• Phosphatome.Net

Gene CDC25B

CDC25B
Species: Human
Alias: CDC25B
External Links: COSMIC , Entrez Gene
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-II
Family: CDC25
Subfamily: CDC25
Protein domain

Protein domains of CDC25B.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
M-inducer_phosp CDC25B.AA M-inducer_phosp 113-384 48 8e-167 565.3 Pfam 1-302 (302) Show / Hide 
Range on Protein: 113-384
Range on HMM: 1-302/302
Sequence Identity: 48% (146 aa)

MDSPSPMDPHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEAGSGAASSSGEDKENDGFVFKMPWKPTHPSSTH
||||..||..|.|.||.|.....|..|...|..|||..|||..||..||.......||..|......|...|..||.|.|||.||.||||.||.|....|
MDSPGHMDSQMNEETFQQFTPDRSWVIQHMQCPIRRMMSMPQHLLCCSPAFKRCSHSQSLDHWGHHKADYFAMCSSDENKENEGFQFKMPCKPHHRGCFH

ALAEWASRREAFAQRPSSAPDLMCLSPDRKMEV---EELSPLALGRFSL--TPAEGDT----EED------DGFVDILESD-LKDDDAVPPG--------
|..||...||.|.||..||||.||.||||||||   ||.....||....  ||...|.    .||      |||||.|... ||||...|.|        
AHLEWWEHRELFTQRQNSAPDCMCSSPDRKMEVSLEEECEMVHLGSPISADTPCKTDCNPNRHEDIKMQNLDGFVDMLDGENLKDDMMEPCGAVGNLSCS

MESLISAPLVKTLEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQQ--EAEEPKARV---LRSK-SLCHDEIE
|.||..||||..|...||||..||..||||.|||||.|...||.|||.|||.|.||||..|||.|...|..|.  |...||.||   .||| ||||..||
MASLWTAPLVMKLTEQEEKDNIMYNRCQRLYRSPSMCCCLTRPMLKRVERPHDHDTPVKVKRRKSMSHPVQQKLRENCCPKKRVHQSMRSKLSLCHQTIE

NL
|.
NM
Rhodanese CDC25B.AA RHOD 421-535 31 8.3e-30 106.26 SMART 1-94 (94) Show / Hide 
Range on Protein: 421-535
Range on HMM: 1-94/94
Sequence Identity: 31% (37 aa)

VALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERG-PRMCRFIRERDRAVNDYPSLYYPEM
| .. .|.    ...||.|||.|||||||||. |.|.|..   ..         ...||. ..|..| .|..|. ||.... || ..           ..
V-PEWWKMLQN-EDCVIIDCRWPYEYEGGHIPGAINIPWDELLDR---------LGIDKDKPVIVYC-RSGNRSAPRAAWWLREAGYK----------NV

YILKGGYKEFFPQHPN
|||.||.||.. ..| 
YILDGGWKEWKRACPP
Phosphatase CDC25B.AA Family.CDC25.PD 423-534 56 1.5e-47 148.3 In-house 3-116 (117) Show / Hide 
Range on Protein: 423-534
Range on HMM: 3-116/117
Sequence Identity: 56% (64 aa)

LLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVN--DYPSLYYPEMY
||.|.... ..|..|.||||||||||||||.||||  ....|...||.| ...| .||.|.||||||||||||...|..||.|| .|  .||.|.|||.|
llkgetkeliekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvkaseekrtivifhCefSseRgPklarllrevdrelnkeeypkleypely

ILKGGYKEFFPQHP
.|.||||||| ...
lLegGykeffeeve
Phosphatase CDC25B.AA Group.Cx5R-II.PD 423-534 56 1.5e-47 148.3 In-house 3-116 (117) Show / Hide 
Range on Protein: 423-534
Range on HMM: 3-116/117
Sequence Identity: 56% (64 aa)

LLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVN--DYPSLYYPEMY
||.|.... ..|..|.||||||||||||||.||||  ....|...||.| ...| .||.|.||||||||||||...|..||.|| .|  .||.|.|||.|
llkgetkeliekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvkaseekrtivifhCefSseRgPklarllrevdrelnkeeypkleypely

ILKGGYKEFFPQHP
.|.||||||| ...
lLegGykeffeeve
Phosphatase CDC25B.AA Subfamily.CDC25.PD 423-534 56 1.5e-47 148.3 In-house 3-116 (117) Show / Hide 
Range on Protein: 423-534
Range on HMM: 3-116/117
Sequence Identity: 56% (64 aa)

LLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVN--DYPSLYYPEMY
||.|.... ..|..|.||||||||||||||.||||  ....|...||.| ...| .||.|.||||||||||||...|..||.|| .|  .||.|.|||.|
llkgetkeliekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvkaseekrtivifhCefSseRgPklarllrevdrelnkeeypkleypely

ILKGGYKEFFPQHP
.|.||||||| ...
lLegGykeffeeve
Phosphatase CDC25B.AA Rhodanese 424-532 23 5.7e-20 64.99 Pfam 1-102 (102) Show / Hide 
Range on Protein: 424-532
Range on HMM: 1-102/102
Sequence Identity: 23% (27 aa)

LTGKFSNIV--DKFVIVDCRYPYEYEGGHIKTA-VNLPLERDAESFL--LKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPE
.   . ..   ...||.|.| |.|||.|||. | ||.|.       .  |.  ..  . ||.. ....|  .. |.  .... ..   . . ||    |.
TPEWLKEMMNDPDYVIIDVRPPEEYEKGHIPGAHVNIPW----LEEEHDLEELGIKLDKDKPI-IVVYC--HGNRSG-AWACLVWWMLKAMGYP----PN

MYILKGGYKEFFPQ
 |.|.||....  .
VYVLDGGWEAWKAE
Sequence
Name Sequence Type Origin Length Description Download
CDC25B.AA Protein None 580 None Fasta, JSON
CDC25B.NA RNA None 1740 None Fasta, JSON
CDC25B.AA.PD_421-535 Protein Phosphatase Domain None 115 None Fasta, JSON