• Phosphatome.Net

Gene CDC25A

CDC25A
Species: Human
Alias: CDC25A2, CDC25A
External Links: COSMIC , Entrez Gene
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-II
Family: CDC25
Subfamily: CDC25
Protein domain

Protein domains of CDC25A.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
M-inducer_phosp CDC25A.AA M-inducer_phosp 86-329 42 2.5e-138 470.66 Pfam 1-302 (302) Show / Hide 
Range on Protein: 86-329
Range on HMM: 1-302/302
Sequence Identity: 42% (129 aa)

LDSPGPLDSKENLE-----------------NPMRRIHSLPQKLLGCSPALKR-SHSDSLDH------DIFQLIDPDENKENEAFEFKKPVRPVSRGCLH
.||||..||..|.|                 .|.||..|.||.||.||||.|| |||.||||      |.|.....|||||||.|.||.|..|..|||.|
MDSPGHMDSQMNEETFQQFTPDRSWVIQHMQCPIRRMMSMPQHLLCCSPAFKRCSHSQSLDHWGHHKADYFAMCSSDENKENEGFQFKMPCKPHHRGCFH

SHG-LQEGKDLFTQRQNSAPARMLSSN-ERDSS---EPGNFIPLFTPQS--PVTATLS----DED------DGFVDLLDGENLKNEEETPSC--------
.|. ..|...||||||||||..|.||. .....   |......|..|.|  ....|..    .||      |||||.|||||||.....|..        
AHLEWWEHRELFTQRQNSAPDCMCSSPDRKMEVSLEEECEMVHLGSPISADTPCKTDCNPNRHEDIKMQNLDGFVDMLDGENLKDDMMEPCGAVGNLSCS

MASLWTAPLVMRTTN-------LDNRC-KLFDSPSLCSSSTRSVLKRPERSQEESPPGSTKRRKSMSG-ASPK--ESTNPEKAHETLHQSLSLA-SSPKG
|||||||||||..|.       ..||| .|..|||.|...||..|||.||......|...|||||||. ...|  |...|.|   ..|||.... |....
MASLWTAPLVMKLTEQEEKDNIMYNRCQRLYRSPSMCCCLTRPMLKRVERPHDHDTPVKVKRRKSMSHPVQQKLRENCCPKK---RVHQSMRSKLSLCHQ

TIENI
||||.
TIENM
Rhodanese CDC25A.AA RHOD 366-479 31 2.1e-28 101.59 SMART 1-94 (94) Show / Hide 
Range on Protein: 366-479
Range on HMM: 1-94/94
Sequence Identity: 31% (36 aa)

ASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPTDGKRVIVVFHCEFSSERG-PRMCRYVRERDRLGNEYPKLHYPELY
. .. .|..   ...||||||.|||||||||.||.|....| ...           .|. .|...| .|..|. ||.... || ..           . |
V-PEWWKMLQN-EDCVIIDCRWPYEYEGGHIPGAINIPWDELLDR--------LGIDKDKPVIVYC-RSGNRSAPRAAWWLREAGYK----------NVY

VLKGGYKEFFMKCQS
.|.||.||.. .|  
ILDGGWKEWKRACPP
Phosphatase CDC25A.AA Family.CDC25.PD 367-478 61 1.2e-49 155.1 In-house 2-116 (117) Show / Hide 
Range on Protein: 367-478
Range on HMM: 2-116/117
Sequence Identity: 61% (71 aa)

SVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVP-TDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGN--EYPKLHYPEL
..|.|....||....|||||||||||||||||||||...||.|...||.| |. .. ||.||.|||||||||||...|..||.||  |  |||||.||||
allkgetkeliekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvkaseekrtivifhCefSseRgPklarllrevdrelnkeeypkleypel

YVLKGGYKEFFMKCQ
|.|.||||||| ...
ylLegGykeffeeve
Phosphatase CDC25A.AA Group.Cx5R-II.PD 367-478 61 1.2e-49 155.1 In-house 2-116 (117) Show / Hide 
Range on Protein: 367-478
Range on HMM: 2-116/117
Sequence Identity: 61% (71 aa)

SVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVP-TDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGN--EYPKLHYPEL
..|.|....||....|||||||||||||||||||||...||.|...||.| |. .. ||.||.|||||||||||...|..||.||  |  |||||.||||
allkgetkeliekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvkaseekrtivifhCefSseRgPklarllrevdrelnkeeypkleypel

YVLKGGYKEFFMKCQ
|.|.||||||| ...
ylLegGykeffeeve
Phosphatase CDC25A.AA Subfamily.CDC25.PD 367-478 61 1.2e-49 155.1 In-house 2-116 (117) Show / Hide 
Range on Protein: 367-478
Range on HMM: 2-116/117
Sequence Identity: 61% (71 aa)

SVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVP-TDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGN--EYPKLHYPEL
..|.|....||....|||||||||||||||||||||...||.|...||.| |. .. ||.||.|||||||||||...|..||.||  |  |||||.||||
allkgetkeliekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvkaseekrtivifhCefSseRgPklarllrevdrelnkeeypkleypel

YVLKGGYKEFFMKCQ
|.|.||||||| ...
ylLegGykeffeeve
Phosphatase CDC25A.AA Rhodanese 369-476 27 3.9e-22 71.86 Pfam 1-102 (102) Show / Hide 
Range on Protein: 369-476
Range on HMM: 1-102/102
Sequence Identity: 27% (31 aa)

LNGKFANLI--KEFVIIDCRYPYEYEGGHIKGA-VNLHMEEEVEDF--LLKKPIVPTDGKRVIVVFHCEFSSERGPRMCRYVRER-DRLGNEYPKLHYPE
.   .....  ...||||.| |.|||.|||.|| ||.      |.   | .  | . ..|.. .|..|  .. |.  ... ...   .  . ||    |.
TPEWLKEMMNDPDYVIIDVRPPEEYEKGHIPGAHVNIPW---LEEEHDLEELGIKLDKDKPI-IVVYC--HGNRSG-AWACLVWWMLKA-MGYP----PN

LYVLKGGYKEFFMK
 |||.||.... ..
VYVLDGGWEAWKAE
Sequence
Name Sequence Type Origin Length Description Download
CDC25A.AA Protein None 524 None Fasta, JSON
CDC25A.NA RNA None 1572 None Fasta, JSON
CDC25A.AA.PD_366-479 Protein Phosphatase Domain None 114 None Fasta, JSON