Gene SBF2
SBF2
Species: Human
Alias: MTMR13, CMT4B2, FLJ22918, FLJ41627, SBF2, KIAA1766, DKFZp779B2327
External Links:
COSMIC
,
Entrez Gene
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of SBF2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| UDENN | SBF2.AA | uDENN | 1-86 | 42 | 1.6e-39 | 142.42 | Pfam | 1-95 (95) | Show / Hide |
Range on Protein: 1-86 Range on HMM: 1-95/95 Sequence Identity: 42% (40 aa) MARLADYFIVVGYDH--EKPGSGEGLGKIIQRFPQKDW----DDTPFPQGIELFCQPGGWQLSRER---KQPTFFVVVLTDIDSDRHYCSCLTFY |.||.|||.|.|||. ..|.... ..||....|.||. .|.|||.....||.| ||.. ..| ..|.||. ||||.|. |.|..|.||| MQRLFDYFVVCGYDKDHMHPLGRSYKPKILDQYPPKDHMQMFWDPPFPDAVPMFCFPDGWDWVTWRDRHYDPQFFSFVLTDEDGSRWYGFCRTFY |
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| DENN | SBF2.AA | DENN | 116-298 | 34 | 4.3e-87 | 300.46 | Pfam | 1-207 (207) | Show / Hide |
Range on Protein: 116-298 Range on HMM: 1-207/207 Sequence Identity: 34% (71 aa) FAPKSLVLVSRLYYPEIF-RACLGLIYTVYVDSLN-------------VSLESLIANLCAC-LVPAAGGSQKLFS---LGAGDRQLIQTPL-HDSL-PI- ..||.....||. . . | | .|. ||..|..... . .|..|.||| . .|..|..|.||| ||.....|.|.|. ...| |. WIPKCYCIISRWPWFNTFWRKWLDCIYRRYTSCPHPRIPPSSPRVGMWNPIERYIQNLCYEVPFPPPGRTQVLFSFIPLGVYEPILFQRPSPDSELHPVW TGTSVALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFKT---DVHELLDVI ..... .||..||..|.|.|||.||||....||| ....|...|.|. .|..|......||||.||.||..|..|.|||.|||| . . ......||. EHIDFHPLFRCLGPENCLHLFCCVLTEHRIIFHSSHYAMLTLCCHAVVALLYPFQWQHIYIPICPARLLDYLCAPCPFIMGVHSRYFDSKLLYDPPDDVV IADLDGG ..|||.. CVDLDTN |
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| UDENN | SBF2.AA | uDENN | 1-86 | 32 | 1.6e-38 | 135.21 | SMART | 1-114 (114) | Show / Hide |
Range on Protein: 1-86 Range on HMM: 1-114/114 Sequence Identity: 32% (37 aa) MARLADYFIVVGYDHEK-----------------------PGSGEGLGKIIQRFPQKDWDDTPFPQGIELFCQPGGWQL-----SRERKQPTFFVVVLTD . ||.|||.|.|..... | .. ...|....|.|||.|.|||..|..||.| ||.. ...|..|.||. |||| PHRLFDYFCVCGCPKDPGWWPDMHYACYQWEAPGRTGCFCPLQRSYKPEILYQYPEKDWWDFPFPDMIPMFCFPMGWDWCTWPRKTDRPDPQFFTFVLTD IDSDRHYCSCLTFY .|. |.|..|..|| EDGSRRYGFCRRFY |
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| DENN | SBF2.AA | DENN | 116-298 | 28 | 3.3e-77 | 263.74 | SMART | 1-204 (204) | Show / Hide |
Range on Protein: 116-298 Range on HMM: 1-204/204 Sequence Identity: 28% (58 aa) FAPKSL-VLVSRLYYPEIFRACLGLIYTVYV--DSLNVSLESLIANLCACLVP--AAGGSQKL------FSLG-AGDRQ---LIQTPLHDSLPITG--TS ..||.. ...|.. ....|| .| .|.... .. ..........|| . || . |.|... |... .|... ... |....|| .. .. WTPKCIHCIISHHPWFNWFRKWLNELYRYWQSDHNQHLFHHEFMIYLCHYPVPLPPPGKSIVFMSIVSYFQFHPPGNYYQPIEFCRPDDNRLPHIDENWD VALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFKTDVHELLD----VIIAD ...||..||..|...|||..|.|....||| ..|.||..|.|. .|..|.... .|||||||..|..|..|.|.|.|.|| . ..| ...| |.. | LHELFECLGVENIMQLFCCILLERRIIFHSSNYQMLSMCCHAFVALLYPFQWQHIYIPILPASMLDYLCAPMPYIMGCHSSYFEEVKPEPDEEDDVVVVD LDGG .| . IDTN |
