Gene SBF1
SBF1
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of SBF1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| UDENN | SBF1.AA | uDENN | 1-86 | 35 | 3.4e-36 | 131.35 | Pfam | 1-95 (95) | Show / Hide |
Range on Protein: 1-86 Range on HMM: 1-95/95 Sequence Identity: 35% (34 aa) MARLADYFVLVAFGP--HPRGSGEGQGQILQRFPEKDW----EDNPFPQGIELFCQPSGWQLCPER---NPPTFFVAVLTDINSERHYCACLTFW |.||.|||| . .. .. .... ...||...|.||. .|.|||.....||.| ||.....| .|.||. ||||....|.|..|.||. MQRLFDYFVVCGYDKDHMHPLGRSYKPKILDQYPPKDHMQMFWDPPFPDAVPMFCFPDGWDWVTWRDRHYDPQFFSFVLTDEDGSRWYGFCRTFY |
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| DENN | SBF1.AA | DENN | 128-310 | 31 | 1e-81 | 282.56 | Pfam | 1-207 (207) | Show / Hide |
Range on Protein: 128-310 Range on HMM: 1-207/207 Sequence Identity: 31% (66 aa) FAPKTLVLVSRLDHTEVF-RNSLGLIYAIHVEGLN-------------VCLENVIGNLLTC-TVPLAGGSQRTIS---LGAGDRQVIQTPL-ADSL-PV- ..|| ....||... ..| |. |. || ....... . .|..| ||... .| .|..|...| ||.......|.|. ..| || WIPKCYCIISRWPWFNTFWRKWLDCIYRRYTSCPHPRIPPSSPRVGMWNPIERYIQNLCYEVPFPPPGRTQVLFSFIPLGVYEPILFQRPSPDSELHPVW SRCSVALLFRQLGITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQA---ETQELLDVI . ... .|||.||. |.|.|||..||||...|.|..|..| ..|. ..|||.|......|.||.||.||..|..|.|||.|| ... . ....||. EHIDFHPLFRCLGPENCLHLFCCVLTEHRIIFHSSHYAMLTLCCHAVVALLYPFQWQHIYIPICPARLLDYLCAPCPFIMGVHSRYFDSKLLYDPPDDVV VADLDGG ..|||.. CVDLDTN |
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| UDENN | SBF1.AA | uDENN | 1-86 | 30 | 1.8e-34 | 121.73 | SMART | 1-114 (114) | Show / Hide |
Range on Protein: 1-86 Range on HMM: 1-114/114 Sequence Identity: 30% (35 aa) MARLADYFVLVAFGPHP-----------------------RGSGEGQGQILQRFPEKDWEDNPFPQGIELFCQPSGWQL-----CPERNPPTFFVAVLTD . ||.|||. .. .. | .. ...||...|||||.|.|||..|..||.| ||.. .|..|.||. |||| PHRLFDYFCVCGCPKDPGWWPDMHYACYQWEAPGRTGCFCPLQRSYKPEILYQYPEKDWWDFPFPDMIPMFCFPMGWDWCTWPRKTDRPDPQFFTFVLTD INSERHYCACLTFW ... |.|..|..|. EDGSRRYGFCRRFY |
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| DENN | SBF1.AA | DENN | 128-310 | 26 | 3e-74 | 253.89 | SMART | 1-204 (204) | Show / Hide |
Range on Protein: 128-310 Range on HMM: 1-204/204 Sequence Identity: 26% (54 aa) FAPKTL-VLVSRLDHTEVFRNSLGLIYAIHV--EGLNVCLENVIGNLLTCTVP--LAGGSQRT------ISLG-AGDRQ---VIQTPLADSLPVSR--CS ..|| . ...|.... ..||. | .| ... .. .. ..... .|... || |.|.. .... .|... ... |. ..||.. .. WTPKCIHCIISHHPWFNWFRKWLNELYRYWQSDHNQHLFHHEFMIYLCHYPVPLPPPGKSIVFMSIVSYFQFHPPGNYYQPIEFCRPDDNRLPHIDENWD VALLFRQLGITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQAETQELLD----VIVAD ...||..||. |...|||..|.|....|.|..||.| ..|. ..|||.|......|.|||||..|..|..|.|.|.|. . ...| ....| |.| | LHELFECLGVENIMQLFCCILLERRIIFHSSNYQMLSMCCHAFVALLYPFQWQHIYIPILPASMLDYLCAPMPYIMGCHSSYFEEVKPEPDEEDDVVVVD LDGG .| . IDTN |
