SBF1
Species: Human
Alias: SBF1, DKFZp761D0422, MTMR5, MGC99700
External Links: COSMIC , Entrez Gene
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: Myotubularin
Subfamily: MTMR5
Protein domain

Protein domains of SBF1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
UDENN SBF1.AA uDENN 1-86 35 3.4e-36 131.35 Pfam 1-95 (95) Show / Hide
Range on Protein: 1-86
Range on HMM: 1-95/95
Sequence Identity: 35% (34 aa)

MARLADYFVLVAFGP--HPRGSGEGQGQILQRFPEKDW----EDNPFPQGIELFCQPSGWQLCPER---NPPTFFVAVLTDINSERHYCACLTFW
|.||.|||| .  ..  .. .... ...||...|.||.    .|.|||.....||.| ||.....|    .|.||. ||||....|.|..|.||.
MQRLFDYFVVCGYDKDHMHPLGRSYKPKILDQYPPKDHMQMFWDPPFPDAVPMFCFPDGWDWVTWRDRHYDPQFFSFVLTDEDGSRWYGFCRTFY

DENN SBF1.AA DENN 128-310 31 1e-81 282.56 Pfam 1-207 (207) Show / Hide
Range on Protein: 128-310
Range on HMM: 1-207/207
Sequence Identity: 31% (66 aa)

FAPKTLVLVSRLDHTEVF-RNSLGLIYAIHVEGLN-------------VCLENVIGNLLTC-TVPLAGGSQRTIS---LGAGDRQVIQTPL-ADSL-PV-
..|| ....||... ..| |. |. || .......             . .|..| ||...  .| .|..|...|   ||.......|.|.  ..| || 
WIPKCYCIISRWPWFNTFWRKWLDCIYRRYTSCPHPRIPPSSPRVGMWNPIERYIQNLCYEVPFPPPGRTQVLFSFIPLGVYEPILFQRPSPDSELHPVW

SRCSVALLFRQLGITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQA---ETQELLDVI
. ... .|||.||. |.|.|||..||||...|.|..|..| ..|. ..|||.|......|.||.||.||..|..|.|||.||   ...   . ....||.
EHIDFHPLFRCLGPENCLHLFCCVLTEHRIIFHSSHYAMLTLCCHAVVALLYPFQWQHIYIPICPARLLDYLCAPCPFIMGVHSRYFDSKLLYDPPDDVV

VADLDGG
..|||..
CVDLDTN

UDENN SBF1.AA uDENN 1-86 30 1.8e-34 121.73 SMART 1-114 (114) Show / Hide
Range on Protein: 1-86
Range on HMM: 1-114/114
Sequence Identity: 30% (35 aa)

MARLADYFVLVAFGPHP-----------------------RGSGEGQGQILQRFPEKDWEDNPFPQGIELFCQPSGWQL-----CPERNPPTFFVAVLTD
. ||.|||. .. .. |                         ..  ...||...|||||.|.|||..|..||.| ||..       .|..|.||. ||||
PHRLFDYFCVCGCPKDPGWWPDMHYACYQWEAPGRTGCFCPLQRSYKPEILYQYPEKDWWDFPFPDMIPMFCFPMGWDWCTWPRKTDRPDPQFFTFVLTD

INSERHYCACLTFW
... |.|..|..|.
EDGSRRYGFCRRFY

DENN SBF1.AA DENN 128-310 26 3e-74 253.89 SMART 1-204 (204) Show / Hide
Range on Protein: 128-310
Range on HMM: 1-204/204
Sequence Identity: 26% (54 aa)

FAPKTL-VLVSRLDHTEVFRNSLGLIYAIHV--EGLNVCLENVIGNLLTCTVP--LAGGSQRT------ISLG-AGDRQ---VIQTPLADSLPVSR--CS
..|| . ...|.... ..||. |  .| ...  .. .. ..... .|... ||    |.|..       .... .|...   ... |. ..||..   ..
WTPKCIHCIISHHPWFNWFRKWLNELYRYWQSDHNQHLFHHEFMIYLCHYPVPLPPPGKSIVFMSIVSYFQFHPPGNYYQPIEFCRPDDNRLPHIDENWD

VALLFRQLGITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQAETQELLD----VIVAD
...||..||. |...|||..|.|....|.|..||.| ..|. ..|||.|......|.|||||..|..|..|.|.|.|. . ...| ....|    |.| |
LHELFECLGVENIMQLFCCILLERRIIFHSSNYQMLSMCCHAFVALLYPFQWQHIYIPILPASMLDYLCAPMPYIMGCHSSYFEEVKPEPDEEDDVVVVD

LDGG
.| .
IDTN

DDENN SBF1.AA dDENN 363-432 37 6.2e-23 83.71 Pfam 1-77 (77) Show / Hide
Range on Protein: 363-432
Range on HMM: 1-77/77
Sequence Identity: 37% (29 aa)

QDKELRAVFLRLFAQLLQGYRWCLHVVRIHPEP----VIRFHKAAFLGQ-RGLVEDDFLMKVLEG--MAFAGFVSER
 ....|..|||.||||...||..|   |.||.|    .. |.|.||| . |   . .||....|   ..||.|. ||
HNQQVREAFLRFFAQLFGHYRNFLRYIRQHPRPWTDQMYTFQKEAFLKSRRPKSHRPFLKQFMETQVQMFAQFIQER

SBF2 SBF1.AA SBF2 540-764 64 1.7e-167 562.23 Pfam 1-233 (233) Show / Hide
Range on Protein: 540-764
Range on HMM: 1-233/233
Sequence Identity: 64% (153 aa)

PSGPPMT-------AILERCSGLHVNSA---RRLEVVRNCISYVFEGKMLEAKKLLPAVLRALKGRAARRCLAQELHLHVQQNRA-VLDHQQFDFVVRMM
| |||..       .|.|..||.. |||   |||||.||||||.|..|.|||||..|||||||||||||.||..||.||.||||. ||||||||.|||||
PMGPPVNTIVPGSMSIMEKHSGMFHNSALMLRRLEVLRNCISYIFDNKILEAKKMFPAVLRALKGRAARICLCRELNLHCQQNRHFVLDHQQFDMVVRMM

NCCLQDCTSLDEHGIAAALLPLVTAFCRKLSPGVTQFAYSCVQEHVVWSTPQFWEAMFYGDVQTHIRALYLEPTEDLAPAQEVGEAPSQEDERSALDVAS
||.||||.|.||.|.|||||||.|||||||.|||.||||.|||.|.||...|||||.||.|||.|||.|||   .  .. |. ... ....|..|...|.
NCALQDCCSMDEYGVAAALLPLSTAFCRKLCPGVHQFAYTCVQDHPVWKNQQFWEACFYQDVQNHIRELYL---NMHHDEQKTWSDWCHKQEPCAMEIAA

EQRRLWPTLSREKQQELVQKEESTVFSQAIHYANRM
||.|||||...||||||||||||||.||||||||||
EQMRLWPTMDKEKQQELVQKEESTVYSQAIHYANRM

DDENN SBF1.AA dDENN 363-432 34 3.8e-22 80.82 SMART 1-84 (84) Show / Hide
Range on Protein: 363-432
Range on HMM: 1-84/84
Sequence Identity: 34% (29 aa)

QDKELR-AVFLRLF--AQLLQG--YRWCLH--------VVRIHPEPVIRFHKAAFLGQRGLVE-DDFLMKVLEGMAFAGFVSER
.....| |.|||.|  .||...  || .|.          |.||||.| |.|..||..|   .  .|| ...| ..|..|. ||
LNDQIREACFLRFFNYVQLFGHVDYRNYLRHHMIQQAYTWRKHPEPHITFNKESFLKSRPSHHMRPFLKMFCETQMFSQFIEER

