SBF2
Species: Human
Alias: MTMR13, CMT4B2, FLJ22918, FLJ41627, SBF2, KIAA1766, DKFZp779B2327
External Links: COSMIC , Entrez Gene
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: Myotubularin
Subfamily: MTMR5
Protein domain

Protein domains of SBF2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
UDENN SBF2.AA uDENN 1-86 42 1.6e-39 142.42 Pfam 1-95 (95) Show / Hide
Range on Protein: 1-86
Range on HMM: 1-95/95
Sequence Identity: 42% (40 aa)

MARLADYFIVVGYDH--EKPGSGEGLGKIIQRFPQKDW----DDTPFPQGIELFCQPGGWQLSRER---KQPTFFVVVLTDIDSDRHYCSCLTFY
|.||.|||.|.|||.  ..|.... ..||....|.||.    .|.|||.....||.| ||.. ..|   ..|.||. ||||.|. |.|..|.|||
MQRLFDYFVVCGYDKDHMHPLGRSYKPKILDQYPPKDHMQMFWDPPFPDAVPMFCFPDGWDWVTWRDRHYDPQFFSFVLTDEDGSRWYGFCRTFY

DENN SBF2.AA DENN 116-298 34 4.3e-87 300.46 Pfam 1-207 (207) Show / Hide
Range on Protein: 116-298
Range on HMM: 1-207/207
Sequence Identity: 34% (71 aa)

FAPKSLVLVSRLYYPEIF-RACLGLIYTVYVDSLN-------------VSLESLIANLCAC-LVPAAGGSQKLFS---LGAGDRQLIQTPL-HDSL-PI-
..||.....||. . . | | .|. ||..|.....             . .|..|.||| .  .|..|..|.|||   ||.....|.|.|. ...| |. 
WIPKCYCIISRWPWFNTFWRKWLDCIYRRYTSCPHPRIPPSSPRVGMWNPIERYIQNLCYEVPFPPPGRTQVLFSFIPLGVYEPILFQRPSPDSELHPVW

TGTSVALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFKT---DVHELLDVI
..... .||..||..|.|.|||.||||....||| ....|...|.|. .|..|......||||.||.||..|..|.|||.|||| . .   ......||.
EHIDFHPLFRCLGPENCLHLFCCVLTEHRIIFHSSHYAMLTLCCHAVVALLYPFQWQHIYIPICPARLLDYLCAPCPFIMGVHSRYFDSKLLYDPPDDVV

IADLDGG
..|||..
CVDLDTN

UDENN SBF2.AA uDENN 1-86 32 1.6e-38 135.21 SMART 1-114 (114) Show / Hide
Range on Protein: 1-86
Range on HMM: 1-114/114
Sequence Identity: 32% (37 aa)

MARLADYFIVVGYDHEK-----------------------PGSGEGLGKIIQRFPQKDWDDTPFPQGIELFCQPGGWQL-----SRERKQPTFFVVVLTD
. ||.|||.|.|.....                       | ..  ...|....|.|||.|.|||..|..||.| ||..     ...|..|.||. ||||
PHRLFDYFCVCGCPKDPGWWPDMHYACYQWEAPGRTGCFCPLQRSYKPEILYQYPEKDWWDFPFPDMIPMFCFPMGWDWCTWPRKTDRPDPQFFTFVLTD

IDSDRHYCSCLTFY
.|. |.|..|..||
EDGSRRYGFCRRFY

DENN SBF2.AA DENN 116-298 28 3.3e-77 263.74 SMART 1-204 (204) Show / Hide
Range on Protein: 116-298
Range on HMM: 1-204/204
Sequence Identity: 28% (58 aa)