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| DDENN | SBF1.AA | dDENN | 363-432 | 37 | 6.2e-23 | 83.71 | Pfam | 1-77 (77) | Show / Hide |
Range on Protein: 363-432 Range on HMM: 1-77/77 Sequence Identity: 37% (29 aa) QDKELRAVFLRLFAQLLQGYRWCLHVVRIHPEP----VIRFHKAAFLGQ-RGLVEDDFLMKVLEG--MAFAGFVSER ....|..|||.||||...||..| |.||.| .. |.|.||| . | . .||....| ..||.|. || HNQQVREAFLRFFAQLFGHYRNFLRYIRQHPRPWTDQMYTFQKEAFLKSRRPKSHRPFLKQFMETQVQMFAQFIQER |
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| SBF2 | SBF1.AA | SBF2 | 540-764 | 64 | 1.7e-167 | 562.23 | Pfam | 1-233 (233) | Show / Hide |
Range on Protein: 540-764 Range on HMM: 1-233/233 Sequence Identity: 64% (153 aa) PSGPPMT-------AILERCSGLHVNSA---RRLEVVRNCISYVFEGKMLEAKKLLPAVLRALKGRAARRCLAQELHLHVQQNRA-VLDHQQFDFVVRMM | |||.. .|.|..||.. ||| |||||.||||||.|..|.|||||..|||||||||||||.||..||.||.||||. ||||||||.||||| PMGPPVNTIVPGSMSIMEKHSGMFHNSALMLRRLEVLRNCISYIFDNKILEAKKMFPAVLRALKGRAARICLCRELNLHCQQNRHFVLDHQQFDMVVRMM NCCLQDCTSLDEHGIAAALLPLVTAFCRKLSPGVTQFAYSCVQEHVVWSTPQFWEAMFYGDVQTHIRALYLEPTEDLAPAQEVGEAPSQEDERSALDVAS ||.||||.|.||.|.|||||||.|||||||.|||.||||.|||.|.||...|||||.||.|||.|||.||| . .. |. ... ....|..|...|. NCALQDCCSMDEYGVAAALLPLSTAFCRKLCPGVHQFAYTCVQDHPVWKNQQFWEACFYQDVQNHIRELYL---NMHHDEQKTWSDWCHKQEPCAMEIAA EQRRLWPTLSREKQQELVQKEESTVFSQAIHYANRM ||.|||||...||||||||||||||.|||||||||| EQMRLWPTMDKEKQQELVQKEESTVYSQAIHYANRM |
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| DDENN | SBF1.AA | dDENN | 363-432 | 34 | 3.8e-22 | 80.82 | SMART | 1-84 (84) | Show / Hide |
Range on Protein: 363-432 Range on HMM: 1-84/84 Sequence Identity: 34% (29 aa) QDKELR-AVFLRLF--AQLLQG--YRWCLH--------VVRIHPEPVIRFHKAAFLGQRGLVE-DDFLMKVLEGMAFAGFVSER .....| |.|||.| .||... || .|. |.||||.| |.|..||..| . .|| ...| ..|..|. || LNDQIREACFLRFFNYVQLFGHVDYRNYLRHHMIQQAYTWRKHPEPHITFNKESFLKSRPSHHMRPFLKMFCETQMFSQFIEER |
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| GRAM | SBF1.AA | GRAM | 882-968 | 13 | 1e-14 | 56.1 | SMART | 1-80 (80) | Show / Hide |
Range on Protein: 882-968 Range on HMM: 1-80/80 Sequence Identity: 13% (13 aa) PKLLRPRLLPGEECVLDG------LRVYLLPDGREEGAGGSAGGPALLPAEGAVFLTTYRVIFTGMPTDPLVGEQVVVRSFPVAALTKEKRIS |. .. || .| ... ..||. .. .|. | .........| . ... .. .|......| | .|. .... EKFRQHFKLPPNEKLINDCKKEVTYSCYLWRTY-------------DIPVQGHMYISNNHICFCSNMFGWMTCPQYYKVVIPWADITRIEKMT |