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| DDENN | SBF2.AA | dDENN | 351-420 | 38 | 1.9e-24 | 89.04 | Pfam | 1-77 (77) | Show / Hide |
Range on Protein: 351-420 Range on HMM: 1-77/77 Sequence Identity: 38% (30 aa) LDKEVRAVFLRLFAQLFQGYRSCLQLIRIHAEP----VIHFHKTAFLGQ-RGLVENDFLTKVLSG--MAFAGFVSER ....||..|||.|||||..||..|. ||.| .| ...|.| ||| . | . .||.... ..||.|. || HNQQVREAFLRFFAQLFGHYRNFLRYIRQHPRPWTDQMYTFQKEAFLKSRRPKSHRPFLKQFMETQVQMFAQFIQER |
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| SBF2 | SBF2.AA | SBF2 | 528-754 | 61 | 3.3e-171 | 574.71 | Pfam | 1-233 (233) | Show / Hide |
Range on Protein: 528-754 Range on HMM: 1-233/233 Sequence Identity: 61% (148 aa) PAGPPVV-------SIMDKVTTVF-NSA---QRLEVVRNCISFIFENKILETEKTLPAALRALKGKAARQCLTDELGLHVQQNRA-ILDHQQFDYIIRMM |.||||. |||.| ...| ||| .||||.|||||.||.|||||..|..||.||||||.|||.||..|| ||.||||. .|||||||...||| PMGPPVNTIVPGSMSIMEKHSGMFHNSALMLRRLEVLRNCISYIFDNKILEAKKMFPAVLRALKGRAARICLCRELNLHCQQNRHFVLDHQQFDMVVRMM NCTLQDCSSLEEYNIAAALLPLTSAFYRKLAPGVSQFAYTCVQDHPIWTNQQFWETTFYNAVQEQVRSLYLSAKEDNHAPHLKQKDKLPDDHYQEKTAMD ||.||||.|..||..|||||||..||.|||.|||.|||||||||||.|.||||||..||. ||...|.||| ...| .||... ..|.||..||. NCALQDCCSMDEYGVAAALLPLSTAFCRKLCPGVHQFAYTCVQDHPVWKNQQFWEACFYQDVQNHIRELYL------NMHHDEQKTWSDWCHKQEPCAME LAAEQLRLWPTLSKSTQQELVQHEESTVFSQAIHFANLM .||||.|||||..|..||||||.|||||.|||||.||.| IAAEQMRLWPTMDKEKQQELVQKEESTVYSQAIHYANRM |
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| DDENN | SBF2.AA | dDENN | 351-420 | 34 | 5.6e-24 | 86.89 | SMART | 1-84 (84) | Show / Hide |
Range on Protein: 351-420 Range on HMM: 1-84/84 Sequence Identity: 34% (29 aa) LDKEVR-AVFLRLF--AQLFQG--YRSCLQ--------LIRIHAEPVIHFHKTAFLGQRGLVE-NDFLTKVLSGMAFAGFVSER |....| |.|||.| .|||.. ||..|. .|.| ||.|.|.| .||..| . .||.... ..|..|. || LNDQIREACFLRFFNYVQLFGHVDYRNYLRHHMIQQAYTWRKHPEPHITFNKESFLKSRPSHHMRPFLKMFCETQMFSQFIEER |
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| GRAM | SBF2.AA | GRAM | 871-957 | 17 | 2.9e-15 | 57.96 | SMART | 1-80 (80) | Show / Hide |
Range on Protein: 871-957 Range on HMM: 1-80/80 Sequence Identity: 17% (16 aa) PKILRPALLPGEEIVCEG------LRVLLDPDGREEATGGLLGGPQLLPAEGALFLTTYRILFRGTPHDQLVGEQTVVRSFPIASITKEKKIT |. .. || .| .. .. | .. .|. | .......|.|.. . .... .|......|.|.||. .|.| EKFRQHFKLPPNEKLINDCKKEVTYSCYLWRTY-------------DIPVQGHMYISNNHICFCSNMFGWMTCPQYYKVVIPWADITRIEKMT |