GRAM SBF1.AA GRAM 882-968 13 1e-14 56.1 SMART 1-80 (80) Show / Hide
Range on Protein: 882-968
Range on HMM: 1-80/80
Sequence Identity: 13% (13 aa)

PKLLRPRLLPGEECVLDG------LRVYLLPDGREEGAGGSAGGPALLPAEGAVFLTTYRVIFTGMPTDPLVGEQVVVRSFPVAALTKEKRIS
 |. ..  || .| ...        ..||. ..              .|. | .........| . ... .. .|......| | .|. ....
EKFRQHFKLPPNEKLINDCKKEVTYSCYLWRTY-------------DIPVQGHMYISNNHICFCSNMFGWMTCPQYYKVVIPWADITRIEKMT

SBF1.AA Myotub-related 1159-1252 26 7.2e-32 116.99 Pfam 1-121 (121) Show / Hide
Range on Protein: 1159-1252
Range on HMM: 1-121/121
Sequence Identity: 26% (32 aa)

YAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRSG----GL-HGKG-----VVGLFKAQNA---PSPGQSQADS---------
|.||..||..|.||.|..| .|..|.......||||.|||  ...||..|..    |. ....     .| .....||   .|  .   |.         
YEICPTYPAKLVVPKSISDDELKKVAKFRSWGRFPVLCWRHQENGAVICRCSQPLVGWWGWRCKEDEKLVQAIMKANADMIQSRKMYIVDARPYTNAMAN

----SSLE-QEKYLQAVVSSM
    .. | .|.| ....  |
RAKGGGYENEEHYPNWEFVFM

GRAM SBF1.AA GRAM 882-968 12 4.1e-14 53.49 Pfam 1-78 (78) Show / Hide
Range on Protein: 882-968
Range on HMM: 1-78/78
Sequence Identity: 12% (12 aa)

PKLLRPRL--LPGEECVLDG----LRVYLLPDGREEGAGGSAGGPALLPAEGAVFLTTYRVIFTGMPTDPLVGEQVVVRSFPVAALTKEKRIS
.|.  .    ||..|....      ...|  ..             ..|. |....|...|.| ... ....   .... .| ...|. ....
EKFRKHFKDPLPPNEKLIMDCNVTYSCCLWRPF------------TKIPVQGRMYITNHHVCFYSDKFGWET---YYKMVIPWNDITRVEKMQ

Phosphatase SBF1.AA Family.Myotubularin.PD 1408-1540 48 2.6e-47 148.4 In-house 5-139 (141) Show / Hide
Range on Protein: 1408-1540
Range on HMM: 5-139/141
Sequence Identity: 48% (65 aa)

ASFLRSLEDSEWLIQIHKLLQVSVLVVELLDSG-SSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAG-QSSGF
...| .||...|| .|..||...| .|| ...  .||||   |||| |.|..||.||| ||.|||.|||..|.|||||||||.|..|  |.    ...  
kkwlselestkWlehiklllkaavkivekvekektsvlvhcsdGWdrtaqltslaqllldpyyrtieGfevliekeWlsfGhkfaerlghgdkseseeer

TPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYH
.||||||.|||.|.. |||..|||.. .|  .  |
sPvflqfidcvyqltkqfptafefnesflikildh

Phosphatase SBF1.AA Subfamily.MTMR3.PD 1410-1540 51 1.5e-43 136.3 In-house 1-133 (135) Show / Hide
Range on Protein: 1410-1540
Range on HMM: 1-133/135
Sequence Identity: 51% (67 aa)

FLRSLEDSEWLIQIHKLLQVSVLVVELLDS-GSSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLA-GQSSGFTP
|| .||...|| .. .||. .| ||. .|  |  |||   |||| |.|.|.| .|| ||.|||||||..|||.|||.|||.|. |  |.. .  .|||||
flsalektkwlqhlsvllkaavkvvnavdkegrpvlvhcsdgwdrtpqivalakllldpyyrtlegfkvlverewldfghkfadrcghgedsddlnercp

VFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYH
.||||||.. |||  |||.. .|  |  |    
vflqwldcvhqlkkqfptsfefneaflvklvqh

Phosphatase SBF1.AA Subfamily.C2-MTMR1.PD 1410-1539 44 6.4e-40 124.7 In-house 6-134 (137) Show / Hide
Range on Protein: 1410-1539
Range on HMM: 6-134/137
Sequence Identity: 44% (57 aa)

FLRSLEDSEWLIQIHKLLQVSVLVVELLDS-GSSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHtlAGQSSGFTPV
.|  ||...||  |. .|. .  .   ..  . | ||   |||| |.|.|.| ||| ||.|||..|. .|.|||||.|||.| .|.  |  .|  .|.||
wlsqlestqwlayikavlkaaraiarkveklavsalvhcsdgwdrtsqlvllaqllldpyyrtidglivliekewlafghkfderlgg--adsvserspi

FLQFLDCVHQVHLQFPMEFEFSQFYLKFLGY
|||||..||. |||  ||..  .| .|    
flqfldclyqvtkqfpsafeytarlllklad

Phosphatase SBF1.AA Subfamily.MTMR1.PD 1408-1535 46 1.7e-38 120.0 In-house 13-142 (149) Show / Hide
Range on Protein: 1408-1535
Range on HMM: 13-142/149
Sequence Identity: 46% (59 aa)

ASFLRSLEDSEWLIQIHKLLQVSVLVVELLDSG-SSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAGQSS-GF
. .| .||...|| .|. .|. .| ... ..|  .||.|   |||| |.|. ||  || |..|||..|| .|.|||||||||.|..||    ..    .|
skwlsaleetkwlehiklilagavriadkvesektsvvvhcsdgwdrtaqltslamllldsyyrtikgfevliekewlsfghkfaerighgdknhadadr

TPVFLQFLDCVHQVHLQFPMEFEFSQFYLK
|||||.||| ||  |||. |||.. .|   
spvflqfidcvwqvtrqfptafefneefli

PH SBF1.AA PH 1788-1893 26 8.5e-20 73.01 SMART 1-82 (82) Show / Hide
Range on Protein: 1788-1893
Range on HMM: 1-82/82
Sequence Identity: 26% (28 aa)

RSYEGTLYKKGAFMKPWKARWFVLDKTKHQLRYYDHRVDTECKGVIDLAEVEAVAPGTPTMGAPKTVDEKAFFDVKTTRRVYNFCAQDVPSAQQWVDRIQ
  .||.||||.     || |||||.   ..| ||. .   ..||.|.| ... .                  | ...  |.| |.. .  ..|.|.. ||
VIKEGWLYKKS--K-RWKKRWFVLFN--DCLYYYKDK---KPKGSIPLSDCTVRE-P--------------CFEIHH-DRTYYFQCESEEEMQEWMQAIQ

SCLSDA
......
KAIHNN

PH SBF1.AA PH 1788-1891 29 2.5e-16 61.53 Pfam 1-92 (92) Show / Hide
Range on Protein: 1788-1891
Range on HMM: 1-92/92
Sequence Identity: 29% (31 aa)

RSYEGTLYKKGAFMKPWKARWFVLDKTKHQLRYYDHRVDTECKGVIDLAEVEAVAPGTPTMGAPKTVDEKAFFDVKTTRR-VYNFCAQDVPSAQQWVDRI
  .|| |.||| . | || |||||     .| ||...   ..||.|.| ... . . ..        ...  | ..|  | .| |.| .  ....|.. |
VIKEGWLHKKG-KRKSWKKRWFVLFN--NCLYYYKDDK-YRPKGSIPLSDCQVTKVPDN--------KRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAI

QSCLS
||...
QSACR

Sequence
Name Sequence Type Origin Length Description Download
SBF1.AA Protein None 1893 None Fasta, JSON
SBF1.NA RNA None 5679 None Fasta, JSON