• Phosphatome.Net

Gene CDC25C

CDC25C
Species: Human
Alias: CDC25C, CDC25
External Links: COSMIC , Entrez Gene
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-II
Family: CDC25
Subfamily: CDC25
Protein domain

Protein domains of CDC25C.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
M-inducer_phosp CDC25C.AA M-inducer_phosp 93-155 36 1.3e-27 100.4 Pfam 1-84 (302) Show / Hide 
Range on Protein: 93-155
Range on HMM: 1-84/302
Sequence Identity: 36% (31 aa)

LDETGHLDSSGLQE-----------------VHLAG-MNHDQHLMKCSPAQLLCSTPNGLDR-GHRKRD--AMCSSSANKENDN
.|..||.||.. .|                 ..... |...|||..||||...||....||. ||.|.|  |||||..||||..
MDSPGHMDSQMNEETFQQFTPDRSWVIQHMQCPIRRMMSMPQHLLCCSPAFKRCSHSQSLDHWGHHKADYFAMCSSDENKENEG
M-inducer_phosp CDC25C.AA M-inducer_phosp 156-272 32 4.5e-54 190.76 Pfam 131-302 (302) Show / Hide 
Range on Protein: 156-272
Range on HMM: 131-302/302
Sequence Identity: 32% (56 aa)

GNL---VDSEMKYLGSPIT--TVPKLDKNPNLGED-------------QAEEISDELMEFS---------------------LKDQEAK----VSRS-GL
...   ...||..|||||.  |..|.|.|||..||             ..|...|..||..                     |..||.|    ..|. .|
MEVSLEEECEMVHLGSPISADTPCKTDCNPNRHEDIKMQNLDGFVDMLDGENLKDDMMEPCGAVGNLSCSMASLWTAPLVMKLTEQEEKDNIMYNRCQRL

YRSPSMPENLNRPRLKQVEKFKDNTIPDKVKKKYFSGQ---GKLRKGLCLKKTV--------SLCDITITQM
||||||...|.||.||.||...|...|.|||.......   .|||...|.||.|        |||..||..|
YRSPSMCCCLTRPMLKRVERPHDHDTPVKVKRRKSMSHPVQQKLRENCCPKKRVHQSMRSKLSLCHQTIENM
Rhodanese CDC25C.AA RHOD 311-425 29 7.4e-20 73.22 SMART 1-94 (94) Show / Hide 
Range on Protein: 311-425
Range on HMM: 1-94/94
Sequence Identity: 29% (34 aa)

AALLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFFLKKPIVPLDTQKRIIIVFHCEFSSERG-PRMCRCLREEDRSLNQYPALYYPEL
. .. .|.    |.. .||||.|||| |||| ||.|.   | |           |.  |. .....| .|..|. ||... ||| ...          . 
V-PEWWKMLQN-EDCVIIDCRWPYEYEGGHIPGAINIPWDELLDR---------LGIDKDKPVIVYC-RSGNRSAPRAAWWLREAGYK----------NV

YILKGGYRDFFPEYME
|||.||.. .. .. .
YILDGGWKEWKRACPP
Phosphatase CDC25C.AA Family.CDC25.PD 313-424 62 6.5e-50 155.9 In-house 3-116 (117) Show / Hide 
Range on Protein: 313-424
Range on HMM: 3-116/117
Sequence Identity: 62% (71 aa)

LLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFFLKKPIVPLDTQKRIIIVFHCEFSSERGPRMCRCLREEDRSLN--QYPALYYPELY
||.|... ||||...||||||||| ||||.||.||||.||| ..|||.| |. ...|| |..|||||||||||...|.||| ||.||  .||.|.|||||
llkgetkeliekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvkaseekrtivifhCefSseRgPklarllrevdrelnkeeypkleypely

ILKGGYRDFFPEYM
.|.|||..|| |. 
lLegGykeffeeve
Phosphatase CDC25C.AA Group.Cx5R-II.PD 313-424 62 6.5e-50 155.9 In-house 3-116 (117) Show / Hide 
Range on Protein: 313-424
Range on HMM: 3-116/117
Sequence Identity: 62% (71 aa)

LLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFFLKKPIVPLDTQKRIIIVFHCEFSSERGPRMCRCLREEDRSLN--QYPALYYPELY
||.|... ||||...||||||||| ||||.||.||||.||| ..|||.| |. ...|| |..|||||||||||...|.||| ||.||  .||.|.|||||
llkgetkeliekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvkaseekrtivifhCefSseRgPklarllrevdrelnkeeypkleypely

ILKGGYRDFFPEYM
.|.|||..|| |. 
lLegGykeffeeve
Phosphatase CDC25C.AA Subfamily.CDC25.PD 313-424 62 6.5e-50 155.9 In-house 3-116 (117) Show / Hide 
Range on Protein: 313-424
Range on HMM: 3-116/117
Sequence Identity: 62% (71 aa)

LLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFFLKKPIVPLDTQKRIIIVFHCEFSSERGPRMCRCLREEDRSLN--QYPALYYPELY
||.|... ||||...||||||||| ||||.||.||||.||| ..|||.| |. ...|| |..|||||||||||...|.||| ||.||  .||.|.|||||
llkgetkeliekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvkaseekrtivifhCefSseRgPklarllrevdrelnkeeypkleypely

ILKGGYRDFFPEYM
.|.|||..|| |. 
lLegGykeffeeve
Phosphatase CDC25C.AA Rhodanese 314-422 27 1.3e-17 57.55 Pfam 1-102 (102) Show / Hide 
Range on Protein: 314-422
Range on HMM: 1-102/102
Sequence Identity: 27% (31 aa)

LSGKFQGLI--EKFYVIDCRYPYEYLGGHIQGA-LNLYSQEELFNFF--LKKPIVPLDTQKRIIIVFHCEFSSERGPRMCRCLREEDRSLNQYPALYYPE
.   .. ..  ... .||.| |.|| .||| || .|.      .     |.. .. ||  |.| ||..|  .. |.  ...||..     . ||    |.
TPEWLKEMMNDPDYVIIDVRPPEEYEKGHIPGAHVNIPW----LEEEHDLEELGIKLDKDKPI-IVVYC--HGNRSG-AWACLVWWMLKAMGYP----PN

LYILKGGYRDFFPE
 |.|.||. ..  |
VYVLDGGWEAWKAE
Sequence
Name Sequence Type Origin Length Description Download
CDC25C.AA Protein None 473 None Fasta, JSON
CDC25C.NA RNA None 1419 None Fasta, JSON
CDC25C.AA.PD_311-425 Protein Phosphatase Domain None 115 None Fasta, JSON