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| Myotub-related | SBF1.AA | Myotub-related | 1159-1252 | 26 | 7.2e-32 | 116.99 | Pfam | 1-121 (121) | Show / Hide |
Range on Protein: 1159-1252
Range on HMM: 1-121/121
Sequence Identity: 26% (32 aa)
YAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRSG----GL-HGKG-----VVGLFKAQNA---PSPGQSQADS---------
|.||..||..|.||.|..| .|..|.......||||.||| ...||..|.. |. .... .| .....|| .| . |.
YEICPTYPAKLVVPKSISDDELKKVAKFRSWGRFPVLCWRHQENGAVICRCSQPLVGWWGWRCKEDEKLVQAIMKANADMIQSRKMYIVDARPYTNAMAN
----SSLE-QEKYLQAVVSSM
.. | .|.| .... |
RAKGGGYENEEHYPNWEFVFM
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| GRAM | SBF1.AA | GRAM | 882-968 | 12 | 4.1e-14 | 53.49 | Pfam | 1-78 (78) | Show / Hide |
Range on Protein: 882-968 Range on HMM: 1-78/78 Sequence Identity: 12% (12 aa) PKLLRPRL--LPGEECVLDG----LRVYLLPDGREEGAGGSAGGPALLPAEGAVFLTTYRVIFTGMPTDPLVGEQVVVRSFPVAALTKEKRIS .|. . ||..|.... ...| .. ..|. |....|...|.| ... .... .... .| ...|. .... EKFRKHFKDPLPPNEKLIMDCNVTYSCCLWRPF------------TKIPVQGRMYITNHHVCFYSDKFGWET---YYKMVIPWNDITRVEKMQ |
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| Phosphatase | SBF1.AA | Family.Myotubularin.PD | 1408-1540 | 48 | 2.6e-47 | 148.4 | In-house | 5-139 (141) | Show / Hide |
Range on Protein: 1408-1540 Range on HMM: 5-139/141 Sequence Identity: 48% (65 aa) ASFLRSLEDSEWLIQIHKLLQVSVLVVELLDSG-SSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAG-QSSGF ...| .||...|| .|..||...| .|| ... .|||| |||| |.|..||.||| ||.|||.|||..|.|||||||||.|..| |. ... kkwlselestkWlehiklllkaavkivekvekektsvlvhcsdGWdrtaqltslaqllldpyyrtieGfevliekeWlsfGhkfaerlghgdkseseeer TPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYH .||||||.|||.|.. |||..|||.. .| . | sPvflqfidcvyqltkqfptafefnesflikildh |
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| Phosphatase | SBF1.AA | Subfamily.MTMR3.PD | 1410-1540 | 51 | 1.5e-43 | 136.3 | In-house | 1-133 (135) | Show / Hide |
Range on Protein: 1410-1540 Range on HMM: 1-133/135 Sequence Identity: 51% (67 aa) FLRSLEDSEWLIQIHKLLQVSVLVVELLDS-GSSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLA-GQSSGFTP || .||...|| .. .||. .| ||. .| | ||| |||| |.|.|.| .|| ||.|||||||..|||.|||.|||.|. | |.. . .||||| flsalektkwlqhlsvllkaavkvvnavdkegrpvlvhcsdgwdrtpqivalakllldpyyrtlegfkvlverewldfghkfadrcghgedsddlnercp VFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYH .||||||.. ||| |||.. .| | | vflqwldcvhqlkkqfptsfefneaflvklvqh |
