Gene MTMR7
MTMR7
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of MTMR7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Myotub-related | MTMR7.AA | Myotub-related | 155-271 | 51 | 1.4e-70 | 245.58 | Pfam | 1-121 (121) | Show / Hide |
Range on Protein: 155-271 Range on HMM: 1-121/121 Sequence Identity: 51% (62 aa) YRVCDSYPTELYVPKSATAHIIVGSSKFRSRRRFPVLSYYYKDNHASICRSSQPLSGFS-ARCLEDEQMLQAIRKANP---GSDFVYVVDTRPKLNAMAN | .|..|| .|.||||.. . .....||||..|||||..... |.|.|||.||||.|.. .|| |||...|||.|||. .|...|.||.||..||||| YEICPTYPAKLVVPKSISDDELKKVAKFRSWGRFPVLCWRHQENGAVICRCSQPLVGWWGWRCKEDEKLVQAIMKANADMIQSRKMYIVDARPYTNAMAN RAAGKGYENEDNYSNIKFQFI ||.|.|||||..|.|..|.|. RAKGGGYENEEHYPNWEFVFM |
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| Phosphatase | MTMR7.AA | Family.Myotubularin.PD | 299-432 | 58 | 1.7e-60 | 192.6 | In-house | 6-141 (141) | Show / Hide |
Range on Protein: 299-432 Range on HMM: 6-141/141 Sequence Identity: 58% (80 aa) DFLWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNLDGD--PKEIS ..| ||.. ||.|||....| . |...|..|. |||||||||||||||..|.|.|||||.|||..|| |||||.|.||||||..|.|. | .| | kwlselestkWlehiklllkaavkivekvekektsvlvhcsdGWdrtaqltslaqllldpyyrtieGfevliekeWlsfGhkfaerlghgdkseseeers PVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHIY ||. |||.||.||..|||.||||||.|||.| .|.| Pvflqfidcvyqltkqfptafefnesflikildhly |
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| Phosphatase | MTMR7.AA | Subfamily.MTMR1.PD | 298-432 | 59 | 4.3e-56 | 178.7 | In-house | 13-149 (149) | Show / Hide |
Range on Protein: 298-432 Range on HMM: 13-149/149 Sequence Identity: 59% (80 aa) SDFLWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNLDGD--PKEI | .| ||.. || ||| |.. . ||..|..| .||.||||||||||||. |.| ||||..|||.||| |||||.|.||||||..|.|| . .. || skwlsaleetkwlehiklilagavriadkvesektsvvvhcsdgwdrtaqltslamllldsyyrtikgfevliekewlsfghkfaerighgdknhadadr SPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHIY |. |||.||||...|||.||||||.||| | |.| spvflqfidcvwqvtrqfptafefneeflitildhly |
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| Phosphatase | MTMR7.AA | Subfamily.C2-MTMR1.PD | 300-430 | 49 | 3e-52 | 166.2 | In-house | 6-135 (137) | Show / Hide |
Range on Protein: 300-430 Range on HMM: 6-135/137 Sequence Identity: 49% (64 aa) FLWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNLDGdPKEISPVI .| ||...|| .|||...| ||. | . . | |||||||||||.|. ..| |||||.|||..|..|||||.|..|||||..|.|.| . | ||.. wlsqlestqwlayikavlkaaraiarkveklavsalvhcsdgwdrtsqlvllaqllldpyyrtidglivliekewlafghkfderlggads-vserspif DQFIECVWQLMEQFPCAFEFNERFLIHIQHH ||..|..|. |||.|||.. |.|... . lqfldclyqvtkqfpsafeytarlllklady |
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| Phosphatase | MTMR7.AA | Subfamily.MTMR3.PD | 303-432 | 51 | 1e-50 | 161.1 | In-house | 4-135 (135) | Show / Hide |
Range on Protein: 303-432 Range on HMM: 4-135/135 Sequence Identity: 51% (67 aa) GLENSGWLRHIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNLDG--DPKEISPVID ||.. ||.|. ....| . ...|| .|| ||||||||||||.|. ..| |||||.||||.|| ||.|..|..||||| | |. . |.| .||. |. alektkwlqhlsvllkaavkvvnavdkegrpvlvhcsdgwdrtpqivalakllldpyyrtlegfkvlverewldfghkfadrcghgedsddlnercpvfl QFIECVWQLMEQFPCAFEFNERFLIHIQHHIY ..||.|| .|||..||||| ||... .| | qwldcvhqlkkqfptsfefneaflvklvqhty |
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| Phosphatase | MTMR7.AA | PTPc_motif | 264-432 | 8 | 3.8e-08 | 34.31 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 264-432
Range on HMM: 1-92/92
Sequence Identity: 8% (14 aa)
SNIKFQFIGIENI-----HVMRNSLQKMLEVCELKSPSMSDFLWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDP
. ... . . .| .|. .... .. ...||||.|..||...|.. ... .
TVHHYHYTNWPDHVEKDSGVPEDSILEFIRHVRK----------------------------------------PIVVHCSAGCGRTGTFCAIDMMMQQ-
HYRTLKGFMVLIEKDWISFGHKFNHRYGNLDGDPKEISPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHIY
. . ..|.....| | ... .| .. .. ...
-----------------------------------------VDIFQTVKEMRKQRPGMVQTEEQYIFCYRCILE
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| Phosphatase | MTMR7.AA | Subfamily.DSP3.PD | 318-361 | 36 | 3.4e-07 | 19.9 | In-house | 76-118 (148) | Show / Hide |
Range on Protein: 318-361 Range on HMM: 76-118/148 Sequence Identity: 36% (15 aa) DAGIFIAKAVSEEGASVLVHCSDGWDRTAQvCSVASLLLDPHYR | ||..|.|.... ||||| | |.| . .| |.. . eaadfidealsqkngkvlvhcvvGisRsat-lvlayLmirrklt |
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| Phosphatase | MTMR7.AA | Subfamily.N_Fungi_PTP1.PD | 243-357 | 22 | 7.6e-06 | 14.7 | In-house | 180-286 (343) | Show / Hide |
Range on Protein: 243-357 Range on HMM: 180-286/343 Sequence Identity: 22% (24 aa) PKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCELKSPSmsDFLWGLEnsgwlrHIKAIMDAGIFIAKAVSEEGASVLVHCSDGW | .| | . .....| ... . . | |.. ... ... | | ..| || . ..| ........||||| | || .. vkkeasdndnksddndlnnnndltpvtaavsepyevyqlqvknWkDlslllnPe--silqale------vkndliddlfaeshldnarsspilvhCsaGv DRTAQVCSVASLLLD .. ||| | GrtGtlvtlDsllsd |
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