FAPKSL-VLVSRLYYPEIFRACLGLIYTVYV--DSLNVSLESLIANLCACLVP--AAGGSQKL------FSLG-AGDRQ---LIQTPLHDSLPITG--TS
..||.. ...|.. ....|| .|  .|....  .. ..........|| . ||  . |.|...      |... .|...   ... |....|| ..  ..
WTPKCIHCIISHHPWFNWFRKWLNELYRYWQSDHNQHLFHHEFMIYLCHYPVPLPPPGKSIVFMSIVSYFQFHPPGNYYQPIEFCRPDDNRLPHIDENWD

VALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFKTDVHELLD----VIIAD
...||..||..|...|||..|.|....||| ..|.||..|.|. .|..|.... .|||||||..|..|..|.|.|.|.|| . ..| ...|    |.. |
LHELFECLGVENIMQLFCCILLERRIIFHSSNYQMLSMCCHAFVALLYPFQWQHIYIPILPASMLDYLCAPMPYIMGCHSSYFEEVKPEPDEEDDVVVVD

LDGG
.| .
IDTN

DDENN SBF2.AA dDENN 351-420 38 1.9e-24 89.04 Pfam 1-77 (77) Show / Hide
Range on Protein: 351-420
Range on HMM: 1-77/77
Sequence Identity: 38% (30 aa)

LDKEVRAVFLRLFAQLFQGYRSCLQLIRIHAEP----VIHFHKTAFLGQ-RGLVENDFLTKVLSG--MAFAGFVSER
....||..|||.|||||..||..|. ||.| .|    ...|.| ||| . |   . .||....    ..||.|. ||
HNQQVREAFLRFFAQLFGHYRNFLRYIRQHPRPWTDQMYTFQKEAFLKSRRPKSHRPFLKQFMETQVQMFAQFIQER

SBF2 SBF2.AA SBF2 528-754 61 3.3e-171 574.71 Pfam 1-233 (233) Show / Hide
Range on Protein: 528-754
Range on HMM: 1-233/233
Sequence Identity: 61% (148 aa)

PAGPPVV-------SIMDKVTTVF-NSA---QRLEVVRNCISFIFENKILETEKTLPAALRALKGKAARQCLTDELGLHVQQNRA-ILDHQQFDYIIRMM
|.||||.       |||.| ...| |||   .||||.|||||.||.|||||..|..||.||||||.|||.||..|| ||.||||. .|||||||...|||
PMGPPVNTIVPGSMSIMEKHSGMFHNSALMLRRLEVLRNCISYIFDNKILEAKKMFPAVLRALKGRAARICLCRELNLHCQQNRHFVLDHQQFDMVVRMM

NCTLQDCSSLEEYNIAAALLPLTSAFYRKLAPGVSQFAYTCVQDHPIWTNQQFWETTFYNAVQEQVRSLYLSAKEDNHAPHLKQKDKLPDDHYQEKTAMD
||.||||.|..||..|||||||..||.|||.|||.|||||||||||.|.||||||..||. ||...|.|||      ...| .||... ..|.||..||.
NCALQDCCSMDEYGVAAALLPLSTAFCRKLCPGVHQFAYTCVQDHPVWKNQQFWEACFYQDVQNHIRELYL------NMHHDEQKTWSDWCHKQEPCAME

LAAEQLRLWPTLSKSTQQELVQHEESTVFSQAIHFANLM
.||||.|||||..|..||||||.|||||.|||||.||.|
IAAEQMRLWPTMDKEKQQELVQKEESTVYSQAIHYANRM

DDENN SBF2.AA dDENN 351-420 34 5.6e-24 86.89 SMART 1-84 (84) Show / Hide
Range on Protein: 351-420
Range on HMM: 1-84/84
Sequence Identity: 34% (29 aa)

LDKEVR-AVFLRLF--AQLFQG--YRSCLQ--------LIRIHAEPVIHFHKTAFLGQRGLVE-NDFLTKVLSGMAFAGFVSER
|....| |.|||.|  .|||..  ||..|.         .|.| ||.|.|.| .||..|   .  .||....  ..|..|. ||
LNDQIREACFLRFFNYVQLFGHVDYRNYLRHHMIQQAYTWRKHPEPHITFNKESFLKSRPSHHMRPFLKMFCETQMFSQFIEER