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| Myotub-related | SBF2.AA | Myotub-related | 1147-1242 | 20 | 7.9e-25 | 93.6 | Pfam | 1-121 (121) | Show / Hide |
Range on Protein: 1147-1242 Range on HMM: 1-121/121 Sequence Identity: 20% (26 aa) YSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRSG----GF-HGKG-----VVGLFKSQNS---------------------P |..|..||..||||....|. | .||......|.||.|| . ..|....|.. |. .... .| .....|. YEICPTYPAKLVVPKSISDDELKKVAKFRSWGRFPVLCWRHQENGAVICRCSQPLVGWWGWRCKEDEKLVQAIMKANADMIQSRKMYIVDARPYTNAMAN QAAPTSSLESSSSIE-QEKYLQALLNAV .|. .. | .|.| .. . .. RAKG-------GGYENEEHYPNWEFVFM |
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| GRAM | SBF2.AA | GRAM | 871-957 | 13 | 1.5e-09 | 37.25 | Pfam | 1-78 (78) | Show / Hide |
Range on Protein: 871-957 Range on HMM: 1-78/78 Sequence Identity: 13% (13 aa) PKILRPAL--LPGEEIVCEG----LRVLLDPDGREEATGGLLGGPQLLPAEGALFLTTYRILFRGTPHDQLVGEQTVVRSFPIASITKEKKIT .|. . ||..| . . .. | .. ..|. |....|.... |.. . . .. .... .|...||. .|.. EKFRKHFKDPLPPNEKLIMDCNVTYSCCLWRPF------------TKIPVQGRMYITNHHVCFYSDKFGWET---YYKMVIPWNDITRVEKMQ |
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| Phosphatase | SBF2.AA | Subfamily.MTMR1.PD | 1365-1498 | 47 | 2.8e-39 | 122.5 | In-house | 7-142 (149) | Show / Hide |
Range on Protein: 1365-1498 Range on HMM: 7-142/149 Sequence Identity: 47% (63 aa) IPTDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVLE-NGSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSLTL-N |. | .|.|| ...|. ... |.. || ... .| . .||.| .||| |||.||| || |..|||..||..|.|||||||||||..| | ypsideskwlsaleetkwlehiklilagavriadkvesektsvvvhcsdgwdrtaqltslamllldsyyrtikgfevliekewlsfghkfaerighgdkn CQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLK . .||||||.||| || .|.|| |||| ..| hadadrspvflqfidcvwqvtrqfptafefneefli |
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| Phosphatase | SBF2.AA | Family.Myotubularin.PD | 1370-1503 | 47 | 1.9e-46 | 145.6 | In-house | 4-139 (141) | Show / Hide |
Range on Protein: 1370-1503 Range on HMM: 4-139/141 Sequence Identity: 47% (64 aa) EVTFLKALGDSEWFPQLHRIMQLAVVVSEVLEN-GSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSLTLN-CQGSG | ..|..| ...|. ... ... || . | .|. ..|||| .||| |||.|||.||| ||.|||.|||..|.|||||||||||..| . . . . ekkwlselestkWlehiklllkaavkivekvekektsvlvhcsdGWdrtaqltslaqllldpyyrtieGfevliekeWlsfGhkfaerlghgdkseseee FAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFH .||||||.|||.|...|.||.|||| .| .. | rsPvflqfidcvyqltkqfptafefnesflikildh |
