• Phosphatome.Net

Gene EYA1

EYA1
Species: Human
Alias: BOP, BOR, EYA1, MGC141875
External Links: COSMIC , Entrez Gene
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: HAD
Family: EYA
Subfamily: EYA
Protein domain

Protein domains of EYA1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase EYA1.AA Family.EYA.PD 322-567 89 6.6e-159 514.3 In-house 1-246 (247) Show / Hide 
Range on Protein: 322-567
Range on HMM: 1-246/247
Sequence Identity: 89% (220 aa)

ERVFIWDLDETIIVFHSLLTGSYANRYGRDPPTSVSLGLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYNFGTDGFPAAATSANLCLA
||||.||||||||.||||||||||..||.|...||.||||||||||||||||||||||||||||||||||||||||||||||| |||| |||||||||||
ervfvwdldetiiifhslltgsyaekygkdasssvalglrmeemifnladthlffndleecdqvhiddvssddngqdlstynfatdgfhaaatsanlcla

TGVRGGVDWMRKLAFRYRRVKEIYNTYKNNVGGLLGPAKREAWLQLRAEIEALTDSWLTLALKALSLIHSRTNCVNILVTTTQLIPALAKVLLYGLGIVF
||||||||||||||||||.||||||.||||||||||||||||||||||||||||||||||||||||||.||.||||.|||||||.|||||||||||| ||
tgvrggvdwmrklafryrkvkeiynsyknnvggllgpakreawlqlraeiealtdswltlalkalslissrsncvnvlvtttqlvpalakvllyglggvf

PIENIYSATKIGKESCFERIIQRFGRKVVYVVIGDGVEEEQGAKKH
||||||||||||||||||||..||||||.|||||||..||..|||.
pieniysatkigkescferivarfgrkvtyvvigdgkdeetaakkl
Phosphatase EYA1.AA Subfamily.EYA.PD 322-567 89 6.6e-159 514.3 In-house 1-246 (247) Show / Hide 
Range on Protein: 322-567
Range on HMM: 1-246/247
Sequence Identity: 89% (220 aa)

ERVFIWDLDETIIVFHSLLTGSYANRYGRDPPTSVSLGLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYNFGTDGFPAAATSANLCLA
||||.||||||||.||||||||||..||.|...||.||||||||||||||||||||||||||||||||||||||||||||||| |||| |||||||||||
ervfvwdldetiiifhslltgsyaekygkdasssvalglrmeemifnladthlffndleecdqvhiddvssddngqdlstynfatdgfhaaatsanlcla

TGVRGGVDWMRKLAFRYRRVKEIYNTYKNNVGGLLGPAKREAWLQLRAEIEALTDSWLTLALKALSLIHSRTNCVNILVTTTQLIPALAKVLLYGLGIVF
||||||||||||||||||.||||||.||||||||||||||||||||||||||||||||||||||||||.||.||||.|||||||.|||||||||||| ||
tgvrggvdwmrklafryrkvkeiynsyknnvggllgpakreawlqlraeiealtdswltlalkalslissrsncvnvlvtttqlvpalakvllyglggvf

PIENIYSATKIGKESCFERIIQRFGRKVVYVVIGDGVEEEQGAKKH
||||||||||||||||||||..||||||.|||||||..||..|||.
pieniysatkigkescferivarfgrkvtyvvigdgkdeetaakkl
Phosphatase EYA1.AA Group.HAD.PD 323-549 20 1.3e-38 120.8 In-house 2-189 (190) Show / Hide 
Range on Protein: 323-549
Range on HMM: 2-189/190
Sequence Identity: 20% (44 aa)

RVFIWDLDETIIvfhslLTGSYANRYGRDPPTSVSLGLRMeemifNLADTHLFFNDLEECDQVHIDDVSsddngqdlstynFGTDGFPAAA---------
.....|||....     |.||.....| . ...| ..|..     | ....|.... ..........|.            ...|.| ...|... . |.
dtlvlDldgvlw-----lhgspepleglrskgkvlifltn-----natksrlyllkrlallgflveeve------------phldeflervgelyelvvf

TSANLCLATGVRGGVDWMrKLAFRYRRVKEIYNTYKNnVGGLLGPAKReawlqlraeiealTDSWLTLALKALSLIHSRTNCVNILVtttqlipALAKVL
 |.|.||.. ..||.||.... .. .|. .|.||....|             ....|. .|.... |. . ........ ...|..|      |..|..|
tagtreyadpvvgavdvg-deafsyrklrdacvylkg-pgalllatnr-------------dlgalvrdlekvviidnkpsvfafec-------npenal

LYGLGivfpIENIYSATKIGKESCFERIIQRFGRKV
...|.....|.| .|||..|                
migdf----iddildaellglipdlenidvrfgkdv
Phosphatase EYA1.AA Hydrolase 322-568 10 1e-11 41.56 Pfam 1-167 (167) Show / Hide 
Range on Protein: 322-568
Range on HMM: 1-167/167
Sequence Identity: 10% (28 aa)

ERVFIWDLDETIIVF----HSLLTGSYANRYGRDPPTSVSLGLRMEEMIF-NLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYNFGTDGFPAAATSA
 .....|.| |.. .    |   . . | .||  .|  .   .  ... . . .|..  . ..                                     
IKAVVFDKDGTLTDGSEHPHAQAWVEAAREYGY-WPFEEVEYIWGRGI-GDRIIDWWRATDEHI------------------------------------

NLCLATGVRGGVDWMRKLAFRYRRVKEIYNTYKNNVGGLLGPAKREAWLQLRAEIEALTDSWLTLALKALSLIHSRTNCVNILVTTTQLIPALAKVLLYG
                                                   . ...|. | ..  | .||  .... ..  ...| .   .| |.. ..|
------------------------------------------------D-EYLGVIAD-DQPYPGAREALQALKRM-GIKVAMITNDNR-NAQAVLEHLG

LGIVFPIENIYSATKI---GKESCFERIIQRFGRKVV---YVVIGDGVEEEQGAKKHA
..  | .  ... ..|    .  ..|...||.| |..   ....|||.   . .... 
IA-YFDHIIDSDDVGIVGKPHPEMYEKACQRLGVKPHECGCMMVGDGINDDPMLAQAG
Sequence
Name Sequence Type Origin Length Description Download
EYA1.AA Protein None 592 None Fasta, JSON
EYA1.NA RNA None 1776 None Fasta, JSON
EYA1.AA.PD_322-568 Protein Phosphatase Domain None 247 None Fasta, JSON