GRAM SBF2.AA GRAM 871-957 17 2.9e-15 57.96 SMART 1-80 (80) Show / Hide
Range on Protein: 871-957
Range on HMM: 1-80/80
Sequence Identity: 17% (16 aa)

PKILRPALLPGEEIVCEG------LRVLLDPDGREEATGGLLGGPQLLPAEGALFLTTYRILFRGTPHDQLVGEQTVVRSFPIASITKEKKIT
 |. ..  || .| ..         .. |  ..              .|. | .......|.|.. . .... .|......|.|.||. .|.|
EKFRQHFKLPPNEKLINDCKKEVTYSCYLWRTY-------------DIPVQGHMYISNNHICFCSNMFGWMTCPQYYKVVIPWADITRIEKMT

SBF2.AA Myotub-related 1147-1242 20 7.9e-25 93.6 Pfam 1-121 (121) Show / Hide
Range on Protein: 1147-1242
Range on HMM: 1-121/121
Sequence Identity: 20% (26 aa)

YSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRSG----GF-HGKG-----VVGLFKSQNS---------------------P
|..|..||..||||....|. | .||......|.||.|| . ..|....|..    |. ....     .| .....|.                      
YEICPTYPAKLVVPKSISDDELKKVAKFRSWGRFPVLCWRHQENGAVICRCSQPLVGWWGWRCKEDEKLVQAIMKANADMIQSRKMYIVDARPYTNAMAN

QAAPTSSLESSSSIE-QEKYLQALLNAV
.|.        .. | .|.| .. . ..
RAKG-------GGYENEEHYPNWEFVFM

GRAM SBF2.AA GRAM 871-957 13 1.5e-09 37.25 Pfam 1-78 (78) Show / Hide
Range on Protein: 871-957
Range on HMM: 1-78/78
Sequence Identity: 13% (13 aa)

PKILRPAL--LPGEEIVCEG----LRVLLDPDGREEATGGLLGGPQLLPAEGALFLTTYRILFRGTPHDQLVGEQTVVRSFPIASITKEKKIT
.|.  .    ||..| . .      .. |  ..             ..|. |....|.... |.. . . ..   .... .|...||. .|..
EKFRKHFKDPLPPNEKLIMDCNVTYSCCLWRPF------------TKIPVQGRMYITNHHVCFYSDKFGWET---YYKMVIPWNDITRVEKMQ

Phosphatase SBF2.AA Subfamily.MTMR1.PD 1365-1498 47 2.8e-39 122.5 In-house 7-142 (149) Show / Hide
Range on Protein: 1365-1498
Range on HMM: 7-142/149
Sequence Identity: 47% (63 aa)

IPTDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVLE-NGSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSLTL-N
|.  |  .|.|| ...|. ... |.. || ... .| . .||.|   .||| |||.|||  || |..|||..||..|.|||||||||||..|      | 
ypsideskwlsaleetkwlehiklilagavriadkvesektsvvvhcsdgwdrtaqltslamllldsyyrtikgfevliekewlsfghkfaerighgdkn

CQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLK
  .  .||||||.||| || .|.|| |||| ..|  
hadadrspvflqfidcvwqvtrqfptafefneefli

Phosphatase SBF2.AA Family.Myotubularin.PD 1370-1503 47 1.9e-46 145.6 In-house 4-139 (141) Show / Hide
Range on Protein: 1370-1503
Range on HMM: 4-139/141
Sequence Identity: 47% (64 aa)

EVTFLKALGDSEWFPQLHRIMQLAVVVSEVLEN-GSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSLTLN-CQGSG
| ..|..| ...|. ... ... || . | .|. ..||||   .||| |||.|||.||| ||.|||.|||..|.|||||||||||..|   . .  . . 
ekkwlselestkWlehiklllkaavkivekvekektsvlvhcsdGWdrtaqltslaqllldpyyrtieGfevliekeWlsfGhkfaerlghgdkseseee

FAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFH
 .||||||.|||.|...|.||.||||  .|  .. |
rsPvflqfidcvyqltkqfptafefnesflikildh

Phosphatase SBF2.AA Subfamily.MTMR3.PD 1374-1503 47 2.4e-42 132.4 In-house 2-133 (135) Show / Hide
Range on Protein: 1374-1503
Range on HMM: 2-133/135
Sequence Identity: 47% (62 aa)

LKALGDSEWFPQLHRIMQLAVVVSEVLE-NGSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSLTLNCQG-SGFAPV
| || ...|. .|  ... || |.. .. .|  |||   .||| |.|...| .|| ||.|||||||..|||.|||.|||||..|.  .. .  .  .|||
lsalektkwlqhlsvllkaavkvvnavdkegrpvlvhcsdgwdrtpqivalakllldpyyrtlegfkvlverewldfghkfadrcghgedsddlnercpv

FLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFH
||.||||||...|.|| ||||  .|  |. | 
flqwldcvhqlkkqfptsfefneaflvklvqh

Phosphatase SBF2.AA Subfamily.C2-MTMR1.PD 1369-1503 40 2e-40 126.4 In-house 2-135 (137) Show / Hide
Range on Protein: 1369-1503
Range on HMM: 2-135/137
Sequence Identity: 40% (55 aa)

SEVTFLKALGDSEWFPQLHRIMQLAVVVSEVLEN-GSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSLTlNCQgSG
|.| .|  | ...|.  .. ... |  ..  .|. . | ||   .||| |.|...| ||| ||.|||..|...|.|||||.|||||.|   . ..  |  
sdvqwlsqlestqwlayikavlkaaraiarkveklavsalvhcsdgwdrtsqlvllaqllldpyyrtidglivliekewlafghkfderlgga-dsv-se

FAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFH
.|.|||||||..||. |.|. ||..  .| .|| . 
rspiflqfldclyqvtkqfpsafeytarlllklady

PH SBF2.AA PH 1744-1849 27 3.6e-21 77.58 SMART 1-82 (82) Show / Hide
Range on Protein: 1744-1849
Range on HMM: 1-82/82
Sequence Identity: 27% (29 aa)

RSFEGTLYKRGALLKGWKPRWFVLDVTKHQLRYYDSGEDTSCKGHIDLAEVEMVIPAGPSMGAPKHTSDKAFFDLKTSKRVYNFCAQDGQSAQQWMDKIQ
   ||.|||..  . .||.|||||.   ..| ||..    ..|| |.| ... .  .               | ... .|.| |.. . ...|.||. ||
VIKEGWLYKKS--K-RWKKRWFVLFN--DCLYYYKDK---KPKGSIPLSDCTVRE-P--------------CFEIHH-DRTYYFQCESEEEMQEWMQAIQ

SCISDA
..|...
KAIHNN

PH SBF2.AA PH 1744-1847 29 7.2e-18 67.08 Pfam 1-92 (92) Show / Hide
Range on Protein: 1744-1847
Range on HMM: 1-92/92
Sequence Identity: 29% (31 aa)

RSFEGTLYKRGALLKGWKPRWFVLDVTKHQLRYYDSGEDTSCKGHIDLAEVEMVIPAGPSMGAPKHTSDKAFFDLKTSKR-VYNFCAQDGQSAQQWMDKI
   || |.|.|  .|.||.|||||     .| ||...   ..|| |.| ... ...  .         ..  | ..|  | .| |.| . .....||. |
VIKEGWLHKKG-KRKSWKKRWFVLFN--NCLYYYKDDK-YRPKGSIPLSDCQVTKVPDN--------KRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAI

QSCIS
||...
QSACR

Sequence
Name Sequence Type Origin Length Description Download
SBF2.AA Protein None 1849 None Fasta, JSON
SBF2.NA RNA None 5547 None Fasta, JSON