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| Phosphatase | SBF1.AA | Subfamily.C2-MTMR1.PD | 1410-1539 | 44 | 6.4e-40 | 124.7 | In-house | 6-134 (137) | Show / Hide |
Range on Protein: 1410-1539 Range on HMM: 6-134/137 Sequence Identity: 44% (57 aa) FLRSLEDSEWLIQIHKLLQVSVLVVELLDS-GSSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHtlAGQSSGFTPV .| ||...|| |. .|. . . .. . | || |||| |.|.|.| ||| ||.|||..|. .|.|||||.|||.| .|. | .| .|.|| wlsqlestqwlayikavlkaaraiarkveklavsalvhcsdgwdrtsqlvllaqllldpyyrtidglivliekewlafghkfderlgg--adsvserspi FLQFLDCVHQVHLQFPMEFEFSQFYLKFLGY |||||..||. ||| ||.. .| .| flqfldclyqvtkqfpsafeytarlllklad |
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| Phosphatase | SBF1.AA | Subfamily.MTMR1.PD | 1408-1535 | 46 | 1.7e-38 | 120.0 | In-house | 13-142 (149) | Show / Hide |
Range on Protein: 1408-1535 Range on HMM: 13-142/149 Sequence Identity: 46% (59 aa) ASFLRSLEDSEWLIQIHKLLQVSVLVVELLDSG-SSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAGQSS-GF . .| .||...|| .|. .|. .| ... ..| .||.| |||| |.|. || || |..|||..|| .|.|||||||||.|..|| .. .| skwlsaleetkwlehiklilagavriadkvesektsvvvhcsdgwdrtaqltslamllldsyyrtikgfevliekewlsfghkfaerighgdknhadadr TPVFLQFLDCVHQVHLQFPMEFEFSQFYLK |||||.||| || |||. |||.. .| spvflqfidcvwqvtrqfptafefneefli |
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| PH | SBF1.AA | PH | 1788-1893 | 26 | 8.5e-20 | 73.01 | SMART | 1-82 (82) | Show / Hide |
Range on Protein: 1788-1893 Range on HMM: 1-82/82 Sequence Identity: 26% (28 aa) RSYEGTLYKKGAFMKPWKARWFVLDKTKHQLRYYDHRVDTECKGVIDLAEVEAVAPGTPTMGAPKTVDEKAFFDVKTTRRVYNFCAQDVPSAQQWVDRIQ .||.||||. || |||||. ..| ||. . ..||.|.| ... . | ... |.| |.. . ..|.|.. || VIKEGWLYKKS--K-RWKKRWFVLFN--DCLYYYKDK---KPKGSIPLSDCTVRE-P--------------CFEIHH-DRTYYFQCESEEEMQEWMQAIQ SCLSDA ...... KAIHNN |
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| PH | SBF1.AA | PH | 1788-1891 | 29 | 2.5e-16 | 61.53 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 1788-1891 Range on HMM: 1-92/92 Sequence Identity: 29% (31 aa) RSYEGTLYKKGAFMKPWKARWFVLDKTKHQLRYYDHRVDTECKGVIDLAEVEAVAPGTPTMGAPKTVDEKAFFDVKTTRR-VYNFCAQDVPSAQQWVDRI .|| |.||| . | || ||||| .| ||... ..||.|.| ... . . .. ... | ..| | .| |.| . ....|.. | VIKEGWLHKKG-KRKSWKKRWFVLFN--NCLYYYKDDK-YRPKGSIPLSDCQVTKVPDN--------KRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAI QSCLS ||... QSACR |
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