EYA3
Species: Human
Alias: DKFZp686C132, EYA3
External Links: COSMIC , Entrez Gene
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: HAD
Family: EYA
Subfamily: EYA
Protein domain

Protein domains of EYA3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase EYA3.AA Family.EYA.PD 303-549 76 4.6e-149 482.0 In-house 1-247 (247) Show / Hide
Range on Protein: 303-549
Range on HMM: 1-247/247
Sequence Identity: 76% (188 aa)

ERVFLWDLDETIIIFHSLLTGSYAQKYGKDPTVVIGSGLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGSS
||||.|||||||||||||||||||.|||||.....  ||.||||||..|||||||||||||||||..||.|||||||||.|.|.||||.....|......
ervfvwdldetiiifhslltgsyaekygkdasssvalglrmeemifnladthlffndleecdqvhiddvssddngqdlstynfatdgfhaaatsanlcla

VGVQGGVDWMRKLAFRYRKVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALKSLLLIQSRKNCVNVLITTTQLVPALAKVLLYGLGEIF
.||.||||||||||||||||.|||...|.||||||.|...||...||||||.||||||..|||.| ||.||.||||||.||||||||||||||||||..|
tgvrggvdwmrklafryrkvkeiynsyknnvggllgpakreawlqlraeiealtdswltlalkalslissrsncvnvlvtttqlvpalakvllyglggvf

PIENIYSATKIGKESCFERIVSRFGKKVTYVVIGDGRDEEIAAKQHN
|||||||||||||||||||||.|||.||||||||||.|||.|||..|
pieniysatkigkescferivarfgrkvtyvvigdgkdeetaakkln

Phosphatase EYA3.AA Subfamily.EYA.PD 303-549 76 4.6e-149 482.0 In-house 1-247 (247) Show / Hide
Range on Protein: 303-549
Range on HMM: 1-247/247
Sequence Identity: 76% (188 aa)

ERVFLWDLDETIIIFHSLLTGSYAQKYGKDPTVVIGSGLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGSS
||||.|||||||||||||||||||.|||||.....  ||.||||||..|||||||||||||||||..||.|||||||||.|.|.||||.....|......
ervfvwdldetiiifhslltgsyaekygkdasssvalglrmeemifnladthlffndleecdqvhiddvssddngqdlstynfatdgfhaaatsanlcla

VGVQGGVDWMRKLAFRYRKVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALKSLLLIQSRKNCVNVLITTTQLVPALAKVLLYGLGEIF
.||.||||||||||||||||.|||...|.||||||.|...||...||||||.||||||..|||.| ||.||.||||||.||||||||||||||||||..|
tgvrggvdwmrklafryrkvkeiynsyknnvggllgpakreawlqlraeiealtdswltlalkalslissrsncvnvlvtttqlvpalakvllyglggvf

PIENIYSATKIGKESCFERIVSRFGKKVTYVVIGDGRDEEIAAKQHN
|||||||||||||||||||||.|||.||||||||||.|||.|||..|
pieniysatkigkescferivarfgrkvtyvvigdgkdeetaakkln

Phosphatase EYA3.AA Group.HAD.PD 304-531 20 6.4e-34 105.5 In-house 2-190 (190) Show / Hide
Range on Protein: 304-531
Range on HMM: 2-190/190
Sequence Identity: 20% (46 aa)

RVFLWDLDETIIifhslLTGSYAQKYGKDPTVVIGSGLTMeemifEVADTHLFFNDLEECDQVHVEDVAsddngqdlsnysFSTDGFSGSG---------
.....|||....     |.||.....|..  .    .||.     . ....|.... .......||.|.            . .|.|  ...|..     
dtlvlDldgvlw-----lhgspepleglrskgkvlifltn-----natksrlyllkrlallgflveeve------------phldeflervgelyelvvf

GSGSHGSSVGVQGGVDWMrKLAFRYRKVREIYDKHKSnVGGLLSPQRKealqrlraeievlTDSWLGTALKSLLLIQSRKNCVNVLItttqlvpALAKVL
| |.||.. ..||.|||.|. .  .|. .|.|| .. .             ....|. .|...  |. .......... ...|..|      |..|..|.
tagtreyadpvvgavdvg-deafsyrklrdacvylkg-pgalllatnr-------------dlgalvrdlekvviidnkpsvfafec-------npenal

LYGLGeifpIENIYSATKIGKESCFERIVSRFGKKVT
..|.....|.|..||||.|.                 
migdf----iddildaellglipdlenidvrfgkdvg

Phosphatase EYA3.AA Hydrolase 303-549 11 1.4e-12 44.54 Pfam 1-167 (167) Show / Hide
Range on Protein: 303-549
Range on HMM: 1-167/167
Sequence Identity: 11% (30 aa)

ERVFLWDLDETIIIF----HSLLTGSYAQKYGKDPTVVIGSGLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGS
 .....|.| |.. .    |   . . |..||.                ||... ..     .  |... .  | |...                     
IKAVVFDKDGTLTDGSEHPHAQAWVEAAREYGY--------------WPFEEVEYIWGRGI-G--DRIIDWWRATDEHI---------------------

HGSSVGVQGGVDWMRKLAFRYRKVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALKSLLLIQSRKNCVNVLITTTQLVPALAKVLLYGL
                                               .  . ..... | ..  | . |  .... ..  ..|| .   .| |.. ..|.
-----------------------------------------------D-EYLGVIAD-DQPYPGAREALQALKRM-GIKVAMITNDNR-NAQAVLEHLGI

GEIFPIENIYSATKI---GKESCFERIVSRFGKKVT---YVVIGDGRDEEIAAKQHN
. .| .  ... ..|    .  ..|... |.|.|.    ....|||    ....|..
A-YFDHIIDSDDVGIVGKPHPEMYEKACQRLGVKPHECGCMMVGDGINDDPMLAQAG

Sequence
Name Sequence Type Origin Length Description Download
EYA3.AA Protein None 573 None Fasta, JSON
EYA3.NA RNA None 1719 None Fasta, JSON
EYA3.AA.PD_303-549 Protein Phosphatase Domain None 247 None Fasta, JSON