.3 | In-house | 179-220 (266) | Show / Hide |
Range on Protein: 380-422 Range on HMM: 179-220/266 Sequence Identity: 37% (16 aa) QHLSVMLKAAVLVANTVDREGrPVLVHCSDGWDRTPQIVALAK ..| ||.| | . .|... |.|||||.| .|| ..|. . dqllkmlravrrvrkeldkae-PllvHcsaGvgRtGtliaiDi |
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| FYVE | MTMR4.AA | FYVE | 1109-1175 | 37 | 7.7e-29 | 101.41 | Pfam | 1-71 (71) | Show / Hide |
Range on Protein: 1109-1175 Range on HMM: 1-71/71 Sequence Identity: 37% (27 aa) TRWVPDHMASHCYNCDCEFWLA-KRRHHCRNCGNVFC--AGCCHLKLPI--PDQQLYDPVLVCNSCYEHIQV ..|.||....||..|...|.. .||||||.||..|| . |.. | .. |. . . || ||. ||. .| PHWQPDSEVTHCMICQKPFTFFGRRRHHCRHCGRIFCDDSKCSSHKCIPHPPYYGWNKPVRVCD-CYDDLQK |
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