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| Phosphatase | SBF2.AA | Subfamily.MTMR3.PD | 1374-1503 | 47 | 2.4e-42 | 132.4 | In-house | 2-133 (135) | Show / Hide |
Range on Protein: 1374-1503 Range on HMM: 2-133/135 Sequence Identity: 47% (62 aa) LKALGDSEWFPQLHRIMQLAVVVSEVLE-NGSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSLTLNCQG-SGFAPV | || ...|. .| ... || |.. .. .| ||| .||| |.|...| .|| ||.|||||||..|||.|||.|||||..|. .. . . .||| lsalektkwlqhlsvllkaavkvvnavdkegrpvlvhcsdgwdrtpqivalakllldpyyrtlegfkvlverewldfghkfadrcghgedsddlnercpv FLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFH ||.||||||...|.|| |||| .| |. | flqwldcvhqlkkqfptsfefneaflvklvqh |
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| Phosphatase | SBF2.AA | Subfamily.C2-MTMR1.PD | 1369-1503 | 40 | 2e-40 | 126.4 | In-house | 2-135 (137) | Show / Hide |
Range on Protein: 1369-1503 Range on HMM: 2-135/137 Sequence Identity: 40% (55 aa) SEVTFLKALGDSEWFPQLHRIMQLAVVVSEVLEN-GSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSLTlNCQgSG |.| .| | ...|. .. ... | .. .|. . | || .||| |.|...| ||| ||.|||..|...|.|||||.|||||.| . .. | sdvqwlsqlestqwlayikavlkaaraiarkveklavsalvhcsdgwdrtsqlvllaqllldpyyrtidglivliekewlafghkfderlgga-dsv-se FAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFH .|.|||||||..||. |.|. ||.. .| .|| . rspiflqfldclyqvtkqfpsafeytarlllklady |
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| PH | SBF2.AA | PH | 1744-1849 | 27 | 3.6e-21 | 77.58 | SMART | 1-82 (82) | Show / Hide |
Range on Protein: 1744-1849 Range on HMM: 1-82/82 Sequence Identity: 27% (29 aa) RSFEGTLYKRGALLKGWKPRWFVLDVTKHQLRYYDSGEDTSCKGHIDLAEVEMVIPAGPSMGAPKHTSDKAFFDLKTSKRVYNFCAQDGQSAQQWMDKIQ ||.|||.. . .||.|||||. ..| ||.. ..|| |.| ... . . | ... .|.| |.. . ...|.||. || VIKEGWLYKKS--K-RWKKRWFVLFN--DCLYYYKDK---KPKGSIPLSDCTVRE-P--------------CFEIHH-DRTYYFQCESEEEMQEWMQAIQ SCISDA ..|... KAIHNN |
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| PH | SBF2.AA | PH | 1744-1847 | 29 | 7.2e-18 | 67.08 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 1744-1847 Range on HMM: 1-92/92 Sequence Identity: 29% (31 aa) RSFEGTLYKRGALLKGWKPRWFVLDVTKHQLRYYDSGEDTSCKGHIDLAEVEMVIPAGPSMGAPKHTSDKAFFDLKTSKR-VYNFCAQDGQSAQQWMDKI || |.|.| .|.||.||||| .| ||... ..|| |.| ... ... . .. | ..| | .| |.| . .....||. | VIKEGWLHKKG-KRKSWKKRWFVLFN--NCLYYYKDDK-YRPKGSIPLSDCQVTKVPDN--------KRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAI QSCIS ||... QSACR |
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