• Phosphatome.Net

Gene EYA2

EYA2
Species: Human
Alias: EAB1, MGC10614, EYA2
External Links: COSMIC , Entrez Gene
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: HAD
Family: EYA
Subfamily: EYA
Protein domain

Protein domains of EYA2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase EYA2.AA Family.EYA.PD 268-514 80 2.8e-154 499.1 In-house 1-247 (247) Show / Hide 
Range on Protein: 268-514
Range on HMM: 1-247/247
Sequence Identity: 80% (199 aa)

ERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLG
|||||||||||||||||||||..|..||||...||..||.|||||||||||||||||||.|||.|.|||||||||||||||||..||||..|..|||||.
ervfvwdldetiiifhslltgsyaekygkdasssvalglrmeemifnladthlffndleecdqvhiddvssddngqdlstynfatdgfhaaatsanlcla

SGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGTPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVF
.||.||||||||||||||.|||.||.||||||||.|. |||.|||||||.||||| |||..||||.||.|| ||||||||||||.||||||||||||.||
tgvrggvdwmrklafryrkvkeiynsyknnvggllgpakreawlqlraeiealtdswltlalkalslissrsncvnvlvtttqlvpalakvllyglggvf

PIENIYSATKTGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHN
||||||||||.|||||||||..|||||..|||||||..||..|||.|
pieniysatkigkescferivarfgrkvtyvvigdgkdeetaakkln
Phosphatase EYA2.AA Subfamily.EYA.PD 268-514 80 2.8e-154 499.1 In-house 1-247 (247) Show / Hide 
Range on Protein: 268-514
Range on HMM: 1-247/247
Sequence Identity: 80% (199 aa)

ERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLG
|||||||||||||||||||||..|..||||...||..||.|||||||||||||||||||.|||.|.|||||||||||||||||..||||..|..|||||.
ervfvwdldetiiifhslltgsyaekygkdasssvalglrmeemifnladthlffndleecdqvhiddvssddngqdlstynfatdgfhaaatsanlcla

SGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGTPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVF
.||.||||||||||||||.|||.||.||||||||.|. |||.|||||||.||||| |||..||||.||.|| ||||||||||||.||||||||||||.||
tgvrggvdwmrklafryrkvkeiynsyknnvggllgpakreawlqlraeiealtdswltlalkalslissrsncvnvlvtttqlvpalakvllyglggvf

PIENIYSATKTGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHN
||||||||||.|||||||||..|||||..|||||||..||..|||.|
pieniysatkigkescferivarfgrkvtyvvigdgkdeetaakkln
Phosphatase EYA2.AA Group.HAD.PD 269-494 19 6.1e-36 112.1 In-house 2-188 (190) Show / Hide 
Range on Protein: 269-494
Range on HMM: 2-188/190
Sequence Identity: 19% (43 aa)

RVFVWDLDETIIifhslLTGTFASRYGKDTTTSVRIGLMMeemifNLADTHLFFNDLEDCDQIHVDDVSsddngqdlstynFSADGFHSSA---------
...|.|||....     |.|... ..|..  ..|.|.|..     | ....|.... . .....|..|.            . .|.|. ...... .  .
dtlvlDldgvlw-----lhgspepleglrskgkvlifltn-----natksrlyllkrlallgflveeve------------phldeflervgelyelvvf

PGANLCLGSGVHGGVDWMrKLAFRYRRVKEMYNTYKNnVGGLIGTPKRetwlqlraelealTDLWLTHSLKALNLINSRPNCVNVLVtttqlipALAKVL
 | |.||.. ..||.||.... .. .|. .|.|.....|             .. .|.  |...  |  .|........ ...|..|      |..|..|
tagtreyadpvvgavdvg-deafsyrklrdacvylkg-pgalllatnr-------------dlgalvrdlekvviidnkpsvfafec-------npenal

LYGLGsvfpIENIYSATKTGKESCFERIMQRFGRK
...|.....|.|..|||..                
migdf----iddildaellglipdlenidvrfgkd
Phosphatase EYA2.AA Hydrolase 268-514 10 2.5e-12 43.7 Pfam 1-167 (167) Show / Hide 
Range on Protein: 268-514
Range on HMM: 1-167/167
Sequence Identity: 10% (26 aa)

ERVFVWDLDETIIIF----HSLLTGTFASRYGKDTTTSVRIGLMMEEMIF-NLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGA
 ...|.|.| |.. .    |   .  .| .||. ..  .   .. ... . . .|..  . ..                                     
IKAVVFDKDGTLTDGSEHPHAQAWVEAAREYGY-WPFEEVEYIWGRGI-GDRIIDWWRATDEHI------------------------------------

NLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGTPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYG
                                                   . ...|. | .. .. .||. .... ..  ...| .   .| |.. ..|
------------------------------------------------D-EYLGVIAD-DQPYPGAREALQALKRM-GIKVAMITNDNR-NAQAVLEHLG

LGSVFPIENIYSATK---TGKESCFERIMQRFGRKAV---YVVIGDGVEEEQGAKKHN
..  | .  ... ..     .  ..|...||.| | .   ....|||.   . .....
IA-YFDHIIDSDDVGIVGKPHPEMYEKACQRLGVKPHECGCMMVGDGINDDPMLAQAG
Sequence
Name Sequence Type Origin Length Description Download
EYA2.AA Protein None 538 None Fasta, JSON
EYA2.NA RNA None 1614 None Fasta, JSON
EYA2.AA.PD_268-514 Protein Phosphatase Domain None 247 None Fasta, JSON